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1. Study protocol for a pragmatic cluster randomized controlled trial to improve dietary diversity and physical fitness among older people who live at home (the “ALAPAGE study”)

Author

Bocquier, Aurélie, Jacquemot, Anne-Fleur, Dubois, Christophe, Tréhard, Hélène, Cogordan, Chloé, Maradan, Gwenaëlle, Cortaredona, Sébastien, Fressard, Lisa, Davin-Casalena, Bérengère, Vinet, Agnès, Verger, Pierre, Darmon, Nicole, Arquier, Valérie, Briclot, Guillaume, Chamla, Rachel, Cousson-Gélie, Florence, Danthony, Sarah, Delrieu, Karin, Dessirier, Julie, Féart, Catherine, Fusinati, Christine, Gazan, Rozenn, Gibert, Mélissa, Lamiraud, Valérie, Maillot, Matthieu, Nadal, Dolorès, Trotta, Christelle, Verger, Eric O., and Viriot, Valérie

Published
2022
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3. Additional file 1 of Study protocol for a pragmatic cluster randomized controlled trial to improve dietary diversity and physical fitness among older people who live at home (the 'ALAPAGE study')

Author

Bocquier, Aurélie, Jacquemot, Anne-Fleur, Dubois, Christophe, Tréhard, Hélène, Cogordan, Chloé, Maradan, Gwenaëlle, Cortaredona, Sébastien, Fressard, Lisa, Davin-Casalena, Bérengère, Vinet, Agnès, Verger, Pierre, Darmon, Nicole, Arquier, Valérie, Briclot, Guillaume, Chamla, Rachel, Cousson-Gélie, Florence, Danthony, Sarah, Delrieu, Karin, Dessirier, Julie, Féart, Catherine, Fusinati, Christine, Gazan, Rozenn, Gibert, Mélissa, Lamiraud, Valérie, Maillot, Matthieu, Nadal, Dolorès, Trotta, Christelle, Verger, Eric O., and Viriot, Valérie

Abstract

Additional file 1. SPIRIT 2013 Checklist.

Published
2022
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4. Additional file 4 of Study protocol for a pragmatic cluster randomized controlled trial to improve dietary diversity and physical fitness among older people who live at home (the 'ALAPAGE study')

Author

Bocquier, Aurélie, Jacquemot, Anne-Fleur, Dubois, Christophe, Tréhard, Hélène, Cogordan, Chloé, Maradan, Gwenaëlle, Cortaredona, Sébastien, Fressard, Lisa, Davin-Casalena, Bérengère, Vinet, Agnès, Verger, Pierre, Darmon, Nicole, Arquier, Valérie, Briclot, Guillaume, Chamla, Rachel, Cousson-Gélie, Florence, Danthony, Sarah, Delrieu, Karin, Dessirier, Julie, Féart, Catherine, Fusinati, Christine, Gazan, Rozenn, Gibert, Mélissa, Lamiraud, Valérie, Maillot, Matthieu, Nadal, Dolorès, Trotta, Christelle, Verger, Eric O., and Viriot, Valérie

Abstract

Additional file 4. Food Frequency Questionnaire (FFQ).

Published
2022
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5. Additional file 5 of Study protocol for a pragmatic cluster randomized controlled trial to improve dietary diversity and physical fitness among older people who live at home (the 'ALAPAGE study')

Author

Bocquier, Aurélie, Jacquemot, Anne-Fleur, Dubois, Christophe, Tréhard, Hélène, Cogordan, Chloé, Maradan, Gwenaëlle, Cortaredona, Sébastien, Fressard, Lisa, Davin-Casalena, Bérengère, Vinet, Agnès, Verger, Pierre, Darmon, Nicole, Arquier, Valérie, Briclot, Guillaume, Chamla, Rachel, Cousson-Gélie, Florence, Danthony, Sarah, Delrieu, Karin, Dessirier, Julie, Féart, Catherine, Fusinati, Christine, Gazan, Rozenn, Gibert, Mélissa, Lamiraud, Valérie, Maillot, Matthieu, Nadal, Dolorès, Trotta, Christelle, Verger, Eric O., and Viriot, Valérie

Abstract

Additional file 5. Self-administered questionnaires’ sections related to process evaluation.

Published
2022
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6. Additional file 2 of Study protocol for a pragmatic cluster randomized controlled trial to improve dietary diversity and physical fitness among older people who live at home (the 'ALAPAGE study')

Author

Bocquier, Aurélie, Jacquemot, Anne-Fleur, Dubois, Christophe, Tréhard, Hélène, Cogordan, Chloé, Maradan, Gwenaëlle, Cortaredona, Sébastien, Fressard, Lisa, Davin-Casalena, Bérengère, Vinet, Agnès, Verger, Pierre, Darmon, Nicole, Arquier, Valérie, Briclot, Guillaume, Chamla, Rachel, Cousson-Gélie, Florence, Danthony, Sarah, Delrieu, Karin, Dessirier, Julie, Féart, Catherine, Fusinati, Christine, Gazan, Rozenn, Gibert, Mélissa, Lamiraud, Valérie, Maillot, Matthieu, Nadal, Dolorès, Trotta, Christelle, Verger, Eric O., and Viriot, Valérie

Abstract

Additional file 2. Control group measurement visits’ content.

Published
2022
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7. Additional file 7 of Study protocol for a pragmatic cluster randomized controlled trial to improve dietary diversity and physical fitness among older people who live at home (the 'ALAPAGE study')

Author

Bocquier, Aurélie, Jacquemot, Anne-Fleur, Dubois, Christophe, Tréhard, Hélène, Cogordan, Chloé, Maradan, Gwenaëlle, Cortaredona, Sébastien, Fressard, Lisa, Davin-Casalena, Bérengère, Vinet, Agnès, Verger, Pierre, Darmon, Nicole, Arquier, Valérie, Briclot, Guillaume, Chamla, Rachel, Cousson-Gélie, Florence, Danthony, Sarah, Delrieu, Karin, Dessirier, Julie, Féart, Catherine, Fusinati, Christine, Gazan, Rozenn, Gibert, Mélissa, Lamiraud, Valérie, Maillot, Matthieu, Nadal, Dolorès, Trotta, Christelle, Verger, Eric O., and Viriot, Valérie

Abstract

Additional file 7. Sample size calculation.

Published
2022
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8. Additional file 6 of Study protocol for a pragmatic cluster randomized controlled trial to improve dietary diversity and physical fitness among older people who live at home (the 'ALAPAGE study')

Author

Bocquier, Aurélie, Jacquemot, Anne-Fleur, Dubois, Christophe, Tréhard, Hélène, Cogordan, Chloé, Maradan, Gwenaëlle, Cortaredona, Sébastien, Fressard, Lisa, Davin-Casalena, Bérengère, Vinet, Agnès, Verger, Pierre, Darmon, Nicole, Arquier, Valérie, Briclot, Guillaume, Chamla, Rachel, Cousson-Gélie, Florence, Danthony, Sarah, Delrieu, Karin, Dessirier, Julie, Féart, Catherine, Fusinati, Christine, Gazan, Rozenn, Gibert, Mélissa, Lamiraud, Valérie, Maillot, Matthieu, Nadal, Dolorès, Trotta, Christelle, Verger, Eric O., and Viriot, Valérie

Abstract

Additional file 6. Self-administered questionnaires’ section related to participant’s characteristics.

Published
2022
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9. Additional file 3 of Study protocol for a pragmatic cluster randomized controlled trial to improve dietary diversity and physical fitness among older people who live at home (the 'ALAPAGE study')

Author

Bocquier, Aurélie, Jacquemot, Anne-Fleur, Dubois, Christophe, Tréhard, Hélène, Cogordan, Chloé, Maradan, Gwenaëlle, Cortaredona, Sébastien, Fressard, Lisa, Davin-Casalena, Bérengère, Vinet, Agnès, Verger, Pierre, Darmon, Nicole, Arquier, Valérie, Briclot, Guillaume, Chamla, Rachel, Cousson-Gélie, Florence, Danthony, Sarah, Delrieu, Karin, Dessirier, Julie, Féart, Catherine, Fusinati, Christine, Gazan, Rozenn, Gibert, Mélissa, Lamiraud, Valérie, Maillot, Matthieu, Nadal, Dolorès, Trotta, Christelle, Verger, Eric O., and Viriot, Valérie

Abstract

Additional file 3. Diversity ALAPAGE Score: calculation method.

Published
2022
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17. Erratum. Increased Prevalence of Type 2 Diabetes–Related Complications in Combined Type 2 Diabetes and Sickle Cell Trait. Diabetes Care 2018;41:2595—2602

Author

Skinner, Sarah C., primary, Diaw, Mor, additional, Pialoux, Vincent, additional, Mbaye, Maïmouna Ndour, additional, Mury, Pauline, additional, Lopez, Philomène, additional, Bousquet, Delphine, additional, Gueye, Fatou, additional, Diedhiou, Demba, additional, Joly, Philippe, additional, Renoux, Céline, additional, Sow, Djiby, additional, Diop, Saliou, additional, Ranque, Brigitte, additional, Vinet, Agnès, additional, Samb, Abdoulaye, additional, Guillot, Nicolas, additional, and Connes, Philippe, additional

Published
2019
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18. Increased Prevalence of Type 2 Diabetes–Related Complications in Combined Type 2 Diabetes and Sickle Cell Trait

Author

Skinner, Sarah C., primary, Diaw, Mor, additional, Pialoux, Vincent, additional, Mbaye, Maïmouna Ndour, additional, Mury, Pauline, additional, Lopez, Philomène, additional, Bousquet, Delphine, additional, Gueye, Fatou, additional, Diedhiou, Demba, additional, Joly, Philippe, additional, Renoux, Céline, additional, Sow, Djiby, additional, Diop, Saliou, additional, Ranque, Brigitte, additional, Vinet, Agnès, additional, Samb, Abdoulaye, additional, Guillot, Nicolas, additional, and Connes, Philippe, additional

Published
2018
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19. Long-term cost reduction of routine medications following a residential programme combining physical activity and nutrition in the treatment of type 2 diabetes: a prospective cohort study

Author

Lanhers, Charlotte, primary, Walther, Guillaume, additional, Chapier, Robert, additional, Lesourd, Bruno, additional, Naughton, Geraldine, additional, Pereira, Bruno, additional, Duclos, Martine, additional, Vinet, Agnès, additional, Obert, Philippe, additional, Courteix, Daniel, additional, and Dutheil, Frédéric, additional

Published
2017
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20. Metabolic Syndrome Individuals With and Without Type 2 Diabetes Mellitus Present Generalized Vascular Dysfunction

Author

Walther, Guillaume, Obert, Philippe, Dutheil, Frederic, Chapier, Robert, Lesourd, Bruno, Naughton, Geraldine, Courteix, Daniel, Vinet, Agnès, EA4278 Laboratoire de Pharm-Ecologie Cardiovasculaire (LaPEC), Avignon Université (AU), Laboratoire de Psychologie Sociale et Cognitive (LAPSCO), and Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)

Subjects
[SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2015

21. Generalized vascular dysfunction in metabolic syndrome with and without type 2 diabetes: a cross sectional study

Author

Walther, Guillaume, Obert, Philippe, Dutheil, Frédéric, Chapier, Robert, Lesourd, B., Naughton, Geraldine, Courteix, D., Vinet, Agnès, Déposants HAL-Avignon, bibliothèque Universitaire, EA4278 Laboratoire de Pharm-Ecologie Cardiovasculaire (LaPEC), Avignon Université (AU), Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Ferrand (UFR STAPS - UBP), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP), Australian National University (ANU), Laboratoire de Biologie des Activités Physiques et Sportives (BAPS), and Université Blaise Pascal - Clermont-Ferrand 2 (UBP)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2015

22. Correction: Multilevel Approach of a 1-Year Program of Dietary and Exercise Interventions on Bone Mineral Content and Density in Metabolic Syndrome - the RESOLVE Randomized Controlled Trial

Author

Courteix, Daniel, primary, Valente-dos-Santos, João, additional, Ferry, Béatrice, additional, Lac, Gérard, additional, Lesourd, Bruno, additional, Chapier, Robert, additional, Naughton, Geraldine, additional, Marceau, Geoffroy, additional, Coelho-e-Silva, Manuel João, additional, Vinet, Agnès, additional, Walther, Guillaume, additional, Obert, Philippe, additional, and Dutheil, Frédéric, additional

Published
2015
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23. Multilevel Approach of a 1-Year Program of Dietary and Exercise Interventions on Bone Mineral Content and Density in Metabolic Syndrome – the RESOLVE Randomized Controlled Trial

Author

Courteix, Daniel, primary, Valente-dos-Santos, João, additional, Ferry, Béatrice, additional, Lac, Gérard, additional, Lesourd, Bruno, additional, Chapier, Robert, additional, Naughton, Geraldine, additional, Marceau, Geoffroy, additional, João Coelho-e-Silva, Manuel, additional, Vinet, Agnès, additional, Walther, Guillaume, additional, Obert, Philippe, additional, and Dutheil, Frédéric, additional

Published
2015
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25. Effects of a Lifestyle Program on Vascular Reactivity in Macro- and Microcirculation in Severely Obese Adolescents

Author

Universidad de Alicante. Departamento de Biotecnología, Montero, David, Walther, Guillaume, Pérez Martín, Antonia, Mercier, Charles S., Gayrard, Sandrine, Vicente Salar, Nestor, Sempere Ortells, José Miguel, Martínez-Peinado, Pascual, Roche, Enrique, Vinet, Agnès, Universidad de Alicante. Departamento de Biotecnología, Montero, David, Walther, Guillaume, Pérez Martín, Antonia, Mercier, Charles S., Gayrard, Sandrine, Vicente Salar, Nestor, Sempere Ortells, José Miguel, Martínez-Peinado, Pascual, Roche, Enrique, and Vinet, Agnès

Abstract

Context and Objective: This study aimed to comprehensively assess the macro- and microcirculation of severely obese adolescents (SOA) and normal-weight counterparts and to determine the longitudinal effects of weight loss on vascular function in SOA. Design, Setting, Participants, and Outcome Measures: Seventeen SOA (body mass index z-score = 4.22 ± 0.73) and 19 puberty-matched normal-weight counterparts (body mass index z-score = −0.02 ± 1.04) were included. The SOA participated in a 4 month weight loss program. Brachial artery flow-mediated dilation and response to sublingual nitrate (nitrate-mediated dilation [NMD]) were assessed by high-resolution ultrasound. Microvascular reactivity was evaluated by laser Doppler flowmetry in response to NMD, iontophoresis of acetylcholine and sodium nitroprusside, and local hyperthermia. Plasma insulin, leptin, resistin, C-reactive protein, myeloperoxidase, and tissue plasminogen activator were measured. Results: At baseline, SOA had similar flow-mediated dilation and impaired NMD in the brachial artery compared to normal-weight adolescents. Similarly, peak responses to acetylcholine and sodium nitroprusside iontophoresis and to local hyperthermia were unaltered, whereas cutaneous blood flow after NMD was lower in the forearm microcirculation of SOA. All plasma measurements were significantly higher in SOA. After the 4-month program, SOA presented a weight reduction of 7.4 ± 3.1%, but neither brachial artery nor microvascular reactivity variables were improved. Significant decreases were detected in plasma leptin, myeloperoxidase, and tissue plasminogen activator. Conclusions: Macro- and microvascular endothelial function are preserved in adolescents with severe obesity. Conversely, weight loss does not improve their impaired smooth muscle response to exogenous organic nitrate in both vascular beds, despite reducing plasma markers adversely related to vascular homeostasis.

Published
2014

27. Atherogenic subfractions of lipoproteins in the treatment of metabolic syndrome by physical activity and diet – the RESOLVE trial

Author

Dutheil, Frédéric, primary, Walther, Guillaume, additional, Chapier, Robert, additional, Mnatzaganian, George, additional, Lesourd, Bruno, additional, Naughton, Geraldine, additional, Verney, Julien, additional, Fogli, Anne, additional, Sapin, Vincent, additional, Duclos, Martine, additional, Vinet, Agnès, additional, Obert, Philippe, additional, Courteix, Daniel, additional, and Lac, Gérard, additional

Published
2014
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31. Metabolic syndrome individuals with and without type 2 diabetes mellitus present generalized vascular dysfunction: cross-sectional study.

Author

Walther G, Obert P, Dutheil F, Chapier R, Lesourd B, Naughton G, Courteix D, and Vinet A

Subjects
Adiposity, Aged, Biomarkers blood, Blood Flow Velocity, Blood Glucose analysis, Cross-Sectional Studies, Diabetes Mellitus, Type 2 blood, Diabetes Mellitus, Type 2 diagnosis, Diabetic Angiopathies blood, Diabetic Angiopathies diagnosis, Endothelium, Vascular metabolism, Humans, Inflammation blood, Inflammation diagnosis, Inflammation physiopathology, Inflammation Mediators blood, Insulin blood, Iontophoresis, Male, Metabolic Syndrome blood, Metabolic Syndrome diagnosis, Middle Aged, Muscle, Smooth, Vascular metabolism, Nitric Oxide metabolism, Obesity, Abdominal diagnosis, Obesity, Abdominal physiopathology, Prediabetic State blood, Prediabetic State diagnosis, Predictive Value of Tests, Regional Blood Flow, Risk Factors, Risk Reduction Behavior, Vasodilator Agents administration & dosage, Diabetes Mellitus, Type 2 physiopathology, Diabetic Angiopathies physiopathology, Endothelium, Vascular physiopathology, Metabolic Syndrome physiopathology, Microcirculation drug effects, Muscle, Smooth, Vascular physiopathology, Prediabetic State physiopathology, Skin blood supply, Vasodilation drug effects
Abstract

Objectives: The first objective of this study was to demonstrate differences within endothelial-dependent and endothelial-independent vasoreactivity in macro- and microcirculation beds among patients with metabolic syndrome (MetS) with and without type 2 diabetes mellitus (T2D) compared with healthy counterparts. The second objective was to determine relationships among the function of macro- and microvascular systems and abdominal adiposity, as well as inflammatory markers in the 3 groups., Approach and Results: Cross-sectional analyses of 53 patients with MetS without T2D and 25 with T2D, as well as aged 40 years and sex-matched healthy controls included microvascular (cutaneous blood flow measured with laser Doppler flowmetry in response to iontophoresis of acetylcholine and sodium nitroprusside), and macrovascular reactivity (flow-mediated dilation and nitrate-mediated dilation) along with anthropometric measures, plasma glucose, and insulin and inflammatory markers. Compared with controls, MetS participants showed depressed endothelial function of both micro- and macrocirculation beds. T2D in patients with MetS revealed an exacerbated vascular smooth muscle dysfunction in micro- and macrocirculation compared with MetS without T2D. Indices of micro- and macrocirculation were predominantly inversely related to abdominal fat and inflammatory markers., Conclusions: MetS was associated with endothelial-dependent and endothelial-independent dysfunction, affecting both the macro- and the microvascular systems. Participants with diabetes mellitus demonstrated the most severe smooth muscle dysfunction. The presence of central abdominal fat and systemic inflammation seems implicated in the pathogenesis of vascular dysfunctions in MetS., (© 2015 American Heart Association, Inc.)

Published
2015
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