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5. Quality of life, hearing results, patient satisfaction and postoperative complications of day-case versus inpatient unilateral cochlear implantation in adults: a randomized controlled, equivalence trial

Author

Zorgeenheid KNO Medisch, MS KNO, Brain, Other research (not in main researchprogram), Bijzondere Formatie, MS Hoofd-Hals Chirurgische Oncologie, Derks, Laura S.M., Smit, Adriana L., Thomeer, Hans G.X.M., Topsakal, Vedat, Grolman, Wilko, Stokroos, Robert J., Wegner, Inge, Zorgeenheid KNO Medisch, MS KNO, Brain, Other research (not in main researchprogram), Bijzondere Formatie, MS Hoofd-Hals Chirurgische Oncologie, Derks, Laura S.M., Smit, Adriana L., Thomeer, Hans G.X.M., Topsakal, Vedat, Grolman, Wilko, Stokroos, Robert J., and Wegner, Inge

Published
2024

12. Risk Factors for Postoperative Neck Complaints After Robot-Assisted Surgery. A Systematic Literature Review

Author

Rommers, Ellis, Jacxsens, Laura, Van Brussel, Naomi, Topsakal, Vedat, and De Hertogh, Willem

Subjects
Human medicine
Abstract

Background: Robot-assisted and image-guided surgery have become increasingly important because it outperforms human dexterity. For procedures on sub-millimet-ric level, fixing the patient’s head firmly is crucial. Although the neck is not the targetorgan of the operation, it may be at risk of postoperative complaints due to position-ing or fixation. The incidence of postoperative symptoms after head and neck surgery with fixation is hardly reported and probably underestimated, in regards to the life-threatening cranial pathologies for which the surgery was required. Methods: To identify papers on risk factors for postoperative complaints after headand neck surgery, we performed a systematic review. PubMed and Web of Sciencedatabases were searched using predefined in- and exclusion criteria. Meta-analysesand reviews were excluded. Postoperative complaints concerned pain, quality oflife, discomfort, neuropraxia, and musculoskeletal problems. This review is reportedaccording to PRISMA guidelines. Results: Seven eligible studies were identified, only 2 concerned surgery requiring head fixation. The significant risk factors resulting from our analysis were preopera- tive pain (odds ratio=2.19), expected pain (odds ratio=2.15), short-term fear (odds ratio = 1.42), age between 45 and 59 years old (odds ratio = 1.40), pain catastrophizing (odds ratio = 1.21), and female gender (odds ratio = 0.74). Conclusion: Six significant risk factors for iatrogenic postoperative complaints after head and neck surgery have been identified. These risk factors should be consideredas possible confounding factors in future research. Little literature could be found. Upcoming robotic surgeries in the head and neck area pose a clinical need for morespecific studies on postoperative iatrogenic complaints.

Published
2022
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16. Anatomical barriers against SARS-CoV-2 neuroinvasion at vulnerable interfaces visualized in deceased COVID-19 patients

Author

Khan, Mona, primary, Clijsters, Marnick, additional, Choi, Sumin, additional, Backaert, Wout, additional, Claerhout, Michiel, additional, Couvreur, Floor, additional, Van Breda, Laure, additional, Bourgeois, Florence, additional, Speleman, Kato, additional, Klein, Sam, additional, Van Laethem, Johan, additional, Verstappen, Gill, additional, Dereli, Ayse Sumeyra, additional, Yoo, Seung-Jun, additional, Zhou, Hai, additional, Dan Do, Thuc Nguyen, additional, Jochmans, Dirk, additional, Laenen, Lies, additional, Debaveye, Yves, additional, De Munter, Paul, additional, Gunst, Jan, additional, Jorissen, Mark, additional, Lagrou, Katrien, additional, Meersseman, Philippe, additional, Neyts, Johan, additional, Thal, Dietmar Rudolf, additional, Topsakal, Vedat, additional, Vandenbriele, Christophe, additional, Wauters, Joost, additional, Mombaerts, Peter, additional, and Van Gerven, Laura, additional

Published
2022
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17. Minimally Traumatic Cochlear Implant Surgery: Expert Opinion in 2010 and 2020

Author

Topsakal, Vedat, primary, Agrawal, Sumit, additional, Atlas, Marcus, additional, Baumgartner, Wolf-Dieter, additional, Brown, Kevin, additional, Bruce, Iain A., additional, Dazert, Stefan, additional, Hagen, Rudolf, additional, Lassaletta, Luis, additional, Mlynski, Robert, additional, Raine, Christopher H., additional, Rajan, Gunesh P., additional, Schmutzhard, Joachim, additional, Sprinzl, Georg Mathias, additional, Staecker, Hinrich, additional, Usami, Shin-ichi, additional, Van Rompaey, Vincent, additional, Zernotti, Mario, additional, and Heyning, Paul van de, additional

Published
2022
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19. Audiometric Findings in Senior Adults of 80 Years and Older

Author

De Raedemaeker, Kaat, primary, Foulon, Ina, additional, Vella Azzopardi, Roberta, additional, Lichtert, Elke, additional, Buyl, Ronald, additional, Topsakal, Vedat, additional, Beyer, Ingo, additional, Bautmans, Ivan, additional, Michel, Olaf, additional, and Gordts, Frans, additional

Published
2022
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20. Systematic Literature Review of Hearing Preservation Rates in Cochlear Implantation Associated With Medium- and Longer-Length Flexible Lateral Wall Electrode Arrays

Author

Van de Heyning, Paul H, primary, Dazert, Stefan, additional, Gavilan, Javier, additional, Lassaletta, Luis, additional, Lorens, Artur, additional, Rajan, Gunesh P, additional, Skarzynski, Henryk, additional, Skarzynski, Piotr H, additional, Tavora-Vieira, Dayse, additional, Topsakal, Vedat, additional, Usami, Shin-ichi, additional, Van Rompaey, Vincent, additional, Weiss, Nora M, additional, and Polak, Marek, additional

Published
2022
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21. Ability to Drive in Patients with Dizziness: The Belgian Perspective

Author

UCL - (SLuc) Service d'oto-rhino-laryngologie, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Centre labio-palatin Albert de Coninck, Van Rompaey, Vincent, Somers, Thomas, Deggouj, Naima, de Varebeke, Sebastien Janssens, Lefebvre, Philippe, Topsakal, Vedat, UCL - (SLuc) Service d'oto-rhino-laryngologie, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Centre labio-palatin Albert de Coninck, Van Rompaey, Vincent, Somers, Thomas, Deggouj, Naima, de Varebeke, Sebastien Janssens, Lefebvre, Philippe, and Topsakal, Vedat

Abstract

Dizziness is one of the most frequent complaints of patients and up to 20% consult physicians for it every year. Patients can suffer from dif- ferent types of symptoms, including spontaneous vertigo spells, head-movement-induced vertigo spells and chronic dizziness. All of these symptoms are highly relevant while driving and may put the patient and their surroundings in significant danger. This paper highlights the impact of aspects relevant to the dizzy patient on driving ability (incl. the impact of medication and surgery).

Published
2022

22. Suitable Electrode Choice for Robotic-Assisted Cochlear Implant Surgery: A Systematic Literature Review of Manual Electrode Insertion Adverse Events

Author

Van de Heyning, Paul, primary, Roland, Peter, additional, Lassaletta, Luis, additional, Agrawal, Sumit, additional, Atlas, Marcus, additional, Baumgartner, Wolf-Dieter, additional, Brown, Kevin, additional, Caversaccio, Marco, additional, Dazert, Stefan, additional, Gstoettner, Wolfgang, additional, Hagen, Rudolf, additional, Hagr, Abdulrahman, additional, Jablonski, Greg Eigner, additional, Kameswaran, Mohan, additional, Kuzovkov, Vladislav, additional, Leinung, Martin, additional, Li, Yongxin, additional, Loth, Andreas, additional, Magele, Astrid, additional, Mlynski, Robert, additional, Mueller, Joachim, additional, Parnes, Lorne, additional, Radeloff, Andreas, additional, Raine, Chris, additional, Rajan, Gunesh, additional, Schmutzhard, Joachim, additional, Skarzynski, Henryk, additional, Skarzynski, Piotr H., additional, Sprinzl, Georg, additional, Staecker, Hinrich, additional, Stöver, Timo, additional, Tavora-Viera, Dayse, additional, Topsakal, Vedat, additional, Usami, Shin-Ichi, additional, Van Rompaey, Vincent, additional, Weiss, Nora M., additional, Wimmer, Wilhelm, additional, Zernotti, Mario, additional, and Gavilan, Javier, additional

Published
2022
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24. Ability to Drive in Patients with Dizziness: The Belgian Perspective

Author

Van Rompaey, Vincent, Somers, Thomas, Deggouj, Naima, Janssens de Varebeke, Sebastien, Lefebvre, Philippe, Topsakal, Vedat, UCL - (SLuc) Service d'oto-rhino-laryngologie, UCL - SSS/IONS/NEUR - Clinical Neuroscience, and UCL - (SLuc) Centre labio-palatin Albert de Coninck

Subjects
Human medicine
Abstract

Dizziness is one of the most frequent complaints of patients and up to 20% consult physicians for it every year. Patients can suffer from different types of symptoms, including spontaneous vertigo spells, head-movement-induced vertigo spells and chronic dizziness. All of these symptoms are highly relevant while driving and may put the patient and their surroundings in significant danger. This paper highlights the impact of aspects relevant to the dizzy patient on driving ability (incl. the impact of medication and surgery).

Published
2022

26. Cognitive Improvement After Cochlear Implantation in Older Adults With Severe or Profound Hearing Impairment: A Prospective, Longitudinal, Controlled, Multicenter Study

Author

Mertens, Griet, Andries, Ellen, Claes, Annes J., Topsakal, Vedat, Van de Heyning, Paul, Van Rompaey, Vincent, Calvino, Miryam, Sanchez Cuadrado, Isabel, Bie?kowska, Katarzyna, wierniak, Weronika, Skar?y?ski, Piotr Henryk, Skar?y?ski, Henryk, Tapper, Lynne, Killan, Catherine, Ridgwell, Jillian, McGowan, Janet, Raine, Christopher, Tavora-Vieira, Dayse, Marino, Roberta, Acharya, Aanand, and Lassaletta, Luis

Subjects
Speech and Hearing, Otorhinolaryngology, otorhinolaryngologic diseases
Abstract

Objective: To compare the cognitive evolution of older adults with severe or profound hearing impairment after cochlear implantation with that of a matched group of older adults with severe hearing impairment who do not receive a cochlear implant (CI).Design: In this prospective, longitudinal, controlled, and multicenter study, 24 older CI users were included in the intervention group and 24 adults without a CI in the control group. The control group matched the intervention group in terms of gender, age, formal education, cognitive functioning, and residual hearing. Assessments were made at baseline and 14 months later. Primary outcome measurements included the change in the total score on the Repeatable Battery for the Assessment of Neuropsychological Status for Hearing impaired individuals score and on its subdomain score to assess cognitive evolution in both groups. Secondary outcome measurements included self-reported changes in sound quality (Hearing Implant Sound Quality Index), self-perceived hearing disability (Speech, Spatial, and Qualities of Hearing Scale), states of anxiety and depression (Hospital Anxiety and Depression Scale), and level of negative affectivity and social inhibition (Type D questionnaire).Results: Improvements of the overall cognitive functioning (p = 0.05) and the subdomain “Attention” (p = 0.02) were observed after cochlear implantation in the intervention group; their scores were compared to the corresponding scores in the control group. Significant positive effects of cochlear implantation on sound quality and self-perceived hearing outcomes were found in the intervention group. Notably, 20% fewer traits of Type D personalities were measured in the intervention group after cochlear implantation. In the control group, traits of Type D personalities increased by 13%.Conclusion: Intervention with a CI improved cognitive functioning (domain Attention in particular) in older adults with severe hearing impairment compared to that of the matched controls with hearing impairment without a CI. However, older CI users did not, in terms of cognition, bridge the performance gap with adults with normal hearing after 1 year of CI use. The fact that experienced, older CI users still present subnormal cognitive functioning may highlight the need for additional cognitive rehabilitation in the long term after implantation.

Published
2021

27. A wide range of protective and predisposing variants in aggrecan influence the susceptibility for otosclerosis

Author

Højland, Allan Thomas, primary, Tavernier, Lisse J. M., additional, Schrauwen, Isabelle, additional, Sommen, Manou, additional, Topsakal, Vedat, additional, Schatteman, Isabelle, additional, Dhooge, Ingeborg, additional, Huber, Alex, additional, Zanetti, Diego, additional, Kunst, Henricus P. M., additional, Hoischen, Alexander, additional, Petersen, Michael B., additional, Van Camp, Guy, additional, and Fransen, Erik, additional

Published
2021
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28. Global research on hereditary hearing impairment over the last 40 years: A bibliometric study

Author

Tekin, Ahmet Mahmut, Bahşi, İlhan, Bayazıt, Yıldırım Ahmet, and Topsakal, Vedat

Subjects
Databases, Factual, Publications, Deafness, United States, Hereditary, Hereditary Hearing Loss, Otorhinolaryngology, RF1-547, Bibliometrics, Bibliometric Analysis, otorhinolaryngologic diseases, Humans, Publication, Genetic Deafness, Hearing Loss
Abstract

BACKGROUND: Research on hereditary hearing impairment has had several boosts to identify deafness-causing genes. The number of studies regarding the diagnosis and treatment modalities of hereditary hearing impairment is enormous and increasing; however, little or no research has been conducted for evaluating the development of scientific output and trends in the field. Here, we provide a comprehensive overview of centers that focus their research on hereditary hearing impairment and their scientific output. METHODS: Bibliometric analysis of the publications related to hereditary hearing impairment published between 1980 and 2019 were used in this study, which were also indexed in Web of Science database. RESULTS: The highest number of scientific articles on hereditary hearing impairment came from the United States, and it was also the most cited country. The University of Iowa is a leading center in the domain of hereditary hearing impairment in the world over the last 40 years. Fudan University, Central South University, and Harvard Medical School are also institutions that have had a focus on hereditary hearing impairment. CONCLUSIONS: There is a progressive increase in scientific papers on hereditary hearing impairment over the last 40 years that we have found in our bibliometric study. We identified key centers in the scientific research on hereditary hearing impairment in the world and also key journals that focus on hereditary hearing impairment. This information can facilitate new researchers in this field to seek collaboration with experienced partners, better synthesize the orientation and boundaries of the subject, and find target journals. Ultimately, we provided a certain benchmark value for key centers that perhaps should have a more prominent role in constructing experimental research or even clinical guidelines.

Published
2021

29. Occupational Noise, Smoking, and a High Body Mass Index are Risk Factors for Age-related Hearing Impairment and Moderate Alcohol Consumption is Protective: A European Population-based Multicenter Study

Author

Fransen, Erik, Topsakal, Vedat, Hendrickx, Jan-Jaap, Van Laer, Lut, Huyghe, Jeroen R., Van Eyken, Els, Lemkens, Nele, Hannula, Samuli, Mäki-Torkko, Elina, Jensen, Mona, Demeester, Kelly, Tropitzsch, Anke, Bonaconsa, Amanda, Mazzoli, Manuela, Espeso, Angeles, Verbruggen, Katia, Huyghe, Joke, Huygen, Patrick L. M., Kunst, Sylvia, Manninen, Minna, Diaz-Lacava, Amalia, Steffens, Michael, Wienker, Thomas F., Pyykkö, Ilmari, Cremers, Cor W. R. J., Kremer, Hannie, Dhooge, Ingeborg, Stephens, Dafydd, Orzan, Eva, Pfister, Markus, Bille, Michael, Parving, Agnete, Sorri, Martti, Van de Heyning, Paul, and Van Camp, Guy

Published
2008
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31. Case-Control Microbiome Study of Chronic Otitis Media with Effusion in Children Points at Streptococcus salivarius as a Pathobiont-Inhibiting Species

Author

Jörissen, Jennifer, primary, van den Broek, Marianne F. L., additional, De Boeck, Ilke, additional, Van Beeck, Wannes, additional, Wittouck, Stijn, additional, Boudewyns, An, additional, Van de Heyning, Paul, additional, Topsakal, Vedat, additional, Van Rompaey, Vincent, additional, Wouters, Ine, additional, Van Heirstraeten, Liesbet, additional, Van Damme, Pierre, additional, Malhotra-Kumar, Surbi, additional, Theeten, Heidi, additional, Vanderveken, Olivier M., additional, and Lebeer, Sarah, additional

Published
2021
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33. Genome-wide SNP-based linkage scan identifies a locus on 8q24 for an age-related hearing impairment trait

Author

Huyghe, Jeroen R., Demeester, Kelly, Van Camp, Guy, Pfister, Markus, Nurnberg, Peter, Van Laer, Lut, Hendrickx, Jan-Jaap, Fransen, Erikz, Topsakal, Vedat, Bonaconsa, Wienker, Thomas F., Van de Heyning, Paul H., Kunst, Sylvia, Manninen, Minna, Jensen, Mona, Mazzoli, Manuela, Baur, Manuela, Hannula, Samuli, Maki-Torkko, Elina, Espeso, Angeles, Van Eyken, Els, Flaquer, Antonia, Becker, Christian, Stephens, Dafydd, Sorri, Martti, Orzan, Eva, Bille, Michael, Parving, Agnete, Pyykko, Ilmari, Cremers, Cor W.R.J., and Kremer, Hannie

Subjects
Linkage (Genetics) -- Analysis, Human genetics -- Analysis, Single nucleotide polymorphisms -- Analysis, Biological sciences
Abstract

A genome-wide association and a linkage scan based on high-density SNP microarrays are conducted for the identification of a locus on 8q24, which is shown to lead to the age-related hearing impairment (ARHI) in humans. Genetics is also shown to play an extremely significant role in the etiology of ARHI.

Published
2008

34. DFNA9 : de meest voorkomende erfelijke vorm van progressief gehoorverlies en evenwichtsuitval op volwassen leeftijd in de Lage Landen

Author

Janssens de Varebeke, Sebastien, Van Camp, Guy, Van de Heyning, Paul, Topsakal, Vedat, and Van Rompaey, Vincent

Subjects
Human medicine
Abstract

DFNA9 is een ziektebeeld dat in de Lage Landen vooral wordt veroorzaakt door de p.P51S-mutatie in het COCH-gen, met een laattijdige aanvang (ongeveer het vierde levensdecennium) van het gehoorverlies én de evenwichtsstoornissen, die binnen een periode van enkele decennia evolueren naar beiderzijdse uitval. Een aantal patiënten kunnen in de beginfase een Ménière-achtig ziektebeeld vertonen onder de vorm van fluctuerend gehoorverlies, druksensaties en aanvallen van duizeligheid. Zowel het gehoor als het evenwicht takelen het snelst af tijdens het vijfde levensdecennium. De exacte aanvang van de evenwichtsstoornissen is minder goed omschreven omdat er weinig presymptomatische dragers werden onderzocht en omdat de vestibulaire symptomen in het begin discreter zijn of sterk kunnen verschillen per individu. Recente studies toonden aan dat bijna de helft van de gehoorgestoorde patiënten hun gehoorprobleem voor het eerst bespreekt met de huisarts, die daarom een belangrijke rol speelt in de aanpak ervan. Bij volwassenen met progressief gehoorverlies en/of een Ménière-achtig ziektebeeld én die een positieve familiale anamnese hebben voor gehoor- en/of evenwichtsproblemen, moet DFNA9 toegevoegd worden aan de differentiaaldiagnose. Dit artikel geeft een overzicht van de nieuwe inzichten in de verschillende mutaties in het COCH-gen, de pathogenese, de verschillende ziektebeelden tussen de mutaties die voorkomen in de Lage Landen, de recente nieuwe radiologische bevindingen bij DFNA9 en de toekomstperspectieven.

Published
2020

35. Evaluation of Artificial Fixation of the Incus and Malleus With Minimally Invasive Intraoperative Laser Vibrometry (MIVIB) in a Temporal Bone Model

Author

Gladine, Kilian, Wales, Jeremy, Silvola, Juha, Muyshondt, Pieter G. G., Topsakal, Vedat, De Heyning, Paul Van, Dirckx, Joris J. J., von Unge, Magnus, Gladine, Kilian, Wales, Jeremy, Silvola, Juha, Muyshondt, Pieter G. G., Topsakal, Vedat, De Heyning, Paul Van, Dirckx, Joris J. J., and von Unge, Magnus

Abstract

Background: A significant number of adults suffer from conductive hearing loss due to chronic otitis media, otosclerosis, or other pathologies. An objective measurement of ossicular mobility is needed to avoid unnecessarily invasive middle ear surgery and to improve hearing outcomes. Methods: Minimally invasive intraoperative laser vibrometry provides a method that is compatible with middle ear surgery, where the tympanic membrane is elevated. The ossicles were driven by a floating mass transducer and their mobility was measured using a laser Doppler vibrometer. Utilising this method, we assessed both the absolute velocities of the umbo and incus long process as well as the incus-to-umbo velocity ratio during artificial fixation of the incus alone or incus and malleus together. Results: The reduction of absolute velocities was 8 dB greater at the umbo and 17 dB at the incus long process for incus-malleus fixations when compared with incus fixation alone. Incus fixation alone resulted in no change to the incus-to-umbo velocity ratio where incus-malleus fixations reduced this ratio (-11 dB). The change in incus velocity was shown to be the most suitable parameter to distinguish between incus fixation and incus-malleus fixation. When the whole frequency range was analyzed, one could also differentiate these two fixations from previously published stapes fixation, where the higher frequencies were less affected. Conclusion: Minimally invasive intraoperative laser vibrometry provides a promising objective analysis of ossicular mobility that would be useful intraoperatively.

Published
2020
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38. Prognostic Indicators for Positive Treatment Outcome After Multidisciplinary Orofacial Treatment in Patients With Somatosensory Tinnitus

Author

van der Wal, Annemarie, primary, Van de Heyning, Paul, additional, Gilles, Annick, additional, Jacquemin, Laure, additional, Topsakal, Vedat, additional, Van Rompaey, Vincent, additional, Braem, Marc, additional, Visscher, Corine Mirjam, additional, Truijen, Steven, additional, Michiels, Sarah, additional, and De Hertogh, Willem, additional

Published
2020
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40. Sex Differences in the Response to Different Tinnitus Treatment

Author

Van der Wal, Annemarie, primary, Luyten, Tine, additional, Cardon, Emilie, additional, Jacquemin, Laure, additional, Vanderveken, Olivier M., additional, Topsakal, Vedat, additional, Van de Heyning, Paul, additional, De Hertogh, Willem, additional, Van Looveren, Nancy, additional, Van Rompaey, Vincent, additional, Michiels, Sarah, additional, and Gilles, Annick, additional

Published
2020
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41. Treatment of Somatosensory Tinnitus: A Randomized Controlled Trial Studying the Effect of Orofacial Treatment as Part of a Multidisciplinary Program

Author

van der Wal, Annemarie, primary, Michiels, Sarah, additional, Van de Heyning, Paul, additional, Braem, Marc, additional, Visscher, Corine M., additional, Topsakal, Vedat, additional, Gilles, Annick, additional, Jacquemin, Laure, additional, Van Rompaey, Vincent, additional, and De Hertogh, Willem, additional

Published
2020
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42. Additional file 1: of Conservative therapy for the treatment of patients with somatic tinnitus attributed to temporomandibular dysfunction: study protocol of a randomised controlled trial

Author

Michiels, Sarah, Wal, Annemarie Van Der, Nieste, Evelien, Heyning, Paul Van De, Braem, Marc, Visscher, Corine, Topsakal, Vedat, Gilles, Annick, Jacquemin, Laure, Hesters, Marianne, and Hertogh, Willem De

Abstract

SPIRIT 2013 Checklist: Recommended items to address in a clinical trial protocol and related documents. (PDF 1226 kb)

Published
2018
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45. Impact of Superior Canal Dehiscence Syndrome on Health Utility Values: A Prospective Case-Control Study.

Author

Ocak, Ibrahim, Topsakal, Vedat, Van de Heyning, Paul, Van Haesendonck, Gilles, Jorissen, Cathérine, van de Berg, Raymond, Vanderveken, Olivier M., and Van Rompaey, Vincent

Subjects
LONGITUDINAL method, CASE-control method, MANN Whitney U Test, SEMICIRCULAR canals, INNER ear
Abstract

Introduction: Superior canal dehiscence syndrome (SCDS) is a condition characterized by a defect in the bone overlying the superior semicircular canal, creating a third mobile window into the inner ear. Patients can experience disabling symptoms and opt for surgical management. Limited data are available on the impact of SCDS on health-related quality of life (HRQoL) and disease-specific HRQoL more specifically. Objective: To perform a prospective analysis on generic HRQoL in SCDS patients compared to healthy age-matched controls. Methods: A prospective study was performed on patients diagnosed with SCDS and who did not undergo reconstructive surgery yet. Patients were recruited between November 2017 and January 2020 and asked to complete the Health Utility Index (HUI) Mark 2 (HUI2)/Mark 3 (HUI3) questionnaire. For the control group, age-matched participants without otovestibular pathology or other chronic pathology were recruited. The multi-attribute utility function (MAUF) score was calculated for the HUI2 and HUI3. Results of both groups were compared using the Mann-Whitney U test. Results: A total of 20 patients completed the questionnaire. Age ranged from 37 to 79 years with a mean age of 56 years (45% males and 55% females). The control group consisted of 20 participants with a mean age of 56.4 years and ranged from 37 to 82 years (35% males and 65% females). For the case group, median HUI2 MAUF score was 0.75 and median HUI3 MAUF score was 0.65. For the control group, the median scores were 0.88 and 0.86 respectively. There was a statistically significant difference for both HUI2 (p = 0.024) and HUI3 (p = 0.011). SCDS patients had a worse generic HRQoL than age-matched healthy controls. One patient with unilateral SCDS had a negative HUI3 MAUF score (−0.07), indicating a health-state worse than death. Conclusion: SCDS patients have significantly lower health utility values than an age-matched control group. This confirms the negative impact of SCDS on generic HRQoL, even when using an instrument that is not designed to be disease-specific but to assess health state in general. These data can be useful to compare impact on HRQoL among diseases. [ABSTRACT FROM AUTHOR]

Published
2020
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46. Comparison of the Surgical Techniques and Robotic Techniques for Cochlear Implantation in Terms of the Trajectories Toward the Inner Ear.

Author

Topsakal, Vedat, Matulic, Marco, Assadi, Masoud Zoka, Mertens, Griet, Van Rompaey, Vincent, and Van de Heyning, Paul

Subjects
*INNER ear, *OPERATIVE surgery, *EAR ossicles, *SURGICAL robots, *EAR canal, *COCHLEAR implants
Abstract

OBJECTIVES: The ideal outcome of cochlear implant surgery involves the insertion of the array inside the scala tympani of the cochlea with the least mechanical trauma. Recently, round window insertion and the direction in which the cochlea is approached have gained attention in this respect. The Angles of Cochlear Approach (ACA) can be defined with a plane in the plane of the basal turn, termed the in-plane angle, and the plane orthogonal to this plane, termed the out-plane angle. The aim of this study was to compare the trajectory angles for different surgical techniques of Veria, suprameatal, pericanal, and multiple posterior tympanotomy (PT) approaches, including an optimal trajectory that is simulated for robotic surgery. MATERIALS and METHODS: The trajectories of these surgical techniques were simulated on the same high-resolution computed tomography scan. The simulated trajectory angles were analyzed with dedicated software for medical images, defining the ACA and distances to critical otological structures. RESULTS: The ACA are the smallest for surgical techniques that pass thought the PT. However, performing a surgical PT can include variability in the ACA, ranging from almost 0° to 20.8° in an out-plane angle, depending on how close a surgeon would approach the facial nerve. The Veria, Suprameatal approach (SMA), and peri-canal approaches have larger ACA and minimal distances to the ossicular chain and the ear canal. The maximum distance to the facial nerve and the widest out-plane angle is observe with a pericanal approach. The optimal PT approach refers to the trajectory without collisions and with the best possible ACA that can be planned. CONCLUSION: Different surgical approaches yield important differences in the ACA. PT allows better ACA with maximum distances to the critical structures. However, the optimal PT trajectory simulated for robotic keyhole surgery is a further improvement on the trajectories through the facial recess. [ABSTRACT FROM AUTHOR]

Published
2020
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48. Stable benefits of bilateral over unilateral cochlear implantation after two years : A randomized controlled trial

Author

van Zon, Alice, Smulders, Yvette E, Stegeman, Inge, Ramakers, Geerte G J, Kraaijenga, Veronique J C, Koenraads, Simone P C, van Zanten, Gijsbert A, Rinia, Albert B, Stokroos, Robert J, Free, Rolien H, Frijns, Johan H M, Huinck, Wendy J, Mylanus, Emmanuel A M, Tange, Rinze A, Smit, Adriana L, Thomeer, Hans G X M, Topsakal, Vedat, Grolman, Wilko, van Zon, Alice, Smulders, Yvette E, Stegeman, Inge, Ramakers, Geerte G J, Kraaijenga, Veronique J C, Koenraads, Simone P C, van Zanten, Gijsbert A, Rinia, Albert B, Stokroos, Robert J, Free, Rolien H, Frijns, Johan H M, Huinck, Wendy J, Mylanus, Emmanuel A M, Tange, Rinze A, Smit, Adriana L, Thomeer, Hans G X M, Topsakal, Vedat, and Grolman, Wilko

Published
2017

50. Stable benefits of bilateral over unilateral cochlear implantation after two years: A randomized controlled trial

Author

MS KNO, Brain, Audiologen, Other research (not in main researchprogram), van Zon, Alice, Smulders, Yvette E, Stegeman, Inge, Ramakers, Geerte G J, Kraaijenga, Veronique J C, Koenraads, Simone P C, van Zanten, Gijsbert A, Rinia, Albert B, Stokroos, Robert J, Free, Rolien H, Frijns, Johan H M, Huinck, Wendy J, Mylanus, Emmanuel A M, Tange, Rinze A, Smit, Adriana L, Thomeer, Hans G X M, Topsakal, Vedat, Grolman, Wilko, MS KNO, Brain, Audiologen, Other research (not in main researchprogram), van Zon, Alice, Smulders, Yvette E, Stegeman, Inge, Ramakers, Geerte G J, Kraaijenga, Veronique J C, Koenraads, Simone P C, van Zanten, Gijsbert A, Rinia, Albert B, Stokroos, Robert J, Free, Rolien H, Frijns, Johan H M, Huinck, Wendy J, Mylanus, Emmanuel A M, Tange, Rinze A, Smit, Adriana L, Thomeer, Hans G X M, Topsakal, Vedat, and Grolman, Wilko

Published
2017

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