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21 results on '"Tsukune, Yutaka"'

4. Incidence and clinical background of hepatitis B virus reactivation in multiple myeloma in novel agents’ era

Author

Tsukune, Yutaka, Sasaki, Makoto, Odajima, Takeshi, Isoda, Atsushi, Matsumoto, Morio, Koike, Michiaki, Tamura, Hideto, Moriya, Keiichi, Ito, Shigeki, Asahi, Maki, Imai, Yoichi, Tanaka, Junji, Handa, Hiroshi, Koiso, Hiromi, Tanosaki, Sakae, Hua, Jian, Hagihara, Masao, Yahata, Yuriko, Suzuki, Satoko, Watanabe, Sumio, Sugimori, Hiroki, and Komatsu, Norio

Published
2016
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5. A pilot study examining the efficacy of hochuekkito for improving quality of life in patients with myeloproliferative neoplasms

Author

Edahiro, Yoko, primary, Koike, Michiaki, additional, Nojiri, Shuko, additional, Harada, Yoshinao, additional, Gotoh, Akihiko, additional, Fujibayashi, Kazutoshi, additional, Nishizaki, Yuji, additional, Yanagisawa, Naotake, additional, Takaku, Tomoiku, additional, Nitta, Hideaki, additional, Tsukune, Yutaka, additional, Misawa, Kyohei, additional, Kobayashi, Hiroyuki, additional, and Komatsu, Norio, additional

Published
2022
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6. Incidence and risk factors of hepatitis B virus reactivation in patients with multiple myeloma in an era with novel agents: a nationwide retrospective study in Japan

Author

Tsukune, Yutaka, Sasaki, Makoto, Odajima, Takeshi, Sunami, Kazutaka, Takei, Tomomi, Moriuchi, Yukiyoshi, Iino, Masaki, Isoda, Atsushi, Nakaya, Aya, Muta, Tsuyoshi, Miyake, Takaaki, Miyazaki, Koji, Shimizu, Takayuki, Nakajima, Kei, Igarashi, Aiko, Nagafuji, Koji, Kurihara, Taro, Aoyama, Tomonori, Sugimori, Hiroki, and Komatsu, Norio

Published
2017
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8. Hodgkin Lymphoma on Hemodialysis Successfully Treated with Extended Courses of Brentuximab Vedotin

Author

Uchimura, Ayana, primary, Yasuda, Hajime, additional, Ando, Jun, additional, Ota, Yasunori, additional, Sasaki, Makoto, additional, Takaku, Tomoiku, additional, Tsukune, Yutaka, additional, Tsutsui, Miyuki, additional, Edahiro, Yoko, additional, Watanabe, Naoki, additional, Ochiai, Tomonori, additional, Komatsu, Norio, additional, and Ando, Miki, additional

Published
2022
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10. Improvement in the Symptoms and VEGF Levels after Resection of an Extrame Dullary Spinal Tumor and Additional Chemotherapy in a Patient with Multiple Myeloma Complicated with POEMS Syndrome

Author

Sano, Mariko, primary, Iseki, Tatou, additional, Sasaki, Makoto, additional, Tsukune, Yutaka, additional, Yasuda, Hajime, additional, Kanazawa, Kazo, additional, Arakawa, Atsushi, additional, Yokoyama, Kazumasa, additional, Komatsu, Norio, additional, Hattori, Nobutaka, additional, and Nishioka, Kenya, additional

Published
2021
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12. SLAMF3-Mediated Signaling via ERK Pathway Activation Promotes Aggressive Phenotypic Behaviors in Multiple Myeloma

Author

Ishibashi, Mariko, primary, Takahashi, Risa, additional, Tsubota, Asako, additional, Sasaki, Makoto, additional, Handa, Hiroshi, additional, Imai, Yoichi, additional, Tanaka, Norina, additional, Tsukune, Yutaka, additional, Tanosaki, Sakae, additional, Ito, Shigeki, additional, Asayama, Toshio, additional, Sunakawa, Mika, additional, Kaito, Yuta, additional, Kuribayashi-Hamada, Yasuko, additional, Onodera, Asaka, additional, Moriya, Keiichi, additional, Komatsu, Norio, additional, Tanaka, Junji, additional, Odajima, Takeshi, additional, Sugimori, Hiroki, additional, Inokuchi, Koiti, additional, and Tamura, Hideto, additional

Published
2020
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14. A New Prognostic Index for Waldenström Macroglobulinemia Based on a Multicenter Retrospective Study of the Japanese Society of Myeloma

Author

Saito, Akio, primary, Isoda, Atsushi, additional, Odajima, Takeshi, additional, Itagaki, Mitsuhiro, additional, Yamamoto, Go, additional, Hagiwara, Shotaro, additional, Ohno, Tatsuharu, additional, Fujimoto, Ayumi, additional, Sekiguchi, Naohiro, additional, Sunami, Kazutaka, additional, Yokohama, Akihiko, additional, Kurokawa, Mineo, additional, Tsukune, Yutaka, additional, Nakazawa, Hideyuki, additional, Takamatsu, Hiroyuki, additional, Yagi, Hideo, additional, Fuchida, Shin-Ichi, additional, Ito, Shigeki, additional, Harazaki, Yoriko, additional, Watanabe, Reiko, additional, Koike, Michiaki, additional, Miyazaki, Kanji, additional, Suzuki, Kazuhito, additional, Tamura, Hideto, additional, Kohara, Takae, additional, Ozaki, Shuji, additional, Nakamura, Nobuhiko, additional, Nakamura, Yuichi, additional, Wakayama, Toshio, additional, Sugimori, Hiroki, additional, and Murakami, Hirokazu, additional

Published
2018
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15. Clinical impact of serum soluble SLAMF7 in multiple myeloma

Author

Ishibashi, Mariko, primary, Soeda, Saori, additional, Sasaki, Makoto, additional, Handa, Hiroshi, additional, Imai, Yoichi, additional, Tanaka, Norina, additional, Tanosaki, Sakae, additional, Ito, Shigeki, additional, Odajima, Takeshi, additional, Sugimori, Hiroki, additional, Asayama, Toshio, additional, Sunakawa, Mika, additional, Kaito, Yuta, additional, Kinoshita, Ryosuke, additional, Kuribayashi, Yasuko, additional, Onodera, Asaka, additional, Moriya, Keiichi, additional, Tanaka, Junji, additional, Tsukune, Yutaka, additional, Komatsu, Norio, additional, Inokuchi, Koiti, additional, and Tamura, Hideto, additional

Published
2018
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16. Incidence and risk factors of hepatitis B virus reactivation in patients with multiple myeloma in an era with novel agents: a nationwide retrospective study in Japan

Author

Tsukune Yutaka, Sasaki Makoto, Odajima Takeshi, Sunami Kazutaka, Takei Tomomi, Moriuchi Yukiyoshi, Iino Masaki, Isoda Atsushi, Nakaya Aya, Muta Tsuyoshi, Miyake Takaaki, Miyazaki Koji, Shimizu Takayuki, Nakajima Kei, Igarashi Aiko, Nagafuji Koji, Kurihara Taro, Aoyama Tomonori, Sugimori Hiroki, Komatsu Norio, Tsukune Yutaka, Sasaki Makoto, Odajima Takeshi, Sunami Kazutaka, Takei Tomomi, Moriuchi Yukiyoshi, Iino Masaki, Isoda Atsushi, Nakaya Aya, Muta Tsuyoshi, Miyake Takaaki, Miyazaki Koji, Shimizu Takayuki, Nakajima Kei, Igarashi Aiko, Nagafuji Koji, Kurihara Taro, Aoyama Tomonori, Sugimori Hiroki, and Komatsu Norio

Published
2017

18. Retrospective Analysis of Prognostic Factors for Waldenström Macroglobulinemia: A Multicenter Cooperative Study in Japan

Author

Saito, Akio, primary, Isoda, Atsushi, additional, Yokohama, Akihiko, additional, Handa, Hiroshi, additional, Tsukamoto, Norifumi, additional, Tsukune, Yutaka, additional, Sasaki, Makoto, additional, Matsumoto, Morio, additional, Sawamura, Morio, additional, Ito, Shigeki, additional, Toyama, Kohtaro, additional, Koike, Michiaki, additional, Murayama, Kayoko, additional, Onodera, Asaka, additional, Moriya, Keiichi, additional, Tamura, Hideto, additional, Nakahashi, Hirotaka, additional, Tanosaki, Sakae, additional, Sakura, Toru, additional, Karasawa, Masamitsu, additional, Iwashina, Masanori, additional, Kojima, Masaru, additional, Nakamura, Naoya, additional, and Murakami, Hirokazu, additional

Published
2015
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21. Immune checkpoint molecule DNAM-1/CD112 axis is a novel target for natural killer-cell therapy in acute myeloid leukemia.

Author

Kaito Y, Sugimoto E, Nakamura F, Tsukune Y, Sasaki M, Yui S, Yamaguchi H, Goyama S, Nannya Y, Mitani K, Tamura H, and Imai Y

Subjects
Humans, Nectins, Killer Cells, Natural, Receptors, Immunologic, Cell- and Tissue-Based Therapy, Antigens, Differentiation, T-Lymphocyte genetics, Antigens, Differentiation, T-Lymphocyte metabolism, Immune Checkpoint Proteins metabolism, Leukemia, Myeloid, Acute genetics, Leukemia, Myeloid, Acute therapy, Leukemia, Myeloid, Acute metabolism
Abstract

Acute myeloid leukemia (AML) is a hematologic malignancy that frequently relapses, even if remission can be achieved with intensive chemotherapy. One known relapse mechanism is the escape of leukemic cells from immune surveillance. Currently, there is no effective immunotherapy for AML because of the lack of specific antigens. Here, we aimed to elucidate the association between CD155 and CD112 in AML cell lines and primary AML samples and determine the therapeutic response. Briefly, we generated NK-92 cell lines (NK-92) with modified DNAX-associated molecule 1 (DNAM-1) and T-cell immunoglobulin and ITIM domain (TIGIT), which are receptors of CD155 and CD112, respectively. Analysis of 200 cases of AML indicated that the survival of patients with high expression of CD112 was shorter than that of patients with low expression. NK-92 DNAM-1 exhibited enhanced cytotoxic activity against AML cell lines and primary cells derived from patients with AML. DNAM-1 induction in NK-92 cells enhanced the expression of cytotoxicity-related genes, thus overcoming the inhibitory activity of TIGIT. Between CD155 and CD112, CD112 is an especially important target for natural killer (NK)-cell therapy of AML. Using a xenograft model, we confirmed the enhanced antitumor effect of NK-92 DNAM-1 compared with that of NK-92 alone. We also discovered that CD112 (Nectin-2), an immune checkpoint molecule belonging to the Nectin/Nectin-like family, functions as a novel target of immunotherapy. In conclusion, modification of the DNAM-1/CD112 axis in NK cells may be an effective novel immunotherapy for AML. Furthermore, our findings suggest that the levels of expression of these molecules are potential prognostic markers in AML.

Published
2024
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