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21 results on '"Valenti, Donatella"'

5. Tackling the challenges of the oral administration of a fermented flour extract with liposomes: Effect on intestinal HT-29 cells

Author

0000-0002-8563-4568, 0000-0003-4273-9084, 0000-0001-7063-6192, Tomassi, Elena, Lucchesi, Daniela, Caddeo, Carla, Valenti, Donatella, Sancho, Veronica, Pons Pons, Ramón, Pucci, Laura, 0000-0002-8563-4568, 0000-0003-4273-9084, 0000-0001-7063-6192, Tomassi, Elena, Lucchesi, Daniela, Caddeo, Carla, Valenti, Donatella, Sancho, Veronica, Pons Pons, Ramón, and Pucci, Laura

Abstract

LisosanG is a fermented flour that contains polyphenols, polyunsaturated fatty acids, vitamins, and alpha-lipoic acid with antioxidant/anti-inflammatory properties. These compounds are often characterized by instability, low solubility/bioavailability, and poor absorption that restrict their application in therapy. These problems can be solved by using delivery systems among which liposomes have emerged as prominent candidates. Liposomes can load compounds with varied physico-chemical properties, providing protection from degradation, increased solubility, modulation of release, and facilitated diffusion across biomembranes. Lisosan G liposomes tailored for oral administration were prepared. Eudragit® enteric polymer was added to protect the liposomes from acidic pH. The Eudragit-liposomes were around 100 nm and unilamellar. They were resistant to acidic conditions and did not alter cell viability, nor intracellular ROS levels. These findings confirm that liposomes are an efficient system for the loading of multicomponent-based extracts and that, when properly formulated, can offer protection from physiological degradation, and be safely applied to cells.

Published
2023

8. PEGylated Liposomes Loaded with Carbamate Inhibitor ANP0903 Trigger Apoptosis by Enhancing ER Stress in HepG2 Cancer Cells

Author

Caddeo, Carla, primary, Miglionico, Rocchina, additional, Rinaldi, Roberta, additional, Nigro, Ilaria, additional, Lamorte, Daniela, additional, Chiummiento, Lucia, additional, Lupattelli, Paolo, additional, Funicello, Maria, additional, D’Orsi, Rosarita, additional, Valenti, Donatella, additional, Santoro, Valentina, additional, Fadda, Anna Maria, additional, Bisaccia, Faustino, additional, Vassallo, Antonio, additional, and Armentano, Maria Francesca, additional

Published
2023
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12. Needle-Free Jet Injectors and Nanosuspensions: Exploring the Potential of an Unexpected Pair

Author

Schlich, Michele, primary, Casula, Luca, additional, Musa, Aurora, additional, Pireddu, Rosa, additional, Pitzanti, Giulia, additional, Cardia, Maria Cristina, additional, Valenti, Donatella, additional, Marceddu, Salvatore, additional, Fadda, Anna Maria, additional, De Luca, Maria Antonietta, additional, Sinico, Chiara, additional, and Lai, Francesco, additional

Published
2022
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18. Optimization of Innovative Three-Dimensionally-Structured Hybrid Vesicles to Improve the Cutaneous Delivery of Clotrimazole for the Treatment of Topical Candidiasis

Author

Manca, Maria Letizia, primary, Usach, Iris, additional, Peris, José Esteban, additional, Ibba, Antonella, additional, Orrù, Germano, additional, Valenti, Donatella, additional, Escribano-Ferrer, Elvira, additional, Gomez-Fernandez, Juan Carmelo, additional, Aranda, Francisco José, additional, Fadda, Anna Maria, additional, and Manconi, Maria, additional

Published
2019
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21. Transcutol ® P Containing SLNs for Improving 8-Methoxypsoralen Skin Delivery.

Author

Pitzanti G, Rosa A, Nieddu M, Valenti D, Pireddu R, Lai F, Cardia MC, Fadda AM, and Sinico C

Abstract

Topical psoralens plus ultraviolet A radiation (PUVA) therapy consists in the topical application of 8-methoxypsoralen (8-MOP) followed by the skin irradiation with ultraviolet A radiation. The employment of classical 8-MOP vehicles in topical PUVA therapy is associated with poor skin deposition and weak skin permeability of psoralens, thus requiring frequent drug administration. The aim of the present work was to formulate solid lipid nanoparticles (SLNs) able to increase the skin permeation of 8-MOP. For this purpose, the penetration enhancer Transcutol ® P (TRC) was added to the SLN formulation. SLNs were characterized with respect to size, polydispersity index, zeta potential, entrapment efficiency, morphology, stability, and biocompatibility. Finally, 8-MOP skin diffusion and distribution within the skin layers was investigated using Franz cells and newborn pig skin. Freshly prepared nanoparticles showed spherical shape, mean diameters ranging between 120 and 133 nm, a fairly narrow size distribution, highly negative ζ potential values, and high entrapment efficiency. Empty and loaded formulations were almost stable over 30 days. In vitro penetration and permeation studies demonstrated a greater 8-MOP accumulation in each skin layer after SLN TRC 2% and TRC 4% application than that after SLN TRC 0% application. Finally, the results of experiments on 3T3 fibroblasts showed that the incorporation of TRC into SLNs could enhance the cellular uptake of nanoparticles, but it did not increase their cytotoxicity.

Published
2020
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