1. Hepatitis C virus infection among multi-transfused patients and personnel in haemodialysis units in central Islamic Republic of Iran.
- Author
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Samimi-Rad K, Hosseini M, Mobeini G, Asgari F, Alavian SM, Tahaei ME, and Salari H
- Subjects
- Adolescent, Adult, Blood Transfusion standards, Blood Transfusion trends, Child, Cross-Sectional Studies, Female, Hematologic Diseases genetics, Hematologic Diseases therapy, Hemodialysis Units, Hospital statistics & numerical data, Hepatitis C epidemiology, Hepatitis C etiology, Humans, Iran epidemiology, Male, Occupational Diseases epidemiology, Occupational Diseases etiology, Occupational Diseases prevention & control, Prevalence, Renal Dialysis statistics & numerical data, Risk Factors, Substance Abuse, Intravenous complications, Workforce, Young Adult, Hematologic Diseases complications, Hepatitis C prevention & control, Renal Dialysis adverse effects, Transfusion Reaction
- Abstract
A cross-sectional study was made of the prevalence of HCV and associated risk factors in 382 multi-transfused patients and haemodialysis staff in Yadz province in 2006. Of those tested for anti-HCV antibodies, 50.6% of patients with inherited bleeding disorders, 11.8% with thalassaemia and 5.0% undergoing haemodialysis were seropositive. First transfusion before 1996 (when blood donor screening started) was the common risk factor associated with HCV infection. Only 1/52 haemodialysis staff members was HCV infected (an intravenous drug user). Infection control measures were poor in all centres. In patients with inherited bleeding disorders genotype 1 (65.0%) was the predominant followed by genotype 3 (35.0%). The results provide evidence that blood donor screening and use of virus-inactivated factor concentrates have lowered the risk of HCV infection among multi-transfused patients.
- Published
- 2012
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