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3. Main nutrient patterns are associated with prospective weight change in adults from 10 European countries

Author

Freisling, Heinz, Pisa, Pedro T, Ferrari, Pietro, Byrnes, Graham, Moskal, Aurelie, Dahm, Christina C, Vergnaud, Anne-Claire, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, Cadeau, Claire, Kühn, Tilman, Neamat-Allah, Jasmine, Buijsse, Brian, Boeing, Heiner, Halkjær, Jytte, Tjonneland, Anne, Hansen, Camilla P, Quirós, J Ramón, Travier, Noémie, Molina-Montes, Esther, Amiano, Pilar, Huerta, José M, Barricarte, Aurelio, Khaw, Kay-Tee, Wareham, Nicholas, Key, Tim J, Romaguera, Dora, Lu, Yunxia, Lassale, Camille M, Naska, Androniki, Orfanos, Philippos, Trichopoulou, Antonia, Masala, Giovanna, Pala, Valeria, Berrino, Franco, Tumino, Rosario, Ricceri, Fulvio, de Magistris, Maria Santucci, Bueno-de-Mesquita, H Bas, Ocké, Marga C, Sonestedt, Emily, Ericson, Ulrika, Johansson, Mattias, Skeie, Guri, Weiderpass, Elisabete, Braaten, Tonje, Peeters, Petra HM, and Slimani, Nadia

Subjects
Public Health, Biomedical and Clinical Sciences, Nutrition and Dietetics, Health Sciences, Clinical Research, Prevention, Nutrition, Metabolic and endocrine, Adult, Aged, Ascorbic Acid, Calcium, Dietary, Diet, Dietary Fiber, Dietary Proteins, Europe, Female, Folic Acid, Follow-Up Studies, Humans, Linear Models, Male, Middle Aged, Nutrition Assessment, Phosphorus, Dietary, Prospective Studies, Riboflavin, Surveys and Questionnaires, Weight Gain, beta Carotene, Dietary patterns, Energy balance, Nutrients, Obesity, Public health, Weight gain, Nutrition & Dietetics, Nutrition and dietetics, Epidemiology
Abstract

PurposeVarious food patterns have been associated with weight change in adults, but it is unknown which combinations of nutrients may account for such observations. We investigated associations between main nutrient patterns and prospective weight change in adults.MethodsThis study includes 235,880 participants, 25-70 years old, recruited between 1992 and 2000 in 10 European countries. Intakes of 23 nutrients were estimated from country-specific validated dietary questionnaires using the harmonized EPIC Nutrient DataBase. Four nutrient patterns, explaining 67 % of the total variance of nutrient intakes, were previously identified from principal component analysis. Body weight was measured at recruitment and self-reported 5 years later. The relationship between nutrient patterns and annual weight change was examined separately for men and women using linear mixed models with random effect according to center controlling for confounders.ResultsMean weight gain was 460 g/year (SD 950) and 420 g/year (SD 940) for men and women, respectively. The annual differences in weight gain per one SD increase in the pattern scores were as follows: principal component (PC) 1, characterized by nutrients from plant food sources, was inversely associated with weight gain in men (-22 g/year; 95 % CI -33 to -10) and women (-18 g/year; 95 % CI -26 to -11). In contrast, PC4, characterized by protein, vitamin B2, phosphorus, and calcium, was associated with a weight gain of +41 g/year (95 % CI +2 to +80) and +88 g/year (95 % CI +36 to +140) in men and women, respectively. Associations with PC2, a pattern driven by many micro-nutrients, and with PC3, a pattern driven by vitamin D, were less consistent and/or non-significant.ConclusionsWe identified two main nutrient patterns that are associated with moderate but significant long-term differences in weight gain in adults.

Published
2016

5. Plasma carotenoids, vitamin C, tocopherols, and retinol and the risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition cohort

Author

Bakker, Marije F, Peeters, Petra HM, Klaasen, Veronique M, Bueno-de-Mesquita, H Bas, Jansen, Eugene HJM, Ros, Martine M, Travier, Noémie, Olsen, Anja, Tjønneland, Anne, Overvad, Kim, Rinaldi, Sabina, Romieu, Isabelle, Brennan, Paul, Boutron-Ruault, Marie-Christine, Perquier, Florence, Cadeau, Claire, Boeing, Heiner, Aleksandrova, Krasimira, Kaaks, Rudolf, Kühn, Tilman, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Vineis, Paolo, Krogh, Vittorio, Panico, Salvatore, Masala, Giovanna, Tumino, Rosario, Weiderpass, Elisabete, Skeie, Guri, Lund, Eiliv, Quirós, J Ramón, Ardanaz, Eva, Navarro, Carmen, Amiano, Pilar, Sánchez, María-José, Buckland, Genevieve, Ericson, Ulrika, Sonestedt, Emily, Johansson, Matthias, Sund, Malin, Travis, Ruth C, Key, Timothy J, Khaw, Kay-Tee, Wareham, Nick, Riboli, Elio, and van Gils, Carla H

Published
2016
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6. Vegetable and fruit consumption and the risk of hormone receptor–defined breast cancer in the EPIC cohort

Author

Emaus, Marleen J, Peeters, Petra HM, Bakker, Marije F, Overvad, Kim, Tjønneland, Anne, Olsen, Anja, Romieu, Isabelle, Ferrari, Pietro, Dossus, Laure, Boutron-Ruault, Marie Christine, Baglietto, Laura, Fortner, Renée T, Kaaks, Rudolf, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Masala, Giovanna, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Polidoro, Silvia, Skeie, Guri, Lund, Eiliv, Weiderpass, Elisabete, Quirós, J Ramón, Travier, Noémie, Sánchez, María-José, Chirlaque, Maria-Dolores, Ardanaz, Eva, Dorronsoro, Miren, Winkvist, Anna, Wennberg, Maria, Bueno-de-Mesquita, H Bas, Khaw, Kay-Tee, Travis, Ruth C, Key, Timothy J, Aune, Dagfinn, Gunter, Marc, Riboli, Elio, and van Gils, Carla H

Published
2016
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7. Olive oil intake and mortality within the Spanish population (EPIC-Spain)

Author

Buckland, Genevieve, Mayén, Ana Lucia, Agudo, Antonio, Travier, Noemie, Navarro, Carmen, Huerta, José María, Chirlaque, María Dolores, Barricarte, Aurelio, Ardanaz, Eva, Moreno-Iribas, Conchi, Marin, Pilar, Quirós, J Ramón, Redondo, María-Luisa, Amiano, Pilar, Dorronsoro, Miren, Arriola, Larraitz, Molina, Esther, Sanchez, María-José, and Gonzalez, Carlos A

Published
2012
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8. Alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author

Duell, Eric J, Travier, Noémie, Lujan-Barroso, Leila, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Morois, Sophie, Palli, Domenico, Krogh, Vittorio, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Quirós, J Ramón, Sánchez-Cantalejo, Emilio, Navarro, Carmen, Gurrea, Aurelio Barricarte, Dorronsoro, Miren, Khaw, Kay-Tee, Allen, Naomi E, Key, Timothy J, Bueno-de-Mesquita, H Bas, Ros, Martine M, Numans, Mattijs E, Peeters, Petra HM, Trichopoulou, Antonia, Naska, Androniki, Dilis, Vardis, Teucher, Birgit, Kaaks, Rudolf, Boeing, Heiner, Schütze, Madlen, Regner, Sara, Lindkvist, Björn, Johansson, Ingegerd, Hallmans, Göran, Overvad, Kim, Egeberg, Rikke, Tjønneland, Anne, Lund, Eiliv, Weiderpass, Elisabete, Braaten, Tonje, Romieu, Isabelle, Ferrari, Pietro, Jenab, Mazda, Stenling, Roger, Aune, Dagfinn, Norat, Teresa, Riboli, Elio, and González, Carlos A

Published
2011
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9. Physical activity and gain in abdominal adiposity and body weight: prospective cohort study in 288,498 men and women

Author

Ekelund, Ulf, Besson, Herve, Luan, Jian’an, May, Anne M, Sharp, Stephen J, Brage, Søren, Travier, Noemie, Agudo, Antonio, Slimani, Nadia, Rinaldi, Sabina, Jenab, Mazda, Norat, Teresa, Mouw, Traci, Rohrmann, Sabine, Kaaks, Rudolf, Bergmann, Manuela M, Boeing, Heiner, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Overvad, Kim, Jakobsen, Marianne Uhre, Johnsen, Nina Føns, Halkjaer, Jytte, Gonzalez, Carlos A, Rodriguez, Laudina, Sanchez, Maria José, Arriola, Larraitz, Barricarte, Aurelio, Navarro, Carmen, Key, Timothy J, Spencer, Elisabeth A, Orfanos, Philippos, Naska, Androniki, Trichopoulou, Antonia, Manjer, Jonas, Lund, Eiliv, Palli, Dominico, Pala, Valeria, Vineis, Paolo, Mattiello, Amalia, Tumino, Rosario, Bueno-de-Mesquita, H Bas, van den Berg, Saskia W, Odysseos, Andreani D, Riboli, Elio, Wareham, Nicolas J, and Peeters, Petra H

Published
2011
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11. Effects of an Exercise Program in Colon Cancer Patients undergoing Chemotherapy

Author

VAN VULPEN, JONNA K., VELTHUIS, MIRANDA J., STEINS BISSCHOP, CHARLOTTE N., TRAVIER, NOÉMIE, VAN DEN BUIJS, BRAM J. W., BACKX, FRANK J. G., LOS, MAARTJE, ERDKAMP, FRANS L. G., BLOEMENDAL, HAIKO J., KOOPMAN, MIRIAM, DE ROOS, MARNIX A. J., VERHAAR, MARLIES J., TEN BOKKEL-HUININK, DAAN, VAN DER WALL, ELSKEN, PEETERS, PETRA H. M., and MAY, ANNE M.

Published
2016
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12. Mediterranean dietary patterns and prospective weight change in participants of the EPIC-PANACEA project

Author

Romaguera, Dora, Norat, Teresa, Vergnaud, Anne-Claire, Mouw, Traci, May, Anne M, Agudo, Antonio, Buckland, Genevieve, Slimani, Nadia, Rinaldi, Sabina, Couto, Elisabeth, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Cottet, Vanessa, Rohrmann, Sabine, Teucher, Birgit, Bergmann, Manuela, Boeing, Heiner, Tjønneland, Anne, Halkjaer, Jytte, Jakobsen, Marianne Uhre, Dahm, Christina C, Travier, Noemie, Rodriguez, Laudina, Sanchez, Maria José, Amiano, Pilar, Barricarte, Aurelio, Huerta, José María, Luan, Jian’an, Wareham, Nick, Key, Timothy J, Spencer, Elisabeth A, Orfanos, Philippos, Naska, Androniki, Trichopoulou, Antonia, Palli, Domenico, Agnoli, Claudia, Mattiello, Amalia, Tumino, Rosario, Vineis, Paolo, Bueno-de-Mesquita, H Bas, Büchner, Frederike L, Manjer, Jonas, Wirfält, Elisabet, Johansson, Ingegerd, Hellstrom, Veronica, Lund, Eiliv, Braaten, Toni, Engeset, Dagrun, Odysseos, Andreani, Riboli, Elio, and Peeters, Petra HM

Published
2010
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13. Meat consumption and prospective weight change in participants of the EPIC-PANACEA study

Author

Vergnaud, Anne-Claire, Norat, Teresa, Romaguera, Dora, Mouw, Traci, May, Anne M, Travier, Noemie, Luan, Jian’an, Wareham, Nick, Slimani, Nadia, Rinaldi, Sabina, Couto, Elisabeth, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Cottet, Vanessa, Palli, Domenico, Agnoli, Claudia, Panico, Salvatore, Tumino, Rosario, Vineis, Paolo, Agudo, Antonio, Rodriguez, Laudina, Sanchez, Maria Jose, Amiano, Pilar, Barricarte, Aurelio, Huerta, Jose Maria, Key, Timothy J, Spencer, Elisabeth A, Bueno-de-Mesquita, Bas, Büchner, Frederike L, Orfanos, Philippos, Naska, Androniki, Trichopoulou, Antonia, Rohrmann, Sabine, Hermann, Silke, Boeing, Heiner, Buijsse, Brian, Johansson, Ingegerd, Hellstrom, Veronica, Manjer, Jonas, Wirfält, Elisabet, Jakobsen, Marianne Uhre, Overvad, Kim, Tjonneland, Anne, Halkjaer, Jytte, Lund, Eiliv, Braaten, Tonje, Engeset, Dagrun, Odysseos, Andreani, Riboli, Elio, and Peeters, Petra HM

Published
2010
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15. Adherence to the Mediterranean Diet Is Associated with Lower Abdominal Adiposity in European Men and Women1–

Author

Romaguera, Dora, Norat, Teresa, Mouw, Traci, May, Anne M., Bamia, Christina, Slimani, Nadia, Travier, Noemie, Besson, Herve, Luan, Jian’an, Wareham, Nick, Rinaldi, Sabina, Couto, Elisabeth, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Cottet, Vanessa, Palli, Domenico, Agnoli, Claudia, Panico, Salvatore, Tumino, Rosario, Vineis, Paolo, Agudo, Antonio, Rodriguez, Laudina, Sanchez, Maria Jose, Amiano, Pilar, Barricarte, Aurelio, Huerta, Jose Maria, Key, Timothy J., Spencer, Elisabeth A., Bueno-de-Mesquita, H. Bas, Büchner, Frederike L., Orfanos, Philippos, Naska, Androniki, Trichopoulou, Antonia, Rohrmann, Sabine, Kaaks, Rudolf, Bergmann, Manuela, Boeing, Heiner, Johansson, Ingegerd, Hellstrom, Veronica, Manjer, Jonas, Wirfält, Elisabet, Uhre Jacobsen, Marianne, Overvad, Kim, Tjonneland, Anne, Halkjaer, Jytte, Lund, Eiliv, Braaten, Toni, Engeset, Dragun, Odysseos, Andreani, Riboli, Elio, and Peeters, Petra H.M.

Published
2009
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16. Hormonal, Metabolic, and Inflammatory Profiles and Endometrial Cancer Risk Within the EPIC Cohort—A Factor Analysis

Author

Dossus, Laure, Lukanova, Annekatrin, Rinaldi, Sabina, Allen, Naomi, Cust, Anne E., Becker, Susen, Tjonneland, Anne, Hansen, Louise, Overvad, Kim, Chabbert-Buffet, Nathalie, Mesrine, Sylvie, Clavel-Chapelon, Francoise, Teucher, Birgit, Chang-Claude, Jenny, Boeing, Heiner, Drogan, Dagmar, Trichopoulou, Antonia, Benetou, Vasiliki, Bamia, Christina, Palli, Domenico, Agnoli, Claudia, Galasso, Rocco, Tumino, Rosario, Sacerdote, Carlotta, Bueno-de-Mesquita, H. Bas, van Duijnhoven, Fränzel J. B., Peeters, Petra H. M., Onland-Moret, N. Charlotte, Redondo, Maria-Luisa, Travier, Noémie, Sanchez, Maria-Jose, Altzibar, Jone M., Chirlaque, Maria-Dolores, Barricarte, Aurelio, Lundin, Eva, Khaw, Kay-Tee, Wareham, Nicholas, Fedirko, Veronika, Romieu, Isabelle, Romaguera, Dora, Norat, Teresa, Riboli, Elio, and Kaaks, Rudolf

Published
2013
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17. Genetic variation in alcohol dehydrogenase (ADH1A, ADH1B, ADH1C, ADH7) and aldehyde dehydrogenase (ALDH2), alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author

Duell, Eric J., Sala, Núria, Travier, Noémie, Muñoz, Xavier, Boutron-Ruault, Marie Christine, Clavel-Chapelon, Françoise, Barricarte, Aurelio, Arriola, Larraitz, Navarro, Carmen, Sánchez-Cantalejo, Emilio, Quirós, J.Ramón, Krogh, Vittorio, Vineis, Paolo, Mattiello, Amalia, Tumino, Rosario, Khaw, Kay-Tee, Wareham, Nicholas, Allen, Naomi E., Peeters, Petra H., Numans, Mattijs E., Bueno-de-Mesquita, H.B., van Oijen, M.G.H., Bamia, Christina, Benetou, Vassiliki, Trichopoulos, Dimitrios, Canzian, Federico, Kaaks, Rudolf, Boeing, Heiner, Bergmann, Manuela M., Lund, Eiliv, Ehrnström, Roy, Johansen, Dorthe, Hallmans, Göran, Stenling, Roger, Tjønneland, Anne, Overvad, Kim, Ostergaard, Jane Nautrup, Ferrari, Pietro, Fedirko, Veronika, Jenab, Mazda, Nesi, Gabriella, Riboli, Elio, and González, Carlos A.

Published
2012
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18. Plasma Phospholipid Long-Chain n-3 Polyunsaturated Fatty Acids and Body Weight Change

Author

Jakobsen, Marianne U., Dethlefsen, Claus, Due, Karen M., Slimani, Nadia, Chajès, Veronique, May, Anne M., Sørensen, Thorkild I.A., Halkjær, Jytte, Tjønneland, Anne, Clavel-Chapelon, Francoise, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, Teucher, Birgit, Kaaks, Rudolf, Boeing, Heiner, Schütze, Madlen, Trichopoulou, Antonia, Zylis, Dimosthenis, Makrygiannis, George, Palli, Domenico, Mattiello, Amalia, Tagliabue, Giovanna, van der A, Daphne L., Bueno-de-Mesquita, H. B., Rodríguez, Laudina, Travier, Noémie, Molina-Montes, Esther, Huerta, José M., Barricarte, Aurelio, Amiano, Pilar, Manjer, Jonas, Wirfält, Elisabet, Johansson, Ingegerd, Hallmans, Göran, Khaw, Kay-Tee, Wareham, Nicholas J., Crowe, Francesca, Romieu, Isabelle, Riboli, Elio, Peeters, Petra H.M., and Overvad, Kim

Published
2011
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19. Physiological responses in males with and without spinal cord injury to recumbent synchronous versus seated asynchronous arm crank stress tests (Respuestas fisiológicas en hombres con y sin lesión medular al realizar pruebas de esfuerzo con ergómetros de

Author

Oviedo, Guillermo R., primary, Alamo, Juan Mariano, primary, Niño-Mendez, Oscar A., primary, Travier, Noémie, primary, Ventura, Jose L., primary, Soto-Montañez, Carlos A., primary, Vidal, Joan, primary, Medina, Josep, primary, and Javierre, Casimiro, primary

Published
2020
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20. Menstrual and Reproductive Factors, Exogenous Hormone Use, and Gastric Cancer Risk in a Cohort of Women From the European Prospective Investigation Into Cancer and Nutrition

Author

Duell, Eric J., Travier, Noémie, Lujan-Barroso, Leila, Boutron-Ruault, M. C., Clavel-Chapelon, F., Palli, Domenico, Krogh, Vittorio, Mattiello, Amalia, Tumino, Rosario, Sacerdote, Carlotta, Rodriguez, Laudina, Sanchez-Cantalejo, Emilio, Navarro, Carmen, Barricarte, Aurelio, Dorronsoro, Miren, Khaw, Kay-Tee, Wareham, Nicholas, Allen, Naomi E., Tsilidis, Konstantinos K., Bueno-de-Mesquita, H. Bas, Jeurnink, Suzanne M., Numans, M. E., Peeters, Petra H. M., Lagiou, Pagona, Valanou, Elisabeth, Trichopoulou, Antonia, Kaaks, Rudolf, Lukanova-McGregor, Annekatrin, Bergman, Manuela M., Boeing, Heiner, Manjer, Jonas, Lindkvist, Björn, Stenling, Roger, Hallmans, Göran, Dahm, Christina C., Overvad, Kim, Olsen, Anja, Tjonneland, Anne, Bakken, Kjersti, Lund, Eiliv, Jenab, Mazda, McCormack, Valerie, Rinaldi, Sabina, Michaud, Dominique, Mouw, Traci, Nesi, Gabriella, Carneiro, Fatima, Riboli, Elio, and González, Carlos A.

Published
2010
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22. Risk of type 2 diabetes according to traditional and emerging anthropometric indices in Spain, a Mediterranean country with high prevalence of obesity: results from a large-scale prospective cohort study

Author

Huerta José María, Tormo María-José, Chirlaque María-Dolores, Gavrila Diana, Amiano Pilar, Arriola Larraitz, Ardanaz Eva, Rodríguez Laudina, Sánchez María-José, Mendez Michelle, Salmerón Diego, Barricarte Aurelio, Burgui Rosana, Dorronsoro Miren, Larrañaga Nerea, Molina-Montes Esther, Moreno-Iribas Conchi, Quirós José Ramón, Toledo Estefanía, Travier Noémie, González Carlos A, and Navarro Carmen

Subjects
Diabetes, Anthropometry, Obesity, Abdominal obesity, Body mass index, EPIC, Spain, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Abstract Background Obesity is a major risk factor for type 2 diabetes mellitus (T2DM). A proper anthropometric characterisation of T2DM risk is essential for disease prevention and clinical risk assessement. Methods Longitudinal study in 37 733 participants (63% women) of the Spanish EPIC (European Prospective Investigation into Cancer and Nutrition) cohort without prevalent diabetes. Detailed questionnaire information was collected at baseline and anthropometric data gathered following standard procedures. A total of 2513 verified incident T2DM cases occurred after 12.1 years of mean follow-up. Multivariable Cox regression was used to calculate hazard ratios of T2DM by levels of anthropometric variables. Results Overall and central obesity were independently associated with T2DM risk. BMI showed the strongest association with T2DM in men whereas waist-related indices were stronger independent predictors in women. Waist-to-height ratio revealed the largest area under the ROC curve in men and women, with optimal cut-offs at 0.60 and 0.58, respectively. The most discriminative waist circumference (WC) cut-off values were 99.4 cm in men and 90.4 cm in women. Absolute risk of T2DM was higher in men than women for any combination of age, BMI and WC categories, and remained low in normal-waist women. The population risk of T2DM attributable to obesity was 17% in men and 31% in women. Conclusions Diabetes risk was associated with higher overall and central obesity indices even at normal BMI and WC values. The measurement of waist circumference in the clinical setting is strongly recommended for the evaluation of future T2DM risk in women.

Published
2013
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23. Feasibility and Effects of Structured Physical Exercise Interventions in Adults with Relapsing-Remitting Multiple Sclerosis: A Pilot Study

Author

Guillamó Casanoves, Elisabet, Cobo Calvo, Álvaro, Oviedo, Guillermo R., Travier, Noémie, Álamo, Juan, and Universitat Ramon Llull. Facultat de Psicologia, Ciències de l’Educació i de l’Esport Blanquerna

Subjects
Exercici físic, Esclerosi múltiple, Discapacitat física
Abstract

Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsingremitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale

Published
2018

24. Physiological responses in males with and without spinal cord injury to recumbent synchronous versus seated asynchronous arm crank stress tests.

Author

Oviedo, Guillermo R., Alamo, Juan Mariano, Niño-Mendez, Oscar A., Travier, Noémie, Ventura, Jose L., Soto-Montañez, Carlos A., Vidal, Joan, Medina, Josep, and Javierre, Casimiro

Subjects
ARM exercises, SPINAL cord injuries, AEROBIC capacity, EXERCISE, EXERCISE tests, ABSOLUTE value
Abstract

Copyright of Retos: Nuevas Perspectivas de Educación Física, Deporte y Recreación is the property of Federacion Espanola de Asociaciones de Docentes de Educacion Fisica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2021

25. Correction: The Influence of Hormonal Factors on the Risk of Developing Cervical Cancer and Pre-Cancer: Results from the EPIC Cohort

Author

Roura, Esther, Travier, Noémie, Waterboer, Tim, De Sanjosé, Silvia, Bosch, F. Xavier, Pawlita, Michael, Pala, Valeria, Weiderpass, Elisabete, Margall, Núria, Dillner, Joakim, Tjønneland, Anne, Munk, Christian, Khaw, Kay Tee, Overvad, Kim, Clavel-Chapelon, Françoise, Mesrine, Sylvie, Fournier, Agnès, Fortner, Renée T., Ose, Jennifer, Steffen, Annika, Trichopoulou, Antonia, Lagiou, Pagona, Orfanos, Philippos, Masala, Giovanna, Tumino, Rosario, Sacerdote, Carlotta, Polidoro, Silvia, Mattiello, Amalia, Lund, Eiliv, Peeters, Petra H., Bueno-De-Mesquita, H. B., Ramón Quirós, J., Sánchez, María José, Navarro, Carmen, Barricarte, Aurelio, Larrañaga, Nerea, Ekström, Johanna, Lindquist, David, Idahl, Annika, Travis, Ruth C., Merritt, Melissa A., Gunter, Marc J., Rinaldi, Sabina, Tommasino, Massimo, Franceschi, Silvia, Riboli, Elio, and Castellsagué, Xavier

Subjects
Medicine(all), Published Erratum, Agricultural and Biological Sciences(all), Biochemistry, Genetics and Molecular Biology(all)
Published
2016

27. Physical activity and risk of Amyotrophic Lateral Sclerosis in a prospective cohort study

Author

Gallo, Valentina, Vanacore, Nicola, Bueno-de-Mesquita, H Bas, Vermeulen, Roel, Brayne, Carol, Pearce, Neil, Wark, Petra A, Ward, Heather A, Ferrari, Pietro, Jenab, Mazda, Andersen, Peter M, Wennberg, Patrik, Wareham, Nicholas, Katzke, Verena, Kaaks, Rudolf, Weiderpass, Elisabete, Peeters, Petra H, Mattiello, Amalia, Pala, Valeria, Barricante, Aurelio, Chirlaque, Maria-Dolores, Travier, Noémie, Travis, Ruth C, Sanchez, Maria-Jose, Pessah-Rasmussen, Hélène, Petersson, Jesper, Tjønneland, Anne, Tumino, Rosario, Quiros, Jose Ramon, Trichopoulou, Antonia, Kyrozis, Andreas, Oikonomidou, Despoina, Masala, Giovanna, Sacerdote, Carlotta, Arriola, Larraitz, Boeing, Heiner, Vigl, Matthaeus, Claver-Chapelon, Francoise, Middleton, Lefkos, Riboli, Elio, Vineis, Paolo, Gallo, Valentina, Vanacore, Nicola, Bueno-de-Mesquita, H Bas, Vermeulen, Roel, Brayne, Carol, Pearce, Neil, Wark, Petra A, Ward, Heather A, Ferrari, Pietro, Jenab, Mazda, Andersen, Peter M, Wennberg, Patrik, Wareham, Nicholas, Katzke, Verena, Kaaks, Rudolf, Weiderpass, Elisabete, Peeters, Petra H, Mattiello, Amalia, Pala, Valeria, Barricante, Aurelio, Chirlaque, Maria-Dolores, Travier, Noémie, Travis, Ruth C, Sanchez, Maria-Jose, Pessah-Rasmussen, Hélène, Petersson, Jesper, Tjønneland, Anne, Tumino, Rosario, Quiros, Jose Ramon, Trichopoulou, Antonia, Kyrozis, Andreas, Oikonomidou, Despoina, Masala, Giovanna, Sacerdote, Carlotta, Arriola, Larraitz, Boeing, Heiner, Vigl, Matthaeus, Claver-Chapelon, Francoise, Middleton, Lefkos, Riboli, Elio, and Vineis, Paolo

Abstract

Previous case-control studies have suggested a possible increased risk of Amyotrophic Lateral Sclerosis (ALS) with physical activity (PA), but this association has never been studied in prospective cohort studies. We therefore assessed the association between PA and risk of death from ALS in the European Prospective Investigation into Cancer and Nutrition. A total of 472,100 individuals were included in the analysis, yielding 219 ALS deaths. At recruitment, information on PA was collected thorough standardised questionnaires. Total PA was expressed by the Cambridge Physical Activity Index (CPAI) and analysed in relation to ALS mortality, using Cox hazard models. Interactions with age, sex, and anthropometric measures were assessed. Total PA was weakly inversely associated with ALS mortality with a borderline statistically significant trend across categories (p = 0.042), with those physically active being 33% less likely to die from ALS compared to those inactive: HR = 0.67 (95% CI 0.42-1.06). Anthropometric measures, sex, and age did not modify the association with CPAI. The present study shows a slightly decreased-not increased like in case-control studies-risk of dying from ALS in those with high levels of total PA at enrolment. This association does not appear confounded by age, gender, anthropometry, smoking, and education. Ours was the first prospective cohort study on ALS and physical activity.

Published
2016

28. The Influence of Hormonal Factors on the Risk of Developing Cervical Cancer and Pre-Cancer : Results from the EPIC Cohort

Author

Roura, Esther, Travier, Noémie, Waterboer, Tim, de Sanjosé, Silvia, Bosch, F Xavier, Pawlita, Michael, Pala, Valeria, Weiderpass, Elisabete, Margall, Núria, Dillner, Joakim, Gram, Inger T, Tjønneland, Anne, Munk, Christian, Palli, Domenico, Khaw, Kay-Tee, Overvad, Kim, Clavel-Chapelon, Françoise, Mesrine, Sylvie, Fournier, Agnès, Fortner, Renée T, Ose, Jennifer, Steffen, Annika, Trichopoulou, Antonia, Lagiou, Pagona, Orfanos, Philippos, Masala, Giovanna, Tumino, Rosario, Sacerdote, Carlotta, Polidoro, Silvia, Mattiello, Amalia, Lund, Eiliv, Peeters, Petra H, Bueno-de-Mesquita, H B(as), Quirós, J Ramón, Sánchez, María-José, Navarro, Carmen, Barricarte, Aurelio, Larrañaga, Nerea, Ekström, Johanna, Lindquist, David, Idahl, Annika, Travis, Ruth C, Merritt, Melissa A, Gunter, Marc J, Rinaldi, Sabina, Tommasino, Massimo, Franceschi, Silvia, Riboli, Elio, Castellsagué, Xavier, Roura, Esther, Travier, Noémie, Waterboer, Tim, de Sanjosé, Silvia, Bosch, F Xavier, Pawlita, Michael, Pala, Valeria, Weiderpass, Elisabete, Margall, Núria, Dillner, Joakim, Gram, Inger T, Tjønneland, Anne, Munk, Christian, Palli, Domenico, Khaw, Kay-Tee, Overvad, Kim, Clavel-Chapelon, Françoise, Mesrine, Sylvie, Fournier, Agnès, Fortner, Renée T, Ose, Jennifer, Steffen, Annika, Trichopoulou, Antonia, Lagiou, Pagona, Orfanos, Philippos, Masala, Giovanna, Tumino, Rosario, Sacerdote, Carlotta, Polidoro, Silvia, Mattiello, Amalia, Lund, Eiliv, Peeters, Petra H, Bueno-de-Mesquita, H B(as), Quirós, J Ramón, Sánchez, María-José, Navarro, Carmen, Barricarte, Aurelio, Larrañaga, Nerea, Ekström, Johanna, Lindquist, David, Idahl, Annika, Travis, Ruth C, Merritt, Melissa A, Gunter, Marc J, Rinaldi, Sabina, Tommasino, Massimo, Franceschi, Silvia, Riboli, Elio, and Castellsagué, Xavier

Abstract

Background: In addition to HPV, high parity and hormonal contraceptives have been associated with cervical cancer (CC). However, most of the evidence comes from retrospective case-control studies. The aim of this study is to prospectively evaluate associations between hormonal factors and risk of developing cervical intraepithelial neoplasia grade 3 (CIN3)/carcinoma in situ (CIS) and invasive cervical cancer (ICC). Methods and Findings: We followed a cohort of 308,036 women recruited in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study. At enrollment, participants completed a questionnaire and provided serum. After a 9-year median follow-up, 261 ICC and 804 CIN3/CIS cases were reported. In a nested case-control study, the sera from 609 cases and 1,218 matched controls were tested for L1 antibodies against HPV types 11,16,18,31,33,35,45, 52,58, and antibodies against Chlamydia trachomatis and Human herpesvirus 2. Multivariate analyses were performed to estimate hazard ratios (HR), odds ratios (OR) and corresponding 95% confidence intervals (CI). The cohort analysis showed that number of fullterm pregnancies was positively associated with CIN3/CIS risk (p-trend = 0.03). Duration of oral contraceptives use was associated with a significantly increased risk of both CIN3/CIS and ICC (HR = 1.6 and HR = 1.8 respectively for >= 15 years versus never use). Ever use of menopausal hormone therapy was associated with a reduced risk of ICC (HR = 0.5, 95% CI: 0.4-0.8). A non-significant reduced risk of ICC with ever use of intrauterine devices (IUD) was found in the nested case-control analysis (OR = 0.6). Analyses restricted to all cases and HPV seropositive controls yielded similar results, revealing a significant inverse association with IUD for combined CIN3/CIS and ICC (OR = 0.7). Conclusions: Even though HPV is the necessary cause of CC, our results suggest that several hormonal factors are risk factors for cervical carcinogenesis. Adherence t

Published
2016
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29. Plasma carotenoids, Vitamin C, tocopherols, and retinol and the risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition cohort

Author

Bakker, Marije F., Peeters, Petra H M, Klaasen, Veronique M., Bueno-De-Mesquita, H. Bas, Jansen, Eugene H J M, Ros, Martine M., Travier, Noémie, Olsen, Anja, Tjønneland, Anne, Overvad, Kim, Rinaldi, Sabina, Romieu, Isabelle, Brennan, Paul, Boutron-Ruault, Marie Christine, Perquier, Florence, Cadeau, Claire, Boeing, Heiner, Aleksandrova, Krasimira, Kaaks, Rudolf, Kühn, Tilman, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Vineis, Paolo, Krogh, Vittorio, Panico, Salvatore, Masala, Giovanna, Tumino, Rosario, Weiderpass, Elisabete, Skeie, Guri, Lund, Eiliv, Quirós, J. Ramón, Ardanaz, Eva, Navarro, Carmen, Amiano, Pilar, Sánchez, María José, Buckland, Genevieve, Ericson, Ulrika, Sonestedt, Emily, Johansson, Matthias, Sund, Malin, Travis, Ruth C., Key, Timothy J., Khaw, Kay Tee, Wareham, Nick, Riboli, Elio, Van Gils, Carla H., Bakker, Marije F., Peeters, Petra H M, Klaasen, Veronique M., Bueno-De-Mesquita, H. Bas, Jansen, Eugene H J M, Ros, Martine M., Travier, Noémie, Olsen, Anja, Tjønneland, Anne, Overvad, Kim, Rinaldi, Sabina, Romieu, Isabelle, Brennan, Paul, Boutron-Ruault, Marie Christine, Perquier, Florence, Cadeau, Claire, Boeing, Heiner, Aleksandrova, Krasimira, Kaaks, Rudolf, Kühn, Tilman, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Vineis, Paolo, Krogh, Vittorio, Panico, Salvatore, Masala, Giovanna, Tumino, Rosario, Weiderpass, Elisabete, Skeie, Guri, Lund, Eiliv, Quirós, J. Ramón, Ardanaz, Eva, Navarro, Carmen, Amiano, Pilar, Sánchez, María José, Buckland, Genevieve, Ericson, Ulrika, Sonestedt, Emily, Johansson, Matthias, Sund, Malin, Travis, Ruth C., Key, Timothy J., Khaw, Kay Tee, Wareham, Nick, Riboli, Elio, and Van Gils, Carla H.

Published
2016

30. Physical activity and risk of Amyotrophic Lateral Sclerosis in a prospective cohort study

Author

LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-I&I RA, dIRAS RA-2, Gallo, Valentina, Vanacore, Nicola, Bueno-de-Mesquita, H Bas, Vermeulen, Roel, Brayne, Carol, Pearce, Neil, Wark, Petra A, Ward, Heather A, Ferrari, Pietro, Jenab, Mazda, Andersen, Peter M, Wennberg, Patrik, Wareham, Nicholas, Katzke, Verena, Kaaks, Rudolf, Weiderpass, Elisabete, Peeters, Petra H, Mattiello, Amalia, Pala, Valeria, Barricante, Aurelio, Chirlaque, Maria-Dolores, Travier, Noémie, Travis, Ruth C, Sanchez, Maria-Jose, Pessah-Rasmussen, Hélène, Petersson, Jesper, Tjønneland, Anne, Tumino, Rosario, Quiros, Jose Ramon, Trichopoulou, Antonia, Kyrozis, Andreas, Oikonomidou, Despoina, Masala, Giovanna, Sacerdote, Carlotta, Arriola, Larraitz, Boeing, Heiner, Vigl, Matthaeus, Claver-Chapelon, Francoise, Middleton, Lefkos, Riboli, Elio, Vineis, Paolo, LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-I&I RA, dIRAS RA-2, Gallo, Valentina, Vanacore, Nicola, Bueno-de-Mesquita, H Bas, Vermeulen, Roel, Brayne, Carol, Pearce, Neil, Wark, Petra A, Ward, Heather A, Ferrari, Pietro, Jenab, Mazda, Andersen, Peter M, Wennberg, Patrik, Wareham, Nicholas, Katzke, Verena, Kaaks, Rudolf, Weiderpass, Elisabete, Peeters, Petra H, Mattiello, Amalia, Pala, Valeria, Barricante, Aurelio, Chirlaque, Maria-Dolores, Travier, Noémie, Travis, Ruth C, Sanchez, Maria-Jose, Pessah-Rasmussen, Hélène, Petersson, Jesper, Tjønneland, Anne, Tumino, Rosario, Quiros, Jose Ramon, Trichopoulou, Antonia, Kyrozis, Andreas, Oikonomidou, Despoina, Masala, Giovanna, Sacerdote, Carlotta, Arriola, Larraitz, Boeing, Heiner, Vigl, Matthaeus, Claver-Chapelon, Francoise, Middleton, Lefkos, Riboli, Elio, and Vineis, Paolo

Published
2016

31. Effects of an Exercise Program in Colon Cancer Patients Undergoing Chemotherapy

Author

JC onderzoeksprogramma Kanker, RF&S Team 2 Medisch, Brain, MS Medische Oncologie, Cancer, Epi Kanker Team 1, van Vulpen, Jonna K., Velthuis, Miranda J., Steins Bisschop, Charlotte N., Travier, Noémie, van den Buijs, Bram J W, Backx, Frank J G, Los, Maartje, Erdkamp, Frans L G, Bloemendal, Haiko J., Koopman, Miriam, de Roos, Marnix A J, Verhaar, Marlies J., ten Bokkel-Huinink, Daan, van der Wall, Elsken, Peeters, Petra H M, May, Anne M., JC onderzoeksprogramma Kanker, RF&S Team 2 Medisch, Brain, MS Medische Oncologie, Cancer, Epi Kanker Team 1, van Vulpen, Jonna K., Velthuis, Miranda J., Steins Bisschop, Charlotte N., Travier, Noémie, van den Buijs, Bram J W, Backx, Frank J G, Los, Maartje, Erdkamp, Frans L G, Bloemendal, Haiko J., Koopman, Miriam, de Roos, Marnix A J, Verhaar, Marlies J., ten Bokkel-Huinink, Daan, van der Wall, Elsken, Peeters, Petra H M, and May, Anne M.

Published
2016

32. Main nutrient patterns are associated with prospective weight change in adults from 10 European countries

Author

Infection & Immunity, Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Freisling, Heinz, Pisa, Pedro T., Ferrari, Pietro, Byrnes, Graham, Moskal, Aurelie, Dahm, Christina C., Vergnaud, Anne Claire, Boutron-Ruault, Marie Christine, Fagherazzi, Guy, Cadeau, Claire, Kühn, Tilman, Neamat-Allah, Jasmine, Buijsse, Brian, Boeing, Heiner, Halkjær, Jytte, Tjonneland, Anne, Hansen, Camilla P., Quirós, J. Ramón, Travier, Noémie, Molina-Montes, Esther, Amiano, Pilar, Huerta, José M., Barricarte, Aurelio, Khaw, Kay Tee, Wareham, Nicholas, Key, Tim J., Romaguera, Dora, Lu, Yunxia, Lassale, Camille M., Naska, Androniki, Orfanos, Philippos, Trichopoulou, Antonia, Masala, Giovanna, Pala, Valeria, Berrino, Franco, Tumino, Rosario, Ricceri, Fulvio, de Magistris, Maria Santucci, Bueno-de-Mesquita, H. Bas, Ocké, Marga C., Sonestedt, Emily, Ericson, Ulrika, Johansson, Mattias, Skeie, Guri, Weiderpass, Elisabete, Braaten, Tonje, Peeters, Petra H M, Slimani, Nadia, Infection & Immunity, Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Freisling, Heinz, Pisa, Pedro T., Ferrari, Pietro, Byrnes, Graham, Moskal, Aurelie, Dahm, Christina C., Vergnaud, Anne Claire, Boutron-Ruault, Marie Christine, Fagherazzi, Guy, Cadeau, Claire, Kühn, Tilman, Neamat-Allah, Jasmine, Buijsse, Brian, Boeing, Heiner, Halkjær, Jytte, Tjonneland, Anne, Hansen, Camilla P., Quirós, J. Ramón, Travier, Noémie, Molina-Montes, Esther, Amiano, Pilar, Huerta, José M., Barricarte, Aurelio, Khaw, Kay Tee, Wareham, Nicholas, Key, Tim J., Romaguera, Dora, Lu, Yunxia, Lassale, Camille M., Naska, Androniki, Orfanos, Philippos, Trichopoulou, Antonia, Masala, Giovanna, Pala, Valeria, Berrino, Franco, Tumino, Rosario, Ricceri, Fulvio, de Magistris, Maria Santucci, Bueno-de-Mesquita, H. Bas, Ocké, Marga C., Sonestedt, Emily, Ericson, Ulrika, Johansson, Mattias, Skeie, Guri, Weiderpass, Elisabete, Braaten, Tonje, Peeters, Petra H M, and Slimani, Nadia

Published
2016

33. The Influence of Hormonal Factors on the Risk of Developing Cervical Cancer and Pre-Cancer: Results from the EPIC Cohort

Author

Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Infection & Immunity, Roura, Esther, Travier, Noémie, Waterboer, Tim, de Sanjosé, Silvia, Bosch, F Xavier, Pawlita, Michael, Pala, Valeria, Weiderpass, Elisabete, Margall, Núria, Dillner, Joakim, Gram, Inger T, Tjønneland, Anne, Munk, Christian, Palli, Domenico, Khaw, Kay-Tee, Overvad, Kim, Clavel-Chapelon, Françoise, Mesrine, Sylvie, Fournier, Agnès, Fortner, Renée T, Ose, Jennifer, Steffen, Annika, Trichopoulou, Antonia, Lagiou, Pagona, Orfanos, Philippos, Masala, Giovanna, Tumino, Rosario, Sacerdote, Carlotta, Polidoro, Silvia, Mattiello, Amalia, Lund, Eiliv, Peeters, Petra H, Bueno de Mesquita, H B(as)., Quirós, J Ramón, Sánchez, María-José, Navarro, Carmen, Barricarte, Aurelio, Larrañaga, Nerea, Ekström, Johanna, Lindquist, David, Idahl, Annika, Travis, Ruth C, Merritt, Melissa A, Gunter, Marc J, Rinaldi, Sabina, Tommasino, Massimo, Franceschi, Silvia, Riboli, Elio, Castellsagué, Xavier, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Infection & Immunity, Roura, Esther, Travier, Noémie, Waterboer, Tim, de Sanjosé, Silvia, Bosch, F Xavier, Pawlita, Michael, Pala, Valeria, Weiderpass, Elisabete, Margall, Núria, Dillner, Joakim, Gram, Inger T, Tjønneland, Anne, Munk, Christian, Palli, Domenico, Khaw, Kay-Tee, Overvad, Kim, Clavel-Chapelon, Françoise, Mesrine, Sylvie, Fournier, Agnès, Fortner, Renée T, Ose, Jennifer, Steffen, Annika, Trichopoulou, Antonia, Lagiou, Pagona, Orfanos, Philippos, Masala, Giovanna, Tumino, Rosario, Sacerdote, Carlotta, Polidoro, Silvia, Mattiello, Amalia, Lund, Eiliv, Peeters, Petra H, Bueno de Mesquita, H B(as)., Quirós, J Ramón, Sánchez, María-José, Navarro, Carmen, Barricarte, Aurelio, Larrañaga, Nerea, Ekström, Johanna, Lindquist, David, Idahl, Annika, Travis, Ruth C, Merritt, Melissa A, Gunter, Marc J, Rinaldi, Sabina, Tommasino, Massimo, Franceschi, Silvia, Riboli, Elio, and Castellsagué, Xavier

Published
2016

34. Correction: The Influence of Hormonal Factors on the Risk of Developing Cervical Cancer and Pre-Cancer: Results from the EPIC Cohort

Author

Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Infection & Immunity, Roura, Esther, Travier, Noémie, Waterboer, Tim, De Sanjosé, Silvia, Bosch, F. Xavier, Pawlita, Michael, Pala, Valeria, Weiderpass, Elisabete, Margall, Núria, Dillner, Joakim, Tjønneland, Anne, Munk, Christian, Khaw, Kay Tee, Overvad, Kim, Clavel-Chapelon, Françoise, Mesrine, Sylvie, Fournier, Agnès, Fortner, Renée T., Ose, Jennifer, Steffen, Annika, Trichopoulou, Antonia, Lagiou, Pagona, Orfanos, Philippos, Masala, Giovanna, Tumino, Rosario, Sacerdote, Carlotta, Polidoro, Silvia, Mattiello, Amalia, Lund, Eiliv, Peeters, Petra H., Bueno-De-Mesquita, H. B., Ramón Quirós, J., Sánchez, María José, Navarro, Carmen, Barricarte, Aurelio, Larrañaga, Nerea, Ekström, Johanna, Lindquist, David, Idahl, Annika, Travis, Ruth C., Merritt, Melissa A., Gunter, Marc J., Rinaldi, Sabina, Tommasino, Massimo, Franceschi, Silvia, Riboli, Elio, Castellsagué, Xavier, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Infection & Immunity, Roura, Esther, Travier, Noémie, Waterboer, Tim, De Sanjosé, Silvia, Bosch, F. Xavier, Pawlita, Michael, Pala, Valeria, Weiderpass, Elisabete, Margall, Núria, Dillner, Joakim, Tjønneland, Anne, Munk, Christian, Khaw, Kay Tee, Overvad, Kim, Clavel-Chapelon, Françoise, Mesrine, Sylvie, Fournier, Agnès, Fortner, Renée T., Ose, Jennifer, Steffen, Annika, Trichopoulou, Antonia, Lagiou, Pagona, Orfanos, Philippos, Masala, Giovanna, Tumino, Rosario, Sacerdote, Carlotta, Polidoro, Silvia, Mattiello, Amalia, Lund, Eiliv, Peeters, Petra H., Bueno-De-Mesquita, H. B., Ramón Quirós, J., Sánchez, María José, Navarro, Carmen, Barricarte, Aurelio, Larrañaga, Nerea, Ekström, Johanna, Lindquist, David, Idahl, Annika, Travis, Ruth C., Merritt, Melissa A., Gunter, Marc J., Rinaldi, Sabina, Tommasino, Massimo, Franceschi, Silvia, Riboli, Elio, and Castellsagué, Xavier

Published
2016

35. Physical activity and risk of Amyotrophic Lateral Sclerosis in a prospective cohort study

Author

Infection & Immunity, Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Gallo, Valentina, Vanacore, Nicola, Bueno-de-Mesquita, H. Bas, Vermeulen, Roel, Brayne, Carol, Pearce, Neil, Wark, Petra A., Ward, Heather A., Ferrari, Pietro, Jenab, Mazda, Andersen, Peter M., Wennberg, Patrik, Wareham, Nicholas, Katzke, Verena, Kaaks, Rudolf, Weiderpass, Elisabete, Peeters, Petra H., Mattiello, Amalia, Pala, Valeria, Barricante, Aurelio, Chirlaque, Maria Dolores, Travier, Noémie, Travis, Ruth C., Sanchez, Maria Jose, Pessah-Rasmussen, Hélène, Petersson, Jesper, Tjønneland, Anne, Tumino, Rosario, Quiros, Jose Ramon, Trichopoulou, Antonia, Kyrozis, Andreas, Oikonomidou, Despoina, Masala, Giovanna, Sacerdote, Carlotta, Arriola, Larraitz, Boeing, Heiner, Vigl, Matthaeus, Claver-Chapelon, Francoise, Middleton, Lefkos, Riboli, Elio, Vineis, Paolo, Infection & Immunity, Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Gallo, Valentina, Vanacore, Nicola, Bueno-de-Mesquita, H. Bas, Vermeulen, Roel, Brayne, Carol, Pearce, Neil, Wark, Petra A., Ward, Heather A., Ferrari, Pietro, Jenab, Mazda, Andersen, Peter M., Wennberg, Patrik, Wareham, Nicholas, Katzke, Verena, Kaaks, Rudolf, Weiderpass, Elisabete, Peeters, Petra H., Mattiello, Amalia, Pala, Valeria, Barricante, Aurelio, Chirlaque, Maria Dolores, Travier, Noémie, Travis, Ruth C., Sanchez, Maria Jose, Pessah-Rasmussen, Hélène, Petersson, Jesper, Tjønneland, Anne, Tumino, Rosario, Quiros, Jose Ramon, Trichopoulou, Antonia, Kyrozis, Andreas, Oikonomidou, Despoina, Masala, Giovanna, Sacerdote, Carlotta, Arriola, Larraitz, Boeing, Heiner, Vigl, Matthaeus, Claver-Chapelon, Francoise, Middleton, Lefkos, Riboli, Elio, and Vineis, Paolo

Published
2016

36. Plasma carotenoids, Vitamin C, tocopherols, and retinol and the risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition cohort

Author

Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Epi Kanker Team 1, Infection & Immunity, Bakker, Marije F., Peeters, Petra H M, Klaasen, Veronique M., Bueno-De-Mesquita, H. Bas, Jansen, Eugene H J M, Ros, Martine M., Travier, Noémie, Olsen, Anja, Tjønneland, Anne, Overvad, Kim, Rinaldi, Sabina, Romieu, Isabelle, Brennan, Paul, Boutron-Ruault, Marie Christine, Perquier, Florence, Cadeau, Claire, Boeing, Heiner, Aleksandrova, Krasimira, Kaaks, Rudolf, Kühn, Tilman, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Vineis, Paolo, Krogh, Vittorio, Panico, Salvatore, Masala, Giovanna, Tumino, Rosario, Weiderpass, Elisabete, Skeie, Guri, Lund, Eiliv, Quirós, J. Ramón, Ardanaz, Eva, Navarro, Carmen, Amiano, Pilar, Sánchez, María José, Buckland, Genevieve, Ericson, Ulrika, Sonestedt, Emily, Johansson, Matthias, Sund, Malin, Travis, Ruth C., Key, Timothy J., Khaw, Kay Tee, Wareham, Nick, Riboli, Elio, Van Gils, Carla H., Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Epi Kanker Team 1, Infection & Immunity, Bakker, Marije F., Peeters, Petra H M, Klaasen, Veronique M., Bueno-De-Mesquita, H. Bas, Jansen, Eugene H J M, Ros, Martine M., Travier, Noémie, Olsen, Anja, Tjønneland, Anne, Overvad, Kim, Rinaldi, Sabina, Romieu, Isabelle, Brennan, Paul, Boutron-Ruault, Marie Christine, Perquier, Florence, Cadeau, Claire, Boeing, Heiner, Aleksandrova, Krasimira, Kaaks, Rudolf, Kühn, Tilman, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Vineis, Paolo, Krogh, Vittorio, Panico, Salvatore, Masala, Giovanna, Tumino, Rosario, Weiderpass, Elisabete, Skeie, Guri, Lund, Eiliv, Quirós, J. Ramón, Ardanaz, Eva, Navarro, Carmen, Amiano, Pilar, Sánchez, María José, Buckland, Genevieve, Ericson, Ulrika, Sonestedt, Emily, Johansson, Matthias, Sund, Malin, Travis, Ruth C., Key, Timothy J., Khaw, Kay Tee, Wareham, Nick, Riboli, Elio, and Van Gils, Carla H.

Published
2016

37. Identifying high-risk individuals for lung cancer screening: Going beyond NLST criteria.

Author

Fu, Marcela, Travier, Noémie, Martín-Sánchez, Juan Carlos, Martínez-Sánchez, Jose M., Vidal, Carmen, Garcia, Montse, and null, null

Subjects
*LUNG cancer, *CANCER diagnosis, *EARLY detection of cancer, *OBSTRUCTIVE lung diseases, *DIAGNOSTIC imaging, *PREDICTION models
Abstract

Background: There are two main types of strategies to identify target population for lung cancer screening: 1) strategies based on age and cumulative smoking criteria, 2) risk prediction models allowing the calculation of an individual risk. The objective of this study was to compare different strategies to identify the proportion of the Spanish population at high risk of developing lung cancer, susceptible to be included in a lung cancer screening programme. Methods: Cross-sectional study. We used the data of the Spanish National Interview Health Survey (ENSE) of 2011–2012 (21,006 individuals) to estimate the proportion of participants at high risk of developing lung cancer. This estimation was performed using the U.S. national lung screening trial (NLST) criteria and a 6-year prediction model (PLCOm2012), both independently and in combination. Results: The prevalence of individuals at high risk of developing lung cancer according to the NLST criteria was 4.9% (7.9% for men, 2.4% for women). Among the 1,034 subjects who met the NLST criteria, 533 (427 men and 106 women) had a 6-year lung cancer risk ≥2.0%. The combination of these two selection strategies showed that 2.5% of the Spanish population had a high risk of developing lung cancer. However, this selection process did not take into account different groups of subjects <75 years old having an individual risk of lung cancer ≥2%, such as heavy smokers <55 years old who were long-time former smokers, and ever-smokers having smoked <30 pack-years with other risk factors. Conclusions: Further research is needed to determine which selection strategy achieves a higher benefit/harm ratio and to assess other prevention strategies for individuals with elevated risk for lung cancer but who do not meet the screening eligibility criteria. [ABSTRACT FROM AUTHOR]

Published
2018
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38. The Influence of Hormonal Factors on the Risk of Developing Cervical Cancer and Pre-Cancer: Results from the EPIC Cohort

Author

Roura, Esther, primary, Travier, Noémie, additional, Waterboer, Tim, additional, de Sanjosé, Silvia, additional, Bosch, F. Xavier, additional, Pawlita, Michael, additional, Pala, Valeria, additional, Weiderpass, Elisabete, additional, Margall, Núria, additional, Dillner, Joakim, additional, Gram, Inger T., additional, Tjønneland, Anne, additional, Munk, Christian, additional, Palli, Domenico, additional, Khaw, Kay-Tee, additional, Overvad, Kim, additional, Clavel-Chapelon, Françoise, additional, Mesrine, Sylvie, additional, Fournier, Agnès, additional, Fortner, Renée T., additional, Ose, Jennifer, additional, Steffen, Annika, additional, Trichopoulou, Antonia, additional, Lagiou, Pagona, additional, Orfanos, Philippos, additional, Masala, Giovanna, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Polidoro, Silvia, additional, Mattiello, Amalia, additional, Lund, Eiliv, additional, Peeters, Petra H., additional, Bueno-de-Mesquita, H. B(as)., additional, Quirós, J. Ramón, additional, Sánchez, María-José, additional, Navarro, Carmen, additional, Barricarte, Aurelio, additional, Larrañaga, Nerea, additional, Ekström, Johanna, additional, Lindquist, David, additional, Idahl, Annika, additional, Travis, Ruth C., additional, Merritt, Melissa A., additional, Gunter, Marc J., additional, Rinaldi, Sabina, additional, Tommasino, Massimo, additional, Franceschi, Silvia, additional, Riboli, Elio, additional, and Castellsagué, Xavier, additional

Published
2016
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39. Pre-diagnostic polyphenol intake and breast cancer survival : the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author

Kyrø, Cecilie, Zamora-Ros, Raul, Scalbert, Augustin, Tjønneland, Anne, Dossus, Laure, Johansen, Christoffer, Bidstrup, Pernille Envold, Weiderpass, Elisabete, Christensen, Jane, Ward, Heather, Aune, Dagfinn, Riboli, Elio, His, Mathilde, Clavel-Chapelon, Françoise, Baglietto, Laura, Katzke, Verena, Kühn, Tilman, Boeing, Heiner, Floegel, Anna, Overvad, Kim, Lasheras, Cristina, Travier, Noémie, Sánchez, Maria-José, Amiano, Pilar, Chirlaque, Maria-Dolores, Ardanaz, Eva, Khaw, Kay-Tee, Wareham, Nick, Perez-Cornago, Aurora, Trichopoulou, Antonia, Lagiou, Pagona, Vasilopoulou, Effie, Masala, Giovanna, Grioni, Sara, Berrino, Franco, Tumino, Rosario, Sacerdote, Carlotta, Mattiello, Amalia, Bueno-de-Mesquita, H B(as), Peeters, Petra H, van Gils, Carla, Borgquist, Signe, Butt, Salma, Zeleniuch-Jacquotte, Anne, Sund, Malin, Hjartåker, Anette, Skeie, Guri, Olsen, Anja, Romieu, Isabelle, Kyrø, Cecilie, Zamora-Ros, Raul, Scalbert, Augustin, Tjønneland, Anne, Dossus, Laure, Johansen, Christoffer, Bidstrup, Pernille Envold, Weiderpass, Elisabete, Christensen, Jane, Ward, Heather, Aune, Dagfinn, Riboli, Elio, His, Mathilde, Clavel-Chapelon, Françoise, Baglietto, Laura, Katzke, Verena, Kühn, Tilman, Boeing, Heiner, Floegel, Anna, Overvad, Kim, Lasheras, Cristina, Travier, Noémie, Sánchez, Maria-José, Amiano, Pilar, Chirlaque, Maria-Dolores, Ardanaz, Eva, Khaw, Kay-Tee, Wareham, Nick, Perez-Cornago, Aurora, Trichopoulou, Antonia, Lagiou, Pagona, Vasilopoulou, Effie, Masala, Giovanna, Grioni, Sara, Berrino, Franco, Tumino, Rosario, Sacerdote, Carlotta, Mattiello, Amalia, Bueno-de-Mesquita, H B(as), Peeters, Petra H, van Gils, Carla, Borgquist, Signe, Butt, Salma, Zeleniuch-Jacquotte, Anne, Sund, Malin, Hjartåker, Anette, Skeie, Guri, Olsen, Anja, and Romieu, Isabelle

Abstract

The aim was to investigate the association between pre-diagnostic intakes of polyphenol classes (flavonoids, lignans, phenolic acids, stilbenes, and other polyphenols) in relation to breast cancer survival (all-cause and breast cancer-specific mortality). We used data from the European Prospective Investigation into Cancer and Nutrition cohort. Pre-diagnostic usual diet was assessed using dietary questionnaires, and polyphenol intakes were estimated using the Phenol-Explorer database. We followed 11,782 breast cancer cases from time of diagnosis until death, end of follow-up or last day of contact. During a median of 6 years, 1482 women died (753 of breast cancer). We related polyphenol intake to all-cause and breast cancer-specific mortality using Cox proportional hazard models with time since diagnosis as underlying time and strata for age and country. Among postmenopausal women, an intake of lignans in the highest versus lowest quartile was related to a 28 % lower risk of dying from breast (adjusted model: HR, quartile 4 vs. quartile 1, 0.72, 95 % CI 0.53; 0.98). In contrast, in premenopausal women, a positive association between lignan intake and all-cause mortality was found (adjusted model: HR, quartile 4 vs. quartile 1, 1.63, 95 % CI 1.03; 2.57). We found no association for other polyphenol classes. Intake of lignans before breast cancer diagnosis may be related to improved survival among postmenopausal women, but may on the contrary worsen the survival for premenopausal women. This suggests that the role of phytoestrogens in breast cancer survival is complex and may be dependent of menopausal status.

Published
2015
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40. Pre-diagnostic polyphenol intake and breast cancer survival: the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author

Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, MS MDL 1, Infection & Immunity, Epi Kanker Team A, Kyrø, Cecilie, Zamora-Ros, Raul, Scalbert, Augustin, Tjønneland, Anne, Dossus, Laure, Johansen, Christoffer, Bidstrup, Pernille Envold, Weiderpass, Elisabete, Christensen, Jane, Ward, Heather, Aune, Dagfinn, Riboli, Elio, His, Mathilde, Clavel-Chapelon, Françoise, Baglietto, Laura, Katzke, Verena, Kühn, Tilman, Boeing, Heiner, Floegel, Anna, Overvad, Kim, Lasheras, Cristina, Travier, Noémie, Sánchez, Maria José, Amiano, Pilar, Chirlaque, Maria Dolores, Ardanaz, Eva, Khaw, Kay Tee, Wareham, Nick, Perez-Cornago, Aurora, Trichopoulou, Antonia, Lagiou, Pagona, Vasilopoulou, Effie, Masala, Giovanna, Grioni, Sara, Berrino, Franco, Tumino, Rosario, Sacerdote, Carlotta, Mattiello, Amalia, Bueno-de-Mesquita, H. B., Peeters, Petra H., van Gils, Carla, Borgquist, Signe, Butt, Salma, Zeleniuch-Jacquotte, Anne, Sund, Malin, Hjartåker, Anette, Skeie, Guri, Olsen, Anja, Romieu, Isabelle, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, MS MDL 1, Infection & Immunity, Epi Kanker Team A, Kyrø, Cecilie, Zamora-Ros, Raul, Scalbert, Augustin, Tjønneland, Anne, Dossus, Laure, Johansen, Christoffer, Bidstrup, Pernille Envold, Weiderpass, Elisabete, Christensen, Jane, Ward, Heather, Aune, Dagfinn, Riboli, Elio, His, Mathilde, Clavel-Chapelon, Françoise, Baglietto, Laura, Katzke, Verena, Kühn, Tilman, Boeing, Heiner, Floegel, Anna, Overvad, Kim, Lasheras, Cristina, Travier, Noémie, Sánchez, Maria José, Amiano, Pilar, Chirlaque, Maria Dolores, Ardanaz, Eva, Khaw, Kay Tee, Wareham, Nick, Perez-Cornago, Aurora, Trichopoulou, Antonia, Lagiou, Pagona, Vasilopoulou, Effie, Masala, Giovanna, Grioni, Sara, Berrino, Franco, Tumino, Rosario, Sacerdote, Carlotta, Mattiello, Amalia, Bueno-de-Mesquita, H. B., Peeters, Petra H., van Gils, Carla, Borgquist, Signe, Butt, Salma, Zeleniuch-Jacquotte, Anne, Sund, Malin, Hjartåker, Anette, Skeie, Guri, Olsen, Anja, and Romieu, Isabelle

Published
2015

41. Effects of an 18-week exercise programme started early during breast cancer treatment: a randomised controlled trial

Author

Travier, Noémie, primary, Velthuis, Miranda J., additional, Steins Bisschop, Charlotte N., additional, van den Buijs, Bram, additional, Monninkhof, Evelyn M., additional, Backx, Frank, additional, Los, Maartje, additional, Erdkamp, Frans, additional, Bloemendal, Haiko J., additional, Rodenhuis, Carla, additional, de Roos, Marnix A.J., additional, Verhaar, Marlies, additional, ten Bokkel Huinink, Daan, additional, van der Wall, Elsken, additional, Peeters, Petra H.M., additional, and May, Anne M., additional

Published
2015
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42. Smoking as a major risk factor for cervical cancer and pre-cancer : results from the EPIC cohort

Author

Roura, Esther, Castellsagué, Xavier, Pawlita, Michael, Travier, Noémie, Waterboer, Tim, Margall, Núria, Bosch, F Xavier, de Sanjosé, Silvia, Dillner, Joakim, Gram, Inger T, Tjønneland, Anne, Munk, Christian, Pala, Valeria, Palli, Domenico, Khaw, Kay-Tee, Barnabas, Ruanne V, Overvad, Kim, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, Kaaks, Rudolf, Lukanova, Annekatrin, Steffen, Annika, Trichopoulou, Antonia, Trichopoulos, Dimitrios, Klinaki, Eleni, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, Bueno-de-Mesquita, H Bas, Peeters, Petra H, Lund, Eiliv, Weiderpass, Elisabete, Redondo, M Luisa, Sánchez, María-José, Tormo, Maria-José, Barricarte, Aurelio, Larrañaga, Nerea, Ekström, Johanna, Hortlund, Maria, Lindquist, David, Wareham, Nick, Travis, Ruth C, Rinaldi, Sabina, Tommasino, Massimo, Franceschi, Silvia, Riboli, Elio, Roura, Esther, Castellsagué, Xavier, Pawlita, Michael, Travier, Noémie, Waterboer, Tim, Margall, Núria, Bosch, F Xavier, de Sanjosé, Silvia, Dillner, Joakim, Gram, Inger T, Tjønneland, Anne, Munk, Christian, Pala, Valeria, Palli, Domenico, Khaw, Kay-Tee, Barnabas, Ruanne V, Overvad, Kim, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, Kaaks, Rudolf, Lukanova, Annekatrin, Steffen, Annika, Trichopoulou, Antonia, Trichopoulos, Dimitrios, Klinaki, Eleni, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, Bueno-de-Mesquita, H Bas, Peeters, Petra H, Lund, Eiliv, Weiderpass, Elisabete, Redondo, M Luisa, Sánchez, María-José, Tormo, Maria-José, Barricarte, Aurelio, Larrañaga, Nerea, Ekström, Johanna, Hortlund, Maria, Lindquist, David, Wareham, Nick, Travis, Ruth C, Rinaldi, Sabina, Tommasino, Massimo, Franceschi, Silvia, and Riboli, Elio

Abstract

A total of 308,036 women were selected from the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate the association between tobacco smoking and the risk of cervical intraepithelial neoplasia grade 3 (CIN3)/carcinoma in situ (CIS) and invasive cervical cancer (ICC). At baseline, participants completed a questionnaire and provided blood samples. During a mean follow-up time of 9 years, 261 ICC cases and 804 CIN3/CIS cases were reported. In a nested case-control study, the baseline sera from 609 cases and 1,218 matched controls were tested for L1 antibodies against HPV types 11,16,18,31,33,35,45,52,58, and antibodies against Chlamydia trachomatis (CT), and Human Herpes Virus 2 (HHV-2). Cervical samples were not available for HPV-DNA analysis in this study. Multivariate analyses were used to estimate associations between smoking and risk of CIN3/CIS and ICC in the cohort and the case-control studies. In the cohort analyses smoking status, duration and intensity showed a 2-fold increased risk of CIN3/CIS and ICC, while time since quitting was associated with a 2-fold reduced risk. In the nested case-control study, consistent associations were observed after adjustment for HPV, CT and HHV-2 serostatus, in both HPV seronegative and seropositive women. Results from this large prospective study confirm the role of tobacco smoking as an important risk factor for both CIN3/CIS and ICC, even after taking into account HPV exposure as determined by HPV serology. The strong beneficial effect of quitting smoking is an important finding that will further support public health policies for smoking cessation.

Published
2014
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44. Abdominal obesity, weight gain during adulthood and risk of liver and biliary tract cancer in a European cohort

Author

Schlesinger, Sabrina, Aleksandrova, Krasimira, Pischon, Tobias, Fedirko, Veronika, Jenab, Mazda, Trepo, Elisabeth, Boffetta, Paolo, Dahm, Christina C, Overvad, Kim, Tjønneland, Anne, Halkjaer, Jytte, Fagherazzi, Guy, Boutron-Ruault, Marie-Christine, Carbonnel, Franck, Kaaks, Rudolf, Lukanova, Annekatrin, Boeing, Heiner, Trichopoulou, Antonia, Bamia, Christina, Lagiou, Pagona, Palli, Domenico, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Vineis, Paolo, Bueno-de-Mesquita, HB, van den Berg, Saskia, Peeters, Petra HM, Braaten, Tonje, Weiderpass, Elisabete, Quirós, J Ramón, Travier, Noémie, Sánchez, María-José, Navarro, Carmen, Barricarte, Aurelio, Dorronsoro, Miren, Lindkvist, Björn, Regner, Sara, Werner, Mårten, Sund, Malin, Khaw, Kay-Tee, Wareham, Nicholas, Travis, Ruth C, Norat, Teresa, Wark, Petra A, Riboli, Elio, Nöthlings, Ute, Schlesinger, Sabrina, Aleksandrova, Krasimira, Pischon, Tobias, Fedirko, Veronika, Jenab, Mazda, Trepo, Elisabeth, Boffetta, Paolo, Dahm, Christina C, Overvad, Kim, Tjønneland, Anne, Halkjaer, Jytte, Fagherazzi, Guy, Boutron-Ruault, Marie-Christine, Carbonnel, Franck, Kaaks, Rudolf, Lukanova, Annekatrin, Boeing, Heiner, Trichopoulou, Antonia, Bamia, Christina, Lagiou, Pagona, Palli, Domenico, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Vineis, Paolo, Bueno-de-Mesquita, HB, van den Berg, Saskia, Peeters, Petra HM, Braaten, Tonje, Weiderpass, Elisabete, Quirós, J Ramón, Travier, Noémie, Sánchez, María-José, Navarro, Carmen, Barricarte, Aurelio, Dorronsoro, Miren, Lindkvist, Björn, Regner, Sara, Werner, Mårten, Sund, Malin, Khaw, Kay-Tee, Wareham, Nicholas, Travis, Ruth C, Norat, Teresa, Wark, Petra A, Riboli, Elio, and Nöthlings, Ute

Abstract

General obesity has been positively associated with risk of liver and probably with biliary tract cancer, but little is known about abdominal obesity or weight gain during adulthood. We used multivariable Cox proportional hazard models to investigate associations between weight, body mass index, waist and hip circumference, waist-to-hip and waist-to-height ratio (WHtR), weight change during adulthood and risk of hepatocellular carcinoma (HCC), intrahepatic (IBDC) and extrahepatic bile duct system cancer [EBDSC including gallbladder cancer (GBC)] among 359,525 men and women in the European Prospective Investigation into Cancer and Nutrition study. Hepatitis B and C virus status was measured in a nested case-control subset. During a mean follow-up of 8.6 years, 177 cases of HCC, 58 cases of IBDC and 210 cases of EBDSC, including 76 cases of GBC, occurred. All anthropometric measures were positively associated with risk of HCC and GBC. WHtR showed the strongest association with HCC [relative risk (RR) comparing extreme tertiles 3.51, 95% confidence interval (95% CI): 2.09-5.87; p(trend) < 0.0001] and with GBC (RR: 1.56, 95% CI: 1.12-2.16 for an increment of one unit in WHtR). Weight gain during adulthood was also positively associated with HCC when comparing extreme tertiles (RR: 2.48, 95% CI: 1.49-4.13; <0.001). No statistically significant association was observed between obesity and risk of IBDC and EBDSC. Our results provide evidence of an association between obesity, particularly abdominal obesity, and risk of HCC and GBC. Our findings support public health recommendations to reduce the prevalence of obesity and weight gain in adulthood for HCC and GBC prevention in Western populations.

Published
2013
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45. Plasma phospholipid long-chain n-3 polyunsaturated fatty acids and body weight change

Author

Jakobsen, Marianne U, Dethlefsen, Claus, Due, Karen M, Slimani, Nadia, Chajès, Veronique, May, Anne M, Sørensen, Thorkild I A, Halkjær, Jytte, Tjønneland, Anne, Clavel-Chapelon, Francoise, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, Teucher, Birgit, Kaaks, Rudolf, Boeing, Heiner, Schütze, Madlen, Trichopoulou, Antonia, Zylis, Dimosthenis, Makrygiannis, George, Palli, Domenico, Mattiello, Amalia, Tagliabue, Giovanna, van der A, Daphne L, Bueno-de-Mesquita, H B, Rodríguez, Laudina, Travier, Noémie, Molina-Montes, Esther, Huerta, José M, Barricarte, Aurelio, Amiano, Pilar, Manjer, Jonas, Wirfält, Elisabet, Johansson, Ingegerd, Hallmans, Göran, Khaw, Kay-Tee, Wareham, Nicholas J, Crowe, Francesca, Romieu, Isabelle, Riboli, Elio, Peeters, Petra H M, Overvad, Kim, Jakobsen, Marianne U, Dethlefsen, Claus, Due, Karen M, Slimani, Nadia, Chajès, Veronique, May, Anne M, Sørensen, Thorkild I A, Halkjær, Jytte, Tjønneland, Anne, Clavel-Chapelon, Francoise, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, Teucher, Birgit, Kaaks, Rudolf, Boeing, Heiner, Schütze, Madlen, Trichopoulou, Antonia, Zylis, Dimosthenis, Makrygiannis, George, Palli, Domenico, Mattiello, Amalia, Tagliabue, Giovanna, van der A, Daphne L, Bueno-de-Mesquita, H B, Rodríguez, Laudina, Travier, Noémie, Molina-Montes, Esther, Huerta, José M, Barricarte, Aurelio, Amiano, Pilar, Manjer, Jonas, Wirfält, Elisabet, Johansson, Ingegerd, Hallmans, Göran, Khaw, Kay-Tee, Wareham, Nicholas J, Crowe, Francesca, Romieu, Isabelle, Riboli, Elio, Peeters, Petra H M, and Overvad, Kim

Abstract

OBJECTIVE: We investigated the association between the proportion of long-chain n-3 polyunsaturated fatty acids (PUFA) in plasma phospholipids from blood samples drawn at enrollment and subsequent change in body weight. Sex, age, and BMI were considered as potential effect modifiers. METHOD: A total of 1,998 women and men participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) were followed for a median of 4.9 years. The associations between the proportion of plasma phospholipid long-chain n-3 PUFA and change in weight were investigated using mixed-effect linear regression. RESULTS: The proportion of long-chain n-3 PUFA was not associated with change in weight. Among all participants, the 1-year weight change was -0.7 g per 1% point higher long-chain n-3 PUFA level (95% confidence interval: -20.7 to 19.3). The results when stratified by sex, age, or BMI groups were not systematically different. CONCLUSION: The results of this study suggest that the proportion of long-chain n-3 PUFA in plasma phospholipids is not associated with subsequent change in body weight within the range of exposure in the general population.

Published
2011
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46. Plasma phospholipid long-chain n-3 polyunsaturated fatty acids and body weight change

Author

Jakobsen, Marianne Uhre, Dethlefsen, Claus, Due, Karen Margrete, Slimani, Nadia, Chajès, Veronique, May, Anne M, Sørensen, Thorkild I A, Halkjær, Jytte, Tjønneland, Anne, Clavel-Chapelon, Francoise, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, Teucher, Birgit, Kaaks, Rudolf, Boeing, Heiner, Schütze, Madlen, Trichopoulou, Antonia, Zylis, Dimosthenis, Makrygiannis, George, Palli, Domenico, Mattiello, Amalia, Tagliabue, Giovanna, van der, Daphne L, Bueno-de-Mesquita, H B, Rodríguez, Laudina, Travier, Noémie, Molina-Montes, Esther, Huerta, José M, Barricarte, Aurelio, Amiano, Pilar, Manjer, Jonas, Wirfält, Elisabet, Johansson, Ingegerd, Hallmans, Göran, Khaw, Kay-Tee, Wareham, Nicholas J, Crowe, Francesca, Romieu, Isabelle, Riboli, Elio, Peeters, Petra H M, Overvad, Kim, Jakobsen, Marianne Uhre, Dethlefsen, Claus, Due, Karen Margrete, Slimani, Nadia, Chajès, Veronique, May, Anne M, Sørensen, Thorkild I A, Halkjær, Jytte, Tjønneland, Anne, Clavel-Chapelon, Francoise, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, Teucher, Birgit, Kaaks, Rudolf, Boeing, Heiner, Schütze, Madlen, Trichopoulou, Antonia, Zylis, Dimosthenis, Makrygiannis, George, Palli, Domenico, Mattiello, Amalia, Tagliabue, Giovanna, van der, Daphne L, Bueno-de-Mesquita, H B, Rodríguez, Laudina, Travier, Noémie, Molina-Montes, Esther, Huerta, José M, Barricarte, Aurelio, Amiano, Pilar, Manjer, Jonas, Wirfält, Elisabet, Johansson, Ingegerd, Hallmans, Göran, Khaw, Kay-Tee, Wareham, Nicholas J, Crowe, Francesca, Romieu, Isabelle, Riboli, Elio, Peeters, Petra H M, and Overvad, Kim

Abstract

We investigated the association between the proportion of long-chain n-3 polyunsaturated fatty acids (PUFA) in plasma phospholipids from blood samples drawn at enrollment and subsequent change in body weight. Sex, age, and BMI were considered as potential effect modifiers.

Published
2011

47. Obesity, inflammatory markers, and endometrial cancer risk : a prospective case-control study

Author

Dossus, Laure, Rinaldi, Sabina, Becker, Susen, Lukanova, Annekatrin, Tjonneland, Anne, Olsen, Anja, Stegger, Jakob, Overvad, Kim, Chabbert-Buffet, Nathalie, Jimenez-Corona, Aida, Clavel-Chapelon, Francoise, Rohrmann, Sabine, Teucher, Birgit, Boeing, Heiner, Schütze, Madlen, Trichopoulou, Antonia, Benetou, Vassiliki, Lagiou, Pagona, Palli, Domenico, Berrino, Franco, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Redondo, Maria-Luisa, Travier, Noémie, Sanchez, Maria-Jose, Altzibar, Jone M, Chirlaque, Maria-Dolores, Ardanaz, Eva, Bueno-de-Mesquita, H Bas, van Duijnhoven, Fränzel J B, Onland-Moret, N Charlotte, Peeters, Petra H M, Hallmans, Göran, Lundin, Eva, Khaw, Kay-Tee, Wareham, Nicholas, Allen, Naomi, Key, Tim J, Slimani, Nadia, Hainaut, Pierre, Romaguera, Dora, Norat, Teresa, Riboli, Elio, Kaaks, Rudolf, Dossus, Laure, Rinaldi, Sabina, Becker, Susen, Lukanova, Annekatrin, Tjonneland, Anne, Olsen, Anja, Stegger, Jakob, Overvad, Kim, Chabbert-Buffet, Nathalie, Jimenez-Corona, Aida, Clavel-Chapelon, Francoise, Rohrmann, Sabine, Teucher, Birgit, Boeing, Heiner, Schütze, Madlen, Trichopoulou, Antonia, Benetou, Vassiliki, Lagiou, Pagona, Palli, Domenico, Berrino, Franco, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Redondo, Maria-Luisa, Travier, Noémie, Sanchez, Maria-Jose, Altzibar, Jone M, Chirlaque, Maria-Dolores, Ardanaz, Eva, Bueno-de-Mesquita, H Bas, van Duijnhoven, Fränzel J B, Onland-Moret, N Charlotte, Peeters, Petra H M, Hallmans, Göran, Lundin, Eva, Khaw, Kay-Tee, Wareham, Nicholas, Allen, Naomi, Key, Tim J, Slimani, Nadia, Hainaut, Pierre, Romaguera, Dora, Norat, Teresa, Riboli, Elio, and Kaaks, Rudolf

Abstract

Obesity, a major risk factor for endometrial cancer, is a low-grade inflammatory state characterized by elevated concentrations of cytokines and acute phase reactants. The current study had two aims: first to investigate the associations of C-reactive protein (CRP), interleukin 6 (IL6), and IL1 receptor antagonist (IL1Ra) with endometrial cancer risk and second to examine to which extent these markers can influence the association between obesity and endometrial cancer. We conducted a case-control study, nested within the European Prospective Investigation into Cancer and Nutrition, which comprised 305 incident cases of endometrial cancer and 574 matched controls. CRP, IL6, and IL1Ra were measured in prospectively collected blood specimens by immunoassays. Data were analyzed using conditional logistic regression. All statistical tests were two-sided, and P values <0.05 were considered statistically significant. We observed a significant increase in risk of endometrial cancer with elevated levels of CRP (odds ratio (OR) for top versus bottom quartile: 1.58, 95% confidence interval (CI): 1.03-2.41, P(trend)=0.02), IL6 (OR for top versus bottom quartile: 1.66, 95% CI: 1.08-2.54, P(trend)=0.008), and IL1Ra (OR for top versus bottom quartile: 1.82, 95% CI: 1.22-2.73, P(trend)=0.004). After adjustment for body mass index (BMI), the estimates were strongly reduced and became non-significant. The association between BMI and endometrial cancer was also substantially attenuated (∼10-20%) after adjustment for inflammatory markers, even when the effects of C-peptide or estrone had already been taken into account. We provided epidemiological evidence that chronic inflammation might mediate the association between obesity and endometrial cancer and that endometrial carcinogenesis could be promoted by an inflammatory milieu.

Published
2010
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48. Menstrual and reproductive factors, exogenous hormone use, and gastric cancer risk in a cohort of women from the European Prospective Investigation Into Cancer and Nutrition

Author

Duell, Eric J, Travier, Noémie, Lujan-Barroso, Leila, Boutron-Ruault, MC, Clavel-Chapelon, F, Palli, Domenico, Krogh, Vittorio, Mattiello, Amalia, Tumino, Rosario, Sacerdote, Carlotta, Rodriguez, Laudina, Sanchez-Cantalejo, Emilio, Navarro, Carmen, Barricarte, Aurelio, Dorronsoro, Miren, Khaw, Kay-Tee, Wareham, Nicholas, Allen, Naomi E, Tsilidis, Konstantinos K, Bueno-de-Mesquita, H Bas, Jeurnink, Suzanne M, Numans, ME, Peeters, Petra HM, Lagiou, Pagona, Valanou, Elisabeth, Trichopoulou, Antonia, Kaaks, Rudolf, Lukanova-McGregor, Annekatrin, Bergman, Manuela M, Boeing, Heiner, Manjer, Jonas, Lindkvist, Björn, Stenling, Roger, Hallmans, Göran, Dahm, Christina C, Overvad, Kim, Olsen, Anja, Tjonneland, Anne, Bakken, Kjersti, Lund, Eiliv, Jenab, Mazda, McCormack, Valerie, Rinaldi, Sabina, Michaud, Dominique, Mouw, Traci, Nesi, Gabriella, Carneiro, Fatima, Riboli, Elio, González, Carlos A, Duell, Eric J, Travier, Noémie, Lujan-Barroso, Leila, Boutron-Ruault, MC, Clavel-Chapelon, F, Palli, Domenico, Krogh, Vittorio, Mattiello, Amalia, Tumino, Rosario, Sacerdote, Carlotta, Rodriguez, Laudina, Sanchez-Cantalejo, Emilio, Navarro, Carmen, Barricarte, Aurelio, Dorronsoro, Miren, Khaw, Kay-Tee, Wareham, Nicholas, Allen, Naomi E, Tsilidis, Konstantinos K, Bueno-de-Mesquita, H Bas, Jeurnink, Suzanne M, Numans, ME, Peeters, Petra HM, Lagiou, Pagona, Valanou, Elisabeth, Trichopoulou, Antonia, Kaaks, Rudolf, Lukanova-McGregor, Annekatrin, Bergman, Manuela M, Boeing, Heiner, Manjer, Jonas, Lindkvist, Björn, Stenling, Roger, Hallmans, Göran, Dahm, Christina C, Overvad, Kim, Olsen, Anja, Tjonneland, Anne, Bakken, Kjersti, Lund, Eiliv, Jenab, Mazda, McCormack, Valerie, Rinaldi, Sabina, Michaud, Dominique, Mouw, Traci, Nesi, Gabriella, Carneiro, Fatima, Riboli, Elio, and González, Carlos A

Abstract

The worldwide incidence of gastric adenocarcinoma (GC) is lower in women than in men. Furthermore, cancer patients treated with estrogens have been reported to have a lower subsequent risk of GC. The authors conducted a prospective analysis of menstrual and reproductive factors, exogenous hormone use, and GC in 335,216 women from the European Prospective Investigation Into Cancer and Nutrition, a cohort study of individuals aged 35-70 years from 10 European countries. After a mean follow-up of 8.7 years (through 2004), 181 women for whom complete exposure data were available developed GC. Adjusted hazard ratios and 95% confidence intervals were estimated using Cox proportional hazards models. All statistical tests were 2-sided. Women who had ovariectomy had a 79% increased risk of GC (based on 25 cases) compared with women who did not (hazard ratio = 1.79, 95% confidence interval: 1.15, 2.78). Total cumulative years of menstrual cycling was inversely associated with GC risk (fifth vs. first quintile: hazard ratio = 0.55, 95% confidence interval: 0.31, 0.98; P(trend) = 0.06). No other reproductive factors analyzed were associated with risk of GC. The results of this analysis provide some support for the hypothesis that endogenous ovarian sex hormones lower GC incidence in women.

Published
2010
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49. Smoking and body fatness measurements : a cross-sectional analysis in the EPIC-PANACEA study

Author

Travier, Noémie, Agudo, Antonio, May, Anne M, Gonzalez, Carlos, Luan, Jian'an, Besson, Hervé, Wareham, Nick J, Slimani, Nadia, Rinaldi, Sabina, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Palli, Domenico, Agnoli, Claudia, Mattiello, Amalia, Tumino, Rosario, Vineis, Paolo, Rodriguez, Laudina, Sanchez, Maria-José, Dorronsoro, Miren, Barricarte, Aurelio, Tormo, Maria-José, Norat, Teresa, Mouw, Traci, Key, Tim J, Spencer, Elizabeth A, Bueno-de-Mesquita, H Bas, Vrieling, Alina, Orfanos, Philippos, Naska, Ada, Trichopoulou, Antonia, Rohrmann, Sabina, Kaaks, Rudolf, M Bergmann, Manuela, Boeing, Heiner, Hallmans, Goran, Johansson, Ingegerd, Manjer, Jonas, Lindkvist, Björn, Jakobsen, Mariane Uhre, Overvad, Kim, Tjonneland, Anne, Halkjaer, Jytte, Lund, Eiliv, Braaten, Toni, Odysseos, Andreani, Riboli, Elio, Peeters, Petra H, Travier, Noémie, Agudo, Antonio, May, Anne M, Gonzalez, Carlos, Luan, Jian'an, Besson, Hervé, Wareham, Nick J, Slimani, Nadia, Rinaldi, Sabina, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Palli, Domenico, Agnoli, Claudia, Mattiello, Amalia, Tumino, Rosario, Vineis, Paolo, Rodriguez, Laudina, Sanchez, Maria-José, Dorronsoro, Miren, Barricarte, Aurelio, Tormo, Maria-José, Norat, Teresa, Mouw, Traci, Key, Tim J, Spencer, Elizabeth A, Bueno-de-Mesquita, H Bas, Vrieling, Alina, Orfanos, Philippos, Naska, Ada, Trichopoulou, Antonia, Rohrmann, Sabina, Kaaks, Rudolf, M Bergmann, Manuela, Boeing, Heiner, Hallmans, Goran, Johansson, Ingegerd, Manjer, Jonas, Lindkvist, Björn, Jakobsen, Mariane Uhre, Overvad, Kim, Tjonneland, Anne, Halkjaer, Jytte, Lund, Eiliv, Braaten, Toni, Odysseos, Andreani, Riboli, Elio, and Peeters, Petra H

Abstract

Objective: The present study investigates the cross-sectional relationship between tobacco smoking and body fatness. Methods: This cross-sectional study consisted of 469,543 men and women who participated in the European Prospective Investigation into Cancer and Nutrition (EPIC) study between 1992 and 2000 providing anthropometric measurements and information on smoking. Adjusted multilevel mixed-effects linear regression models were used to assess the association between smoking and body fat mass. Results: The analyses showed that BMI and WC were positively associated with smoking intensity in current smokers but negatively associated with time since quitting in former smokers. When compared to never smokers, average current smokers (17 and 13 cig/day for men and women, respectively) showed a lower BMI. When average former smokers (men and women who had stopped smoking for 16 and 15 years, respectively) were compared to never smokers, higher BMI and WC were observed in men, whereas no significant associations were observed in women. Conclusions: This cross-sectional study suggests that smoking may be associated with body fatness and fat distribution. Although our findings cannot establish cause and effect, they suggest that providing information and support to those who want to stop may help in preventing weight gain and therefore weaken a barrier against stopping smoking.

Published
2009
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50. Metabolic syndrome, plasma lipid, lipoprotein and glucose levels, and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC).

Author

Cust, Anne E, Kaaks, Rudolf, Friedenreich, Christine, Bonnet, Fabrice, Laville, Martine, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Jakobsen, Marianne Uhre, Chajès, Véronique, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Linseisen, Jakob, Lukanova, Annekatrin, Boeing, Heiner, Pischon, Tobias, Trichopoulou, Antonia, Christina, Bamia, Trichopoulos, Dimitrios, Palli, Domenico, Berrino, Franco, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Gram, Inger Torhild, Lund, Eiliv, Quirós, J R, Travier, Noémie, Martínez-García, Carmen, Larrañaga, Nerea, Chirlaque, María-Dolores, Ardanaz, Eva, Berglund, Göran, Lundin, Eva, Bueno-de-Mesquita, H Bas, van Duijnhoven, Fränzel J B, Peeters, Petra H M, Bingham, Sheila, Khaw, Kay-Tee, Allen, Naomi, Key, Tim, Ferrari, Pietro, Rinaldi, Sabina, Slimani, Nadia, Riboli, Elio, Cust, Anne E, Kaaks, Rudolf, Friedenreich, Christine, Bonnet, Fabrice, Laville, Martine, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Jakobsen, Marianne Uhre, Chajès, Véronique, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Linseisen, Jakob, Lukanova, Annekatrin, Boeing, Heiner, Pischon, Tobias, Trichopoulou, Antonia, Christina, Bamia, Trichopoulos, Dimitrios, Palli, Domenico, Berrino, Franco, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Gram, Inger Torhild, Lund, Eiliv, Quirós, J R, Travier, Noémie, Martínez-García, Carmen, Larrañaga, Nerea, Chirlaque, María-Dolores, Ardanaz, Eva, Berglund, Göran, Lundin, Eva, Bueno-de-Mesquita, H Bas, van Duijnhoven, Fränzel J B, Peeters, Petra H M, Bingham, Sheila, Khaw, Kay-Tee, Allen, Naomi, Key, Tim, Ferrari, Pietro, Rinaldi, Sabina, Slimani, Nadia, and Riboli, Elio

Published
2007

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