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Your search keyword '"Vautherot, Jean-François"' showing total 18 results
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18 results on '"Vautherot, Jean-François"'

9. Epizootic enterocolitis of the rabbit: review of current research

Author

Licois, Dominique, Coudert, Pierre, Ceré, Nicolas, Vautherot, Jean-François, Station de Pathologie aviaire et parasitologie [Nouzilly] (PAP), Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], épizootie, health care facilities, manpower, and services, [SDV]Life Sciences [q-bio], education, entérocolite, syndrome gastrointestinal, lapin, recherche, élevage, ComputingMilieux_MISCELLANEOUS, health care economics and organizations, oryctolagus cuniculus
Abstract

Congrès publié en 3 volumes. Vol.B, chapitre : Pathology and Prophylaxis; International audience

Published
2000

10. Detection of rabbit rotavirus by polymerase chain reaction in faeces and comparison of gene 9 sequence between two isolated strains

Author

Ceré, Nicolas, Niepceron, Alisson, Vasseur, M., Lorrot, M., Vautherot, Jean-François, Licois, Dominique, Station de Pathologie aviaire et parasitologie [Nouzilly] (PAP), Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], health care facilities, manpower, and services, [SDV]Life Sciences [q-bio], education, ComputingMilieux_MISCELLANEOUS, health care economics and organizations
Abstract

Congrès publié en 3 volumes. Vol.B, chapitre : Pathology and Prophylaxis; International audience

Published
2000

18. Keratinocytes derived from chicken embryonic stem cells support Marek's disease virus infection: a highly differentiated cell model to study viral replication and morphogenesis

Author

Caroline Denesvre, Jean-François Vautherot, Laetitia Trapp-Fragnet, Katia Courvoisier, Mathilde Couteaudier, UR Infectiologie animale et Santé publique (UR IASP), Institut National de la Recherche Agronomique (INRA), French National Research Agency (ANR, 315) for MADISPREAD - ERA-NET EMIDA program, Infectiologie et Santé Publique (UMR ISP), Institut National de la Recherche Agronomique (INRA)-Université de Tours (UT), Vautherot, Jean-François, and Institut National de la Recherche Agronomique (INRA)-Université de Tours

Subjects
0301 basic medicine, Keratinocytes, morphogénèse virale, animal structures, Mardivirus, Virologie, viruses, Short Report, Marek’s disease virus, Chicken keratinocytes, Viral replication, Viral morphogenesis, poulet, Chick Embryo, Virus Replication, Virus, 03 medical and health sciences, réplication virale, Viral entry, Virology, medicine, Marek Disease, Animals, Viral shedding, Cells, Cultured, Embryonic Stem Cells, Marek's disease, kératinocyte, biology, biology.organism_classification, 3. Good health, lignée cellulaire, 030104 developmental biology, Infectious Diseases, medicine.anatomical_structure, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, virus maladie de marek, Keratinocyte, Viral load
Abstract

Background Marek’s disease is a virus disease with worldwide distribution that causes major losses to poultry production. Vaccines against Marek’s disease virus, an oncogenic alphaherpesvirus, reduce tumour formation but have no effect on virus shedding. Successful horizontal virus transmission is linked to the active viral replication in feather follicle epithelial cells of infected chickens, from which infectious viral particles are shed into the environment. The feather follicle epithelium is the sole tissue in which those infectious particles are produced and no in vitro cell-systems can support this highly efficient morphogenesis. We previously characterized embryonic stem-cell-derived keratinocytes, showing they display a marker-gene profile similar to skin keratinocytes, and therefore we tested their susceptibility to Marek’s disease virus infection. Findings We show herein that keratinocytes derived from chicken embryonic stem-cells are fully permissive to the replication of either non-pathogenic or pathogenic Marek’s disease viruses. All viruses replicated on all three keratinocyte lines and kinetics of viral production as well as viral loads were similar to those obtained on primary cells. Morphogenesis studies were conducted on infected keratinocytes and on corneocytes, showing that all types of capsids/virions were present inside the cells, but extracellular viruses were absent. Conclusions The keratinocyte lines are the first epithelial cell-line showing ectodermal specific markers supporting Marek’s disease virus replication. In this in vitro model the replication lead to the production of cell-associated viral progeny. Further work will be devoted to the study of relationship between 3D differentiation of keratinocytes and Marek’s disease virus replication.

Published
2016
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