15 results on '"Valley, Matthew T."'
Search Results
2. Responses to pattern-violating visual stimuli evolve differently over days in somata and distal apical dendrites
- Author
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Gillon, Colleen J., primary, Pina, Jason E., additional, Lecoq, Jérôme, additional, Ahmed, Ruweida, additional, Billeh, Yazan N., additional, Caldejon, Shiella, additional, Groblewski, Peter A., additional, Henley, Timothy M., additional, Kato, India, additional, Lee, Eric, additional, Luviano, Jennifer, additional, Mace, Kyla, additional, Nayan, Chelsea, additional, Nguyen, Thuyanh V., additional, North, Kat, additional, Perkins, Jed, additional, Seid, Sam, additional, Valley, Matthew T., additional, Williford, Ali, additional, Bengio, Yoshua, additional, Lillicrap, Timothy P., additional, Richards, Blake A., additional, and Zylberberg, Joel, additional
- Published
- 2023
- Full Text
- View/download PDF
3. Responses to Pattern-Violating Visual Stimuli Evolve Differently Over Days in Somata and Distal Apical Dendrites.
- Author
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Gillon, Colleen J., Pina, Jason E., Lecoq, Jérôme A., Ahmed, Ruweida, Billeh, Yazan N., Caldejon, Shiella, Groblewski, Peter, Henley, Timothy M., Kato, India, Lee, Eric, Luviano, Jennifer, Mace, Kyla, Nayan, Chelsea, Nguyen, Thuyanh V., North, Kat, Perkins, Jed, Seid, Sam, Valley, Matthew T., Williford, Ali, and Bengio, Yoshua
- Subjects
VISUAL perception ,PYRAMIDAL neurons ,VISUAL cortex ,NEOCORTEX ,NEURONS - Abstract
Scientists have long conjectured that the neocortex learns patterns in sensory data to generate top-down predictions of upcoming stimuli. In line with this conjecture, different responses to pattern-matching vs pattern-violating visual stimuli have been observed in both spiking and somatic calcium imaging data. However, it remains unknown whether these pattern-violation signals are different between the distal apical dendrites, which are heavily targeted by top-down signals, and the somata, where bottom-up information is primarily integrated. Furthermore, it is unknown how responses to pattern-violating stimuli evolve over time as an animal gains more experience with them. Here, we address these unanswered questions by analyzing responses of individual somata and dendritic branches of layer 2/3 and layer 5 pyramidal neurons tracked over multiple days in primary visual cortex of awake, behaving female and male mice. We use sequences of Gabor patches with patterns in their orientations to create pattern-matching and pattern-violating stimuli, and two-photon calcium imaging to record neuronal responses. Many neurons in both layers show large differences between their responses to pattern-matching and pattern-violating stimuli. Interestingly, these responses evolve in opposite directions in the somata and distal apical dendrites, with somata becoming less sensitive to pattern-violating stimuli and distal apical dendrites more sensitive. These differences between the somata and distal apical dendrites may be important for hierarchical computation of sensory predictions and learning, since these two compartments tend to receive bottom-up and top-down information, respectively. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
4. A Suite of Transgenic Driver and Reporter Mouse Lines with Enhanced Brain-Cell-Type Targeting and Functionality
- Author
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Daigle, Tanya L., Madisen, Linda, Hage, Travis A., Valley, Matthew T., Knoblich, Ulf, Larsen, Rylan S., Takeno, Marc M., Huang, Lawrence, Gu, Hong, Larsen, Rachael, Mills, Maya, Bosma-Moody, Alice, Siverts, La’ Akea, Walker, Miranda, Graybuck, Lucas T., Yao, Zizhen, Fong, Olivia, Nguyen, Thuc Nghi, Garren, Emma, Lenz, Garreck H., Chavarha, Mariya, Pendergraft, Julie, Harrington, James, Hirokawa, Karla E., Harris, Julie A., Nicovich, Philip R., McGraw, Medea J., Ollerenshaw, Douglas R., Smith, Kimberly A., Baker, Christopher A., Ting, Jonathan T., Sunkin, Susan M., Lecoq, Jérôme, Lin, Michael Z., Boyden, Edward S., Murphy, Gabe J., da Costa, Nuno M., Waters, Jack, Li, Lu, Tasic, Bosiljka, Zeng, Hongkui, Daigle, Tanya L., Madisen, Linda, Hage, Travis A., Valley, Matthew T., Knoblich, Ulf, Larsen, Rylan S., Takeno, Marc M., Huang, Lawrence, Gu, Hong, Larsen, Rachael, Mills, Maya, Bosma-Moody, Alice, Siverts, La’ Akea, Walker, Miranda, Graybuck, Lucas T., Yao, Zizhen, Fong, Olivia, Nguyen, Thuc Nghi, Garren, Emma, Lenz, Garreck H., Chavarha, Mariya, Pendergraft, Julie, Harrington, James, Hirokawa, Karla E., Harris, Julie A., Nicovich, Philip R., McGraw, Medea J., Ollerenshaw, Douglas R., Smith, Kimberly A., Baker, Christopher A., Ting, Jonathan T., Sunkin, Susan M., Lecoq, Jérôme, Lin, Michael Z., Boyden, Edward S., Murphy, Gabe J., da Costa, Nuno M., Waters, Jack, Li, Lu, Tasic, Bosiljka, and Zeng, Hongkui
- Abstract
An expanded toolkit of transgenic mouse lines for exploring the organization, function, and development of mammalian neural circuits.
- Published
- 2022
5. A Suite of Transgenic Driver and Reporter Mouse Lines with Enhanced Brain-Cell-Type Targeting and Functionality
- Author
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Daigle, Tanya L., primary, Madisen, Linda, additional, Hage, Travis A., additional, Valley, Matthew T., additional, Knoblich, Ulf, additional, Larsen, Rylan S., additional, Takeno, Marc M., additional, Huang, Lawrence, additional, Gu, Hong, additional, Larsen, Rachael, additional, Mills, Maya, additional, Bosma-Moody, Alice, additional, Siverts, La’ Akea, additional, Walker, Miranda, additional, Graybuck, Lucas T., additional, Yao, Zizhen, additional, Fong, Olivia, additional, Nguyen, Thuc Nghi, additional, Garren, Emma, additional, Lenz, Garreck H., additional, Chavarha, Mariya, additional, Pendergraft, Julie, additional, Harrington, James, additional, Hirokawa, Karla E., additional, Harris, Julie A., additional, Nicovich, Philip R., additional, McGraw, Medea J., additional, Ollerenshaw, Douglas R., additional, Smith, Kimberly A., additional, Baker, Christopher A., additional, Ting, Jonathan T., additional, Sunkin, Susan M., additional, Lecoq, Jérôme, additional, Lin, Michael Z., additional, Boyden, Edward S., additional, Murphy, Gabe J., additional, da Costa, Nuno M., additional, Waters, Jack, additional, Li, Lu, additional, Tasic, Bosiljka, additional, and Zeng, Hongkui, additional
- Published
- 2018
- Full Text
- View/download PDF
6. Aberrant Cortical Activity in Multiple GCaMP6-Expressing Transgenic Mouse Lines
- Author
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Steinmetz, Nicholas A., primary, Buetfering, Christina, additional, Lecoq, Jerome, additional, Lee, Christian R., additional, Peters, Andrew J., additional, Jacobs, Elina A. K., additional, Coen, Philip, additional, Ollerenshaw, Douglas R., additional, Valley, Matthew T., additional, de Vries, Saskia E. J., additional, Garrett, Marina, additional, Zhuang, Jun, additional, Groblewski, Peter A., additional, Manavi, Sahar, additional, Miles, Jesse, additional, White, Casey, additional, Lee, Eric, additional, Griffin, Fiona, additional, Larkin, Joshua D., additional, Roll, Kate, additional, Cross, Sissy, additional, Nguyen, Thuyanh V., additional, Larsen, Rachael, additional, Pendergraft, Julie, additional, Daigle, Tanya, additional, Tasic, Bosiljka, additional, Thompson, Carol L., additional, Waters, Jack, additional, Olsen, Shawn, additional, Margolis, David J., additional, Zeng, Hongkui, additional, Hausser, Michael, additional, Carandini, Matteo, additional, and Harris, Kenneth D., additional
- Published
- 2017
- Full Text
- View/download PDF
7. Persistent Structural Plasticity Optimizes Sensory Information Processing in the Olfactory Bulb
- Author
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Sailor, Kurt A., primary, Valley, Matthew T., additional, Wiechert, Martin T., additional, Riecke, Hermann, additional, Sun, Gerald J., additional, Adams, Wayne, additional, Dennis, James C., additional, Sharafi, Shirin, additional, Ming, Guo-li, additional, Song, Hongjun, additional, and Lledo, Pierre-Marie, additional
- Published
- 2016
- Full Text
- View/download PDF
8. GABAB Receptors Tune Cortical Feedback to the Olfactory Bulb.
- Author
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Mazo, Camille, Lepousez, Gabriel, Nissant, Antoine, Valley, Matthew T., and Lledo, Pierre-Marie
- Subjects
OLFACTORY bulb ,LIMBIC system ,SENSORY perception ,BRAIN ,GABA receptors - Abstract
Sensory perception emerges from the confluence of sensory inputs that encode the composition of external environment and top-down feedback that conveys information from higher brain centers. In olfaction, sensory input activity is initially processed in the olfactory bulb (OB), serving as the first central relay before being transferred to the olfactory cortex. In addition, the OB receives dense connectivity from feedback projections, so the OB has the capacity to implement a wide array of sensory neuronal computation. However, little is known about the impact and the regulation of this cortical feedback. Here, we describe a novel mechanism to gate glutamatergic feedback selectively from the anterior olfactory cortex (AOC) to the OB. Combining in vitro and in vivo electrophysiological recordings, optoge- netics, and fiber-photometry-based calcium imaging applied to wild-type and conditional transgenic mice, we explore the functional consequences of circuit-specific GABA type-B receptor (GABA
B R) manipulation. We found that activation of presynaptic GABAB Rs specifically depresses synaptic transmission from the AOC to OB inhibitory interneurons, but spares direct excitation to principal neurons. As a consequence, feedforward inhibition of spontaneous and odor-evoked activity of principal neurons is diminished. We also show that tunable cortico-bulbar feedback is critical for generating beta, but not gamma, OB oscillations. Together, these results show that GABAB Rs on cortico-bulbar afferents gate excitatory transmission in a target-specific manner and thus shape how the OB integrates sensory inputs and top-down information. [ABSTRACT FROM AUTHOR]- Published
- 2016
- Full Text
- View/download PDF
9. SRp38 Regulates Alternative Splicing and Is Required for Ca2+ Handling in the Embryonic Heart
- Author
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Feng, Ying, primary, Valley, Matthew T., additional, Lazar, Josef, additional, Yang, Allison L., additional, Bronson, Roderick T., additional, Firestein, Stuart, additional, Coetzee, William A., additional, and Manley, James L., additional
- Published
- 2009
- Full Text
- View/download PDF
10. A Lateral Look at Olfactory Bulb Lateral Inhibition
- Author
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Valley, Matthew T., primary and Firestein, Stuart, additional
- Published
- 2008
- Full Text
- View/download PDF
11. Adult Neurogenesis Produces Neurons with Unique GABAergic Synapses in the Olfactory Bulb.
- Author
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Valley, Matthew T., Henderson, Lansdale G., Inverso, Samuel A., and Lledo, Pierre-Marie
- Subjects
- *
OLFACTORY bulb , *DEVELOPMENTAL neurobiology , *NEURONS , *SYNAPSES , *BRAIN research , *CYTOPLASMIC granules - Abstract
Neuronal regeneration occurs naturally in a few restricted mammalian brain regions, but its functional significance remains debated. Here we search for unique features in the synaptic outputs made by adult-born granule cell interneurons in the mouse olfactory bulb using optogenetic targeting of specific neuronal ages. We find that adult-born interneurons are resistant to presynapticGABAB-mediated depression of GABA release compared with interneurons born just after birth that exhibit strong GABAB neuromodulation. Correlated with this functional change, we found altered localization of the GABABR1 protein within adult-born granule cells. These results suggest that adult neurogenesis produces a population of functionally unique GABAergic synapses in the olfactory bulb. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
12. SRp38 Regulates Alternative Splicing and Is Required for Ca2+ Handling in the Embryonic Heart
- Author
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Feng, Ying, Valley, Matthew T., Lazar, Josef, Yang, Allison L., Bronson, Roderick T., Firestein, Stuart, Coetzee, William A., and Manley, James L.
- Subjects
- *
GENETIC engineering , *REGULATION of heart contraction , *EMBRYOLOGY , *DEVELOPMENTAL cytology , *CALCIUM ions , *LABORATORY mice - Abstract
Summary: SRp38 is an atypical SR protein splicing regulator. To define the functions of SRp38 in vivo, we generated SRp38 null mice. The majority of homozygous mutants survived only until E15.5 and displayed multiple cardiac defects. Evaluation of gene expression profiles in the SRp38−/− embryonic heart revealed a defect in processing of the pre-mRNA encoding cardiac triadin, a protein that functions in regulation of Ca2+ release from the sarcoplasmic reticulum during excitation-contraction coupling. This defect resulted in significantly reduced levels of triadin, as well as those of the interacting protein calsequestrin 2. Purified SRp38 was shown to bind specifically to the regulated exon and to modulate triadin splicing in vitro. Extending these results, isolated SRp38−/− embryonic cardiomyocytes displayed defects in Ca2+ handling compared with wild-type controls. Taken together, our results demonstrate that SRp38 regulates cardiac-specific alternative splicing of triadin pre-mRNA and, reflecting this, is essential for proper Ca2+ handling during embryonic heart development. [Copyright &y& Elsevier]
- Published
- 2009
- Full Text
- View/download PDF
13. Strategies for Odor Coding in the Piriform Cortex.
- Author
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Brann, Jessica H., Saideman, Shari R., Valley, Matthew T., and Wiedl, Denise
- Subjects
ODORS ,ELECTROPHYSIOLOGY ,CELLS ,NEURAL circuitry ,INTERNEURONS - Abstract
The article examines a study on odor coding in the piriform cortex. The authors of the study have used electrophysiological characterization of two classes of principal cells to understand the circuit in the piriform cortex. Included in unanswered questions about circuit physiology in the study are the role of different classes of interneurons on the output of the principal cells and the importance of principal cell recurrent collaterals on spatiotemporal coding.
- Published
- 2007
- Full Text
- View/download PDF
14. GABAB Receptors Tune Cortical Feedback to the Olfactory Bulb.
- Author
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Mazo C, Lepousez G, Nissant A, Valley MT, and Lledo PM
- Subjects
- Action Potentials drug effects, Action Potentials physiology, Anesthetics, Local pharmacology, Animals, Calcium-Calmodulin-Dependent Protein Kinase Kinase genetics, Calcium-Calmodulin-Dependent Protein Kinase Kinase metabolism, Channelrhodopsins, Excitatory Amino Acid Agonists pharmacology, Excitatory Postsynaptic Potentials drug effects, In Vitro Techniques, Lidocaine pharmacology, Light, Mice, Mice, Inbred C57BL, Mice, Transgenic, Odorants, Olfactory Pathways physiology, Quinoxalines pharmacology, Receptors, GABA-B genetics, Excitatory Postsynaptic Potentials physiology, Feedback, Olfactory Bulb cytology, Olfactory Cortex cytology, Receptors, GABA-B metabolism, Smell physiology
- Abstract
Unlabelled: Sensory perception emerges from the confluence of sensory inputs that encode the composition of external environment and top-down feedback that conveys information from higher brain centers. In olfaction, sensory input activity is initially processed in the olfactory bulb (OB), serving as the first central relay before being transferred to the olfactory cortex. In addition, the OB receives dense connectivity from feedback projections, so the OB has the capacity to implement a wide array of sensory neuronal computation. However, little is known about the impact and the regulation of this cortical feedback. Here, we describe a novel mechanism to gate glutamatergic feedback selectively from the anterior olfactory cortex (AOC) to the OB. Combining in vitro and in vivo electrophysiological recordings, optogenetics, and fiber-photometry-based calcium imaging applied to wild-type and conditional transgenic mice, we explore the functional consequences of circuit-specific GABA type-B receptor (GABABR) manipulation. We found that activation of presynaptic GABABRs specifically depresses synaptic transmission from the AOC to OB inhibitory interneurons, but spares direct excitation to principal neurons. As a consequence, feedforward inhibition of spontaneous and odor-evoked activity of principal neurons is diminished. We also show that tunable cortico-bulbar feedback is critical for generating beta, but not gamma, OB oscillations. Together, these results show that GABABRs on cortico-bulbar afferents gate excitatory transmission in a target-specific manner and thus shape how the OB integrates sensory inputs and top-down information., Significance Statement: The olfactory bulb (OB) receives top-down inputs from the olfactory cortex that produce direct excitation and feedforward inhibition onto mitral and tufted cells, the principal neurons. The functional role of this feedback and the mechanisms regulating the balance of feedback excitation and inhibition remain unknown. We found that GABAB receptors are expressed in cortico-bulbar axons that synapse on granule cells and receptor activation reduces the feedforward inhibition of spontaneous and odor-driven mitral and tufted cells' firing activity. In contrast, direct excitatory inputs to these principal neurons remain unchanged. This study demonstrates that activation of GABAB receptors biases the excitation/inhibition balance provided by cortical inputs to the OB, leading to profound effects on early stages of sensory information processing., (Copyright © 2016 the authors 0270-6474/16/368289-16$15.00/0.)
- Published
- 2016
- Full Text
- View/download PDF
15. Ablation of mouse adult neurogenesis alters olfactory bulb structure and olfactory fear conditioning.
- Author
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Valley MT, Mullen TR, Schultz LC, Sagdullaev BT, and Firestein S
- Abstract
Adult neurogenesis replenishes olfactory bulb (OB) interneurons throughout the life of most mammals, yet during this constant flux it remains unclear how the OB maintains a constant structure and function. In the mouse OB, we investigated the dynamics of turnover and its impact on olfactory function by ablating adult neurogenesis with an x-ray lesion to the sub-ventricular zone (SVZ). Regardless of the magnitude of the lesion to the SVZ, we found no change in the survival of young adult born granule cells (GCs) born after the lesion, and a gradual decrease in the population of GCs born before the lesion. After a lesion producing a 96% reduction of incoming adult born GCs to the OB, we found a diminished behavioral fear response to conditioned odor cues but not to audio cues. Interestingly, despite this behavioral deficit and gradual anatomical changes, we found no electrophysiological changes in the GC population assayed in vivo through dendro-dendritic synaptic plasticity and odor-evoked local field potential oscillations. These data indicate that turnover in the granule cell layer is generally decoupled from the rate of adult neurogenesis, and that OB adult neurogenesis plays a role in a wide behavioral system extending beyond the OB.
- Published
- 2009
- Full Text
- View/download PDF
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