64 results on '"Vatan MB"'
Search Results
2. Impact of direct stenting on clinical outcomes for small vessel coronary artery disease in patients undergoing primary percutaneous coronary intervention for ST-elevation myocardial infarction
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Ramazan Akdemir, Kahraman Cosansu, Çağın Mustafa Üreyen, Mehmet Bulent Vatan, Mustafa Tarık Ağaç, Harun Kilic, Cosansu, K, Ureyen, CM, Vatan, MB, Agac, MT, Kilic, H, Akdemir, R, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Vatan, Mehmet Bülent, Ağaç, Mustafa Tarık, Kılıç, Harun, and Akdemir, Ramazan
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medicine.medical_specialty ,st-elevation myocardial infarction ,medicine.medical_treatment ,lcsh:Medicine ,030204 cardiovascular system & hematology ,Lower risk ,direct stenting ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Clinical endpoint ,small vessel coronary artery ,030212 general & internal medicine ,Myocardial infarction ,cardiovascular diseases ,Original Paper ,conventional stenting ,business.industry ,lcsh:R ,Percutaneous coronary intervention ,medicine.disease ,primary percutaneous coronary intervention ,Cohort ,Cardiology ,Cardiovascular System & Cardiology ,Cardiology and Cardiovascular Medicine ,business ,TIMI ,Mace - Abstract
Introduction Direct stenting (DS) is associated with improved markers of reperfusion during primary percutaneous coronary intervention (PPCI) for ST-elevation myocardial infarction (STEMI). However, data evaluating its impact in small vessel coronary artery disease (CAD) are lacking. Aim To compare DS and conventional stenting (CS) for small vessel CAD on clinical outcomes of patients with STEMI undergoing PPCI. Material and methods A cohort of 616 STEMI patients treated with DS (202 patients) or CS (414 patients) in small vessel (≤ 2.75 mm) lesions was retrospectively analyzed. The primary endpoint was to compare the occurrence of major adverse cardiac events (MACE) between groups during 2-year follow-up. The secondary end points included in-hospital target lesion revascularization (TLR) and in-hospital death. Results The primary end-point, MACEs, occurred in 9.2% in the DS group and 12.3% in the CS group (p > 0.05). The rates of TLR, myocardial infarction (MI) and target vessel revascularization (TVR) were not significantly different between groups (p > 0.05). The stent thrombosis (ST) rate was significantly lower in the DS group (1.0% vs. 4.2%, p = 0.04) at 2 years. However, DS was not found to be an independent predictor of ST in multivariate analysis. There were no significant differences in in-hospital rates of death and TLR. The DS compared to CS resulted in greater rates of postprocedural TIMI grade 3 flow, and lower risk of edge dissection. The procedure time, radiation exposure and contrast administration were found to be significantly lower in the DS group. Conclusions In selected patients with STEMI undergoing PPCI for small vessel CAD, DS is not only safe and feasible but also reduces ST rates, contrast load, and procedural and radiation exposure time.
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- 2019
3. Is endocan a biochemical marker for asymptomatic target organ damage in hypertensive patients?
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Ağaç, Mustafa Tarık, Behlul Kahyaoglu, Muhammed Murat Necati Aksoy, Cinemre, Fatma Behice, Vatan, Mehmet Bülent, Gündüz, Yasemin, Agac, MT, Kahyaoglu, B, Aksoy, MMN, Cinemre, FB, Vatan, MB, Gunduz, Y, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Ağaç, Mustafa Tarık, Cinemre, Fatma Behice, Vatan, Mehmet Bülent, and Gündüz, Yasemin
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Male ,medicine.medical_specialty ,hypertension ,Renal function ,Blood Pressure ,Disease ,030204 cardiovascular system & hematology ,Asymptomatic ,Carotid Intima-Media Thickness ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,030212 general & internal medicine ,Endothelial dysfunction ,Original Investigation ,endocan ,business.industry ,asymptomatic target organ damage ,Middle Aged ,medicine.disease ,Target organ damage ,Pulse pressure ,Neoplasm Proteins ,Blood pressure ,Cardiovascular Diseases ,Cardiology ,Cardiovascular System & Cardiology ,Biomarker (medicine) ,Female ,Kidney Diseases ,Proteoglycans ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Biomarkers ,Glomerular Filtration Rate - Abstract
Objective Identification of the asymptomatic target organ damage (AOD) helps to stratify the overall risk of cardiovascular (CV) diseases and guides a treatment decision in hypertensive patients without a symptomatic CV or renal disease. The endothelial-cell-specific molecule 1 (endocan) is regarded as a novel marker of endothelial dysfunction. Its release is increased in hypertensive patients, especially those with symptomatic CV and renal disease. In the present study, we aimed to evaluate the endocan levels in asymptomatic hypertensive patients with or without AOD. Methods The study included 132 asymptomatic hypertensive patients, and 101 of who had at least one AOD. Results Serum endocan levels did not differ between patients with and without AOD (3.81±0.78 vs. 3.83±0.63 ng/mL, p=0.88). An analysis according to the presence of any specific AOD did not show any difference between groups. No significant correlation was found between serum endocan levels and any of the continuous variables related to AOD, such as the pulse pressure, carotid intimae-media thickness, cardio-ankle vascular index, ankle-brachial index, left ventricular mass index, Sokolow-Lyon index, Cornell voltage-duration product, and estimated glomerular filtration rate. Conclusion Endocan may not serve as a useful biomarker at asymptomatic vascular stages of hypertension, despite its role in indicating disease severity and inflammatory activation in advanced symptomatic CV and renal disease.
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- 2018
4. RELATIONSHIP BETWEEN CAROTID ARTERY DOPPLER FLOW VELOCITY AND EXTENT OF CORONARY ARTERY DISEASE
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Gündüz, Yasemin, Akdemir, Ramazan, Gündüz, Hüseyin, Perihan Varim, Lacin Tatli Ayhan, Çakar, Mehmet Akif, Vatan, Mehmet Bülent, Kılıç, Harun, Gunduz, Y, Akdemir, R, Gunduz, H, Varim, P, Ayhan, LT, Cakar, MA, Vatan, MB, Kilic, H, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Gündüz, Yasemin, Akdemir, Ramazan, Gündüz, Hüseyin, Çakar, Mehmet Akif, Vatan, Mehmet Bülent, and Kılıç, Harun
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cardiovascular system ,Cardiovascular System & Cardiology ,cardiovascular diseases - Abstract
Conclusion: To Patients with carotid artery disease have a high incidence of concomitant coronary artery disease, which is not different between the patients treated conservatively and stenting. In addition, the extension of coronary artery disease (not the presence) were associated with these two Doppler parameters.
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- 2019
5. Relationship Of Salusin-Alpha And Salusin-Beta Levels With Atherosclerosis In Patients Undergoing Haemodialysis
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Mehmet Bülent Vatan, Yakup Aksoy, Hamad Dheir, Seyyid Bilal Acikgoz, Savas Sipahi, Mehmet Yildirim, Ahmed Bilal Genc, Mustafa Altindiş, Sipahi, S, Genc, AB, Acikgoz, SB, Yildirim, M, Aksoy, YE, Vatan, MB, Dheir, H, Altindis, M, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Sipahi, Savaş, Dheir, Hamad, and Altındiş, Mustafa
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Turkey ,Carotid Artery, Common ,Inflammation ,Subgroup analysis ,030204 cardiovascular system & hematology ,Pulse Wave Analysis ,Carotid Intima-Media Thickness ,03 medical and health sciences ,0302 clinical medicine ,Renal Dialysis ,Internal medicine ,Diabetes mellitus ,medicine.artery ,General & Internal Medicine ,parasitic diseases ,Medicine ,Humans ,In patient ,030212 general & internal medicine ,Common carotid artery ,SALUSIN-ALPHA ,Pulse wave velocity ,SALUSIN-BETA ,Aged ,Aged, 80 and over ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,Atherosclerosis ,Cross-Sectional Studies ,Case-Control Studies ,Cardiology ,Intercellular Signaling Peptides and Proteins ,Original Article ,Female ,medicine.symptom ,business ,Biomarkers - Abstract
INTRODUCTION: In patients undergoing haemodialysis, cardiovascular mortality and morbidity, characterised by accelerated atherosclerosis and increased inflammation, are elevated. Salusins are newly defined molecules in the atherosclerotic processes, and while salusin-alpha (Sal-α) acts as an antiatherogenic factor, salusin-beta (Sal-β) has a proatherogenic role. Their roles are as yet undefined in patients undergoing haemodialysis. METHODS: In this cross-sectional study, salusin levels, carotid intima-media thickness (CIMT) from the common carotid artery and pulse wave velocity (PWV) were measured for 180 patients undergoing haemodialysis and 90 healthy controls. RESULTS: Mean Sal-α and Sal-β levels in patients undergoing haemodialysis (Sal-α: 726.4 ± 578.7 pg/mL; Sal-β: 1,080.4 ± 757.1 pg/mL) and healthy controls (Sal-α: 325.8 ± 303.7 pg/mL; Sal-β: 268.1 ± 409.0 pg/mL) were determined. Negative correlation was observed between Sal-α levels and CIMT (patients undergoing haemodialysis: r = −0.330, p < 0.0001; healthy controls: r = −0.223, p = 0.035) and PWV (patients undergoing haemodialysis: r = −0.210, p = 0.005; healthy controls: r = −0.378, p < 0.0001) in both groups. In patients undergoing haemodialysis, positive correlation was observed between Sal-β/Sal-α ratio and CIMT (r = 0.190, p = 0.012) and PWV (r = 0.155, p = 0.041). On subgroup analysis, Sal-α levels were found to be low in patients with diabetes mellitus. CONCLUSION: Patients undergoing haemodialysis have higher Sal-β and Sal-α levels, and their higher Sal-β/Sal-α ratio, in comparison with healthy controls, might have cardiovascular risk implications.
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- 2019
6. Usefulness of the platelet-to-lymphocyte ratio in predicting the severity of carotid artery stenosis in patients undergoing carotid angiography
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Mehmet Sevki Uyanık, Bilgehan Atılgan Acar, Ramazan Akdemir, Türkan Acar, Perihan Varim, Ceyhun Varim, Mehmet Bülent Vatan, Tezcan Kaya, Varim, C, Varim, P, Acar, BA, Vatan, MB, Uyanik, MS, Kaya, T, Acar, T, Akdemir, R, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Varım, Ceyhun, Acar, Bilgehan Atılgan, Vatan, Mehmet Bülent, Kaya, Tezcan, Acar, Türkan, and Akdemir, Ramazan
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Male ,medicine.medical_specialty ,Lymphocyte ,Research & Experimental Medicine ,030204 cardiovascular system & hematology ,Severity of Illness Index ,Asymptomatic ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Severity of illness ,Humans ,Medicine ,Carotid Stenosis ,Carotid artery stenosis ,Platelet ,Lymphocyte Count ,Aged ,Medicine(all) ,lcsh:R5-920 ,medicine.diagnostic_test ,Platelet Count ,business.industry ,Angiography ,Area under the curve ,General Medicine ,Middle Aged ,medicine.disease ,Confidence interval ,body regions ,Stenosis ,Carotid Arteries ,medicine.anatomical_structure ,ROC Curve ,Cardiology ,Female ,Radiology ,medicine.symptom ,lcsh:Medicine (General) ,business ,030217 neurology & neurosurgery - Abstract
Carotid artery stenosis (CAS) is primarily caused by atherosclerotic plaque. Progressive inflammation may contribute to the rupture of an atherosclerotic plaque. The platelet-to-lymphocyte ratio (PLR) is a new and simple marker that indicates inflammation. In this study, we aimed to investigate the use of the PLR to determine the severity of CAS. One hundred forty patients were chosen from among patients who underwent carotid angiography in our institution. Symptomatic patients with stenosis >50% in the carotid arteries and asymptomatic patients with stenosis >80% were diagnosed via carotid angiography as having critical stenosis. Patients were classified into two groups. Group 1 included patients who had critical CAS, whereas Group 2 included patients with noncritical CAS, as determined by carotid angiography. Correlations between the PLR and the severity of CAS were analyzed. There were no significant differences in sex and age between the two groups. The PLR was 162.5 +/- 84.7 in the noncritical CAS group patients and 94.9 +/- 60.3 in the critical CAS group patients (p < 0.0001). The PLR value of 117.1 had 89% sensitivity and 68% specificity for CAS [95% confidence interval, 0.043-0.159; area under the curve, 0.101 +/- 0.03)]. In this study, we have shown that PLR values may be associated with critical stenosis in at least one of the carotid arteries. Furthermore, PLR values may be used to predict critical stenosis in the carotid arteries. Copyright (C) 2016, Kaohsiung Medical University. Published by Elsevier Taiwan LLC.
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- 2016
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7. Use of neutrophil-lymphocyte ratio for risk stratification and relationship with time in therapeutic range in patients with nonvalvular atrial fibrillation: A pilot study
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Mehmet Bülent Vatan, Ramazan Akdemir, Kahraman Cosansu, Huseyin Gunduz, Cosansu, K, Vatan, MB, Gunduz, H, Akdemir, R, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Vatan, Mehmet Bülent, Gündüz, Hüseyin, and Akdemir, Ramazan
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Male ,medicine.medical_specialty ,Turkey ,Neutrophils ,Lymphocyte ,Clinical Investigations ,Pilot Projects ,030204 cardiovascular system & hematology ,Risk Assessment ,Severity of Illness Index ,Group B ,03 medical and health sciences ,Leukocyte Count ,0302 clinical medicine ,Internal medicine ,Thromboembolism ,Atrial Fibrillation ,medicine ,Humans ,Lymphocytes ,Stroke ,Aged ,Retrospective Studies ,Receiver operating characteristic ,business.industry ,Incidence ,fungi ,Area under the curve ,Warfarin ,Anticoagulants ,Atrial fibrillation ,General Medicine ,medicine.disease ,Thrombosis ,medicine.anatomical_structure ,Cardiology ,Cardiovascular System & Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,030217 neurology & neurosurgery ,medicine.drug ,Follow-Up Studies - Abstract
BACKGROUND: Atrial fibrillation is one of the most common abnormal heart rhythms. Neutrophil‐lymphocyte ratio (NLR) has emerged as a potential marker for the level of inflammation in cardiac disorders. HYPOTHESIS: NLR might be associated with thrombosis and bleeding risk scores and might predict cardioembolic risk in nonvalvular atrial fibrillation (NVAF) patients within the therapeutic international normalized ratio (INR). METHODS: We enrolled 272 patients taking warfarin for NVAF and classified them into 2 groups: Group A consisted of patients (n = 132) whose time in therapeutic range (TTR) was ≥65%, and Group B comprised patients (n = 139) whose TTR was
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- 2018
8. An investigation of pulse transit time as a blood pressure measurement method in patients undergoing carotid artery stenting
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Yusuf Can, Bilgehan Atılgan Acar, Ibrahim Kocyigit, Harun Kilic, Mehmet Bülent Vatan, Efe Edem, Murat Aksoy, Huseyin Gunduz, Nimet Uçaroğlu Can, Ramazan Akdemir, Can, Y, Kilic, H, Akdemir, R, Acar, B, Edem, E, Kocyigit, I, Vatan, MB, Aksoy, M, Can, N, Gunduz, H, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Can, Yusuf, Kılıç, Harun, Akdemir, Ramazan, Acar, Bilgehan Atılgan, Vatan, Mehmet Bülent, Aksoy, Muhammed Necati Murat, and Gündüz, Hüseyin
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Male ,medicine.medical_specialty ,medicine.medical_treatment ,Blood Pressure ,Pulse Wave Analysis ,030204 cardiovascular system & hematology ,Assessment and Diagnosis ,03 medical and health sciences ,0302 clinical medicine ,medicine.artery ,Internal medicine ,Heart rate ,Internal Medicine ,medicine ,Humans ,Carotid Stenosis ,cardiovascular diseases ,Aged ,Advanced and Specialized Nursing ,medicine.diagnostic_test ,business.industry ,General Medicine ,Pulse Transit Time ,medicine.disease ,Stenosis ,Mean blood pressure ,Blood pressure ,030228 respiratory system ,Cardiovascular System & Cardiology ,Cardiology ,Female ,Stents ,Internal carotid artery ,Carotid stenting ,Cardiology and Cardiovascular Medicine ,business ,Electrocardiography - Abstract
INTRODUCTION Pulse transit time (PTT) is the duration that a pulse wave takes to travel between two different arterial points, and it may be useful in estimating blood pressure. The aim of this study was to investigate the PTT during carotid artery stenting, as well as its value in blood pressure estimation. METHOD Thirty-four patients with critical carotid artery stenosis were enrolled in this study. The carotid PTT from the onset of the R-wave of electrocardiography to the pulse waveform at the carotid artery, obtained invasively during carotid artery catheterization, was measured. The carotid PTT was measured before and after stenting of the internal carotid artery. RESULTS The mean age was 70.4±8.0 years among the 34 patients enrolled (eight female patients, 21.9%). Measurements were obtained before and after carotid artery stenting. The heart rate (85.9±15.9 vs. 76.9±12.5 bpm, P
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- 2016
9. Insulin resistance in the patients with euthyroid Hashimoto thyroiditis
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Varım, Ceyhun, Kaya, Tezcan, Nalbant, Ahmet, Vatan, Mehmet Bülent, Yaylacı, Selçuk, Gökosmanoğlu, Feyzi, Tamer, Ali, Varim, C, Kaya, T, Varim, P, Nalbant, A, Vatan, MB, Yaylaci, S, Gokosmanoglu, F, Tamer, A, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Varım, Ceyhun, Kaya, Tezcan, Nalbant, Ahmet, Vatan, Mehmet Bülent, Yaylacı, Selçuk, Gökosmanoğlu, Feyzi, and Tamer, Ali
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endocrine system ,endocrine system diseases ,Research & Experimental Medicine - Abstract
Conclusion: High thyroid autoantibodies levels are related to high fasting blood glucose levels, insulin levels, lipid parameters, and Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) values. These findings indicate a possible relationship between insulin resistance and autoimmune thyroiditis and thyroid stimulating hormone levels. Patients with positive thyroid autoantibodies should be followed closely for diabetes mellitus and cardiovascular events.
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- 2017
10. Left ventricular twist was decreased in isolated left bundle branch block with preserved ejection fraction
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Mustafa Tarık Ağaç, Saadet Demirtaş, Harun Kilic, Huseyin Gunduz, Mehmet Bülent Vatan, Nurgül Keser, Sabiye Yilmaz, Ramazan Akdemir, Efe Edem, Yilmaz, S, Kilic, H, Agac, MT, Keser, N, Edem, E, Demirtas, S, Vatan, MB, Akdemir, R, Gunduz, H, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Kılıç, Harun, Ağaç, Mustafa Tarık, Keser, Nurgül, Vatan, Mehmet Bülent, Akdemir, Ramazan, and Gündüz, Hüseyin
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Male ,Speckle tracking echocardiography ,030204 cardiovascular system & hematology ,Ventricular Function, Left ,Ventricular Dysfunction, Left ,0302 clinical medicine ,Electromechanical coupling ,Twist ,Original Investigation ,education.field_of_study ,Ejection fraction ,Left bundle branch block ,Stroke volume ,Middle Aged ,Echocardiography ,cardiovascular system ,Cardiology ,Female ,speckle-tracking imaging ,Cardiology and Cardiovascular Medicine ,Editorial Comment ,medicine.medical_specialty ,animal structures ,Rotation ,Systole ,Heart Ventricles ,Bundle-Branch Block ,Population ,Diastole ,left ventricular function ,03 medical and health sciences ,Internal medicine ,medicine ,Humans ,left bundle branch block ,In patient ,cardiovascular diseases ,education ,Ventricular dyssynchrony ,Aged ,business.industry ,Stroke Volume ,medicine.disease ,Cross-Sectional Studies ,Logistic Models ,Case-Control Studies ,Cardiovascular System & Cardiology ,business ,030217 neurology & neurosurgery ,left ventricular twist - Abstract
Objective: Left ventricular (LV) rotation and twist play an important role in LV contraction and relaxation. Left bundle branch block (LBBB) deteriorates both diastolic and systolic functions. We evaluated the LV twist in patients with LBBB and preserved ejection fraction (EF) (>50%) to determine twist as a potential marker for subtle myocardial dysfunction. Methods: This observational cross-sectional study included 34 LBBB patients with preserved EF who were free from ischemic and valvular disease (Group 1) and 36 healthy controls (Group 2). All patients underwent 2-D Doppler and 2-D speckle tracking echocardiography. LV apical, basal rotation, and twist were evaluated in both groups and compared accordingly. In addition, subjects were dichotomized considering the median twist value of the study population. Binary logistic regression analysis was performed to determine the independent variables associated with inframedian twist. Results: Baseline clinical characteristics were similar in LBBB patients and controls. Mean apical rotation (2.5°±1.9° vs. 4.4°±2.9°; p=0.002), basal rotation (-2.9°±2.3° vs. -4.1°±2.7°; p=0.05), and twist (5.4°±3° vs. 8.6°±3.3°; p
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- 2017
11. Comparison of closed-cell and hybrid-cell stent designs in carotid artery stenting: clinical and procedural outcomes
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Harun Kilic, Alptug Tokatli, Ersan Tatli, Huseyin Gunduz, Mehmet Bülent Vatan, Mustafa Tarık Ağaç, Ramazan Akdemir, Tatli, E, Tokatli, A, Vatan, MB, Agac, MT, Gunduz, H, Akdemir, R, Kilic, H, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Tatlı, Ersan, Vatan, Mehmet Bülent, Ağaç, Mustafa Tarık, Gündüz, Hüseyin, Akdemir, Ramazan, and Kılıç, Harun
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medicine.medical_specialty ,Carotid arteries ,medicine.medical_treatment ,lcsh:Medicine ,030204 cardiovascular system & hematology ,carotid artery stenosis ,closed cell ,outcomes ,hybrid cell ,03 medical and health sciences ,0302 clinical medicine ,medicine.artery ,medicine ,030212 general & internal medicine ,Myocardial infarction ,cardiovascular diseases ,Adverse effect ,Stroke ,Original Paper ,carotid artery stenting ,business.industry ,stent design ,lcsh:R ,Stent ,Vasospasm ,medicine.disease ,equipment and supplies ,Surgery ,surgical procedures, operative ,Closed cell ,cardiovascular system ,Cardiovascular System & Cardiology ,Internal carotid artery ,Cardiology and Cardiovascular Medicine ,business - Abstract
Introduction: Carotid artery stenting (CAS) is a promising alternative to surgery in high-risk patients. However, the impact of stent cell design on outcomes in CAS is a matter of continued debate. Aim : To compare the periprocedural and clinical outcomes of different stent designs for CAS with distal protection devices. Material and methods : All CAS procedures with both closed- and hybrid-cell stents performed at our institution between February 2010 and December 2015 were analyzed retrospectively. Adverse events were defined as death, major stroke, minor stroke, transient ischemic attack and myocardial infarction. Periprocedural and 30-day adverse events and internal carotid artery (ICA) vasospasm rates were compared between the closed-cell and hybrid-cell stent groups. Results : The study included 234 patients comprising 146 patients with a closed-cell stent (Xact stent, Abbott Vascular) (mean age: 68.5 ±8.6; 67.1% male) and 88 patients with a hybrid-cell stent (Cristallo Ideale, Medtronic) (mean age: 67.2 ±12.8; 68.2% male). There was no significant difference between the groups with respect to periprocedural or 30-day adverse event rates. While there was no difference in terms of tortuosity index between the groups, there was a higher procedural ICA vasospasm rate in the closed-cell stent group (35 patients, 23%) compared with the hybrid-cell stent group (10 patients, 11%) (p = 0.017). Conclusions : The results of this study showed no significant difference in the clinical adverse event rates after CAS between the closed-cell stent group and the hybrid-cell stent group. However, procedural ICA vasospasm was more common in the closed-cell stent group.
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- 2017
12. Relation between the GRACE score and severity of atherosclerosis in acute coronary syndrome
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Mehmet Bülent Vatan, Ercan Aydin, Nurgül Keser, Ramazan Akdemir, Huseyin Gunduz, Salih Sahinkus, Mehmet Akif Cakar, Cakar, MA, Sahinkus, S, Aydin, E, Vatan, MB, Keser, N, Akdemir, R, Gunduz, H, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Çakar, Mehmet Akif, Vatan, Mehmet Bülent, Keser, Nurgül, Akdemir, Ramazan, and Gündüz, Hüseyin
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Adult ,Male ,Risk ,Coronary angiography ,medicine.medical_specialty ,Acute coronary syndrome ,GRACE score ,Gensini score ,Coronary Artery Disease ,Coronary Angiography ,Risk Assessment ,Severity of Illness Index ,Coronary artery disease ,Risk groups ,Internal medicine ,medicine ,Humans ,In patient ,Registries ,Acute Coronary Syndrome ,Aged ,Aged, 80 and over ,Framingham Risk Score ,business.industry ,Multivessel disease ,Middle Aged ,medicine.disease ,Cardiology ,Female ,Risk of death ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background: Patients with non-ST-elevation acute coronary syndrome are heterogeneous in terms of clinical presentation and immediate- and long-term risk of death or non-fatal ischemic events. The aim of the present study was to evaluate the relationship between the Global Registry of Acute Coronary Events (GRACE) score and severity of coronary artery disease angiographically evaluated by Gensini score in patients with non-ST-elevation acute coronary syndrome. Methods: A total of 245 patients with non-ST-elevation acute coronary syndrome were enrolled to the study. Based on the GRACE risk score classification system, the patients were divided into low- (n = 97, 39.6%), intermediate- (n = 84, 343%), and high- (n = 64, 26.1%) risk groups. All patients underwent coronary angiography within five days after admission. Results: The Gensini scores were 26 +/- 29 in the low-risk group, 29 +/- 19 in the intermediate-risk group, and 38 +/- 23 in the high-risk group (p = 0.016). The low-risk group was significantly different from the high-risk group (p = 0.013), and the difference from the intermediate-risk group almost reached significance. Normal, noncritical, one and two, or multivessel disease were identified in 15 (6.1%), 31 (12.7%), 75 (30.6%), and 124 (50.6%) patients, respectively. The prevalence of multivessel disease was 28% in the low-risk group, 30% in the intermediate-risk group, and 42% in the high-risk group. The high-risk group was significantly different from the low-risk group (p < 0.01). Conclusion: Our study demonstrates that the GRACE score has significant value for assessing the severity and extent of coronary artery stenosis in patients with non-ST-elevation acute coronary syndrome. (C) 2013 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
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- 2014
13. Association Between Nonalcoholic Fatty Liver Disease and Coronary Artery Disease Complexity in Patients With Acute Coronary Syndrome
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Gökhan Çavuşoğlu, Hakan Erkan, Mehmet Bülent Vatan, Ümit Menteşe, Şükrü Çelik, Ayşegül Karadeniz, Süret Ağaç, Hüseyin Bektaş, Mustafa Oguz Varol, Mustafa Tarık Ağaç, Zeydin Acar, Levent Korkmaz, Agac, MT, Korkmaz, L, Cavusoglu, G, Karadeniz, AG, Agac, S, Bektas, H, Erkan, H, Varol, MO, Vatan, MB, Acar, Z, Mentese, U, Celik, S, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Ağaç, Mustafa Tarık, and Vatan, Mehmet Bülent
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Acute coronary syndrome ,Univariate analysis ,medicine.medical_specialty ,business.industry ,nutritional and metabolic diseases ,Odds ratio ,medicine.disease ,digestive system ,Gastroenterology ,digestive system diseases ,Confidence interval ,Coronary artery disease ,Internal medicine ,Nonalcoholic fatty liver disease ,Cardiovascular System & Cardiology ,Medicine ,In patient ,Stage (cooking) ,Cardiology and Cardiovascular Medicine ,business - Abstract
Nonalcoholic fatty liver disease (NAFLD) is highly prevalent in patients with acute coronary syndrome (ACS). We assessed the association between NAFLD and SYNTAX Score (SS) in patients with ACS. Eighty consecutive patients with ACS were enrolled. Patients were evaluated using ultrasound to detect NAFLD and hepatosteatosis stage. The prevalence of NAFLD was 81.2%; median SS was 15. The SS was significantly higher in patients with NAFLD (18 ± 8 vs. 11 ± 5, P = .001). Univariate analysis showed that the stage of NAFLD correlated with SS ( r = .6, P < .001). In multivariate binary logistic analysis, increased age (odds ratio [OR], 1.05; 95% confidence interval [CI],1.00-1.10) and presence of NAFLD (OR, 13.20; 95% CI, 2.52-69.15) were independent factors associated with supramedian SS. In conclusion, among patients with ACS, those with NAFLD have more complex CAD as assessed by SS.
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- 2013
14. Predictors of periprocedural complications of carotid artery stenting - a multivariate analysis of a single-centre experience
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Harun Kilic, Ceyhun Varim, Mehmet Bülent Vatan, Mustafa Tarık Ağaç, Ramazan Akdemir, Huseyin Gunduz, Bilgehan Atılgan Acar, Yusuf Can, Ersan Tatli, Murat Aksoy, Vatan, MB, Acar, BA, Aksoy, M, Can, Y, Varim, C, Agac, MT, Kilic, H, Tatli, E, Gunduz, H, Akdemir, R, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Vatan, Mehmet Bülent, Acar, Bilgehan Atılgan, Aksoy, Muhammed Necati Murat, Can, Yusuf, Varım, Ceyhun, Ağaç, Mustafa Tarık, Kılıç, Harun, Tatlı, Ersan, Gündüz, Hüseyin, and Akdemir, Ramazan
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Male ,medicine.medical_specialty ,Multivariate analysis ,Turkey ,Computed Tomography Angiography ,medicine.medical_treatment ,Carotid endarterectomy ,Transient ischaemic attacks ,Logistic regression ,Risk Assessment ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Odds Ratio ,medicine ,Humans ,Carotid Stenosis ,Stroke ,Aged ,Ultrasonography, Doppler, Duplex ,Chi-Square Distribution ,business.industry ,Incidence (epidemiology) ,Angioplasty ,Age Factors ,Amaurosis fugax ,Middle Aged ,medicine.disease ,Surgery ,Stenosis ,Logistic Models ,Treatment Outcome ,Multivariate Analysis ,Cardiovascular System & Cardiology ,Female ,Stents ,Radiology ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Magnetic Resonance Angiography ,030217 neurology & neurosurgery - Abstract
Abstract. Background: Carotid artery stenting (CAS) is currently used as an alternative treatment to carotid endarterectomy (CEA). The objective of this study was to analyse our 5-year experience performing CAS. Secondarily, we sought to determine independent risk factors which predict periprocedural complications. Patients and Methods: A total of 146 patients who underwent 153 CAS procedures were analysed. The majority of patients (123, 84.2%) had symptomatic carotid stenosis. Demographic and interventional data, angiographic lesion characteristics, and periprocedural complications were recorded. Using univariate and multivariate logistic regression analyses, risk factors associated with adverse clinical outcomes were determined. Results: Periprocedural neurological complications, including four (2.7 %) major strokes, three (2 %) transient ischaemic attacks, one (0.7%) amaurosis fugax, and two (1.3 %) cases of hyperperfusion syndrome occurred in ten (6.8%) patients. The incidence of periprocedural complications significantly increased in female patients (r = 0.214, p = 0.009) and patients with longer lesions (r = 0.183, p = 0.027), contralateral stenosis ≥50 % (r = 0.222, p = 0.007), the presence of complicated plaques (r = 0.478, p < 0.001) and inadequate glycaemic control (r = 0.259, p = 0.002). Multivariate regression analysis also determined four variables to be potential independent risk factors for 30-day adverse events: higher age (Odds ratio [OR] = 1.283; 95 % CI, 1.051 to 1.566, p = 0.014); longer lesions (OR = 1.459, 95 % CI, 1.124 to 1.893, p = 0.004); higher tortuosity index (OR = 1.015, 95 % CI, 1.001 to 1.030, p = 0.034), and the presence of complicated plaque morphology (OR = 4.321, 95 % CI, 1.621 to 10.23, p = 0.001). Conclusions: Patient and lesion characteristics including age, lesion length, complicated plaque morphology and tortuosity index, may be associated with periprocedural complications.
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- 2016
15. Echocardiographic Evaluation of Biventricular Function in Patients with Euthyroid Hashimoto's Thyroiditis
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Sabiye Yilmaz, Mustafa Tarık Ağaç, Mehmet Akif Cakar, Ceyhun Varim, Murat Aksoy, Harun Kilic, Perihan Varim, Mehmet Bülent Vatan, Hakan Erkan, Ramazan Akdemir, Huseyin Gunduz, Vatan, MB, Varim, C, Agac, MT, Varim, P, Cakar, MA, Aksoy, M, Erkan, H, Yilmaz, S, Kilic, H, Gunduz, H, Akdemir, R, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Vatan, Mehmet Bülent, Varım, Ceyhun, Ağaç, Mustafa Tarık, Çakar, Mehmet Akif, Aksoy, Muhammed Necati Murat, Kılıç, Harun, Gündüz, Hüseyin, and Akdemir, Ramazan
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Male ,Thyroiditis ,medicine.medical_specialty ,Heart Ventricles ,Hashimoto Disease ,Ventricular Function, Left ,Biventricular function ,Internal medicine ,General & Internal Medicine ,Ventricular Dysfunction ,Humans ,Medicine ,Euthyroid ,In patient ,Original Paper ,Ejection fraction ,business.industry ,General Medicine ,Fractional shortening ,Left ventricle ,Middle Aged ,Control subjects ,medicine.disease ,Echocardiography, Doppler ,Endocrinology ,Echocardiography ,Cardiology ,Right ventricle ,Female ,Tei index ,Tricuspid Valve ,business - Abstract
Objective: The aim of this study was to evaluate the left (LV) and right (RV) ventricular function in euthyroid Hashimoto's thyroiditis (eHT) patients. Subjects and Methods: Forty-five patients diagnosed with eHT and 45 age- and gender-matched control subjects were enrolled in this study. Echocardiographic parameters reflecting RV and LV functions such as chamber dimensions, ejection fraction, fractional shortening, conventional and tissue Doppler-derived early and late filling velocities (E, A, E', A'), isovolumic relaxation (IVRT) and contraction (IVCT) times, ejection time (ET), deceleration time (DT), Tei index, pulmonary acceleration time (PAcT) and tricuspid annular plane systolic excursion (TAPSE) of patients with eHT were compared to those of control subjects using the paired-samples t test or Wilcoxon signed-rank test. Results: Regarding the LV function, compared to the controls patients with eHT had a higher LV-Tei index (0.6 ± 0.2 vs. 0.4 ± 0.1, p < 0.001), higher DT (p < 0.001) and IVRT (p < 0.001) values, and higher E/E' ratios (p = 0.04). In contrast, the peak E wave velocity (p = 0.02), E/A ratio (p = 0.01) and ET (p = 0.02) were significantly lower in the eHT group than amongst the controls. The RV, Tei index (0.40 ± 0.11 vs. 0.28 ± 0.07, p < 0.001), TAPSE (2.0 ± 0.3 vs. 2.2 ± 0.2 mm, p < 0.001), PAcT (124.3 ± 22.6 vs. 149.4 ± 18.3 ms, p < 0.001), A' (p = 0.007) and IVCT (p = 0.001) were significantly higher in patients with eHT than the controls. However, the tricuspid E/A ratio (p = 0.01), E' (p = 0.03) and E'/A' ratio (p = 0.001) were significantly lower in the eHT patients than the control group. Conclusions: This study demonstrated that both RV and LV functions were impaired in patients with eHT.
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- 2016
16. Percutaneous approach to the treatment of a totally occluded abdominal aortic stent graft
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M Tarik Agac, Murat Aksoy, M Turker Pabuccu, Yusuf Can, Alptug Tokatli, Ersan Tatli, M. Bulent Vatan, Tatli, E, Tokatli, A, Vatan, MB, Aksoy, M, Can, Y, Pabuccu, MT, Agac, MT, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Tatlı, Ersan, and Can, Yusuf
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medicine.medical_specialty ,medicine.medical_treatment ,Arterial Occlusive Diseases ,030204 cardiovascular system & hematology ,Aortic stent ,Percutaneous angioplasty ,03 medical and health sciences ,0302 clinical medicine ,Angioplasty ,medicine.artery ,Occlusion ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Aorta, Abdominal ,030212 general & internal medicine ,cardiovascular diseases ,Advanced and Specialized Nursing ,Aorta ,business.industry ,General Medicine ,Middle Aged ,Percutaneous approach ,Surgery ,surgical procedures, operative ,Diffuse disease ,cardiovascular system ,Cardiovascular System & Cardiology ,Female ,Stents ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,Safety Research ,Aortic Aneurysm, Abdominal - Abstract
Aorto femoral bypass is usually the recommended therapy for diffuse disease involving the aorta and iliac arteries. In this case report, a case involving a chronic endovascular abdominal aortic stent graft occlusion in which percutaneous angioplasty was performed via a transbrachial and transfemoral approach is presented. This case emphasized that occlusion of an endovascular abdominal aortic stent graft can also be treated, primarily, with an endovascular technique.
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- 2016
17. Evaluation of metallothionein-1, metallothionein-2, lipid peroxidation and trace elements status in the progression of the spontaneous mitral chordae tendineae rupture patients
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Nurten Bahtiyar, Mahmut Alp Kılıç, Dursun Çayan Akkoyun, Ali Riza Kiziler, Hakan Cinemre, Fatma Behice Serinkan Cinemre, Birsen Aydemir, Mehmet Bülent Vatan, Ramazan Akdemir, Aydemir, B, Cinemre, FBS, Cinemre, H, Kiziler, AR, Akdemir, R, Vatan, MB, Kilic, MA, Bahtiyar, N, Akkoyun, DC, Sakarya Üniversitesi/Tıp Fakültesi/Temel Tıp Bilimleri Bölümü, Cinemre, Fatma Behice, Cinemre, Hakan, Akdemir, Ramazan, and Vatan, Mehmet Bülent
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Pathology ,medicine.medical_specialty ,business.industry ,Clinical Biochemistry ,Biochemistry ,Inorganic Chemistry ,Lipid peroxidation ,Trace (semiology) ,chemistry.chemical_compound ,Endocrinology & Metabolism ,medicine.anatomical_structure ,chemistry ,Internal medicine ,Cardiology ,Medicine ,Metallothionein ,Chordae tendineae ,business - Abstract
Objective: The aim of the present study was to investigate whether copper, zinc and iron levels and copper/zinc, iron/zinc, iron/copper ratios in serum and erythrocytes are associated with lipid oxidation levels, metallothionein-1 (MT-1), and metallothionein-2 (MT-2) levels in plasma in the context of pathogenesis of the mitral chordae tendineae rupture (MCTR). Methods: 65 subjects who were identical in demographic characteristics' were selected for the study; 33 with MCTR patients, and 32 healthy control subjects. The levels of MT-1, MT-2, and malondialdehyde as measure of lipid oxidation, and trace elements were determined by enzyme-linked immunosorbent assay, spectrophotometric method, and inductively coupled plasma optical emission spectrometry, respectively. Results: Serum zinc levels were found to be lower in the patients' group when compared to control group. The copper and iron levels in serum, MT-1, MT-2; malondialdehyde levels in plasma, iron and malondialdehyde levels in erythrocytes; serum copper/zinc and iron/zinc ratios were found to be higher in the patients' group when compared to controls. Conclusions: We conclude that the changes of oxidant antioxidant system balance and trace element status may contribute to the etiopathogenesis of MCTR.
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- 2016
18. Comparison between primary angioplasty and thrombolytic therapy on erectile dysfunction after acute ST elevation myocardial infarction
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Harun Kilic, Ramazan Akdemir, Mehmet Bülent Vatan, Ekrem Yeter, Levent Sagnak, Hamit Ersoy, Mustafa Mücahit Balcı, Özlem Karakurt, Salih Orcan, Nihat Karakoyunlu, Akdemir, R, Karakurt, O, Orcan, S, Karakoyunlu, N, Balci, MM, Sagnak, L, Ersoy, H, Vatan, MB, Kilic, H, Yeter, E, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Kılıç, Harun, Vatan, Mehmet Bülent, and Akdemir, Ramazan
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Adult ,Male ,medicine.medical_specialty ,Urology ,medicine.medical_treatment ,Myocardial Infarction ,Primary angioplasty ,Electrocardiography ,Erectile Dysfunction ,Internal medicine ,Angioplasty ,medicine ,Humans ,Thrombolytic Agent ,Thrombolytic Therapy ,cardiovascular diseases ,Myocardial infarction ,business.industry ,General Medicine ,Blood flow ,Urology & Nephrology ,Middle Aged ,medicine.disease ,Erectile dysfunction ,medicine.anatomical_structure ,Cardiology ,Original Article ,business ,Sexual function ,Artery - Abstract
Acute ST elevation myocardial infarction has high mortality and morbidity rates. The majority of patients with this condition face erectile dysfunction in addition to other health problems. In this study, we aimed to investigate the effects of two different reperfusion strategies, primary angioplasty and thrombolytic therapy, on the prevalence of erectile dysfunction after acute myocardial infarction. Of the 71 patients matching the selection criteria, 45 were treated with primary coronary angioplasty with stenting, and 26 were treated with thrombolytic agents. Erectile function was evaluated using the International Index of Erectile Function in the hospital to characterize each patient's sexual function before the acute myocardial infarction and 6 months after the event. The time required to restore blood flow to the artery affected by the infarct was found to be associated with the occurrence of erectile dysfunction after acute myocardial infarction. The increase in the prevalence of erectile dysfunction after acute myocardial infarction was 44.4% in the angioplasty group and 76.9% in the thrombolytic therapy group (P=0.008). In conclusion, this study has shown that reducing the time of reperfusion decreases the erectile dysfunction prevalence, and primary angioplasty is superior to thrombolytic therapy for decreasing the prevalence of erectile dysfunction after acute myocardial infarction. Asian Journal of Andrology (2012) 14, 784-787; doi:10.1038/aja.2012.41; published online 16 July 2012
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- 2012
19. Changes in Serum Natriuretic Peptide Levels after Percutaneous Closure of Small to Moderate Ventricular Septal Defects
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Sani Namik Murat, Ramazan Akdemir, Ibrahim Kocayigit, Ekrem Yeter, Mustafa Tarık Ağaç, Harun Kilic, Orhan Bulut, Yüksel Kaya, Zeydin Acar, Huseyin Gunduz, M. Bulent Vatan, M. Akif Cakar, Kaya, Y, Akdemir, R, Gunduz, H, Murat, S, Bulut, O, Kocayigit, I, Vatan, MB, Cakar, MA, Yeter, E, Kilic, H, Agac, MT, Acar, Z, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Akdemir, Ramazan, Gündüz, Hüseyin, Vatan, Mehmet Bülent, Çakar, Mehmet Akif, Kılıç, Harun, and Ağaç, Mustafa Tarık
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Heart Septal Defects, Ventricular ,Male ,medicine.medical_specialty ,Percutaneous ,Article Subject ,Septal Occluder Device ,medicine.drug_class ,lcsh:Medicine ,lcsh:Technology ,General Biochemistry, Genetics and Molecular Biology ,Defect closure ,Internal medicine ,Natriuretic Peptide, Brain ,medicine ,Natriuretic peptide ,Humans ,In patient ,cardiovascular diseases ,lcsh:Science ,Adverse effect ,General Environmental Science ,lcsh:T ,business.industry ,Cardiovascular Surgical Procedures ,lcsh:R ,General Medicine ,Middle Aged ,Plastic Surgery Procedures ,medicine.disease ,Brain natriuretic peptide ,Treatment Outcome ,Heart failure ,Clinical Study ,Cardiology ,Science & Technology - Other Topics ,lcsh:Q ,business ,Biomarkers - Abstract
Background. B-type natriuretic peptide has been shown to be a very sensitive and specific marker of heart failure. In this study, we aimed to investigate the effect of percutaneous closure of ventricular septal defects with Amplatzer septal occluders on brain natriuretic peptide levels.Methods. Between 2008 and 2011, 23 patients underwent successfully percutaneous ventricular septal defect closure in 4 cardiology centers. Brain natriuretic peptide levels were measured in nine patients (4 male, mean ages were ) who underwent percutaneous closure with Amplatzer occluders for membranous or muscular ventricular septal defects were enrolled in the study. Brain natriuretic peptide levels were measured one day before and one month after the closure. Patients were evaluated clinically and by echocardiography one month after the procedure.Results. Percutaneous closures of ventricular septal defects were successfully performed in all patients. There was not any significant adverse event in patients group during followup. Decrease in brain natriuretic peptide levels after closure were statistically significant ( versus , ).Conclusion. Brain Natriuretic Peptide levels are elevated in patients with ventricular septal defects as compared to controls. Percutaneous closure of Ventricular Septal Defect with Amplatzer occluders decreases the BNP levels.
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- 2012
20. Prevention of Bleeding in Atrial Fibrillation
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Cagin M. Ureyen, M. Bulent Vatan, Gündüz, Hüseyin, Sharan P. Sharma, Ureyen, CM, Vatan, MB, Gunduz, H, Sharma, SP, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, and Gündüz, Hüseyin
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medicine.medical_specialty ,MEDLINE ,Hemorrhage ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Text mining ,Risk Factors ,General & Internal Medicine ,Internal medicine ,Atrial Fibrillation ,Humans ,Medicine ,030212 general & internal medicine ,Stroke ,business.industry ,Warfarin ,Anticoagulants ,Atrial fibrillation ,General Medicine ,medicine.disease ,Cardiology ,business ,medicine.drug - Abstract
PMID = 28276225
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- 2017
21. The Circulating Levels of Selenium, Zinc, Midkine, Some Inflammatory Cytokines, and Angiogenic Factors in Mitral Chordae Tendineae Rupture
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Ali Riza Kiziler, F. Behice Cinemre, Selim Ogut, Ramazan Akdemir, Gönül Gürol, M. Bulent Vatan, Hakan Cinemre, Nurten Bahtiyar, M. Emin Buyukokuroglu, Birsen Aydemir, Aydemir, B, Akdemir, R, Vatan, MB, Cinemre, FB, Cinemre, H, Kiziler, AR, Bahtiyar, N, Buyukokuroglu, ME, Gurol, G, Ogut, S, Sakarya Üniversitesi/Tıp Fakültesi/Temel Tıp Bilimleri Bölümü, Aydemir, Birsen, Akdemir, Ramazan, Vatan, Mehmet Bülent, Cinemre, Fatma Behice, Cinemre, Hakan, Büyükokuroğlu, Mehmet Emin, and Gürol Çiftci, Gönül
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Adult ,Male ,Vascular Endothelial Growth Factor A ,medicine.medical_specialty ,Pathology ,Angiogenesis ,Endocrinology, Diabetes and Metabolism ,Clinical Biochemistry ,Context (language use) ,Inflammation ,Biochemistry ,Proinflammatory cytokine ,Inorganic Chemistry ,Pathogenesis ,Selenium ,Endocrinology & Metabolism ,Internal medicine ,medicine ,Humans ,Nerve Growth Factors ,Midkine ,Mitral regurgitation ,biology ,Rupture, Spontaneous ,business.industry ,Biochemistry (medical) ,Mitral Valve Insufficiency ,General Medicine ,Middle Aged ,Zinc ,medicine.anatomical_structure ,biology.protein ,Cardiology ,Cytokines ,Female ,Chordae tendineae ,medicine.symptom ,business - Abstract
Chordae tendineae rupture process is associated with increased production of inflammatory and angiogenesis mediators in connective tissues, which contributes to chronic inflammation and pathogenesis of degenerative chordae. A few trace elements are known to possess antioxidant, anti-inflammatory, and antiangiogenic properties. Therefore, the aim of this study was to determine whether zinc, selenium, midkine (MK), interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-alpha), vascular endothelial growth factor-A (VEGF-A), platelet-derived growth factor-BB (PDGF-BB), and reduced glutathione (GSH) levels are associated with inflammation and angiogenesis processes in the context of a potential etiology causing aggravation of mitral regurgitation and/or ruptured chordae tendineae. Seventy-one subjects comprising 34 patients with mitral chordae tendineae rupture (MCTR) and 37 healthy controls diagnosed on the basis of their clinical profile and transthoracic echocardiography were included in this study. The levels of GSH, MK, selenium, and zinc were found to be lower in the patients group when compared to control group. There were no significant difference in plasma TNF-alpha, IL-1 beta, IL-6, IL-8, VEGF-A, and PDGF-BB levels between two groups. There were positive significant correlations between MK and GSH, MK, and selenium levels in patients with MCTR. According to our data in which selenium, zinc, MK, and GSH decreased in MCTR patients, inflammatory response, oxidative stress, and trace element levels may contribute to etiopathogenesis of mitral regurgitation and/or ruptured chordae tendineae.
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- 2015
22. DNA Repair Gene Polymorphism and the Risk of Mitral Chordae Tendineae Rupture
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Unal Erkorkmaz, Mehmet Akif Cakar, Harun Kilic, Aysel Kalayci Yigin, Mehmet Bülent Vatan, Keziban Karacan, Muhammed Necati Murat Aksoy, Süleyman Kaleli, Ramazan Akdemir, Yigin, AK, Vatan, MB, Akdemir, R, Aksoy, MNM, Cakar, MA, Kilic, H, Erkorkmaz, U, Karacan, K, Kaleli, S, Sakarya Üniversitesi/Tıp Fakültesi/Temel Tıp Bilimleri Bölümü, Kalaycı Yiğin, Aysel, Vatan, Mehmet Bülent, Akdemir, Ramazan, Aksoy, Muhammed Necati Murat, Çakar, Mehmet Akif, Kılıç, Harun, Erkorkmaz, Ünal, Karacan, Keziban, and Kaleli, Süleyman
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Adult ,Male ,Heterozygote ,Article Subject ,DNA repair ,Clinical Biochemistry ,Heart Valve Diseases ,Biology ,Polymorphism, Single Nucleotide ,law.invention ,Andrology ,law ,Genotype ,Genetics ,Pathology ,Humans ,Molecular Biology ,Genotyping ,Gene ,Polymerase chain reaction ,Aged ,lcsh:R5-920 ,Biochemistry (medical) ,Case-control study ,Heterozygote advantage ,General Medicine ,Middle Aged ,Molecular biology ,DNA-Binding Proteins ,Case-Control Studies ,Chordae Tendineae ,Mitral Valve ,Female ,Restriction fragment length polymorphism ,lcsh:Medicine (General) ,Research Article - Abstract
Polymorphisms in Lys939Gln XPC gene may diminish DNA repair capacity, eventually increasing the risk of carcinogenesis. The aim of the present study was to evaluate the significance of polymorphism Lys939Gln in XPC gene in patients with mitral chordae tendinea rupture (MCTR). Twenty-one patients with MCTR and thirty-seven age and sex matched controls were enrolled in the study. Genotyping of XPC gene Lys939Gln polymorphism was carried out using polymerase chain reaction- (PCR-) restriction fragment length polymorphism (RFLP). The frequencies of the heterozygote genotype (Lys/Gln-AC) and homozygote genotype (Gln/Gln-CC) were significantly different in MCTR as compared to control group, respectively (52.4% versus 43.2%,p=0.049; 38.15% versus 16.2%,p=0.018). Homozygote variant (Gln/Gln) genotype was significantly associated with increased risk of MCTR (OR = 2.059; 95% CI: 1.097–3.863;p=0.018). Heterozygote variant (Lys/Gln) genotype was also highly significantly associated with increased risk of MCTR (OR = 1.489; 95% CI: 1.041–2.129;p=0.049). The variant allele C was found to be significantly associated with MCTR (OR = 1.481; 95% CI: 1.101–1.992;p=0.011). This study has demonstrated the association of XPC gene Lys939Gln polymorphism with MCTR, which is significantly associated with increased risk of MCTR.
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- 2015
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23. Relationship between CHA2DS2-VASc score and atrial electromechanical function in patients with paroxysmal atrial fibrillation: A pilot study
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Murat Aksoy, Mustafa Tarık Ağaç, Sabiye Yilmaz, Hakan Erkan, Mehmet Bülent Vatan, Saadet Demirtaş, Mehmet Akif Cakar, Ceyhun Varim, Huseyin Gunduz, Ramazan Akdemir, Vatan, MB, Yilmaz, S, Agac, MT, Cakar, MA, Erkan, H, Aksoy, M, Demirtas, S, Varim, C, Akdemir, R, Gunduz, H, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Vatan, Mehmet Bülent, Ağaç, Mustafa Tarık, Çakar, Mehmet Akif, Aksoy, Muhammed Necati Murat, Varım, Ceyhun, Akdemir, Ramazan, and Gündüz, Hüseyin
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Adult ,Male ,medicine.medical_specialty ,Paroxysmal atrial fibrillation ,Pilot Projects ,Risk Assessment ,Severity of Illness Index ,Risk groups ,Internal medicine ,Atrial Fibrillation ,Medicine ,Humans ,In patient ,Risk stratification ,Aged ,Univariate analysis ,Framingham Risk Score ,business.industry ,Atrial fibrillation ,Atrial Remodeling ,Middle Aged ,medicine.disease ,Remodeling ,Stroke ,ROC Curve ,Echocardiography ,CHA2DS2–VASc score ,Cardiology ,Cardiovascular System & Cardiology ,Atrial Function, Left ,Female ,business ,Cardiology and Cardiovascular Medicine - Abstract
A B S T R A C T Background: CHA2DS2-VASc score is the most widely preferred method for prediction of stroke risk in patients with atrial fibrillation. We hypothesized that CHA2DS2-VASc score may represent atrial remodeling status, and therefore echocardiographic evaluation of left atrial electromechanical remodeling can be used to identify patients with high risk. Methods: A total of 65 patients who had documented diagnosis of paroxysmal atrial fibrillation (PAF) were divided into three risk groups according to the CHA2DS2-VASc score: patients with low risk (score = 0, group 1), with moderate risk (score = 1, group 2), and with high risk score (score 2, group 3). We compared groups according to atrial electromechanical intervals and left atrium mechanical functions. Results: Atrial electromechanical intervals including inter-atrial and intra-atrial electromechanical delay were not different between groups. However, parameters reflecting atrial mechanical functions including LA phasic volumes (Vmax, Vmin and Vp) were significantly higher in groups 2 and 3 compared with group 1. Likewise, LA passive emptying volume (LATEV) in the groups 2 and 3 was significantly higher than low-risk group (14.12 8.13 ml/m 2 , 22.36 8.78 ml/m 2 , 22.89 7.23 ml/m 2 , p: 0.031). Univariate analysis demonstrated that Vmax, Vmin and Vp were significantly correlated with CHA2DS2-VASc score (r = 0.428, r = 0.456, r = 0.451 and p < 0.001). Also, LATEV (r = 0.397, p = 0.016) and LA active emptying volume (LAAEV) (r = 0.281, p = 0.023) were positively correlated with CHA2DS2-VASc score. In the ROC analysis, Vmin 11 ml/m 2 has the highest predictive value for CHA2DS2-VASc score 2 (88% sensitivity and 89% specificity; ROC area 0.88, p < 0.001, CI [0.76–0.99]). Conclusion: Echocardiographic evaluation of left atrial electromechanical function might represent a useful method to identify patients with high risk.
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- 2014
24. COMPLETE PERCUTANEOUS REVASCULARIZATION OF A SINGLE CORONARY OSTIUM IN A 84 YEAR-OLD WOMAN
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Vatan, Mehmet Bülent, Gündüz, Hüseyin, Akdemir, Ramazan, Vatan, MB, Gunduz, H, Akdemir, R, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Vatan, Mehmet Bülent, Gündüz, Hüseyin, and Akdemir, Ramazan
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Geriatrics & Gerontology ,cardiovascular diseases - Abstract
Coronary arteries originating from a single coronary ostium is a rare condition. The incidence is 0.03% of patient undergoing diagnostic coronary angiography. Approximately 20 possible variations of single coronary artery have been described. Of these, single coronary artery arising from the right sinus of valsalva are extremely rare. Some of the patients are clinically silent, except for cases in which a coronary artery passes between the pulmonary artery and aorta, which can present with sudden death expecially in the athletes. Yet, most of the patient can present with recurrent ischemia or heart failure at younger age. Treatment is still controversial and no guidelines for treatment of this condition exist. We report the case of an octogenarean patient with acute inferior myocardial infarction who was managed by primary percutaneous coronary intervention (PCI) to the single coronary ostium.
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- 2013
25. Correlation between D-dimer levels and coronary artery reperfusion in acute myocardial infarction patients after thrombolytic treatment
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Fatma Ozdemir, Mehmet Akif Cakar, Ceyhun Varim, Huseyin Gunduz, Ramazan Akdemir, Mehmet Bülent Vatan, Cakar, MA, Gunduz, H, Varim, C, Ozdemir, F, Vatan, MB, Akdemir, R, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Çakar, Mehmet Akif, Gündüz, Hüseyin, Varım, Ceyhun, Vatan, Mehmet Bülent, and Akdemir, Ramazan
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Adult ,Male ,medicine.medical_specialty ,Thrombolytic treatment ,Streptokinase ,Myocardial Infarction ,Myocardial Reperfusion ,Fibrin Fibrinogen Degradation Products ,Internal medicine ,D-dimer ,medicine ,Humans ,Thrombolytic Therapy ,In patient ,Myocardial infarction ,Intravenous tissue plasminogen activator ,Symptom onset ,Aged ,Aged, 80 and over ,business.industry ,Hematology ,General Medicine ,Middle Aged ,medicine.disease ,medicine.anatomical_structure ,Tissue Plasminogen Activator ,Acute Disease ,Cardiology ,Female ,business ,Artery ,medicine.drug - Abstract
The correlation between plasma D-dimer level and reperfusion has not been clarified yet in thrombolytic therapy applied for acute myocardial infarction patients. The aim of this study was to investigate whether there is a relationship between reperfusion and fibrinolytic activity in acute myocardial infarction patients treated with thrombolytic therapy. Fibrinolytic activity was reflected by plasma D-dimer levels. During the study period, 186 patients were initially analyzed. But 18 of these patients were excluded from the study because they were not suitable for study criteria. Blood was collected from 168 acute myocardial infarction patients within first 6 h. Intravenous tissue plasminogen activator (100 mg) or streptokinase (1,500,000 U) was applied to patients. Mean age of the patients was 58 (28-86) years and majority was men (86%). The number of anterior, inferior, and lateral myocardial infarction patients were 76 (45.2%), 85 (50.6%), and seven (4.2%), respectively. The mean time from symptom onset to thrombolytic application was 134 (95-212) min. Reperfusion occurred in 115 (68.5%) patients. D-dimer levels were markedly high after thrombolytic therapy versus before (155 mg/dl, 362 mg/dl, P
- Published
- 2013
26. Native aortic coarctation stenting in adults and adolescents: early and mid-term results of an adult interventional cardiology team
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Mehmet Akif Cakar, Sani Namik Murat, Zeydin Acar, Harun Kilic, Huseyin Gunduz, Ramazan Akdemir, Yüksel Kaya, Mehmet Bülent Vatan, Mustafa Tarık Ağaç, Ekrem Yeter, Mehmet Dogan, Ali Fuat Erdem, Akdemir, R, Gunduz, H, Murat, S, Kilic, H, Yeter, E, Agac, MT, Acar, Z, Kaya, Y, Dogan, M, Vatan, MB, Cakar, MA, Erdem, AF, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Akdemir, Ramazan, Gündüz, Hüseyin, Kılıç, Harun, Ağaç, Mustafa Tarık, Doğan, Metin, Vatan, Mehmet Bülent, Çakar, Mehmet Akif, and Erdem, Ali Fuat
- Subjects
medicine.medical_specialty ,Interventional cardiology ,business.industry ,medicine.medical_treatment ,Perforation (oil well) ,Stent ,medicine.disease ,equipment and supplies ,Surgery ,Aneurysm ,Blood pressure ,surgical procedures, operative ,Restenosis ,Internal medicine ,Angioplasty ,medicine.artery ,Cardiology ,cardiovascular system ,Cardiovascular System & Cardiology ,Medicine ,cardiovascular diseases ,Cardiology and Cardiovascular Medicine ,business ,Subclavian artery - Abstract
Background: Stent implantation has evolved as an important therapeutic strategy for aortic coarctation. Aim: This study aimed to present the experience of aortic coarctation stenting using the Cheatham-Platinum stent by an Adult Interventional Cardiology Team. Material and methods: The data of 11 patients (ages were between 15 to 58 years) who underwent aortic coarctation stent implantation between 2008 and 2011 for moderate to severe native aortic coarctation were retrospectively collected. Results: Average systolic blood pressure was 175 ±35 mm Hg, and mean diastolic blood pressure was 115 ±15 mm Hg. Pressure gradient proximal and distal to aortic coarctation was 55.5 ±17.7 before the stenting. The invasive gradient decreased below 10 mm Hg in all patients. There were no complications except in one patient whose subclavian artery was occluded without any clinical finding. One patient had a totally occluded lesion, needing perforation for acquired interruption using a 0.35 inch hydrophilic wire under the supporting balloon. There was no aneurysm or restenosis at follow-up. Left ventricular functions completely recovered within 1 month in all patients. Conclusions: Stenting using the Cheatham-Platinum stent, either covered or bare, is safe in moderate to severe native aortic coarctation and provides an excellent transcoarctation gradient and clinical hypertension and left ventricular functional relief in adult patients.
- Published
- 2012
27. The Effect of Admission Creatinine Levels on One-Year Mortality in Acute Myocardial Infarction
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Mehmet Bülent Vatan, Mehmet Akif Cakar, Ramazan Akdemir, Huseyin Gunduz, Ibrahim Kocayigit, Cakar, MA, Gunduz, H, Vatan, MB, Kocayigit, I, Akdemir, R, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Çakar, Mehmet Akif, Gündüz, Hüseyin, Vatan, Mehmet Bülent, and Akdemir, Ramazan
- Subjects
Male ,medicine.medical_specialty ,Article Subject ,Myocardial Infarction ,lcsh:Medicine ,Gastroenterology ,lcsh:Technology ,General Biochemistry, Genetics and Molecular Biology ,One year mortality ,Coronary artery disease ,chemistry.chemical_compound ,Patient Admission ,Internal medicine ,medicine ,Humans ,In patient ,Myocardial infarction ,Intensive care medicine ,lcsh:Science ,General Environmental Science ,Aged ,Creatinine ,business.industry ,lcsh:T ,Mortality rate ,lcsh:R ,General Medicine ,Middle Aged ,medicine.disease ,Normal group ,Elevated serum creatinine ,chemistry ,Clinical Study ,Science & Technology - Other Topics ,lcsh:Q ,Female ,business - Abstract
Background.We have known that patients with renal insufficiency (creatinine level) have increased mortality for coronary artery disease. In this study, the relationship between admission creatinine level and one year mortality are evaluated in patients with acute myocardial infarction (AMI).Method. 160 AMI patients (127 men and 33 women with a mean age of 59 ± 13) were enrolled in the study. Serum creatinine levels were measured within 12 hours of AMI. The patients were divided into two groups according to admission serum creatinine level. (1) elevated group (serum creatinine > 1.3 mg/dL) and (2) normal group (≤1.3 mg/dL). One year mortality rates were evaluated.Results. Elevated serum creatinine is observed in the 27 patients (16.9%). The mean creatinine level is 1.78 ± 7 mg/dL in the elevated group and 0.9 ± 0.18 mg/dL in the normal group (P<0.0001). The mortality rate of the elevated group (n=7, 25.9%) is higher than that of the normal group (n=9, 6.8%). A significant increase in one year mortality is also observed (P=002) 60.Conclusion. The mildly elevated admission serum creatinine levels are markedly increased to one year mortality in patients with AMI.
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- 2012
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28. Concurrent acute interstitial pneumonia and pulmonary embolism during treatment with peginterferon alpha-2a and ribavirin in a patient with hepatitis C
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Mehmet Yahyaoglu, MBulent Vatan, Hikmet Çoban, Coban, H, Yahyaoglu, M, Vatan, MB, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, and Vatan, Mehmet Bülent
- Subjects
medicine.medical_specialty ,pulmonary embolism ,Drug Watch ,Gastroenterology ,Polyethylene Glycols ,chemistry.chemical_compound ,Combined treatment ,Internal medicine ,Ribavirin ,medicine ,Humans ,Pharmacology (medical) ,Interstitial pneumonia ,peginterferon ,Pharmacology & Pharmacy ,Pharmacology ,business.industry ,Interferon-alpha ,virus diseases ,Peginterferon alpha-2a ,Hepatitis C ,Middle Aged ,medicine.disease ,Recombinant Proteins ,digestive system diseases ,Pulmonary embolism ,ribavarin ,Treatment Outcome ,chemistry ,Acute Disease ,Acute Interstitial Pneumonia ,Lung Diseases, Interstitial ,business - Abstract
The case presented is the first patient with concurrent acute interstitial pneumonia and pulmonary embolism associated with combined treatment of peginterferon and ribavirin for hepatitis C.
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- 2014
29. The effect of the systemic immune-inflammatory index on the no-reflow phenomenon in patients undergoing saphenous vein intervention.
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Cakmak AC, Kocayigit İ, Varım P, Çakmak BS, Can Y, and Vatan MB
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Introduction: The systemic immune inflammation index (SII), based on lymphocyte, neutrophil, and platelet counts, has been shown to be an independent indicator of no-reflow phenomenon during percutaneous intervention. However, the relationship between SII and no-reflow phenomenon (NRP) that develops after the procedure of saphenous vein grafts is unknown., Aim: In this study, we aimed to investigate the relationship between no-reflow phenomenon and SII during percutaneous intervention on saphenous vein grafts., Material and Methods: A total of 133 patients who underwent percutaneous intervention for saphenous vein grafts due to acute coronary syndrome between 2019 and 2022 were included in this study. The receiver-operating characteristics (ROC) curve was used to determine the cut-off value of SII to predict the no-reflow. The multivariate regression was used to analyse the correlation between no-reflow and SII., Results: The median value of SII was significantly higher in patients with no-reflow in comparison with normal reperfusion (543 (447, 717) vs. 861 (642, 1272), p < 0.001). The optimal threshold for SII in predicting the no-reflow phenomenon was 613, with sensitivity and specificity of 84% and 66%, respectively. The area under the ROC curve (AUC) was 0.80 (95% CI: 0.73-0.89, p < 0.001). In multivariate analysis, SII ≥ 613 showed an independent predictive value for the no-reflow (OR = 4.02, 95% CI: 1.40-11.57, p < 0.001)., Conclusions: Our results showed that high SII levels were independently associated with the development of no-reflow phenomenon in patients presenting with acute coronary syndrome and undergoing percutaneous intervention to the SVG., Competing Interests: The authors declare no conflict of interest., (Copyright: © 2024 Termedia Sp. z o. o.)
- Published
- 2024
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30. Reply to Letter to the Editor: 'A Modified Medina and Movahed (3M) Classification of Coronary Bifurcation Lesions''.
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Ağaç MT, Vatan MB, Çakar MA, and Tatlı E
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- 2024
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31. Reply to Letter to the Editor: 'The Movahed Coronary Bifurcation Lesion Classification Introduces Limitless Optional Suffixes That Can Easily be Used for Clinical Use or Coding Purposes'.
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Ağaç MT, Vatan MB, Çakar MA, and Tatlı E
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- Humans, Heart, Coronary Artery Disease diagnostic imaging, Coronary Artery Disease surgery, Angioplasty, Balloon, Coronary
- Published
- 2023
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32. Efficacy of Transpedal Retrograde Approach in Endovascular Treatment of Patients With Buerger's Disease.
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Tatli E, Buturak A, Vatan MB, Kurt Ömürlü I, and Erkin A
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- Humans, Ulcer, Treatment Outcome, Amputation, Surgical, Pain, Ischemia diagnosis, Ischemia etiology, Ischemia surgery, Limb Salvage, Thromboangiitis Obliterans complications, Thromboangiitis Obliterans diagnosis, Thromboangiitis Obliterans surgery
- Abstract
Background: Endovascular treatment of Buerger's disease is challenging, which usually impedes antegrade revascularization options. We aimed to evaluate the effectiveness of transpedal retrograde approach in patients with Buerger's disease with ambiguous proximal caps and/or previously failed endovascular intervention via antegrade approach., Methods: Eighteen patients with the diagnosis of Buerger's disease who had previously failed antegrade endovascular interventions and/or ambiguous proximal caps were enrolled. Baseline demographic characteristics, severity of critical limb-threatening ischemia, wound scores, postprocedural pedal loop scores, and recovery or amputation rates were recorded., Results: The patients presented with ischemic rest pain (n = 5, Rutherford stage 4), ischemic ulcers with minor tissue loss (n = 8, Rutherford stage 5), and severe ischemic ulcers or gangrene with major tissue loss (n = 5, Rutherford stage 6). Preprocedural wound score according to Saint Elian Wound Score System (SEWSS) was 15.72 ± 5.05. Retrograde transpedal puncture was achieved with an 89% success rate. Postintervention angiographic success rate was 100%. Postintervention Rutherford stage improved compared with preprocedural Rutherford stages (P<.01). In addition, the average SEWSS score decreased significantly after the interventions (P<.001). Postprocedural pedal loop score was found to be associated with SEWSS scores and amputation rates., Conclusions: Transpedal retrograde approach is a technically feasible and potentially effective treatment modality for Buerger's disease and may be considered as a first-line treatment option in the treatment of limb salvage, especially when proximal caps of target vessels are ambiguous or antegrade approach is unsuccessful.
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- 2023
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33. A Novel Descriptive Coding System for Coronary Bifurcation Lesions.
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Ağaç MT, Vatan MB, Çakar MA, and Tatlı E
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- Humans, Heart, Coronary Angiography, Treatment Outcome, Coronary Artery Disease diagnostic imaging, Coronary Artery Disease pathology, Coronary Stenosis diagnostic imaging, Percutaneous Coronary Intervention
- Published
- 2023
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34. Effects of statin response on cardiovascular outcomes in patients with ST-segment elevation myocardial infarction.
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Vatan MB, Varım P, Ağaç S, Erkan H, and Coşansu K
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- Cholesterol, LDL, Humans, Incidence, Risk Factors, Treatment Outcome, Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use, ST Elevation Myocardial Infarction drug therapy
- Abstract
Objective: This study aimed to evaluate the effects of statin response on cardiovascular outcomes in patients with ST-segment elevation myocardial infarction., Methods: A total of 1029 ST-segment elevation myocardial infarction patients were enrolled in the study. The patients who failed to achieve >40% reduction in baseline low-density lipoprotein cholesterol levels within 30 days to 12 months after statin initiation were defined as suboptimal statin responders. The adjusted hazard ratios for cardiovascular outcomes for low-density lipoprotein cholesterol response to statins were estimated via the Cox proportional regression model. The relationship between the statin response and cardiovascular outcomes was also evaluated in a subgroup of on-treatment low-density lipoprotein cholesterol levels below 55 mg/dL., Results: Among the study population, 573 (55.6%) patients demonstrated suboptimal low-density lipoprotein cholesterol response to statin therapy. These patients showed a significantly higher incidence of the composite of major adverse cardiovascular events, including cardiovascular death, reinfarction, recurrent myocardial infarction, and target vessel revascularization during the follow-up compared with optimal responders (adjusted hazard ratios 3.99; 95%CI 2.66-6.01; p<0.001). In a subgroup of patients with on-treatment low-density lipoprotein cholesterol levels below 55 mg/dL, suboptimal statin responders also showed unfavorable cardiovascular outcomes (adjusted hazard ratios 8.73; 95%CI 2.81-27.1; p<0.001)., Conclusions: The present study showed that over half of the patients with ST-segment elevation myocardial infarction did not exhibit optimal low-density lipoprotein cholesterol response to statin. These patients have an increased risk of future major adverse cardiovascular events.
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- 2022
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35. A Novel Closed-Loop Balloon-Stent Technique for Vessel Closure.
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Ağaç MT, Vatan MB, and Tatlı E
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- Humans, Treatment Outcome, Angioplasty, Balloon, Coronary adverse effects, Stents
- Abstract
Competing Interests: Funding Support and Author Disclosures The authors have reported that they have no relationships relevant to the contents of this paper to disclose.
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- 2022
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36. Is endocan a biochemical marker for asymptomatic target organ damage in hypertensive patients?
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Ağaç MT, Kahyaoğlu B, Aksoy MMN, Cinemre FB, Vatan MB, and Gündüz Y
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- Biomarkers blood, Blood Pressure, Cardiovascular Diseases pathology, Carotid Intima-Media Thickness, Female, Glomerular Filtration Rate, Humans, Hypertension pathology, Kidney Diseases pathology, Male, Middle Aged, Cardiovascular Diseases physiopathology, Hypertension blood, Kidney Diseases physiopathology, Neoplasm Proteins blood, Proteoglycans blood
- Abstract
Objective: Identification of the asymptomatic target organ damage (AOD) helps to stratify the overall risk of cardiovascular (CV) diseases and guides a treatment decision in hypertensive patients without a symptomatic CV or renal disease. The endothelial-cell-specific molecule 1 (endocan) is regarded as a novel marker of endothelial dysfunction. Its release is increased in hypertensive patients, especially those with symptomatic CV and renal disease. In the present study, we aimed to evaluate the endocan levels in asymptomatic hypertensive patients with or without AOD., Methods: The study included 132 asymptomatic hypertensive patients, and 101 of who had at least one AOD., Results: Serum endocan levels did not differ between patients with and without AOD (3.81±0.78 vs. 3.83±0.63 ng/mL, p=0.88). An analysis according to the presence of any specific AOD did not show any difference between groups. No significant correlation was found between serum endocan levels and any of the continuous variables related to AOD, such as the pulse pressure, carotid intimae-media thickness, cardio-ankle vascular index, ankle-brachial index, left ventricular mass index, Sokolow-Lyon index, Cornell voltage-duration product, and estimated glomerular filtration rate., Conclusion: Endocan may not serve as a useful biomarker at asymptomatic vascular stages of hypertension, despite its role in indicating disease severity and inflammatory activation in advanced symptomatic CV and renal disease.
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- 2019
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37. Impact of direct stenting on clinical outcomes for small vessel coronary artery disease in patients undergoing primary percutaneous coronary intervention for ST-elevation myocardial infarction.
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Cosansu K, Ureyen CM, Vatan MB, Agac MT, Kilic H, and Akdemir R
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Introduction: Direct stenting (DS) is associated with improved markers of reperfusion during primary percutaneous coronary intervention (PPCI) for ST-elevation myocardial infarction (STEMI). However, data evaluating its impact in small vessel coronary artery disease (CAD) are lacking., Aim: To compare DS and conventional stenting (CS) for small vessel CAD on clinical outcomes of patients with STEMI undergoing PPCI., Material and Methods: A cohort of 616 STEMI patients treated with DS (202 patients) or CS (414 patients) in small vessel (≤ 2.75 mm) lesions was retrospectively analyzed. The primary endpoint was to compare the occurrence of major adverse cardiac events (MACE) between groups during 2-year follow-up. The secondary end points included in-hospital target lesion revascularization (TLR) and in-hospital death., Results: The primary end-point, MACEs, occurred in 9.2% in the DS group and 12.3% in the CS group ( p > 0.05). The rates of TLR, myocardial infarction (MI) and target vessel revascularization (TVR) were not significantly different between groups ( p > 0.05). The stent thrombosis (ST) rate was significantly lower in the DS group (1.0% vs. 4.2%, p = 0.04) at 2 years. However, DS was not found to be an independent predictor of ST in multivariate analysis. There were no significant differences in in-hospital rates of death and TLR. The DS compared to CS resulted in greater rates of postprocedural TIMI grade 3 flow, and lower risk of edge dissection. The procedure time, radiation exposure and contrast administration were found to be significantly lower in the DS group., Conclusions: In selected patients with STEMI undergoing PPCI for small vessel CAD, DS is not only safe and feasible but also reduces ST rates, contrast load, and procedural and radiation exposure time., Competing Interests: The authors declare no conflict of interest., (Copyright: © 2019 Termedia Sp. z o. o.)
- Published
- 2019
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38. Use of neutrophil-lymphocyte ratio for risk stratification and relationship with time in therapeutic range in patients with nonvalvular atrial fibrillation: A pilot study.
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Cosansu K, Vatan MB, Gunduz H, and Akdemir R
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- Aged, Atrial Fibrillation blood, Atrial Fibrillation epidemiology, Female, Follow-Up Studies, Humans, Incidence, Leukocyte Count, Lymphocytes, Male, Neutrophils, Pilot Projects, Retrospective Studies, Severity of Illness Index, Thromboembolism blood, Thromboembolism etiology, Turkey epidemiology, Anticoagulants therapeutic use, Atrial Fibrillation complications, Risk Assessment, Thromboembolism prevention & control
- Abstract
Background: Atrial fibrillation is one of the most common abnormal heart rhythms. Neutrophil-lymphocyte ratio (NLR) has emerged as a potential marker for the level of inflammation in cardiac disorders., Hypothesis: NLR might be associated with thrombosis and bleeding risk scores and might predict cardioembolic risk in nonvalvular atrial fibrillation (NVAF) patients within the therapeutic international normalized ratio (INR)., Methods: We enrolled 272 patients taking warfarin for NVAF and classified them into 2 groups: Group A consisted of patients (n = 132) whose time in therapeutic range (TTR) was ≥65%, and Group B comprised patients (n = 139) whose TTR was <65%., Results: NLR values were higher in group B than in group A (P < 0.0001). Patients classified as high risk according to CHA
2 DS2 -VASc score had significantly higher NLR levels (P = 0.002) than those classified as low and intermediate risk. Furthermore, NLR levels were significantly correlated with CHA2 DS2 -VASc and HAS-BLED scores (P < 0.001 and P < 0.0001, respectively). NLR predicted patients within therapeutic INR range (TTR ≥65%) with sensitivity of 81% and specificity of 71% in a receiver operator characteristic curve analysis, using a cutoff value of 2.17. Area under the curve for NLR was 0.81 (P < 0.0001)., Conclusions: To our knowledge, this is the first study showing correlation of NLR with both CHA2 DS2 -VASc and HAS-BLED risk scores. NLR might represent a useful marker to identify patients with high risks of stroke and bleeding and may have predictive value in identifying patients within the therapeutic INR range., (© 2018 Wiley Periodicals, Inc.)- Published
- 2018
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39. [Updates in 2017 ESC Guidelines on the Diagnosis and Treatment of Peripheral Arterial Diseases].
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Akdemir R and Vatan MB
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- Cardiology organization & administration, Cardiology standards, Europe, Humans, Practice Guidelines as Topic, Risk Factors, Societies, Medical, Peripheral Arterial Disease diagnosis, Peripheral Arterial Disease therapy
- Published
- 2017
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40. Left ventricular twist was decreased in isolated left bundle branch block with preserved ejection fraction.
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Yılmaz S, Kılıc H, Ağac MT, Keser N, Edem E, Demirtaş S, Vatan MB, Akdemir R, and Gündüz H
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- Aged, Bundle-Branch Block diagnostic imaging, Case-Control Studies, Cross-Sectional Studies, Echocardiography, Female, Humans, Logistic Models, Male, Middle Aged, Rotation, Stroke Volume, Systole, Ventricular Dysfunction, Left diagnostic imaging, Bundle-Branch Block physiopathology, Ventricular Dysfunction, Left physiopathology
- Abstract
Objective: Left ventricular (LV) rotation and twist play an important role in LV contraction and relaxation. Left bundle branch block (LBBB) deteriorates both diastolic and systolic functions. We evaluated the LV twist in patients with LBBB and preserved ejection fraction (EF) (>50%) to determine twist as a potential marker for subtle myocardial dysfunction., Methods: This observational cross-sectional study included 34 LBBB patients with preserved EF who were free from ischemic and valvular disease (Group 1) and 36 healthy controls (Group 2). All patients underwent 2-D Doppler and 2-D speckle tracking echocardiography. LV apical, basal rotation, and twist were evaluated in both groups and compared accordingly. In addition, subjects were dichotomized considering the median twist value of the study population. Binary logistic regression analysis was performed to determine the independent variables associated with inframedian twist., Results: Baseline clinical characteristics were similar in LBBB patients and controls. Mean apical rotation (2.5°±1.9° vs. 4.4°±2.9°; p=0.002), basal rotation (-2.9°±2.3° vs. -4.1°±2.7°; p=0.05), and twist (5.4°±3° vs. 8.6°±3.3°; p<0.001) were decreased in group 1. Parameters related to intra- and interventricular mechanical dyssynchrony, such as longitudinal left ventricular dyssynchrony index (LVdys) and preejection interval of LV, interventricular mechanical delay (IVMD), and left posterior wall contractions (SPMWD) were significantly higher in the LBBB group. The median twist value of the studied population was 6.65°. Binary logistic regression analysis showed that only presence of LBBB was independently associated with inframedian twist (OR=6.250; 95% CI: 2.215-17.632; p<0.001)., Conclusion: The LBBB might have induced the reduction of LV twist by diminishing the LV rotation before inducing a prominent effect on the left ventricular ejection fraction (LVEF). Therefore, twist may be considered as a marker for subtle LV dysfunction in LBBB with substantially normal EF.
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- 2017
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41. Does Vitamin D Deficiency Effect Heart Rate Variability in Low Cardiovascular Risk Population?
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Nalbant A, Vatan MB, Varım P, Varım C, Kaya T, and Tamer A
- Abstract
Aim: This study aimed to evaluate the cardiac autonomic dysfunction and the cardiac arrhythmia risk using heart rate variability parameters in subjects with vitamin D deficiency and low cardiovascular risk., Material and Methods: One hundred five consecutive individuals, 54 patients with low vitamin D status and 51 healthy controls were enrolled in this study. The overall cardiac autonomic tone was quantified by using various heart rate variability parameters included mean RR interval, mean Heart Rate, mean of standard deviations of intervals for 24 hours (SDNN), standard deviation of averages of intervals (SDANN), mean of standard deviation of intervals for 5 minutes (SDNNI), root mean square of difference of successive intervals (rMSSD) and the proportion of intervals differing more than 50 ms (pNN50) values. The 12-lead ECG was recorded from each participant, and QT intervals were measured., Results: Baseline demographic profiles were similar between two groups. The heart rate variability parameters such as mean RR interval, mean HR, SDNN, SDANN, SDNNI, rMSSD and pNN50 (%) values were not significantly different in patients with low vitamin D status compared to control group. The electrocardiography analysis revealed only slight but significant prolongation of corrected QT (QTc) intervals in the control group., Conclusion: HRV variables were not significantly altered in patients with vitamin D deficiency in low cardiovascular risk profile group. Further studies evaluating these findings in other cohorts with high cardiovascular risk are required.
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- 2017
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42. Comparison of closed-cell and hybrid-cell stent designs in carotid artery stenting: clinical and procedural outcomes.
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Tatli E, Tokatli A, Vatan MB, Agac MT, Gunduz H, Akdemir R, and Kilic H
- Abstract
Introduction: Carotid artery stenting (CAS) is a promising alternative to surgery in high-risk patients. However, the impact of stent cell design on outcomes in CAS is a matter of continued debate., Aim: To compare the periprocedural and clinical outcomes of different stent designs for CAS with distal protection devices., Material and Methods: All CAS procedures with both closed- and hybrid-cell stents performed at our institution between February 2010 and December 2015 were analyzed retrospectively. Adverse events were defined as death, major stroke, minor stroke, transient ischemic attack and myocardial infarction. Periprocedural and 30-day adverse events and internal carotid artery (ICA) vasospasm rates were compared between the closed-cell and hybrid-cell stent groups., Results: The study included 234 patients comprising 146 patients with a closed-cell stent (Xact stent, Abbott Vascular) (mean age: 68.5 ±8.6; 67.1% male) and 88 patients with a hybrid-cell stent (Cristallo Ideale, Medtronic) (mean age: 67.2 ±12.8; 68.2% male). There was no significant difference between the groups with respect to periprocedural or 30-day adverse event rates. While there was no difference in terms of tortuosity index between the groups, there was a higher procedural ICA vasospasm rate in the closed-cell stent group (35 patients, 23%) compared with the hybrid-cell stent group (10 patients, 11%) ( p = 0.017)., Conclusions: The results of this study showed no significant difference in the clinical adverse event rates after CAS between the closed-cell stent group and the hybrid-cell stent group. However, procedural ICA vasospasm was more common in the closed-cell stent group.
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- 2017
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43. ECG Changes Due to Hypothermia Developed After Drowning: Case Report.
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Yilmaz S, Cakar MA, Vatan MB, Kilic H, and Keser N
- Abstract
Drowning is one of the fatal accidents frequently encountered during the summer and is the most common cause of accidental death in the world. Anoxia, hypothermia, and metabolic acidosis are mainly responsible for morbidty. Cardiovascular effects may occur secondary to hypoxia and hypothermia. Atrial fibrillation, sinus dysrhythmias (rarely requiring treatment), and, in serious cases, ventricular fibrillation or asystole may develop, showing as rhythm problems on electrocardiogram and Osborn wave can be seen, especially during hypothermia. A 16-year-old male patient who was admitted to our hospital's emergency service with drowning is presented in this article. In our case, ventricular fibrillation and giant J wave (Osborn wave) associated with hypothermia developed after drowning was seen. We present this case as a reminder of ECG changes due to hypothermia that develop after drowning. Response to cardiopulmonary resuscitation after drowning and hypothermia is not very good. Mortality is very high, so early resuscitation and aggressive treatment of cardiovascular and respiratory problems are important for life.
- Published
- 2016
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44. Usefulness of the platelet-to-lymphocyte ratio in predicting the severity of carotid artery stenosis in patients undergoing carotid angiography.
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Varım C, Varım P, Acar BA, Vatan MB, Uyanık MS, Kaya T, Acar T, and Akdemir R
- Subjects
- Aged, Angiography, Carotid Arteries diagnostic imaging, Carotid Stenosis diagnostic imaging, Carotid Stenosis pathology, Female, Humans, Lymphocyte Count, Male, Middle Aged, Platelet Count, ROC Curve, Severity of Illness Index, Carotid Stenosis blood
- Abstract
Carotid artery stenosis (CAS) is primarily caused by atherosclerotic plaque. Progressive inflammation may contribute to the rupture of an atherosclerotic plaque. The platelet-to-lymphocyte ratio (PLR) is a new and simple marker that indicates inflammation. In this study, we aimed to investigate the use of the PLR to determine the severity of CAS. One hundred forty patients were chosen from among patients who underwent carotid angiography in our institution. Symptomatic patients with stenosis >50% in the carotid arteries and asymptomatic patients with stenosis >80% were diagnosed via carotid angiography as having critical stenosis. Patients were classified into two groups. Group 1 included patients who had critical CAS, whereas Group 2 included patients with noncritical CAS, as determined by carotid angiography. Correlations between the PLR and the severity of CAS were analyzed. There were no significant differences in sex and age between the two groups. The PLR was 162.5 ± 84.7 in the noncritical CAS group patients and 94.9 ± 60.3 in the critical CAS group patients (p < 0.0001). The PLR value of 117.1 had 89% sensitivity and 68% specificity for CAS [95% confidence interval, 0.043-0.159; area under the curve, 0.101 ± 0.03)]. In this study, we have shown that PLR values may be associated with critical stenosis in at least one of the carotid arteries. Furthermore, PLR values may be used to predict critical stenosis in the carotid arteries., (Copyright © 2016. Published by Elsevier Taiwan.)
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- 2016
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45. Echocardiographic Evaluation of Biventricular Function in Patients with Euthyroid Hashimoto's Thyroiditis.
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Vatan MB, Varım C, Ağaç MT, Varım P, Çakar MA, Aksoy M, Erkan H, Yılmaz S, Kilic H, Gündüz H, and Akdemir R
- Subjects
- Female, Hashimoto Disease pathology, Heart Ventricles pathology, Humans, Male, Middle Aged, Tricuspid Valve pathology, Ventricular Function, Left, Echocardiography, Doppler methods, Hashimoto Disease diagnostic imaging, Heart Ventricles diagnostic imaging, Tricuspid Valve diagnostic imaging, Ventricular Dysfunction diagnostic imaging
- Abstract
Objective: The aim of this study was to evaluate the left (LV) and right (RV) ventricular function in euthyroid Hashimoto's thyroiditis (eHT) patients., Subjects and Methods: Forty-five patients diagnosed with eHT and 45 age- and gender-matched control subjects were enrolled in this study. Echocardiographic parameters reflecting RV and LV functions such as chamber dimensions, ejection fraction, fractional shortening, conventional and tissue Doppler-derived early and late filling velocities (E, A, E', A'), isovolumic relaxation (IVRT) and contraction (IVCT) times, ejection time (ET), deceleration time (DT), Tei index, pulmonary acceleration time (PAcT) and tricuspid annular plane systolic excursion (TAPSE) of patients with eHT were compared to those of control subjects using the paired-samples t test or Wilcoxon signed-rank test., Results: Regarding the LV function, compared to the controls patients with eHT had a higher LV-Tei index (0.6 ± 0.2 vs. 0.4 ± 0.1, p < 0.001), higher DT (p < 0.001) and IVRT (p < 0.001) values, and higher E/E' ratios (p = 0.04). In contrast, the peak E wave velocity (p = 0.02), E/A ratio (p = 0.01) and ET (p = 0.02) were significantly lower in the eHT group than amongst the controls. The RV, Tei index (0.40 ± 0.11 vs. 0.28 ± 0.07, p < 0.001), TAPSE (2.0 ± 0.3 vs. 2.2 ± 0.2 mm, p < 0.001), PAcT (124.3 ± 22.6 vs. 149.4 ± 18.3 ms, p < 0.001), A' (p = 0.007) and IVCT (p = 0.001) were significantly higher in patients with eHT than the controls. However, the tricuspid E/A ratio (p = 0.01), E' (p = 0.03) and E'/A' ratio (p = 0.001) were significantly lower in the eHT patients than the control group., Conclusions: This study demonstrated that both RV and LV functions were impaired in patients with eHT., (© 2015 S. Karger AG, Basel.)
- Published
- 2016
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46. Relationship between CHA2DS2-VASc score and atrial electromechanical function in patients with paroxysmal atrial fibrillation: A pilot study.
- Author
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Vatan MB, Yılmaz S, Ağaç MT, Çakar MA, Erkan H, Aksoy M, Demirtas S, Varım C, Akdemir R, and Gündüz H
- Subjects
- Adult, Aged, Atrial Fibrillation complications, Atrial Remodeling, Echocardiography, Female, Humans, Male, Middle Aged, Pilot Projects, ROC Curve, Risk Assessment methods, Atrial Fibrillation physiopathology, Atrial Function, Left physiology, Severity of Illness Index, Stroke etiology
- Abstract
Background: CHA2DS2-VASc score is the most widely preferred method for prediction of stroke risk in patients with atrial fibrillation. We hypothesized that CHA2DS2-VASc score may represent atrial remodeling status, and therefore echocardiographic evaluation of left atrial electromechanical remodeling can be used to identify patients with high risk., Methods: A total of 65 patients who had documented diagnosis of paroxysmal atrial fibrillation (PAF) were divided into three risk groups according to the CHA2DS2-VASc score: patients with low risk (score=0, group 1), with moderate risk (score=1, group 2), and with high risk score (score ≥2, group 3). We compared groups according to atrial electromechanical intervals and left atrium mechanical functions., Results: Atrial electromechanical intervals including inter-atrial and intra-atrial electromechanical delay were not different between groups. However, parameters reflecting atrial mechanical functions including LA phasic volumes (Vmax, Vmin and Vp) were significantly higher in groups 2 and 3 compared with group 1. Likewise, LA passive emptying volume (LATEV) in the groups 2 and 3 was significantly higher than low-risk group (14.12±8.13ml/m(2), 22.36±8.78ml/m(2), 22.89±7.23ml/m(2), p: 0.031). Univariate analysis demonstrated that Vmax, Vmin and Vp were significantly correlated with CHA2DS2-VASc score (r=0.428, r=0.456, r=0.451 and p<0.001). Also, LATEV (r=0.397, p=0.016) and LA active emptying volume (LAAEV) (r=0.281, p=0.023) were positively correlated with CHA2DS2-VASc score. In the ROC analysis, Vmin≥11ml/m(2) has the highest predictive value for CHA2DS2-VASc score ≥2 (88% sensitivity and 89% specificity; ROC area 0.88, p<0.001, CI [0.76-0.99])., Conclusion: Echocardiographic evaluation of left atrial electromechanical function might represent a useful method to identify patients with high risk., (Copyright © 2015 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2015
- Full Text
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47. Acute myocardial infarction due to simultaneous occlusions of the left anterior descending artery and right coronary artery.
- Author
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Edem E, Varım P, Pabuccu MT, and Vatan MB
- Subjects
- Coronary Angiography, Coronary Occlusion diagnostic imaging, Coronary Occlusion therapy, Electrocardiography, Humans, Male, Middle Aged, Myocardial Infarction diagnostic imaging, Myocardial Infarction therapy, Stents, Coronary Occlusion complications, Myocardial Infarction complications
- Published
- 2015
- Full Text
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48. A novel treatment approach for common carotid artery bifurcation aneurysms.
- Author
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Edem E, Tatli E, Vatan MB, Demirtaş S, Cakar MA, and Kilic H
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- 2015
- Full Text
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49. DNA Repair Gene Polymorphism and the Risk of Mitral Chordae Tendineae Rupture.
- Author
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Yigin AK, Vatan MB, Akdemir R, Aksoy MN, Cakar MA, Kilic H, Erkorkmaz U, Karacan K, and Kaleli S
- Subjects
- Adult, Aged, Case-Control Studies, Female, Heart Valve Diseases pathology, Heterozygote, Humans, Male, Middle Aged, Chordae Tendineae pathology, DNA-Binding Proteins genetics, Heart Valve Diseases genetics, Mitral Valve pathology, Polymorphism, Single Nucleotide
- Abstract
Polymorphisms in Lys939Gln XPC gene may diminish DNA repair capacity, eventually increasing the risk of carcinogenesis. The aim of the present study was to evaluate the significance of polymorphism Lys939Gln in XPC gene in patients with mitral chordae tendinea rupture (MCTR). Twenty-one patients with MCTR and thirty-seven age and sex matched controls were enrolled in the study. Genotyping of XPC gene Lys939Gln polymorphism was carried out using polymerase chain reaction- (PCR-) restriction fragment length polymorphism (RFLP). The frequencies of the heterozygote genotype (Lys/Gln-AC) and homozygote genotype (Gln/Gln-CC) were significantly different in MCTR as compared to control group, respectively (52.4% versus 43.2%, p = 0.049; 38.15% versus 16.2%, p = 0.018). Homozygote variant (Gln/Gln) genotype was significantly associated with increased risk of MCTR (OR = 2.059; 95% CI: 1.097-3.863; p = 0.018). Heterozygote variant (Lys/Gln) genotype was also highly significantly associated with increased risk of MCTR (OR = 1.489; 95% CI: 1.041-2.129; p = 0.049). The variant allele C was found to be significantly associated with MCTR (OR = 1.481; 95% CI: 1.101-1.992; p = 0.011). This study has demonstrated the association of XPC gene Lys939Gln polymorphism with MCTR, which is significantly associated with increased risk of MCTR.
- Published
- 2015
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50. Concurrent acute interstitial pneumonia and pulmonary embolism during treatment with peginterferon alpha-2a and ribavirin in a patient with hepatitis C.
- Author
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Coban H, Yahyaoglu M, and Vatan MB
- Subjects
- Acute Disease, Hepatitis C complications, Humans, Interferon-alpha administration & dosage, Interferon-alpha therapeutic use, Lung Diseases, Interstitial complications, Lung Diseases, Interstitial diagnosis, Lung Diseases, Interstitial drug therapy, Middle Aged, Polyethylene Glycols administration & dosage, Polyethylene Glycols therapeutic use, Pulmonary Embolism complications, Pulmonary Embolism diagnosis, Pulmonary Embolism drug therapy, Recombinant Proteins administration & dosage, Recombinant Proteins adverse effects, Recombinant Proteins therapeutic use, Ribavirin administration & dosage, Ribavirin therapeutic use, Treatment Outcome, Hepatitis C drug therapy, Interferon-alpha adverse effects, Lung Diseases, Interstitial chemically induced, Polyethylene Glycols adverse effects, Pulmonary Embolism chemically induced, Ribavirin adverse effects
- Abstract
The case presented is the first patient with concurrent acute interstitial pneumonia and pulmonary embolism associated with combined treatment of peginterferon and ribavirin for hepatitis C.
- Published
- 2014
- Full Text
- View/download PDF
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