263 results on '"Turville, Stuart"'
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2. SARS-CoV-2 Omicron variant escapes neutralizing antibodies and T cell responses more efficiently than other variants in mild COVID-19 convalescents
- Author
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Garcia-Valtanen, Pablo, Hope, Christopher M, Masavuli, Makutiro G, Yeow, Arthur Eng Lip, Balachandran, Harikrishnan, Mekonnen, Zelalem A, Al-Delfi, Zahraa, Abayasingam, Arunasingam, Agapiou, David, Stella, Alberto Ospina, Aggarwal, Anupriya, Bouras, George, Gummow, Jason, Ferguson, Catherine, O’Connor, Stephanie, McCartney, Erin M, Lynn, David J, Maddern, Guy, Gowans, Eric J, Reddi, Benjamin AJ, Shaw, David, Kok-Lim, Chuan, Beard, Michael R, Weiskopf, Daniela, Sette, Alessandro, Turville, Stuart G, Bull, Rowena A, Barry, Simon C, and Grubor-Bauk, Branka
- Subjects
Infectious Diseases ,Pneumonia & Influenza ,Pneumonia ,Prevention ,Biodefense ,Lung ,Immunization ,Vaccine Related ,Emerging Infectious Diseases ,Infection ,Good Health and Well Being ,Antibodies ,Neutralizing ,Antibodies ,Viral ,COVID-19 ,Humans ,Reinfection ,SARS-CoV-2 ,Spike Glycoprotein ,Coronavirus ,T-Lymphocytes ,T cell immunity ,Variant of Concern ,antibody response ,antigen drift ,memory B cells ,virus neutralization - Abstract
Coronavirus disease 2019 (COVID-19) convalescents living in regions with low vaccination rates rely on post-infection immunity for protection against re-infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We evaluate humoral and T cell immunity against five variants of concern (VOCs) in mild-COVID-19 convalescents at 12 months after infection with ancestral virus. In this cohort, ancestral, receptor-binding domain (RBD)-specific antibody and circulating memory B cell levels are conserved in most individuals, and yet serum neutralization against live B.1.1.529 (Omicron) is completely abrogated and significantly reduced for other VOCs. Likewise, ancestral SARS-CoV-2-specific memory T cell frequencies are maintained in >50% of convalescents, but the cytokine response in these cells to mutated spike epitopes corresponding to B.1.1.529 and B.1.351 (Beta) VOCs were impaired. These results indicate that increased antigen variability in VOCs impairs humoral and spike-specific T cell immunity post-infection, strongly suggesting that COVID-19 convalescents are vulnerable and at risk of re-infection with VOCs, thus stressing the importance of vaccination programs.
- Published
- 2022
3. Rapid spread of the SARS-CoV-2 JN.1 lineage is associated with increased neutralization evasion
- Author
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Zhang, Lu, Dopfer-Jablonka, Alexandra, Cossmann, Anne, Stankov, Metodi V., Graichen, Luise, Moldenhauer, Anna-Sophie, Fichter, Christina, Aggarwal, Anupriya, Turville, Stuart G., Behrens, Georg M.N., Pöhlmann, Stefan, and Hoffmann, Markus
- Published
- 2024
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4. Early trajectories of virological and immunological biomarkers and clinical outcomes in patients admitted to hospital for COVID-19: an international, prospective cohort study
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Sahner, David, Tierney, John, Vogel, Susan E., Herpin, Betsey R., Smolskis, Mary C., McKay, Laura A., Cahill, Kelly, Crew, Page, Sardana, Ratna, Raim, Sharon Segal, Hensely, Lisa, Lorenzo, Johsua, Mock, Rebecca, Zuckerman, Judith, Atri, Negin, Miller, Mark, Vallee, David, Chung, Lucy, Kang, Nayon, Barrett, Kevin, Adam, Stacey J., Read, Sarah, Draghia-Akli, Ruxandra, Currier, Judy, Hughes, Eric, Harrigan, Rachel H., Amos, Laura, Carlsen, Amy, Carter, Anita, Collins, Gary, Davis, Bionca, Denning, Eileen, DuChene, Alain, Eckroth, Kate, Engen, Nicole, Frase, Alex, Gandits, Greg, Grund, Birgit, Harrison, Merrie, Hurlbut, Nancy, Kaiser, Payton, Koopmeiners, Joseph, Larson, Gregg, Meger, Sue, Mistry, Shweta Sharma, Murray, Thomas, Nelson, Ray, Quan, Kien, Quan, Siu Fun, Reilly, Cavan, Siegel, Lianne, Thompson, Greg, Vock, David, Walski, Jamie, Gelijns, Annetine C., Moskowitz, Alan J., Bagiella, Emilia, Moquete, Ellen, O'Sullivan, Karen, Marks, Mary E., Accardi, Evan, Kinzel, Emily, Burris, Sarah, Bedoya, Gabriela, Gupta, Lola, Overbey, Jessica R., Santos, Milerva, Gillinov, Marc A., Miller, Marissa A., Taddei-Peters, Wendy C., Fenton, Kathleen, Sandkovsky, Uriel, Gottlieb, Robert L., Mack, Michael, Berhe, Mezgebe, Haley, Clinton, Dishner, Emma, Bettacchi, Christopher, Golden, Kevin, Duhaime, Erin, Ryan, Madison, Tallmadge, Catherine, Estrada, Lorie, Jones, Felecia, Villa, Samatha, Wang, Samatha, Robert, Raven, Coleman, Tanquinisha, Clariday, Laura, Baker, Rebecca, Hurutado-Rodriguez, Mariana, Iram, Nazia, Fresnedo, Michelle, Davis, Allyson, Leonard, Kiara, Ramierez, Noelia, Thammavong, Jon, Duque, Krizia, Turner, Emma, Fisher, Tammy, Robinson, Dianna, Ransom, Desirae, Maldonado, Nicholas, Lusk, Erica, Killian, Aaron, Palacious, Adriana, Solis, Edilia, Jerrow, Janet, Watts, Matthew, Whitacre, Heather, Cothran, Elizabeth, Smith, Peter K., Barkauskas, Christina E., Vekstein, Andrew M., Ko, Emily R., Dreyer, Grace R., Stafford, Neil, Brooks, Megan, Der, Tatyana, Witte, Marie, Gamarallage, Ruwan, Franzone, John, Ivey, Noel, Lumsden, Rebecca H., Mosaly, Nilima, Mourad, Ahmaad, Holland, Thomas L., Motta, Mary, Lane, Kathleen, McGowan, Lauren M., Stout, Jennifer, Aloor, Heather, Bragg, Kennesha M., Toledo, Barvina, McLendon-Arvik, Beth, Bussadori, Barbara, Hollister, Beth A., Griffin, Michelle, Giangiacomo, Dana M., Rodriguez, Vicente, Bokhart, Gordon, Eichman, Sharon M., Parrino, Patrick E., Spindel, Stephen, Bansal, Aditya, Baumgarten, Katherine, Hand, Johnathan, Vonderhaar, Derek, Nossaman, Bobby, Sylvia Laudun, Ames, DeAnna, Broussard, Shane, Hernandez, Nilmo, Isaac, Geralyn, Dinh, Huan, Zheng, Yiling, Tran, Sonny, McDaniel, Hunter, Crovetto, Nicolle, Perin, Emerson, Costello, Briana, Manian, Prasad, Sohail, M. Rizwan, Postalian, Alexander, Hinsu, Punit, Watson, Carolyn, Chen, James, Fink, Melyssa, Sturgis, Lydia, Walker, Kim, Mahon, Kim, Parenti, Jennifer, Kappenman, Casey, Knight, Aryn, Sturek, Jeffrey M., Barros, Andrew, Enfield, Kyle B., Kadl, Alexandra, Green, China J., Simon, Rachel M., Fox, Ashley, Thornton, Kara, Adams, Amy, Badhwar, Vinay, Sharma, Sunil, Peppers, Briana, McCarthy, Paul, Krupica, Troy, Sarwari, Arif, Reece, Rebecca, Fornaresico, Lisa, Glaze, Chad, Evans, Raquel, Di, Fang, Carlson, Shawn, Aucremanne, Tanja, Tennant, Connie, Sutton, Lisa Giblin, Buterbaugh, Sabrina, Williams, Roger, Bunner, Robin, Traverse, Jay H., Rhame, Frank, Huelster, Joshua, Kethireddy, Rajesh, Davies, Irena, Salamanca, Julianne, Majeski, Christine, Skelton, Paige, Zarambo, Maria, Sarafolean, Andrea, Bowdish, Michael E., Borok, Zea, Wald-Dickler, Noah, Hutcheon, Douglass, Towfighi, Amytis, Lee, Mary, Lewis, Meghan R., Spellberg, Brad, Sher, Linda, Sharma, Aniket, Olds, Anna P., Justino, Chris, Loxano, Edward, Romero, Chris, Leong, Janet, Rodina, Valentina, Quesada, Christine, Hamilton, Luke, Escobar, Jose, Leshnower, Brad, Bender, William, Sharifpour, Milad, Miller, Jeffrey, Farrington, Woodrow, Baio, Kim T., McBride, Mary, Fielding, Michele, Mathewson, Sonya, Porte, Kristina, Maton, Missy, Ponder, Chari, Haley, Elisabeth, Spainhour, Christine, Rogers, Susan, Tyler, Derrick, Madathil, Ronson J., Rabin, Joseph, Levine, Andrea, Saharia, Kapil, Tabatabai, Ali, Lau, Christine, Gammie, James S., Peguero, Maya-Loren, McKernan, Kimberly, Audette, Mathew, Fleischmann, Emily, Akbari, Kreshta, Lee, Myounghee, Chi, Andrew, Salehi, Hanna, Pariser, Alan, Nyguyen, Phuong Tran, Moore, Jessica, Gee, Adrienne, Vincent, Shelika, Zuckerman, Richard A., Iribarne, Alexander, Metzler, Sara, Shipman, Samantha, Johnson, Haley, Newton, Crystallee, Parr, Doug, Miller, Leslie, Schelle, Beth, McLean, Sherry, Rothbaum, Howard R., Alvarez, Michael S., Kalan, Shivam P., Germann, Heather H., Hendershot, Jennifer, Moroney, Karen, Herring, Karen, Cook, Sharri, Paul, Pam, Walker-Ignasiak, Rebecca, North, Crystal, Oldmixon, Cathryn, Ringwood, Nancy, Muzikansky, Ariela, Morse, Richard, Fitzgerald, Laura, Morin, Haley D., Brower, Roy G., Reineck, Lora A., Bienstock, Karen, Steingrub, Jay H., Hou, Peter K., Steingrub, Jay S., Tidswell, Mark A., Kozikowski, Lori-Ann, Kardos, Cynthia, DeSouza, Leslie, Romain, Sarah, Thornton-Thompson, Sherell, Talmor, Daniel, Shapiro, Nathan, Andromidas, Konstantinos, Banner-Goodspeed, Valerie, Bolstad, Michael, Boyle, Katherine L., Cabrera, Payton, deVilla, Arnaldo, Ellis, Joshua C., Grafals, Ana, Hayes, Sharon, Higgins, Conor, Kurt, Lisa, Kurtzman, Nicholas, Redman, Kimberly, Rosseto, Elinita, Scaffidi, Douglas, Filbin, Michael R., Hibbert, Kathryn A., Parry, Blair, Margolin, Justin, Hillis, Brooklynn, Hamer, Rhonda, Brait, Kelsey, Beakes, Caroline, McKaig, Brenna, Kugener, Eleonore, Jones, Alan E., Galbraith, James, Nandi, Utsav, Peacock, Rebekah, Hendey, Gregory, Kangelaris, Kirsten, Ashktorab, Kimia, Gropper, Rachel, Agrawal, Anika, Yee, Kimberley J., Jauregui, Alejandra E., Zhuo, Hanjing, Almasri, Eyad, Fayed, Mohamed, Hubel, Kinsley A., Hughes, Alyssa R., Garcia, Rebekah L., Lim, George W., Chang, Steven Y., Lin, Michael Y., Vargas, Julia, Sihota, Hena, Beutler, Rebecca, Agarwal, Trisha, Wilson, Jennifer G., Vojnik, Rosemary, Perez, Cynthia, McDowell, Jordan H., Roque, Jonasel, Wang, Henry, Huebinger, Ryan M., Patel, Bela, Vidales, Elizabeth, Albertson, Timothy, Hardy, Erin, Harper, Richart, Moss, Marc A., Baduashvili, Amiran, Chauhan, Lakshmi, Douin, David J., Martinez, Flora, Finck, Lani L., Bastman, Jill, Howell, Michelle, Higgins, Carrie, McKeehan, Jeffrey, Finigan, Jay, Stubenrauch, Peter, Janssen, William J., Griesmer, Christine, VerBurg, Olivia, Hyzy, Robert C., Park, Pauline K., Nelson, Kristine, McSparron, Jake I., Co, Ivan N., Wang, Bonnie R., Jimenez, Jose, Olbrich, Norman, McDonough, Kelli, Jia, Shijing, Hanna, Sinan, Gong, Michelle N., Richardson, Lynne D., Nair, Rahul, Lopez, Brenda, Amosu, Omowunmi, Offor, Obiageli, Tzehaie, Hiwet, Nkemdirim, William, Boujid, Sabah, Mosier, Jarrod M., Hypes, Cameron, Campbell, Elizabeth Salvagio, Bixby, Billie, Gilson, Boris, Lopez, Anitza, Bime, Christian, Parthasarathy, Sairam, Cano, Ariana M., Hite, R. Duncan, Terndrup, Thomas E., Wiedemann, Herbert P., Hudock, Kristin, Tanzeem, Hammad, More, Harshada, Martinkovic, Jamie, Sellers, Susan, Houston, Judy, Burns, Mary, Kiran, Simra, Roads, Tammy, Kennedy, Sarah, Duggal, Abhijit, Thiruchelvam, Nirosshan, Ashok, Kiran, King, Alexander H., Mehkri, Omar, Dugar, Siddharth, Sahoo, Debasis, Yealy, Donald M., Angus, Derek C., Weissman, Alexandra J., Vita, Tina M., Berryman, Emily, Hough, Catherine L., Khan, Akram, Krol, Olivia F., Mills, Emmanuel, Kinjal, Mistry, Briceno, Genesis, Reddy, Raju, Hubel, Kinsley, Jouzestani, Milad K., McDougal, Madeline, Deshmukh, Rupali, Johnston, Nicholas J., Robinson, Bryce H., Gundel, Staphanie J., Katsandres, Sarah C., Chen, Peter, Torbati, Sam S., Parimon, Tanyalak, Caudill, Antonina, Mattison, Brittany, Jackman, Susan E., Chen, Po-En, Bayoumi, Emad, Ojukwu, Cristabelle, Fine, Devin, Weissberg, Gwendolyn, Isip, Katherine, Choi-Kuaea, Yunhee, Mehdikhani, Shaunt, Dar, Tahir B., Fleury Augustin, Nsole Biteghe, Tran, Dana, Dukov, Jennifer Emilow, Matusov, Yuri, Choe, June, Hindoyan, Niree A., Wynter, Timothy, Pascual, Ethan, Clapham, Gregg J., Herrera, Lisa, Caudill, Antonia, O’Mahony, D. Shane, Nyatsatsang, Sonam T., Wilson, David M., Wallick, Julie A., Duven, Alexandria M., Fletcher, Dakota D., Miller, Chadwick, Files, D. Clark, Gibbs, Kevin W., Flores, Lori S., LaRose, Mary E., Landreth, Leigha D., Palacios, D. Rafael, Parks, Lisa, Hicks, Madeline, Goodwin, Andrew J., Kilb, Edward F., Lematty, Caitlan T., Patti, Kerilyn, Grady, Abigail, Rasberry, April, Morris, Peter E., Sturgill, Jamie L., Cassity, Evan P., Dhar, Sanjay, Montgomery-Yates, Ashley A., Pasha, Sarah N., Mayer, Kirby P., Pharm.D., Brittany Bissel, Trott, Terren, Rehman, Shahnaz, de Wit, Marjolein, Mason, Jessica, Bledsoe, Joseph, Knowlton, Kirk U., Brown, Samuel, Lanspa, Michael, Leither, Lindsey, Pelton, Ithan, Armbruster, Brent P., Montgomery, Quinn, Kumar, Naresh, Fergus, Melissa, Imel, Karah, Palmer, Ghazal, Webb, Brandon, Klippel, Carolyn, Jensen, Hannah, Duckworth, Sarah, Gray, Andrew, Burke, Tyler, Knox, Dan, Lumpkin, Jenna, Aston, Valerie T., Applegate, Darrin, Serezlic, Erna, Brown, Katie, Merril, Mardee, Harris, Estelle S., Middleton, Elizabeth A., Barrios, Macy A.G., Greer, Jorden, Schmidt, Amber D., Webb, Melissa K., Paine, Roert, Callahan, Sean J., Waddoups, Lindsey J., Yamane, Misty B., Self, Wesley H., Rice, Todd W., Casey, Jonathan D., Johnson, Jakea, Gray, Christopher, Hays, Margaret, Roth, Megan, Menon, Vidya, Kasubhai, Moiz, Pillai, Anjana, Daniel, Jean, Sittler, Daniel, Kanna, Balavenkatesh, Jilani, Nargis, Amaro, Francisco, Santana, Jessica, Lyakovestsky, Aleksandr, Madhoun, Issa, Desroches, Louis Marie, Amadon, Nicole, Bahr, Alaa, Ezzat, Imaan, Guerrero, Maryanne, Padilla, Joane, Fullmer, Jessie, Singh, Inderpreet, Ali Shah, Syed Hamad, Narang, Rajeev, Mock, Polly, Shadle, Melissa, Hernandez, Brenda, Welch, Kevin, Payne, Andrea, Ertl, Gabriela, Canario, Daniel, Barrientos, Isabel, Goss, Danielle, DeVries, Mattie, Folowosele, Ibidolapo, Garner, Dorothy, Gomez, Mariana, Price, Justin, Bansal, Ekta, Wong, Jim, Faulhaber, Jason, Fazili, Tasaduq, Yeary, Brian, Ndolo, Ruth, Bryant, Christina, Smigeil, Bridgette, Robinson, Philip, Najjar, Rana, Jones, Patrice, Nguyen, Julie, Chin, Christina, Taha, Hassan, Najm, Salah, Smith, Christopher, Moore, Jason, Nassar, Talal, Gallinger, Nick, Christian, Amy, Mauer, D’Amber, Phipps, Ashley, Waters, Michael, Zepeda, Karla, Coslet, Jordan, Landazuri, Rosalynn, Pineda, Jacob, Uribe, Nicole, Garcia, Jose Ruiz, Barbabosa, Cecilia, Sandler, Kaitlyn, Overcash, J. Scott, Marquez, Adrienna, Chu, Hanh, Lee, Kia, Quillin, Kimberly, Garcia, Andrea, Lew, Pauline, Rogers, Ralph, Shehadeh, Fadi, Mylona, Evangelia K., Kaczynski, Matthew, Tran, Quynh-Lam, Benitez, Gregorio, Mishra, Biswajit, Felix, Lewis Oscar, Vafea, Maria Tsikala, Atalla, Eleftheria, Davies, Robin, Hedili, Salma, Monkeberg, Maria Andrea, Tabler, Sandra, Harrington, Britt, Meegada, Sreenath, Koripalli, Venkata Sandeep, Muddana, Prithvi, Jain, Lakshay, Undavalli, Chaitanya, Kavya, Parasa, Ibiwoye, Mofoluwaso, Akilo, Hameed, Lovette, Bryce D., Wylie, Jamie-Crystal, Smith, Diana M., Poon, Kenneth, Eckardt, Paula, Heysu, Rubio-Gomez, Sundararaman, Nithya, Alaby, Doris, Sareli, Candice, Sánchez, Adriana, Popielski, Laura, Kambo, Amy, Viens, Kimberley, Turner, Melissa, Vjecha, Michael J., Weintrob, Amy, Brar, Indira, Markowitz, Norman, Pastor, Erika, Corpuz, Roweena, Alangaden, George, McKinnon, John, Ramesh, Mayur, Herc, Erica, Yared, Nicholas, Lanfranco, Odaliz Abreu, Rivers, Emanuel, Swiderek, Jennifer, Gupta, Ariella Hodari, Pabla, Pardeep, Eliya, Sonia, Jazrawi, Jehan, Delor, Jeremy, Desai, Mona, Cook, Aaron, Jaehne, Anja Kathrina, Gill, Jasreen Kaur, Renaud, Sheri, Sarveswaran, Siva, Gardner, Edward, Scott, James, Bianchini, Monica, Melvin, Casey, Kim, Gina, Wyles, David, Kamis, Kevin, Miller, Rachel, Douglas, Ivor, Haukoos, Jason, Hicks, Carrie, Lazarte, Susana, Marines-Price, Rubria, Osuji, Alice, Agbor Agbor, Barbine Tchamba, Petersen, Tianna, Kamel, Dena, Hansen, Laura, Garcia, Angie, Cha, Christine, Mozaffari, Azadeh, Hernandez, Rosa, Cutrell, James, Kim, Mina, DellaValle, Natalie, Gonzales, Sonia, Somboonwit, Charurut, Oxner, Asa, Guerra, Lucy, Hayes, Michael, Nguyen, Thi, Tran, Thanh, Pinto, Avenette, Hatlen, Timothy, Anderson, Betty, Zepeda-Gutierrez, Ana, Martin, Dannae, Temblador, Cindi, Cuenca, Avon, Tanoviceanu, Roxanne, Prieto, Martha, Guerrero, Mario, Daar, Eric, Correa, Ramiro, Hartnell, Gabe, Wortmann, Glenn, Doshi, Saumil, Moriarty, Theresa, Gonzales, Melissa, Garman, Kristin, Baker, Jason V., Frosch, Anne, Goldsmith, Rachael, Driver, Brian, Frank, Christine, Leviton, Tzivia, Prekker, Matthew, Jibrell, Hodan, Lo, Melanie, Klaphake, Jonathan, Mackedanz, Shari, Ngo, Linh, Garcia-Myers, Kelly, Kunisaki, Ken M., Wendt, Chris, Melzer, Anne, Wetherbee, Erin, Drekonja, Dimitri, Pragman, Alexa, Hamel, Aimee, Thielen, Abbie, Hassler, Miranda, Walquist, Mary, Augenbraun, Michael, George, Jensen, Demeo, Lynette, Mishko, Motria, Thomas, Lorraine, Tatem, Luis, Dehovitz, Jack, Abassi, Mahsa, Leuck, Anne-Marie, Rao, Via, Pullen, Matthew, Luke, Darlette, LaBar, Derek, Christiansen, Theresa, Howard, Diondra, Biswas, Kousick, Harrington, Cristin, Garcia, Amanda, Bremer, Tammy, Burke, Tara, Koker, Brittany, Davis-Karim, Anne, Pittman, David, Vasudeva, Shikha S., Johnstone, Jaylynn R., Agnetti, Kate, Davis, Ruby, Trautner, Barbara, Hines-Munson, Casey, Van, John, Dillon, Laura, Wang, Yiqun, Nagy-Agren, Stephanie, Vasudeva, Shikha, Ochalek, Tracy, Caldwell, Erin, Humerickhouse, Edward, Boone, David, McGraw, William, Looney, David J., Mehta, Sanjay R., Johns, Scott Thompson, St. John, Melissa, Raceles, Jacqueline, Sear, Emily, Funk, Stephen, Cesarini, Rosa, Fang, Michelle, Nicalo, Keith, Drake, Wonder, Jones, Beatrice, Holtman, Teresa, Nguyen, Hien H., Maniar, Archana, Johnson, Eric A., Nguyen, Lam, Tran, Michelle T., Barrett, Thomas W., Johnston, Tera, Huggins, John T., Beiko, Tatsiana Y., Hughes, Heather Y., McManigle, William C., Tanner, Nichole T., Washburn, Ronald G., Ardelt, Magdalena, Tuohy, Patricia A., Mixson, Jennifer L., Hinton, Charles G., Thornley, Nicola, Allen, Heather, Elam, Shannon, Boatman, Barry, Baber, Brittany J., Ryant, Rudell, Roller, Brentin, Nguyen, Chinh, Mikail, Amani Morgan, Research, Marivic Hansen, Lichtenberger, Paola, Baracco, Gio, Ramos, Carol, Bjork, Lauren, Sueiro, Melyssa, Tien, Phyllis, Freasier, Heather, Buck, Theresa, Nekach, Hafida, Holodniy, Mark, Chary, Aarthi, Lu, Kan, Peters, Theresa, Lopez, Jessica, Tan, Susanna Yu, Lee, Robert H., Asghar, Aliya, Karyn Isip, Tasadduq Karim, Le, Katherine, Nguyen, Thao, Wong, Shinn, Raben, Dorthe, Murray, Daniel D., Jensen, Tomas O., Peters, Lars, Aagaard, Bitten, Nielsen, Charlotte B., Krapp, Katharina, Nykjær, Bente Rosdahl, Olsson, Christina, Kanne, Katja Lisa, Grevsen, Anne Louise, Joensen, Zillah Maria, Bruun, Tina, Bojesen, Ane, Woldbye, Frederik, Normand, Nick E., Esman, Frederik V.L., Benfield, Thomas, Clausen, Clara Lundetoft, Hovmand, Nichlas, Israelsen, Simone Bastrup, Iversen, Katrine, Leding, Caecilie, Pedersen, Karen Brorup, Thorlacius-Ussing, Louise, Tinggaard, Michaela, Tingsgard, Sandra, Krohn-Dehli, Louise, Pedersen, Dorthe, Villadsen, Signe, Staehr Jensen, Jens-Ulrik, Overgaard, Rikke, Rastoder, Ema, Heerfordt, Christian, Hedsund, Caroline, Ronn, Christian Phillip, Kamstrup, Peter Thobias, Hogsberg, Dorthe Sandbaek, Bergsoe, Christina, Søborg, Christian, Hissabu, Nuria M.S., Arp, Bodil C., Ostergaard, Lars, Staerke, Nina Breinholt, Yehdego, Yordanos, Sondergaard, Ane, Johansen, Isik S., Pedersen, Andreas Arnholdt, Knudtzen, Fredrikke C., Larsen, Lykke, Hertz, Mathias A., Fabricius, Thilde, Holden, Inge K., Lindvig, Susan O., Helleberg, Marie, Gerstoft, Jan, Kirk, Ole, Jensen, Tomas Ostergaard, Madsen, Birgitte Lindegaard, Pedersen, Thomas Ingemann, Harboe, Zitta Barrella, Roge, Birgit Thorup, Hansen, Thomas Michael, Glesner, Matilde Kanstrup, Lofberg, Sandra Valborg, Nielsen, Ariella Denize, Leicht von Huth, Sebastian, Nielsen, Henrik, Thisted, Rikke Krog, Petersen, Kristine Toft, Juhl, Maria Ruwald, Podlekareva, Daria, Johnsen, Stine, Andreassen, Helle Frost, Pedersen, Lars, Clara Ellinor Lindnér, Cecilia Ebba, Wiese, Lothar, Knudsen, Lene Surland, Skrøder Nytofte, Nikolaj Julian, Havmøller, Signe Ravn, Expósito, Maria, Badillo, José, Martínez, Ana, Abad, Elena, Chamorro, Ana, Figuerola, Ariadna, Mateu, Lourdes, España, Sergio, Lucero, Maria Constanza, Santos, José Ramón, Lladós, Gemma, Lopez, Cristina, Carabias, Lydia, Molina-Morant, Daniel, Loste, Cora, Bracke, Carmen, Siles, Adrian, Fernández-Cruz, Eduardo, Di Natale, Marisa, Padure, Sergiu, Gomez, Jimena, Ausin, Cristina, Cervilla, Eva, Balastegui, Héctor, Sainz, Carmen Rodríguez, Lopez, Paco, Carbone, Javier, Escobar, Mariam, Balerdi, Leire, Legarda, Almudena, Roldan, Montserrat, Letona, Laura, Muñoz, José, Camprubí, Daniel, Arribas, Jose R., Sánchez, Rocio Montejano, Díaz-Pollán, Beatriz, Stewart, Stefan Mark, Garcia, Irene, Borobia, Alberto, Mora-Rillo, Marta, Estrada, Vicente, Cabello, Noemi, Nuñez-Orantos, M.J., Sagastagoitia, I., Homen, J.R., Orviz, E., Montalvá, Adrián Sánchez, Espinosa-Pereiro, Juan, Bosch-Nicolau, Pau, Salvador, Fernando, Burgos, Joaquin, Morales-Rull, Jose Luis, Moreno Pena, Anna Maria, Acosta, Cristina, Solé-Felip, Cristina, Horcajada, Juan P., Sendra, Elena, Castañeda, Silvia, López-Montesinos, Inmaculada, Gómez-Junyent, Joan, Gonzáles, Carlota Gudiol, Cuervo, Guilermo, Pujol, Miquel, Carratalà, Jordi, Videla, Sebastià, Günthard, Huldrych, Braun, Dominique L., West, Emily, M’Rabeth-Bensalah, Khadija, Eichinger, Mareile L., Grüttner-Durmaz, Manuela, Grube, Christina, Zink, Veronika, pharmacist, Goes pharmacist, Josefine, Fätkenheuer, Gerd, Malin, Jakob J., Tsertsvadze, Tengiz, Abutidze, Akaki, Chkhartishvili, Nikoloz, Metchurtchlishvili, Revaz, Endeladze, Marina, Paciorek, Marcin, Bursa, Dominik, Krogulec, Dominika, Pulik, Piotr, Ignatowska, Anna, Horban, Andrzej, Bakowska, Elzbieta, Kowaska, Justyna, Bednarska, Agnieszka, Jurek, Natalia, Skrzat-Klapaczynska, Agata, Bienkowski, Carlo, Hackiewicz, Malgorzata, Makowiecki, Michal, Platowski, Antoni, Fishchuk, Roman, Kobrynska, Olena, Levandovska, Khrystyna, Kirieieva, Ivanna, Kuziuk, Mykhailo, Naucler, Pontus, Perlhamre, Emma, Mazouch, Lotta, Kelleher, Anthony, Polizzotto, Mark, Carey, Catherine, Chang, Christina C., Hough, Sally, Virachit, Sophie, Davidson, Sarah, Bice, Daniel J., Ognenovska, Katherine, Cabrera, Gesalit, Flynn, Ruth, Young, Barnaby E., Chia, Po Ying, Lee, Tau Hong, Lin, Ray J., Lye, David C., Ong, Sean W.X., Puah, Ser Hon, Yeo, Tsin Wen, Diong, Shiau Hui, Ongko, Juwinda, Yeo, He Ping, Eriobu, Nnakelu, Kwaghe, Vivian, Zaiyad, Habib, Idoko, Godwin, Uche, Blessing, Selvamuthu, Poongulali, Kumarasamy, Nagalingeswaran, Beulah, Faith Ester, Govindarajan, Narayan, Mariyappan, Kowsalya, Losso, Marcelo H., Abela, Cecilia, Moretto, Renzo, Belloc, Carlos G., Ludueña, Jael, Amar, Josefina, Toibaro, Javier, Macias, Laura Moreno, Fernandez, Lucia, Frare, Pablo S., Chaio, Sebastian R., Pachioli, Valeria, Timpano, Stella M., Sanchez, Marisa del Lujan, de Paz Sierra, Mariana, Stanek, Vanina, Belloso, Waldo, Cilenti, Flavia L., Valentini, Ricardo N., Stryjewski, Martin E., Locatelli, Nicolas, Soler Riera, Maria C., Salgado, Clara, Baeck, Ines M., Di Castelnuovo, Valentina, Zarza, Stella M., Hudson, Fleur, Parmar, Mahesh K.B., Goodman, Anna L., Dphil, Badrock, Jonathan, Gregory, Adam, Goodall, Katharine, Harris, Nicola, Wyncoll, James, Bhagani, S., Rodger, A., Luntiel, A., Patterson, C., Morales, J., Witele, E., Preston, A.-M., Nandani, A., Price, D.A., Hanrath, Aiden, Nell, Jeremy, Patel, Bijal, Hays, Carole, Jones, Geraldine, Davidson, Jade, Bawa, T., Mathews, M., Mazzella, A., Bisnauthsing, K., Aguilar-Jimenez, L., Borchini, F., Hammett, S., Touloumi, Giota, Pantazis, Nikos, Gioukari, Vicky, Souliou, Tania, Antoniadou, A., Protopapas, K., Kavatha, D., Grigoropoulou, S., Oikonomopoulo, C., Moschopoulos, C., Koulouris, N.G., Tzimopoulos, K., Koromilias, A., Argyraki, K., Lourida, P., Bakakos, P., Kalomenidis, I., Vlachakos, V., Barmparessou, Z., Balis, E., Zakynthinos, S., Sigala, I., Gianniou, N., Dima, E., Magkouta, S., Synolaki, E., Konstanta, S., Vlachou, M., Stathopoulou, P., Panagopoulos, P., Petrakis, V., Papazoglou, D., Tompaidou, E., Isaakidou, E., Poulakou, G., Rapti, V., Leontis, K., Nitsotolis, T., Athanasiou, K., Syrigos, K., Kyriakoulis, K., Trontzas, I., Arfara-Melanini, M., Kolonis, V., Kityo, Cissy, Mugerwa, Henry, Kiweewa, Francis, Kimuli, Ivan, Lukaakome, Joseph, Nsereko, Christoher, Lubega, Gloria, Kibirige, Moses, Nakahima, William, Wangi, Deus, Aguti, Evelyne, Generous, Lilian, Massa, Rosemary, Nalaki, Margaret, Magala, Felix, Nabaggala, Phiona Kaweesi, Kidega, Robert, Faith, Oryem Daizy, Florence, Apio, Emmanuel, Ocung, Beacham, Mugoonyi Paul, Geoffrey, Amone, Nakiboneka, Dridah, Apiyo, Paska, Kirenga, Bruce, Atukunda, Angella, Muttamba, Winters, Remmy, Kyeyume, Segawa, Ivan, Pheona, Nsubuga, Kigere, David, Mbabazi, Queen Lailah, Boersalino, Ledra, Nyakoolo, Grace, Fred, Aniongo, Alupo, Alice, Ebong, Doryn, Monday, Edson, Nalubwama, Ritah Norah, Kainja, Milton, Ambrose, Munu, Kwehayo, Vanon, Nalubega, Mary Grace, Ongoli, Augustine, Obbo, Stephen, Sebudde, Nicholus, Alaba, Jeniffer, Magombe, Geoffrey, Tino, Harriet, Obonya, Emmanuel, Lutaakome, Joseph, Kitonsa, Jonathan, Onyango, Martin, Naboth, Tukamwesiga, Naluyinda, Hadijah, Nanyunja, Regina, Irene, Muttiibwa, Jane, Biira, Wimfred, Kyobejja, Leonard, Ssemazzi, Deus, Tkiinomuhisha, Babra, Namasaba, Taire, Paul, Nabankema, Evelyn, Ogavu, Joseph, Mugerwa, Oscar, Okoth, Ivan, Mwebaze, Raymond, Mugabi, Timothy, Makhoba, Anthony, Arikiriza, Phiona, Theresa, Nabuuma, Nakayima, Hope, Frank, Kisuule, Ramgi, Patrícia, Pereira, Kássia, Osinusi, Anu, Cao, Huyen, Klekotka, Paul, Price, Karen, Nirula, Ajay, Osei, Suzette, Tipple, Craig, Wills, Angela, Peppercorn, Amanda, Watson, Helen, Gupta, Rajesh, Alexander, Elizabeth, Mogalian, Erik, Lin, Leo, Ding, Xiao, Margolis, David, Yan, Li, Girardet, Jean-Luc, Ma, Ji, Hong, Zhi, Zhu, Quing, Seegobin, Seth, Gibbs, Michael, Latchman, Mickel, Hasior, Katarzyna, Bouquet, Jerome, Wei, Jianxin, Streicher, Katie, Schmelzer, Albert, Brooks, Dennis, Butcher, Jonny, Tonev, Dimitar, Arbetter, Douglas, Damstetter, Philippe, Legenne, Philippe, Stumpp, Michael, Goncalves, Susana, Ramanathan, Krishnan, Chandra, Richa, Baseler, Beth, Teitelbaum, Marc, Schechner, Adam, Holley, H. Preston, Jankelevich, Shirley, Becker, Nancy, Dolney, Suzanne, Hissey, Debbie, Simpson, Shelly, Kim, Mi Ha, Beeler, Joy, Harmon, Liam, Asomah, Mabel, Jato, Yvonne, Stottlemyer, April, Tang, Olivia, Vanderpuye, Sharon, Yeon, Lindsey, Buehn, Molly, Eccard-Koons, Vanessa, Frary, Sadie, MacDonald, Leah, Cash, Jennifer, Hoopengardner, Lisa, Linton, Jessica, Schaffhauser, Marylu, Nelson, Michaela, Spinelli-Nadzam, Mary, Proffitt, Calvin, Lee, Christopher, Engel, Theresa, Fontaine, Laura, Osborne, C.K., Hohn, Matt, Galcik, Michael, Thompson, DeeDee, Kopka, Stacey, Shelley, Denise M., Mendez, Gregg, Brown, Shawn, Albert, Sara, Balde, Abby, Baracz, Michelle, Bielica, Mona, Billouin-Frazier, Shere, Choudary, Jay, Dixon, Mary, Eyler, Carolyn, Frye, Leanne, Gertz, Jensen, Giebeig, Lisa, Gulati, Neelam, Hankinson, Liz, Hogarty, Debi, Huber, Lynda, Krauss, Gary, Lake, Eileen, Manandhar, Meryan, Rudzinski, Erin, Sandrus, Jen, Suders, Connie, Natarajan, Ven, Rupert, Adam W., Baseler, Michael, Lynam, Danielle, Imamichi, Tom, Laverdure, Sylvain, McCormack, Ashley, Paudel, Sharada, Cook, Kyndal, Haupt, Kendra, Khan, Ayub, Hazen, Allison, Badralmaa, Yunden, Smith, Kenneth, Patel, Bhakti, Kubernac, Amanda, Kubernac, Robert, Hoover, Marie L., Solomon, Courtney, Rashid, Marium, Murphy, Joseph, Brown, Craig, DuChateau, Nadine, Ellis, Sadie, Flosi, Adam, Fox, Lisa, Johnson, Les, Nelson, Rich, Stojanovic, Jelena, Treagus, Amy, Wenner, Christine, Williams, Richard, Jensen, Tomas O, Murray, Thomas A, Grandits, Greg A, Jain, Mamta K, Shaw-Saliba, Kathryn, Matthay, Michael A, Baker, Jason V, Dewar, Robin L, Goodman, Anna L, Hatlen, Timothy J, Highbarger, Helene C, Lallemand, Perrine, Leshnower, Bradley G, Looney, David, Moschopoulos, Charalampos D, Murray, Daniel D, Mylonakis, Eleftherios, Rehman, M Tauseef, Rupert, Adam, Stevens, Randy, Turville, Stuart, Wick, Katherine, Lundgren, Jens, and Ko, Emily R
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- 2024
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5. Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients
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Rouet, Romain, Henry, Jake Y., Johansen, Matt D., Sobti, Meghna, Balachandran, Harikrishnan, Langley, David B., Walker, Gregory J., Lenthall, Helen, Jackson, Jennifer, Ubiparipovic, Stephanie, Mazigi, Ohan, Schofield, Peter, Burnett, Deborah L., Brown, Simon H. J., Martinello, Marianne, Hudson, Bernard, Gilroy, Nicole, Post, Jeffrey J., Kelleher, Anthony, Jäck, Hans-Martin, Goodnow, Christopher C., Turville, Stuart G., Rawlinson, William D., Bull, Rowena A., Stewart, Alastair G., Hansbro, Philip M., and Christ, Daniel
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- 2023
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6. Humoral and cellular immunity to SARS-CoV-2 Ancestral and Omicron BA.5 variants following vaccination in myelofibrosis patients
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Alcheikh, Ahmad, Perkins, Griffith B., Pucar, Phillippa A., Cecchin, Amelia, Chai, Cheng Sheng, Tunbridge, Matthew, Akerman, Anouschka, Aggarwal, Anupriya, Milogiannakis, Vanessa, Turville, Stuart, Allen, Sharon, Hissaria, Pravin, Banovic, Tatjana, Coates, P. Toby, and Ross, David M.
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- 2023
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7. The HIV-1 proviral landscape reveals Nef contributes to HIV-1 persistence in effector memory CD4+ T-cells
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Duette, Gabriel, Hiener, Bonnie, Morgan, Hannah, Mazur, Fernando G, Mathivanan, Vennila, Horsburgh, Bethany A, Fisher, Katie, Tong, Orion, Lee, Eunok, Ahn, Haelee, Shaik, Ansari, Fromentin, Rémi, Hoh, Rebecca, Bacchus-Souffan, Charline, Nasr, Najla, Cunningham, Anthony, Hunt, Peter W, Chomont, Nicolas, Turville, Stuart G, Deeks, Steven G, Kelleher, Anthony D, Schlub, Timothy E, and Palmer, Sarah
- Subjects
HIV/AIDS ,Infectious Diseases ,Clinical Research ,Aetiology ,2.1 Biological and endogenous factors ,Infection ,CD4-Positive T-Lymphocytes ,DNA ,Viral ,HIV Infections ,HIV-1 ,Humans ,Proviruses ,Viral Load ,nef Gene Products ,Human Immunodeficiency Virus ,AIDS/HIV ,Adaptive immunity ,Infectious disease ,Molecular genetics ,T cells ,Medical and Health Sciences ,Immunology - Abstract
Despite long-term antiretroviral therapy (ART), HIV-1 persists within a reservoir of CD4+ T cells that contribute to viral rebound if treatment is interrupted. Identifying the cellular populations that contribute to the HIV-1 reservoir and understanding the mechanisms of viral persistence are necessary to achieve an effective cure. In this regard, through Full-Length Individual Proviral Sequencing, we observed that the HIV-1 proviral landscape was different and changed with time on ART across naive and memory CD4+ T cell subsets isolated from 24 participants. We found that the proportion of genetically intact HIV-1 proviruses was higher and persisted over time in effector memory CD4+ T cells when compared with naive, central, and transitional memory CD4+ T cells. Interestingly, we found that escape mutations remained stable over time within effector memory T cells during therapy. Finally, we provided evidence that Nef plays a role in the persistence of genetically intact HIV-1. These findings posit effector memory T cells as a key component of the HIV-1 reservoir and suggest Nef as an attractive therapeutic target.
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- 2022
8. Multiple COVID-19 vaccine doses in CLL and MBL improve immune responses with progressive and high seroconversion
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Shen, Yandong, Freeman, Jane A., Holland, Juliette, Naidu, Kartik, Solterbeck, Ann, Van Bilsen, Nenna, Downe, Paul, Kerridge, Ian, Wallman, Lucinda, Akerman, Anouschka, Aggarwal, Anupriya, Milogiannakis, Vanessa, Martins Costa Gomes, Gabriela, Doyle, Chloe M., Sandgren, Kerrie J., Turville, Stuart, Cunningham, Anthony L., and Mulligan, Stephen P.
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- 2022
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9. Mucosal TLR2-activating protein-based vaccination induces potent pulmonary immunity and protection against SARS-CoV-2 in mice
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Ashhurst, Anneliese S., Johansen, Matt D., Maxwell, Joshua W. C., Stockdale, Skye, Ashley, Caroline L., Aggarwal, Anupriya, Siddiquee, Rezwan, Miemczyk, Stefan, Nguyen, Duc H., Mackay, Joel P., Counoupas, Claudio, Byrne, Scott N., Turville, Stuart, Steain, Megan, Triccas, James A., Hansbro, Philip M., Payne, Richard J., and Britton, Warwick J.
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- 2022
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10. Protocol for SARS-CoV-2 post-vaccine surveillance study in Australian adults and children with cancer: an observational study of safety and serological and immunological response to SARS-CoV-2 vaccination (SerOzNET)
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Body, Amy, Ahern, Elizabeth, Lal, Luxi, Gillett, Karen, Abdulla, Hesham, Opat, Stephen, O’Brien, Tracey, Downie, Peter, Turville, Stuart, Munier, C. Mee Ling, Smith, Corey, MacIntyre, C. Raina, and Segelov, Eva
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- 2022
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11. Virtual screening and in vitro validation of natural compound inhibitors against SARS-CoV-2 spike protein
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Power, Helen, Wu, Jiadai, Turville, Stuart, Aggarwal, Anupriya, Valtchev, Peter, Schindeler, Aaron, and Dehghani, Fariba
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- 2022
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12. Boosting immunity: synergistic antiviral effects of luteolin, vitamin C, magnesium and zinc against SARS-CoV-2 3CLpro.
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Ferreira, Juliana C., Fadl, Samar, Cardoso, Thyago H. S., Andrade, Bruno Silva, Melo, Tarcisio S., de Andrade Silva, Edson Mario, Agarwal, Anupriya, Turville, Stuart J., Saksena, Nitin K., and Rabeh, Wael M.
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COVID-19 ,VITAMIN C ,FLAVONOIDS ,LUTEOLIN ,COVID-19 vaccines - Abstract
SARS-CoV-2 was first discovered in 2019 and has disseminated throughout the globe to pandemic levels, imposing significant health and economic burdens. Although vaccines against SARS-CoV-2 have been developed, their long-term efficacy and specificity have not been determined, and antiviral drugs remain necessary. Flavonoids, which are commonly found in plants, fruits, and vegetables and are part of the human diet, have attracted considerable attention as potential therapeutic agents due to their antiviral and antimicrobial activities and effects on other biological activities, such as inflammation. The present study uses a combination of biochemical, cellular, molecular dynamics, and molecular docking experiments to provide compelling evidence that the flavonoid luteolin (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one) has antiviral activity against SARS-CoV-2 3-chymotrypsin-like protease (3CLpro) that is synergistically enhanced by magnesium, zinc, and vitamin C. The IC50 of luteolin against 2 μM 3CLpro is 78 μM and decreases 10-fold to 7.6 μM in the presence of zinc, magnesium, and vitamin C. Thermodynamic stability analyses revealed that luteolin has minimal effects on the structure of 3CLpro, whereas metal ions and vitamin C significantly alter the thermodynamic stability of the protease. Interactome analysis uncovered potential host-virus interactions and functional clusters associated with luteolin activity, supporting the relevance of this flavone for combating SARS-CoV-2 infection. This comprehensive investigation sheds light on luteolin's therapeutic potential and provides insights into its mechanisms of action against SARS-CoV-2. The novel formulation of luteolin, magnesium, zinc, and vitamin C may be an effective avenue for treating COVID-19 patients. [ABSTRACT FROM AUTHOR]
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- 2024
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13. Dietary Inulin to Improve SARS-CoV-2 Vaccine Response in Kidney Transplant Recipients: The RIVASTIM-Inulin Randomised Controlled Trial.
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Singer, Julian, Tunbridge, Matthew J., Shi, Bree, Perkins, Griffith B., Chai, Cheng Sheng, Salehi, Tania, Sim, Beatrice Z., Kireta, Svjetlana, Johnston, Julie K., Akerman, Anouschka, Milogiannakis, Vanessa, Aggarwal, Anupriya, Turville, Stuart, Hissaria, Pravin, Ying, Tracey, Wu, Huiling, Grubor-Bauk, Branka, Coates, P. Toby, and Chadban, Steven J.
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VACCINE effectiveness ,COVID-19 vaccines ,KIDNEY transplantation ,INULIN ,SHORT-chain fatty acids - Abstract
Kidney transplant recipients are at an increased risk of hospitalisation and death from SARS-CoV-2 infection, and standard two-dose vaccination schedules are typically inadequate to generate protective immunity. Gut dysbiosis, which is common among kidney transplant recipients and known to effect systemic immunity, may be a contributing factor to a lack of vaccine immunogenicity in this at-risk cohort. The gut microbiota modulates vaccine responses, with the production of immunomodulatory short-chain fatty acids by bacteria such as Bifidobacterium associated with heightened vaccine responses in both observational and experimental studies. As SCFA-producing populations in the gut microbiota are enhanced by diets rich in non-digestible fibre, dietary supplementation with prebiotic fibre emerges as a potential adjuvant strategy to correct dysbiosis and improve vaccine-induced immunity. In a randomised, double-bind, placebo-controlled trial of 72 kidney transplant recipients, we found dietary supplementation with prebiotic inulin for 4 weeks before and after a third SARS-CoV2 mRNA vaccine to be feasible, tolerable, and safe. Inulin supplementation resulted in an increase in gut Bifidobacterium, as determined by 16S RNA sequencing, but did not increase in vitro neutralisation of live SARS-CoV-2 virus at 4 weeks following a third vaccination. Dietary fibre supplementation is a feasible strategy with the potential to enhance vaccine-induced immunity and warrants further investigation. [ABSTRACT FROM AUTHOR]
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- 2024
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14. A single dose, BCG-adjuvanted COVID-19 vaccine provides sterilising immunity against SARS-CoV-2 infection
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Counoupas, Claudio, Johansen, Matt D., Stella, Alberto O., Nguyen, Duc H., Ferguson, Angela L., Aggarwal, Anupriya, Bhattacharyya, Nayan D., Grey, Alice, Hutchings, Owen, Patel, Karishma, Siddiquee, Rezwan, Stewart, Erica L., Feng, Carl G., Hansbro, Nicole G., Palendira, Umaimainthan, Steain, Megan C., Saunders, Bernadette M., Low, Jason K. K., Mackay, Joel P., Kelleher, Anthony D., Britton, Warwick J., Turville, Stuart G., Hansbro, Philip M., and Triccas, James A.
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- 2021
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15. Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure.
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Faysal, K. M. Rifat, Walsh, James C., Renner, Nadine, Márquez, Chantal L., Shah, Vaibhav B., Tuckwell, Andrew J., Christie, Michelle P., Parker, Michael W., Turville, Stuart G., Towers, Greg J., James, Leo C., Jacques, David A., and Böcking, Till
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- 2024
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16. The HIV-1 proviral landscape reveals that Nef contributes to HIV-1 persistence in effector memory [CD4.sup.+] T cells
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Duette, Gabriel, Hiener, Bonnie, Morgan, Hannah, Mazur, Fernando G., Mathivanan, Vennila, Horsburgh, Bethany A., Fisher, Katie, Tong, Orion, Lee, Eunok, Ahn, Haelee, Shaik, Ansari, Fromentin, Remi, Hoh, Rebecca, Bacchus-Souffan, Charline, Nasr, Najla, Cunningham, Anthony L., Hunt, Peter W., Chomont, Nicolas, Turville, Stuart G., Deeks, Steven G., Kelleher, Anthony D., Schlub, Timothy E., and Palmer, Sarah
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HIV (Viruses) -- Genetic aspects ,Immunologic memory -- Health aspects -- Genetic aspects ,T cells -- Health aspects -- Genetic aspects ,Antiviral agents -- Patient outcomes ,Viral proteins -- Health aspects -- Genetic aspects ,HIV infection -- Development and progression -- Care and treatment -- Genetic aspects ,Health care industry - Abstract
Despite long-term antiretroviral therapy (ART), HIV-1 persists within a reservoir of [CD4.sup.+] T cells that contribute to viral rebound if treatment is interrupted. Identifying the cellular populations that contribute to the HIV-1 reservoir and understanding the mechanisms of viral persistence are necessary to achieve an effective cure. In this regard, through Full-Length Individual Proviral Sequencing, we observed that the HIV-1 proviral landscape was different and changed with time on ART across naive and memory [CD4.sup.+] T cell subsets isolated from 24 participants. We found that the proportion of genetically intact HIV-1 proviruses was higher and persisted over time in effector memory [CD4.sup.+] T cells when compared with naive, central, and transitional memory [CD4.sup.+] T cells. Interestingly, we found that escape mutations remained stable over time within effector memory T cells during therapy. Finally, we provided evidence that Nef plays a role in the persistence of genetically intact HIV-1. These findings posit effector memory T cells as a key component of the HIV-1 reservoir and suggest Nef as an attractive therapeutic target., Introduction Genetic characterization of HIV-1 proviruses isolated from individuals on suppressive antiretroviral therapy (ART) has revealed that 2%-8% of persistent HIV-1 is genetically intact and potentially replication competent (1-6). Replication-competent [...]
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- 2022
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17. Durable reprogramming of neutralizing antibody responses following Omicron breakthrough infection
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Lee, Wen Shi, primary, Tan, Hyon-Xhi, additional, Reynaldi, Arnold, additional, Esterbauer, Robyn, additional, Koutsakos, Marios, additional, Nguyen, Julie, additional, Amarasena, Thakshila, additional, Kent, Helen E., additional, Aggarwal, Anupriya, additional, Turville, Stuart G., additional, Taiaroa, George, additional, Kinsella, Paul, additional, Liew, Kwee Chin, additional, Tran, Thomas, additional, Williamson, Deborah A., additional, Cromer, Deborah, additional, Davenport, Miles P., additional, Kent, Stephen J., additional, Juno, Jennifer A., additional, Khoury, David S., additional, and Wheatley, Adam K., additional
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- 2023
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18. A broad-spectrum macrocyclic peptide inhibitor of the SARS-CoV-2 spike protein
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Thijssen, Vito, primary, Hurdiss, Daniel L., additional, Debski-Antoniak, Oliver J., additional, Spence, Matthew A., additional, Franck, Charlotte, additional, Norman, Alexander, additional, Aggarwal, Anupriya, additional, Mokiem, Nadia J., additional, van Dongen, David A. A., additional, Vermeir, Stein W., additional, Liu, Minglong, additional, Li, Wentao, additional, Chatziandreou, Marianthi, additional, Donselaar, Tim, additional, Du, Wenjuan, additional, Drulyte, Ieva, additional, Bosch, Berend-Jan, additional, Snijder, Joost, additional, Turville, Stuart G., additional, Payne, Richard J., additional, Jackson, Colin J., additional, van Kuppeveld, Frank J. M., additional, and Jongkees, Seino A. K., additional
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- 2023
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19. Enhanced stability of the SARS CoV-2 spike glycoprotein following modification of an alanine cavity in the protein core
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Poumbourios, Pantelis, primary, Langer, Christine, additional, Boo, Irene, additional, Zakir, Tasnim, additional, Center, Rob J., additional, Akerman, Anouschka, additional, Milogiannakis, Vanessa, additional, Aggarwal, Anupriya, additional, Johnstone, Bronte A., additional, Ha, Jungmin, additional, Coulibaly, Fasséli, additional, Turville, Stuart G., additional, and Drummer, Heidi E., additional
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- 2023
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20. SARS-CoV-2 neutralizing antibodies: Longevity, breadth, and evasion by emerging viral variants
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Tea, Fiona, Ospina Stella, Alberto, Aggarwal, Anupriya, Ross Darley, David, Pilli, Deepti, Vitale, Daniele, Merheb, Vera, Lee, Fiona X. Z., Cunningham, Philip, Walker, Gregory J., Fichter, Christina, Brown, David A., Rawlinson, William D., Isaacs, Sonia R., Mathivanan, Vennila, Hoffmann, Markus, Pöhlman, Stefan, Mazigi, Ohan, Christ, Daniel, Dwyer, Dominic E., Rockett, Rebecca J., Sintchenko, Vitali, Hoad, Veronica C., Irving, David O., Dore, Gregory J., Gosbell, Iain B., Kelleher, Anthony D., Matthews, Gail V., Brilot, Fabienne, and Turville, Stuart G.
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Diseases -- Relapse ,Viral antibodies -- Health aspects ,Immune response -- Health aspects ,Antibodies -- Health aspects ,Biological sciences - Abstract
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) antibody neutralization response and its evasion by emerging viral variants and variant of concern (VOC) are unknown, but critical to understand reinfection risk and breakthrough infection following vaccination. Antibody immunoreactivity against SARS-CoV-2 antigens and Spike variants, inhibition of Spike-driven virus-cell fusion, and infectious SARS-CoV-2 neutralization were characterized in 807 serial samples from 233 reverse transcription polymerase chain reaction (RT-PCR)-confirmed Coronavirus Disease 2019 (COVID-19) individuals with detailed demographics and followed up to 7 months. A broad and sustained polyantigenic immunoreactivity against SARS-CoV-2 Spike, Membrane, and Nucleocapsid proteins, along with high viral neutralization, was associated with COVID-19 severity. A subgroup of 'high responders' maintained high neutralizing responses over time, representing ideal convalescent plasma donors. Antibodies generated against SARS-CoV-2 during the first COVID-19 wave had reduced immunoreactivity and neutralization potency to emerging Spike variants and VOC. Accurate monitoring of SARS-CoV-2 antibody responses would be essential for selection of optimal responders and vaccine monitoring and design., Author(s): Fiona Tea 1, Alberto Ospina Stella 2, Anupriya Aggarwal 2, David Ross Darley 3,4, Deepti Pilli 1, Daniele Vitale 5, Vera Merheb 1, Fiona X. Z. Lee 1, Philip [...]
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- 2021
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21. Emergence and antibody evasion of BQ, BA.2.75 and SARS-CoV-2 recombinant sub-lineages in the face of maturing antibody breadth at the population level
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Akerman, Anouschka, primary, Milogiannakis, Vanessa, additional, Jean, Tyra, additional, Esneau, Camille, additional, Silva, Mariana Ruiz, additional, Ison, Timothy, additional, Fichter, Christina, additional, Lopez, Joseph A., additional, Chandra, Deborah, additional, Naing, Zin, additional, Caguicla, Joanna, additional, Li, Daiyang, additional, Walker, Gregory, additional, Amatayakul-Chantler, Supavadee, additional, Roth, Nathan, additional, Manni, Sandro, additional, Hauser, Thomas, additional, Barnes, Thomas, additional, Condylios, Anna, additional, Yeang, Malinna, additional, Wong, Maureen, additional, Foster, Charles S.P., additional, Sato, Kenta, additional, Lee, Sharon, additional, Song, Yang, additional, Mao, Lijun, additional, Sigmund, Allison, additional, Phu, Amy, additional, Vande More, Ann Marie, additional, Hunt, Stephanie, additional, Douglas, Mark, additional, Caterson, Ian, additional, Britton, Warwick, additional, Sandgren, Kerrie, additional, Bull, Rowena, additional, Lloyd, Andrew, additional, Triccas, Jamie, additional, Tangye, Stuart, additional, Bartlett, Nathan W., additional, Darley, David, additional, Matthews, Gail, additional, Stark, Damien J., additional, Petoumenos, Kathy, additional, Rawlinson, William D., additional, Murrell, Ben, additional, Brilot, Fabienne, additional, Cunningham, Anthony L., additional, Kelleher, Anthony D., additional, Aggarwal, Anupriya, additional, and Turville, Stuart G., additional
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- 2023
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22. Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs
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Loo, Lipin, primary, Waller, Matthew A., additional, Moreno, Cesar L., additional, Cole, Alexander J., additional, Stella, Alberto Ospina, additional, Pop, Oltin-Tiberiu, additional, Jochum, Ann-Kristin, additional, Ali, Omar Hasan, additional, Denes, Christopher E., additional, Hamoudi, Zina, additional, Chung, Felicity, additional, Aggarwal, Anupriya, additional, Low, Jason K. K., additional, Patel, Karishma, additional, Siddiquee, Rezwan, additional, Kang, Taeyoung, additional, Mathivanan, Suresh, additional, Mackay, Joel P., additional, Jochum, Wolfram, additional, Flatz, Lukas, additional, Hesselson, Daniel, additional, Turville, Stuart, additional, and Neely, G. Gregory, additional
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- 2023
- Full Text
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23. A broad-spectrum macrocyclic peptide inhibitor of the SARS-CoV-2 spike protein
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Afd Chemical Biology and Drug Discovery, Virologie, Sub Biomol.Mass Spectrometry & Proteom., Infectious Diseases and Immunology - Virology, Thijssen, Vito, Hurdiss, Daniel L, Debski-Antoniak, Oliver J, Spence, Matthew A, Franck, Charlotte, Norman, Alexander, Aggarwal, Anupriya, Mokiem, Nadia J, van Dongen, David A A, Vermeir, Stein W, Liu, Minglong, Li, Wentao, Chatziandreou, Marianthi, Donselaar, Tim, Du, Wenjuan, Drulyte, Ieva, Bosch, Berend-Jan, Snijder, Joost, Turville, Stuart G, Payne, Richard J, Jackson, Colin J, van Kuppeveld, Frank J M, Jongkees, Seino A K, Afd Chemical Biology and Drug Discovery, Virologie, Sub Biomol.Mass Spectrometry & Proteom., Infectious Diseases and Immunology - Virology, Thijssen, Vito, Hurdiss, Daniel L, Debski-Antoniak, Oliver J, Spence, Matthew A, Franck, Charlotte, Norman, Alexander, Aggarwal, Anupriya, Mokiem, Nadia J, van Dongen, David A A, Vermeir, Stein W, Liu, Minglong, Li, Wentao, Chatziandreou, Marianthi, Donselaar, Tim, Du, Wenjuan, Drulyte, Ieva, Bosch, Berend-Jan, Snijder, Joost, Turville, Stuart G, Payne, Richard J, Jackson, Colin J, van Kuppeveld, Frank J M, and Jongkees, Seino A K
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- 2023
24. High titre neutralizing antibodies in response to SARS–CoV–2 infection require RBD–specific CD4 T cells that include proliferative memory cells
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Phetsouphanh, Chansavath, primary, Khoo, Weng Hua, additional, Jackson, Katherine, additional, Klemm, Vera, additional, Howe, Annett, additional, Aggarwal, Anupriya, additional, Akerman, Anouschka, additional, Milogiannakis, Vanessa, additional, Stella, Alberto Ospina, additional, Rouet, Romain, additional, Schofield, Peter, additional, Faulks, Megan L., additional, Law, Hannah, additional, Danwilai, Thidarat, additional, Starr, Mitchell, additional, Munier, C. Mee Ling, additional, Christ, Daniel, additional, Singh, Mandeep, additional, Croucher, Peter I., additional, Brilot-Turville, Fabienne, additional, Turville, Stuart, additional, Phan, Tri Giang, additional, Dore, Gregory J., additional, Darley, David, additional, Cunningham, Philip, additional, Matthews, Gail V., additional, Kelleher, Anthony D., additional, and Zaunders, John J., additional
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- 2022
- Full Text
- View/download PDF
25. SARS-CoV-2 Omicron BA.5: Evolving tropism and evasion of potent humoral responses and resistance to clinical immunotherapeutics relative to viral variants of concern
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Aggarwal, Anupriya, primary, Akerman, Anouschka, additional, Milogiannakis, Vanessa, additional, Silva, Mariana Ruiz, additional, Walker, Gregory, additional, Stella, Alberto Ospina, additional, Kindinger, Andrea, additional, Angelovich, Thomas, additional, Waring, Emily, additional, Amatayakul-Chantler, Supavadee, additional, Roth, Nathan, additional, Manni, Sandro, additional, Hauser, Thomas, additional, Barnes, Thomas, additional, Condylios, Anna, additional, Yeang, Malinna, additional, Wong, Maureen, additional, Jean, Tyra, additional, Foster, Charles S.P., additional, Christ, Daniel, additional, Hoppe, Alexandra Carey, additional, Munier, Mee Ling, additional, Darley, David, additional, Churchill, Melissa, additional, Stark, Damien J., additional, Matthews, Gail, additional, Rawlinson, William D., additional, Kelleher, Anthony D., additional, and Turville, Stuart G., additional
- Published
- 2022
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26. Obituary: Remembering Professor David Cooper
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Turville, Stuart and Kelleher, Anthony
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- 2018
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27. Abstract CT259: Comprehensive humoral and cellular immune assessments to SARS-CoV-2 (wild type, delta and omicron) following two- and three-dose vaccination schedule in a large adult cancer population: SerOzNET study: placeholder abstract
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Segelov, Eva, primary, Body, Amy, additional, Luong, Vi, additional, Lopez, Veronica Aedo, additional, Lal, Luxi, additional, Abdulla, Hesham, additional, Turville, Stuart, additional, Niang, Zin, additional, Opat, Stephen, additional, McCuaig, Robert, additional, Lineburg, Katie, additional, Rao, Sudha, additional, Smith, Corey, additional, MacIntyre, Raina, additional, and Ahern, Elizabeth, additional
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- 2022
- Full Text
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28. Abstract CT567: Comprehensive measures of COVID-19 vaccine efficacy in adolescent cancer patients: Results from SerOzNET
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Segelov, Eva, primary, Body, Amy, additional, Turville, Stuart, additional, Smith, Corey, additional, Lineburg, Katie, additional, Rao, Sudha, additional, McCuaig, Robert, additional, Opat, Stephen, additional, Niang, Zin, additional, Lal, Luxi, additional, Luong, Vi, additional, Abdulla, Hesham, additional, Lopez, Veronica Aedo, additional, Padhye, Bhavna, additional, Bolanos, Noemi Fuentes, additional, Anazodo, Antoinette, additional, MacIntyre, Raina, additional, Downie, Peter, additional, O'Brien, Tracey, additional, and Ahern, Elizabeth, additional
- Published
- 2022
- Full Text
- View/download PDF
29. Patients with treated indolent lymphomas immunized with BNT162b2 have reduced anti‐spike neutralizing IgG to SARS‐CoV ‐2 variants, but preserved antigen‐specific T cell responses
- Author
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Beaton, Brendan, primary, Sasson, Sarah C., additional, Rankin, Katherine, additional, Raedemaeker, Juliette, additional, Wong, Alexander, additional, Hastak, Priyanka, additional, Phetsouphanh, Chansavath, additional, Warden, Andrew, additional, Klemm, Vera, additional, Munier, C. Mee Ling, additional, Hoppe, Alexandra Carey, additional, Tea, Fiona, additional, Pillay, Aleha, additional, Stella, Alberto Ospina, additional, Aggarwal, Anupriya, additional, Lavee, Orly, additional, Caterson, Ian D., additional, Turville, Stuart, additional, Kelleher, Anthony D., additional, Brilot, Fabienne, additional, and Trotman, Judith, additional
- Published
- 2022
- Full Text
- View/download PDF
30. HIV-1 infection of human macrophages directly induces viperin which inhibits viral production
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Nasr, Najla, Maddocks, Susan, Turville, Stuart G., Harman, Andrew N., Woolger, Natalie, Helbig, Karla J., Wilkinson, John, Bye, Chris R., Wright, Thomas K., Rambukwelle, Dharshini, Donaghy, Heather, Beard, Michael R., and Cunningham, Anthony L.
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- 2012
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31. High-Titer Neutralizing Antibodies against the SARS-CoV-2 Delta Variant Induced by Alhydroxyquim-II-Adjuvanted Trimeric Spike Antigens
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Counoupas, Claudio, primary, Pino, Paco, additional, Stella, Alberto O., additional, Ashley, Caroline, additional, Lukeman, Hannah, additional, Bhattacharyya, Nayan D., additional, Tada, Takuya, additional, Anchisi, Stephanie, additional, Metayer, Charles, additional, Martinis, Jacopo, additional, Aggarwal, Anupriya, additional, Dcosta, Belinda M., additional, Britton, Warwick J., additional, Kint, Joeri, additional, Wurm, Maria J., additional, Landau, Nathaniel R., additional, Steain, Megan, additional, Turville, Stuart G., additional, Wurm, Florian M., additional, David, Sunil A., additional, and Triccas, James A., additional
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- 2022
- Full Text
- View/download PDF
32. Host glycocalyx captures HIV proximal to the cell surface via oligomannose-GlcNAc glycan-glycan interactions to support viral entry
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Spillings, Belinda L., primary, Day, Christopher J., additional, Garcia-Minambres, Albert, additional, Aggarwal, Anupriya, additional, Condon, Nicholas D., additional, Haselhorst, Thomas, additional, Purcell, Damian F.J., additional, Turville, Stuart G., additional, Stow, Jennifer L., additional, Jennings, Michael P., additional, and Mak, Johnson, additional
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- 2022
- Full Text
- View/download PDF
33. Maintenance of broad neutralizing antibodies and memory B cells 1 year post-infection is predicted by SARS-CoV-2-specific CD4+ T cell responses
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Balachandran, Harikrishnan, primary, Phetsouphanh, Chansavath, additional, Agapiou, David, additional, Adhikari, Anurag, additional, Rodrigo, Chaturaka, additional, Hammoud, Mohamed, additional, Shrestha, Lok Bahadur, additional, Keoshkerian, Elizabeth, additional, Gupta, Money, additional, Turville, Stuart, additional, Christ, Daniel, additional, King, Cecile, additional, Sasson, Sarah C., additional, Bartlett, Adam, additional, Grubor-Bauk, Branka, additional, Rawlinson, William, additional, Aggarwal, Anupriya, additional, Stella, Alberto Ospina, additional, Klemm, Vera, additional, Mina, Michael M., additional, Post, Jeffrey J., additional, Hudson, Bernard, additional, Gilroy, Nicky, additional, Konecny, Pam, additional, Ahlenstiel, Golo, additional, Dwyer, Dominic E., additional, Sorrell, Tania C., additional, Kelleher, Anthony, additional, Tedla, Nicodemus, additional, Lloyd, Andrew R., additional, Martinello, Marianne, additional, and Bull, Rowena A., additional
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- 2022
- Full Text
- View/download PDF
34. Maintenance of broad neutralizing antibodies and memory B cells 1 year post-infection is predicted by SARS-CoV-2-specific CD4+ T cell responses
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Balachandran, Harikrishnan, Phetsouphanh, Chansavath, Agapiou, David, Adhikari, Anurag, Rodrigo, Chaturaka, Hammoud, Mohamed, Shrestha, Lok Bahadur, Keoshkerian, Elizabeth, Gupta, Money, Turville, Stuart, Christ, Daniel, King, Cecile, Sasson, Sarah C., Bartlett, Adam, Grubor-Bauk, Branka, Rawlinson, William, Aggarwal, Anupriya, Stella, Alberto Ospina, Klemm, Vera, Mina, Michael M., Post, Jeffrey J., Hudson, Bernard, Gilroy, Nicky, Konecny, Pam, Ahlenstiel, Golo, Dwyer, Dominic E., Sorrell, Tania C., Kelleher, Anthony, Tedla, Nicodemus, Lloyd, Andrew R., Martinello, Marianne, Bull, Rowena A., and Group, COSIN Study
- Subjects
Adult ,CD4-Positive T-Lymphocytes ,Male ,Delta variant ,QH301-705.5 ,SARS-CoV-2 OX40 CD4 T cell assay ,Antibodies, Viral ,variants of concern ,Severity of Illness Index ,Article ,General Biochemistry, Genetics and Molecular Biology ,protection efficacy prediction ,Cohort Studies ,Memory B Cells ,Humans ,Biology (General) ,SARS-CoV-2 ,Australia ,Immunity ,RBD-specific memory B cells longevity ,COVID-19 ,SARS-CoV-2 antibody duration ,Antibodies, Neutralizing ,12 months after SARS-CoV-2 infection ,Immunity, Humoral ,Coronavirus ,SARS-CoV-2 neutralization ,Spike Glycoprotein, Coronavirus ,Female ,Broadly Neutralizing Antibodies - Abstract
Understanding the long-term maintenance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity is critical for predicting protection against reinfection. In an age- and gender-matched cohort of 24 participants, the association of disease severity and early immune responses on the maintenance of humoral immunity 12 months post-infection is examined. All severely affected participants maintain a stable subset of SARS-CoV-2 receptor-binding domain (RBD)-specific memory B cells (MBCs) and good neutralizing antibody breadth against the majority of the variants of concern, including the Delta variant. Modeling these immune responses against vaccine efficacy data indicate a 45%–76% protection against symptomatic infection (variant dependent). Overall, these findings indicate durable humoral responses in most participants after infection, reasonable protection against reinfection, and implicate baseline antigen-specific CD4+ T cell responses as a predictor of maintenance of antibody neutralization breadth and RBD-specific MBC levels at 12 months post-infection., Graphical abstract, One year after SARS-CoV-2 infection, despite declining antibody titers, Balachandran et al. report a disease-severity-associated maintenance of antibody functions and memory B cell magnitudes. The convalescent serum could neutralize most VOCs, and the initial CD4 T cell levels predict the antibody neutralization breadth and memory B cell durability.
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- 2022
35. Additional file 3 of Protocol for SARS-CoV-2 post-vaccine surveillance study in Australian adults and children with cancer: an observational study of safety and serological and immunological response to SARS-CoV-2 vaccination (SerOzNET)
- Author
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Body, Amy, Ahern, Elizabeth, Lal, Luxi, Gillett, Karen, Abdulla, Hesham, Opat, Stephen, O���Brien, Tracey, Downie, Peter, Turville, Stuart, Munier, C. Mee Ling, Smith, Corey, MacIntyre, C. Raina, and Segelov, Eva
- Subjects
digestive system diseases - Abstract
Additional file 3: Appendix S3. SerOzNET Patient Reported Outcomes Common Terminology Criteria for Adverse Events: PRO-CTCAE.
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- 2022
- Full Text
- View/download PDF
36. Patients with treated indolent lymphomas immunized with BNT162b2 have reduced anti‐spike neutralizing IgG to SARS‐CoV‐2 variants, but preserved antigen‐specific T cell responses
- Author
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Beaton, Brendan, Sasson, Sarah C., Rankin, Katherine, Raedemaeker, Juliette, Wong, Alexander, Hastak, Priyanka, Phetsouphanh, Chansavath, Warden, Andrew, Klemm, Vera, Munier, C. Mee Ling, Hoppe, Alexandra Carey, Tea, Fiona, Pillay, Aleha, Stella, Alberto Ospina, Aggarwal, Anupriya, Lavee, Orly, Caterson, Ian D., Turville, Stuart, Kelleher, Anthony D., Brilot, Fabienne, and Trotman, Judith
- Subjects
Coronavirus ,COVID-19 - Abstract
Patients with indolent lymphoma undertaking recurrent or continuous B cell suppression are at risk of severe COVID-19. Patients and healthy controls (HC; N=13) received 2 doses of BNT162b2: Follicular Lymphoma (FL; N=35) who were treatment naïve (TN; N=11) or received immunochemotherapy (ICT; N=23) and Waldenström's Macroglobulinemia (WM; N=37) including TN (N=9), ICT (N=14), or treated with Bruton's Tyrosine Kinase inhibitors (BTKi; N=12). Anti-spike IgG was determined by a high-sensitivity flow-cytometric assay, in addition to live-virus neutralization. Antigen-specific T cells were identified by co-expression of CD69/CD137 and CD25/CD134 on T cells. A subgroup (N=29) were assessed for third mRNA vaccine response, including omicron neutralization. One month after second BNT162b2, median anti-spike IgG mean fluorescence intensity (MFI) in FL ICT patients (9977) was 25-fold lower than TN (245898) and HC (228255, p=0.0002 for both). Anti-spike IgG correlated with lymphocyte count (r=0.63; p=0.002), and time from treatment, (r=0.56; p=0.007) on univariate analysis, but only with lymphocyte count on multivariate analysis (p=0.03). In the WM cohort, median anti-spike IgG MFI in BTKi patients (39039) was reduced compared to TN (220645, p=0.0008) and HC (p
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- 2022
37. Additional file 1 of Protocol for SARS-CoV-2 post-vaccine surveillance study in Australian adults and children with cancer: an observational study of safety and serological and immunological response to SARS-CoV-2 vaccination (SerOzNET)
- Author
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Body, Amy, Ahern, Elizabeth, Lal, Luxi, Gillett, Karen, Abdulla, Hesham, Opat, Stephen, O���Brien, Tracey, Downie, Peter, Turville, Stuart, Munier, C. Mee Ling, Smith, Corey, MacIntyre, C. Raina, and Segelov, Eva
- Abstract
Additional file 1: Appendix S1. Common data element collection for SerOzNET.
- Published
- 2022
- Full Text
- View/download PDF
38. Additional file 2 of Protocol for SARS-CoV-2 post-vaccine surveillance study in Australian adults and children with cancer: an observational study of safety and serological and immunological response to SARS-CoV-2 vaccination (SerOzNET)
- Author
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Body, Amy, Ahern, Elizabeth, Lal, Luxi, Gillett, Karen, Abdulla, Hesham, Opat, Stephen, O���Brien, Tracey, Downie, Peter, Turville, Stuart, Munier, C. Mee Ling, Smith, Corey, MacIntyre, C. Raina, and Segelov, Eva
- Abstract
Additional file 2: Appendix S2. Biospecimen handling.
- Published
- 2022
- Full Text
- View/download PDF
39. HIV infection of dendritic cells subverts the IFN induction pathway via IRF-1 and inhibits type 1 IFN production
- Author
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Harman, Andrew N., Lai, Joey, Turville, Stuart, Samarajiwa, Shamith, Gray, Lachlan, Marsden, Valerie, Mercier, Sarah K., Jones, Kate, Nasr, Najla, Rustagi, Arjun, Cumming, Helen, Donaghy, Heather, Mak, Johnson, Gale, Michael, Jr, Churchill, Melissa, Hertzog, Paul, and Cunningham, Anthony L.
- Published
- 2011
- Full Text
- View/download PDF
40. Carrageenan/MIV-150 (PC-815), a Combination Microbicide
- Author
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FERNÁNDEZ-ROMERO, JOSÉ A., THORN, MITCHELL, TURVILLE, STUART G., TITCHEN, KANANI, SUDOL, KRISTIN, LI, JIFAN, MILLER, TODD, ROBBIANI, MELISSA, MAGUIRE, ROBIN A., BUCKHEIT, ROBERT W., HARTMAN, TRACY L., and PHILLIPS, DAVID M.
- Published
- 2007
41. Embedding of HIV Egress within Cortical F-Actin
- Author
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Aggarwal, Anupriya, primary, Stella, Alberto Ospina, additional, Henry, Catherine C., additional, Narayan, Kedar, additional, and Turville, Stuart G., additional
- Published
- 2022
- Full Text
- View/download PDF
42. Antiviral cyclic peptides targeting the main protease of SARS-CoV-2
- Author
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Johansen-Leete, Jason, primary, Ullrich, Sven, additional, Fry, Sarah E., additional, Frkic, Rebecca, additional, Bedding, Max J., additional, Aggarwal, Anupriya, additional, Ashhurst, Anneliese S., additional, Ekanayake, Kasuni B., additional, Mahawaththa, Mithun C., additional, Sasi, Vishnu M., additional, Luedtke, Stephanie, additional, Ford, Daniel J., additional, O'Donoghue, Anthony J., additional, Passioura, Toby, additional, Larance, Mark, additional, Otting, Gottfried, additional, Turville, Stuart, additional, Jackson, Colin J., additional, Nitsche, Christoph, additional, and Payne, Richard J., additional
- Published
- 2022
- Full Text
- View/download PDF
43. Immunizations with diverse sarbecovirus receptor-binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability
- Author
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Burnett, Deborah L., primary, Jackson, Katherine J.L., additional, Langley, David B., additional, Aggarwal, Anupriya, additional, Stella, Alberto Ospina, additional, Johansen, Matt D., additional, Balachandran, Harikrishnan, additional, Lenthall, Helen, additional, Rouet, Romain, additional, Walker, Gregory, additional, Saunders, Bernadette M., additional, Singh, Mandeep, additional, Li, Hui, additional, Henry, Jake Y., additional, Jackson, Jennifer, additional, Stewart, Alastair G., additional, Witthauer, Franka, additional, Spence, Matthew A., additional, Hansbro, Nicole G., additional, Jackson, Colin, additional, Schofield, Peter, additional, Milthorpe, Claire, additional, Martinello, Marianne, additional, Schulz, Sebastian R., additional, Roth, Edith, additional, Kelleher, Anthony, additional, Emery, Sean, additional, Britton, Warwick J., additional, Rawlinson, William D., additional, Karl, Rudolfo, additional, Schäfer, Simon, additional, Winkler, Thomas H., additional, Brink, Robert, additional, Bull, Rowena A., additional, Hansbro, Philip M., additional, Jäck, Hans-Martin, additional, Turville, Stuart, additional, Christ, Daniel, additional, and Goodnow, Christopher C., additional
- Published
- 2021
- Full Text
- View/download PDF
44. Efficacy of Vaccine BNT162b2 (Pfizer-BioNTech) in Individuals with Waldenstrom's Macroglobulinemia and Follicular Lymphoma in Australia
- Author
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Beaton, Brendan, primary, Sasson, Sarah C, additional, Rankin, Katherine, additional, Raedemaeker, Juliette, additional, Wong, Alexander, additional, Hastak, Priyanka, additional, Warden, Andrew, additional, Ospina Stella, Alberto, additional, Aggarwal, Anupriya, additional, Caterson, Ian D, additional, Phetsouphanh, Chansavath, additional, Turville, Stuart, additional, Kelleher, Anthony D, additional, Brilot, Fabienne, additional, and Trotman, Judith, additional
- Published
- 2021
- Full Text
- View/download PDF
45. Patients with treated indolent lymphomas immunized with BNT162b2 have reduced anti‐spike neutralizing IgG to SARS‐CoV‐2 variants, but preserved antigen‐specific T cell responses.
- Author
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Beaton, Brendan, Sasson, Sarah C., Rankin, Katherine, Raedemaeker, Juliette, Wong, Alexander, Hastak, Priyanka, Phetsouphanh, Chansavath, Warden, Andrew, Klemm, Vera, Munier, C. Mee Ling, Hoppe, Alexandra Carey, Tea, Fiona, Pillay, Aleha, Stella, Alberto Ospina, Aggarwal, Anupriya, Lavee, Orly, Caterson, Ian D., Turville, Stuart, Kelleher, Anthony D., and Brilot, Fabienne
- Published
- 2023
- Full Text
- View/download PDF
46. Long-term persistence of RBD+ memory B cells encoding neutralizing antibodies in SARS-CoV-2 infection
- Author
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Abayasingam, Arunasingam, Balachandran, Harikrishnan, Agapiou, David, Hammoud, Mohamed, Rodrigo, Chaturaka, Keoshkerian, Elizabeth, Li, Hui, Brasher, Nicholas A., Christ, Daniel, Rouet, Romain, Burnet, Deborah, Grubor-Bauk, Branka, Rawlinson, William, Turville, Stuart, Aggarwal, Anupriya, Stella, Alberto Ospina, Fichter, Christina, Brilot, Fabienne, Mina, Michael, Post, Jeffrey J., Hudson, Bernard, Gilroy, Nicky, Dwyer, Dominic, Sasson, Sarah C., Tea, Fiona, Pilli, Deepti, Kelleher, Anthony, Tedla, Nicodemus, Lloyd, Andrew R., Martinello, Marianne, and Bull, Rowena A.
- Published
- 2021
- Full Text
- View/download PDF
47. HIV-1–infected dendritic cells show 2 phases of gene expression changes, with lysosomal enzyme activity decreased during the second phase
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Harman, Andrew N., Kraus, Marianne, Bye, Chris R., Byth, Karen, Turville, Stuart G., Tang, Owen, Mercier, Sarah K., Nasr, Najla, Stern, Josh L., Slobedman, Barry, Driessen, Christoph, and Cunningham, Anthony L.
- Published
- 2009
- Full Text
- View/download PDF
48. Modular Lentiviral Vectors for Highly Efficient Transgene Expression in Resting Immune Cells
- Author
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Fichter, Christina, primary, Aggarwal, Anupriya, additional, Wong, Andrew Kam Ho, additional, McAllery, Samantha, additional, Mathivanan, Vennila, additional, Hao, Bailey, additional, MacRae, Hugh, additional, Churchill, Melissa J., additional, Gorry, Paul R., additional, Roche, Michael, additional, Gray, Lachlan R., additional, and Turville, Stuart, additional
- Published
- 2021
- Full Text
- View/download PDF
49. Discovery of Cyclic Peptide Ligands to the SARS-CoV-2 Spike Protein Using mRNA Display
- Author
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Norman, Alexander, primary, Franck, Charlotte, additional, Christie, Mary, additional, Hawkins, Paige M. E., additional, Patel, Karishma, additional, Ashhurst, Anneliese S., additional, Aggarwal, Anupriya, additional, Low, Jason K. K., additional, Siddiquee, Rezwan, additional, Ashley, Caroline L., additional, Steain, Megan, additional, Triccas, James A., additional, Turville, Stuart, additional, Mackay, Joel P., additional, Passioura, Toby, additional, and Payne, Richard J., additional
- Published
- 2021
- Full Text
- View/download PDF
50. Lentiviral System for Gene Delivery into Resting T-cells
- Author
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Turville, Stuart, The Kirby Institute, Medicine & Health, UNSW, Aggarwal, Anupriya, The Kirby Institute, Medicine & Health, UNSW, Mathivanan, Vennila, The Kirby Institute, Medicine & Health, UNSW, Turville, Stuart, The Kirby Institute, Medicine & Health, UNSW, Aggarwal, Anupriya, The Kirby Institute, Medicine & Health, UNSW, and Mathivanan, Vennila, The Kirby Institute, Medicine & Health, UNSW
- Abstract
Current gene delivery systems suffer from poor genetic delivery into resting T-cells and therefore, compensate for this by using multiple viral challenges, by activating and expanding the cells ex vivo. However, cells activated and expanded in this manner have lower engraftment, proliferative potential and potency. In contrast, the use of resting T-cells overcomes many of these short-comings, but comes with restrictions: Firstly, at the plasma membrane, due to the lack of receptor for the commonly used lentiviral envelope pseudotype, VSVg. Secondly, at reverse transcription (RTN), by intracellular restriction factor, SAMHD1.At the membrane restriction, we focused on the abundant expression of CXCR4 on resting T-cells, by testing a panel of lentiviral systems expressing various CXCR4-dependent, CD4-independent HIV envelopes. Results revealed that the above panel fused poorly or not at all within resting T-cells. The lead envelope was initially derived from HIV-2 VCP isolate, which was dependent on HIV-2 Gag to maintain high fusogenicity. Whilst HIV-2 based lentiviral systems are advantageous; they are not as developed as HIV-1 systems. Thus, we re-investigated a HIV-1 system based on a derivate of iR3A isolate that enters resting T-cells primarily through CXCR4, but to do so, it required modifications to its matrix.Fortunately, SIV and HIV-2 have evolved with the accessory gene, vpx, that directly targets SAMHD1 for degradation and can be readily incorporated into lentiviral particles. Yet it is presently unknown if all vpx genes are equal in their ability to antagonise SAMHD1 and/or enhance RTN. Through bioprospecting a genetically diverse panel of vpx, we tested SAMHD1 antagonism across several cell types. Majority of the Vpx proteins could overcome SAMHD1 restriction in dendritic cells and macrophages, but only one lead Vpx could efficiently achieve this in resting T-cells, and this was due to an additional Lysine within its nuclear localisation signal. Results fu
- Published
- 2021
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