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7. Abstract 66: Diffusion Imaging Demonstrates White Matter Alterations In Children With Moyamoya In Watershed Tracts

Author

Ahtam, Banu, primary, Feldman, Henry A, additional, Solti, Marina, additional, Doo, Justin, additional, O'Donnell, Lauren, additional, Zhang, Fan, additional, Vyas, Rutvi, additional, Rathi, Yogesh, additional, Orbach, Darren, additional, See, Alfred P, additional, Smith, Edward R, additional, Grant, P E, additional, and Lehman, Laura L, additional

Published
2023
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10. Increased Breastfeeding Proportion Is Associated with Improved Gross Motor Skills at 3–5 Years of Age: A Pilot Study

Author

D’Souza, Erica E., primary, Vyas, Rutvi, additional, Sisitsky, Michaela, additional, Feldman, Henry A., additional, Gagoski, Borjan, additional, Litt, Jonathan, additional, Larsen, Ryan J., additional, Kuchan, Matthew J., additional, Lasekan, John B., additional, Sutton, Brad P., additional, Grant, Patricia Ellen, additional, Ou, Yangming, additional, and Morton, Sarah U., additional

Published
2022
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11. Proceedings of the 13th International Newborn Brain Conference: Other forms of brain monitoring, such as NIRS, fMRI, biochemical

Author

Balashova, Ekaterina, Beaulieu, Olivia, Benhmida, Imen, Birca, Ala, Boylan, Geraldine, Carkeek, Katherine, Chowdhury, Rasheda, Cilio, Maria Roberta, Consoli, Anna, Cote Corriveau, Gabriel, Cuddyer, Deborah, Degtyarev, Dmitriy, Dehaes, Mathieu, Dempsey, Eugene, Dereymaeker, Anneleen, Desnous, Beatrice, El-Dib, Mohamed, Elsayed, Elhaytham, Feldman, Henry A, Finn, Daragh, Franceschini, Maria Angela, Freeman, Shoshana, Gagnon, Marie-Michele, Gagnon, Melanie, Garvey, Aisling, Ghosh, Anirban, Golubtsova, Yulia, Grant, P Ellen, Hay, Susanne C, Hermans, Tim, Herzberg, Emily, Hsiao, Chuan-Heng, Iennaco, Maria, Inder, Terrie, Ionov, Oleg, Kaya, Kutlu, Keister, Faith, Kemigisha, Miriah, Kirtbaya, Anna, Lee, Sarah, Leijser, Lara, Liao, Steve, Lin, Pei-Yi, Lippman, Rachel, Livingstone, Vicki, Luu, Thuy Mai, Magombe, Joshua, Mahdi, Zamzam, Marandyuk, Bohdana, Martin, Alyssa, Mathieson, Sean, Mbabazi, Edith, Mohammad, Khorshid, Moore, Michael, Mulondo, Ronald, Munster, Chelsea, Murray, Deirdre, Nalule, Esther, Natukwatsa, Davis, Naulaers, Gunnar, Noroozi, Mona, Nsubuga, Brian, O'Toole, John, Pavel, Andreea, Peterson, Mallory, Pinchefsky, Elana, Playter, Katharine, Queally, Jennifer, Rajaram, Ajay, Ryndin, Andrey, Schiff, Steven, Seruwu, Marvin, Sharafutdinova, Diiana, Sheldon, Yvonne, Simard, Marie-Noelle, Sims, Jessica, Steele, Tina, Stritzke, Amelie, Sunwoo, John, Sutin, Jason, Tatz, Julia, Vadset, Taylor, Vesoulis, Zachary, Vyas, Rutvi, Wabukoma, Moses, Walsh, Brian, Wandukwa, Joshua, Warf, Benjamin, Whitehead, Halana, Woglom, Michael, Yen, Fan-Yu, Zampolli, Lucca, Zavriyev, Alexander I, Zein, Hussein, Zimmermann, Bernhard, and Zubkov, Victor

Subjects
Infant, Newborn, Brain, Humans, Head, Magnetic Resonance Imaging
Abstract

ispartof: J Neonatal Perinatal Med vol:15 issue:2 pages:453-465 ispartof: location:Netherlands status: published

Published
2022

13. Improving Infant Hydrocephalus Outcomes in Uganda: A Longitudinal Prospective Study Protocol for Predicting Developmental Outcomes and Identifying Patients at Risk for Early Treatment Failure after ETV/CPC

Author

Vadset, Taylor A., primary, Rajaram, Ajay, additional, Hsiao, Chuan-Heng, additional, Kemigisha Katungi, Miriah, additional, Magombe, Joshua, additional, Seruwu, Marvin, additional, Kaaya Nsubuga, Brian, additional, Vyas, Rutvi, additional, Tatz, Julia, additional, Playter, Katharine, additional, Nalule, Esther, additional, Natukwatsa, Davis, additional, Wabukoma, Moses, additional, Neri Perez, Luis E., additional, Mulondo, Ronald, additional, Queally, Jennifer T., additional, Fenster, Aaron, additional, Kulkarni, Abhaya V., additional, Schiff, Steven J., additional, Grant, Patricia Ellen, additional, Mbabazi Kabachelor, Edith, additional, Warf, Benjamin C., additional, Sutin, Jason D. B., additional, and Lin, Pei-Yi, additional

Published
2022
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14. Assessment of Maternal Macular Pigment Optical Density (MPOD) as a Potential Marker for Dietary Carotenoid Intake during Lactation in Humans

Author

Al-Hassan, Ateka, primary, Vyas, Rutvi, additional, Zhang, Yue, additional, Sisitsky, Michaela, additional, Gagoski, Borjan, additional, Litt, Jonathan S., additional, Larsen, Ryan J., additional, Kuchan, Matthew J., additional, Lasekan, John B., additional, Sutton, Brad P., additional, Grant, Patricia Ellen, additional, Ou, Yangming, additional, and Morton, Sarah U., additional

Published
2021
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15. Increased Breastfeeding Proportion Is Associated with Improved Gross Motor Skills at 3–5 Years of Age: A Pilot Study.

Author

D'Souza, Erica E., Vyas, Rutvi, Sisitsky, Michaela, Feldman, Henry A., Gagoski, Borjan, Litt, Jonathan, Larsen, Ryan J., Kuchan, Matthew J., Lasekan, John B., Sutton, Brad P., Grant, Patricia Ellen, Ou, Yangming, and Morton, Sarah U.

Abstract

Breastmilk provides key nutrients and bio-active factors that contribute to infant neurodevelopment. Optimizing maternal nutrition could provide further benefit to psychomotor outcomes. Our observational cohort pilot study aims to determine if breastfeeding extent and breastmilk nutrients correlate with psychomotor outcomes at school age. The breastfeeding proportion at 3 months of age and neurodevelopmental outcomes at 3–5 years of age were recorded for 33 typically developing newborns born after uncomplicated pregnancies. The association between categorical breastfeeding proportion and neurodevelopmental outcome scores was determined for the cohort using a Spearman correlation with and without the inclusion of parental factors. Vitamin E and carotenoid levels were determined in breastmilk samples from 14 of the mothers. After the inclusion of parental education and income as covariates, motor skill scores positively correlated with breastmilk contents of α-tocopherol (Spearman coefficient 0.88, p-value = 0.02), translutein (0.98, p-value = 0.0007), total lutein (0.92, p-value = 0.01), and zeaxanthin (0.93, p-value = 0.0068). Problem solving skills negatively correlated with the levels of the RSR enantiomer of α-tocopherol (−0.86, p-value = 0.03). Overall, higher exposure to breastfeeding was associated with improved gross motor and problem-solving skills at 3–5 years of age. The potential of α-tocopherol, lutein, and zeaxanthin intake to provide neurodevelopmental benefit is worthy of further investigation. [ABSTRACT FROM AUTHOR]

Published
2022
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19. Optimizing Unanesthetized Cerebral Oxygen Consumption Measures: Comparison of NIRS and MRI Approaches in Neonates with Congenital Heart Disease

Author

Harvard-MIT Program in Health Sciences and Technology, Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science, Stout, Jeffrey Neil, Adalsteinsson, Elfar, Ferradal, Silvina, Gagoski, Borjan, Vyas, Rutvi, Ha, Christopher, Bolar, Divya S., Cheng, Henry H., Newburger, Jane, Franceschini, Maria Angela, Grant, Ellen, Harvard-MIT Program in Health Sciences and Technology, Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science, Stout, Jeffrey Neil, Adalsteinsson, Elfar, Ferradal, Silvina, Gagoski, Borjan, Vyas, Rutvi, Ha, Christopher, Bolar, Divya S., Cheng, Henry H., Newburger, Jane, Franceschini, Maria Angela, and Grant, Ellen

Abstract

Cerebral perfusion in neonates with congenital heart disease is a clinical concern. Combined measures of MRI and NIRS can provide complementary information to improve monitoring. We compare multimodal measures of cerebral hemodynamics in this group.

Published
2017

20. Non-invasive Assessment of Cerebral Blood Flow and Oxygen Metabolism in Neonates during Hypothermic Cardiopulmonary Bypass: Feasibility and Clinical Implications

Author

Ferradal, Silvina L., primary, Yuki, Koichi, additional, Vyas, Rutvi, additional, Ha, Christopher G., additional, Yi, Francesca, additional, Stopp, Christian, additional, Wypij, David, additional, Cheng, Henry H., additional, Newburger, Jane W., additional, Kaza, Aditya K., additional, Franceschini, Maria A., additional, Kussman, Barry D., additional, and Grant, P. Ellen, additional

Published
2017
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22. Cerebral Hemodynamics in Infants with Sickle Cell Disease Indicate Presence of Early Hemodynamic Stress

Author

Lin, Pei-Yi, Vyas, Rutvi, Woglom, Michael, Stout, Jeffrey N., Esrick, Erica B., Heeney, Matthew M., Archer, Natasha, Grant, P. Ellen, and Sutin, Jason

Abstract

Introduction:One of the most severe complications of sickle cell disease (SCD) is ischemic brain injury, caused by a combination of decreased oxygen transport delivery related to intravascular vaso-occlusion of sickle erythrocytes and/or cerebral vasculopathy. While newborn screening programs diagnose SCD shortly after birth, routine risk assessment for stroke typically starts with transcranial ultrasound doppler (TCD) at two years of age or later. Yet, little is known about how SCD affects cerebral hemodynamics during infancy, a crucial period for brain development. To address this gap, we used advanced quantitative near-infrared spectroscopy (qNIRS) to non-invasively monitor cerebral tissue hemoglobin concentration (HbT), oxygenation (SO 2), oxygen extraction fraction (cFTOE), blood flow (CBF), and oxygen metabolism (CMRO 2) in infants with SCD. Abnormal CBF and cFTOE indicate hemodynamic stress that may increase stroke risk. Our study aims to investigate the effects of SCD on cerebral oxygen transport in infancy and its associations with age and blood hemoglobin concentration (HgB).

Published
2023
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23. Perioperative cerebral hemodynamics and oxygen metabolism in neonates with single-ventricle physiology

Author

Dehaes, Mathieu, primary, Cheng, Henry H., additional, Buckley, Erin M., additional, Lin, Pei-Yi, additional, Ferradal, Silvina, additional, Williams, Kathryn, additional, Vyas, Rutvi, additional, Hagan, Katherine, additional, Wigmore, Daniel, additional, McDavitt, Erica, additional, Soul, Janet S., additional, Franceschini, Maria Angela, additional, Newburger, Jane W., additional, and Ellen Grant, P., additional

Published
2015
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24. Assessment of Maternal Macular Pigment Optical Density (MPOD) as a Potential Marker for Dietary Carotenoid Intake during Lactation in Humans.

Author

Al-Hassan, Ateka, Vyas, Rutvi, Zhang, Yue, Sisitsky, Michaela, Gagoski, Borjan, Litt, Jonathan S., Larsen, Ryan J., Kuchan, Matthew J., Lasekan, John B., Sutton, Brad P., Grant, Patricia Ellen, Ou, Yangming, and Morton, Sarah U.

Abstract

Pregnancy and lactation can change the maternal nutrient reserve. Non-invasive, quantitative markers of maternal nutrient intake could enable personalized dietary recommendations that improve health outcomes in mothers and infants. Macular pigment optical density (MPOD) is a candidate marker, as MPOD values generally reflect carotenoid intake. We evaluated the association of MPOD with dietary and breastmilk carotenoids in postpartum women. MPOD measurements and dietary intake of five carotenoids were obtained from 80 mothers in the first three months postpartum. Breastmilk samples from a subset of mothers were analyzed to determine their nutrient composition. The association between MPOD and dietary or breastmilk carotenoids was quantitatively assessed to better understand the availability and mobilization of carotenoids. Our results showed that dietary α-carotene was positively correlated with MPOD. Of the breastmilk carotenoids, 13-cis-lutein and trans-lutein were correlated with MPOD when controlled for the total lutein in breastmilk. Other carotenoids in breastmilk were not associated with MPOD. Maternal MPOD is positively correlated with dietary intake of α-carotene in the early postpartum period, as well as with the breastmilk content of lutein. MPOD may serve as a potential marker for the intake of carotenoids, especially α-carotene, in mothers in the early postpartum period. [ABSTRACT FROM AUTHOR]

Published
2022
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