Search

Your search keyword '"Tang, Man Wai"' showing total 23 results
Start Over Author "Tang, Man Wai" Search Limiters Available in Library Collection
23 results on '"Tang, Man Wai"'

1. Azathioprine/hydroxyurea preconditioning prior to nonmyeloablative matched sibling donor hematopoietic stem cell transplantation in adults with sickle cell disease: A prospective observational cohort study

Author

Dovern, Elisabeth, primary, Aydin, Mesire, additional, Hazenberg, Mette D., additional, Tang, Man Wai, additional, Suijk, Elisabeth M., additional, Hoogendoorn, Gerianne M., additional, Van Tuijn, Charlotte F. J., additional, Kerkhoffs, Jean‐Louis, additional, Rutten, Caroline E., additional, Zeerleder, Sacha S., additional, de la Fuente, Josu, additional, Biemond, Bart J., additional, and Nur, Erfan, additional

Published
2024
Full Text
View/download PDF

3. Comparison of Hidac Versus FLAG-IDA in the Treatment of Relapsed Acute Myeloid Leukemia and Myelodysplastic Syndrome: A Retrospective Study

Author

Tang, Man Wai, primary, van der Tuin, Deborah, additional, Aydin, Mesire, additional, Heijmans, Jarom, additional, van de Loosdrecht, Arjan A., additional, Meijer, Ellen, additional, Rutten, Caroline E., additional, Wondergem, Marielle, additional, Janssen, Jeroen J.W.M., additional, Donker, Marjolein, additional, Hazenberg, Mette D., additional, Zweegman, Sonja, additional, Biemond, Bart J., additional, de Leeuw, David C., additional, and Nur, Erfan, additional

Published
2022
Full Text
View/download PDF

4. Improved T-Cell Chimerism and Successful Withdrawal of Immunosuppression after Non-Myeloablative Stem Cell Transplantation for Sickle Cell Disease with Azathioprine/Hydroxyurea Preconditioning Added to Alemtuzumab/TBI Conditioning

Author

Dovern, Elisabeth, primary, Aydin, Mesire, additional, Tang, Man Wai, additional, Suijk, Liesbeth E.M., additional, Hoogendoorn, Gerianne M., additional, Van Tuijn, Charlotte F.J., additional, Kerkhoffs, Jean-Louis, additional, Rutten, Caroline E., additional, Zeerleder, Sacha S., additional, Hazenberg, Mette D., additional, Biemond, Bart J., additional, and Nur, Erfan, additional

Published
2022
Full Text
View/download PDF

8. High-Dose Melphalan in 1 Day Versus over 2 Days Followed By Autologous Stem Cell Transplantation As Consolidation Treatment in Patients with Multiple Myeloma

Author

Aydin, Mesire, primary, Tang, Man Wai, additional, Wondergem, Marielle, additional, de Leeuw, David C., additional, Wegman, Jurgen J., additional, Biemond, Bart J., additional, van de Donk, Niels W.C.J., additional, Zweegman, Sonja, additional, Meijer, Ellen, additional, and Nur, Erfan, additional

Published
2021
Full Text
View/download PDF

11. Novel cyclic ketones for catalytic oxidation reactions

Author

Yang, Dan, Yip, Yiu-Chung, Tang, Man-Wai, Wong, Man-Kin, and Cheung, Kung-Kai

Subjects
Ketones -- Usage, Catalysts -- Research, Oxidation-reduction reaction -- Equipment and supplies, Cyclic compounds -- Analysis, Biological sciences, Chemistry
Abstract

A series of cyclic ketones with better catalytic properties have been synthesized from the corresponding diacids. The derived ketones are highly effective in catalyzing the oxidation of olefins due to their steric and electronic effects as well as the ring strains. Ketone recovery is greater than 90% and product yield is excellent in the epoxidation of olefins and catalysis of alcohols. The synthesized ketones are robust, recyclable and environment-friendly catalysts that should find wide use in oxidation reactions.

Published
1998

12. Promotion of macrophage activation by Tie2 in the context of the inflamed synovia of rheumatoid arthritis and psoriatic arthritis patients

Author

Kabala, Pawel A, primary, Malvar-Fernández, Beatriz, additional, Lopes, Ana P, additional, Carvalheiro, Tiago, additional, Hartgring, Sarita A Y, additional, Tang, Man Wai, additional, Conde, Carmen, additional, Baeten, Dominique L, additional, Sleeman, Matthew, additional, Tak, Paul P, additional, Connor, Jane, additional, Radstake, Timothy R, additional, Reedquist, Kris A, additional, and García, Samuel, additional

Published
2019
Full Text
View/download PDF

15. Class 3 semaphorins modulate the invasive capacity of rheumatoid arthritis fibroblast-like synoviocytes

Author

Translationele immunologie, Infection & Immunity, Other research (not in main researchprogram), Tang, Man Wai, Malvar Fernández, Beatriz, Newsom, Simon P., van Buul, Jaap D., Radstake, Timothy R.D.J., Baeten, Dominique L., Tak, Paul P., Reedquist, Kris A., García, Samuel, Translationele immunologie, Infection & Immunity, Other research (not in main researchprogram), Tang, Man Wai, Malvar Fernández, Beatriz, Newsom, Simon P., van Buul, Jaap D., Radstake, Timothy R.D.J., Baeten, Dominique L., Tak, Paul P., Reedquist, Kris A., and García, Samuel

Published
2018

18. Promotion of macrophage activation by Tie2 in the context of the inflamed synovia of rheumatoid arthritis and psoriatic arthritis patients.

Author

Kabala, Pawel A, Malvar-Fernández, Beatriz, Lopes, Ana P, Carvalheiro, Tiago, Hartgring, Sarita A Y, Tang, Man Wai, Conde, Carmen, Baeten, Dominique L, Sleeman, Matthew, Tak, Paul P, Connor, Jane, Radstake, Timothy R, Reedquist, Kris A, and García, Samuel

Subjects
ANIMAL experimentation, BONE marrow examination, CELL physiology, CELL receptors, CELLULAR signal transduction, CHEMOKINES, CYTOKINES, IMMUNITY, INTERLEUKINS, MACROPHAGES, MICE, MONOCYTES, OXIDOREDUCTASES, PROTEINS, PSORIATIC arthritis, RHEUMATOID arthritis, TUMOR necrosis factors, SYNOVITIS
Abstract

Objective To examine the role of Tie2 signalling in macrophage activation within the context of the inflammatory synovial microenvironment present in patients with RA and PsA. Methods Clinical responses and macrophage function were examined in wild-type and Tie2-overexpressing (Tie2-TG) mice in the K/BxN serum transfer model of arthritis. Macrophages derived from peripheral blood monocytes from healthy donors, RA and PsA patients, and RA and PsA synovial tissue explants were stimulated with TNF (10 ng/ml), angiopoietin (Ang)-1 or Ang-2 (200 ng/ml), or incubated with an anti-Ang2 neutralizing antibody. mRNA and protein expression of inflammatory mediators was analysed by quantitative PCR, ELISA and Luminex. Results Tie2-TG mice displayed more clinically severe arthritis than wild-type mice, accompanied by enhanced joint expression of IL6 , IL12B , NOS2 , CCL2 and CXCL10 , and activation of bone marrow-derived macrophages in response to Ang-2 stimulation. Ang-1 and Ang-2 significantly enhanced TNF-induced expression of pro-inflammatory cytokines and chemokines in macrophages from healthy donors differentiated with RA and PsA SF and peripheral blood-derived macrophages from RA and PsA patients. Both Ang-1 and Ang-2 induced the production of IL-6, IL-12p40, IL-8 and CCL-3 in synovial tissue explants of RA and PsA patients, and Ang-2 neutralization suppressed the production of IL-6 and IL-8 in the synovial tissue of RA patients. Conclusion Tie2 signalling enhances TNF-dependent activation of macrophages within the context of ongoing synovial inflammation in RA and PsA, and neutralization of Tie2 ligands might be a promising therapeutic target in the treatment of these diseases. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

20. The prolactin receptor is expressed in rheumatoid arthritis and psoriatic arthritis synovial tissue and contributes to macrophage activation

Author

Tang, Man Wai, primary, Reedquist, Kris A., additional, Garcia, Samuel, additional, Fernandez, Bea Malvar, additional, Codullo, Veronica, additional, Vieira-Sousa, Elsa, additional, Goffin, Vincent, additional, Reuwer, Anne Q., additional, Twickler, Marcel T., additional, Gerlag, Daniëlle M., additional, and Tak, Paul-Peter, additional

Published
2016
Full Text
View/download PDF

21. Synovial IL-21/TNF-producing CD4+T cells induce joint destruction in rheumatoid arthritis by inducing matrix metalloproteinase production by fibroblast-like synoviocytes

Author

Lebre, Maria C., Vieira, Pedro L., Tang, Man Wai, Aarrass, Saïda, Helder, Boy, Newsom-Davis, Thomas, Tak, Paul P., and Screaton, Gavin R.

Abstract

Synovial IL-21+TNF+CD4+T cells induce matrix metalloproteinase production by fibroblast-like synoviocytes in RA patients. Bone and cartilage destruction is one of the key manifestations of rheumatoid arthritis (RA). Although the role of T helper (Th)17 cells in these processes is clear, the role of IL-21–producing cells T cells has been neglected. We sought to investigate the role of IL-21 in RA by focusing on the functional characteristics of the main producers of this cytokine, synovial CD4+IL-21+T cells. We show that the frequency of both synovial fluid (SF) CD4+IL-21+or CD4+IL-21+TNF+T cells in patients with RA was significantly higher compared with patients with psoriatic arthritis (PsA). The frequency of peripheral blood (PB) IL-21+CD4+T cells in patients with RA positively correlated with disease activity score 28 (DAS28), serum anticyclic citrullinated peptide (anti-CCP) antibodies and IgM-rheumatoid factor (IgM-RF). IL-21 levels in RA SF were associated with matrix metalloproteinase (MMP)-1 and MMP-3. Related to this, IL-21 induced significantly the secretion of MMP-1 and MMP-3 in RA synovial biopsies. Sorted SF CD4+IL-21+T cells significantly induced the release of MMP-1 and MMP-3 by fibroblast-like synoviocytes (FLS) compared with medium or CD4+IL-21-T cells in a coculture system. Neutralization of both IL-21 and TNF resulted in significantly less production of MMP by FLS. The results of this study indicate a new role for synovial CD4+IL-21+TNF+T cells in promoting synovial inflammation/joint destruction in patients with RA. Importantly, IL-21 blockade in combination with anti-TNF might be an effective therapy in patients with RA by inhibiting MMP-induced inflammation/joint destruction.

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results