1. Effectiveness of topical application with dexamethasone during sagittal split osteotomy of the mandible in minimising clinical symptoms of postoperative neurosensory disorders.
- Author
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Logvynenko I, Dakhno L, and Bursova V
- Subjects
- Humans, Male, Female, Adult, Treatment Outcome, Mandibular Nerve, Young Adult, Trigeminal Nerve Injuries prevention & control, Trigeminal Nerve Injuries etiology, Trigeminal Nerve Injuries diagnosis, Glucocorticoids administration & dosage, Mandible surgery, Middle Aged, Anti-Inflammatory Agents administration & dosage, Anti-Inflammatory Agents therapeutic use, Dexamethasone administration & dosage, Dexamethasone therapeutic use, Osteotomy, Sagittal Split Ramus methods, Administration, Topical, Postoperative Complications prevention & control, Postoperative Complications diagnosis
- Abstract
Background: The aim of this study was to investigate the effectiveness of topical application with dexamethasone during BSSO due to its anti-inflammatory effect and decreasing of postoperative nerve oedema in minimising clinical symptoms of NSD associated with inferior alveolar nerve (IAN) injury in postoperative period, based on the results of sensory diagnostic tests, such as light touch test and its modifications., Methods: Through randomisation, 2 groups were selected from 22 patients: the experimental- where topical application with solution of dexamethasone phosphate 0.4% (4 mg/1 ml ampules) during sagittal split osteotomy of the mandible was used, and the control- where the classical technique of BSSO was held., Results: Authors performed diagnostics of NSD using Light Touch test on 1st day, 1st week, 1st month, 3rd month and 6th month postoperatively. The experimental group showed improvements in sensory recovery compared to the control group, particularly from 1 week to 3 months post-surgery. By 6 months, both groups achieved similar levels of sensitivity restoration., Conclusions: This confirms the effectiveness of proposed method and opens up further prospects for the updated function of the IAN following the BSSO., Clinical Trial Number: Not applicable., Competing Interests: Declarations. Ethics approval: All procedures performed in the study were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments. A study was approved by the Ethics Committee of Central Laboratory Diagnosis of the Head, Kyiv, approval number 501. The authors informed the participants about the anonymous and voluntary participation, and the participants provided their consent. Consent for publication: Written informed consent was provided by all participants allowing the publication of any identifying images or clinical information related to them in this study. Competing interests: The authors declare no competing interests., (© 2025. The Author(s).)
- Published
- 2025
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