Search

Your search keyword '"Taniguchi, Ataru"' showing total 47 results
Start Over Author "Taniguchi, Ataru" Search Limiters Available in Library Collection
47 results on '"Taniguchi, Ataru"'

3. Lipopolysaccharide inhibits hepatic gluconeogenesis in rats: The role of immune cell

Author

Tanaka, Hiroshi, Nishikawa, Yoshikazu, Fukushima, Toru, Taniguchi, Ataru, Fujita, Yoshihito, Tsuda, Kinsuke, Inagaki, Nobuya, and Hosokawa, Masaya

Subjects
endocrine system diseases, Liver, nutritional and metabolic diseases, Lipopolysaccharide, Spleen
Abstract

Aims/Introduction: Bacterial septicemia has diverse clinical symptoms including severe hypoglycemia. However, sepsis‐induced hypoglycemia has not yet been examined in detail. The aim of the present study was to investigate the mechanisms underlying hypoglycemia in sepsis., Materials and Methods: We induced endotoxin shock in rats using lipopolysaccharide (LPS). After an intraperitoneal injection of LPS, we measured gluconeogenesis using the pyruvate tolerance test. The effects of LPS on glucose metabolism were investigated in perfused livers and isolated hepatocytes. Furthermore, its effects on the production of inflammatory cytokines were examined in isolated splenocytes. The interaction between splenocytes and hepatocytes in response to LPS was investigated in vitro using a co‐culture of splenocytes and hepatocytes., Results: In the pyruvate tolerance test, the pretreatment with LPS decreased gluconeogenesis. The in vivo pretreatment of rats with LPS did not inhibit glucose production in perfused livers. The in vitro treatment of isolated hepatocytes with LPS did not decrease hepatic gluconeogenesis. Although LPS increased the production of inflammatory cytokines (tumor necrosis factor‐α, interferon‐γ, interleukin‐1β, interleukin‐6 and interleukin‐10) and nitric oxide in isolated splenocytes, only nitric oxide significantly inhibited gluconeogenesis in isolated hepatocytes. When splenocytes and hepatocytes were co‐cultured in medium containing LPS, the messenger ribonucleic acid expression of glucose‐6‐phosphatase in hepatocytes was suppressed., Conclusions: LPS reduced hepatic gluconeogenesis, at least in part, by stimulating the production of nitric oxide in splenocytes. This effect could contribute to the mechanisms responsible for septicemia‐induced hypoglycemia.

Published
2018

27. Lipopolysaccharide inhibits hepatic gluconeogenesis in rats: The role of immune cell

Author

50547809, 30241954, Tanaka, Hiroshi, Nishikawa, Yoshikazu, Fukushima, Toru, Taniguchi, Ataru, Fujita, Yoshihito, Tsuda, Kinsuke, Inagaki, Nobuya, Hosokawa, Masaya, 50547809, 30241954, Tanaka, Hiroshi, Nishikawa, Yoshikazu, Fukushima, Toru, Taniguchi, Ataru, Fujita, Yoshihito, Tsuda, Kinsuke, Inagaki, Nobuya, and Hosokawa, Masaya

Abstract

Aims/Introduction: Bacterial septicemia has diverse clinical symptoms including severe hypoglycemia. However, sepsis‐induced hypoglycemia has not yet been examined in detail. The aim of the present study was to investigate the mechanisms underlying hypoglycemia in sepsis., Materials and Methods: We induced endotoxin shock in rats using lipopolysaccharide (LPS). After an intraperitoneal injection of LPS, we measured gluconeogenesis using the pyruvate tolerance test. The effects of LPS on glucose metabolism were investigated in perfused livers and isolated hepatocytes. Furthermore, its effects on the production of inflammatory cytokines were examined in isolated splenocytes. The interaction between splenocytes and hepatocytes in response to LPS was investigated in vitro using a co‐culture of splenocytes and hepatocytes., Conclusions: LPS reduced hepatic gluconeogenesis, at least in part, by stimulating the production of nitric oxide in splenocytes. This effect could contribute to the mechanisms responsible for septicemia‐induced hypoglycemia.

Published
2018

30. Serum Lipid Levels in Patients with Eating Disorders

Author

Nakai, Yoshikatsu, Noma, Shun'ichi, Fukusima, Mitsuo, Taniguchi, Ataru, Teramukai, Satoshi, Nakai, Yoshikatsu, Noma, Shun'ichi, Fukusima, Mitsuo, Taniguchi, Ataru, and Teramukai, Satoshi

Abstract

[Objective] To evaluate some risk factors for cardiovascular diseases in feeding and eating disorders, the degree of lipid abnormalities was investigated in a large Japanese cohort of different groups of feeding and eating disorders, according to the Japan Atherosclerosis Society Guidelines for the Prevention of Atherosclerotic Cardiovascular Diseases 2012 (JAS Guidelines 2012). [Methods] Participants in the current study included 732 women divided into four groups of feeding and eating disorders: anorexia nervosa, restricting type (AN-R); anorexia nervosa, binge-eating/purging type; bulimia nervosa (BN); and binge-eating disorder (BED). We measured the serum levels of total cholesterol, high-density-lipoprotein (HDL) cholesterol, and triglyceride in these participants. Low-density-lipoprotein (LDL) cholesterol and non-HDL cholesterol levels were also calculated. [Results] The concentrations of LDL cholesterol and non-HDL cholesterol were widely distributed in all groups. When the LDL cholesterol risk was defined as ≥120 mg/dL and the non-HDL cholesterol risk as ≥150 mg/dL, according to the JAS Guidelines 2012, the proportion of LDL cholesterol risk ranged from 29.6% (BN) to 38.6% (AN-R), and the proportion of non-HDL cholesterol risk ranged from 17.8% (BN) to 30.1% (BED). [Conclusion] The present findings suggest the existence of LDL cholesterol risk and non-HDL cholesterol risk in all groups of eating disorders. Given the chronicity of this condition, the development of elevated concentrations of LDL cholesterol and non-HDL cholesterol at an early age may increase the risk of cardiovascular diseases.

Published
2016

31. Insulin secretory defect and insulin resistance in isolated impaired fasting glucose and isolated impaired glucose tolerance

Author

60378643, 30241954, Aoyama-Sasabe, Sae, Fukushima, Mitsuo, Xin, Xin, Taniguchi, Ataru, Nakai, Yoshikatsu, Mitsui, Rie, Takahashi, Yoshitaka, Tsuji, Hideaki, Yabe, Daisuke, Yasuda, Koichiro, Kurose, Takeshi, Inagaki, Nobuya, Seino, Yutaka, 60378643, 30241954, Aoyama-Sasabe, Sae, Fukushima, Mitsuo, Xin, Xin, Taniguchi, Ataru, Nakai, Yoshikatsu, Mitsui, Rie, Takahashi, Yoshitaka, Tsuji, Hideaki, Yabe, Daisuke, Yasuda, Koichiro, Kurose, Takeshi, Inagaki, Nobuya, and Seino, Yutaka

Published
2016

33. Insulin Secretory Defect and Insulin Resistance in Isolated Impaired Fasting Glucose and Isolated Impaired Glucose Tolerance

Author

Aoyama-Sasabe, Sae, primary, Fukushima, Mitsuo, additional, Xin, Xin, additional, Taniguchi, Ataru, additional, Nakai, Yoshikatsu, additional, Mitsui, Rie, additional, Takahashi, Yoshitaka, additional, Tsuji, Hideaki, additional, Yabe, Daisuke, additional, Yasuda, Koichiro, additional, Kurose, Takeshi, additional, Inagaki, Nobuya, additional, and Seino, Yutaka, additional

Published
2016
Full Text
View/download PDF

34. Circulating TNF Receptor 2 is Closely Associated with the Kidney Function in Non-Diabetic Japanese Subjects

Author

Kurashina, Tomoyuki, primary, Nagasaka, Shoichiro, additional, Watanabe, Naoya, additional, Yabe, Daisuke, additional, Sugi, Noriko, additional, Nin, Kazuko, additional, Hosokawa, Masaya, additional, Nomura, Yoshio, additional, Fukushima, Mitsuo, additional, Nakai, Yoshikatsu, additional, Nishimura, Fusanori, additional, and Taniguchi, Ataru, additional

Published
2014
Full Text
View/download PDF

35. The inflammation–lipocalin 2 axis may contribute to the development of chronic kidney disease

Author

Hashikata, Atsushi, primary, Yamashita, Akiko, additional, Suzuki, Shigeki, additional, Nagayasu, Shintaro, additional, Shinjo, Takanori, additional, Taniguchi, Ataru, additional, Fukushima, Mitsuo, additional, Nakai, Yoshikatsu, additional, Nin, Kazuko, additional, Watanabe, Naoya, additional, Asano, Tomoichiro, additional, Abiko, Yoshimitsu, additional, Kushiyama, Akifumi, additional, Nagasaka, Shoichiro, additional, and Nishimura, Fusanori, additional

Published
2013
Full Text
View/download PDF

36. Smoking and adipose tissue inflammation suppress leptin expression in Japanese obese males: Potential mechanism of resistance to weight loss among Japanese obese smokers

Author

Nagayasu, Shintaro, primary, Suzuki, Shigeki, additional, Yamashita, Akiko, additional, Taniguchi, Ataru, additional, Fukushima, Mitsuo, additional, Nakai, Yoshikatsu, additional, Watanabe, Naoya, additional, Nagasaka, Shoichiro, additional, Yabe, Daisuke, additional, Nishimura, Fusanori, additional, and Nin, Kazuko, additional

Published
2012
Full Text
View/download PDF

37. Pitavastatin Reduces Elevated IL-18 Levels in Japanese Subjects with Hypercholesterolemia: Sub-analysis of Kansai Investigation of Statin for Hyperlipidemic Intervention in Metabolism and Endocrinology (KISHIMEN)

Author

Fujioka, Yoshio, primary, Fukuda, Akira, additional, Ishida, Tatsuro, additional, Kagimoto, Shinji, additional, Nakamura, Yoshio, additional, Iwakura, Akane, additional, Hara, Kyoko, additional, Yamamoto, Taizo, additional, Kuroe, Akira, additional, Ohya, Michihiro, additional, Fujimoto, Shinpei, additional, Hamamoto, Yoshiyuki, additional, Honjo, Sachiko, additional, Ikeda, Hiroki, additional, Nabe, Koichiro, additional, Tsuda, Kinsuke, additional, Taniguchi, Ataru, additional, Tanaka, Kiyoshi, additional, Koshiyama, Hiroyuki, additional, Kume, Noriaki, additional, and Hirata, Ken-ichi, additional

Published
2011
Full Text
View/download PDF

38. Smoking, white blood cell counts, and TNF system activity in Japanese male subjects with normal glucose tolerance

Author

Watanabe, Naoya, primary, Fukushima, Mitsuo, additional, Taniguchi, Ataru, additional, Okumura, Takahide, additional, Nomura, Yoshio, additional, Nishimura, Fusanori, additional, Aoyama, Sae, additional, Yabe, Daisuke, additional, Izumi, Yoshio, additional, Ohtsubo, Ryoichi, additional, Nakai, Yoshikatsu, additional, and Nagasaka, Shoichiro, additional

Published
2011
Full Text
View/download PDF

39. Effects of Pitavastatin on Lipid Profiles and High-Sensitivity CRP in Japanese Subjects with Hypercholesterolemia: Kansai Investigation of Statin for Hyperlipidemic Intervention in Metabolism and Endocrinology (KISHIMEN) Investigatars

Author

Koshiyama, Hiroyuki, primary, Taniguchi, Ataru, additional, Tanaka, Kiyoshi, additional, Kagimoto, Shinji, additional, Fujioka, Yoshio, additional, Hirata, Kenichi, additional, Nakamura, Yoshio, additional, Iwakura, Akane, additional, Hara, Kyoko, additional, Yamamoto, Taizo, additional, Kuroe, Akira, additional, Ohya, Michihiro, additional, Fujimoto, Shimpei, additional, Hamamoto, Yoshiyuki, additional, Honjo, Sachiko, additional, Ikeda, Hiroki, additional, Nabe, Koichiro, additional, Tsuda, Kinsuke, additional, Inagaki, Nobuya, additional, Seino, Yutaka, additional, and Kume, Noriaki, additional

Published
2008
Full Text
View/download PDF

40. Insulin Secretory Defect and Insulin Resistance in Isolated Impaired Fasting Glucose and Isolated Impaired Glucose Tolerance.

Author

Aoyama-Sasabe, Sae, Fukushima, Mitsuo, Xin, Xin, Taniguchi, Ataru, Nakai, Yoshikatsu, Mitsui, Rie, Takahashi, Yoshitaka, Tsuji, Hideaki, Yabe, Daisuke, Yasuda, Koichiro, Kurose, Takeshi, Inagaki, Nobuya, and Seino, Yutaka

Subjects
INSULIN resistance, GLUCOSE intolerance, GLUCOSE tolerance tests, STATISTICAL correlation, COMPARATIVE studies
Abstract

Objective. To investigate the characteristics of isolated impaired glucose tolerance (IGT) and isolated impaired fasting glucose (IFG), we analyzed the factors responsible for elevation of 2-hour postchallenge plasma glucose (2 h PG) and fasting plasma glucose (FPG) levels. Methods. We investigated the relationship between 2 h PG and FPG levels who underwent 75 g OGTT in 5620 Japanese subjects at initial examination for medical check-up. We compared clinical characteristics between isolated IGT and isolated IFG and analyzed the relationships of 2 h PG and FPG with clinical characteristics, the indices of insulin secretory capacity, and insulin sensitivity. Results. In a comparison between isolated IGT and isolated IFG, insulinogenic index was lower in isolated IGT than that of isolated IFG (0.43 ± 0.34 versus 0.50 ± 0.47, resp.; p<0.01). ISI composite was lower in isolated IFG than that of isolated IGT (6.87 ± 3.38 versus 7.98 ± 4.03, resp.; p<0.0001). In isolated IGT group, insulinogenic index showed a significant correlation with 2 h PG (r=-0.245, p<0.0001) and had the strongest correlation with 2 h PG (β=-0.290). In isolated IFG group, ISI composite showed a significant correlation with FPG (r=-0.162, p<0.0001) and had the strongest correlation with FPG (β=-0.214). Conclusions. We have elucidated that decreased early-phase insulin secretion is the most important factor responsible for elevation of 2 h PG levels in isolated IGT subjects, and decreased insulin sensitivity is the most important factor responsible for elevation of FPG levels in isolated IFG subjects. [ABSTRACT FROM AUTHOR]

Published
2015
Full Text
View/download PDF

44. LETTERS.

Author

Davidson, Mayer B., Taniguchi, Ataru, Nagata, Itaru, Okumura, Takahide, Sakai, Masahiko, Fukushima, Mitsuo, Nagasaka, Shoichoro, Matsumoto, Kazunari, Tokuyama, Kumpei, Doi, Kentaro, Nakai, Yoshikatsu, Vakkilainen, Juha, Perttunen-Nio, Helina, Taskinen, Marja-Riitta, Steiner, George, Ansquer, Jean-Claude, Bosnak, Mehmet, Dikici, Bunyamin, Dogru, Omer, and Davutoglu, Mehmet

Subjects
*DIABETES, *RESEARCH grants, *FENOFIBRATE, *TYPE 2 diabetes
Abstract

Presents comments on studies about diabetes. Status of research funded by the American Diabetes Association as of March 2002; Comparison of insulin sensitivity indexes among non-obese Japanese type 2 diabetic patients; Physiological effects of fenofibrate on type 2 diabetic patients.

Published
2002

45. Influence of chronic hyperprolactinemia induced by sulpiride on the hypothalamo-pituitary-testicular axis in normal men**Supported in part by the Ministry of Education of Japan grant 44381.

Author

Oseko, Fumimaro, Note, Shinya, Morikawa, Keiko, Endo, Jiro, Taniguchi, Ataru, and Imura, Hiroo

Abstract

For elucidation of the effects of hyperprolactinemia on the hypothalamic-pituitary-testicular axis, five healthy men were exposed to sulpiride (300 mg/day by mouth); four among the five maintained hyperprolactinemia (71.6 to 95.3 ng/ml) for 78 days. Clomiphene citrate (CC), luteinizing hormone (LH)-releasing hormone, and human chorionic gonadotropin tests were performed before and after sulpiride treatment. The CC test, given as a measure of hypothalamic function, was carried out in each of the five volunteers before sulpiride treatment (control) and on days 14 (2 weeks) and 60 (2 months) of sulpiride administration. Each value of plasma LH stimulated by CC was integrated and expressed as a ratio of the integrated value obtained after administering CC at 2 weeks and 2 months to that from each control experiment. The mean ratio in the four subjects at 2 months (mean ± standard deviation, 0.769 ± 0.121) was significantly lower than that at 2 weeks (0.942 ± 0.073; P< 0.05) and before sulpiride treatment (1.000; P< 0.01). Impairment of LH responses to CC by 2-month long sulpiride-induced hyperprolactinemia suggests that chronic hyperprolactinemia in men partly suppresses LH secretion by its inhibitory action on the hypothalamus.

Published
1985
Full Text
View/download PDF

46. SHORT REPORTS.

Author

Oseko, Fumimaro, Note, Shinya, Taniguchi, Ataru, Kono, Tsuyoshi, Imura, Hiroo, Lewis-Jones, M.S., Evans, S., Culshaw, M.A., Cunningham, David, Soukop, Michael, Gilchrist, Nigel L., Forrest, Gordon J., Hepplestone, Andrew, Calder, Ian T., McArdle, Colin S., Hutcheon, Andrew W., and Kaye, Stanley B.

Subjects
MEDICINE, ZINC deficiency diseases, VOMITING treatment
Abstract

Reports developments related to medicine in Great Britain as of February 1985. Absence of response to plasma prolactin concentrations to symptomatic hypoglycemia induced by insulin; Manifestations of zinc deficiency diseases during treatment with anticonvulsants; Treatment of emesis induced by cytotoxic drugs.

Published
1985

47. Porphyromonas gingivalis Infection With Elevated C-Reactive Protein in Nonobese Japanese Type 2 Diabetic Subjects.

Author

Nishimura, Fusanori, Iwamoto, Yoshihiro, Soga, Yoshihiko, Murayama, Yoji, Taniguchi, Ataru, Fukushima, Mitsuo, Nagasaka, Shoichiro, and Nakai, Yoshikatsu

Subjects
CORONARY heart disease risk factors, C-reactive protein, PORPHYROMONAS gingivalis infections, PHYSIOLOGY
Abstract

Examines the association of having porphyromonas gingivalis infection with elevated C-reactive protein (CRP) among nonobese type 2 diabetic Japanese. Increase risk of coronary heart disease; Negative significant correlation between highly sensitive CRP; Significance of periodontal infection in the development of cardiovascular disease.

Published
2002
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results