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385 results on '"Vetter, W."'

15. Odd chain fatty acids:new insights of the relationship between the gut microbiota, dietary intake, biosynthesis and glucose intolerance

Author

Jenkins, B. J. (Benjamin J.), Seyssel, K. (Kevin), Chiu, S. (Sally), Pan, P.-H. (Pin-Ho), Lin, S.-Y. (Shih-Yi), Stanley, E. (Elizabeth), Ament, Z. (Zsuzsanna), West, J. A. (James A.), Summerhill, K. (Keith), Griffin, J. L. (Julian L.), Vetter, W. (Walter), Autio, K. J. (Kaija J.), Hiltunen, K. (Kalervo), Hazebrouck, S. (Stephane), Stepankova, R. (Renata), Chen, C.-J. (Chun-Jung), Alligier, M. (Maud), Laville, M. (Martine), Moore, M. (Mary), Kraft, G. (Guillaume), Cherrington, A. (Alan), King, S. (Sarah), Krauss, R. M. (Ronald M.), de Schryver, E. (Evelyn), Van Veldhoven, P. P. (Paul P.), Ronis, M. (Martin), Koulman, A. (Albert), Jenkins, B. J. (Benjamin J.), Seyssel, K. (Kevin), Chiu, S. (Sally), Pan, P.-H. (Pin-Ho), Lin, S.-Y. (Shih-Yi), Stanley, E. (Elizabeth), Ament, Z. (Zsuzsanna), West, J. A. (James A.), Summerhill, K. (Keith), Griffin, J. L. (Julian L.), Vetter, W. (Walter), Autio, K. J. (Kaija J.), Hiltunen, K. (Kalervo), Hazebrouck, S. (Stephane), Stepankova, R. (Renata), Chen, C.-J. (Chun-Jung), Alligier, M. (Maud), Laville, M. (Martine), Moore, M. (Mary), Kraft, G. (Guillaume), Cherrington, A. (Alan), King, S. (Sarah), Krauss, R. M. (Ronald M.), de Schryver, E. (Evelyn), Van Veldhoven, P. P. (Paul P.), Ronis, M. (Martin), and Koulman, A. (Albert)

Abstract

Recent findings have shown an inverse association between circulating C15:0/C17:0 fatty acids with disease risk, therefore, their origin needs to be determined to understanding their role in these pathologies. Through combinations of both animal and human intervention studies, we comprehensively investigated all possible contributions of these fatty acids from the gut-microbiota, the diet, and novel endogenous biosynthesis. Investigations included an intestinal germ-free study and a C15:0/C17:0 diet dose response study. Endogenous production was assessed through: a stearic acid infusion, phytol supplementation, and a Hacl1−/− mouse model. Two human dietary intervention studies were used to translate the results. Finally, a study comparing baseline C15:0/C17:0 with the prognosis of glucose intolerance. We found that circulating C15:0/C17:0 levels were not influenced by the gut-microbiota. The dose response study showed C15:0 had a linear response, however C17:0 was not directly correlated. The phytol supplementation only decreased C17:0. Stearic acid infusion only increased C17:0. Hacl1−/− only decreased C17:0. The glucose intolerance study showed only C17:0 correlated with prognosis. To summarise, circulating C15:0 and C17:0 are independently derived; C15:0 correlates directly with dietary intake, while C17:0 is substantially biosynthesized, therefore, they are not homologous in the aetiology of metabolic disease. Our findings emphasize the importance of the biosynthesis of C17:0 and recognizing its link with metabolic disease.

Published
2017

16. Normal values of blood pressure self-measurement in view of the 1999 World Health Organization-International Society of Hypertension guidelines

Author

Weisser, B., Mengden, T., Düsing, R., Vetter, H., Vetter, W., Weisser, B., Mengden, T., Düsing, R., Vetter, H., and Vetter, W.

Abstract

New guidelines for the management of hypertension have been published in 1999 by the World Health Organization (WHO) and the International Society of Hypertension (ISH). The WHO/ISH Committee has adopted in principle the definition and classification of hypertension provided by the JNC VI (1997). The new classification defines a blood pressure of 120/80 mm Hg as optimal and of 130/85 mm Hg as the limit between normal and high-normal blood pressure. It is unclear which self-measured home blood pressure values correspond to these office blood pressure limits. In this study we reevaluated data from our Dübendorf study to determine self-measured blood pressure values corresponding to optimal and normal office blood pressure using the percentiles of the (office and home) blood pressure distributions of 503 individuals (age, 20 to 90 years; mean age, 46.5 years; 265 men, 238 women). Self-measured blood pressure values corresponding to office values of 130/85 mm Hg and 120/80 mm Hg were 124.1/79.9 mm Hg and 114.3/75.1 mm Hg. Thus, we propose 125/80 mm Hg as a home blood pressure corresponding to an office blood pressure of 130/85 mm Hg (WHO 1999: normal) and 115/75 mm Hg corresponding to 120/80 mm Hg (optimal). Am J Hypertens 2000;13:940-943 © 2000 American Journal of Hypertension, Ltd

Published
2017

17. Antifungal and Insecticidal properties of the Phytoconstituents of Drimys winteri (Winteraceae) growing in Chiloe Island (Chile)

Author

Gonzalez R, Gutierrez M, Muñoz O, Vetter W, and Hammann S

Subjects
biology, Winteraceae, Polygodial, Drimys winteri, biology.organism_classification, Pseudococcus viburni, chemistry.chemical_compound, chemistry, Sesamin, visual_art, Botany, visual_art.visual_art_medium, Dothiorella, Bark, Cladosporium
Abstract

Seven drimane-type sesquiterpenes: polygodial, drimenol, drimendiol, drimenin, isodrimininol, isodrimenin and proximadiol (cryptomeridiol); three lignans: sesamin, cubebin and its epimer eudesmin, and one sterol: (β-sitosterol) were isolated from Drimys winteri (Winteraceae) from Chiloe Island, Chile. Eudesmin and its phytosterols were isolated from the plant for the first time, and sesamin was found to be the major product in the plant’s bark by a significant margin. Furthermore, qualitative and quantitative differences were detected between some products. Structures were established using 1D and 2D NMR (COSY, HSQC, and HMBC) spectra, HRESIMS and comparison with published data. Some isolated compounds were tested against the phytopathogenic fungi Botritys cinerea, Dothiorella sp., Penicillium sp. and Cladosporium cladosporoides; additionally, a study was carried out to determine the contact toxic action of leaf and stem bark extracts upon phloematic insect pests from the Pseudococcus viburni (Signoret) (Hemiptera: Pseudococcidae) mealy bug complex.

Published
2015
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