1. Preparation and evaluation of (99m)Tc-DMSA lyophilized kit for renal imaging.
- Author
-
Jan SU and Abbass HG
- Subjects
- Animals, Drug Stability, Female, Freeze Drying methods, Kidney metabolism, Rabbits, Radiometry methods, Radionuclide Imaging methods, Radiopharmaceuticals chemical synthesis, Radiopharmaceuticals pharmacokinetics, Technetium Tc 99m Dimercaptosuccinic Acid chemical synthesis, Technetium Tc 99m Dimercaptosuccinic Acid pharmacokinetics, Temperature, Kidney diagnostic imaging, Radiopharmaceuticals chemistry, Reagent Kits, Diagnostic, Technetium Tc 99m Dimercaptosuccinic Acid chemistry
- Abstract
Dimercaptosuccinic acid (DMSA) has been evaluated and used with technetium 99m ((99m)Tc) in imaging of kidneys. DMSA lyophilized kits were prepared and radiolabelled with (99m)Tc. Paper and thin-layer chromatography have been employed using various eluent systems for the radiochemical analysis, percentage labeling and binding capacity of (99m)Tc-DMSA. Female albino rabbits were used for this study. Biological data obtained after intravenous injection of radiolabelled DMSA to female albino rabbits revealed 32.42% uptake and long retention time in the kidneys. On the basis of animal biodistribution data, it is suggested that DMSA when labeled with (99m)Tc is useful complex for renal imaging and can be successfully applied as a diagnostic tool in nuclear medicine. Clinical biodistribution and radiation dosimetry studies are planned in future.
- Published
- 2013