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Ozonation technology has problems such as low gas-liquid mass transfer efficiency and low ozone utilization. The improvement of ozone aeration conditions is an effective approach to enhance ozone mass transfer. In this regard, an experimental study of ozone aeration with ceramic membranes was carried out to characterize the microporosity and morphological structure of ceramic membranes, and to investigate effects of different operating conditions on ozone mass transfer. The results showed that the ozone mass transfer coefficient firstly increased and then decreased with the increase of inlet gas flow rate and gas-phase ozone concentration. The optimal conditions were 0.4 L/min and 28 mg/L. The hydrophobic modification of ceramic membrane surface could enhance the ozone mass transfer efficiency. Ozone solubility and mass transfer efficiency increased with the decrease of membrane pore size. With the increase of aeration pressure from 0.1 MPa to 0.5 MPa, the ozone mass transfer efficiency firstly increased and then decreased, and the optimal aeration pressure was about 0.3 MPa. The mechanism of ceramic membrane pressurized aeration to strengthen the ozone mass transfer was analyzed based on Young-Laplace equation.

The accuracy of blood glucose measurement in clinical laboratories is vital for diabetes diagnosis. Trueness Verification Plan was carried out and analyzed for evaluating the standardization of serum glucose among clinical laboratories.

In response to the issue of small particle size and difficult removal of suspended particles in the mine water of Baorixile open-pit coal mine, this study probed into the optimal parameters of the coagulation and precipitation process through single-factor and orthogonal experiments, and explored the mechanism behind the coagulation of fine particles in mine water.The optimal process parameters for coagulation and precipitation include: 50 mg/L of polyaluminum chloride (PAC), 5.0 mg/L of non-ionic polyacrylamide (NPAM) under 1 minute of rapid stirring (300 r/min), 8 minutes of slow stirring (50 r/min), and 5 minutes of settling.Under these optimum process conditions, the concentration of suspended solids (SS) is 5.0 mg/L with a removal efficiency of 99.1 %.Compared to the sole addition of PAC, the removal efficiency of fine particles below 10 μm increased by 25.9 %.Additionally, theζpotential of the mine water decreased from -40.9 mV to -16.3 mV, indicating that the coagulation mechanism of fine particles is mainly attributed to the adsorption and charge neutralization of PAC and the bridging effect of PAM.

Esophageal cancer (EC) is one of the most fatal cancers worldwide. According to GLOBOCAN 2020, it was estimated that there were 600, 000 new EC cases and 540 000 EC deaths, while nearly half of all newly diagnosed cases of EC and associated deaths worldwide occurred in China. The annual incidence and mortality of EC have been reduced in the last 20 years in China. However, the early symptoms and signs of EC are not easily distinguished and the disease tends to be within the middle and late stage of pathogenesis when identified, leading to its low 5-year survival rate. Therefore, it could help effectively reduce the burden of EC by clarifying its etiology and risk factors, as well as taking preventive and early diagnosis measures. This article reviews the epidemiology, etiology, screening and early diagnosis of EC in China, to provide systematic references for EC prevention and control.

To investigate the genetic basis of processing quality- and yield-related traits in bread wheat (Triticum aestivum L., AABBDD), a systematic analysis of wheat processing quality- and yield-related traits based on genome-wide association studies (GWASs) of 285 regional test lines of wheat from Hebei province, China, was conducted. A total of 87 quantitative trait loci (QTL), including twenty-one for water absorption (WA), four for wet gluten content, eight for grain protein content, seventeen for dough stability time (DST), thirteen for extension area (EA), twelve for maximum resistance (MR), five for thousand-grain weight (TGW), one for grain length, and six for grain width were identified. These QTL harbored 188 significant single-nucleotide polymorphisms (SNPs). Twenty-five SNPs were simultaneously associated with multiple traits. Notably, the SNP AX-111015470 on chromosome 1A was associated with DST, EA, and MR. SNPs AX-111917292 and AX-109124553 on chromosome 5D were associated with wheat WA and TGW. Most processing quality-related QTL and seven grain yield-related QTL identified in this study were newly discovered. Among the surveyed accessions, 18 rare superior alleles were identified. This study identified significant QTL associated with quality-related and yield-related traits in wheat, and some of them showed pleiotropic effects. This study will facilitate molecular designs that seek to achieve synergistic improvements of wheat quality and yield. [ABSTRACT FROM AUTHOR]

Aims: Comorbid anxiodepressive‐like symptoms (CADS) in chronic pain are closely related to the overactivation of the lateral habenula (LHb). Hyperpolarization‐activated cyclic nucleotide‐gated (HCN) channels have been implicated to play a key role in regulating neuronal excitability. However, the role of HCN channels in the LHb during CADS has not yet been characterized. This study aimed to investigate the effect of HCN channels in the LHb on CADS during chronic pain. Methods: After chronic neuropathic pain induction by spared nerve injury (SNI), mice underwent a sucrose preference test, forced swimming test, tail suspension test, open‐field test, and elevated plus maze test to evaluate their anxiodepressive‐like behaviors. Electrophysiological recordings, immunohistochemistry, Western blotting, pharmacological experiments, and virus knockdown strategies were used to investigate the underlying mechanisms. Results: Evident anxiodepressive‐like behaviors were observed 6w after the SNI surgery, accompanied by increased neuronal excitability, enhanced HCN channel function, and increased expression of HCN2 isoforms in the LHb. Either pharmacological inhibition or virus knockdown of HCN2 channels significantly reduced LHb neuronal excitability and ameliorated both pain and depressive‐like behaviors. Conclusion: Our results indicated that the LHb neurons were hyperactive under CADS in chronic pain, and this hyperactivation possibly resulted from the enhanced function of HCN channels and up‐regulation of HCN2 isoforms. [ABSTRACT FROM AUTHOR]