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1. Quantum simulation of thermodynamics in an integrated quantum photonic processor

Author

Somhorst, F. H. B., van der Meer, R., Anguita, M. Correa, Schadow, R., Snijders, H. J., de Goede, M., Kassenberg, B., Venderbosch, P., Taballione, C., Epping, J. P., Vlekkert, H. H. van den, Timmerhuis, J., Bulmer, J. F. F., Lugani, J., Walmsley, I. A., Pinkse, P. W. H., Eisert, J., Walk, N., and Renema, J. J.

Subjects
Quantum Physics, Condensed Matter - Statistical Mechanics, Physics - Optics
Abstract

One of the core questions of quantum physics is how to reconcile the unitary evolution of quantum states, which is information-preserving and time-reversible, with evolution following the second law of thermodynamics, which, in general, is neither. The resolution to this paradox is to recognize that global unitary evolution of a multi-partite quantum state causes the state of local subsystems to evolve towards maximum-entropy states. In this work, we experimentally demonstrate this effect in linear quantum optics by simultaneously showing the convergence of local quantum states to a generalized Gibbs ensemble constituting a maximum-entropy state under precisely controlled conditions, while introducing an efficient certification method to demonstrate that the state retains global purity. Our quantum states are manipulated by a programmable integrated quantum photonic processor, which simulates arbitrary non-interacting Hamiltonians, demonstrating the universality of this phenomenon. Our results show the potential of photonic devices for quantum simulations involving non-Gaussian states., Comment: 9+12 pages, 12 figures, replaced with final version

Published
2021
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2. Boson Sampling in Low-depth Optical Systems

Author

van der Meer, R., Huber, S., Pinkse, P. W. H., García-Patrón, R., and Renema, J. J.

Subjects
Quantum Physics
Abstract

Optical losses are the main obstacle to demonstrating a quantum advantage via boson sampling without leaving open the possibility of classical spoofing. We propose a method for generating low-depth optical circuits suitable for boson sampling with very high efficiencies. Our circuits require only a constant number of optical components (namely three) to implement an optical transformation suitable for demonstrating a quantum advantage. Consequently, our proposal has a constant optical loss regardless of the number of optical modes. We argue that sampling from our family of circuits is computationally hard by providing numerical evidence that our family of circuits converges to that of the original boson sampling proposal in the limit of large optical systems. Our work opens a new route to demonstrate an optical quantum advantage., Comment: 11 pages, 6 figures

Published
2021

3. Optimizing spontaneous parametric down-conversion sources for boson sampling

Author

van der Meer, R., Renema, J. J., Brecht, B., Silberhorn, C., and Pinkse, P. W. H.

Subjects
Quantum Physics
Abstract

An important step for photonic quantum technologies is the demonstration of a quantum advantage through boson sampling. In order to prevent classical simulability of boson sampling, the photons need to be almost perfectly identical and almost without losses. These two requirements are connected through spectral filtering, improving one leads to a decrease of the other. A proven method of generating single photons is spontaneous parametric downconversion (SPDC). We show that an optimal trade-off between indistinguishability and losses can always be found for SPDC. We conclude that a 50-photon scattershot boson-sampling experiment using SPDC sources is possible from a computational complexity point of view. To this end, we numerically optimize SPDC sources under the regime of weak pumping and with a single spatial mode.

Published
2020
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4. Spatially encoded light for Large-alphabet Quantum Key Distribution

Author

Tentrup, T. B. H., Luiten, W. M., van der Meer, R., Hooijschuur, P., and Pinkse, P. W. H.

Subjects
Quantum Physics
Abstract

Most Quantum Key Distribution protocols use a two-dimensional basis such as HV polarization as first proposed by Bennett and Brassard in 1984. These protocols are consequently limited to a key generation density of 1 bit per photon. We increase this key density by encoding information in the transverse spatial displacement of the used photons. Employing this higher-dimensional Hilbert space together with modern single-photon-detecting cameras, we demonstrate a proof-of-principle large-alphabet Quantum Key Distribution experiment with 1024 symbols and a shared information between sender and receiver of 7 bit per photon., Comment: 9 pages, 6 figures, Added references, Updated Fig. 1 in the main text, Updated Fig.1 in supplementary material, Added section Trojan-horse attacks in supplementary material, title changed, Added paragraphs about final key rate and overfilling the detector to result section

Published
2018
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9. Coherent Cerenkov radiation and laser oscillation in a photonic crystal

Author

Denis, T., van Dijk, M. V., Lee, J. H. H., van der Meer, R., Strooisma, A., van der Slot, P. J. M., Vos, W. L., and Boller, K. J.

Subjects
Physics - Optics
Abstract

We demonstrate that photonic crystals can be used to generate powerful and highly coherent laser radiation when injecting a beam of free electrons. Using theoretical investigations we present the startup dynamics and coherence properties of such laser, in which gain is provided by matching the optical phase velocity in the photonic crystal to the velocity of the electron beam., Comment: 6 pages, 5 figures

Published
2016
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10. Separated Response Functions in Exclusive, Forward $\pi^{\pm}$ Electroproduction on Deuterium

Author

Huber, G. M., Blok, H. P., Butuceanu, C., Gaskell, D., Horn, T., Mack, D. J., Abbott, D., Aniol, K., Anklin, H., Armstrong, C., Arrington, J., Assamagan, K., Avery, S., Baker, O. K., Barrett, B., Beise, E. J., Bochna, C., Boeglin, W., Brash, E. J., Breuer, H., Chang, C. C., Chant, N., Christy, M. E., Dunne, J., Eden, T., Ent, R., Fenker, H., Gibson, E. F., Gilman, R., Gustafsson, K., Hinton, W., Holt, R. J., Jackson, H., Jin, S., Jones, M. K., Keppel, C. E., Kim, P. H., Kim, W., King, P. M., Klein, A., Koltenuk, D., Kovaltchouk, V., Liang, M., Liu, J., Lolos, G. J., Lung, A., Margaziotis, D. J., Markowitz, P., Matsumura, A., McKee, D., Meekins, D., Mitchell, J., Miyoshi, T., Mkrtchyan, H., Mueller, B., Niculescu, G., Niculescu, I., Okayasu, Y., Pentchev, L., Perdrisat, C., Pitz, D., Potterveld, D., Punjabi, V., Qin, L. M., Reimer, P. E., Reinhold, J., Roche, J., Roos, P. G., Sarty, A., Shin, I. K., Smith, G. R., Stepanyan, S., Tang, L. G., Tadevosyan, V., Tvaskis, V., van der Meer, R. L. J., Vansyoc, K., Van Westrum, D., Vidakovic, S., Volmer, J., Vulcan, W., Warren, G., Wood, S. A., Xu, C., Yan, C., Zhao, W. -X., Zheng, X., Zihlmann, B., and Collaboration, The Jefferson Lab Fpi

Subjects
Nuclear Experiment
Abstract

Background: Measurements of forward exclusive meson production at different squared four-momenta of the exchanged virtual photon, $Q^2$, and at different four-momentum transfer, t, can be used to probe QCD's transition from meson-nucleon degrees of freedom at long distances to quark-gluon degrees of freedom at short scales. Ratios of separated response functions in $\pi^-$ and $\pi^+$ electroproduction are particularly informative. The ratio for transverse photons may allow this transition to be more easily observed, while the ratio for longitudinal photons provides a crucial verification of the assumed pole dominance, needed for reliable extraction of the pion form factor from electroproduction data. Method: Data were acquired with 2.6-5.2 GeV electron beams and the HMS+SOS spectrometers in Jefferson Lab Hall C, at central $Q^2$ values of 0.6, 1.0, 1.6 GeV$^2$ at W=1.95 GeV, and $Q^2$=2.45 GeV$^2$ at W=2.22 GeV. There was significant coverage in $\phi$ and $\epsilon$, which allowed separation of $\sigma_{L,T,LT,TT}$. Results: $\sigma_L$ shows a clear signature of the pion pole, with a sharp rise at small -t. In contrast, $\sigma_T$ is much flatter versus t. The longitudinal/transverse ratios evolve with $Q^2$ and t, and at the highest $Q^2$=2.45 GeV$^2$ show a slight enhancement for $\pi^-$ production compared to $\pi^+$. The $\pi^-/\pi^+$ ratio for transverse photons exhibits only a small $Q^2$-dependence, following a nearly universal curve with t, with a steep transition to a value of about 0.25, consistent with s-channel quark knockout. The $\sigma_{TT}/\sigma_T$ ratio also drops rapidly with $Q^2$, qualitatively consistent with s-channel helicity conservation. The $\pi^-/\pi^+$ ratio for longitudinal photons indicates a small isoscalar contamination at W=1.95 GeV, consistent with what was observed in our earlier determination of the pion form factor at these kinematics., Comment: 25 pages, 16 figures, 6 tables

Published
2014
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11. Separated Response Function Ratios in Exclusive, Forward pi^{+/-} Electroproduction

Author

Huber, G. M., Blok, H. P., Butuceanu, C., Gaskell, D., Horn, T., Mack, D. J., Abbott, D., Aniol, K., Anklin, H., Armstrong, C., Arrington, J., Assamagan, K., Avery, S., Baker, O. K., Barrett, B., Beise, E. J., Bochna, C., Boeglin, W., Brash, E. J., Breuer, H., Chang, C. C., Chant, N., Christy, M. E., Dunne, J., Eden, T., Ent, R., Fenker, H., Gibson, E. F., Gilman, R., Gustafsson, K., Hinton, W., Holt, R. J., Jackson, H., Jin, S., Jones, M. K., Keppel, C. E., Kim, P. H., Kim, W., King, P. M., Klein, A., Koltenuk, D., Kovaltchouk, V., Liang, M., Liu, J., Lolos, G. J., Lung, A., Margaziotis, D. J., Markowitz, P., Matsumura, A., McKee, D., Meekins, D., Mitchell, J., Miyoshi, T., Mkrtchyan, H., Mueller, B., Niculescu, G., Niculescu, I., Okayasu, Y., Pentchev, L., Perdrisat, C., Pitz, D., Potterveld, D., Punjabi, V., Qin, L. M., Reimer, P. E., Reinhold, J., Roche, J., Roos, P. G., Sarty, A., Shin, I. K., Smith, G. R., Stepanyan, S., Tang, L. G., Tadevosyan, V., Tvaskis, V., van der Meer, R. L. J., Vansyoc, K., Van Westrum, D., Vidakovic, S., Volmer, J., Vulcan, W., Warren, G., Wood, S. A., Xu, C., Yan, C., Zhao, W. -X., Zheng, X., and Zihlmann, B.

Subjects
Nuclear Experiment
Abstract

The study of exclusive $\pi^{\pm}$ electroproduction on the nucleon, including separation of the various structure functions, is of interest for a number of reasons. The ratio $R_L=\sigma_L^{\pi^-}/\sigma_L^{\pi^+}$ is sensitive to isoscalar contamination to the dominant isovector pion exchange amplitude, which is the basis for the determination of the charged pion form factor from electroproduction data. A change in the value of $R_T=\sigma_T^{\pi^-}/\sigma_T^{\pi^+}$ from unity at small $-t$, to 1/4 at large $-t$, would suggest a transition from coupling to a (virtual) pion to coupling to individual quarks. Furthermore, the mentioned ratios may show an earlier approach to pQCD than the individual cross sections. We have performed the first complete separation of the four unpolarized electromagnetic structure functions above the dominant resonances in forward, exclusive $\pi^{\pm}$ electroproduction on the deuteron at central $Q^2$ values of 0.6, 1.0, 1.6 GeV$^2$ at $W$=1.95 GeV, and $Q^2=2.45$ GeV$^2$ at $W$=2.22 GeV. Here, we present the $L$ and $T$ cross sections, with emphasis on $R_L$ and $R_T$, and compare them with theoretical calculations. Results for the separated ratio $R_L$ indicate dominance of the pion-pole diagram at low $-t$, while results for $R_T$ are consistent with a transition between pion knockout and quark knockout mechanisms., Comment: 6 pages, 3 figures

Published
2014
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13. Virtual Compton Scattering and the Generalized Polarizabilities of the Proton at Q^2=0.92 and 1.76 GeV^2

Author

Fonvieille, H., Laveissiere, G., Degrande, N., Jaminion, S., Jutier, C., Todor, L., Di Salvo, R., Van Hoorebeke, L., Alexa, L. C., Anderson, B. D., Aniol, K. A., Arundell, K., Audit, G., Auerbach, L., Baker, F. T., Baylac, M., Berthot, J., Bertin, P. Y., Bertozzi, W., Bimbot, L., Boeglin, W. U., Brash, E. J., Breton, V., Breuer, H., Burtin, E., Calarco, J. R., Cardman, L. S., Cavata, C., Chang, C. -C., Chen, J. -P., Chudakov, E., Cisbani, E., Dale, D. S., deJager, C. W., De Leo, R., Deur, A., d'Hose, N., Dodge, G. E., Domingo, J. J., Elouadrhiri, L., Epstein, M. B., Ewell, L. A., Finn, J. M., Fissum, K. G., Fournier, G., Frois, B., Frullani, S., Furget, C., Gao, H., Gao, J., Garibaldi, F., Gasparian, A., Gilad, S., Gilman, R., Glamazdin, A., Glashausser, C., Gomez, J., Gorbenko, V., Grenier, P., Guichon, P. A. M., Hansen, J. O., Holmes, R., Holtrop, M., Howell, C., Huber, G. M., Hyde, C. E., Incerti, S., Iodice, M., Jardillier, J., Jones, M. K., Kahl, W., Kato, S., Katramatou, A. T., Kelly, J. J., Kerhoas, S., Ketikyan, A., Khayat, M., Kino, K., Kox, S., Kramer, L. H., Kumar, K. S., Kumbartzki, G., Kuss, M., Leone, A., LeRose, J. J., Liang, M., Lindgren, R. A., Liyanage, N., Lolos, G. J., Lourie, R. W., Madey, R., Maeda, K., Malov, S., Manley, D. M., Marchand, C., Marchand, D., Margaziotis, D. J., Markowitz, P., Marroncle, J., Martino, J., McCormick, K., McIntyre, J., Mehrabyan, S., Merchez, F., Meziani, Z. E., Michaels, R., Miller, G. W., Mougey, J. Y., Nanda, S. K., Neyret, D., Offermann, E. A. J. M., Papandreou, Z., Pasquini, B., Perdrisat, C. F., Perrino, R., Petratos, G. G., Platchkov, S., Pomatsalyuk, R., Prout, D. L., Punjabi, V. A., Pussieux, T., Quemener, G., Ransome, R. D., Ravel, O., Real, J. S., Renard, F., Roblin, Y., Rowntree, D., Rutledge, G., Rutt, P. M., Saha, A., Saito, T., Sarty, A. J., Serdarevic, A., Smith, T., Smirnov, G., Soldi, K., Sorokin, P., Souder, P. A., Suleiman, R., Templon, J. A., Terasawa, T., Tieulent, R., Tomasi-Gustaffson, E., Tsubota, H., Ueno, H., Ulmer, P. E., Urciuoli, G. M., Vanderhaeghen, M., Van der Meer, R. L. J., Van De Vyver, R., Vernin, P., Vlahovic, B., Voskanyan, H., Voutier, E., Watson, J. W., Weinstein, L. B., Wijesooriya, K., Wilson, R., Wojtsekhowski, B. B., Zainea, D. G., Zhang, W. -M., Zhao, J., and Zhou, Z. -L.

Subjects
Nuclear Experiment, High Energy Physics - Experiment
Abstract

Virtual Compton Scattering (VCS) on the proton has been studied at Jefferson Lab using the exclusive photon electroproduction reaction (e p --> e p gamma). This paper gives a detailed account of the analysis which has led to the determination of the structure functions P_LL-P_TT/epsilon and P_LT, and the electric and magnetic generalized polarizabilities (GPs) alpha_E(Q^2) and beta_M(Q^2) at values of the four-momentum transfer squared Q^2= 0.92 and 1.76 GeV^2. These data, together with the results of VCS experiments at lower momenta, help building a coherent picture of the electric and magnetic GPs of the proton over the full measured Q^2-range, and point to their non-trivial behavior., Comment: version 2: modified according to PRC Editor's and Referee's recommendations. Archival paper for the E93-050 experiment at JLab Hall A. 28 pages, 23 figures, 5 cross-section tables. To be submitted to Phys.Rev.C

Published
2012
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14. Charged pion form factor between $Q^2$=0.60 and 2.45 GeV$^2$. I. Measurements of the cross section for the ${^1}$H($e,e'\pi^+$)$n$ reaction

Author

Blok, H. P., Horn, T., Huber, G. M., Beise, E. J., Gaskell, D., Mack, D. J., Tadevosyan, V., Volmer, J., Abbott, D., Aniol, K., Anklin, H., Armstrong, C., Arrington, J., Assamagan, K., Avery, S., Baker, O. K., Barrett, B., Bochna, C., Boeglin, W., Brash, E. J., Breuer, H., Chang, C. C., Chant, N., Christy, M. E., Dunne, J., Eden, T., Ent, R., Fenker, H., Gibson, E., Gilman, R., Gustafsson, K., Hinton, W., Holt, R. J., Jackson, H., Jin, S., Jones, M. K., Keppel, C. E., Kim, P. H., Kim, W., King, P. M., Klein, A., Koltenuk, D., Kovaltchouk, V., Liang, M., Liu, J., Lolos, G. J., Lung, A., Margaziotis, D. J., Markowitz, P., Matsumura, A., McKee, D., Meekins, D., Mitchell, J., Miyoshi, T., Mkrtchyan, H., Mueller, B., Niculescu, G., Niculescu, I., Okayasu, Y., Pentchev, L., Perdrisat, C., Pitz, D., Potterveld, D., Punjabi, V., Qin, L. M., Reimer, P., Reinhold, J., Roche, J., Roos, P. G., Sarty, A., Shin, I. K., Smith, G. R., Stepanyan, S., Tang, L. G., Tvaskis, V., van der Meer, R. L. J., Vansyoc, K., Van Westrum, D., Vidakovic, S., Vulcan, W., Warren, G., Wood, S. A., Xu, C., Yan, C., Zhao, W. -X., Zheng, X., and Zihlmann, B.

Subjects
Nuclear Experiment
Abstract

Cross sections for the reaction ${^1}$H($e,e'\pi^+$)$n$ were measured in Hall C at Thomas Jefferson National Accelerator Facility (JLab) using the CEBAF high-intensity, continous electron beam in order to determine the charged pion form factor. Data were taken for central four-momentum transfers ranging from $Q^2$=0.60 to 2.45 GeV$^2$ at an invariant mass of the virtual photon-nucleon system of $W$=1.95 and 2.22 GeV. The measured cross sections were separated into the four structure functions $\sigma_L$, $\sigma_T$, $\sigma_{LT}$, and $\sigma_{TT}$. The various parts of the experimental setup and the analysis steps are described in detail, including the calibrations and systematic studies, which were needed to obtain high precision results. The different types of systematic uncertainties are also discussed. The results for the separated cross sections as a function of the Mandelstam variable $t$ at the different values of $Q^2$ are presented. Some global features of the data are discussed, and the data are compared with the results of some model calculations for the reaction ${^1}$H($e,e'\pi^+$)$n$., Comment: 26 pages, 23 figures

Published
2008
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15. Charged pion form factor between Q^2=0.60 and 2.45 GeV^2. II. Determination of, and results for, the pion form factor

Author

Huber, G. M., Blok, H. P., Horn, T., Beise, E. J., Gaskell, D., Mack, D. J., Tadevosyan, V., Volmer, J., Abbott, D., Aniol, K., Anklin, H., Armstrong, C., Arrington, J., Assamagan, K., Avery, S., Baker, O. K., Barrett, B., Bochna, C., Boeglin, W., Brash, E. J., Breuer, H., Chang, C. C., Chant, N., Christy, M. E., Dunne, J., Eden, T., Ent, R., Gibson, E., Gilman, R., Gustafsson, K., Hinton, W., Holt, R. J., Jackson, H., Jin, S., Jones, M. K., Keppel, C. E., Kim, P. H., Kim, W., King, P. M., Klein, A., Koltenuk, D., Kovaltchouk, V., Kiang, M., Liu, J., Lolos, G. J., Lung, A., Margaziotis, D. J., Markowitz, P., Matsumura, A., McKee, D., Meekins, D., Mitchell, J., Miyoshi, T., Mkrtchyan, H., Mueller, B., Niculescu, G., Niculescu, I., Okayasu, Y., Pentchev, L., Perdrisat, C., Pitz, D., Potterveld, D., Punjabi, V., Qin, L. M., Reimer, P., Reinhold, J., Roche, J., Roos, P. G., Sarty, A., Shin, I. K., Smith, G. R., Stepanyan, S., Tang, L. G., Tvaskis, V., van der Meer, R. L. J., Vansyoc, K., Van Westrum, D., Vidakovic, S., Vulcan, W., Warren, G., Wood, S. A., Xu, C., Yan, C., Zhao, W. -X., Zheng, X., and Zihlmann, B.

Subjects
Nuclear Experiment
Abstract

The charged pion form factor, Fpi(Q^2), is an important quantity which can be used to advance our knowledge of hadronic structure. However, the extraction of Fpi from data requires a model of the 1H(e,e'pi+)n reaction, and thus is inherently model dependent. Therefore, a detailed description of the extraction of the charged pion form factor from electroproduction data obtained recently at Jefferson Lab is presented, with particular focus given to the dominant uncertainties in this procedure. Results for Fpi are presented for Q^2=0.60-2.45 GeV^2. Above Q^2=1.5 GeV^2, the Fpi values are systematically below the monopole parameterization that describes the low Q^2 data used to determine the pion charge radius. The pion form factor can be calculated in a wide variety of theoretical approaches, and the experimental results are compared to a number of calculations. This comparison is helpful in understanding the role of soft versus hard contributions to hadronic structure in the intermediate Q^2 regime., Comment: 18 pages, 11 figures

Published
2008
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16. 3He Spin-Dependent Cross Sections and Sum Rules

Author

E94010 Collaboration, Slifer, K., Amarian, M., Auerbach, L., Averett, T., Berthot, J., Bertin, P., Bertozzi, B., Black, T., Brash, E., Brown, D., Burtin, E., Calarco, J., Cates, G., Chai, Z., Chen, J. -P., Choi, Seonho, Chudakov, E., Atti, C. Ciofi degli, Cisbani, E., de Jager, C. W., Deur, A., DiSalvo, R., Dieterich, S., Djawotho, P., Finn, M., Fissum, K., Fonvieille, H., Frullani, S., Gao, H., Gao, J., Garibaldi, F., Gasparian, A., Gilad, S., Gilman, R., Glamazdin, A., Glashausser, C., Glockle, W., Golak, J., Goldberg, E., Gomez, J., Gorbenko, V., Hansen, J. -O., Hersman, B., Holmes, R., Huber, G. M., Hughes, E., Humensky, B., Incerti, S., Iodice, M., Jensen, S., Jiang, X., Jones, C., Jones, G., Jones, M., Jutier, C., Kamada, H., Ketikyan, A., Kominis, I., Korsch, W., Kramer, K., Kumar, K., Kumbartzki, G., Kuss, M., Lakuriqi, E., Laveissiere, G., Lerose, J. J., Liang, M., Liyanage, N., Lolos, G., Malov, S., Marroncle, J., McCormick, K., McKeown, R. D., Meziani, Z. -E., Michaels, R., Mitchell, J., Nogga, A., Pace, E., Papandreou, Z., Pavlin, T., Petratos, G. G., Pripstein, D., Prout, D., Ransome, R., Roblin, Y., Rowntree, D., Rvachev, M., Sabatie, F., Saha, A., Salme, G., Scopetta, S., Skibinski, R., Souder, P., Saito, T., Strauch, S., Suleiman, R., Takahashi, K., Teijiro, S., Todor, L., Tsubota, H., Ueno, H., Urciuoli, G., Van der Meer, R., Vernin, P., Voskanian, H., Witala, H., Wojtsekhowski, B., Xiong, F., Xu, W., Yang, J. -C., Zhang, B., and Zolnierczuk, P.

Subjects
Nuclear Experiment
Abstract

We present a measurement of the spin-dependent cross sections for the \vec{^3He}(\vec{e},e')X} reaction in the quasielastic and resonance regions at four-momentum transfer 0.1 < Q^2< 0.9 GeV^2. The spin-structure functions have been extracted and used to evaluate the nuclear Burkhardt--Cottingham and extended GDH sum rules for the first time. Impulse approximation and exact three-body Faddeev calculations are also compared to the data in the quasielastic region., Comment: Final version

Published
2008
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17. Determination of the pion charge form factor for Q^2=0.60-1.60 GeV^2

Author

collaboration, The Fpi-1, Tadevosyan, V., Blok, H. P., Huber, G. M., Abbott, D., Anklin, H., Armstrong, C., Arrington, J., Assamagan, K., Avery, S., Baker, O. K., Bochna, C., Brash, E. J., Breuer, H., Chant, N., Dunne, J., Eden, T., Ent, R., Gaskell, D., Gilman, R., Gustafsson, K., Hinton, W., Jackson, H., Jones, M. K., Keppel, C., Kim, P. H., Kim, W., Klein, A., Koltenuk, D., Liang, M., Lolos, G. J., Lung, A., Mack, D. J., McKee, D., Meekins, D., Mitchell, J., Mkrtchyan, H., Mueller, B., Niculescu, G. Niculescu I., Pitz, D., Potterveld, D., Qin, L. M., Reinhold, J., Shin, I. K., Stepanyan, S., Tang, L. G., van der Meer, R. L. J., Vansyoc, K., Van Westrum, D., Volmer, J., Vulcan, W., Wood, S., Yan, C., Zhao, W. -X., and Zihlmann, B.

Subjects
Nuclear Experiment
Abstract

The data analysis for the reaction H(e,e' pi^+)n, which was used to determine values for the charged pion form factor Fpi for values of Q^2=0.6-1.6 GeV^2, has been repeated with careful inspection of all steps and special attention to systematic uncertainties. Also the method used to extract Fpi from the measured longitudinal cross section was critically reconsidered. Final values for the separated longitudinal and transverse cross sections and the extracted values of Fpi are presented., Comment: 11 pages, 6 figures

Published
2006
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18. Simultaneous X-ray and UV spectroscopy of the Seyfert 1 galaxy NGC 5548.II. Physical conditions in the X-ray absorber

Author

Steenbrugge, K. C., Kaastra, J. S., Crenshaw, D. M., Kraemer, S. B., Arav, N., George, I. M., Liedahl, D. A., van der Meer, R. L. J., Paerels, F. B. S., Turner, T. J., and Yaqoob, T.

Subjects
Astrophysics
Abstract

We present the results from a 500 ks Chandra observation of the Seyfert 1 galaxy NGC 5548. We detect broadened emission lines of O VII and C VI in the spectra, similar to those observed in the optical and UV bands. The source was continuously variable, with a 30 % increase in luminosity in the second half of the observation. No variability in the warm absorber was detected between the spectra from the first 170 ks and the second part of the observation. The velocity structure of the X-ray absorber is consistent with the velocity structure measured simultaneously in the ultraviolet spectra. We find that the highest velocity outflow component, at -1040 km/s, becomes increasingly important for higher ionization parameters. This velocity component spans at least three orders of magnitude in ionization parameter, producing both highly ionized X-ray absorption lines (Mg XII, Si XIV) as well as UV absorption lines. A similar conclusion is very probable for the other four velocity components. Based upon our observations, we argue that the warm absorber probably does not manifest itself in the form of photoionized clumps in pressure equilibrium with a surrounding wind. Instead, a model with a continuous distribution of column density versus ionization parameter gives an excellent fit to our data. From the shape of this distribution and the assumption that the mass loss through the wind should be smaller than the accretion rate onto the black hole, we derive upper limits to the solid angle as small as 10^{-4} sr. From this we argue that the outflow occurs in density-stratified streamers. The density stratification across the stream then produces the wide range of ionization parameter observed in this source. Abridged., Comment: 21 pages, 12 figures accepted for publication in A&A

Published
2005
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19. Simultaneous X-ray and Ultraviolet spectroscopy of the Seyfert galaxy NGC 5548. III. X-ray time variability

Author

Kaastra, J. S., Steenbrugge, K. C., Crenshaw, D. M., Kraemer, S. B., Arav, N., George, I. M., Liedahl, D. A., van der Meer, R. L. J., Paerels, F. B. S., Turner, T. J., and Yaqoob, T.

Subjects
Astrophysics
Abstract

The Seyfert 1 galaxy NGC 5548 was observed for a week by Chandra using both the HETGS and LETGS spectrometers. In this paper we study the time variability of the continuum radiation. During our observation, the source showed a gradual increase in flux over four days, followed by a rapid decrease and flattening of the light curve afterwards. Superimposed upon these relatively slow variations several short duration bursts or quasi-periodic oscillations occured with a typical duration of several hours and separation between 0.6-0.9 days. The bursts show a delay of the hard X-rays with respect to the soft X-rays of a few hours. We interprete these bursts as due to a rotating, fluctuating hot spot at approximately 10 gravitational radii; the time delay of the hard X-rays from the bursts agree with the canonical picture of Inverse Compton scattering of the soft accretion disk photons on a hot medium that is relatively close to the central black hole., Comment: 6 pages, 7 figures, accepted for publication in Astronomy and Astrophysics

Published
2004
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20. AD Leonis: Flares observed by XMM-Newton and Chandra

Author

Besselaar, E. J. M. van den, Raassen, A. J. J., Mewe, R., van der Meer, R. L. J., Guedel, M., and Audard, M.

Subjects
Astrophysics
Abstract

The M-dwarf AD Leonis has been observed with the Reflection Grating Spectrometers and the European Photon Imaging Camera aboard XMM-Newton and also with the Low Energy Transmission Grating Spectrometer aboard the Chandra X-ray Observatory. In the observation taken with XMM-Newton five large flares produced by AD Leo were identified and only one in the observation taken with Chandra. A quiescent level to the lightcurves is difficult to define, since several smaller flares mutually overlap each other. However, we defined a quasi-steady state outside of obvious flares or flare decays. The spectra from the flare state and the quasi-steady state are analysed separately. From these spectra the temperature structure was derived with a multi-temperature model and with a differential emission measure model. The multi-temperature model was also used to determine the relative abundances of C, N, O, Ne, Mg, Si, S, and Fe. He-like ions, such as O VII and Ne IX, produce line triplets which are used to determine or constrain the electron temperature and electron density of the corresponding ion. During the flare state a higher emission measure at the hottest temperature is found for both XMM-Newton and Chandra observations. The derived abundances suggest the presence of an inverse First Ionization Potential effect in the corona of AD Leo., Comment: 8 pages and 7 figures. Accepted for publication in Astronomy & Astrophysics

Published
2003
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21. The Soft X-ray Spectrum from NGC 1068 Observed with LETGS on Chandra

Author

Brinkman, A. C., Kaastra, J. S., van der Meer, R. L. J., Kinkhabwala, A., Behar, E., Kahn, S. M., Paerels, F. B. S., and Sako, M.

Subjects
Astrophysics
Abstract

Using the combined spectral and spatial resolving power of the Low Energy Transmission Grating (LETGS) on board Chandra, we obtain separate spectra from the bright central source of NGC 1068 (Primary region), and from a fainter bright spot 4" to the NE (Secondary region). Both spectra are dominated by line emission from H- and He-like ions of C through S, and from Fe L-shell ions, but also include narrow radiative recombination continua, indicating that most of the soft X-ray emission arises in low-temperature (kT few eV) photoionized plasma. We confirm the conclusions of Kinkhabwala et al. (2002), based on XMM-Newton RGS observations, that the entire nuclear spectrum can be explained by recombination/radiative cascade following photoionization, and radiative decay following photoexcitation, with no evidence for hot, collisionally ionized plasma. In addition, this model also provides an excellent fit to the spectrum of the Secondary region, albeit with radial column densities a factor of three lower, as would be expected given its distance from the source of the ionizing continuum. The remarkable overlap and kinematical agreement of the optical and X-ray line emission, coupled with the need for a distribution of ionization parameter to explain the X-ray spectra, collectively imply the presence of a distribution of densities (over a few orders of magnitude) at each radius in the ionization cone. Relative abundances of all elements are consistent with Solar abundance, except for N, which is 2-3 times Solar. The long wavelength spectrum beyond 30 A is rich of L-shell transitions of Mg, Si, S, and Ar, and M-shell transitions of Fe. The velocity dispersion decreases with increasing ionization parameter, as deduced from these long wavelength lines and the Fe-L shell lines., Comment: 12 pages, 11 figures, accepted for publication in Astronomy and Astrophysics

Published
2002
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22. Coronal density diagnostics with Helium-like triplets: CHANDRA--LETGS observations of Algol, Capella, Procyon, Eps Eri, Alpha Cen A&B, UX Ari, AD Leo, YY Gem, and HR1099

Author

Ness, J. -U., Schmitt, J. H. M. M., Burwitz, V., Mewe, R., Raassen, A. J. J., van der Meer, R. L. J., Predehl, P., and Brinkman, A. C.

Subjects
Astrophysics
Abstract

We present an analysis of ten cool stars (Algol, Capella, Procyon, Eps Eri, Alpha Cen A&B, UX Ari, AD Leo, YY Gem, and HR1099) observed with the Low Energy Transmission Grating Spectrometer (LETGS) on board the Chandra X-ray Observatory. This sample contains all cools stars observed with the LETGS presently available to us with integration times sufficiently long to warrant a meaningful spectral analysis. Our sample comprises inactive, moderately active, and hyperactive stars and samples the bulk part of activity levels encountered in coronal X-ray sources. We use the LETGS spectra to carry out density and temperature diagnostics with an emphasis on the H-like and the He-like ions. We find a correlation between line flux ratios of the Lyman-Alpha and He-like resonance lines with the mean X-ray surface flux. We determine densities using the He-like triplets. For active stars we find no significant deviations from the low-density limit for the ions of Ne, Mg, and Si, while the measured line ratios for the ions of C, N, and O do show evidence for departures from the low-density limit in the active stars, but not in the inactive stars. Best measurements can be made for the OVII triplet where we find significant deviations from the low-density limit for the stars Algol, Procyon, YY Gem, Eps Eri, and HR1099. We discuss the influence of radiation fields on the interpretation of the He-like triplet line ratios in the low-Z ions, which is relevant for Algol, and the influence of dielectronic satellite lines, which is relevant for Procyon. For the active stars YY Gem, Eps Eri, and HR1099 the low f/i ratios can unambiguously be attributed to high densties in the range 1--3 10^10 cm^-3 at OVII temperatures. We find our LETGS spectra to be an extremely useful tool for plasma diagnostics of stellar coronae., Comment: 17 pages, Latex2e, 12 figures. accepted for A&A under MS2627

Published
2002
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23. High-resolution X-ray spectroscopy of Procyon by Chandra and XMM-Newton

Author

Raassen, A. J. J., Mewe, R., Audard, M., Guedel, M., Behar, E., Kaastra, J. S., van der Meer, R. L. J., Foley, C. R., and Ness, J. -U.

Subjects
Astrophysics
Abstract

We report the analysis of the high-resolution soft X-ray spectrum of the nearby F-type star Procyon in the wavelength range from 5 to 175 Angstrom obtained with the Low Energy Transmission Grating Spectrometer (LETGS) on board Chandra and with the Reflection Grating Spectrometers (RGS) and the EPIC-MOS CCD spectrometers on board XMM-Newton. Line fluxes have been measured separately for the RGS and LETGS. Spectra have been fitted globally to obtain self-consistent temperatures, emission measures, and abundances. The total volume emission measure is ~4.1 x 10e50/cm3 with a peak between 1 and 3 MK. No indications for a dominant hot component (T > 4 MK) were found. We present additional evidence for the lack of a solar-type FIP-effect, confirming earlier EUVE results., Comment: 10 pages, 9 figures, A&A accepted

Published
2002
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24. Soft X-ray Spectroscopy of NGC 1068 with XMM-Newton RGS and Chandra LETGS

Author

Kinkhabwala, A., Sako, M., Behar, E., Kahn, S. M., Paerels, F., Brinkman, A. C., Kaastra, J. S., van der Meer, R. L. J., Gu, M. F., and Liedahl, D. A.

Subjects
Astrophysics
Abstract

We present high-resolution soft-X-ray spectra of the prototypical Seyfert 2 galaxy, NGC 1068, taken with XMM-Newton RGS and Chandra LETGS. Its rich emission-line spectrum is dominated by recombination in a warm plasma (bright, narrow radiative recombination continua provide the ``smoking gun''), which is photoionized by the inferred nuclear power-law continuum. Radiative decay following photoexcitation of resonant transitions is also significant. A self-consistent model of an irradiated cone of gas is capable of reproducing the hydrogenic/heliumlike ionic line series in detail. The radial ionic column densities we infer are consistent with absorption measurements (the warm absorber) in Seyfert 1 galaxies. This strongly suggests that the emission spectrum we observe from NGC 1068 emanates from its warm absorber. The observed extent of the ionization-cone/warm absorber in NGC 1068 of about 300 pc implies that a large fraction of the gas associated with generic warm absorbers may typically exist on the hundreds-of-parsec scale rather than much closer to the nucleus (e.g., less than a parsec). Spatially-resolved spectroscopy using the LETGS of two distinct emission regions yields two noticeably different spectra. We show that these differences are solely due to differing radial column densities. A fairly flat distribution in ionization parameter is necessary to explain the inferred radial ionic column densities of all spectra. This must primarily be due to a broad density distribution at each radius, spanning roughly 0.1-100 cm$^{-3}$. (Abridged), Comment: 9 pages, 15 figures, to appear in the proceedings of the symposium 'New Visions of the X-ray Universe in the XMM-Newton and Chandra Era', 26-30 November 2001, ESTEC, The Netherlands. Minor corrections/reference modifications (thanks to J. Krolik for pointing out)

Published
2002

25. X-ray spectroscopy of NGC 5548

Author

Kaastra, J. S., Steenbrugge, K. C., Raassen, A. J. J., van der Meer, R. L. J., Brinkman, A. C., Liedahl, D. A., Behar, E., and de Rosa, A.

Subjects
Astrophysics
Abstract

We analyze the high-resolution X-ray spectrum of the Seyfert 1 galaxy NGC 5548, for the full 0.1-10 keV band, using improved calibration results of the Chandra-LETGS instrument. The warm absorber consists of at least three ionization components, namely one with a low, medium and high ionization parameter. The X-ray absorbing material, from an outflowing wind, covers the full range of velocity components found from UV absorption lines. The presence of redshifted emission components for the strongest blue-shifted resonance absorption lines indicate that the absorber is located at a distance larger than the edge of the accretion disk. We derive an upper limit to the edge of the accretion disk of 1 light year. Absorption lines from ions of at least ten chemical elements have been detected, and in general for these elements there are no strong deviations from solar abundances. The narrow emission lines from the O VII and Ne IX forbidden and intercombination lines probably originate from much larger distances to the black hole. We find evidence for weak relativistically broadened oxygen and nitrogen emission lines from the inner parts of the accretion disk, but at a much smaller flux level than those observed in some other active galactic nuclei. In addition, there is a broad, non-relativistic C VI Ly alpha emission line that is consistent with emission lines from the inner part of the optical/UV broad line region., Comment: 18 pages, 19 figures, accepted for publication in Astronomy and Astrophysics

Published
2002
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26. The Chandra LETG and XMM-Newton Spectra of HR 1099

Author

Audard, M., Guedel, M., and van der Meer, R. L. J.

Subjects
Astrophysics
Abstract

The X-ray luminous RS CVn binary system HR 1099 has been observed on several occasions in the early phases of \textit{Chandra} and \textit{XMM-Newton}. A very hot (up to 40 MK) dominant coronal plasma has been identified from the high-resolution spectroscopic data; cooler plasma is seen down to about 3 MK. We recently obtained 100 ksec in \textit{Chandra}'s Guest Observer Program to study the corona of HR 1099 with the High-Resolution Camera (HRC-S) and the Low Energy Transmission Grating (LETG) across the complete temperature range above 1 MK. The data provide an unprecedented view of spectral lines and continua at high resolution between 1 and 175 \AA. We present our investigations on the Chandra LETGS observation of HR 1099 into the context of the latest results obtained with XMM-Newton., Comment: 4 pages, 6 figures. Proc. symposium "New Visions of the X-ray Universe in the XMM-Newton and Chandra Era" (ESA SP-488)

Published
2002

27. A Study of the Coronal Plasma in RS CVn binary systems: HR 1099 and co

Author

Audard, M., Guedel, M., Sres, A., Mewe, R., Raassen, A. J. J., Behar, E., Foley, C. R., and van der Meer, R. L. J.

Subjects
Astrophysics
Abstract

XMM-Newton has been performing comprehensive studies of X-ray luminous RS CVn binary systems in its calibration and guaranteed time programs. We present results from ongoing investigations in the context of a systematic study of coronal emission from RS CVns. We concentrate here on coronal abundances and investigate the abundance pattern in RS CVn binaries as a function of activity and average temperature. We find a transition from an Inverse First Ionization Potential (FIP) effect towards an absence of a clear trend (no FIP) in intermediately active RS CVn systems. This scheme fits well into the long-term evolution from an IFIP to a FIP effect found in solar analogs. We further study variations in the elemental abundances during a large flare., Comment: to appear in 35th ESLAB Symposium "Stellar Coronae in the Chandra and XMM-Newton Era", eds. F. Favata & J.J. Drake (San Francisco: ASP), in press

Published
2001

28. A Study of the Coronal Plasma in RS CVn binary systems

Author

Audard, M., Guedel, M., Sres, A., Mewe, R., Raassen, A. J. J., Behar, E., Foley, C. R., and van der Meer, R. L. J.

Subjects
Astrophysics
Abstract

XMM-Newton has been performing comprehensive studies of X-ray bright RS CVn binaries in its Calibration and Guaranteed Time programs. We present results from ongoing investigations in the context of a systematic study of coronal emission from RS CVns. We concentrate in this paper on coronal abundances and investigate the abundance pattern in RS CVn binaries as a function of activity and average temperature. A transition from an Inverse First Ionization Potential (FIP) effect towards an absence of a clear trend is found in intermediately active RS CVn systems. This scheme corresponds well into the long-term evolution from an IFIP to a FIP effect found in solar analogs. We further study variations in the elemental abundances during a large flare., Comment: to appear in The Twelfth Cool Stars, Stellar Systems and the Sun, eds. A. Brown, T.R. Ayres, G.M. Harper, (Boulder: Univ. of Colorado), in press

Published
2001
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29. High Resolution X-ray Spectroscopy of Seyfert 2 Galaxies

Author

Kahn, S. M., Kinkhabwala, A., Sako, M., Behar, E., Paerels, F. B. S., Brinkman, A. C., Kaastra, J. S., van der Meer, R., and Liedahl, D. A.

Subjects
Astrophysics
Abstract

X-ray spectroscopy of Seyfert 2 galaxies provides an excellent probe of the circumnuclear environment in active galactic nuclei. The grating experiments on both Chandra and XMM-Newton have now provided the first high resolution spectra of several of the brightest Seyfert 2's. We present Chandra HETG data on Markarian 3 and XMM-Newton RGS data on NGC 1068. In both cases, the spectra are dominated by emission lines due to radiative recombination following photoionization, photoexcitation, and fluorescence. There is no evidence for any significant contribution from collisionally-heated gas., Comment: 4 pages, to appear in New Century of X-ray Astronomy, ASP Conf. Ser., Vol. TBD, 2001

Published
2001

30. Soft X-ray Spectroscopy of Seyfert 2 Galaxies

Author

Kinkhabwala, A., Sako, M., Behar, E., Paerels, F., Kahn, S. M., Brinkman, A. C., Kaastra, J. S., van der Meer, R., and Liedahl, D. A.

Subjects
Astrophysics
Abstract

Soft X-ray spectroscopy of Seyfert 2 galaxies offers perhaps the best method to probe the possible connection between AGN activity and star formation. Obscuration of powerful radiation from the inferred nucleus allows for detailed study of circumnuclear emission regions. And soft X-ray spectroscopy of these regions allows for robust discrimination between warm gas radiatively driven by the AGN and hot collisionally-driven gas possibly associated with star formation. A simple model of a (bi-)cone of gas photoionized and photoexcited by a nuclear power-law continuum is sufficient to explain the soft X-ray spectra of all Seyfert 2 galaxies so far observed by the XMM-Newton and Chandra satellites. An upper limit of around 10 percent to an additional hot, collisionally-driven gas contribution to the soft X-ray regime appears to hold for five different Seyfert 2 galaxies, placing interesting constraints on circumnuclear star formation., Comment: 4 pages, to appear in The Central kpc of Starbursts and AGN, ASP Conf. Ser., Vol. TBD, 2001

Published
2001

31. A physically consistent model for X-ray emission by Seyfert 2 galaxies demonstrated on NGC 1068

Author

Behar, E., Kinkhabwala, A., Sako, M., Paerels, F., Kahn, S. M., Brinkman, A. C., Kaastra, J., and van der Meer, R.

Subjects
Astrophysics
Abstract

Preliminary analysis of the X-ray spectrum of NGC 1068 obtained by the RGS spectrometer on board XMM-Newton is presented. A physically consistent model is developed in order to quantitatively describe the reprocessing of the central AGN continuum source into the discrete X-ray emission observed in Seyfert 2 galaxies. All the important atomic processes are taken into account, including photoexcitation, which has been neglected in some previous models. The model fits the high resolution NGC 1068 data very well, which implies that the contribution of hot collisional gas to the X-ray spectrum of NGC 1068 is negligible., Comment: Submitted for the proceedings of Mass Outflows in AGNs: New Perspectives

Published
2001

32. Helium-like triplet density diagnostics: Applications to CHANDRA--LETGS X-ray observations of Capella and Procyon

Author

Ness, J. U., Mewe, R., Schmitt, J. H. M. M., Raassen, A. J. J., Porquet, D., Kaastra, J. S., van der Meer, R. L. J., Burwitz, V., and Predehl, P.

Subjects
Astrophysics
Abstract

Electron density diagnostics based on the triplets of Helium-like CV, NVI, and OVII are applied to the X-ray spectra of Capella and Procyon measured with the Low Energy Transmission Grating Spectrometer (LETGS) on board the Chandra X-ray Observatory. New theoretical models for the calculation of the line ratios between the forbidden (f), intercombination (i), and the resonance (r) lines of the helium-like triplets are used. The derived densities are quite typical of densities found in the solar active regions, and also pressures and temperatures in Procyon's and Capella's corona at a level of T=10^6K are quite similar. We find no evidence for densities as high as measured in solar flares. Comparison of our Capella and Procyon measurements with the Sun shows little difference in the physical properties of the layers producing the CV, NVI, and OVII emission. Assuming the X-ray emitting plasma to be confined in magnetic loops, we obtain typical loop length scales of L_Capella > 8 L_Procyon from the loop scaling laws, implying that the magnetic structures in Procyon and Capella are quite different. The total mean surface fluxes emitted in the helium- and hydrogen-like ions are quite similar for Capella and Procyon, but exceed typical solar values by one order of magnitude. We thus conclude that Procyon's and Capella's coronal filling factors are larger than corresponding solar values., Comment: 13 pages, Latex, fitting program Cora available at http://www.hs.uni-hamburg.de/german/persons/Ness/Software/cora-1.0.tar.gz accepted at A&A under MS10283

Published
2000
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33. Interstellar X-ray Absorption Spectroscopy of Oxygen, Neon, and Iron with the Chandra LETGS Spectrum of X0614+091

Author

Paerels, Frits, Brinkman, A. C., van der Meer, R. L. J., Kaastra, J. S., Kuulkers, E., Boggende, A. J. F. den, Predehl, P., Drake, Jeremy J., Kahn, Steven M., Savin, Daniel W., and McLaughlin, Brendan M.

Subjects
Astrophysics
Abstract

We find resolved interstellar O K, Ne K, and Fe L absorption spectra in the Chandra Low Energy Transmission Grating Spectrometer spectrum of the low mass X-ray binary X0614+091. We measure the column densities in O and Ne, and find direct spectroscopic constraints on the chemical state of the interstellar O. These measurements probably probe a low-density line of sight through the Galaxy and we discuss the results in the context of our knowledge of the properties of interstellar matter in regions between the spiral arms., Comment: 16 pages, 4 figures; ApJ, accepted

Published
2000
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34. High Resolution Spectroscopy of the X-ray Photoionized Wind in Cygnus X-3 with the Chandra High Energy Transmission Grating Spectrometer

Author

Paerels, Frits, Cottam, Jean, Sako, Masao, Liedahl, Duane A., Brinkman, A. C., van der Meer, R. L. J., Kaastra, J. S., and Predehl, P.

Subjects
Astrophysics
Abstract

We present a preliminary analysis of the 1--10 keV spectrum of the massive X-ray binary Cyg X-3, obtained with the High Energy Transmission Grating Spectrometer on the Chandra X-ray Observatory. The source reveals a richly detailed discrete emission spectrum, with clear signatures of photoionization-driven excitation. Among the spectroscopic novelties in the data are the first astrophysical detections of a number of He-like 'triplets' (Si, S, Ar) with emission line ratios characteristic of photoionization equilibrium, fully resolved narrow radiative recombination continua of Mg, Si, and S, the presence of the H-like Fe Balmer series, and a clear detection of a ~ 800 km/s large scale velocity field, as well as a ~1500 km/s FWHM Doppler broadening in the source. We briefly touch on the implications of these findings for the structure of the Wolf-Rayet wind., Comment: 11 pages, 3 figures; Accepted for publication in ApJ Letters

Published
2000
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35. First Light Measurements of Capella with the Low Energy Transmission Grating Spectrometer aboard the Chandra X-ray Observatory

Author

Brinkman, A. C., Gunsing, C. J. T., Kaastra, J. S., van der Meer, R. L. J., Mewe, R., Paerels, F., Raassen, A. J. J., van Rooijen, J. J., Bräuninger, H., Burkert, W., Burwitz, V., Hartner, G., Predehl, P., Ness, J. -U., Schmitt, J. H. M. M., Drake, J. J., Johnson, O., Juda, M., Kashyap, V., Murray, S. S., Pease, D., Ratzlaff, P., and Wargelin, B. J.

Subjects
Astrophysics
Abstract

We present the first X-ray spectrum obtained by the Low Energy Transmission Grating Spectrometer (LETGS) aboard the Chandra X-ray Observatory. The spectrum is of Capella and covers a wavelength range of 5-175 A (2.5-0.07 keV). The measured wavelength resolution, which is in good agreement with ground calibration, is $\Delta \lambda \simeq$ 0.06 A (FWHM). Although in-flight calibration of the LETGS is in progress, the high spectral resolution and unique wavelength coverage of the LETGS are well demonstrated by the results from Capella, a coronal source rich in spectral emission lines. While the primary purpose of this letter is to demonstrate the spectroscopic potential of the LETGS, we also briefly present some preliminary astrophysical results. We discuss plasma parameters derived from line ratios in narrow spectral bands, such as the electron density diagnostics of the He-like triplets of carbon, nitrogen, and oxygen, as well as resonance scattering of the strong Fe XVII line at 15.014 A., Comment: 4 pages (ApJ letter LaTeX), 2 PostScript figures, accepted for publication in ApJ Letters, 2000

Published
2000
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37. Quantum simulation of thermodynamics in an integrated quantum photonic processor

Author

Somhorst, F. H. B., primary, van der Meer, R., additional, Correa Anguita, M., additional, Schadow, R., additional, Snijders, H. J., additional, de Goede, M., additional, Kassenberg, B., additional, Venderbosch, P., additional, Taballione, C., additional, Epping, J. P., additional, van den Vlekkert, H. H., additional, Timmerhuis, J., additional, Bulmer, J. F. F., additional, Lugani, J., additional, Walmsley, I. A., additional, Pinkse, P. W. H., additional, Eisert, J., additional, Walk, N., additional, and Renema, J. J., additional

Published
2023
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39. FDA-approved drug screening in patient-derived organoids demonstrates potential of drug repurposing for rare cystic fibrosis genotypes

Author

de Poel, E., Spelier, S., Hagemeijer, M. C., van Mourik, P., Suen, S. W.F., Vonk, A. M., Brunsveld, J. E., Ithakisiou, G. N., Kruisselbrink, E., Oppelaar, H., Berkers, G., de Winter de Groot, K. M., Heida-Michel, S., Jans, S. R., van Panhuis, H., Bakker, M., van der Meer, R., Roukema, J., Dompeling, E., Weersink, E. J.M., Koppelman, G. H., Blaazer, A. R., Muijlwijk-Koezen, J. E., van der Ent, C. K., Beekman, J. M., de Poel, E., Spelier, S., Hagemeijer, M. C., van Mourik, P., Suen, S. W.F., Vonk, A. M., Brunsveld, J. E., Ithakisiou, G. N., Kruisselbrink, E., Oppelaar, H., Berkers, G., de Winter de Groot, K. M., Heida-Michel, S., Jans, S. R., van Panhuis, H., Bakker, M., van der Meer, R., Roukema, J., Dompeling, E., Weersink, E. J.M., Koppelman, G. H., Blaazer, A. R., Muijlwijk-Koezen, J. E., van der Ent, C. K., and Beekman, J. M.

Abstract

Background: Preclinical cell-based assays that recapitulate human disease play an important role in drug repurposing. We previously developed a functional forskolin induced swelling (FIS) assay using patient-derived intestinal organoids (PDIOs), allowing functional characterization of CFTR, the gene mutated in people with cystic fibrosis (pwCF). CFTR function-increasing pharmacotherapies have revolutionized treatment for approximately 85% of people with CF who carry the most prevalent F508del-CFTR mutation, but a large unmet need remains to identify new treatments for all pwCF. Methods: We used 76 PDIOs not homozygous for F508del-CFTR to test the efficacy of 1400 FDA-approved drugs on improving CFTR function, as measured in FIS assays. The most promising hits were verified in a secondary FIS screen. Based on the results of this secondary screen, we further investigated CFTR elevating function of PDE4 inhibitors and currently existing CFTR modulators. Results: In the primary screen, 30 hits were characterized that elevated CFTR function. In the secondary validation screen, 19 hits were confirmed and categorized in three main drug families: CFTR modulators, PDE4 inhibitors and tyrosine kinase inhibitors. We show that PDE4 inhibitors are potent CFTR function inducers in PDIOs where residual CFTR function is either present, or created by additional compound exposure. Additionally, upon CFTR modulator treatment we show rescue of CF genotypes that are currently not eligible for this therapy. Conclusion: This study exemplifies the feasibility of high-throughput compound screening using PDIOs. We show the potential of repurposing drugs for pwCF carrying non-F508del genotypes that are currently not eligible for therapies. One-sentence summary: We screened 1400 FDA-approved drugs in CF patient-derived intestinal organoids using the previously established functional FIS assay, and show the potential of repurposing PDE4 inhibitors and CFTR modulators for rare CF genotypes.

Published
2023
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40. FDA-approved drug screening in patient-derived organoids demonstrates potential of drug repurposing for rare cystic fibrosis genotypes

Author

Longziekten onderzoek 2, Child Health, Arts Assistenten Longziekten, Beleid & Communicatie, CTI, Translational Neuroscience, Revalidatiegeneeskunde Onderwijs, Longziekten patientenzorg, Afdeling Hartcatheterisatie, Epi Kanker Team A, Longziekten, Speerpunt Child Health, Infection & Immunity, Onderzoek, Regenerative Medicine and Stem Cells, de Poel, E., Spelier, S., Hagemeijer, M. C., van Mourik, P., Suen, S. W.F., Vonk, A. M., Brunsveld, J. E., Ithakisiou, G. N., Kruisselbrink, E., Oppelaar, H., Berkers, G., de Winter de Groot, K. M., Heida-Michel, S., Jans, S. R., van Panhuis, H., Bakker, M., van der Meer, R., Roukema, J., Dompeling, E., Weersink, E. J.M., Koppelman, G. H., Blaazer, A. R., Muijlwijk-Koezen, J. E., van der Ent, C. K., Beekman, J. M., Longziekten onderzoek 2, Child Health, Arts Assistenten Longziekten, Beleid & Communicatie, CTI, Translational Neuroscience, Revalidatiegeneeskunde Onderwijs, Longziekten patientenzorg, Afdeling Hartcatheterisatie, Epi Kanker Team A, Longziekten, Speerpunt Child Health, Infection & Immunity, Onderzoek, Regenerative Medicine and Stem Cells, de Poel, E., Spelier, S., Hagemeijer, M. C., van Mourik, P., Suen, S. W.F., Vonk, A. M., Brunsveld, J. E., Ithakisiou, G. N., Kruisselbrink, E., Oppelaar, H., Berkers, G., de Winter de Groot, K. M., Heida-Michel, S., Jans, S. R., van Panhuis, H., Bakker, M., van der Meer, R., Roukema, J., Dompeling, E., Weersink, E. J.M., Koppelman, G. H., Blaazer, A. R., Muijlwijk-Koezen, J. E., van der Ent, C. K., and Beekman, J. M.

Published
2023

41. Quantum simulation of thermodynamics in an integrated quantum photonic processor

Author

Somhorst, F. H. B., van der Meer, R., Correa Anguita, M., Schadow, Riko, Snijders, H. J., de Goede, M., Kassenberg, B., Venderbosch, P., Eisert, Jens, and Walk, Nathan

Subjects
Quantum optics, Quantum information, 500 Naturwissenschaften und Mathematik::530 Physik::530 Physik, Quantum simulation
Abstract

One of the core questions of quantum physics is how to reconcile the unitary evolution of quantum states, which is information-preserving and time-reversible, with evolution following the second law of thermodynamics, which, in general, is neither. The resolution to this paradox is to recognize that global unitary evolution of a multi-partite quantum state causes the state of local subsystems to evolve towards maximum-entropy states. In this work, we experimentally demonstrate this effect in linear quantum optics by simultaneously showing the convergence of local quantum states to a generalized Gibbs ensemble constituting a maximum-entropy state under precisely controlled conditions, while introducing an efficient certification method to demonstrate that the state retains global purity. Our quantum states are manipulated by a programmable integrated quantum photonic processor, which simulates arbitrary non-interacting Hamiltonians, demonstrating the universality of this phenomenon. Our results show the potential of photonic devices for quantum simulations involving non-Gaussian states.

Published
2023
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42. Epidemiology and management of nontuberculous mycobacterial disease in people with cystic fibrosis, the Netherlands

Author

Zomer, Domenique, primary, van Ingen, Jakko, additional, Hofland, Regina, additional, Akkerman, O.W., additional, Altenburg, J., additional, Bakker, M., additional, Bannier, M.A.G.E., additional, Conemans, L.H., additional, Gulmans, V.A.M., additional, Heijerman, H.G.M., additional, Hoek, R.A.S., additional, Janssens, H.M., additional, van der Meer, R., additional, Merkus, P.J.F.M., additional, Noordhoek, J.J., additional, Nuijsink, M., additional, Terheggen-Lagro, S.W.J., additional, van der Vaart, H., additional, and de Winter-de Groot, K.M., additional

Published
2022
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45. Human immunodeficiency virus continuum of care in 11 european union countries at the end of 2016 overall and by key population: Have we made progress?

Author

Vourli, G, Noori, T, Pharris, A, Porter, K, Axelsson, M, Begovac, J, Cazein, F, Costagliola, D, Cowan, S, Croxford, S, Monforte, A, Delpech, V, Diaz, A, Girardi, E, Gunsenheimer-Bartmeyer, B, Hernando, V, Leierer, G, Lot, F, Nunez, O, Obel, N, Op de Coul, E, Paraskeva, D, Patrinos, S, Reiss, P, Schmid, D, Sonnerborg, A, Suligoi, B, Supervie, V, van Sighem, A, Zangerle, R, Touloumi, G, Egle, A, Kanatschnig, M, Ollinger, A, Rieger, A, Schmied, B, Wallner, E, Dewasurendra, D, Gisinger, M, Kitchen, M, Plattner, A, Rieser, E, Sarcletti, M, Greil, R, Schachner, M, Skocic, M, Muller, M, Aichwalder, R, Chromy, D, Grabmeier-Pfstershammer, K, Skoll, M, Touzeau, V, Cichon, P, Wolf-Nussmuller, S, Laferl, H, Zoufaly, A, Genger-Hackl, C, Kapper, A, Schneeberger, T, Trattner, E, Schober, G, Atzl, M, Hartmann, B, Puchhammer-Stockl, E, Berg, J, Appoyer, H, Rappold, M, Strickner, S, Schindelwig, K, Ledergerber, B, Fatkenheuer, G, Gerstof, J, Kronborg, G, Pedersen, C, Larsen, C, Pedersen, G, Mohey, R, Nielsen, L, Weise, L, Kvinesdal, B, Jensen, J, Abgrall, S, Bernard, L, Billaud, E, Boue, F, Boyer, L, Cabie, A, Caby, F, Canestri, A, Cotte, L, de Truchis, P, Duval, X, Duvivier, C, Enel, P, Fischer, H, Gasnault, J, Gaud, C, Grabar, S, Khuong-Josses, M, Launay, O, Marchand, L, Mary-Krause, M, Matheron, S, Melica-Gregoire, G, Melliez, H, Meynard, J, Nacher, M, Pavie, J, Piroth, L, Poizot-Martin, I, Pradier, C, Reynes, J, Rouveix, E, Simon, A, Slama, L, Tattevin, P, Tissot-Dupont, H, Biga, J, Kurth, T, Jacquemet, N, Guiguet, M, Leclercq, S, Lievre, L, Marshall, E, Roul, H, Selinger-Leneman, H, Potard, V, Benveniste, O, Breton, G, Lupin, C, Bourzam, E, Girard, P, Fonquernie, L, Valin, N, Lefebvre, B, Sebire, M, Pialoux, G, Lebrette, M, Tibaut, P, Adda, A, Hamidi, M, Cadranel, J, Lavole, A, Parrot, A, Bouchaud, O, Vignier, N, Mechai, F, Makhlouf, S, Honore, P, Bergmann, J, Delcey, V, Lopes, A, Sellier, P, Parrinello, M, Oksenhendler, E, Gerard, L, Molina, J, Rozenbaum, W, Denis, B, De Castro, N, Lascoux, C, Yazdanpanah, Y, Lariven, S, Joly, V, Rioux, C, Poupard, M, Taverne, B, Sutton, L, Masse, V, Genet, P, Wifaq, B, Gerbe, J, Grefe, S, Dupont, C, Freire Maresca, A, Reimann, E, Bloch, M, Meier, F, Mortier, E, Zeng, F, Montoya, B, Perronne, C, Mathez, D, Marigot-Outtandy, D, Berthe, H, Greder Belan, A, Terby, A, Godin Collet, C, Marque Juillet, S, Ruquet, M, Roussin-Bretagne, S, Colardelle, P, Granier, F, Laurichesse, J, Perronne, V, Akpan, T, Marcou, M, Daneluzzi, V, Veyssier-Belot, C, Masson, H, Welker, Y, Brazille, P, Kahn, J, Zucman, D, Majerholc, C, Fourn, E, Bornarel, D, Chambrin, V, Kansau, I, Raho-Moussa, M, Lelievre, J, Saidani, M, Chesnel, C, Dumont, C, Vittecoq, D, Derradji, O, Bolliot, C, Goujard, C, Teicher, E, Mole, M, Bourdic, K, Salmon, D, Le Jeunne, C, Guet, P, Pietri, M, Pannier Metzger, E, Marcou, V, Loulergue, P, Dupin, N, Morini, J, Deleuze, J, Gerhardt, P, Chanal, J, Weiss, L, Lucas, M, Jung, C, Ptak, M, Viard, J, Ghosn, J, Gazalet, P, Cros, A, Maignan, A, Lortholary, O, Rouzaud, C, Touam, F, Benhadj, K, Consigny, P, Bossi, P, Gergely, A, Cessot, G, Durand, F, Beck-Wirth, G, Michel, C, Benomar, M, Rey, D, Partisani, M, Cheneau, C, Batard, M, Fischer, P, Leclercq, P, Blanc, M, Morand, P, Epaulard, O, Signori-Schmuck, A, Laurichesse, H, Jacomet, C, Vidal, M, Coban, D, Casanova, S, Fresard, A, Guglielminotti, C, Botelho-Nevers, E, Brunon-Gagneux, A, Ronat, V, Verdon, R, Dargere, S, Haustraete, E, Feret, P, Goubin, P, Chavanet, P, Fillion, A, Croisier, D, Gohier, S, Arvieux, C, Souala, F, Chapplain, J, Ratajczak, M, Rohan, J, Faller, J, Ruyer, O, Gendrin, V, Toko, L, Chirouze, C, Hustache-Mathieu, L, Faucher, J, Proust, A, Magy-Bertrand, N, Gil, H, Meaux-Ruault, N, Sotto, A, Rouanet, I, Mauboussin, J, Doncesco, R, Jacques, G, May, T, Rabaud, C, Andre, M, Delestan, M, Bouillon, M, Bani-Sadr, F, Rouger, C, Berger, J, Nguyen, Y, Marchou, B, Delobel, P, Martin Blondel, G, Cuzin, L, Biezunski, N, Alric, L, Bonnet, D, Guivarch, M, Palacin, A, Payssan, V, Ajana, F, Meybeck, A, Viget, N, Pugliese, P, Roger, P, Rosenthal, E, Durant, J, Cua, E, Naqvi, A, Perbost, I, Risso, K, Quinsat, D, Raphael, S, Del Giudice, P, Dides, P, Sambuc, R, Antolini-Bouvenot, M, Druart, P, Meddeb, L, Ravaux, I, Menard, A, Tomei, C, Dhiver, C, Moreau, J, Mokhtari, S, Soavi, M, Tomas, V, Bregigeon, S, Faucher, O, Obry-Roguet, V, Ritleng, A, Petit, N, Bartoli, C, Ruiz, J, Blanc, D, Allegre, T, Sordage, M, Riou, J, Faudon, C, Slama, B, Zerazhi, H, Boulat, O, Chebrek, S, Beyrne, M, Granet Brunello, P, Pellissier, L, Bonnabel, D, Cohen Valensi, R, Mouchet, B, Mboungou, G, Lafeuillade, A, Hope-Rapp, E, Hittinger, G, Philip, G, Lambry, V, Raf, F, Allavena, C, Hall, N, Reliquet, V, Chidiac, C, Ferry, T, Perpoint, T, Miailhes, P, Boibieux, A, Livrozet, J, Makhlouf, D, Brunel, F, Chiarello, P, Hoen, B, Lamaury, I, Fabre, I, Samar, K, Duvallon, E, Clavel, C, Stegmann, S, Walter, V, Adriouch, L, Huber, F, Vanticlke, V, Couppie, P, Abel, S, Pierre-Francois, S, Ricaud, C, Rodet, R, Wartel, G, Sautron, C, Poubeau, P, Borgherini, G, Camuset, G, Arasteh, K, Kowohl Vivantes, S, Schurmann, D, Warncke Charite, M, Rockstroh, J, Wasmuth, J, Hass, S, Jensen, B, Feind, C, Esser, S, Schenk-Westkamp, P, Haberl, A, Stephan, C, Plettenberg, A, Kuhlendahl, F, Adam, A, Weitner, L, Schewe, K, Goey, H, Fenske, S, Buhk, T, Stellbrink, H, Hofmann, C, Hansen, S, Degen, O, Heuer, M, Stoll, M, Gerschmann, S, Horst, H, Trautmann, S, Gillor, D, Bogner, J, Sonntag, B, Salzberger, B, Fritzsche, C, Adamis, G, Antoniadou, A, Chini, M, Chrysos, G, Gikas, A, Gogos, H, Katsarou, O, Lazanas, M, Metallidis, S, Panagopoulos, P, Paparizos, V, Papastamopoulos, V, Paraskevis, D, Psychogiou, M, Sambatakou, H, Sipsas, N, Pantazis, N, Papadopoulos, A, Nitsotolis, T, Xylomenos, G, Marangos, M, Kouramba, A, Kontos, A, Lioni, A, Tsachouridou, O, Kourkounti, S, Ganitis, A, Barbounakis, E, d'Arminio Monforte, A, Antinori, A, Andreoni, M, Castagna, A, Castelli, F, Cauda, R, Di Perri, G, Galli, M, Iardino, R, Ippolito, G, Lazzarin, A, Marchetti, G, Rezza, G, von Schloesser, F, Viale, P, Ceccherini-Silberstein, F, Cozzi-Lepri, A, Lo Caputo, S, Mussini, C, Puoti, M, Perno, C, Bai, F, Balotta, C, Bandera, A, Bonora, S, Borderi, M, Calcagno, A, Capetti, A, Capobianchi, M, Cicalini, S, Cingolani, A, Cinque, P, Di Biagio, A, Gianotti, N, Gori, A, Guaraldi, G, Lapadula, G, Lichtner, M, Madeddu, G, Maggiolo, F, Monno, L, Nozza, S, Pinnetti, C, Quiros Roldan, E, Rossotti, R, Rusconi, S, Santoro, M, Saracino, A, Sarmati, L, Fanti, I, Galli, L, Lorenzini, P, Rodano, A, Macchia, M, Tavelli, A, Carletti, F, Carrara, S, Di Caro, A, Graziano, S, Petroni, F, Prota, G, Trufa, S, Giacometti, A, Costantini, A, Barocci, V, Angarano, G, Milano, E, Suardi, C, Donati, V, Verucchi, G, Castelnuovo, F, Minardi, C, Menzaghi, B, Abeli, C, Cacopardo, B, Celesia, B, Vecchiet, J, Falasca, K, Pan, A, Lorenzotti, S, Sighinolf, L, Segala, D, Blanc, P, Vichi, F, Cassola, G, Viscoli, C, Alessandrini, A, Bobbio, N, Mazzarello, G, Fondaco, L, Bonfanti, P, Molteni, C, Chiodera, A, Milini, P, Nunnari, G, Pellicano, G, Rizzardini, G, Cannizzo, E, Moioli, M, Piolini, R, Bernacchia, D, Salpietro, S, Tincati, C, Puzzolante, C, Migliorino, C, Sangiovanni, V, Borgia, G, Esposito, V, Di Flumeri, G, Gentile, I, Rizzo, V, Cattelan, A, Marinello, S, Cascio, A, Trizzino, M, Francisci, D, Schiaroli, E, Parruti, G, Sozio, F, Magnani, G, Ursitti, M, Cristaudo, A, Vullo, V, Acinapura, R, Moschese, D, Capozzi, M, Mondi, A, Rivano Capparuccia, M, Iaiani, G, Latini, A, Gagliardini, R, Plazzi, M, De Girolamo, G, Vergori, A, Cecchetto, M, Viviani, F, De Vito, A, Rossetti, B, Montagnani, F, Franco, A, Fontana Del Vecchio, R, Di Giuli, C, Caramello, P, Orofno, G, Sciandra, M, Bassetti, M, Londero, A, Manfrin, V, Battagin, G, Starnini, G, Ialungo, A, van der Valk, M, Geerlings, S, Goorhuis, A, Hovius, J, Lempkes, B, Nellen, F, van der Poll, T, Prins, J, van Vugt, M, Wiersinga, W, Wit, F, van Duinen, M, van Eden, J, Hazenberg, A, van Hes, A, Pijnappel, F, Smalhout, S, Weijsenfeld, A, Jurriaans, S, Back, N, Zaaijer, H, Berkhout, B, Cornelissen, M, Schinkel, C, Wolthers, K, Peters, E, van Agtmael, M, Bomers, M, Sigalof, K, Heitmuller, M, Laan, L, Ang, C, van Houdt, R, Jonges, M, van Prehn, J, Kuijpers, T, Pajkrt, D, Scherpbier, H, de Boer, C, van der Plas, A, van den Berge, M, Stegeman, A, Baas, S, Hage de Loof, L, Wintermans, B, Veenemans, J, Pronk, M, Ammerlaan, H, de Munnik, E, Jansz, A, Tjhie, J, Wegdam, M, Deiman, B, Scharnhorst, V, van Eeden, A, Brokking, W, Elsenburg, L, Nobel, H, Damen, M, van Kasteren, M, Berrevoets, M, Brouwer, A, Adams, A, de Kruijf-Van de Wiel, B, Keelan-Pfaf, S, van der Ven, B, Buiting, A, Murck, J, Versteeg, D, de Vries-Sluijs, T, Bax, H, van Gorp, E, Nouwen, J, Rijnders, B, Schurink, C, Verbon, A, de Jong-Peltenburg, N, Bassant, N, van Beek, J, Vriesde, M, van Zonneveld, L, van den Berg-Cameron, H, de Groot, J, Boucher, C, Koopmans, M, van Kampen, J, Fraaij, P, van Rossum, A, Vermont, C, van der Knaap, L, Visser, E, Branger, J, Douma, R, Duijf-Van de Ven, C, Schippers, E, van Nieuwkoop, C, van IJperen, J, Geilings, J, van der Hut, G, van Burgel, N, Leyten, E, Gelinck, L, Mollema, F, Davids-Veldhuis, S, Wildenbeest, G, Heikens, E, Groeneveld, P, Bouwhuis, J, Lammers, A, Kraan, S, van Hulzen, A, Kruiper, M, van der Bliek, G, Bor, P, Bloembergen, P, Wolfagen, M, Ruijs, G, Kroon, F, de Boer, M, Scheper, H, Jolink, H, Dorama, W, van Holten, N, Claas, E, Wessels, E, den Hollander, J, El Moussaoui, R, Pogany, K, Kastelijns, M, Smit, J, Smit, E, Struik-Kalkman, D, Tearno, C, van Niekerk, T, Pontesilli, O, Lowe, S, Oude Lashof, A, Posthouwer, D, Ackens, R, Burgers, K, Schippers, J, Weijenberg-Maes, B, van Loo, I, Havenith, T, Weijer, S, van Vonderen, M, Kampschreur, L, Faber, S, Steeman-Bouma, R, Weel, J, Kootstra, G, Delsing, C, van der Burg-Van de Plas, M, Heins, H, Kortmann, W, van Twillert, G, Renckens, R, 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Boonstra, A, de Groot-De Jonge, H, van der Meulen, P, de Weerd, D, Niesters, H, van Leer-Buter, C, Knoester, M, Hoepelman, A, Arends, J, Barth, R, Bruns, A, Ellerbroek, P, Mudrikova, T, Oosterheert, J, de Regt, M, Schadd, E, van Zoelen, M, Aarsman, K, Grifoen-Van Santen, B, de Kroon, I, van Rooijen, C, van Berkel, M, Schuurman, R, Verduyn-Lunel, F, Wensing, A, Bont, L, Geelen, S, Loefen, Y, Wolfs, T, Nauta, N, Zaheri, S, Boyd, A, Bezemer, D, Smit, C, Hillebregt, M, de Jong, A, Woudstra, T, Bergsma, D, Meijering, R, van de Sande, L, Rutkens, T, van der Vliet, S, de Groot, L, van den Akker, M, Bakker, Y, El Berkaoui, A, Bezemer, M, Bretin, N, Djoechro, E, Geerlinks, J, Kruijne, E, Lodewijk, C, Lucas, E, van der Meer, R, Munjishvili, L, Paling, F, Peeck, B, Ree, C, Regtop, R, Ruijs, Y, Schoorl, M, Schnorr, P, Tuijn, E, Veenenberg, L, Witte, E, Tuk, B, Moreno, S, del Amo, J, Dalmau, D, Navarro, M, Gonzalez, M, Blanco, J, Garcia, F, Rubio, R, Iribarren, J, Gutierrez, F, Vidal, F, Berenguer, J, Gonzalez, J, Sobrino, P, Alejos, B, Alvarez, D, Jarrin, I, Moreno, C, Munoz-Fernandez, M, Garcia-Merino, I, Rico, C, de la Fuente, J, Torre, A, Portilla, J, Merino, E, Reus, S, Boix, V, Giner, L, Gadea, C, Portilla, I, Pampliega, M, Diez, M, Rodriguez, J, Sanchez-Paya, J, Podzamczer, D, Imaz, E, Van Den Eyncle, E, Di Yacovo, S, Sumoy, M, Gomez, J, Hernandez, J, Aleman, M, Alonso, M, Hernandez, M, Diaz-Flores, F, Garcia, D, Pelazas, R, Asensi, V, Valle, E, Carton, J, Perez, V, Molina, M, Garcia, J, Carrera, E, Pulido, F, Bisbal, O, Matarranz, M, Lagarde, M, Rubio-Martin, R, Hernando, A, Bermejo, L, Dominguez, L, Arrizabalaga, J, Aramburu, M, Camino, X, Rodriguez-Arrondo, F, von Wichmann, M, Tome, L, Goenaga, M, Bustinduy, M, Galparsoro, H, Ibarguren, M, Aguado, M, Umerez, M, Masia, M, Lopez, C, Padilla, S, Navarro, A, Montolio, F, Robledano, C, Colome, J, Adsuar, A, Pascual, R, Carlos, F, Martinez, M, Fernandez, M, Garcia, E, Muga, R, Tor, J, Sanvisens, A, Bernaldo de Quiros Lopez, J, Miralles, P, Gutierrez, I, Ramirez, M, Padilla, B, Gijon, P, Carrero, A, Aldamiz-Echevarria, T, Tejerina, F, Parras, F, Balsalobre, P, Diez, C, Peraire, J, Vilades, C, Veloso, S, Vargas, M, Lopez-Dupla, M, Olona, M, Aguilar, A, Sirvent, J, Alba, V, Calavia, O, Montero, M, Lacruz, J, Blanes, M, Calabuig, E, Cuellar, S, Lopez, J, Salavert, M, de la Serna, I, Arribas, J, Montes, M, Pena, J, Arribas, B, Castro, J, Zamora, J, Perez, I, Estebanez, M, Garcia, S, Diaz, M, Alcariz, N, Mingorance, J, Montero, D, Gonzalez, A, Isabel de Jose, M, de los Santos, I, Sanz, J, Salas, A, Sarria, C, Berrocal, A, Garcia-Fraile, L, Oteo, J, Ibarra, V, Metola, L, Sanz, M, Perez-Martinez, L, Pascual, A, Ramos, C, Arazo, P, Gil, D, Jaen, A, Cairo, M, Irigoyen, D, Jordano, Q, Xercavins, M, Martinez-Lacasa, J, Velli, P, Font, R, Sanmarti, M, Ibanez, L, Rivero, M, Casado, M, Diaz, J, Uriz, J, Reparaz, J, Irigoyen, C, Arraiza, M, Segura, F, Amengual, M, Navarro, G, Sala, M, Cervantes, M, Pineda, V, Segura, V, Anton, E, Nogueras, M, Casado, J, Dronda, F, Moreno, A, Elias, M, Lopez, D, Gutierrez, C, Madrid, N, Lamas, A, Marti, P, de Diaz, A, Serrrano, S, Donat, L, Cano, A, Bernal, E, Munoz, A, Pena, A, Munoz, L, Parra, J, Alvarez, M, Chueca, N, Guillot, V, Vinuesa, D, Fernandez, J, Del Romero, J, Rodriguez, C, Puerta, T, Carrio, J, Vera, M, Ballesteros, J, Domingo, P, Sambeat, M, Lamarca, K, Mateo, G, Gutierrez, M, Fernandez, I, Antela, A, Losada, E, Riera, M, Penaranda, M, Leyes, M, Ribas, M, Campins, A, Vidal, C, Gil, L, Fanjul, F, Marinescu, C, Ribera, E, Santos, J, Marquez, M, Viciana, I, Palacios, R, Gonzalez, C, Viciana, P, Leal, M, Lopez-Cortes, L, Espinosa, N, Munoz, J, Zubero, M, Baraia-Etxaburu, J, Ibarra, S, Ferrero, O, Lopez de Munain, J, Camara, M, Lopez, I, de la Pena, M, Suarez-Garcia, I, Malmierca, E, Olalla, J, del Arco, A, de la Torre, J, Prada, J, Caracuel, Z, Lopez-Lirola, A, Lozano, A, Fernandez, E, Martinez, O, Vera, F, Martinez, L, Alcaraz, B, Jimeno, A, Poveda, E, Pernas, B, Mena, A, Grandal, M, Castro, A, Pedreira, J, Galera, C, Albendin, H, Iborra, A, Campillo, M, Vidal, A, Amador, C, Pasquau, F, Ena, J, Benito, C, Fenoll, V, Mohamed-Balghata, M, Gomez, M, Alberto de Zarraga, M, Rivas, M, Gorgolas, M, Svedhem-Johansson, V, Flamholc, L, Gisslen, M, Hejdeman, B, Norgren, H, Wendahl, S, Vourli G., Noori T., Pharris A., Porter K., Axelsson M., Begovac J., Cazein F., Costagliola D., Cowan S., Croxford S., Monforte A. D., Delpech V., Diaz A., Girardi E., Gunsenheimer-Bartmeyer B., Hernando V., Leierer G., Lot F., Nunez O., Obel N., Op de Coul E., Paraskeva D., Patrinos S., Reiss P., Schmid D., Sonnerborg A., Suligoi B., Supervie V., van Sighem A., Zangerle R., Touloumi G., Egle A., Kanatschnig M., Ollinger A., Rieger A., Schmied B., Wallner E., Dewasurendra D., Gisinger M., Kitchen M., Plattner A., Rieser E., Sarcletti M., Greil R., Schachner M., Skocic M., Muller M., Aichwalder R., Chromy D., Grabmeier-Pfstershammer K., Skoll M., Touzeau V., Cichon P., Wolf-Nussmuller S., Laferl H., Zoufaly A., Genger-Hackl C., Kapper A., Schneeberger T., Trattner E., Schober G., Atzl M., Hartmann B., Puchhammer-Stockl E., Berg J., Appoyer H., Rappold M., Strickner S., Schindelwig K., Ledergerber B., Fatkenheuer G., Gerstof J., Kronborg G., Pedersen C., Larsen C. S., Pedersen G., Mohey R., Nielsen L., Weise L., Kvinesdal B., Jensen J., Abgrall S., Bernard L., Billaud E., Boue F., Boyer L., Cabie A., Caby F., Canestri A., Cotte L., de Truchis P., Duval X., Duvivier C., Enel P., Fischer H., Gasnault J., Gaud C., Grabar S., Khuong-Josses M. A., Launay O., Marchand L., Mary-Krause M., Matheron S., Melica-Gregoire G., Melliez H., Meynard J. L., Nacher M., Pavie J., Piroth L., Poizot-Martin I., Pradier C., Reynes J., Rouveix E., Simon A., Slama L., Tattevin P., Tissot-Dupont H., Biga J., Kurth T., Jacquemet N., Guiguet M., Leclercq S., Lievre L., Marshall E., Roul H., Selinger-Leneman H., Potard V., Benveniste O., Breton G., Lupin C., Bourzam E., Girard P. M., Fonquernie L., Valin N., Lefebvre B., Sebire M., Pialoux G., Lebrette M. G., Tibaut P., Adda A., Hamidi M., Cadranel J., Lavole A., Parrot A., Bouchaud O., Vignier N., Mechai F., Makhlouf S., Honore P., Bergmann J. F., Delcey V., Lopes A., Sellier P., Parrinello M., Oksenhendler E., Gerard L., Molina J. M., Rozenbaum W., Denis B., De Castro N., Lascoux C., Yazdanpanah Y., Lariven S., Joly V., Rioux C., Poupard M., Taverne B., Sutton L., Masse V., Genet P., Wifaq B., Gerbe J., Grefe S., Dupont C., Freire Maresca A., Reimann E., Bloch M., Meier F., Mortier E., Zeng F., Montoya B., Perronne C., Mathez D., Marigot-Outtandy D., Berthe H., Greder Belan A., Terby A., Godin Collet C., Marque Juillet S., Ruquet M., Roussin-Bretagne S., Colardelle P., Granier F., Laurichesse J. J., Perronne V., Akpan T., Marcou M., Daneluzzi V., Veyssier-Belot C., Masson H., Welker Y., Brazille P., Kahn J. E., Zucman D., Majerholc C., Fourn E., Bornarel D., Chambrin V., Kansau I., Raho-Moussa M., Lelievre J. D., Saidani M., Chesnel C., Dumont C., Vittecoq D., Derradji O., Bolliot C., Goujard C., Teicher E., Mole M., Bourdic K., Salmon D., Le Jeunne C., Guet P., Pietri M. P., Pannier Metzger E., Marcou V., Loulergue P., Dupin N., Morini J. P., Deleuze J., Gerhardt P., Chanal J., Weiss L., Lucas M. L., Jung C., Ptak M., Viard J. P., Ghosn J., Gazalet P., Cros A., Maignan A., Lortholary O., Rouzaud C., Touam F., Benhadj K., Consigny P. H., Bossi P., Gergely A., Cessot G., Durand F., Beck-Wirth G., Michel C., Benomar M., Rey D., Partisani M., Cheneau C., Batard M. L., Fischer P., Leclercq P., Blanc M., Morand P., Epaulard O., Signori-Schmuck A., Laurichesse H., Jacomet C., Vidal M., Coban D., Casanova S., Fresard A., Guglielminotti C., Botelho-Nevers E., Brunon-Gagneux A., Ronat V., Verdon R., Dargere S., Haustraete E., Feret P., Goubin P., Chavanet P., Fillion A., Croisier D., Gohier S., Arvieux C., Souala F., Chapplain J. M., Ratajczak M., Rohan J., Faller J. P., Ruyer O., Gendrin V., Toko L., Chirouze C., Hustache-Mathieu L., Faucher J. F., Proust A., Magy-Bertrand N., Gil H., Meaux-Ruault N., Sotto A., Rouanet I., Mauboussin J. 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R., Cicalini S., Cingolani A., Cinque P., Di Biagio A., Gianotti N., Gori A., Guaraldi G., Lapadula G., Lichtner M., Madeddu G., Maggiolo F., Marchetti G., Monno L., Nozza S., Pinnetti C., Quiros Roldan E., Rossotti R., Rusconi S., Santoro M. M., Saracino A., Sarmati L., Fanti I., Galli L., Lorenzini P., Rodano A., Macchia M., Tavelli A., Carletti F., Carrara S., Di Caro A., Graziano S., Petroni F., Prota G., Trufa S., Giacometti A., Costantini A., Barocci V., Angarano G., Milano E., Suardi C., Donati V., Verucchi G., Castelnuovo F., Minardi C., Menzaghi B., Abeli C., Cacopardo B., Celesia B., Vecchiet J., Falasca K., Pan A., Lorenzotti S., Sighinolf L., Segala D., Blanc P., Vichi F., Cassola G., Viscoli C., Alessandrini A., Bobbio N., Mazzarello G., Fondaco L., Bonfanti P., Molteni C., Chiodera A., Milini P., Nunnari G., Pellicano G., Rizzardini G., Cannizzo E. S., Moioli M. C., Piolini R., Bernacchia D., Salpietro S., Tincati C., Puzzolante C., Migliorino C., Sangiovanni V., Borgia G., Esposito V., Di Flumeri G., Gentile I., Rizzo V., Cattelan A. M., Marinello S., Cascio A., Trizzino M., Francisci D., Schiaroli E., Parruti G., Sozio F., Magnani G., Ursitti M. A., Cristaudo A., Vullo V., Acinapura R., Moschese D., Capozzi M., Mondi A., Rivano Capparuccia M., Iaiani G., Latini A., Gagliardini R., Plazzi M. M., De Girolamo G., Vergori A., Cecchetto M., Viviani F., De Vito A., Rossetti B., Montagnani F., Franco A., Fontana Del Vecchio R., Di Giuli C., Caramello P., Orofno G. C., Sciandra M., Bassetti M., Londero A., Manfrin V., Battagin G., Starnini G., Ialungo A., van der Valk M., Geerlings S. E., Goorhuis A., Hovius J. W., Lempkes B., Nellen F. J. B., van der Poll T., Prins J. M., van Vugt M., Wiersinga W. J., Wit F. W. M. N., van Duinen M., van Eden J., Hazenberg A., van Hes A. M. H., Pijnappel F. J. J., Smalhout S. Y., Weijsenfeld A. M., Jurriaans S., Back N. K. T., Zaaijer H. L., Berkhout B., Cornelissen M. T. E., Schinkel C. J., Wolthers K. C., Peters E. J. G., van Agtmael M. A., Bomers M., Sigalof K. C. E., Heitmuller M., Laan L. M., Ang C. W., van Houdt R., Jonges M., van Prehn J., Kuijpers T. W., Pajkrt D., Scherpbier H. J., de Boer C., van der Plas A., van den Berge M., Stegeman A., Baas S., Hage de Loof L., Wintermans B., Veenemans J., Pronk M. J. H., Ammerlaan H. S. M., de Munnik E. S., Jansz A. R., Tjhie J., Wegdam M. C. A., Deiman B., Scharnhorst V., van Eeden A., Brokking W., Elsenburg L. J. M., Nobel H., Damen M., van Kasteren M. E. E., Berrevoets M. A. H., Brouwer A. E., Adams A., de Kruijf-Van de Wiel B. A. F. M., Keelan-Pfaf S., van der Ven B., Buiting A. G. M., Murck J. L., Versteeg D., de Vries-Sluijs T. E. M. S., Bax H. I., van Gorp E. C. M., Nouwen J. L., Rijnders B. J. A., Schurink C. A. M., Verbon A., de Jong-Peltenburg N. C., Bassant N., van Beek J. E. A., Vriesde M., van Zonneveld L. 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P., Burgers K., Schippers J., Weijenberg-Maes B., van Loo I. H. M., Havenith T. R. A., Weijer S., van Vonderen M. G. A., Kampschreur L. M., Faber S., Steeman-Bouma R., Weel J., Kootstra G. J., Delsing C. E., van der Burg-Van de Plas M., Heins H., Kortmann W., van Twillert G., Renckens R., Ruiter-Pronk D., van Truijen-Oud F. A., Cohen Stuart J. W. T., Jansen E. R., Hoogewerf M., Rozemeijer W., van der Reijden W. A., Sinnige J. C., Brinkman K., van den Berk G. E. L., Blok W. L., Frissen P. H. J., Lettinga K. D., Schouten W. E. M., Veenstra J., Vrouenraets S. M. E., Brouwer C. J., Geerders G. F., Hoeksema K., Kleene M. J., Knapen M., van der Meche I. B., Mulder-Seeleman E., Toonen A. J. M., Wijnands S., Kwa D., van Crevel R., van Aerde K., Doferhof A. S. M., Henriet S. S. V., ter Hofstede H. J. M., Hoogerwerf J., Keuter M., Richel O., Albers M., Grintjes-Huisman K. J. T., de Haan M., Marneef M., Strik-Albers R., Rahamat-Langendoen J., Stelma F. F., Burger D., Gisolf E. H., Hassing R. 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O., van Sighem A. I., Smit C., Hillebregt M., de Jong A., Woudstra T., Bergsma D., Meijering R., van de Sande L., Rutkens T., van der Vliet S., de Groot L., van den Akker M., Bakker Y., El Berkaoui A., Bezemer M., Bretin N., Djoechro E., Geerlinks J., Kruijne E., Lodewijk C., Lucas E., van der Meer R., Munjishvili L., Paling F., Peeck B., Ree C., Regtop R., Ruijs Y., Schoorl M., Schnorr P., Tuijn E., Veenenberg L., Witte E. C., Tuk B., Moreno S., del Amo J., Dalmau D., Navarro M. L., Gonzalez M. I., Blanco J. L., Garcia F., Rubio R., Iribarren J. A., Gutierrez F., Vidal F., Berenguer J., Gonzalez J., Sobrino P., Alejos B., Alvarez D., Jarrin I., Moreno C., Munoz-Fernandez M. A., Garcia-Merino I., Rico C. G., de la Fuente J. G., Torre A. G., Portilla J., Merino E., Reus S., Boix V., Giner L., Gadea C., Portilla I., Pampliega M., Diez M., Rodriguez J. C., Sanchez-Paya J., Podzamczer D., Imaz E. F. A., Van Den Eyncle E., Di Yacovo S., Sumoy M., Gomez J. L., Hernandez J., Aleman M. 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J., Martinez L., Garcia J., Alcaraz B., Jimeno A., Poveda E., Pernas B., Mena A., Grandal M., Castro A., Pedreira J. D., Galera C., Albendin H., Iborra A., Campillo M. A., Vidal A., Amador C., Pasquau F., Ena J., Benito C., Fenoll V., Mohamed-Balghata M. O., Gomez M. A., Alberto de Zarraga M., Rivas M. E., Gorgolas M., Svedhem-Johansson V., Flamholc L., Gisslen M., Hejdeman B., Norgren H., and Wendahl S.

Abstract

Background. High uptake of antiretroviral treatment (ART) is essential to reduce human immunodeficiency virus (HIV) transmission and related mortality; however, gaps in care exist. We aimed to construct the continuum of HIV care (CoC) in 2016 in 11 European Union (EU) countries, overall and by key population and sex. To estimate progress toward the Joint United Nations Programme on HIV/AIDS (UNAIDS) 90-90-90 target, we compared 2016 to 2013 estimates for the same countries, representing 73% of the population in the region. Methods. A CoC with the following 4 stages was constructed: number of people living with HIV (PLHIV); proportion of PLHIV diagnosed; proportion of those diagnosed who ever initiated ART; and proportion of those ever treated who achieved viral suppression at their last visit. Results. We estimated that 87% of PLHIV were diagnosed; 92% of those diagnosed had ever initiated ART; and 91% of those ever on ART, or 73% of all PLHIV, were virally suppressed. Corresponding figures for men having sex with men were: 86%, 93%, 93%, 74%; for people who inject drugs: 94%, 88%, 85%, 70%; and for heterosexuals: 86%, 92%, 91%, 72%. The proportion suppressed of all PLHIV ranged from 59% to 86% across countries. Conclusions. The EU is close to the 90-90-90 target and achieved the UNAIDS target of 73% of all PLHIV virally suppressed, significant progress since 2013 when 60% of all PLHIV were virally suppressed. Strengthening of testing programs and treatment support, along with prevention interventions, are needed to achieve HIV epidemic control.

Published
2020

46. Human Immunodeficiency Virus Continuum of Care in 11 European Union Countries at the End of 2016 Overall and by Key Population: Have We Made Progress?

Author

Vourli, G., Noori, T., Pharris, A., Porter, K., Axelsson, M., Begovac, J., Cazein, F., Costagliola, D., Cowan, S., Croxford, S., Monforte, A. D., Delpech, V., Diaz, A., Girardi, E., Gunsenheimer-Bartmeyer, B., Hernando, V., Leierer, G., Lot, F., Nunez, O., Obel, N., Op de Coul, E., Paraskeva, D., Patrinos, S., Reiss, P., Schmid, D., Sonnerborg, A., Suligoi, B., Supervie, V., van Sighem, A., Zangerle, R., Touloumi, G., Egle, A., Kanatschnig, M., Ollinger, A., Rieger, A., Schmied, B., Wallner, E., Dewasurendra, D., Gisinger, M., Kitchen, M., Plattner, A., Rieser, E., Sarcletti, M., Greil, R., Schachner, M., Skocic, M., Muller, M., Aichwalder, R., Chromy, D., Grabmeier-Pfstershammer, K., Skoll, M., Touzeau, V., Cichon, P., Wolf-Nussmuller, S., Laferl, H., Zoufaly, A., Genger-Hackl, C., Kapper, A., Schneeberger, T., Trattner, E., Schober, G., Atzl, M., Hartmann, B., Puchhammer-Stockl, E., Berg, J., Appoyer, H., Rappold, M., Strickner, S., Schindelwig, K., Ledergerber, B., Fatkenheuer, G., Gerstof, J., Kronborg, G., Pedersen, C., Larsen, C. S., Pedersen, G., Mohey, R., Nielsen, L., Weise, L., Kvinesdal, B., Jensen, J., Abgrall, S., Bernard, L., Billaud, E., Boue, F., Boyer, L., Cabie, A., Caby, F., Canestri, A., Cotte, L., de Truchis, P., Duval, X., Duvivier, C., Enel, P., Fischer, H., Gasnault, J., Gaud, C., Grabar, S., Khuong-Josses, M. A., Launay, O., Marchand, L., Mary-Krause, M., Matheron, S., Melica-Gregoire, G., Melliez, H., Meynard, J. L., Nacher, M., Pavie, J., Piroth, L., Poizot-Martin, I., Pradier, C., Reynes, J., Rouveix, E., Simon, A., Slama, L., Tattevin, P., Tissot-Dupont, H., Biga, J., Kurth, T., Jacquemet, N., Guiguet, M., Leclercq, S., Lievre, L., Marshall, E., Roul, H., Selinger-Leneman, H., Potard, V., Benveniste, O., Breton, G., Lupin, C., Bourzam, E., Girard, P. M., Fonquernie, L., Valin, N., Lefebvre, B., Sebire, M., Pialoux, G., Lebrette, M. G., Tibaut, P., Adda, A., Hamidi, M., Cadranel, J., Lavole, A., Parrot, A., Bouchaud, O., Vignier, N., Mechai, F., Makhlouf, S., Honore, P., Bergmann, J. F., Delcey, V., Lopes, A., Sellier, P., Parrinello, M., Oksenhendler, E., Gerard, L., Molina, J. M., Rozenbaum, W., Denis, B., De Castro, N., Lascoux, C., Yazdanpanah, Y., Lariven, S., Joly, V., Rioux, C., Poupard, M., Taverne, B., Sutton, L., Masse, V., Genet, P., Wifaq, B., Gerbe, J., Grefe, S., Dupont, C., Freire Maresca, A., Reimann, E., Bloch, M., Meier, F., Mortier, E., Zeng, F., Montoya, B., Perronne, C., Mathez, D., Marigot-Outtandy, D., Berthe, H., Greder Belan, A., Terby, A., Godin Collet, C., Marque Juillet, S., Ruquet, M., Roussin-Bretagne, S., Colardelle, P., Granier, F., Laurichesse, J. J., Perronne, V., Akpan, T., Marcou, M., Daneluzzi, V., Veyssier-Belot, C., Masson, H., Welker, Y., Brazille, P., Kahn, J. E., Zucman, D., Majerholc, C., Fourn, E., Bornarel, D., Chambrin, V., Kansau, I., Raho-Moussa, M., Lelievre, J. D., Saidani, M., Chesnel, C., Dumont, C., Vittecoq, D., Derradji, O., Bolliot, C., Goujard, C., Teicher, E., Mole, M., Bourdic, K., Salmon, D., Le Jeunne, C., Guet, P., Pietri, M. P., Pannier Metzger, E., Marcou, V., Loulergue, P., Dupin, N., Morini, J. P., Deleuze, J., Gerhardt, P., Chanal, J., Weiss, L., Lucas, M. L., Jung, C., Ptak, M., Viard, J. P., Ghosn, J., Gazalet, P., Cros, A., Maignan, A., Lortholary, O., Rouzaud, C., Touam, F., Benhadj, K., Consigny, P. H., Bossi, P., Gergely, A., Cessot, G., Durand, F., Beck-Wirth, G., Michel, C., Benomar, M., Rey, D., Partisani, M., Cheneau, C., Batard, M. 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M., Makhlouf, D., Brunel, F., Chiarello, P., Hoen, B., Lamaury, I., Fabre, I., Samar, K., Duvallon, E., Clavel, C., Stegmann, S., Walter, V., Adriouch, L., Huber, F., Vanticlke, V., Couppie, P., Abel, S., Pierre-Francois, S., Ricaud, C., Rodet, R., Wartel, G., Sautron, C., Poubeau, P., Borgherini, G., Camuset, G., Arasteh, K., Kowohl Vivantes, S., Schurmann, D., Warncke Charite, M., Rockstroh, J., Wasmuth, J., Hass, S., Jensen, B. O., Feind, C., Esser, S., Schenk-Westkamp, P., Haberl, A., Stephan, C., Plettenberg, A., Kuhlendahl, F., Adam, A., Weitner, L., Schewe, K., Goey, H., Fenske, S., Buhk, T., Stellbrink, H. J., Hofmann, C., Hansen, S., Degen, O., Heuer, M., Stoll, M., Gerschmann, S., Horst, H., Trautmann, S., Gillor, D., Bogner, J., Sonntag, B., Salzberger, B., Fritzsche, C., Adamis, G., Antoniadou, A., Chini, M., Chrysos, G., Gikas, A., Gogos, H. A., Katsarou, O., Lazanas, M., Metallidis, S., Panagopoulos, P., Paparizos, V., Papastamopoulos, V., Paraskevis, D., Psychogiou, M., Sambatakou, H., Sipsas, N. V., Pantazis, N., Papadopoulos, A., Nitsotolis, T., Xylomenos, G., Marangos, M. N., Kouramba, A., Kontos, A., Lioni, A., Tsachouridou, O., Kourkounti, S., Ganitis, A., Barbounakis, E., d'Arminio Monforte, A., Antinori, A., Andreoni, M., Castagna, A., Castelli, F., Cauda, R., Di Perri, G., Galli, M., Iardino, R., Ippolito, G., Lazzarin, A., Marchetti, G. C., Rezza, G., von Schloesser, F., Viale, P., Ceccherini-Silberstein, F., Cozzi-Lepri, A., Lo Caputo, S., Mussini, C., Puoti, M., Perno, C. F., Bai, F., Balotta, C., Bandera, A., Bonora, S., Borderi, M., Calcagno, A., Capetti, A., Capobianchi, M. R., Cicalini, S., Cingolani, A., Cinque, P., Di Biagio, A., Gianotti, N., Gori, A., Guaraldi, G., Lapadula, G., Lichtner, M., Madeddu, G., Maggiolo, F., Marchetti, G., Monno, L., Nozza, S., Pinnetti, C., Quiros Roldan, E., Rossotti, R., Rusconi, S., Santoro, M. M., Saracino, A., Sarmati, L., Fanti, I., Galli, L., Lorenzini, P., Rodano, A., Macchia, M., Tavelli, A., Carletti, F., Carrara, S., Di Caro, A., Graziano, S., Petroni, F., Prota, G., Trufa, S., Giacometti, A., Costantini, A., Barocci, V., Angarano, G., Milano, E., Suardi, C., Donati, V., Verucchi, G., Castelnuovo, F., Minardi, C., Menzaghi, B., Abeli, C., Cacopardo, B., Celesia, B., Vecchiet, J., Falasca, K., Pan, A., Lorenzotti, S., Sighinolf, L., Segala, D., Blanc, P., Vichi, F., Cassola, G., Viscoli, C., Alessandrini, A., Bobbio, N., Mazzarello, G., Fondaco, L., Bonfanti, P., Molteni, C., Chiodera, A., Milini, P., Nunnari, G., Pellicano, G., Rizzardini, G., Cannizzo, E. S., Moioli, M. 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V., Smit, E., Struik-Kalkman, D., Tearno, C., van Niekerk, T., Pontesilli, O., Lowe, S. H., Oude Lashof, A. M. L., Posthouwer, D., Ackens, R. P., Burgers, K., Schippers, J., Weijenberg-Maes, B., van Loo, I. H. M., Havenith, T. R. A., Weijer, S., van Vonderen, M. G. A., Kampschreur, L. M., Faber, S., Steeman-Bouma, R., Weel, J., Kootstra, G. J., Delsing, C. E., van der Burg-Van de Plas, M., Heins, H., Kortmann, W., van Twillert, G., Renckens, R., Ruiter-Pronk, D., van Truijen-Oud, F. A., Cohen Stuart, J. W. T., Jansen, E. R., Hoogewerf, M., Rozemeijer, W., van der Reijden, W. A., Sinnige, J. C., Brinkman, K., van den Berk, G. E. L., Blok, W. L., Frissen, P. H. J., Lettinga, K. D., Schouten, W. E. M., Veenstra, J., Vrouenraets, S. M. E., Brouwer, C. J., Geerders, G. F., Hoeksema, K., Kleene, M. J., Knapen, M., van der Meche, I. B., Mulder-Seeleman, E., Toonen, A. J. M., Wijnands, S., Kwa, D., van Crevel, R., van Aerde, K., Doferhof, A. S. M., Henriet, S. S. V., ter Hofstede, H. J. M., Hoogerwerf, J., Keuter, M., Richel, O., Albers, M., Grintjes-Huisman, K. J. T., de Haan, M., Marneef, M., Strik-Albers, R., Rahamat-Langendoen, J., Stelma, F. F., Burger, D., Gisolf, E. H., Hassing, R. J., Claassen, M., ter Beest, G., van Bentum, P. H. M., Langebeek, N., Tiemessen, R., Swanink, C. M. A., van Lelyveld, S. F. L., Soetekouw, R., van der Prijt, L. M. M., van der Swaluw, J., Bermon, N., Jansen, R., Herpers, B. L., Veenendaal, D., Verhagen, D. W. M., Lauw, F. N., van Broekhuizen, M. C., van Wijk, M., Bierman, W. F. W., Bakker, M., Kleinnijenhuis, J., Kloeze, E., Middel, A., Scholvinck, E. H., Stienstra, Y., Verhage, A. R., Wouthuyzen-Bakker, K. M., Boonstra, A., de Groot-De Jonge, H., van der Meulen, P. A., de Weerd, D. A., Niesters, H. G. M., van Leer-Buter, C. C., Knoester, M., Hoepelman, A. I. M., Arends, J. E., Barth, R. E., Bruns, A. H. W., Ellerbroek, P. M., Mudrikova, T., Oosterheert, J. J., de Regt, M. J. A., Schadd, E. M., van Zoelen, M. A. 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E., Gorgolas, M., Svedhem-Johansson, V., Flamholc, L., Gisslen, M., Hejdeman, B., Norgren, H., Wendahl, S., European Centre for Disease Prevention and Control (ECDC), Esser, Stefan (Beitragende*r), Schenk-Westkamp, Pia (Herausgeber*in), Vourli G., Noori T., Pharris A., Porter K., Axelsson M., Begovac J., Cazein F., Costagliola D., Cowan S., Croxford S., Monforte A.D., Delpech V., Diaz A., Girardi E., Gunsenheimer-Bartmeyer B., Hernando V., Leierer G., Lot F., Nunez O., Obel N., Op de Coul E., Paraskeva D., Patrinos S., Reiss P., Schmid D., Sonnerborg A., Suligoi B., Supervie V., van Sighem A., Zangerle R., Touloumi G., Egle A., Kanatschnig M., Ollinger A., Rieger A., Schmied B., Wallner E., Dewasurendra D., Gisinger M., Kitchen M., Plattner A., Rieser E., Sarcletti M., Greil R., Schachner M., Skocic M., Muller M., Aichwalder R., Chromy D., Grabmeier-Pfstershammer K., Skoll M., Touzeau V., Cichon P., Wolf-Nussmuller S., Laferl H., Zoufaly A., Genger-Hackl C., Kapper A., Schneeberger T., Trattner E., Schober G., Atzl M., Hartmann B., Puchhammer-Stockl E., Berg J., Appoyer H., Rappold M., Strickner S., Schindelwig K., Ledergerber B., Fatkenheuer G., Gerstof J., Kronborg G., Pedersen C., Larsen C.S., Pedersen G., Mohey R., Nielsen L., Weise L., Kvinesdal B., Jensen J., Abgrall S., Bernard L., Billaud E., Boue F., Boyer L., Cabie A., Caby F., Canestri A., Cotte L., de Truchis P., Duval X., Duvivier C., Enel P., Fischer H., Gasnault J., Gaud C., Grabar S., Khuong-Josses M.A., Launay O., Marchand L., Mary-Krause M., Matheron S., Melica-Gregoire G., Melliez H., Meynard J.L., Nacher M., Pavie J., Piroth L., Poizot-Martin I., Pradier C., Reynes J., Rouveix E., Simon A., Slama L., Tattevin P., Tissot-Dupont H., Biga J., Kurth T., Jacquemet N., Guiguet M., Leclercq S., Lievre L., Marshall E., Roul H., Selinger-Leneman H., Potard V., Benveniste O., Breton G., Lupin C., Bourzam E., Girard P.M., Fonquernie L., Valin N., Lefebvre B., Sebire M., Pialoux G., Lebrette M.G., Tibaut P., Adda A., Hamidi M., Cadranel J., Lavole A., Parrot A., Bouchaud O., Vignier N., Mechai F., Makhlouf S., Honore P., Bergmann J.F., Delcey V., Lopes A., Sellier P., Parrinello M., Oksenhendler E., Gerard L., Molina J.M., Rozenbaum W., Denis B., De Castro N., Lascoux C., Yazdanpanah Y., Lariven S., Joly V., Rioux C., Poupard M., Taverne B., Sutton L., Masse V., Genet P., Wifaq B., Gerbe J., Grefe S., Dupont C., Freire Maresca A., Reimann E., Bloch M., Meier F., Mortier E., Zeng F., Montoya B., Perronne C., Mathez D., Marigot-Outtandy D., Berthe H., Greder Belan A., Terby A., Godin Collet C., Marque Juillet S., Ruquet M., Roussin-Bretagne S., Colardelle P., Granier F., Laurichesse J.J., Perronne V., Akpan T., Marcou M., Daneluzzi V., Veyssier-Belot C., Masson H., Welker Y., Brazille P., Kahn J.E., Zucman D., Majerholc C., Fourn E., Bornarel D., Chambrin V., Kansau I., Raho-Moussa M., Lelievre J.D., Saidani M., Chesnel C., Dumont C., Vittecoq D., Derradji O., Bolliot C., Goujard C., Teicher E., Mole M., Bourdic K., Salmon D., Le Jeunne C., Guet P., Pietri M.P., Pannier Metzger E., Marcou V., Loulergue P., Dupin N., Morini J.P., Deleuze J., Gerhardt P., Chanal J., Weiss L., Lucas M.L., Jung C., Ptak M., Viard J.P., Ghosn J., Gazalet P., Cros A., Maignan A., Lortholary O., Rouzaud C., Touam F., Benhadj K., Consigny P.H., Bossi P., Gergely A., Cessot G., Durand F., Beck-Wirth G., Michel C., Benomar M., Rey D., Partisani M., Cheneau C., Batard M.L., Fischer P., Leclercq P., Blanc M., Morand P., Epaulard O., Signori-Schmuck A., Laurichesse H., Jacomet C., Vidal M., Coban D., Casanova S., Fresard A., Guglielminotti C., Botelho-Nevers E., Brunon-Gagneux A., Ronat V., Verdon R., Dargere S., Haustraete E., Feret P., Goubin P., Chavanet P., Fillion A., Croisier D., Gohier S., Arvieux C., Souala F., Chapplain J.M., Ratajczak M., Rohan J., Faller J.P., Ruyer O., Gendrin V., Toko L., Chirouze C., Hustache-Mathieu L., Faucher J.F., Proust A., Magy-Bertrand N., Gil H., Meaux-Ruault N., Sotto A., Rouanet I., Mauboussin J.M., Doncesco R., Jacques G., May T., Rabaud C., Andre M., Delestan M., Bouillon M.P., Bani-Sadr F., Rouger C., Berger J.L., Nguyen Y., Marchou B., Delobel P., Martin Blondel G., Cuzin L., Biezunski N., Alric L., Bonnet D., Guivarch M., Palacin A., Payssan V., Ajana F., Meybeck A., Viget N., Pugliese P., Roger P.M., Rosenthal E., Durant J., Cua E., Naqvi A., Perbost I., Risso K., Quinsat D., Raphael St., Del Giudice P., Dides P.Y., Sambuc R., Antolini-Bouvenot M.S., Druart P., Meddeb L., Ravaux I., Menard A., Tomei C., Dhiver C., Moreau J., Mokhtari S., Soavi M.J., Tomas V., Bregigeon S., Faucher O., Obry-Roguet V., Ritleng A.S., Petit N., Bartoli C., Ruiz J.M., Blanc D., Allegre T., Sordage M., Riou J.M., Faudon C., Slama B., Zerazhi H., Boulat O., Chebrek S., Beyrne M., Granet Brunello P., Pellissier L., Bonnabel D., Cohen Valensi R., Mouchet B., Mboungou G., Lafeuillade A., Hope-Rapp E., Hittinger G., Philip G., Lambry V., Raf F., Allavena C., Hall N., Reliquet V., Chidiac C., Ferry T., Perpoint T., Miailhes P., Boibieux A., Livrozet J.M., Makhlouf D., Brunel F., Chiarello P., Hoen B., Lamaury I., Fabre I., Samar K., Duvallon E., Clavel C., Stegmann S., Walter V., Adriouch L., Huber F., Vanticlke V., Couppie P., Abel S., Pierre-Francois S., Ricaud C., Rodet R., Wartel G., Sautron C., Poubeau P., Borgherini G., Camuset G., Arasteh K., Kowohl Vivantes S., Schurmann D., Warncke Charite M., Rockstroh J., Wasmuth J., Hass S., Jensen B.O., Feind C., Esser S., Schenk-Westkamp P., Haberl A., Stephan C., Plettenberg A., Kuhlendahl F., Adam A., Weitner L., Schewe K., Goey H., Fenske S., Buhk T., Stellbrink H.J., Hofmann C., Hansen S., Degen O., Heuer M., Stoll M., Gerschmann S., Horst H., Trautmann S., Gillor D., Bogner J., Sonntag B., Salzberger B., Fritzsche C., Adamis G., Antoniadou A., Chini M., Chrysos G., Gikas A., Gogos H.A., Katsarou O., Lazanas M., Metallidis S., Panagopoulos P., Paparizos V., Papastamopoulos V., Paraskevis D., Psychogiou M., Sambatakou H., Sipsas N.V., Pantazis N., Papadopoulos A., Nitsotolis T., Xylomenos G., Marangos M.N., Kouramba A., Kontos A., Lioni A., Tsachouridou O., Kourkounti S., Ganitis A., Barbounakis E., d'Arminio Monforte A., Antinori A., Andreoni M., Castagna A., Castelli F., Cauda R., Di Perri G., Galli M., Iardino R., Ippolito G., Lazzarin A., Marchetti G.C., Rezza G., von Schloesser F., Viale P., Ceccherini-Silberstein F., Cozzi-Lepri A., Lo Caputo S., Mussini C., Puoti M., Perno C.F., Bai F., Balotta C., Bandera A., Bonora S., Borderi M., Calcagno A., Capetti A., Capobianchi M.R., Cicalini S., Cingolani A., Cinque P., Di Biagio A., Gianotti N., Gori A., Guaraldi G., Lapadula G., Lichtner M., Madeddu G., Maggiolo F., Marchetti G., Monno L., Nozza S., Pinnetti C., Quiros Roldan E., Rossotti R., Rusconi S., Santoro M.M., Saracino A., Sarmati L., Fanti I., Galli L., Lorenzini P., Rodano A., Macchia M., Tavelli A., Carletti F., Carrara S., Di Caro A., Graziano S., Petroni F., Prota G., Trufa S., Giacometti A., Costantini A., Barocci V., Angarano G., Milano E., Suardi C., Donati V., Verucchi G., Castelnuovo F., Minardi C., Menzaghi B., Abeli C., Cacopardo B., Celesia B., Vecchiet J., Falasca K., Pan A., Lorenzotti S., Sighinolf L., Segala D., Blanc P., Vichi F., Cassola G., Viscoli C., Alessandrini A., Bobbio N., Mazzarello G., Fondaco L., Bonfanti P., Molteni C., Chiodera A., Milini P., Nunnari G., Pellicano G., Rizzardini G., Cannizzo E.S., Moioli M.C., Piolini R., Bernacchia D., Salpietro S., Tincati C., Puzzolante C., Migliorino C., Sangiovanni V., Borgia G., Esposito V., Di Flumeri G., Gentile I., Rizzo V., Cattelan A.M., Marinello S., Cascio A., Trizzino M., Francisci D., Schiaroli E., Parruti G., Sozio F., Magnani G., Ursitti M.A., Cristaudo A., Vullo V., Acinapura R., Moschese D., Capozzi M., Mondi A., Rivano Capparuccia M., Iaiani G., Latini A., Gagliardini R., Plazzi M.M., De Girolamo G., Vergori A., Cecchetto M., Viviani F., De Vito A., Rossetti 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Pedreira J.D., Galera C., Albendin H., Iborra A., Campillo M.A., Vidal A., Amador C., Pasquau F., Ena J., Benito C., Fenoll V., Mohamed-Balghata M.O., Gomez M.A., Alberto de Zarraga M., Rivas M.E., Gorgolas M., Svedhem-Johansson V., Flamholc L., Gisslen M., Hejdeman B., Norgren H., Wendahl S., Global Health, Infectious diseases, AII - Infectious diseases, APH - Aging & Later Life, ANS - Neuroinfection & -inflammation, Internal medicine, Medical Microbiology and Infection Prevention, AMS - Rehabilitation & Development, VU University medical center, Amsterdam Gastroenterology Endocrinology Metabolism, Pediatric surgery, Neurology, Amsterdam Neuroscience - Neurodegeneration, Pulmonary medicine, Psychiatry, APH - Mental Health, Amsterdam Neuroscience - Complex Trait Genetics, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Ethics, Law & Medical humanities, APH - Quality of Care, ACS - Pulmonary hypertension & thrombosis, Amsterdam Neuroscience - Neuroinfection & -inflammation, Amsterdam Reproduction & Development (AR&D), APH - Societal Participation & Health, Pediatrics, HAL-SU, Gestionnaire, National and Kapodistrian University of Athens (NKUA), University College of London [London] (UCL), Public Health Agency of Sweden, University of Zagreb, Santé publique France - French National Public Health Agency [Saint-Maurice, France], Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Statens Serum Institut [Copenhagen], Public Health England [London], Università degli Studi di Milano = University of Milan (UNIMI), Instituto de Salud Carlos III [Madrid] (ISC), Istituto Nazionale di Malattie Infettive 'Lazzaro Spallanzani' (INMI), Robert Koch Institute [Berlin] (RKI), Innsbruck Medical University = Medizinische Universität Innsbruck (IMU), University of Copenhagen = Københavns Universitet (UCPH), National Institute for Public Health and the Environment [Bilthoven] (RIVM), Hellenic Center for Disease Control and Prevention, Amsterdam UMC - Amsterdam University Medical Center, Austrian Agency for Health and Food Safety (AGES), Department of Infectious Diseases, Institution of Medicine, Karolinska University Hospital and Karolinska Institutet, Istituto Superiore di Sanita [Rome], Stichting HIV Monitoring [Amsterdam], Universiteit van Amsterdam (UvA), University of Athens Medical School [Athens], Vourli, G, Noori, T, Pharris, A, Porter, K, Axelsson, M, Begovac, J, Cazein, F, Costagliola, D, Cowan, S, Croxford, S, Monforte, A, Delpech, V, Diaz, A, Girardi, E, Gunsenheimer-Bartmeyer, B, Hernando, V, Leierer, G, Lot, F, Nunez, O, Obel, N, Op de Coul, E, Paraskeva, D, Patrinos, S, Reiss, P, Schmid, D, Sonnerborg, A, Suligoi, B, Supervie, V, van Sighem, A, Zangerle, R, Touloumi, G, Egle, A, Kanatschnig, M, Ollinger, A, Rieger, A, Schmied, B, Wallner, E, Dewasurendra, D, Gisinger, M, Kitchen, M, Plattner, A, Rieser, E, Sarcletti, 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Subjects
Male, 0301 basic medicine, Psychological intervention, Human immunodeficiency virus (HIV), Medizin, Continuum of care, Europe, HIV infection, Key population, Sex, Anti-Retroviral Agents, Continuity of Patient Care, European Union, HIV, Humans, HIV Infections, medicine.disease_cause, key population, 0302 clinical medicine, HIV Infection, 030212 general & internal medicine, Men having sex with men, media_common, education.field_of_study, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Transmission (medicine), Infectious Diseases, AcademicSubjects/MED00290, HIV infection, continuum of care, sex, key population, Europe, Microbiology (medical), Population, Socio-culturale, 03 medical and health sciences, Acquired immunodeficiency syndrome (AIDS), SDG 3 - Good Health and Well-being, medicine, media_common.cataloged_instance, European union, education, Pandemics, continuum of care, sex, business.industry, SARS-CoV-2, COVID-19, medicine.disease, 030112 virology, Major Articles and Commentaries, Anti-Retroviral Agent, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Demography
Abstract

Background High uptake of antiretroviral treatment (ART) is essential to reduce human immunodeficiency virus (HIV) transmission and related mortality; however, gaps in care exist. We aimed to construct the continuum of HIV care (CoC) in 2016 in 11 European Union (EU) countries, overall and by key population and sex. To estimate progress toward the Joint United Nations Programme on HIV/AIDS (UNAIDS) 90-90-90 target, we compared 2016 to 2013 estimates for the same countries, representing 73% of the population in the region. Methods A CoC with the following 4 stages was constructed: number of people living with HIV (PLHIV); proportion of PLHIV diagnosed; proportion of those diagnosed who ever initiated ART; and proportion of those ever treated who achieved viral suppression at their last visit. Results We estimated that 87% of PLHIV were diagnosed; 92% of those diagnosed had ever initiated ART; and 91% of those ever on ART, or 73% of all PLHIV, were virally suppressed. Corresponding figures for men having sex with men were: 86%, 93%, 93%, 74%; for people who inject drugs: 94%, 88%, 85%, 70%; and for heterosexuals: 86%, 92%, 91%, 72%. The proportion suppressed of all PLHIV ranged from 59% to 86% across countries. Conclusions The EU is close to the 90-90-90 target and achieved the UNAIDS target of 73% of all PLHIV virally suppressed, significant progress since 2013 when 60% of all PLHIV were virally suppressed. Strengthening of testing programs and treatment support, along with prevention interventions, are needed to achieve HIV epidemic control., Standardized definitions were used to estimate a 4-stage continuum of human immunodeficiency virus (HIV) care in 11 European Union (EU) countries in 2016. The EU is close to the 90-90-90 target, with the main challenge being the percentage of undiagnosed infections.

Published
2020
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49. 665: Forskolin-induced intestinal organoid swelling predicts long-term cystic fibrosis disease progression

Author

Muilwijk, D., primary, de Poel, E., additional, van Mourik, P., additional, Suen, S., additional, Vonk, A., additional, Brunsveld, J., additional, Kruisselbrink, E., additional, Oppelaar, H., additional, Hagemeijer, M., additional, Berkers, G., additional, de Winter-de Groot, K., additional, Michel, S., additional, Jans, S., additional, van Panhuis, H., additional, van der Eerden, M., additional, van der Meer, R., additional, Roukema, J., additional, Dompeling, E., additional, Weersink, E., additional, Koppelman, G., additional, Vries, R., additional, Zomer-van Ommen, D., additional, Eijkemans, R., additional, van der Ent, C., additional, and Beekman, J., additional

Published
2021
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50. Financial option valuation by unsupervised learning with artificial neural networks

Author

Salvador, Beatriz (author), Oosterlee, C.W. (author), van der Meer, R. (author), Salvador, Beatriz (author), Oosterlee, C.W. (author), and van der Meer, R. (author)

Abstract

Artificial neural networks (ANNs) have recently also been applied to solve partial differential equations (PDEs). The classical problem of pricing European and American financial options, based on the corresponding PDE formulations, is studied here. Instead of using numerical techniques based on finite element or difference methods, we address the problem using ANNs in the context of unsupervised learning. As a result, the ANN learns the option values for all possible underlying stock values at future time points, based on the minimization of a suitable loss function. For the European option, we solve the linear Black–Scholes equation, whereas for the American option we solve the linear complementarity problem formulation. Two-asset exotic option values are also computed, since ANNs enable the accurate valuation of high-dimensional options. The resulting errors of the ANN approach are assessed by comparing to the analytic option values or to numerical reference solutions (for American options, computed by finite elements). In the short note, previously published, a brief introduction to this work was given, where some ideas to price vanilla options by ANNs were presented, and only European options were addressed. In the current work, the methodology is introduced in much more detail., Numerical Analysis, Electrical Engineering, Mathematics and Computer Science

Published
2021
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