Author: "Université d'Angers (UA)-Université de Rennes 1 (UR1)" / Search Limiters: Available in Library Collection - Searchworks@Jio Institute Digital Library Search Results

Your search keyword '"Université d'Angers (UA)-Université de Rennes 1 (UR1)"' showing total 1,482 results

Start Over Author "Université d'Angers (UA)-Université de Rennes 1 (UR1)" Search Limiters Available in Library Collection

1,482 results on '"Université d'Angers (UA)-Université de Rennes 1 (UR1)"'

1. Working from home in the time of COVID-19: how to best preserve occupational health?

Author: David R M Smith, Alexis Descatha, Kévin Jean, Hanifa Bouziri, William Dab, Laboratoire Modélisation, épidémiologie et surveillance des risques sanitaires (MESuRS), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Epidémiologie et modélisation de la résistance aux antimicrobiens - Epidemiology and modelling of bacterial escape to antimicrobials (EMAE), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Bodin, Julie, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Subjects: occupational health practice, Risk, Economic growth, medicine.medical_specialty, business.product_category, Coronavirus disease 2019 (COVID-19), Health Personnel, Pneumonia, Viral, Health benefits, Occupational safety and health, 03 medical and health sciences, stress, Betacoronavirus, 0302 clinical medicine, Telecommuting, Occupational Exposure, Pandemic, medicine, Internet access, Humans, 030212 general & internal medicine, Musculoskeletal Diseases, Pandemics, Occupational Health, ComputingMilieux_MISCELLANEOUS, musculoskeletal, SARS-CoV-2, Public health, public health, Public Health, Environmental and Occupational Health, Grey literature, PostScript, 030210 environmental & occupational health, 3. Good health, [STAT] Statistics [stat], [STAT]Statistics [stat], covid-19, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Business, Coronavirus Infections
Abstract: In response to the COVID-19 pandemic, many countries have adopted a broad spectrum of containment measures, from recommendations to stay at home to quarantines of large geographic regions. As part of this response, corporations and governments alike have strongly encouraged workers to telecommute where possible. More than 3.4 billion people in 84 countries have been confined to their homes, as estimated in late March 2020, which potentially translates to many millions of workers temporarily exposed to telecommuting. Since 2000, the emergence of digital and broadband internet has facilitated the development of home telework. Despite limited research interest on its impact on occupational health, several health benefits and risks of telework have been identified in academic or grey literature (table 1) (for a review see Ref. 1). …
Published: 2023

2. Psychosocial work exposures of the job strain model and cardiovascular mortality in France: results from the STRESSJEM prospective study

Author: Béatrice Geoffroy-Perez, Allison Milner, Isabelle Niedhammer, Anthony D. LaMontagne, Jean-François Chastang, Thomas Coutrot, Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), University of Melbourne, Santé publique France - French National Public Health Agency [Saint-Maurice, France], Direction de l'animation de la recherche, des études et des statistiques (DARES), Ministère du Travail, de l'Emploi et de la Santé, Deakin University [Burwood], Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Bertrais, Sandrine
Subjects: psychosocial, Male, cumulative exposure, Cumulative Exposure, Occupational Stress, 0302 clinical medicine, cardiovascular mortality, cardiovascular disease, Surveys and Questionnaires, stressjem, Medicine, Prospective Studies, Workplace, job stress, education.field_of_study, job-exposure matrix, Middle Aged, stroke, 030210 environmental & occupational health, 3. Good health, Cardiovascular Diseases, Cohort, Original Article, Female, France, Public aspects of medicine, RA1-1270, Psychosocial, prospective study, Adult, Decision Making, Population, Job-exposure matrix, 03 medical and health sciences, Social support, Environmental health, Humans, education, job strain, Job strain, business.industry, Proportional hazards model, Public Health, Environmental and Occupational Health, Social Support, JEM, ischemic heart disease, exposure, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, work exposure, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business
Abstract: International audience; Objectives The study aims to explore the prospective associations of the psychosocial work exposures of the job strain model with cardiovascular mortality, including mortality for ischemic heart diseases (IHD) and stroke, using various time-varying exposure measures in the French working population of employees. Methods The study was based on a cohort of 798 547 men and 697 785 women for which job history data from 1976 to 2002 were linked to mortality data and causes of death from the national death registry. Psychosocial work exposures from the validated job strain model questionnaire were assessed using a job-exposure matrix (JEM). Three time-varying measures of exposure were studied: current, cumulative, and recency-weighted cumulative exposure. Cox proportional hazards models were used to examine the associations between psychosocial work exposures and cardiovascular mortality. Results Within the 1976-2002 period, there were 19 264 cardiovascular deaths among men and 6181 among women. Low decision latitude, low social support, job strain, iso-strain, passive job, and high strain were associated with cardiovascular mortality. Most of these associations were also observed for IHD and stroke mortality. The comparison between the different exposure measures suggested that current exposure may be more important than cumulative (or past) exposure. The population fractions of cardiovascular mortality attributable to job strain were 5.64% for men and 6.44% for women. Conclusions Psychosocial work exposures of the job strain model may play a role in cardiovascular mortality. The estimated burden of cardiovascular mortality associated with these exposures underlines the need for preventive policies oriented toward the psychosocial work environment.
Published: 2020

3. Dupuytren's Disease and exposure to vibration: Systematic review and Meta-analysis

Author: Martin Soubrier, Geraldine Naughton, Frédéric Dutheil, Alexis Descatha, Sylvain Mathieu, CHU Clermont-Ferrand, Macquarie University, Swinburne University of Technology [Melbourne], Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Laboratoire de Psychologie Sociale et Cognitive (LAPSCO), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Service de Rhumatologie - CHU Clermont Ferrand, Université Clermont Auvergne (UCA), Department of Educational Studies, Macquarie University, Sydney, New South Wales, Australia, Department of Health and Medical Sciences, Swinburne University of Technology, Melbourne, Australia, Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Laboratoire de Psychologie Sociale et Cognitive - Clermont Auvergne (LAPSCO), Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Physiological and Psychosocial Stress, University Hospital of Clermont-Ferrand, CHU Clermont-Ferrand, Preventive and Occupational Medicine, WittyFit, Clermont-Ferrand, France., Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), and Bodin, Julie
Subjects: Work, medicine.medical_specialty, Disease, Cochrane Library, Vibration, Vibration exposure, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Risk Factors, Occupational Exposure, Diabetes mellitus, Internal medicine, Prevalence, medicine, Humans, 030212 general & internal medicine, Risk factor, ComputingMilieux_MISCELLANEOUS, 030203 arthritis & rheumatology, Entire population, Dupuytren disease, business.industry, Incidence (epidemiology), medicine.disease, [STAT] Statistics [stat], 3. Good health, Dupuytren Contracture, [STAT]Statistics [stat], Meta-analysis, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Introduction Dupuytren's Disease (DD) occurs frequently in the entire population. Several risk factors are well known, including diabetes, alcohol, and age. In this meta-analysis, we assessed the role of occupational vibration exposure in the risk of DD, an issue currently under debate. Methods We searched PubMed, Google Scholar, and the Cochrane Library to find references up to June 2019. DD prevalence was calculated using meta-proportion analysis. Differences in characteristics between DD patients and controls were expressed as standardized mean differences using the inverse of variance method or percentages using also meta-proportion analysis. We performed meta-regression analyses to assess the effects of alcohol, smoking, age, and sex on the DD incidence for the patients with DD that were exposed to vibrations. Results We included 9 studies, comprising a total of 60,570 patients, including 1,804 DD patients. Prevalence of DD was 9.8% (95%CI: 5.9–14.4%). Compared with controls, patients with DD were older, more diabetic, more smokers and with a higher consumption of alcohol. Meta-analysis of the nine longitudinal studies comparing DD occurrence between patients exposed to vibration (626 of 6825) or not (1220 of 52,502) revealed a significantly increased DD incidence among patients with vibration exposure compared with controls (OR = 2.87; 95%CI: 1.41–5.84). In metaregression we found no significant influence of all parameters on DD. Conclusion Age and environmental factors had no effect on DD prevalence among patients exposed to vibrations, despite a 10% prevalence in this group. Using vibration tools at work should be recognized as an important risk factor of developing DD.
Published: 2020

4. Working conditions and depression in the French national working population: Results from the SUMER study

Author: Sandrine Bertrais, Sarah Memmi, Kylian Coindre, Isabelle Niedhammer, Jean-François Chastang, Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Direction de l'animation de la recherche, des études et des statistiques (DARES), Ministère du Travail, de l'Emploi et de la Santé, The authors thank the members of DARES (French ministry of labour), all the occupational physicians and ‘médecins inspecteurs régionaux du travail’, and all the employees who participated to the SUMER survey and made this study possible., Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Bertrais, Sandrine
Subjects: Male, [SDV]Life Sciences [q-bio], Working conditions, Poison control, Mental health Depression, Suicide prevention, Occupational safety and health, 03 medical and health sciences, Social support, Job stress, 0302 clinical medicine, Occupational Exposure, Environmental health, Injury prevention, Humans, Medicine, Workplace, Biological Psychiatry, Depression (differential diagnoses), Occupational exposures, Depression, business.industry, Social Support, Psychosocial work factors, Mental health, 030227 psychiatry, [SDV] Life Sciences [q-bio], Occupational Diseases, Psychiatry and Mental health, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, 8. Economic growth, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Psychosocial, Stress, Psychological, 030217 neurology & neurosurgery
Abstract: Objectives The objectives were to explore the associations between various types of occupational exposures and depression in the French national working population, most of the studies in the literature focussing on a limited number of exposures and on symptom scales. Methods The study was based on a nationally representative sample of 25 977 employees, 14 682 men and 11 295 women. Depression was measured using the PHQ-9 instrument and algorithm. Occupational exposures included factors related to both the psychosocial and physical work environment. Weighted logistic regression analyses were performed to study the associations between exposures and outcome with adjustment for covariates among men and women separately. Results The prevalence of depression was higher for women than for men (5.70% versus 3.78%). The final models showed that low decision latitude, low reward, bullying, work-family and ethical conflicts for both genders, and high psychological demands, low social support, and long working hours among women were risk factors for depression. No occupational exposure of physical, biomechanical, chemical and biological nature was associated with depression. Sensitivity analyses confirmed the robustness of the results. Conclusions Significant associations were found between psychosocial work exposures and depression, and there were some differences in these associations between genders. This study is one of the first to provide a comprehensive overview of occupational exposures in association with depression. More prevention towards the psychosocial work environment is needed to improve mental health of working populations.
Published: 2020

5. O-347 Low back pain occurrence and evolution in different work situations during COVID-19 epidemic lockdown from 17 March to 10 May 2020, in metropolitan France

Author: Natacha Fouquet, Christine Chan Chee, Emilie Chazelle, Santé publique France - French National Public Health Agency [Saint-Maurice, France], Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Subjects: 030222 orthopedics, education.field_of_study, Work organization, Coronavirus disease 2019 (COVID-19), business.industry, Population, Odds ratio, Low back pain, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Increased risk, Work (electrical), medicine, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, medicine.symptom, education, business, ComputingMilieux_MISCELLANEOUS, 030217 neurology & neurosurgery, Low back, Demography
Abstract: IntroductionThe work organization of most French workers was significantly modified (extended implementation of teleworking, work interruptions…) during the first mandatory lockdown set up to fight the spread of the COVID-19 pandemic, from 17 March to 10 May 2020.ObjectivesThe aim of the study was to estimate the effects of the changes in the work organization due to lockdown on low back pain onset and its evolution.MethodsWorkers were retrospectively interviewed online during three waves of the Coviprev study (access panel in the general population) between 8 June and 8 July 2020 about their work situation during lockdown and their low back symptoms before and at the end of the lockdown.ResultsThe rate of low back pain onset in workers who did not have any low back symptoms prior to the lockdown (n=2,113) was 10.4% [9.1–10.7]. The work situation during the lockdown was associated with significantly increased risks of low back pain in people who began teleworking due to lockdown, and in those who continued to work outside home at a higher pace than usual (compared to working outside home as usual;odds ratio of 2.81 [1.77–4.46] and 2.76 [1.50–5.09], respectively). The work situation during lockdown was also significantly associated with the evolution of low back pain in workers who already suffered from it before the lockdown (n=1,111, 34.3% [32.7–36.0]) with an increased risk of worsening for those who worked outside the home at a higher pace than usual (odds ratio 3.39 [1.38–8.31]) and a higher probability of improvement for those who usually worked from home before the lockdown (odds ratio 1.86 [1.00–3.43]).ConclusionWhile the Covid-19 epidemic and teleworking take hold, measures should be implemented in order to prevent an increase in the burden of low back pain in workers.
Published: 2021

6. Update of the fractions of cardiovascular diseases and mental disorders attributable to psychosocial work factors in Europe

Author: Niedhammer, Isabelle, Sultan-Taïeb, Hélène, Parent-Thirion, Agnès, Chastang, Jean-François, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Université du Québec à Montréal = University of Québec in Montréal (UQAM), European Foundation for the Improvement of Living and Working Conditions (EUROFOUND), This study was funded by ETUI, Brussels, Belgium (Grant no: 1851-320)., Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Subjects: Male, Depression, [SDV]Life Sciences [q-bio], Attributable fraction, Mental disorders, Psychosocial work factors, Occupational Diseases, Europe, Cardiovascular diseases, Job stress, Exposure prevalence, Humans, Female, Original Article, Workplace, Stress, Psychological
Abstract: Objectives The objectives of this study were to provide the fractions of cardiovascular diseases and mental disorders attributable to five psychosocial work exposures, i.e. job strain, effort-reward imbalance, job insecurity, long working hours, and bullying in Europe (35 countries, including 28 European Union countries), for each one and all countries together, in 2015. Methods The prevalences of exposure were estimated using the sample of 35,571 employees from the 2015 European Working Conditions Survey (EWCS) for all countries together and each country separately. Relative risks (RR) were obtained via literature reviews and meta-analyses already published. The studied outcomes were: coronary/ischemic heart diseases (CHD), stroke, atrial fibrillation, peripheral artery disease, venous thromboembolism, and depression. Attributable fractions (AF) for each exposure and overall AFs for all exposures together were calculated. Results The AFs of depression were all significant: job strain (17%), job insecurity (9%), bullying (7%), and effort-reward imbalance (6%). Most of the AFs of cardiovascular diseases were significant and lower than 11%. Differences in AFs were observed between countries for depression and for long working hours. Differences between genders were found for long working hours, with higher AFs observed among men than among women for all outcomes. Overall AFs taking all exposures into account ranged between 17 and 35% for depression and between 5 and 11% for CHD. Conclusion The overall burden of depression and cardiovascular diseases attributable to psychosocial work exposures was noticeable. As these exposures are modifiable, preventive policies may be useful to reduce the burden of disease associated with the psychosocial work environment. Supplementary Information The online version contains supplementary material available at 10.1007/s00420-021-01737-4.
Published: 2021

7. Changes in the management of urinary tract infections in women: impact of the new recommendations on antibiotic prescribing behavior in France, between 2014 and 2019

Author: Piraux, Arthur, Faure, Sébastien, Naber, Kurt, Alidjanov, Jakhongir, Ramond-Roquin, Aline, Micro et Nanomédecines Translationnelles (MINT), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Department of Urology, Technical University of Munich, Department of Urology, Pediatric Urology and Andrology, Justus-Liebig University of Giessen, Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Justus-Liebig-Universität Gießen = Justus Liebig University (JLU), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Piraux, Arthur
Subjects: Urinary tract infection, Antibiotic resistance, Research, Guideline adherence, Prescriber-pharmacist collaboration, Educational intervention, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, Antimicrobial resistance, 3. Good health, Anti-Bacterial Agents, Prescriberpharmacist collaboration, [SDV.SP] Life Sciences [q-bio]/Pharmaceutical sciences, General Practitioners, Urinary Tract Infections, Humans, Antibiotic consumption, Female, France, Practice Patterns, Physicians', Public aspects of medicine, RA1-1270, Retrospective Studies
Abstract: Background Urinary tract infections (UTIs) are among the most common infections that require antibiotic therapy. In December 2015, new guidelines for UTI management were published in France with the aim of reducing antibiotic misuse and the risk of antimicrobial resistance. Objectives To analyze changes in antibiotic prescribing behavior for acute uncomplicated UTI in women in France from 2014 to 2019. Methods Retrospective study using data extracted from the medico-administrative database ‘OpenMedic’ that is linked to the French National Health Data System and collects data on the reimbursement of prescribed drugs. The analyses focused on the number of boxes of antibiotics delivered by community pharmacies, the molecule class, and the prescriber’s specialty. Results Overall, antibiotic dispensing by community pharmacies increased by 2% between 2014 and 2019, but with differences in function of the antibiotic class. The use of antibiotics recommended as first-line and second-line treatment increased (+ 41% for fosfomycin and + 7430% for pivmecillinam). Conversely, the dispensing of lomefloxacin and norfloxacin decreased by 80%, and that of ciprofloxacin by 26%. Some antibiotics were mostly prescribed by general practitioners (lomefloxacin, pivmecillinam) and others by secondary care physicians (ofloxacin). Dispensing increased for antibiotics prescribed by secondary care physicians (+ 13% between 2014 and 2019) and decreased for antibiotics prescribed by GPs (− 2% for the same period). Conclusion These data suggest that the new recommendations are followed, as indicated by the increased prescription of fosfomycin and pivmecillinam and decreased prescription of fluoroquinolones. However, the efficient transmission and implementation of new recommendations by practitioners requires time, means and dedicated tools. Supplementary Information The online version contains supplementary material available at 10.1186/s12913-021-06653-4.
Published: 2021

8. The CONSTANCES job exposure matrix based on self-reported exposure to physical risk factors: development and evaluation

Author: Johan Hviid Andersen, Yves Roquelaure, Alexis Descatha, Skye Buckner-Petty, Ann Marie Dale, Bradley A. Evanoff, Marcus Yung, Washington University in Saint Louis (WUSTL), University research clinic [Herning, Denmark], Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Paris (UP), Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Raymond Poincaré [AP-HP], American National Institute for Occupational Safety and Health [NIOSH R01OH011076], French National Research Agency [ANR-11-INBS-0002], Caisse Nationale d'Assurance Maladie des travailleurs salariesCNAMTS, Institut de Recherche en Sante Publique/Institut Thematique Sante Publique, Ministere de la sante et des sports, Ministere delegue a la recherche, Institut national du cancer et Caisse nationale de solidarite pour l'autonomie, Institute for research in public health (IReSP, CapaciT project), Institut national de la sante et de la recherche medicale, Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), ANR-11-INBS-0002,CONSTANCES,La cohorte CONSTANCES - Infrastructure épidémiologique ouverte pour la recherche et la surveillance(2011), Jonchère, Laurent, and Infrastructures - La cohorte CONSTANCES - Infrastructure épidémiologique ouverte pour la recherche et la surveillance - - CONSTANCES2011 - ANR-11-INBS-0002 - INBS - VALID
Subjects: Male, exposure assessment, Exposure Assessment, France/epidemiology, DISEASE, Program Evaluation/methods, 0302 clinical medicine, Multivariate analysis of variance, RATINGS, Risk Factors, Statistics, occupational biomechanical exposure, EPIDEMIOLOGY, 030212 general & internal medicine, Occupational Health/standards, OCCUPATIONAL EXPOSURES, education.field_of_study, COST, Variance (accounting), Middle Aged, Occupational Injuries/epidemiology, 030210 environmental & occupational health, POSTURES, Self Report/standards, Female, Metric (unit), Analysis of variance, France, musculoskeletal disorders, Risk assessment, Psychology, BACK, Adult, Adolescent, Population, Job-exposure matrix, Risk Assessment, 03 medical and health sciences, Occupational Exposure, [SDV.EE.SANT] Life Sciences [q-bio]/Ecology, environment/Health, Humans, education, Risk Assessment/methods, O-ASTERISK-NET, Occupational Health, Exposure assessment, Aged, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, Analysis of Variance, MOVEMENTS, Occupational Exposure/adverse effects, Public Health, Environmental and Occupational Health, Occupational Injuries, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, ergonomics, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Self Report, WORK LOAD, Program Evaluation
Abstract: ObjectivesJob exposure matrices (JEMs) can be constructed from expert-rated assessments, direct measurement and self-reports. This paper describes the construction of a general population JEM based on self-reported physical exposures, its ability to create homogeneous exposure groups (HEG) and the use of different exposure metrics to express job-level estimates.MethodsThe JEM was constructed from physical exposure data obtained from the Cohorte des consultants des Centres d’examens de santé (CONSTANCES). Using data from 35 526 eligible participants, the JEM consisted of 27 physical risk factors from 407 job codes. We determined whether the JEM created HEG by performing non-parametric multivariate analysis of variance (NPMANOVA). We compared three exposure metrics (mean, bias-corrected mean, median) by calculating within-job and between-job variances, and by residual plots between each metric and individual reported exposure.ResultsNPMANOVA showed significantly higher between-job than within-job variance among the 27 risk factors (F(253,21964)=61.33, p2=41.1%). The bias-corrected mean produced more favourable HEG as we observed higher between-job variance and more explained variance than either means or medians. When compared with individual reported exposures, the bias-corrected mean led to near-zero mean differences and lower variance than other exposure metrics.ConclusionsCONSTANCES JEM using self-reported data yielded HEGs, and can thus classify individual participants based on job title. The bias-corrected mean metric may better reflect the shape of the underlying exposure distribution. This JEM opens new possibilities for using unbiased exposure estimates to study the effects of workplace physical exposures on a variety of health conditions within a large general population study.
Published: 2019

9. Clinical guidelines and care pathway for management of low back pain with or without radicular pain

Author: Thomas Le Vraux, Gilles Vuides, Florian Bailly, Catherine Sebire, Sabrina Dadoun, Jean-Baptiste Fassier, Rogatien Faguer, Sylvie Rozenberg, MichÃ le Koleck, FranÃ Ois Rannou, Karine Petitprez, Alexandra Roren, Sandrine Bercier, Liesse Brigitte, Louis Lassalle, Aline Ramond-Roquin, Anne-Priscille Trouvin, Jean-Philippe Deneuville, Petit Audrey, Jean-FranÃ Ois Renard, CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris-Est Créteil Val-de-Marne - Faculté de médecine (UPEC Médecine), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Clinique Geoffroy Saint-Hilaire, Institut Pprime (PPRIME), Université de Poitiers-ENSMA-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Hospices Civils de Lyon (HCL), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Radiologie [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Haute Autorité de Santé [Saint-Denis La Plaine] (HAS), Laboratoire d'Ergonomie et d'Épidémiologie en Santé au Travail (LEEST), Université d'Angers (UA)-Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)-Institut de Veille Sanitaire (INVS), Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Service de rééducation et de réadaptation de l'appareil locomoteur et des pathologies du rachis [CHU Cochin], Admin, Oskar, Service de Rhumatologie [CHU Pitié Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de rhumatologie [CHU Pitié Salpêtrière] (GRC-08 EEMOIS), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Université de Bordeaux (UB), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Subjects: medicine.medical_specialty, Consensus, Guidelines, Recommendations, Academic institution, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Musculoskeletal Pain, Multidisciplinary approach, medicine, Care pathway, Humans, Low back pain, 030212 general & internal medicine, 030203 arthritis & rheumatology, business.industry, Guideline, medicine.disease, 3. Good health, Systematic review, Radicular pain, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Family medicine, Critical Pathways, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Patient representatives, medicine.symptom, business, Systematic Reviews as Topic
Abstract: International audience; OBJECTIVE: To develop guidelines for low back pain management according to previous international guidelines and the updated literature. METHODS: A report was compiled from a review of systematic reviews of guidelines published between 2013 and 2018 and meta-analysis of the management of low back pain published between 2015 and 2018. This report summarized the state-of-the-art scientific knowledge for each predefined area of the guidelines from a critical review of selected literature. A multidisciplinary panel of experts including 17 health professionals involved in low back pain management and 2 patient representatives formulated preliminary guidelines based on the compilation report and a care pathway. The compilation report and preliminary guidelines were submitted to 25 academic institutions and stakeholders for the consultation phase. From responses of academic institutions and stakeholders, the final guidelines were developed. For each area of the guidelines, agreement between experts was assessed by the RAND/UCLA method. RESULTS: The expert panel drafted 32 preliminary recommendations including a care pathway, which was amended after academic institution and stakeholder consultation. The consensus of the multidisciplinary expert panel was assessed for each final guideline: 32 recommendations were assessed as appropriate; none was assessed as uncertain or inappropriate. Strong approval was obtained for 27 recommendations and weak for 5. CONCLUSION: These new guidelines introduce several concepts, including the need to early identify low back pain at risk of chronicity to provide quicker intensive and multidisciplinary management if necessary.
Published: 2021

10. Multiple psychosocial work exposures and well-being among employees: prospective associations from the French national Working Conditions Survey

Author: Isabelle Niedhammer, Sandrine Bertrais, Jean-François Chastang, Nora Hérault, Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), 2018/037, DARES of the French ministry of labour, Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Bertrais, Sandrine
Subjects: Male, [SDV]Life Sciences [q-bio], Well-being, Working conditions, 03 medical and health sciences, symbols.namesake, 0302 clinical medicine, Noise exposure, Risk Factors, Environmental health, Occupational Exposure, Surveys and Questionnaires, Medicine, Humans, 030212 general & internal medicine, Poisson regression, Workplace, business.industry, Public Health, Environmental and Occupational Health, General Medicine, Psychosocial work factors, 030210 environmental & occupational health, Working time, Mental health, Work environment, [SDV] Life Sciences [q-bio], Occupational Diseases, Occupational Exposures, Multiple exposures, stomatognathic diseases, Work (electrical), [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, 8. Economic growth, symbols, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, business, Psychosocial, Stress, Psychological
Abstract: International audience; Aims: Working conditions, especially psychosocial work factors (PWFs), are thought to influence mental health outcomes among working populations, but there have been few studies on well-being per se. We assessed the prospective associations between a wide variety of occupational factors, including PWFs, multiple exposure to these factors, and well-being among employees in France. Methods: This study was based on a nationally representative sample of 15,776 employees, including 6595 men and 9181 women, followed up from 2013 to 2016. Psychological well-being was assessed using the WHO-5 Well-Being Index. Occupational factors included 20 PWFs, 4 factors related to working time/hours, and 4 physical work exposures. The associations of occupational exposures with poor well-being were estimated using weighted robust Poisson regression models in men and women separately. Results: Among the employees who rated their well-being as good in 2013, 10.3% of men and 16.8% of women had a poor well-being 3 years later. Most PWFs in 2013 were associated with poor well-being in 2016 among women, and half of them among men. An increase in the risk of poor well-being with the number of PWFs was found. Noise exposure was associated with poor well-being in women. Conclusions: The occupational factors associated with psychological well-being were mainly those related to the psychosocial work environment. A linear association was observed between the number of exposures to PWFs and well-being. Preventive policies focused on PWFs may be beneficial for well-being. More attention should be given to multiple exposures to these factors.
Published: 2021

11. Differences between risk situations identified using a self-reported questionnaire and an observational method

Author: Maxime Norval, Julie Bodin, Yves Roquelaure, Mohsen Zare, Edition, Littératures, Langages, Informatique, Arts, Didactique, Discours - UFC (EA 4661) (ELLIADD), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Chard-Hutchinson, Xavier, Edition, Littératures, Langages, Informatique, Arts, Didactique, Discours - UFC (UR 4661) (ELLIADD), and Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Subjects: [SDV]Life Sciences [q-bio], Sample (statistics), automotive assembly tasks, Observational method, 03 medical and health sciences, 0302 clinical medicine, Cohen's kappa, Risk Factors, Surveys and Questionnaires, Statistics, Humans, 0501 psychology and cognitive sciences, Musculoskeletal Diseases, 050107 human factors, Estimation, 05 social sciences, Rehabilitation, Public Health, Environmental and Occupational Health, Human factors and ergonomics, 030210 environmental & occupational health, Risk estimation, Occupational Diseases, [SDV] Life Sciences [q-bio], assessment tool, Ergonomics, Self Report, musculoskeletal disorders, Risk assessment, Psychology, Self reported questionnaire
Abstract: International audience; Background:This study investigates work-related musculoskeletal disorders risk estimation by frequently as used as ergonomic methods in the field. Objective:To identify the difference in risk estimation by an in-house observational method and a self-reported questionnaire, and to evaluate the complementary aspects of these methods. Methods:A sample of 15 operators who worked on the assembly workstations was selected from a truck manufacturing plant. The risk assessment of these workstations (28 scenarios) was performed by the observational method and the self-reported questionnaire. The agreement between both methods to identify risk situations was measured with the weighted Kappa coefficient. Results:The observational method and the self-reported questionnaire deployed on the same activity estimated different risk situations. Conclusion:This analysis does not reveal that one tool is more powerful than the other one, but shows the probability of different risk estimation. The complementary effect of each method might be considered for further investigation concerning musculoskeletal risk factors.
Published: 2021

12. A Protocol for the Use of Case Reports/Studies and Case Series in Systematic Reviews for Clinical Toxicology

Author: Nambiema, Aboubakari, Sembajwe, Grace, Lam, Juleen, Woodruff, Tracey, Mandrioli, Daniele, Chartres, Nicholas, Fadel, Marc, Le Guillou, Adrien, Valter, Remi, Deguigne, Marie, Legeay, Marion, Bruneau, Chloe, Le Roux, Gaël, Descatha, Alexis, Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), This project was supported by the French Pays de la Loire region and Angers Loire Métropole, University of Angers and Centre Hospitalo-Universitaire CHU Angers. The project is entitled TEC-TOP (no award/grant number)., and Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Subjects: [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, case series Nambiema et al. Case Reports/Series and Systematic Review, public health, case series, studies, Study Protocol, systematic review, [SDV.TOX]Life Sciences [q-bio]/Toxicology, case reports, Medicine, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, epidemiology, protocol, Generic health relevance, case reports/studies, toxicology
Abstract: International audience; Introduction: Systematic reviews are routinely used to synthesize current science and evaluate the evidential strength and quality of resulting recommendations. For specific events, such as rare acute poisonings or preliminary reports of new drugs, we posit that case reports/studies and case series (human subjects research with no control group) may provide important evidence for systematic reviews. Our aim, therefore, is to present a protocol that uses rigorous selection criteria, to distinguish high quality case reports/studies and case series for inclusion in systematic reviews. Methods: This protocol will adapt the existing Navigation Guide methodology for specific inclusion of case studies. The usual procedure for systematic reviews will be followed. Case reports/studies and case series will be specified in the search strategy and included in separate sections. Data from these sources will be extracted and where possible, quantitatively synthesized. Criteria for integrating cases reports/studies and case series into the overall body of evidence are that these studies will need to be well-documented, scientifically rigorous, and follow ethical practices. The instructions and standards for evaluating risk of bias will be based on the Navigation Guide. The risk of bias, quality of evidence and the strength of recommendations will be assessed by two independent review teams that are blinded to each other. Conclusion: This is a protocol specified for systematic reviews that use case reports/studies and case series to evaluate the quality of evidence and strength of recommendations in disciplines like clinical toxicology, where case reports/studies are the norm.
Published: 2021

13. The effect of exposure to long working hours on alcohol consumption, risky drinking and alcohol use disorder : A systematic review and meta-analysis from the WHO/ILO Joint Estimates of the Work-related burden of disease and injury

Author: Daniela Vianna Pachito, Godelieve Vandersmissen, Emma Boonen, Alexis Descatha, Dirk De Bacquer, Johannes Siegrist, Carolina de Oliveira Cruz Latorraca, Rachel Riera, Jelena Bakusic, Els Clays, Karoliina Koskenvuo, Marie-Claire Lambrechts, Frank Pega, Sakari Suominen, Markku Sumanen, Reiner Rugulies, Yuka Ujita, Ellen Delvaux, Ana Luiza Cabrera Martimbianco, Lauri Sillanmäki, Jian Li, Lode Godderis, Grace Sembajwe, Hannes Kröger, Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Universiteit Gent = Ghent University [Belgium] (UGENT), Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), University of Helsinki, German Institute for Economic Research (DIW Berlin), Universidade Federal de São Paulo, University of California [Los Angeles] (UCLA), University of California, Universidade de São Paulo (USP), University of Copenhagen = Københavns Universitet (KU), City College of New York [CUNY] (CCNY), City University of New York [New York] (CUNY), University of Dusseldorf, University of Turku, University of Tampere [Finland], World Health Organization, Universiteit Gent = Ghent University (UGENT), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, University of California (UC), Universidade de São Paulo = University of São Paulo (USP), University of Copenhagen = Københavns Universitet (UCPH), and Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf]
Subjects: PROTOCOL, STRESS, 010504 meteorology & atmospheric sciences, EVIDENCE-BASED MEDICINE, [SDV]Life Sciences [q-bio], Alcohol use disorder, 010501 environmental sciences, 01 natural sciences, law.invention, Randomized controlled trial, Cost of Illness, law, Medicine and Health Sciences, Medicine, Alcohol consumption, lcsh:Environmental sciences, General Environmental Science, lcsh:GE1-350, Public Health, Global Health, Social Medicine and Epidemiology, 3. Good health, NATIONAL LONGITUDINAL SURVEY, Europe, Occupational Diseases, Global burden of disease, Alcoholism, Systematic review, Meta-analysis, Female, HEALTH, Cohort study, Adolescent, Alcohol Drinking, World Health Organization, Work related, Article, Environmental health, Occupational Exposure, ddc:330, Humans, CORONARY-HEART-DISEASE, 0105 earth and related environmental sciences, Occupational health, business.industry, SICK LEAVE, medicine.disease, Confidence interval, Long working hours, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Relative risk, BELGIAN WORKFORCE, COHORT PROFILE, business, METHODOLOGY
Abstract: Highlights • We analysed estimates of effect of long working hours on alcohol use and disorders. • Overall body of evidence was of low certainty. • Exposure to long working hours potentially increased alcohol consumption. • The effect of long working hours on risky drinking is unclear. • We found no eligible studies on the effect on alcohol use disorder., Background The World Health Organization (WHO) and the International Labour Organization (ILO) are developing Joint Estimates of the work-related burden of disease and injury (WHO/ILO Joint Estimates), with contributions from a large network of experts. Evidence from mechanistic data suggests that exposure to long working hours may increase alcohol consumption and cause alcohol use disorder. In this paper, we present a systematic review and meta-analysis of parameters for estimating the number of deaths and disability-adjusted life years from alcohol consumption and alcohol use disorder that are attributable to exposure to long working hours, for the development of the WHO/ILO Joint Estimates. Objectives We aimed to systematically review and meta-analyse estimates of the effect of exposure to long working hours (three categories: 41–48, 49–54 and ≥55 h/week), compared with exposure to standard working hours (35–40 h/week), on alcohol consumption, risky drinking (three outcomes: prevalence, incidence and mortality) and alcohol use disorder (three outcomes: prevalence, incidence and mortality). Data sources We developed and published a protocol, applying the Navigation Guide as an organizing systematic review framework where feasible. We searched electronic bibliographic databases for potentially relevant records from published and unpublished studies, including the WHO International Clinical Trials Register, Ovid MEDLINE, PubMed, Embase, and CISDOC on 30 June 2018. Searches on PubMed were updated on 18 April 2020. We also searched electronic grey literature databases, Internet search engines and organizational websites; hand-searched reference list of previous systematic reviews and included study records; and consulted additional experts. Study eligibility and criteria We included working-age (≥15 years) workers in the formal and informal economy in any WHO and/or ILO Member State but excluded children (
Published: 2021

14. Psychosocial work exposures and health outcomes: a meta-review of 72 literature reviews with meta-analysis

Author: Niedhammer, Isabelle, Bertrais, Sandrine, Witt, Katrina, Bertrais, Sandrine, Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Orygen Youth Health Research Centre [Melbourne], University of Melbourne, Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Subjects: psychosocial, literature review, Mental Disorders, [SDV]Life Sciences [q-bio], systematic literature review, pooled estimate, Coronary Disease, psychosocial work exposure, meta-analysis, [SDV] Life Sciences [q-bio], Editorial, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, work exposure, Humans, health outcome, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Public aspects of medicine, RA1-1270, meta-review, ComputingMilieux_MISCELLANEOUS
Abstract: OBJECTIVE: This meta-review aimed to present all available quantitative pooled estimates for the associations between psychosocial work exposures and health outcomes using a systematic literature review of literature reviews with meta-analysis. METHODS: A systematic review of the literature from 2000 to 2020 was conducted using PubMed, Web of Science, Scopus, and PsycINFO databases following the PRISMA guidelines. All literature reviews and Individual-Participant Data (IPD)-Work consortium studies exploring an association between psychosocial work exposures and health outcomes and providing pooled estimates using meta-analysis were included. All types of psychosocial work exposures and health outcomes were studied. The quality of each included review was assessed. RESULTS: A total of 72 reviews and IPD-Work consortium studies were included. These mainly focused on job strain as exposure and cardiovascular diseases and mental disorders as outcomes. The associations between psychosocial work factors and cardiovascular diseases and mental disorders were in general significant, and the magnitude of these associations was stronger for mental disorders than for cardiovascular diseases. Based on high-quality reviews, significant associations were found between job/high strain and long working hours as exposures and coronary heart diseases, (ischemic) stroke, and depression as outcomes. A few additional significant associations involved other exposures and health outcomes. CONCLUSIONS: The included reviews brought convincing findings on the associations of some psychosocial work factors with mental disorders and cardiovascular diseases. More research may be needed to explain these associations, explore other exposures and outcomes, and make progress towards determining the causality of the associations.
Published: 2021

15. Proportion of upper extremity musculoskeletal disorders attributable to personal and occupational factors: results from the French Pays de la Loire study

Author: Aboubakari Nambiema, Sandrine Bertrais, Julie Bodin, Natacha Fouquet, Aublet-Cuvelier, A., Evanoff, B., Alexis Descatha, Yves Roquelaure, Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Santé publique France - French National Public Health Agency [Saint-Maurice, France], Institut national de recherche et de sécurité (Vandoeuvre lès Nancy) (INRS ( Vandoeuvre lès Nancy)), Washington University School of Medicine in St. Louis, Washington University in Saint Louis (WUSTL), Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Paris (UP), Grant 9/25/2002–5 'réseau expérimental de surveillance des troubles musculo-squelettiques', Santé publique France, the French national public health agency, Saint-Maurice, France, Grant EST-2016/1/42, The French National Research Program for Environmental and Occupational Health of Anses, Rubion, Elise, Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), and Nambiema, Aboubakari
Subjects: Adult, Male, Incidence, lcsh:Public aspects of medicine, lcsh:RA1-1270, Middle Aged, Occupational Diseases, Upper Extremity, Upper extremity musculoskeletal disorders, Young Adult, Risk factors, Population attributable fraction, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Occupational Exposure, Humans, Regression Analysis, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Ergonomics, France, Musculoskeletal Diseases, ComputingMilieux_MISCELLANEOUS, Proportional Hazards Models, Research Article
Abstract: Background Upper extremity musculoskeletal disorders (UEMSD) are one of the most common and costly occupational health problems. We aimed to assess the population-attributable fraction (PAF) of personal and occupational risk factors associated with incident UEMSD in a working population. Methods From 2002 to 2005, a random sample of 3710 workers from the Pays de la Loire region in France, aged 20–59 were included by occupational physicians (OPs). Between 2007 and 2010, 1611 workers were re-examined by their OPs. Subjects free from UEMSD at baseline were included in this study (1275 workers, mean age: 38.2 years). Cox regression models with equal follow-up time and robust variance estimates were used to estimate age-adjusted and multivariable-adjusted relative risks (RRs) and their 95% confidence intervals (CIs). Based on multivariable models, PAF associated with each factor included in the models was estimated. Results During the follow-up period, 143 (11%) cases of UEMSD were diagnosed. PAFs for factors associated with the incident UEMSD risk were 30% (7 to 51) for high physical exertion (RPE Borg scale ≥12), 12% (− 0.2 to 24) for low social support, 7% (− 3 to 17) for working with arms above shoulder level (≥2 h/day), 20% (12 to 28) for age group ≥45, 13% (3 to 22) for the age group 35–44, and 12% (0.3 to 24) for female gender. Conclusions Our study suggests that an important fraction of UEMSD can be attributed to occupational exposures after the contributions of personal and other work-related factors are considered. In terms of public health, our findings are in agreement with the ergonomic literature postulating that a high proportion of UEMSD are preventable through modifying workplace risk factors. Such information is useful to help public health practitioners and policy makers implement programs of prevention of UEMSD in the working population.
Published: 2020

16. Adaptation by copy number variation increases insecticide resistance in fall armyworms

Author: Sabine Hänniger, Fabrice Legeai, Carlos A. Blanco, Sylvie Gimenez, Nicolas Nègre, Emmanuelle d'Alençon, Kiwoong Nam, Anthony Bretaudeau, Frédérique Hilliou, Diversité, Génomes & Interactions Microorganismes - Insectes [Montpellier] (DGIMI), Université de Montpellier (UM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut Sophia Agrobiotech (ISA), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Côte d'Azur (UCA), United States Department of Agriculture (USDA), Max Planck Institute for Chemical Ecology, Max-Planck-Gesellschaft, Institut de Génétique, Environnement et Protection des Plantes (IGEPP), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Plateforme Protéomique-Biogenouest (PPB), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Proteomics Core Facility (Protim), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Plateforme Génomique Santé Biogenouest®-Plateforme Génomique Santé Biogenouest®, Scalable, Optimized and Parallel Algorithms for Genomics (GenScale), Inria Rennes – Bretagne Atlantique, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-GESTION DES DONNÉES ET DE LA CONNAISSANCE (IRISA-D7), Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Université de Bretagne Sud (UBS)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National de Recherche en Informatique et en Automatique (Inria)-École normale supérieure - Rennes (ENS Rennes)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-CentraleSupélec-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Bretagne Sud (UBS)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-École normale supérieure - Rennes (ENS Rennes)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Université Nice Sophia Antipolis (1965 - 2019) (UNS), Université de Rennes (UR)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-INSTITUT AGRO Agrocampus Ouest, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Proteomics Core Facility (Protim), Université de Rennes (UR)-Plateforme Génomique Santé Biogenouest®-Plateforme Génomique Santé Biogenouest®, Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), and Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique)
Subjects: 0106 biological sciences, 2. Zero hunger, Genetics, 0303 health sciences, biology, business.industry, [SDV]Life Sciences [q-bio], Pest control, Locus (genetics), Spodoptera, biology.organism_classification, 01 natural sciences, Lepidoptera genitalia, 010602 entomology, 03 medical and health sciences, Insecticide resistance, Copy-number variation, Allele, business, Gene, 030304 developmental biology
Abstract: Insecticide resistance is a major main challenge in pest control, and understanding its genetic basis is a key topic in agricultural ecology. Detoxification genes are well-known genetic elements that play a key role in adaptation to xenobiotics. The adaptive evolution of detoxification genes by copy number variations has been interpreted as a cause of insecticide resistance. However, the same pattern can be generated by the adaptation to host-plant defense toxins as well. In this study, we tested in fall armyworms (Lepidoptera Spodoptera frugiperda) if adaptation by copy number variation is the cause of the increased level of insecticide resistance from two geographic populations with different levels of resistance and two strains with different host plants. Following the generation of an assembly with chromosome-sized scaffolds (N50 = 13.2Mb), we observed that these two populations show a significant allelic differentiation of copy number variations, which is not observed between strains. In particular, a locus with almost complete allelic differentiation (Fst > 0.8) includes a cluster of P450 genes, which are well-known key players in detoxification. Detoxification genes are overrepresented in the genes with copy number variations, and the observed copy number variation appears to have beneficial effects in general. From this result, we concluded that copy number variation of detoxification genes in fall armyworms plays a key role in the insecticide resistance but not in the adaptation to host-plants, suggesting that the evolution of insecticide resistance may occur independently from host-plant adaptation.
Published: 2020

17. The effect of exposure to long working hours on stroke: A systematic review and meta -analysis from the WHO/ILO Joint Estimates of the Work -related Burden of Disease and Injury

Author: Alexis Descatha, Grace Sembajwe, Frank Pega, Yuka Ujita, Michael Baer, Fabio Boccuni, Cristina Di Tecco, Clement Duret, Bradley A. Evanoff, Diana Gagliardi, Lode Godderis, Seong-Kyu Kang, Beon Joon Kim, Jian Li, Linda L. Magnusson Hanson, Alessandro Marinaccio, Anna Ozguler, Daniela Pachito, John Pell, Fernando Pico, Matteo Ronchetti, Yves Roquelaure, Reiner Rugulies, Martijn Schouteden, Johannes Siegrist, Akizumi Tsutsumi, Sergio Iavicoli, Hôpital Raymond Poincaré [AP-HP], Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Paris (UP), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Hofstra University [Hempstead], Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), International Labour Organization (ILO), International Labour Organization, Istituto Nazionale per l’Assicurazione contro gli Infortuni sul Lavoro [Italian Workers Compensation Authority] (INAIL), Washington University School of Medicine in St. Louis, Washington University in Saint Louis (WUSTL), Idewe, Gachon University Gil Medical Center [Incheon, Republic of Korea], Seoul National University Hospital, University of California San Francisco School of Nursing, San Francisco, California., Stress Research Institute, Stockholm University, Hospital Sirio Libanes, Hunter College Library [New York, NY, USA], Centre Hospitalier de Versailles André Mignot (CHV), Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Department of Public Health [Copenhagen], Faculty of Health and Medical Sciences, University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), Department of Psychology [Copenhagen], Faculty of Social Sciences [Copenhagen], University of Dusseldorf, Institut für Medizinische Soziologie, Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf], Kitasato University School of Medicine, National Institute for Occupational Safety and Health, World Health Organization, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH), Bodin, Julie, Shanghai Jiao Tong University [Shanghai], Department of Public Health, State University of Ghent, INAIL, Department of Epidemiology and Public Health, Imperial College London, City University of New York [New York] (CUNY), Department of Obstetrics, Gynecology and Reproductive Sciences, University of California [San Francisco] (UCSF), University of California-University of California, and Heinrich-Heine-Universität Düsseldorf [Düsseldorf]
Subjects: PROTOCOL, Work, STRESS, EVIDENCE-BASED MEDICINE, Adolescent, 010504 meteorology & atmospheric sciences, 010501 environmental sciences, World Health Organization, 01 natural sciences, Long working Stroke, UNPUBLISHED DATA, Global Burden of Disease, Cohort Studies, Cost of Illness, Occupational Exposure, EPIDEMIOLOGY, Humans, CORONARY-HEART-DISEASE, OVERTIME WORK, lcsh:Environmental sciences, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences, General Environmental Science, lcsh:GE1-350, Stroke Occupational, Systematic review Meta-analysis, Occupational, 3. Good health, [STAT] Statistics [stat], Europe, Occupational Diseases, [STAT]Statistics [stat], Long working hours, Stroke, Meta-analysis, CARDIOVASCULAR-DISEASE, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Systematic review, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, HEALTH, PSYCHOSOCIAL FACTORS
Abstract: BACKGROUND: The World Health Organization (WHO) and the International Labour Organization (ILO) are developing joint estimates of the work-related burden of disease and injury (WHO/ILO Joint Estimates), with contributions from a large network of individual experts. Evidence from mechanistic data and prior studies suggests that exposure to long working hours may cause stroke. In this paper, we present a systematic review and meta-analysis of parameters for estimating the number of deaths and disability-adjusted life years from stroke that are attributable to exposure to long working hours, for the development of the WHO/ILO Joint Estimates. OBJECTIVES: We aimed to systematically review and meta-analyse estimates of the effect of exposure to long working hours (three categories: 41-48, 49-54 and ≥55 h/week), compared with exposure to standard working hours (35-40 h/week), on stroke (three outcomes: prevalence, incidence, and mortality). DATA SOURCES: A protocol was developed and published, applying the Navigation Guide to systematic reviews as an organizing framework where feasible. We searched electronic databases for potentially relevant records from published and unpublished studies, including Ovid MEDLINE, PubMed, EMBASE, Scopus, Web of Science, CISDOC, PsycINFO, and WHO ICTRP. We also searched grey literature databases, Internet search engines, and organizational websites; hand-searched reference lists of previous systematic reviews; and consulted additional experts. STUDY ELIGIBILITY AND CRITERIA: We included working-age (≥15 years) individuals in the formal and informal economy in any WHO and/or ILO Member State but excluded children (aged
Published: 2020

18. Quantification of Exposure to Risk Postures in Truck Assembly Operators: Neck, Back, Arms and Wrists

Author: Jean-Claude Sagot, Yves Roquelaure, Mohsen Zare, Julie Bodin, Edition, Littératures, Langages, Informatique, Arts, Didactique, Discours - UFC (EA 4661) (ELLIADD), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Edition, Littératures, Langages, Informatique, Arts, Didactique, Discours - UFC (UR 4661) (ELLIADD), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Jonchère, Laurent
Subjects: Truck, medicine.medical_specialty, Percentile, Health, Toxicology and Mutagenesis, Posture, lcsh:Medicine, Objective data, Wrist, Article, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, Manufacturing Industry, automotive assembly plant, medicine, Humans, 0501 psychology and cognitive sciences, Musculoskeletal Diseases, 050107 human factors, Back, Arm elevation, quantitative measurement, Potential risk, business.industry, lcsh:R, 05 social sciences, Public Health, Environmental and Occupational Health, 030210 environmental & occupational health, Occupational Diseases, Motor Vehicles, medicine.anatomical_structure, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, ergonomics, Arm, Neck flexion, Upper limb, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, musculoskeletal disorders, business, human activities, risk evaluation
Abstract: The study assessed the proportion of time in risky postures for the main joints of the upper limbs in a truck assembly plant and explored the association with musculoskeletal symptoms. Fourteen workstations (13 individuals) of a truck assembly plant were selected, and seven sensors were placed on the body segments of the participants. The sensors included tri-axial accelerometers for the arms and back, inclinometers for the neck and electro-goniometry for quantifying flexion/extension of the right and left hands. The proportions of time in moderate awkward postures were high at all workstations. Neck and wrist excessive awkward postures were observed for most workstations. The average values of the 91st percentile for back flexion and right/left arm elevation were 25&deg, 62&deg, and 57&deg, respectively. The 91st and 9th percentile averages for neck flexion/extension were 35.9&deg, and &minus, 4.7&deg, respectively. An insignificant relationship was found between the percentage of time spent in awkward upper limb posture and musculoskeletal symptoms. The findings provide objective and quantitative data about time exposure, variability, and potential risk factors in the real workplace. Quantitative measurements in the field provide objective data of the body postures and movements of tasks that can be helpful in the musculoskeletal disorders (MSDs) prevention program.
Published: 2020
Full Text: View/download PDF

19. Diesel Engine Exhaust Exposure, Smoking, and Lung Cancer Subtype Risks. A Pooled Exposure-Response Analysis of 14 Case-Control Studies

Author: Ge, Calvin, Peters, Susan, Olsson, Ann, Portengen, Lützen, Schüz, Joachim, Almansa, Josué, Ahrens, Wolfgang, Bencko, Vladimir, Benhamou, Simone, Boffetta, Paolo, Bueno-de-Mesquita, Bas, Caporaso, Neil, Consonni, Dario, Demers, Paul, Fabiánová, Eleonóra, Fernández-Tardón, Guillermo, Field, John, Forastiere, Francesco, Foretova, Lenka, Guénel, Pascal, Gustavsson, Per, Janout, Vladimir, Jöckel, Karl Heinz, Karrasch, Stefan, Teresa Landi, Maria, Lissowska, Jolanta, Luce, Danièle, Mates, Dana, McLaughlin, John, Merletti, Franco, Mirabelli, Dario, Pándics, Tamás, Parent, Marie Élise, Plato, Nils, Pohlabeln, Hermann, Richiardi, Lorenzo, Siemiatycki, Jack, Świątkowska, Beata, Tardón, Adonina, Wichmann, Heinz Erich, Zaridze, David, Straif, Kurt, Kromhout, Hans, Vermeulen, Roel, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Division of Environmental Epidemiology, Utrecht University [Utrecht]-Institute of Risk Assessment Sciences, Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Institute for Risk Assessment Sciences, Utrecht University [Utrecht], Bremen Institute for Prevention Research and Social Medicine (BIPS), Division of Epidemiological Methods and Etiologic Research, University of Bremen, Institute of Hygiene and Epidemiology, Charles University [Prague] (CU)-1st Faculty of Medicine, Variabilité Génétique et Maladies Humaines, Institut Universitaire d'Hématologie (IUH), Université Paris Diderot - Paris 7 (UPD7)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Icahn School of Medicine at Mount Sinai [New York] (MSSM), Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment [Bilthoven] (RIVM), National Cancer Institute [Bethesda] (NCI-NIH), National Institutes of Health [Bethesda] (NIH), Unit of Epidemiology, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, University of Toronto, Regional Authority of Public Health [Slovaquia] (RAPH), Ministry of Health of the Slovak Republic [Slovaquia], Azienda Sanitaria Locale [ROMA] (ASL), Masaryk Memorial Cancer Institute, Masaryk Memorial Cancer Institute (RECAMO), Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), The Institute of Environmental Medicine [Stockholm] (IMM), Karolinska Institutet [Stockholm], Faculty of Medicine, Palacky University Olomouc, Institute for Medical Informatics, Biometry, and Epidemiology, Universität Duisburg-Essen [Essen], Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Institute of Public Health, Cancer Care Ontario, Occupational Cancer Research Centre, Cancer Epidemiology Unit, Université de Turin, Institut Armand Frappier (INRS-IAF), Réseau International des Instituts Pasteur (RIIP)-Institut National de la Recherche Scientifique [Québec] (INRS), Bremen Institute for Prevention Research and Social Medicine, Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal (UdeM), Molecular Epidemiology of Cancer Unit, CIBER de Epidemiología y Salud Pública (CIBERESP), King‘s College London, Institute of Carcinogenesis, Russian Academy of Medical Sciences, Masaryk Memorial Cancer Institute (MMCI), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Universität Duisburg-Essen = University of Duisburg-Essen [Essen], Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Institut National de la Recherche Scientifique [Québec] (INRS)-Réseau International des Instituts Pasteur (RIIP)
Subjects: Pulmonary and Respiratory Medicine, Oncology, medicine.medical_specialty, [SDV]Life Sciences [q-bio], Medizin, Cumulative Exposure, lung neoplasms, Critical Care and Intensive Care Medicine, complex mixtures, 03 medical and health sciences, 0302 clinical medicine, Occupational Exposure, Diesel Exhaust, Lung Neoplasms, Epidemiology, Internal medicine, medicine, 030212 general & internal medicine, Lung cancer, Exposure assessment, business.industry, Case-control study, diesel exhaust, Odds ratio, occupational exposure, respiratory system, medicine.disease, Confidence interval, 3. Good health, respiratory tract diseases, 030228 respiratory system, Adenocarcinoma, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, epidemiology, business, human activities
Abstract: Rationale: Although the carcinogenicity of diesel engine exhaust has been demonstrated in multiple studies, little is known regarding exposure-response relationships associated with different exposure subgroups and different lung cancer subtypes.Objectives: We expanded on a previous pooled case-control analysis on diesel engine exhaust and lung cancer by including three additional studies and quantitative exposure assessment to evaluate lung cancer and subtype risks associated with occupational exposure to diesel exhaust characterized by elemental carbon (EC) concentrations.Methods: We used a quantitative EC job-exposure matrix for exposure assessment. Unconditional logistic regression models were used to calculate lung cancer odds ratios and 95% confidence intervals (CIs) associated with various metrics of EC exposure. Lung cancer excess lifetime risks (ELR) were calculated using life tables accounting for all-cause mortality. Additional stratified analyses by smoking history and lung cancer subtypes were performed in men.Measurements and Main Results: Our study included 16,901 lung cancer cases and 20,965 control subjects. In men, exposure response between EC and lung cancer was observed: odds ratios ranged from 1.09 (95% CI, 1.00-1.18) to 1.41 (95% CI, 1.30-1.52) for the lowest and highest cumulative exposure groups, respectively. EC-exposed men had elevated risks in all lung cancer subtypes investigated; associations were strongest for squamous and small cell carcinomas and weaker for adenocarcinoma. EC lung cancer exposure response was observed in men regardless of smoking history, including in never-smokers. ELR associated with 45 years of EC exposure at 50, 20, and 1 mu g/m(3) were 3.0%, 0.99%, and 0.04%, respectively, for both sexes combined.Conclusions: We observed a consistent exposure-response relationship betweenECexposure and lung cancer in men. Reduction of workplace EC levels to background environmental levels will further reduce lung cancer ELR in exposed workers.
Published: 2020

20. Psychosocial factors at work from the job strain model and preventable mortality in France: the STRESSJEM prospective study

Author: Anthony D. LaMontagne, Béatrice Geoffroy-Perez, Jean-François Chastang, Thomas Coutrot, Isabelle Niedhammer, Allison Milner, Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), University of Melbourne, Santé publique France - French National Public Health Agency [Saint-Maurice, France], Direction de l'animation de la recherche, des études et des statistiques (DARES), Ministère du Travail, de l'Emploi et de la Santé, EST-2016/1/49, Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail, Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Bertrais, Sandrine
Subjects: Male, Epidemiology, Cumulative Exposure, 01 natural sciences, High strain, 03 medical and health sciences, Social support, 0302 clinical medicine, Job stress, Risk Factors, Environmental health, Cumulative exposure, Humans, Medicine, Prospective Studies, 030212 general & internal medicine, 0101 mathematics, Workplace, Prospective cohort study, Aged, Proportional Hazards Models, Smoking-related mortality, External causes of death, Job strain, business.industry, Proportional hazards model, Preventable mortality, 010102 general mathematics, Public Health, Environmental and Occupational Health, Social Support, Psychosocial work factors, Work environment, 3. Good health, Occupational Diseases, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, 8. Economic growth, Alcohol-related mortality, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, business, Psychosocial, Stress, Psychological
Abstract: International audience; The study aimed to explore the prospective associations between psychosocial factors at work from the job strain model and preventable mortality, including smoking- and alcohol-related mortality as well as external causes of death. The study was based on prospective data and relied on a sample of 1,511,456 individuals for which data on job history, mortality and causes of death were linked over the 1976–2002 period. Exposures were the factors from the job strain model imputed through a job-exposure matrix. Various time-varying measures of exposure were used including current exposure and two measures of cumulative exposure. Preventable mortality was defined using the OECD/Eurostat list of preventable causes of death. The associations between exposures and outcomes were studied using Cox proportional hazards models. Effect modification by gender was also assessed. Over the study period, 57,264 preventable deaths occurred before the age of 75 years. Low decision latitude, low social support, job strain, iso-strain, passive job, and high strain were associated with preventable mortality, and associations of stronger magnitude were found for job strain and isostrain among men. Stronger associations were observed for alcohol-related mortality than for smoking-related mortality and external causes of death. The fractions of preventable mortality attributable to current exposure to job strain and isostrain were significant among men only (5.1% and 3.3%). Psychosocial factors at work from the job strain model may play a role on preventable mortality. Intensifying research and prevention towards the psychosocial work environment may be helpful to reduce risky health-related behaviours and related mortality.
Published: 2020

21. Associations between multiple occupational exposures and sleep problems: Results from the national French Working Conditions survey

Author: Sandrine Bertrais, Marilyne Bèque, Isabelle Niedhammer, Jean-François Chastang, Noëmie André, Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Direction de l'animation de la recherche, des études et des statistiques (DARES), Ministère du Travail, de l'Emploi et de la Santé, 2018/037, DARES of the French Ministry of Labour, Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Bertrais, Sandrine
Subjects: Adult, Male, Sleep Wake Disorders, Adolescent, Cognitive Neuroscience, insomnia symptoms, Young Adult, 03 medical and health sciences, Behavioral Neuroscience, symbols.namesake, 0302 clinical medicine, multiple exposures, Risk Factors, Occupational Exposure, Surveys and Questionnaires, Statistical significance, Environmental health, Prevalence, Humans, Medicine, occupational factors, Poisson regression, Workplace, Night work, Aged, job stress, business.industry, working conditions, General Medicine, Middle Aged, Working time, Sleep in non-human animals, Work environment, 030228 respiratory system, Physical work, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, 8. Economic growth, symbols, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Female, business, Psychosocial, 030217 neurology & neurosurgery
Abstract: International audience; Studies evaluating the effects of multiple occupational exposures on sleep are very rare. We assessed the associations between a wide range of occupational exposures and sleep problems, and investigated the cumulative effects of these exposures on this outcome. We used data from the French 2016 Working Conditions survey conducted on a nationally representative sample of workers, including 20430 employees aged 15-65 years (8579 men, 11851 women). Sleep problems were defined by either sleep disturbances or sleep medication, almost daily or several times a week. Occupational exposures included 21 psychosocial work factors grouped into 5 dimensions, 4 factors related to working time/hours and 4 factors related to the physical work environment. Unadjusted and adjusted weighted robust Poisson regression analyses were performed. Almost all psychosocial work exposures were associated with sleep problems, while the only significant working time/hours factor associated with sleep problems was night work among women. Some gender differences in the exposure-outcome associations were found. The prevalence ratio of sleep problems increased with the number of exposures for most dimensions of psychosocial work factors. Physical work exposures were associated with sleep problems, and there was a linear association between the number of these occupational exposures and sleep problems in both genders, although the trend did not reach statistical significance among women. Workplace preventive strategies targeting the work environment comprehensively may be effective to improve sleep among working populations. More attention should be given to multiple exposures at the workplace.
Published: 2020

22. Not just a research method: If used with caution, can job-exposure matrices be a useful tool in the practice of occupational medicine and public health?

Author: Johan Hviid Andersen, Alexis Descatha, Angelo d'Errico, Annette Leclerc, Bradley A. Evanoff, Marc Fadel, Ann Marie Dale, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Washington University in Saint Louis (WUSTL), University research clinic [Herning, Denmark], Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Paris (UP), Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Subjects: medicine.medical_specialty, Population level, occupational medicine, Job-exposure matrix, Method, Occupational safety and health, Occupational medicine, 03 medical and health sciences, 0302 clinical medicine, Environmental health, Occupational Exposure, medicine, Humans, Occupations, ComputingMilieux_MISCELLANEOUS, Research method, Exposure assessment, Public health, Occupational health, public health, Public Health, Environmental and Occupational Health, Methodology, Asbestos, methodology, tool, job-exposure matrix, 030210 environmental & occupational health, JEM, job exposure matrix, 3. Good health, occupational health, method, Tool, Job exposure matrix, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, Public aspects of medicine, RA1-1270, Psychology, Exposure data
Abstract: International audience; The recent editorial by Dr Susan Peters "Although a valuable method in occupational epidemiology, job-exposure matrices are no magic fix" ably describes the strengths and limitations of job-exposure matrix (JEM) approaches in occupational epidemiology research (1). In addition to their use in research, we would like to add that JEM may also be of use in compensation and surveillance efforts in occupational health. JEM could assist the compensation process by supporting the assessment of relevant exposures related to specific health conditions (2). The potential usefulness of a JEM as a decision tool for compensation of work-related musculoskeletal disorders has been examined (3). Because occupational diseases are often under-recognized, another practical application is using a JEM to screen for occupational exposures as part of health surveillance. Use of JEM to screen for asbestos and wood dust exposure in the clinical setting has shown promising results (4-6). By summarizing multiple exposures at a job level (7), JEM may also assist policy-makers in setting priorities for hazards and controls at work, as well as occupational practitioners to target prevention efforts and direct the conduct of more precise exposure measures to particular jobs. Sharing JEM across different countries may be useful in providing estimates of exposures across larger populations to calculate global burden of disease related to occupational exposure. The JEMINI (JEM InterNatIonal) initiative was launched to explore the possibility of developing international JEM that could be used across countries (8). Beginning with physical (biomechanical) exposures, this open group has started homogenizing job coding systems and comparing some available JEM. Estimating differences in the level of exposure between countries will require much more work, without guaranteed success. As Peters mentioned, many limitations exist in the use of JEM. Users of JEM must consider the source of exposure data - expert assessments, data collected from individual workers, or environmental sampling. The coding of occupations is time consuming and can introduce error (9), and more testing of and comparison with automated job coding systems is needed (10). JEM reflect an "average" level of exposure within a job at the expense of individual variation. At population level, JEM can offer a useful estimate of exposures. If used at an individual level in a clinical or compensation setting, JEM cannot replace the professionals involved in exposure assessment but may help them focus their action more effectively on complex situations that require their expertise. In conclusion, these JEM developed for research might also be used as a public health tool, provided that their limitations are properly taken into account. References 1. Peters S. Although a valuable method in occupational epidemiology, job-exposure matrices are no magic fix. Scand J Work Environ Health 2020;46:2314. https://doi-org.proxy.insermbiblio.inist.fr/10.5271/sjweh.3894 2. Kerbrat J, Descatha A. (The recognition of health consequences of difficult working conditions in France and its evaluation with the use of a job-exposure matrix). Arch Mal Prof Environ. 2018;79:493500. https://doi-org.proxy.insermbiblio.inist.fr/10.1016/j.admp.2017.12.001 3. Fadel M, Valter R, Quignette A, Descatha A. Usefulness of a job-exposure matrix « MADE » as a decision tool for compensation of work-related musculoskeletal disorders. Eur J Public Health 2019;29:86870. https://doi-org.proxy.insermbiblio.inist.fr/10.1093/eurpub/cky274 4. Lorentz E, Despreaux T, Quignette A, Chinet T, Descatha A. (Screening of occupational exposure to asbestos and silica by job-exposure matrix among patients with lung cancer and mesothelioma). Rev Mal Respir. 2019;36:108895. https://doi-org.proxy.insermbiblio.inist.fr/10.1016/j.rmr.2019.08.006 5. Imbernon E, Goldberg M, Spyckerell Y, Steinmetz J, Bonenfant S, Fournier B. (Use of a job-exposure matrix for the screening of occupational exposure to asbestos). Rev Epidemiol Sante Publique 2004;52:717. https://doi-org.proxy.insermbiblio.inist.fr/10.1016/S0398-7620(04)99018-9 6. Carton M, Bonnaud S, Nachtigal M, Serrano A, Carole C, Bonenfant S, et al. Post-retirement surveillance of workers exposed to asbestos or wood dust: first results of the French national SPIRALE Program. Epidemiol Prev. 2011;35:31523. 7. Guéguen A, Goldberg M, Bonenfant S, Martin JC. Using a representative sample of workers for constructing the SUMEX French general population based job-exposure matrix. Occup Environ Med. 2004;61:58693. https://doi-org.proxy.insermbiblio.inist.fr/10.1136/oem.2003.010660 8. Descatha A, Evanoff BA, Andersen JH, Fadel M, Ngabirano L, Leclerc A, et al. JEMINI (Job Exposure Matrix InterNatIonal) Initiative: a Utopian Possibility for Helping Occupational Exposure Assessment All Around the World? J Occup Environ Med. 2019;61:e3201. https://doi-org.proxy.insermbiblio.inist.fr/10.1097/JOM.0000000000001631 9. Petersen SB, Flachs EM, Svendsen SW, Marott JL, Budtz-Jørgensen E, Hansen J, et al. Influence of errors in job codes on job exposure matrix-based exposure assessment in the register-based occupational cohort DOC*X. Scand J Work Environ Health 2020;46:25967. https://doi-org.proxy.insermbiblio.inist.fr/10.5271/sjweh.3857 10. Buckner-Petty S, Dale AM, Evanoff BA. Efficiency of autocoding programs for converting job descriptors into standard occupational classification (SOC) codes. Am J Ind Med. 2019;62:5968. https://doi-org.proxy.insermbiblio.inist.fr/10.1002/ajim.22928.
Published: 2020

23. Shoulder pain among male industrial workers: Validation of a conceptual model in two independent French working populations

Author: Bodin, Julie, Garlantézec, Ronan, Costet, Nathalie, Descatha, Alexis, Viel, Jean-François, Roquelaure, Yves, Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), 9/25/2002-5, Public Health Agency, EST-2016/1/42, French National Research Program, IRSET - Épidémiologie en santé au travail et ergonomie (IRSET-ESTER), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), UMS011 Cohortes épidémiologiques en population (CONSTANCES), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Paris (UP), and Jonchère, Laurent
Subjects: Adult, Male, Work, Drug Industry, Shoulder pain, Risk Assessment, Structural equation model, Young Adult, Predictive Value of Tests, Humans, Industry, Workplace, Man-Machine Systems, ComputingMilieux_MISCELLANEOUS, Reproducibility of Results, Middle Aged, Models, Theoretical, Occupational exposure, Biomechanical Phenomena, Occupational Diseases, [STAT]Statistics [stat], Cross-Sectional Studies, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Arm, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Ergonomics, France
Abstract: This study aims to validate a conceptual model for shoulder pain risk factors in two independent samples of male industrial workers: the Cosali cohort (n = 334) and one pharmaceutical company (n = 487). Direct and indirect relationships between work organization factors (automatic speed of a machine or movement of a product and work pace dependent on customers' demand), psychosocial factors (Job strain model), biomechanical factors (working with abducted arms, working with arms at or above shoulder level, and perceived physical exertion), perceived stress, and shoulder pain were explored using structural equation models. Shoulder pain was positively associated with biomechanical exposure in both samples, and with perceived stress only in the pharmaceutical preparation manufacturer, while factors related to work organization and psychosocial factors had indirect impacts on the risk of chronic shoulder pain in both samples. The results provide a deeper understanding of the complex relationships between workplace risk factors and shoulder pain.
Published: 2020

24. Considering the challenge of the Covid-19 pandemic, is there a need to adapt the guidelines for basic life support resuscitation?

Author: Dominique Savary, Alexis Descatha, Marc Fadel, Francois Morin, Pierre Metton, Joseph Richard, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Hôpital Raymond Poincaré [AP-HP], CH Annecy Genevois, Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Bodin, Julie
Subjects: Adult, 2019-20 coronavirus outbreak, Resuscitation, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), medicine.medical_treatment, education, 030204 cardiovascular system & hematology, Emergency Nursing, Advanced Cardiac Life Support, Article, 03 medical and health sciences, 0302 clinical medicine, Pandemic, Medicine, Humans, Cardiopulmonary resuscitation, Child, health care economics and organizations, business.industry, Basic life support, 030208 emergency & critical care medicine, medicine.disease, Cardiopulmonary Resuscitation, 3. Good health, [STAT] Statistics [stat], Heart Arrest, Europe, [STAT]Statistics [stat], [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Emergency, Emergency Medicine, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Medical emergency, business, Cardiology and Cardiovascular Medicine, Coronavirus Infections, Algorithms, Defibrillators
Abstract: International audience; The world is facing a pandemic involving the Covid-19. One potential consequence of such crisis is the possibility of contamination of a bystander or a rescuer during resuscitation. Indeed, early cardiopulmonary resuscitation (CPR) is a key factor in out-of-hospital cardiac arrest (OHCA).
Published: 2020

25. Comparison Between a Job-Exposure Matrix (JEM) Score and Self-Reported Exposures for Carrying Heavy Loads Over the Working Lifetime in the CONSTANCES Cohort

Author: Alexis Descatha, Marc Fadel, Yves Roquelaure, Ann Marie Dale, Laure Ngabirano, Annette Leclerc, Bradley A. Evanoff, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), Division of General Medical Sciences, Washington University School of Medicine, Washington University in Saint Louis (WUSTL), Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), ANR-11-INBS-0002, Agence Nationale de la Recherche, AstraZeneca, Institut de Recherche en Santé Publique, CapaciT, Caisse nationale d’assurance maladie, Ministry of Research, Inserm-Transfert, ANR-11-INBS-0002,CONSTANCES,La cohorte CONSTANCES - Infrastructure épidémiologique ouverte pour la recherche et la surveillance(2011), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Santé publique et épidémiologie des déterminants professionnels et sociaux de la santé, Epidémiologie, sciences sociales, santé publique (IFR 69), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Fouquet, Natacha, and Infrastructures - La cohorte CONSTANCES - Infrastructure épidémiologique ouverte pour la recherche et la surveillance - - CONSTANCES2011 - ANR-11-INBS-0002 - INBS - VALID
Subjects: medicine.medical_specialty, exposure assessment, Job-exposure matrix, retrospective, Cumulative Exposure, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Occupational Exposure, Epidemiology, Medicine, Humans, 030212 general & internal medicine, biomechanical, Occupations, Exposure assessment, musculoskeletal, Receiver operating characteristic, business.industry, questionnaire, Public Health, Environmental and Occupational Health, job-exposure matrix, self-report, 030210 environmental & occupational health, Low back pain, Knee pain, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Cohort, Physical therapy, carrying heavy loads, epidemiology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Self Report, medicine.symptom, business, Low Back Pain
Abstract: Objectives Job-exposure matrices (JEMs) were developed to allow assessment of past work exposure for large population-based studies where better exposures data are unavailable. Few studies have directly compared biomechanical JEMs to self-administered questionnaires. We compared assessments of cumulative exposure to carrying heavy loads based on ‘JEM Constances’ to individually self-reported (SR) exposures. Methods In the French CONSTANCES cohort at inception, past SR exposure to carrying heavy loads (ever/never and durations) and a detailed job history were available for 26 929 subjects. JEM Constances, an existing biomechanical JEM based on SR current exposures from 26 821 asymptomatic workers, was combined with job history to build a cumulative biomechanical exposure score. Using individual SR exposure as the reference, Area Under the Curve (AUC) of Receiver Operating Characteristic (ROC) curves, sensitivity, and specificity were calculated. For both methods, associations with low back pain and knee pain were computed using multinomial logistic models. Additional analyses compared older (>10 years) to more recent (≤10 years) exposures. Results AUCs ranged from 0.795 (0.789–0.800) when all periods were considered, to 0.826 (0.820–0.833) for more recent biomechanical exposure (≤10 years). Associations between carrying heavy loads and low back pain or knee pain were less strong using JEM assessment than individually SR exposure: for low back pain ORSR = 3.02 (2.79–3.26) versus ORJEM = 1.70 (1.59–1.82) and for knee pain ORSR = 2.27 (2.10–2.46) versus ORJEM = 1.64 (1.53–1.77). Conclusions JEM Constances’ assessment of cumulative exposure of carrying heavy loads seems to be a useful method compared to a self-administrated questionnaire for large population-based studies where other methods are not available.
Published: 2020

26. Coronavirus outbreak: the role of companies in preparedness and responses

Author: Alexis Descatha, Jérôme Salomon, Marc Fadel, Fouquet, Natacha, Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Hôpital Raymond Poincaré [AP-HP], Pharmacoépidémiologie et maladies infectieuses (PhEMI), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Ministère des Solidarités et de la Santé [Paris, France], Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: medicine.medical_specialty, Pneumonia, Viral, MEDLINE, medicine.disease_cause, Global Health, Disease Outbreaks, 03 medical and health sciences, 0302 clinical medicine, Professional Role, medicine, Global health, Humans, 030212 general & internal medicine, Pandemics, ComputingMilieux_MISCELLANEOUS, Coronavirus, Viral Epidemiology, Public Health, Environmental and Occupational Health, Commerce, Outbreak, COVID-19, medicine.disease, 030210 environmental & occupational health, Pneumonia, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Preparedness, Emergency medicine, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Business, Coronavirus Infections
Abstract: International audience
Published: 2020
Full Text: View/download PDF

27. Critical review of the role of PPE in the prevention of risks related to agricultural pesticide use

Author: Garrigou, Alain, Laurent, Catherine, Berthet, Aurélie, Colosio, Claudio, Jas, Nathalie, Daubas-Letourneux, Véronique, Marçal, José, Filho, Jackson, Jouzel, Jean-Noël, Samuel, Onil, Baldi, Isabelle, Lebailly, Pierre, Galey, Louis, Goutille, Fabienne, Judon, Nathalie, Cancer environnement (EPICENE ), Bordeaux population health (BPH), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Université de Bordeaux (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Université de Bordeaux (UB), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université de Lausanne (UNIL), Università degli studi di Milano [Milano], Institut de Recherche Interdisciplinaire en Sciences Sociales (IRISSO), Université Paris Dauphine-PSL, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre de sociologie des organisations (CSO), Sciences Po (Sciences Po)-Centre National de la Recherche Scientifique (CNRS), Institut National de Santé Publique du Québec [Canada] (INSPQ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Université de Bordeaux (UB), Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers (ANTICIPE), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Recherche Agronomique (INRA), Institut National de la Recherche Agronomique (INRA)-Université Paris Dauphine-PSL, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), École des Hautes Études en Santé Publique [EHESP] (EHESP), Département Santé Environnement Travail et Génie Sanitaire (DSETGS), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-UNICANCER, Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Sciences pour l'Action et le Développement : Activités, Produits, Territoires (SADAPT), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université de Lausanne = University of Lausanne (UNIL), Università degli Studi di Milano-Bicocca = University of Milano-Bicocca (UNIMIB), Département des sciences humaines et sociales (SHS), Collectif de recherche handicap, autonomie et société inclusive (CoRHASI), Centre de Recherches sur l'Action Politique en Europe (ARENES), Université de Rennes (UR)-Institut d'Études Politiques [IEP] - Rennes-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Centre National de la Recherche Scientifique (CNRS), Fundacentro, Centre de sociologie des organisations (Sciences Po, CNRS) (CSO), Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM), Università degli Studi di Milano-Bicocca [Milano] (UNIMIB), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut d'Études Politiques [IEP] - Rennes-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Centre National de la Recherche Scientifique (CNRS), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Paris Dauphine-PSL, Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Régional de Lutte contre le Cancer François Baclesse (CRLC François Baclesse ), Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Sciences Po Institutional Repository, Spire, Université Paris Dauphine-PSL-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Centre Régional de Lutte contre le Cancer François Baclesse (CRLC François Baclesse ), and Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: [SDV]Life Sciences [q-bio], questions sanitaires, 0211 other engineering and technologies, Psychological intervention, équipement de protection, 02 engineering and technology, Field tests, Agricultural pesticides, Occupational safety and health, [SHS]Humanities and Social Sciences, Sécurité au travail, personal protective equipement, agriculture, pesticide, regulation, market authorisation, workers safety, équipement de protection individuel, autorisation de mise sur le marché, sécurité au travail, 021105 building & construction, [SDV.EE.SANT] Life Sciences [q-bio]/Ecology, environment/Health, 0501 psychology and cognitive sciences, Safety, Risk, Reliability and Quality, Market authorisation, 050107 human factors, Workers safety, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, Critical review, Personal protective equipement, 05 social sciences, Public Health, Environmental and Occupational Health, Authorization, EPICENE, Agriculture, Oecd countries, pesticides, Pesticide, Autorisation de mise sur le marché, Risk analysis (engineering), [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Safety Research, PPE, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [SHS] Humanities and Social Sciences, Business, Personal protection equipment, exposition, Regulation, Equipement de protection individuel
Abstract: publié en ligne 28 novembre 2019; International audience; Personal protection equipment (PPE) holds a privileged position in safety interventions in many countries, despite the fact that they should only be used as a last resort. This is even more paradoxical because many concerns have arisen as to their actual effectiveness under working conditions and their ability to provide the protection attributed to them by certain occupational safety strategies and marketing authorisation procedures. Are these concerns justified? This article is intended to provide an update on what we know of the issue based on a critical analysis of the literature to date.Analysis focuses on the assessment of the effectiveness of coveralls used to protect from plant protection products in OECD countries. All forms of assessment were retained: discussion of the observed effectiveness of PPE in relation to the underlying assumptions of marketing authorisation procedures, laboratory tests of equipment, practical field tests in which PPE-wearing practices were controlled and uncontrolled, analyses of the efficiency of preventive instructions based on wearing such coveralls.Findings show that recommending the use of PPE is key to the granting of marketing authorisation. Some dangerous products only get marketing authorisation because it is assumed that wearing PPE will considerably limit exposure. They would be banned if it were not for this assumption of protection. However the actual effectiveness of PPE in working conditions may be over-estimated. In addition many factors (cost, availability, thermic and mechanical discomfort) may make instructions to wear PPE inapplicable. Advising the use of PPE does not always mean effective protection.
Published: 2020

28. Factors associated with unmet need for limiting childbirth among women living with HIV in Togo: An averaging approach

Author: Bayaki Saka, Kanfitine Kolani, Mathias Kouamé N’dri, Abdoul-samadou Aboubakari, Aboubakari Nambiema, Akouda Patassi, Mawuényégan Kouamivi Agboyibor, Lihanimpo Djalogue, Takiyatou Baba-Toherou, Issifou Yaya, Sokhna Dieng, Dadja Essoya Landoh, Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Recherche pour le Développement (IRD), CHR Tomdè, Université de Lomé [Togo], World Health Organisation (WHO), country office of Togo, Clinique Biasa, Nambiema, Aboubakari, Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Subjects: RNA viruses, Epidemiology, Cross-sectional study, Maternal Health, Psychological intervention, HIV Infections, Pathology and Laboratory Medicine, Geographical Locations, Labor and Delivery, 0302 clinical medicine, Immunodeficiency Viruses, 5. Gender equality, Pregnancy, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Surveys and Questionnaires, Medicine and Health Sciences, Medicine, Childbirth, 030212 general & internal medicine, Contraception Behavior, Multidisciplinary, 030503 health policy & services, Pregnancy, Unplanned, Obstetrics and Gynecology, Middle Aged, 3. Good health, Contraception, Medical Microbiology, HIV epidemiology, HIV-positive women, Viral Pathogens, Togo, Viruses, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, symbols, Female, HIV clinical manifestations, Pathogens, 0305 other medical science, Research Article, Adult, Adolescent, Science, HIV prevention, unmet needs, [SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics, Microbiology, 03 medical and health sciences, symbols.namesake, Retroviruses, Humans, Female Contraception, Poisson regression, Family planning, Microbial Pathogens, Preventive medicine, business.industry, Lentivirus, Parturition, Organisms, Biology and Life Sciences, HIV, medicine.disease, Diagnostic medicine, [SDV.MHEP.GEO] Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics, Cross-Sectional Studies, Public and occupational health, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, People and Places, Africa, Birth, Life expectancy, Women's Health, Private healthcare, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Unintended pregnancy, Follow-Up Studies, Demography
Abstract: International audience; Background: Access to antiretroviral treatment has improved the life expectancy of HIV-positive patients, most often associated with a desire to limit childbearing. Women living with HIV (WLHIV) commonly have unmet need for contraception and could be at risk of unintended pregnancy. Preventing unintended pregnancies among women living with HIV are effective strategies to eliminate mother-to-child transmission of HIV. Objective: The aim of this study was to assess unmet need for limiting childbirth and its associated factors among women living with HIV in Togo. Methods: This facility based cross-sectional study was conducted, between June and August 2016, among WLHIV in their reproductive age (15–49 years) in HIV-care settings in Centrale and Kara regions Data was collected using a structured and pretested questionnaire. WLHIV who desired to limit childbirth but not using contraception were considered to have unmet need of birth limitations. Univariate and multivariate Poisson regression models with robust variance were performed to identify associated factors with unmet needs. A multi-model averaging approach was used to estimate the degree of the association between these factors and the unmet need of birth limitations. Results: A total of 443 WLHIV were enrolled, with mean age of 34.5 years (standard deviation [SD] = 7.0). Among them 244 (55.1%) were in couple and 200 (45.1%) had at least the secondary level of education. 39.1% were followed-up in a private healthcare facility. At the time of the survey, 40.0% did not desire childbearing but only 9.0% (95% CI [6.7–12.1]) of them expressed unmet needs for limiting childbirth. In multivariable analysis, associated factors with unmet needs of birth limitations were: being aged 35 years or more (adjusted prevalence ratio (aPR) = 3.11, 95% confidence intervals (95% CI) [1.52–6.38]), living in couple (aPR = 2.32 [1.15–4.65]), living in Kara region (aPR = 0.10 [0.01–0.76]), being followed in a private healthcare facility (aPR = 0.08[0.01–0.53]) and having severe HIV symptoms (aPR = 3.50 [1.31–9.37]). Conclusion: Even though the unmet need for births limitation was relatively low among WLHIV in Togo, interventions to improve more access to contraceptive methods, and targeting 35 to 49 years old women, those in couple or followed in the public healthcare facilities would contribute to the eradication of mother-to-child transmission of HIV.
Published: 2020

29. Applying two general population job exposure matrices to predict incident carpal tunnel syndrome: A cross-national approach to improve estimation of workplace physical exposures

Author: Alexis Descatha, Marcus Yung, Yves Roquelaure, Bradley A. Evanoff, Skye Buckner-Petty, Ann Marie Dale, Washington University in Saint Louis (WUSTL), Division of General Medical Sciences, Washington University School of Medicine, Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Hôpital Raymond Poincaré [Garches], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), and Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Male, assessment injury prevention, Binomial regression, Population, Job-exposure matrix, exposure–risk, occupational health, jem, Article, 03 medical and health sciences, 0302 clinical medicine, Musculoskeletal disorder, Occupational Exposure, Statistics, Medicine, Humans, musculoskeletal disorder, Prospective Studies, Occupations, education, cts, Workplace, ComputingMilieux_MISCELLANEOUS, Rank correlation, risk, Proportional Hazards Models, education.field_of_study, Proportional hazards model, business.industry, Hazard ratio, Public Health, Environmental and Occupational Health, physical exposure, prediction, medicine.disease, 030210 environmental & occupational health, job exposure matrix, incident carpal tunnel syndrome, workplace physical exposure, Carpal Tunnel Syndrome, msd, Occupational Diseases, ergonomics, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Akaike information criterion, Public aspects of medicine, RA1-1270, business
Abstract: International audience; Objectives A job exposure matrix (JEM) is a tool to estimate workers’ exposure to occupational physical risk factors. We evaluated the performance of two general population JEM (CONSTANCES and O*NET) to detect known exposure–disease relationships in an American prospective cohort study. We compared exposure estimates from three data sources and explored whether combining exposures from these two JEM, or combining exposure from each JEM with individual-level measures, improved prediction of carpal tunnel syndrome (CTS).Methods Using Cox proportional hazard models, we evaluated relationships between physical work exposure and incident CTS of 2393 workers using JEM-assigned and individual-level measure exposure information. We compared exposure estimates using Spearman’s rank correlation and Cohen’s kappa. We compared combined exposure models to single source exposure models by using binomial logistic regression and examined differences based on model fit and performance.Results The O*NET JEM [hazard ratio (HR) range 1.3–2.01] demonstrated generally similar exposure–disease associations as individual-level measures (HR range 1.00–1.42); we found fewer associations with the CONSTANCES JEM (HR range 1.08–2.05). Comparisons between the three sources showed stronger correlations and agreement at the job versus worker level. Combined models improved goodness-of-fit and had lower Akaike information criterion (AIC) values compared to single-source models.Conclusions JEM can be applied cross nationally and there is potential to combine complementary exposure methods to improve estimation of workplace physical exposures in the prediction of CTS. More investigations are needed to explore exposure-disease associations in other samples and combinations of exposure data from different methods.
Published: 2020

30. Upper-extremity musculoskeletal disorders: how many cases can be prevented? Estimates from the COSALI cohort

Author: Nambiema, Aboubakari, Bodin, Julie, Fouquet, Natacha, Bertrais, Sandrine, Stock, Susan, Aublet-Cuvelier, Agnès, Descatha, Alexis, Evanoff, Bradley, Roquelaure, Yves, Nambiema, Aboubakari, Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Santé publique France - French National Public Health Agency [Saint-Maurice, France], Institut national de santé publique du Québec, Laboratoire de Biomécanique et d'Ergonomie, Département Homme au Travail (HT), Institut national de recherche et de sécurité (Vandoeuvre lès Nancy) (INRS ( Vandoeuvre lès Nancy))-Institut national de recherche et de sécurité (Vandoeuvre lès Nancy) (INRS ( Vandoeuvre lès Nancy)), Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Division of General Medical Sciences, Washington University School of Medicine, This project was supported by Santé publique France, the French national public health agency, Saint-Maurice, France (Grant 9/25/2002–5 'réseau expérimental de surveillance des troubles musculo-squelettiques') and the French National Research Program for Environmental and Occupational Health of Anses (Grant EST-2016/1/42). None of the mentioned sources of funding had any role in the design, analysis or writing of this article., Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Subjects: Adult, Male, occupational risk factor, Cohort Studies, Upper Extremity, Young Adult, MSD, prevention, Risk Factors, preventable case, cohort study, Humans, musculoskeletal disorder, Musculoskeletal Diseases, physical exertion, upper-extremity musculoskeletal disorder, Middle Aged, COSALI, social support, Occupational Diseases, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, awkward shoulder posture, Original Article, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, Public aspects of medicine, RA1-1270, musculoskeletal disease
Abstract: International audience; Objective This study aimed to estimate the proportion and number of incident upper-extremity musculoskeletal disorders (UEMSD) cases attributable to occupational risk factors in a working population.Methods Between 2002−2005, occupational physicians randomly selected 3710 workers, aged 20–59, from the Pays de la Loire (PdL) region. All participants underwent a standardized clinical examination. Between 2007−2010, 1611 workers were re-examined. This study included 1246 workers who were free of six main clinically diagnosed UEMSD at baseline but were diagnosed with at least one of these UEMSD at follow-up [59% of men, mean age: 38 (standard deviation 8.6) years]. Relative risks and population-attributable fractions (PAF) were calculated using Cox multivariable models with equal follow-up time and robust variance. The total number of incident UEMSD in the PdL region was estimated after adjustment of the sample weights using 2007 census data. The estimated number of potentially avoidable UEMSD was calculated by multiplying PAF by the total number of incident UEMSD in PdL.Results At follow-up, 139 new cases of UEMSD (11% of the study sample) were diagnosed. This represented an estimated 129 320 incident cases in the PdL in 2007. Following adjustment for personal factors, 26 381 (20.4% of all incident UEMSD) were attributable to high physical exertion, 16 682 (12.9%) to low social support, and 8535 (6.6%) to working with arms above shoulder level.Conclusions A large number and important proportion of incident UEMSD may be preventable by reducing work exposures to physical exertion and working with arms above shoulder level as well as improving social support from co-workers/supervisors.
Published: 2020

31. The effect of exposure to long working hours on ischaemic heart disease A systematic review and meta-analysis from the WHO/ILO Joint Estimates of the Work-related Burden of Disease and Injury

Author: Tracey J. Woodruff, Daniela Vianna Pachito, Frank Pega, Hynek Pikhart, Reiner Rugulies, Alexis Descatha, Akizumi Tsutsumi, Rebecca L. Morgan, Bernd Richter, Peter L. Schnall, Jian Li, Maria-Inti Metzendorf, Paul Landsbergis, Chantal Brisson, Marco M Ferrario, Mattia Roncaioli, Johannes Siegrist, Sergio Iavicoli, Lode Godderis, Xavier Trudel, Grace Sembajwe, Yuka Ujita, Els Clays, University of California (UC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Centre de recherche du CHU Sainte-Justine / Research Center of the Sainte-Justine University Hospital [Montreal, Canada], Université de Montréal (UdeM)-CHU Sainte Justine [Montréal], Universiteit Gent = Ghent University (UGENT), Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Universitá degli Studi dell’Insubria = University of Insubria [Varese] (Uninsubria), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Istituto Nazionale per l’Assicurazione contro gli Infortuni sul Lavoro [Italian Workers Compensation Authority] (INAIL), State University of New York at Potsdam (SUNY Potsdam), State University of New York (SUNY), Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf], McMaster University [Hamilton, Ontario], Universidade Federal de São Paulo, University College of London [London] (UCL), University of Copenhagen = Københavns Universitet (UCPH), University of California [Irvine] (UC Irvine), City University of New York [New York] (CUNY), Kitasato University, University of California [San Francisco] (UC San Francisco), World Health Organization, 5NE11OH010461-03-00, National Institute for Occupational Safety and Health, Jonchère, Laurent, University of California, Centre de recherche du CHU Sainte-Justine [Montreal], CHU Sainte Justine [Montréal]-Université de Montréal (UdeM), Universiteit Gent = Ghent University [Belgium] (UGENT), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Paris (UP), University of Insubria, Varese, University of Copenhagen = Københavns Universitet (KU), University of California [Irvine] (UCI), University of California [San Francisco] (UCSF), and University of Dusseldorf
Subjects: PROTOCOL, Work, STRESS, 010504 meteorology & atmospheric sciences, EVIDENCE-BASED MEDICINE, [SDV]Life Sciences [q-bio], Myocardial Ischemia, 010501 environmental sciences, 01 natural sciences, law.invention, Randomized controlled trial, Cost of Illness, law, Medicine and Health Sciences, Medicine, Prospective Studies, Prospective cohort study, lcsh:Environmental sciences, General Environmental Science, lcsh:GE1-350, Ischaemic heart disease, 3. Good health, Europe, Occupational Diseases, [SDV] Life Sciences [q-bio], Systematic review, Long working hours, Meta-analysis, CARDIOVASCULAR-DISEASE, Female, HEALTH, Cohort study, ACUTE MYOCARDIAL-INFARCTION, Adolescent, World Health Organization, Work related, Article, RISK-FACTOR, Occupational Exposure, Humans, Risk factor, OVERTIME WORK, METAANALYSIS, 0105 earth and related environmental sciences, business.industry, Long working, SLEEP, Relative risk, business, Demography
Abstract: BACKGROUND: The World Health Organization (WHO) and the International Labour Organization (ILO) are developing Joint Estimates of the work-related burden of disease and injury (WHO/ILO Joint Estimates), with contributions from a large network of experts. Evidence from mechanistic data suggests that exposure to long working hours may cause ischaemic heart disease (IHD). In this paper, we present a systematic review and meta-analysis of parameters for estimating the number of deaths and disability-adjusted life years from IHD that are attributable to exposure to long working hours, for the development of the WHO/ILO Joint Estimates. OBJECTIVES: We aimed to systematically review and meta-analyse estimates of the effect of exposure to long working hours (three categories: 41-48, 49-54 and ≥55 h/week), compared with exposure to standard working hours (35-40 h/week), on IHD (three outcomes: prevalence, incidence and mortality). DATA SOURCES: We developed and published a protocol, applying the Navigation Guide as an organizing systematic review framework where feasible. We searched electronic databases for potentially relevant records from published and unpublished studies, including MEDLINE, Scopus, Web of Science, CISDOC, PsycINFO, and WHO ICTRP. We also searched grey literature databases, Internet search engines and organizational websites; hand-searched reference lists of previous systematic reviews; and consulted additional experts. STUDY ELIGIBILITY AND CRITERIA: We included working-age (≥15 years) workers in the formal and informal economy in any WHO and/or ILO Member State but excluded children (aged
Published: 2020

32. Cumulative Exposure to Long Working Hours and Occurrence of Ischemic Heart Disease Evidence From the CONSTANCES Cohort at Inception

Author: Fadel, Marc, Li, Jian, Sembajwe, Grace, Gagliardi, Diana, Pico, Fernando, Ozguler, Anna, Evanoff, Bradley A, Baer, Michel, Tsutsumi, Akizumi, Iavicoli, Sergio, Leclerc, Annette, Roquelaure, Yves, Siegrist, Johannes, Descatha, Alexis, Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Paris (UP), Hôpital Raymond Poincaré [AP-HP], University of California [Los Angeles] (UCLA), University of California, Washington University School of Medicine in St. Louis, Washington University in Saint Louis (WUSTL), Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), University of California (UC), and Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Subjects: Primary Prevention, Cohort Studies, cumulative exposure, Risk Factors, long working hours, [SDV]Life Sciences [q-bio], Myocardial Ischemia, Humans, Coronary Disease, epidemiology, Brief Communication, Lifestyle, ischemic heart disease
Abstract: International audience; Background Long-working hours (LWH) are a probable risk factor for ischemic heart diseases (IHD); however, no previous study has considered duration of exposure to LWH when addressing this topic. We aimed to determine the association between cumulative exposure to LWH and IHD while accounting for relevant confounders. Methods and Results In this retrospective study, we included all baseline participants from the French population-based cohort CONSTANCES. Part-time employees and those who reported a cardiac event in the 5 years before LWH exposure were excluded. From self-administered questionnaires and clinical examinations, we obtained participants' age, sex, body mass index, occupational status, smoking habits, high blood pressure, diabetes mellitus, familial history of cardiovascular disease, dyslipidemia, exposure to LWH, and its duration. We defined LWH as working for >10 hours daily for at least 50 days per year. The main outcome was reported history of IHD, ie, myocardial infarction or angina pectoris, during a clinical examination. Of 137 854 included participants, 69 774 were men. There were 1875 cases (1.36%) of IHD, and exposure to LWH was reported by 42 462 subjects (30.8%) among whom 14 474 (10.50%) reported exposure for at least 10 years. Overall, exposure to LWH for ≥10 years was associated with an increased risk of IHD, adjusted odds ratio (aOR) 1.24 (1.08-1.43), P=0.0021. In stratified analyses, this effect was not observed in women, but was significant amongst men, aOR 1.28 (1.11-1.48), P=0.0008. Conclusions This large population-based study supports an association between cumulative exposure to LWH and IHD in men. Future research should consider relevant strategies for reducing LWH exposure and duration.
Published: 2020

33. Ergonomics interventions to reduce musculoskeletal risk factors in a truck manufacturing plant

Author: Gilles Hunault, Jean-Claude Sagot, Yves Roquelaure, Nancy L. Black, Mohsen Zare, Edition, Littératures, Langages, Informatique, Arts, Didactique, Discours - UFC (UR 4661) (ELLIADD), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Moncton, Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques (HIFIH), Université d'Angers (UA), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), 2012/2/007, Environmental and Occupational Health of Anses (Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail, SCANIA Angers Production group, Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Edition, Littératures, Langages, Informatique, Arts, Didactique, Discours - UFC (EA 4661) (ELLIADD)
Subjects: Truck, 05 social sciences, Public Health, Environmental and Occupational Health, Stakeholder, Psychological intervention, Human factors and ergonomics, Automotive assembly plant, Human Factors and Ergonomics, Mean age, Organizational interventions, Context (language use), Engineering intervention, Musculoskeletal risk factors, 030210 environmental & occupational health, Work experience, [STAT]Statistics [stat], 03 medical and health sciences, 0302 clinical medicine, 0501 psychology and cognitive sciences, Operations management, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Organizational changing, Psychology, 050107 human factors
Abstract: International audience; Ergonomic interventions may potentially reduce MSDs, but the context of industries (barriers, ever-changing situations, dialogue processes) might play a significant role in the success of interventions. This study evaluates the effectiveness of ergonomic interventions including engineering/technical and organizational interventions, and the involvement of the stakeholders in reducing musculoskeletal risk factors/symptoms. A pre-post-test experimental study in non-randomized groups was performed over three years in a sector of a truck assembly plant. The mean age of the operators in the sector for the initial and second assessment time was 42.0 (±7.6) years and 39.0 (±8.7), respectively. The mean length of work experience in the current job was 15.2 (±7.2) years and 13.9 (±7.3) for the initial and second assessment times, respectively. Five engineering ergonomic solutions and organizational interventions were implemented after a comprehensive ergonomic analysis. The organizational interventions consisted mostly of transferring and redistributing the tasks, i.e., ergonomically balancing and redesigning of the workstations. Before performing the interventions, the findings of the ergonomic study were presented at several meetings to encourage the involvement of the stakeholders (including managers, engineers, and operators) in the interventions. This study showed that a combination of ergonomic measures—engineering and organizational interventions—could reduce physical workloads. Musculoskeletal symptoms decreased after interventions although the difference was not significant.
Published: 2020

34. RoB-SPEO: A tool for assessing risk of bias in studies estimating the prevalence of exposure to occupational risk factors from the WHO/ILO Joint Estimates of the Work-related Burden of Disease and Injury

Author: Daniele Mandrioli, Susan L Norris, Kathrine Sørensen, Tracey J. Woodruff, Alexis Descatha, Tom Loney, Denise Torreão Corrêa da Silva, Patrice Sutton, Lisa Bero, Emilie van Deventer, Marília Silva Paulo, Vivi Schlünssen, Paul T.J. Scheepers, Ellen K. Silbergeld, Rebecca L. Morgan, Daria Sgargi, Diana Gagliardi, Frank Pega, Lode Godderis, Daniela Vianna Pachito, Thomas Tenkate, Yuka Ujita, Claudine Backes, Alberto Modenese, Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Paris (UP), Department of Public Health [Copenhagen, Denmark] (Danish Ramazzini Centre), Aarhus University [Aarhus]-The National Research Center for Work Environment [Copenhagen, Denmark], Johns Hopkins University (JHU), Department of Obstetrics, Gynecology and Reproductive Sciences, University of California [San Francisco] (UCSF), University of California-University of California, 1 E11 OH0010676-02, World Health Organization, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), UMS011 Cohortes épidémiologiques en population (CONSTANCES), Unité de pathologie professionnelle, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Raymond Poincaré [AP-HP], IRSET - Épidémiologie en santé au travail et ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Aarhus University [Copenhagen, Denmark]-The National Research Center for Work Environment [Copenhagen, Denmark]
Subjects: Burden of disease, PROTOCOL, Blinding, 010504 meteorology & atmospheric sciences, Occupational risk, MEDLINE, Environmental Sciences & Ecology, 010501 environmental sciences, World Health Organization, 01 natural sciences, Work related, Article, Occupational safety and health, Bias, Risk Factors, Environmental health, Occupational Exposure, Prevalence, Humans, lcsh:Environmental sciences, 0105 earth and related environmental sciences, General Environmental Science, lcsh:GE1-350, Science & Technology, Other Research Radboud Institute for Health Sciences [Radboudumc 0], Conflict of interest, SCIENCE, 3. Good health, Occupational Diseases, SYSTEMATIC REVIEWS, Systematic review, ASSESSMENTS, Wounds and Injuries, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Psychology, Life Sciences & Biomedicine, Environmental Sciences
Abstract: Background The World Health Organization (WHO) and the International Labour Organization (ILO) are developing joint estimates of the work-related burden of disease and injury (WHO/ILO Joint Estimates). For this, systematic reviews of studies estimating the prevalence of exposure to selected occupational risk factors will be conducted to provide input data for estimations of the number of exposed workers. A critical part of systematic review methods is to assess risk of bias (RoB) of individual studies. In this article, we present and describe the development of such a tool, called the Risk of Bias in Studies estimating Prevalence of Exposure to Occupational risk factors (RoB-SPEO) tool; report results from RoB-SPEO's pilot testing; note RoB-SPEO's limitations; and suggest how the tool might be tested and developed further. Methods Selected existing RoB tools used in environmental and occupational health systematic reviews were reviewed and analysed. From existing tools, we identified domains for the new tool and, if necessary, added new domains. For each domain, we then identified and integrated components from the existing tools (i.e. instructions, domains, guiding questions, considerations, ratings and rating criteria), and, if necessary, we developed new components. Finally, we elicited feedback from other systematic review methodologists and exposure scientists and agreed upon RoB-SPEO. Nine experts pilot tested RoB-SPEO, and we calculated a raw measure of inter-rater agreement (Pi) for each of its domain, rating Pi 0.80 as almost perfect agreement. Results Our review found no standard tool for assessing RoB in prevalence studies of exposure to occupational risk factors. We identified six existing tools for environmental and occupational health systematic reviews and found that their components for assessing RoB differ considerably. With the new RoB-SPEO tool, assessors judge RoB for each of eight domains: (1) bias in selection of participants into the study; (2) bias due to a lack of blinding of study personnel; (3) bias due to exposure misclassification; (4) bias due to incomplete exposure data; (5) bias due to conflict of interest; (6) bias due to selective reporting of exposures; (7) bias due to difference in numerator and denominator; and (8) other bias. The RoB-SPEO's ratings are low, probably low, probably high, high or no information. Pilot testing of the RoB-SPEO tool found substantial inter-rater agreement for six domains (range of Pi for these domains: 0.51–0.80), but poor agreement for two domains (i.e. Pi of 0.31 and 0.33 for biases due to incomplete exposure data and in selection of participants into the study, respectively). Limitations of RoB-SPEO include that it has not yet been fully performance-tested. Conclusions We developed the RoB-SPEO tool for assessing RoB in prevalence studies of exposure to occupational risk factors. The tool will be applied and its performance tested in the ongoing systematic reviews for the WHO/ILO Joint Estimates., Highlights • WHO and ILO are systematically reviewing occupational exposure prevalence studies. • Assessing risk of bias (RoB) in individual studies is a core step of systematic reviews. • We developed RoB-SPEO, a tool to assess RoB in occupational exposure prevalence studies. • The performance of RoB-SPEO will be tested in the WHO/ILO systematic reviews.
Published: 2020

35. Working conditions in the explanation of occupational inequalities in sickness absence in the French SUMER study

Author: Sarah Memmi, Jean-François Chastang, Thomas Lesuffleur, Isabelle Niedhammer, Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Direction de l'animation de la recherche, des études et des statistiques (DARES), Ministère du Travail, de l'Emploi et de la Santé, French ministry of labour (DARES) [2200684049], and Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Subjects: Male, Pediatrics, medicine.medical_specialty, Cross-sectional study, Shift work, 03 medical and health sciences, Social support, 0302 clinical medicine, Occupational Exposure, Environmental health, Absenteeism, medicine, Humans, Psychology, Social inequality, 030212 general & internal medicine, Workplace, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, Job strain, Workplace violence, business.industry, Public Health, Environmental and Occupational Health, Social Support, Health Status Disparities, 030210 environmental & occupational health, Cross-Sectional Studies, 8. Economic growth, Female, France, business, Psychosocial
Abstract: International audience; Background - Explanations of social inequalities in sickness absence are lacking in the literature. Our objectives were to evaluate the contribution of various occupational exposures in explaining these inequalities in a national representative sample of employees. Methods - The study was based on the cross-sectional sample of the SUMER 2010 survey that included 46 962 employees, 26 883 men and 20 079 women. Both sickness absence spells and days within the last 12 months, as health indicators, were studied. Occupation was used as a marker of social position. The study included both psychosocial work factors (variables related to the classical job strain model, psychological demands, decision latitude, social support and understudied variables related to reward, job insecurity, job promotion, esteem, working time/hours and workplace violence) and occupational exposures of chemical, biological, physical and biomechanical nature. Weighted age-adjusted Poisson and negative binomial regression analyses were performed. Results - Strong occupational differences were found for sickness absence spells and days and for exposure to most work factors. Psychosocial work factors contributed to explain occupational differences in sickness absence spells, and the contributing factors were: decision latitude, social support, reward, shift work and workplace violence. Physical exposure, particularly noise, and biomechanical exposure were also found to be contributing factors. Almost no work factor was found to contribute to occupational differences in sickness absence days. Conclusion - Preventive measures at the workplace oriented towards low-skilled occupational groups and both psychosocial work factors and other occupational exposures may be beneficial to reduce sickness absence spells and occupational differences in this outcome.
Published: 2017

36. Low Control and High Demands at Work as Risk Factors for Suicide: An Australian National Population-Level Case-Control Study

Author: Jane Pirkis, Allison Milner, Isabelle Niedhammer, Jean-François Chastang, Matthew J Spittal, Anthony D. LaMontagne, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Deakin University [Burwood], University of Melbourne, Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Subjects: Adult, Employment, Male, Gerontology, Adolescent, Job control, Poison control, Suicide prevention, Odds, Young Adult, 03 medical and health sciences, Sex Factors, 0302 clinical medicine, Risk Factors, Cause of Death, Humans, Medicine, Registries, 030212 general & internal medicine, Risk factor, Applied Psychology, business.industry, Australia, Odds ratio, Middle Aged, 030210 environmental & occupational health, 3. Good health, Suicide, Psychiatry and Mental health, Case-Control Studies, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Psychosocial, Stress, Psychological, Cohort study, Demography
Abstract: International audience; Objective - Previous research suggests that psychosocial job stressors may be plausible risk factors for suicide. This study assessed the relationship between psychosocial job stressors and suicide mortality across the Australian population. Methods - We developed a job exposure matrix to objectively measure job stressors across the working population. Suicide data came from a nationwide coronial register. Living controls were selected from a nationally representative cohort study. Incidence density sampling was used to ensure that controls were sampled at the time of death of each case. The period of observation for both cases and controls was 2001 to 2012. We used multilevel logistic regression to assess the odds of suicide in relation to 2 psychosocial job stressors (job control and job demands), after matching for age, sex, and year of death/survey and adjusting for socioeconomic status. Results - Across 9,010 cases and 14,007 matched controls, our results suggest that low job control (odds ratio [OR], 1.35; 95% confidence interval [CI], 1.26-1.44; p < .001) and high job demands (OR, 1.36; 95% CI, 1.26-1.46; p < .001) were associated with increased odds of male suicide after adjusting for socioeconomic status. High demands were associated with lower odds of female suicide (OR, 0.81; 95% CI, 0.72-0.92; p = .002). Conclusions - It seems that adverse experiences at work are a risk factor for male suicide while not being associated with an elevated risk among females. Future studies on job stressors and suicide are needed, both to further understand the biobehavioral mechanisms explaining the link between job stress and suicide, and to inform targeted prevention initiatives.
Published: 2017

37. Job strain as a risk factor for clinical depression: systematic review and meta-analysis with additional individual participant data

Author: Jaana Pentti, Archana Singh-Manoux, Peter Westerholm, Salla Toppinen-Tanner, Hugo Westerlund, Lars Alfredsson, Maria Nordin, Markku Koskenvuo, Anders Knutsson, Aki Koskinen, Marianna Virtanen, Jane E. Ferrie, Sakari Suominen, J.-F. Chastang, Jan H. Pejtersen, Martin L. Nielsen, M. Borritz, Paula Salo, Inger Plaisier, M. ten Have, Mika Kivimäki, Jussi Vahtera, Katriina Heikkilä, Eleonor I. Fransson, Nico Dragano, Constanze Leineweber, Ari Väänänen, G. D. Batty, T. Theorell, L. L. Magnusson Hanson, Mark Hamer, Reiner Rugulies, Tuula Oksanen, Solja T. Nyberg, Hermann Burr, Kirsi Ahola, Markus Jokela, R. de Graaf, Ida E. H. Madsen, Jakob B. Bjorner, I. Niedhammer, Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Danish Working Environment Research Fund, UK Medical Research Council [K013351], Economic and Social Research Council, European Union NEW OSH ERA research programme, Finnish Work Environment Fund, Swedish Research Council for Working Life and Social Research, German Social Accident Insurance, Academy of Finland and NordForsk, Nordic Programme on Health and Welfare [75021], Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)
Subjects: medicine.medical_specialty, Review Article, Psykiatri, Occupational Stress, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Health Sciences, medicine, Psychology, Humans, 030212 general & internal medicine, Risk factor, Observational studies, observational studies, Applied Psychology, Depression (differential diagnoses), Psychiatry, Depressive Disorder, Psykologi, Job strain, business.industry, Hälsovetenskaper, work stress, 030210 environmental & occupational health, Confidence interval, Psychiatry and Mental health, Relative risk, Meta-analysis, occupational health, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Psychosocial, Clinical psychology, Cohort study
Abstract: BackgroundAdverse psychosocial working environments characterized by job strain (the combination of high demands and low control at work) are associated with an increased risk of depressive symptoms among employees, but evidence on clinically diagnosed depression is scarce. We examined job strain as a risk factor for clinical depression.MethodWe identified published cohort studies from a systematic literature search in PubMed and PsycNET and obtained 14 cohort studies with unpublished individual-level data from the Individual-Participant-Data Meta-analysis in Working Populations (IPD-Work) Consortium. Summary estimates of the association were obtained using random-effects models. Individual-level data analyses were based on a pre-published study protocol.ResultsWe included six published studies with a total of 27 461 individuals and 914 incident cases of clinical depression. From unpublished datasets we included 120 221 individuals and 982 first episodes of hospital-treated clinical depression. Job strain was associated with an increased risk of clinical depression in both published [relative risk (RR) = 1.77, 95% confidence interval (CI) 1.47–2.13] and unpublished datasets (RR = 1.27, 95% CI 1.04–1.55). Further individual participant analyses showed a similar association across sociodemographic subgroups and after excluding individuals with baseline somatic disease. The association was unchanged when excluding individuals with baseline depressive symptoms (RR = 1.25, 95% CI 0.94–1.65), but attenuated on adjustment for a continuous depressive symptoms score (RR = 1.03, 95% CI 0.81–1.32).ConclusionsJob strain may precipitate clinical depression among employees. Future intervention studies should test whether job strain is a modifiable risk factor for depression.
Published: 2017

38. Occupational co‐exposure to biomechanical factors and neurotoxic chemicals in a representative sample of French employees

Author: Thi-Hai-Yen Nguyen, Nathalie Bonvallot, Mélanie Bertin, Yves Roquelaure, Julie Bodin, Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), French National Research Program for Environmental and Occupational Health of Anses [EST-2014/1/077], Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Subjects: Adult, Male, Neurotoxins, Occupational physicians, 03 medical and health sciences, 0302 clinical medicine, multiple exposures, Surveys and Questionnaires, Environmental health, Prevalence, medicine, Humans, Working population, Musculoskeletal Diseases, Carpal tunnel syndrome, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, business.industry, Brief Report, Public Health, Environmental and Occupational Health, occupational exposure, medicine.disease, 030210 environmental & occupational health, Biomechanical Phenomena, neurotoxic chemicals, Occupational Diseases, Cross-Sectional Studies, biomechanical factors, Brief Reports, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, Occupational exposure, Co exposure, business, 030217 neurology & neurosurgery, Peripheral nerve damage
Abstract: International audience; Objectives: Musculoskeletal disorders, mainly carpal tunnel syndrome, represent a leading cause of compensation claims of workers worldwide. Despite this, and the fact that occupational exposures to biomechanical factors and neurotoxic chemicals have been individually associated with peripheral nerve damage, the prevalence of occupational co-exposure to biomechanical factors and neurotoxic chemicals has rarely been explored. Therefore, our aim was to assess the prevalence of occupational co-exposure to biomechanical factors and neurotoxic chemicals in a national representative sample of the French working population.Methods: The study was based on the French representative cross-sectional survey SUMER 2010. A total of 47 983 employees who had worked in their current job for at least one year were included. Occupational exposure to biomechanical factors and neurotoxic chemicals within the previous week of work were assessed using a questionnaire during face-to-face interviews with occupational physicians.Results: Approximately 5% of male employees and 1% of female employees were co-exposed to biomechanical factors and neurotoxic chemicals. This prevalence was up to 10% among male blue-collar workers and 13%, 8%, and 6%, respectively, among male employees in the construction, agriculture, and industry sectors. Male employees under 30 years old, in apprenticeships, and working in small companies were more co-exposed to biomechanical factors and neurotoxic chemicals than their counterparts.Conclusions: Occupational co-exposure to biomechanical factors and neurotoxic chemicals was observed in a significant proportion of French male employees, suggesting that further studies are required to investigate its potential adverse effects on peripheral neuropathies.
Published: 2019

39. Factors associated with physiotherapy prescription among adult patients consulting for musculoskeletal disorders in primary care

Author: PEUROIS, Matthieu, Ramond-Roquin, Aline, Adjeroud, Najia, Bertin, Mélanie, Fouquet, Natacha, Roquelaure, Yves, Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Santé publique France - French National Public Health Agency [Saint-Maurice, France], Fouquet, Natacha, Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and École des Hautes Études en Santé Publique [EHESP] (EHESP)
Subjects: [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, multilevel analysis, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Primary care, Physiotherapy, Musculoskeletal disorders
Abstract: International audience; Learning objectives - On completion of this session, participants should be able to identify factors associated with physiotherapy prescription for patients consulting for musculoskeletal disorder (MSD) in primary care.- On completion of this session, participants should be aware to the interest of using a multilevel approach in primary care epidemiology. Context MSDs are a frequent reason for encounter in general practitioners (GPs) consultations. Their management is based on a bio-psycho-social approach, including sometimes physiotherapy prescription (PP). Physiotherapy is mainly initiated by GPs but little is known about the factors associated with PP during consultations related to MSDs.ObjectiveTo evaluate the factors associated with general practitioners’ physiotherapy prescription among adult patients consulting for musculoskeletal disorders (MSDs). Human subjects review The ECOGEN study was approved by ethical comity (CPP Sud-Est IV L11-149, 10/11/2011). Design this study is based on the French observational cross-sectional ECOGEN study carried out in 2011/2012 among 128 GPs. Setting Patients and physicians characteristics, consultation results and healthcare procedures were systematically collected using International Classification of Primary Care (ICPC-2). Analyses focused on patients aged between 18 and 65 years-old consulting their GP for any MSD in primary care. Main and secondary outcome measures Prevalence of PP was first assessed, then the factors associated with PP were explored using an adjusted multilevel (patient / physician / geographical area) logistic model. Hierarchical ascending classification (HAC) was used to identify patient profiles. Anticipated results Among the 2305 patients included, 456 (19.8%) were prescribed physiotherapy. Following multivariate multilevel analyses, PP was more frequent for female patients (OR 1.28; 1.03-1.59) and among patients with spinal (OR 1.47; 1.18-1.83) and cuff rotator tendinitis-related (OR 1.66; 1.20-2.29) disorders. PP was less frequent for patients older than 50 years-old (OR 0.69; 0.52-0.91) having more than 3 healthcare procedures prescribed during the consultation, when GPs were older than 50 years-old (OR 0.50; 0.39-0.63), had a high activity level (OR 0.79; 0.63-0.99), practice in semi-urban area (OR 0.62; 0.42-0.90) in multidisciplinary team (OR 0.62; 0.43-0.90) and when patients lived in precarious geographical area (OR 0.60; 0.40-0.90). Seven clinically sound patient clusters were identified by HAC. Conclusion This multilevel analysis show differences in rate of physiotherapy prescription for MSD patients consulting for MSD, particularly physician’s related factors and potential territorial disparities, which should be considered in a health inequalities reduction approach.
Published: 2019

40. Troubles musculo-squelettiques du membre supérieur : combien de cas peuvent être évités ? Estimations à partir de la cohorte Cosali pour la région des Pays de la Loire

Author: Julie Bodin, Susan Stock, Sandrine Bertrais, Natacha Fouquet, Agnès Aublet-Cuvelier, Bradley A. Evanoff, Aboubakari Nambiema, Yves Roquelaure, Alexis Descatha, Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Santé publique France - French National Public Health Agency [Saint-Maurice, France], Département Homme au Travail (HT), Institut national de recherche et de sécurité (Vandoeuvre lès Nancy) (INRS ( Vandoeuvre lès Nancy)), This project was supported by Santé publique France, the French national public health agency, Saint-Maurice, France (Grant 9/25/2002–5 'réseau expérimental de surveillance des troubles musculo-squelettiques') and the French National Research Program for Environmental and Occupational Health of Anses (Grant EST-2016/1/42)., Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Nambiema, Aboubakari
Subjects: 030506 rehabilitation, 03 medical and health sciences, 0302 clinical medicine, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Public Health, Environmental and Occupational Health, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, 0305 other medical science, 030210 environmental & occupational health
Abstract: International audience; RésuméObjectifsEstimer la proportion et le nombre de cas de troubles musculo-squelettiques du membre supérieur (TMS-MS) théoriquement évitables dans la région des Pays de la Loire (PdL).Méthodes3 710 salariés de la région des PdL ont été inclus par tirage au sort dans la cohorte Cosali entre 2002 et 2005 par des médecins du travail de la région. Les participants ont bénéficié d’un examen clinique standardisé selon le consensus européen Saltsa recherchant six types de TMS-MS. Les données sur les caractéristiques personnelles et les conditions de travail ont été recueillies au moyen d’un auto-questionnaire. Entre 2007 et 2010, 1 611 salariés ont été réexaminés par leur médecin du travail. Seuls les salariés indemnes de TMS-MS à l’inclusion ont été inclus dans cette étude (734 hommes et 512 femmes, âgés de 20 à 54 ans). Les fractions de TMS-MS attribuables (FRA) aux facteurs de risque ont été estimées à partir de modèles logistiques multivariés. Le nombre total de TMS-MS à l’échelle régionale a été estimé après redressement par repondération des individus de l’échantillon sur les données du recensement 2007. Le nombre de TMS-MS évitables a été obtenu en multipliant la FRA par le nombre de TMS-MS estimé à l’échelle de la région.RésultatsAu suivi, 74 (10 %) de cas de TMS-MS chez les hommes et 65 (13 %) chez les femmes ont été diagnostiqués. Les facteurs professionnels associés aux TMS-MS dans les modèles de régression logistique sont : intensité élevée des efforts physiques perçus (RPE de Borg ≥ 12) et un faible soutien social chez les hommes, et travail avec un ou deux bras écartés du corps régulièrement ou de manière prolongée chez les femmes. Chez les hommes, 55 % des TMS-MS sont attribuables à l’intensité élevée des efforts physiques perçus soit 35 000 cas potentiellement évitables à l’échelle de la région et 17 % (10 000 cas évitables) des TMS-MS sont attribuables au faible soutien social. Chez les femmes, 20 % (14 000 cas évitables) des TMS-MS sont attribuables au travail avec les bras écartés du corps régulièrement ou de manière prolongée.ConclusionsUne part importante des TMS-MS dans la région des PdL pourrait être évitée en réduisant les expositions professionnelles telles que l’intensité élevée des efforts physiques, le travail avec les bras écartés du corps et en améliorant le soutien social au travail. Ces résultats permettent d’estimer le nombre de TMS-MS évitables pour de futures actions ciblées de prévention à l’échelle de la région étudiée.
Published: 2019

41. Lifetime Duration of Exposure to Biomechanical Factors at Work as a Mediator of the Relationship Between Socioeconomic Position and Walking Speed

Author: Angelo d'Errico, Fulvio Ricceri, Alexis Descatha, Annette Leclerc, Yves Roquelaure, Marcel Goldberg, Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Università degli studi di Torino = University of Turin (UNITO), Université d'Angers (UA), UMS 011, Institut National de la Santé et de la Recherche Médicale (INSERM), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), UFR Médecine [Santé] - Université Paris Cité (UFR Médecine UPCité), and Université Paris Cité (UPCité)
Subjects: Male, Mediation (statistics), Walking, walking speed, 03 medical and health sciences, symbols.namesake, 0302 clinical medicine, work, Medicine, Humans, 030212 general & internal medicine, Poisson regression, Occupations, mediation analysis, Socioeconomic status, Exercise, Aged, Original Research, business.industry, lcsh:Public aspects of medicine, 030503 health policy & services, Work (physics), Public Health, Environmental and Occupational Health, Human factors and ergonomics, lcsh:RA1-1270, Regression analysis, socioeconomic position, ergonomics, Middle Aged, Preferred walking speed, Cross-Sectional Studies, Cohort, symbols, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Female, Public Health, 0305 other medical science, business, Demography
Abstract: International audience; The study aimed to assess the proportion mediated by the duration of exposure to ergonomic factors at work on the relationship between socioeconomic position (SEP) and low walking speed. This cross-sectional study was performed on data collected at baseline on 19,704 men and 20,273 women 45-70 years old, currently or previously employed, enrolled in the Constances cohort. SEP was assigned through current or last occupation, categorized in three classes, based on the European Socioeconomic Classification. Walking speed was assessed through one measurement of normal walking for 3 m and dichotomized at the lowest quintile of the sex- and age- (5-year) specific distribution. Self-reported workplace exposure throughout working life to repetitive work, intense physical work, and lifting/carrying heavy loads was used to assess the duration of exposure to each factor, categorized in four classes. Through Poisson regression models, adjusted for BMI, smoking, alcohol intake, hypertension, physical activity, diabetes, cardiovascular diseases, and a cognitive score, the attenuation in the prevalence ratio (PR) of low walking speed by SEP produced by the inclusion of duration of exposure to each factor was evaluated. The mediating effect of work ergonomic exposures on the relationship between SEP and low walking speed was assessed using the weighted method by Vanderweele. In the fully adjusted model without ergonomic exposures, both men and women in the middle and the lowest SEP had a significantly increased risk of low walking speed compared with those in the highest SEP (men: PR = 1.30 and PR = 1.46, respectively; women: PR = 1.24 and PR = 1.45, respectively). The inclusion in separate regression models of exposure duration to repetitive work, intense physical work, and handling of heavy loads produced modest risk attenuations in both men and women, all smaller or around 10%. Mediation analysis revealed in both sexes significant mediation effects for most ergonomic exposures considered, although also with low mediation effects. Significant differences in walking speed by SEP were observed in this large sample, but the proportion of such differences explained by the duration of exposure to ergonomic factors at work was low using either the risk attenuation or the mediation analysis methods.
Published: 2019

42. T Cell Dysregulation in Non-silicotic Silica Exposed Workers: A Step Toward Immune Tolerance Breakdown

Author: Brilland, B, Beauvillain, C, Mazurkiewicz, G, Rucay, P, Roquelaure, Yves, Tabiasco, J, Vinatier, E, Riou, J, Jeannin, P, Renier, G, Subra, Jf, Augusto, Jf, Service de Néphrologie-Dialyse-Transplantation, CHU d'Angers, Innate Immunity and Immunotherapy (CRCINA-ÉQUIPE 7), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), Laboratoire d'Immunologie et d'Allergologie, CHU d'Angers, Service Santé au Travail Côte de Lumière, Service de Médecine du Travail, CHU d'Angers, Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Micro et Nanomédecines Translationnelles (MINT), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Jonchère, Laurent, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Subjects: Adult, Male, Time Factors, Immunology, HLA-DR Antigens, crystalline silica, Middle Aged, Silicon Dioxide, T-Lymphocytes, Regulatory, regulatory T cells, Autoimmune Diseases, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, occupational diseases, auto-antibodies, Antibodies, Antinuclear, Occupational Exposure, Immune Tolerance, Immunology and Allergy, Humans, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, auto-immune diseases, Prospective Studies, Original Research, activated T cells
Abstract: International audience; Background: Chronic silica exposure can lead to silicosis, complicated or not by autoimmune diseases (AID). The pathophysiology of silica-induced AID remains not fully understood, especially immune mechanisms that may develop in patients without yet established silicosis. We conducted a prospective clinical study to analyze the impact of crystalline silica (CS) on T cell phenotype and regulatory T cells (Tregs) frequency, as well as on auto-antibodies development in non-silicotic workers exposed to CS.Methods: Workers with moderate to high exposure level to CS and aged between 30 and 60 years-old were considered for inclusion. Peripheral blood mononuclear cells were analyzed by flow cytometry. Auto-antibodies were screened in serum by immunofluorescence. Blood from 42 and 45 healthy subjects (HC) was used as control for T cell phenotype and serum analyses, respectively.Results: Among the 63 included workers exposed to CS, 55 had full data available and were analyzed. Ten were exposed to CS for
Published: 2019

43. Alcohol, tobacco and cannabis use are associated with job loss at follow-up: Findings from the CONSTANCES cohort

Author: Guillaume Airagnes, Cédric Lemogne, Pierre Meneton, Marie Plessz, Marcel Goldberg, Nicolas Hoertel, Yves Roquelaure, Frédéric Limosin, Marie Zins, Department of Psychiatry and Addictology [Paris], Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Université Paris Descartes - Faculté de Médecine (UPD5 Médecine), Université Paris Descartes - Paris 5 (UPD5), Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Psychiatrie et Neurosciences (U894), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire d'Informatique Médicale et Ingénierie des Connaissances en e-Santé (LIMICS), Université Paris 13 (UP13)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), The CONSTANCES cohort is supported by the Caisse Nationale d’Assurance Maladie des travailleurs salariés-CNAMTS. CONSTANCES is accredited as a 'National Infrastructure for Biology and health' by the governmental Investissements d’avenir program and was funded by the Agence nationale de la recherche (ANR-11-INBS-0002 Grant). CONSTANCES also receives funding from MSD, AstraZeneca and Lundbeck managed by INSERM-Transfert. This study has received a funding from the Interministerial Mission for Combating Drugs and Addictive Behaviors ('Mission Interministérielle de Lutte contre les Drogues et les Conduites Addictives', MILDECA)., ANR-11-INBS-0002,CONSTANCES,La cohorte CONSTANCES - Infrastructure épidémiologique ouverte pour la recherche et la surveillance(2011), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Paris (UP), Institut de psychiatrie et neurosciences (U894 / UMS 1266), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Bodescot, Myriam, and Infrastructures - La cohorte CONSTANCES - Infrastructure épidémiologique ouverte pour la recherche et la surveillance - - CONSTANCES2011 - ANR-11-INBS-0002 - INBS - VALID
Subjects: Male, Economics, [SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Social Sciences, Cohort Studies, Tobacco Use, Habits, Sociology, Medicine and Health Sciences, Smoking Habits, Psychology, Public and Occupational Health, Alcohol Consumption, Depression, Middle Aged, Socioeconomic Aspects of Health, [SDV.TOX] Life Sciences [q-bio]/Toxicology, Behavioral Pharmacology, [SDV.TOX]Life Sciences [q-bio]/Toxicology, Medicine, Female, Marijuana Use, France, Research Article, Adult, Employment, Alcohol Drinking, Science, Jobs, Education, Young Adult, Recreational Drug Use, Mental Health and Psychiatry, Humans, Educational Attainment, Cannabis, Nutrition, Pharmacology, Behavior, Mood Disorders, Biology and Life Sciences, Diet, Health Care, Unemployment, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Labor Economics, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Follow-Up Studies
Abstract: International audience; BACKGROUND:Substance use is more prevalent among unemployed subjects compared to employed ones. However, quantifying the risk subsequent of job loss at short-term according to substance use remains underexplored as well as examining if this association persist across various sociodemographic and occupational positions previously linked to job loss. We examined this issue prospectively for alcohol, tobacco, cannabis use and their combination, among a large population-based sample of men and women, while taking into account age, gender, overall health status and depressive symptoms.METHODS:From the French population-based CONSTANCES cohort, 18,879 working participants were included between 2012 and 2016. At baseline, alcohol use disorder risk according to the Alcohol Use Disorders Identification Test (mild, dangerous, problematic or dependence), tobacco (non-smoker, former smoker, 1-9, 10-19, >19 cigarettes/day) and cannabis use (never, not in past year, less than once a month, once a month or more) were assessed. Employment status at one-year (working versus not working) was the dependent variable. Logistic regressions provided Odds Ratios(OR(95%CI)) of job loss at one-year, adjusting for age, gender, self-reported health and depressive state (measured with the Center of Epidemiologic Studies Depression scale). Stratified analyses were performed for education, occupational grade, household income, job stress (measured with the Effort-Reward Imbalance), type of job contract, type of work time and history of unemployment. In sensitivity analyses, employment status over a three-year follow-up was used as dependent variable.RESULTS:Alcohol, tobacco and cannabis use were associated with job loss, from the second to the highest category: 1.46(95%CI:1.23-1.73) to 1.92(95%CI:1.34-2.75), 1.26(95%CI:1.09-1.46) to 1.78(95%CI:1.26-2.54) and 1.45(95%CI:1.27-1.66) to 2.68(95%CI:2.10-3.42), respectively, and with dose-dependent relationships (all p for trend
Published: 2019

44. Personal, biomechanical, psychosocial and organizational risk factors for carpal tunnel syndrome: a Structural Equation Modelling Approach

Author: Ronan Garlantézec, Alexis Descatha, Jean Baptiste Fassier, Julie Bodin, Bradley A. Evanoff, Yves Roquelaure, Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), Washington University in Saint Louis (WUSTL), Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement (UMRESTTE UMR T9405), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR), Rubion, Elise, IRSET - Épidémiologie en santé au travail et ergonomie (IRSET-ESTER), and Washington University in St Louis
Subjects: Male, Longitudinal study, medicine.medical_specialty, [SDV]Life Sciences [q-bio], Wrist, Structural equation modeling, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, 030202 anesthesiology, Humans, Medicine, Longitudinal Studies, Carpal tunnel syndrome, ComputingMilieux_MISCELLANEOUS, Job strain, business.industry, medicine.disease, Carpal Tunnel Syndrome, Latent class model, nervous system diseases, Occupational Diseases, Anesthesiology and Pain Medicine, medicine.anatomical_structure, Neurology, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Latent Class Analysis, Cohort, Physical therapy, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Neurology (clinical), business, Psychosocial, 030217 neurology & neurosurgery
Abstract: International audience; This longitudinal study aimed at exploring the direct and indirect relationships between organizational, psychosocial, biomechanical, and personal factors and carpal tunnel syndrome (CTS) in French workers. Between 2002 and 2005, 3710 workers were included in the Cosali cohort. Between 2007 and 2010, 1611 workers were re-examined using the same standardized clinical protocol. Subjects free from CTS at baseline were studied (804 men and 563 women). We used structural equation models to examine the relationships between incident CTS cases and organizational (machine-paced work or work pace dependent on customers' demand), psychosocial (job strain model), biomechanical (Borg's rating perceived exertion, wrist bending, pinching, and hand-transmitted vibrations), and personal factors at baseline. Symptomatic CTS risk was directly increased by biomechanical factors (standardized coefficient = 0.19, P = 0.011), female gender (0.25, P < 0.001), and age (0.15, P = 0.042). No psychosocial factors had a direct impact on CTS, but decision authority and skill discretion had an indirect impact by influencing biomechanical exposure. Exposure to machine-paced work had an indirect impact on increasing CTS, either by raising biomechanical exposure (0.19, P < 0.001) or by lowering decision authority (-0.18, P < 0.001) and skill discretion (-0.20, P < 0.001), which in turn increased biomechanical exposure. Similar complex relationships were observed between risk factors and CTS defined by a more strict case definition. Biomechanical exposure had a direct impact on CTS, while organizational factors and psychosocial factors had an indirect impact on CTS. The findings support conceptual models linking work organization to CTS.
Published: 2019

45. Prevalence of prescribed benzodiazepine long-term use in the French general population according to sociodemographic and clinical factors: findings from the CONSTANCES cohort

Author: Airagnes, Guillaume, Lemogne, Cedric, Renuy, Adeline, Goldberg, Marcel, Hoertel, Nicolas, Roquelaure, Yves, Limosin, Frédéric, Zins, Marie, Department of Psychiatry and Addictology [Paris], Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Université Paris Descartes - Faculté de Médecine (UPD5 Médecine), Université Paris Descartes - Paris 5 (UPD5), Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Ambulatoire d'Addictologie [Paris], Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Centre de Psychiatrie et Neurosciences (U894), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), CONSTANCES is accredited as a 'National Infrastructure for Biology and health' by the governmental Investissements d’avenir program and was funded by the Agence nationale de la recherche (ANR-11-INBS-0002 Grant). CONSTANCES also receives funding from MSD, AstraZeneca and Lundbeck managed by INSERM-Transfert. This study has received a funding from the Interministerial Mission for Combating Drugs and Addictive Behaviors ('Mission Interministérielle de Lutte contre les Drogues et les Conduites Addictives', MILDECA)., ANR-11-INBS-0002,CONSTANCES,La cohorte CONSTANCES - Infrastructure épidémiologique ouverte pour la recherche et la surveillance(2011), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Paris (UP), Institut de psychiatrie et neurosciences (U894 / UMS 1266), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Bodescot, Myriam, and Infrastructures - La cohorte CONSTANCES - Infrastructure épidémiologique ouverte pour la recherche et la surveillance - - CONSTANCES2011 - ANR-11-INBS-0002 - INBS - VALID
Subjects: Adult, Employment, Male, Long-term use, Time Factors, Misuse, [SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Administrative registries, Drug Prescriptions, Cohort Studies, Benzodiazepines, Odds Ratio, Prevalence, Humans, Registries, Aged, Benzodiazepine, Marital Status, Depression, lcsh:Public aspects of medicine, lcsh:RA1-1270, General population, Sociodemographic factors, Middle Aged, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, [SDV.SP] Life Sciences [q-bio]/Pharmaceutical sciences, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, French national cohort, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Insurance, Health, Reimbursement, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, Alcohol use, Research Article
Abstract: Background Data are lacking regarding the prevalence of benzodiazepine long-term use in the general population. Our aim was to examine the prevalence of prescribed benzodiazepine long-term use (BLTU) according to sociodemographic and clinical factors in the French general population. Methods Data came from 4686 men and 4849 women included in 2015 in the French population-based CONSTANCES cohort. BLTU was examined using drug reimbursement administrative registries from 2009 to 2015. Analyses were weighted to provide results representative of the French general population covered by the general health insurance scheme. Weighted prevalence of BTLU and weighted Odds Ratios (OR) of having BTLU were computed with their 95% Confidence Interval (95% CI) according to age, education level, occupational status, occupational grade, household income, marital status, alcohol use disorder risk and depressive symptoms. All the analyses were stratified for gender. Results Weighted prevalence of BLTU were 2.8%(95% CI:2.3–3.4) and 3.8%(95% CI: 3.3–4.5) in men and women, respectively. Compared to men, women had an increased risk of having benzodiazepine long-term use with OR = 1.34(95% CI = 1.02–1.76). Aging, low education, not being at-work, low occupational grade, low income, being alone and depressive state were associated with increased risks of having BTLU. Conclusions BLTU is widespread in the French general population, however this issue may particularly concern vulnerable subgroups. These findings may help in raising attention on this public health burden as well as targeting specific at-risk subgroups in preventive intervention. Electronic supplementary material The online version of this article (10.1186/s12889-019-6933-8) contains supplementary material, which is available to authorized users.
Published: 2019

46. Burnout et lombalgies chroniques liées au travail : l’importance des dimensions interpersonnelles comme facteurs de risque

Author: Margaux Le Borgne, Yves Roquelaure, Abdel Halim Boudoukha, Christine Jeoffrion, Audrey Petit, Laboratoire de Psychologie des Pays de la Loire (LPPL), Université d'Angers (UA)-Université de Nantes - UFR Lettres et Langages (UFRLL), Université de Nantes (UN)-Université de Nantes (UN), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and CCSD, Accord Elsevier
Subjects: [SDV]Life Sciences [q-bio], Santé au travail, Lombalgie chronique, [SDV] Life Sciences [q-bio], 03 medical and health sciences, Psychiatry and Mental health, 0302 clinical medicine, Facteurs de risque, Arts and Humanities (miscellaneous), Burnout, Croyances peur-évitement, 030212 general & internal medicine, 030217 neurology & neurosurgery, Applied Psychology
Abstract: National audience; Cette étude vise à étudier les liens entre burnout, douleur et incapacité au sein d’une population de 256 travailleurs lombalgiques chroniques. Différents questionnaires validés en langue française ont été utilisés pour mesurer l’intensité douloureuse, les répercussions fonctionnelles, le burnout, les croyances peur-évitement et le catastrophisme. Les résultats montrent que les croyances peur-évitement liées au travail ont un fort poids prédictif, avec un effet positif significatif sur les variables. Les différentes dimensions du burnout sont liées aux variables relatives à la douleur et à l’incapacité, l’épuisement émotionnel permet d’expliquer 3 à 16 % de la variance de l’intensité douloureuse et des répercussions fonctionnelles (p < ,01). Cette étude confirme le rôle des croyances dans le développement et le maintien de la lombalgie chronique et met en avant le fait que le burnout serait un facteur de risque à l’augmentation des douleurs et l’incapacité. La prise en compte des dimensions interpersonnelles liées au travail s’avère nécessaire afin de mieux comprendre ce phénomène complexe de la douleur chronique liée au travail.
Published: 2019

47. Theoretical Impact of Workplace-Based Primary Prevention of Lumbar Disc Surgery in a French Region: A Pilot Study

Author: Audrey Petit, Descatha A, Yves Roquelaure, Natacha Fouquet, Santé publique France - French National Public Health Agency [Saint-Maurice, France], Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Bagnara S., Tartaglia R., Albolino S., Alexander T., Fujita Y., Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Bodin, Julie, Bagnara S., Tartaglia R., Albolino S., Alexander T., Fujita Y., Rubion, Elise, Université d'Angers (UA), Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Paris (UP), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité)
Subjects: Male, Lumbar disc-related disorders, Psychological intervention, Pilot Projects, Neurosurgical Procedures, 0302 clinical medicine, Promotion (rank), Risk Factors, attributable risk, Medicine, Food service, 030212 general & internal medicine, Workplace, ComputingMilieux_MISCELLANEOUS, media_common, Incidence (epidemiology), Rehabilitation, Middle Aged, preventive efficiency, simulation, 3. Good health, Primary Prevention, [STAT]Statistics [stat], Population Surveillance, Female, France, Intervertebral Disc Displacement, Adult, Occupational risk, media_common.quotation_subject, work-related, Work related, 03 medical and health sciences, Risk-Taking, Lumbar disc surgery, Primary prevention, Environmental health, Hospital discharge, Humans, 030203 arthritis & rheumatology, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, business.industry, Public Health, Environmental and Occupational Health, Occupational Injuries, [STAT] Statistics [stat], [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Attributable risk, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Low Back Pain, 030217 neurology & neurosurgery
Abstract: International audience; BACKGROUND Lumbar disc-related disorders are a main cause of work-related osteo-articular morbidity. Lumbar disc surgery (LDS) has been chosen as sentinel event for the epidemiological surveillance of these disorders since LDS can be identified in the medical databases from public and private hospitals. OBJECTIVE To assess the theoretical impact of workplace-based primary interventions designed to reduce exposure to personal and/or work-related risk factors for LDS. METHODS Cases of LDS were assessed using hospital discharge records for persons aged 20-64 in 2007-8 in the French Pays de la Loire region. We estimated the number of work-related cases of LDS (WR-LDS) in high-risk industry sectors. Three theoretical scenarios of workplace-based primary prevention have been simulated a mono-component work-centered intervention reducing the incidence of WR-LDS by 10%, and two multicomponent global interventions reducing the incidence of all cases of LDS by 5% and 10% by targeting personal and occupational risk factors. RESULTS Four high-risk sectors were identified, amounting to 277 [216-352] cases, of which 98 [37-175] were WR-LDS construction and information and communication for men; wholesale and retail trade and accommodation and food service activities for women. AFE was limited for each industry sector, 30%, 50%, 33% and 55%, respectively. CONCLUSIONS Prevention scenarios combining actions on personal and occupational risk factors would be the most effective, compared to prevention focused only on occupational risk factors. Implementing actions of promotion of health at work would be necessary in addition of actions on occupational risks.
Published: 2019

48. Chronic dietary exposure to pesticide residues and associated risk in the French ELFE cohort of pregnant women

Author: Blandine de Lauzon-Guillain, Véronique Sirot, Marion Hulin, Alexandre Nougadère, Erwan de Gavelle, Cécile Chevrier, Marie-Aline Charles, Mathilde Merlo, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Agence Nationale de Sécurité Sanitaire, de l'Alimentation, de l'environnement et du Travail ( ANSES ), ANSES - Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail ( ANSES ), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité ( CRESS (U1153 / UMR_A 1125) ), Université Sorbonne Paris Cité ( USPC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Institut National de la Recherche Agronomique ( INRA ), Institut de recherche, santé, environnement et travail ( Irset ), Université d'Angers ( UA ) -Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -École des Hautes Études en Santé Publique [EHESP] ( EHESP ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) -Université des Antilles ( UA ), Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC), and Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Subjects: Adult, Piperonyl butoxide, Insecticides, Adolescent, [SDV]Life Sciences [q-bio], Food Contamination, 010501 environmental sciences, 01 natural sciences, Propargite, Risk Assessment, Dietary exposure, Toxicology, Cohort Studies, 03 medical and health sciences, chemistry.chemical_compound, Young Adult, 0302 clinical medicine, Pregnancy, Medicine, Humans, 030212 general & internal medicine, lcsh:Environmental sciences, 0105 earth and related environmental sciences, General Environmental Science, 2. Zero hunger, lcsh:GE1-350, Pesticide residues, Pesticide residue, [ SDV ] Life Sciences [q-bio], business.industry, Pregnant women, Risk characterization, Pesticide, medicine.disease, 3. Good health, chemistry, Chlorpyrifos, Cohort, Female, France, Cumulative risk assessment, French ELFE cohort, business, Risk assessment
Abstract: Dietary exposure to pesticide residues may present a risk to public health, especially for sensitive populations such as pregnant women. To characterize this risk, this study assessed chronic dietary exposure to pesticide residues based on the French ELFE cohort. A self-administered food frequency questionnaire (FFQ) about the last three months of pregnancy filled in by pregnant women in 2011 was used in combination with occurrence data from French Total Diet Studies completed by the results of national monitoring programs on pesticide residues in food. The dietary intake of pesticides (μg/kg of body weight/day) was estimated for 14,099 pregnant women with a complete FFQ, for 317 substances under two occurrence scenarios to handle left-censored data: a lower-bound scenario (LB), where undetected results were set to zero, and an upper-bound scenario (UB), where undetected results were set to the detection limit if the substance was expected to be found in food and zero if it was not. The risk was assessed for 284 substances with a toxicological reference value (TRV) and a good coverage level of the diet potentially contributing to pesticide intake. The cumulative risk was also assessed for seven effects on nervous and thyroid systems using the hazard index and the Cumulative Assessment Groups defined by EFSA. Substances with the highest exposure levels under the LB scenario were, in decreasing order, imazalil, piperonyl butoxide, chlorpropham, thiabendazole, iprodione and propargite. Under the LB scenario, only for lindane did women have a statistically significant probability of exceeding the TRV (2.4%). Under the UB scenario, risk could not be excluded for nine other substances. A better management of left-censored data and more sensitive analyses of the main food contributors might help to refine the UB exposure and risk assessments. A statistically significant cumulative risk was found for neurochemical effects related to high intake levels of three organophosphate insecticides (chlorpyrifos, pirimiphos-methyl and dimethoate) mainly detected in fruits and cereals. Keywords: Pesticide residues, Dietary exposure, Pregnant women, French ELFE cohort, Risk characterization, Cumulative risk assessment
Published: 2016

49. Chronic hepatitis E in HIV/HBV coinfected patient

Author: Sophie Demeret, Vincent Mallet, Thierry Poynard, Valérie Pourcher, Anne-Marie Roque-Afonso, Gilles Peytavin, Christine Katlama, Ruxandra Calin, Sepideh Akhavan, Vincent Thibault, Eve Todesco, Marie Jaspard, Institut Pierre Louis d'Epidémiologie et de Santé Publique ( iPLESP ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ), Service de Virologie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Pitié-Salpêtrière [APHP], Service de Réanimation Neurologique [CHU Pitié-Salpêtrière], Service des maladies infectieuses et tropicales [CHU Pitié-Salpêtrière], Pathogénèse et traitement de l'hépatite fulminante et du cancer du foie, Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Physiopathologie et traitement des maladies du foie, Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -AP-HP Hôpital Paul Brousse, CHU Pontchaillou [Rennes], Institut de recherche, santé, environnement et travail ( Irset ), Université d'Angers ( UA ) -Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -École des Hautes Études en Santé Publique [EHESP] ( EHESP ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) -Université des Antilles ( UA ), Service d'hépatologie médicale [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Cochin [AP-HP], Institut Pasteur [Paris], Centre d'Immunologie Humaine ( CIH ), Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Service de virologie, Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Pitié-Salpêtrière [APHP], Centre d'Immunologie et de Maladies Infectieuses ( CIMI ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ), Infection, Antimicrobiens, Modélisation, Evolution ( IAME ), Université Paris 13 ( UP13 ) -Université Paris Diderot - Paris 7 ( UPD7 ) -Université Sorbonne Paris Cité ( USPC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Pharmacologie et toxicologie [AP-HP Hôpital Bichat-Claude-Bernard], AP-HP - Hôpital Bichat - Claude Bernard [Paris]-Université Paris Diderot - Paris 7 ( UPD7 ), Service d'Hépato-Gastroentérologie [CHU Pitié-Salpêtrière], Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition ( ICAN ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -CHU Pitié-Salpêtrière [APHP], Service des maladies infectieuses [CHU Pitié-Salêtrière], Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut Pasteur [Paris] (IP), Centre d'Immunologie Humaine (CIH), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d'Immunologie et de Maladies Infectieuses (CIMI), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Service de virologie [CHU Pitié-Salpêtrière], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Neurologie [CHU Pitié-Salpêtrière], IFR70-CHU Pitié-Salpêtrière [AP-HP], Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Paul Brousse-Université Paris-Sud - Paris 11 (UP11), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service d'Hépato-Gastro-Entérologie [CHU Pitié-Salpêtrière], Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC), Service de Maladies Infectieuses et Tropicales [CHU Pitié-Salpêtrière], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
Subjects: Male, 0301 basic medicine, Sofosbuvir, Immunology, Human immunodeficiency virus (HIV), HIV Infections, medicine.disease_cause, Antiviral Agents, Treatment failure, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Ribavirin, Hepatitis E virus, medicine, Humans, Immunology and Allergy, Treatment Failure, Chronic hepatitis E, ComputingMilieux_MISCELLANEOUS, Hepatitis, Chronic, Hepatitis, Coinfection, business.industry, Alanine Transaminase, [ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie, Middle Aged, Viral Load, Hepatitis B, medicine.disease, Virology, Hepatitis E, 3. Good health, 030104 developmental biology, Infectious Diseases, chemistry, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, 030211 gastroenterology & hepatology, business, Viral load, medicine.drug
Abstract: International audience; no abstract
Published: 2017

50. Nickel and associated metals in New Caledonia Exposure levels and their determinants

Author: Sylvaine Cordier, Yannick Dominique, Audray St-Jean, Barbara Le Bot, Yann Barguil, Pierre Ayotte, Université Laval [Québec] (ULaval), CHU de Québec–Université Laval, Centre hospitalier territorial Gaston-Bourret [Nouméa], Bioeko [Nouméa, Nouvelle-Calédonie], Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), CNRT (CSF) [4PS2013-CNRT.INSERM/METEXPO], Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Jonchère, Laurent, Université Laval, Institut de recherche, santé, environnement et travail ( Irset ), Université d'Angers ( UA ) -Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -École des Hautes Études en Santé Publique [EHESP] ( EHESP ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) -Université des Antilles ( UA ), and École des Hautes Études en Santé Publique [EHESP] ( EHESP )
Subjects: Adult, inorganic chemicals, Chromium, 010504 meteorology & atmospheric sciences, [ SDV.TOX ] Life Sciences [q-bio]/Toxicology, chemistry.chemical_element, Urine, 010501 environmental sciences, 01 natural sciences, Soil, [ SDV.BBM.BC ] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM], New Caledonia, Ultramafic rock, Nickel, Environmental health, Biomonitoring, Humans, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Child, [SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], lcsh:Environmental sciences, 0105 earth and related environmental sciences, General Environmental Science, lcsh:GE1-350, geography, Manganese, geography.geographical_feature_category, Dust, [ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie, Environmental Exposure, Cobalt, Contamination, [SDV.TOX] Life Sciences [q-bio]/Toxicology, chemistry, Metals, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Reference values, [SDV.TOX]Life Sciences [q-bio]/Toxicology, Archipelago, Environmental science, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Environmental Monitoring
Abstract: The ultramafic massifs of the New Caledonian archipelago contain about 10% of the world's nickel reserves, which also contain significant but lower amounts of cobalt, chromium, and manganese. Natural erosion of these massifs and mining activities may contribute to the exposure of local populations to these metals through contamination of air, food, and water resources. We conducted a biomonitoring survey to evaluate exposure to these four metals and its main determinants by constructing a stratified sample of 732 adults and children (>3 years old) from visitors to 22 health centers across the archipelago. Urine was collected and analyzed by inductively-coupled plasma mass spectrometry to determine metal concentrations. A face-to-face interview was conducted to document sociodemographic characteristics, lifestyle and dietary habits, and residence-mine distance. Environmental samples (soil, house dust, water, and foodstuffs) were collected from two areas (one with and one without mining activity) to delineate determinants of exposure in more detail. Nickel and chromium were metals with the highest concentrations found in urine, especially in children, at levels exceeding reference values derived from representative national surveys elsewhere throughout the world (for children: 4.7 μg/g creatinine for nickel and 0.50 μg/g creatinine for chromium): 13% of children exceeded the reference value for nickel and 90% for chromium. Large variations were observed by region, age, and sex. In this geological setting, urinary and environmental nickel concentrations appear to be driven mainly by soil content. This is the first archipelago-wide survey of metal exposure in New Caledonia. The potential health consequences of this chronic high exposure need to be assessed. Keywords: New Caledonia, Biomonitoring, Nickel, Chromium, Cobalt, Manganese
Published: 2018

Catalog

Books, media, physical & digital resources

See catalog results

Searchworks

Select search scope, currently: Articles Catalog books, media & more in Jio Institute collections Articles journal articles & other e-resources

Search

Search Constraints

Refine your results

Search Limiters

Topic

Publication Year Range

Language

Journal

Database

Publisher

1,482 results on '"Université d'Angers (UA)-Université de Rennes 1 (UR1)"'

Search Results

Catalog

Select search scope, currently: Articles

Catalog

books, media & more in Jio Institute collections

Articles

journal articles & other e-resources