1. The use of venous blood gas in assessing arterial acid-base and oxygenation status - an analysis of aggregated data from multiple studies evaluating the venous to arterial conversion (v-TAC) method.
- Author
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Shastri, L, Thomsen, LP, Toftegaard, M, Tygesen, GB, Weinreich, UM, Rychwicka-Kielek, BA, Davies, MG, Ekström, M, Rittger, H, Kelly, A-M, Kristensen, SR, Kjærgaard, S, Kamperidis, P, Manuel, A, Damgaard, KA, Andreassen, S, Rees, SE, Shastri, L, Thomsen, LP, Toftegaard, M, Tygesen, GB, Weinreich, UM, Rychwicka-Kielek, BA, Davies, MG, Ekström, M, Rittger, H, Kelly, A-M, Kristensen, SR, Kjærgaard, S, Kamperidis, P, Manuel, A, Damgaard, KA, Andreassen, S, and Rees, SE
- Abstract
BACKGROUND: Several methods exist to reduce the number of arterial blood gases (ABGs). One method, Roche v-TAC, has been evaluated in different patient groups. This paper aggregates data from these studies, in different patient categories using common analysis criteria. RESEARCH DESIGN AND METHODS: We included studies evaluating v-TAC based on paired arterial and peripheral venous blood samples. Bland-Altman analysis compared measured and calculated arterial values of pH, PCO2, and PO2. Subgroup analyses were performed for normal, chronic hypercapnia and chronic base excess, acute hyper- and hypocapnia, and acute and chronic base deficits. RESULTS: 811 samples from 12 studies were included. Bias and limits of agreement for measured and calculated values: pH 0.001 (-0.029 to 0.031), PCO2 -0.08 (-0.65 to 0.49) kPa, and PO2 0.04 (-1.71 to 1.78) kPa, with similar values for all sub-group analyses. CONCLUSION: These data suggest that v-TAC analysis may have a role in replacing ABGs, avoiding arterial puncture. Substantial data exist in patients with chronic hypercapnia and chronic base excess, acute hyper- and hypocapnia, and in patients with relatively normal acid-base status, with similar bias and precision across groups and across study data. Limited data exist for patients with acute and chronic base deficits.
- Published
- 2024