11 results on '"Tachinardi U"'
Search Results
2. Privacy-preserving record linkage across disparate institutions and datasets to enable a learning health system: The national COVID cohort collaborative (N3C) experience.
- Author
-
Tachinardi U, Grannis SJ, Michael SG, Misquitta L, Dahlin J, Sheikh U, Kho A, Phua J, Rogovin SS, Amor B, Choudhury M, Sparks P, Mannaa A, Ljazouli S, Saltz J, Prior F, Baghal A, Gersing K, and Embi PJ
- Abstract
Introduction: Research driven by real-world clinical data is increasingly vital to enabling learning health systems, but integrating such data from across disparate health systems is challenging. As part of the NCATS National COVID Cohort Collaborative (N3C), the N3C Data Enclave was established as a centralized repository of deidentified and harmonized COVID-19 patient data from institutions across the US. However, making this data most useful for research requires linking it with information such as mortality data, images, and viral variants. The objective of this project was to establish privacy-preserving record linkage (PPRL) methods to ensure that patient-level EHR data remains secure and private when governance-approved linkages with other datasets occur., Methods: Separate agreements and approval processes govern N3C data contribution and data access. The Linkage Honest Broker (LHB), an independent neutral party (the Regenstrief Institute), ensures data linkages are robust and secure by adding an extra layer of separation between protected health information and clinical data. The LHB's PPRL methods (including algorithms, processes, and governance) match patient records using "deidentified tokens," which are hashed combinations of identifier fields that define a match across data repositories without using patients' clear-text identifiers., Results: These methods enable three linkage functions: Deduplication, Linking Multiple Datasets, and Cohort Discovery. To date, two external repositories have been cross-linked. As of March 1, 2023, 43 sites have signed the LHB Agreement; 35 sites have sent tokens generated for 9 528 998 patients. In this initial cohort, the LHB identified 135 037 matches and 68 596 duplicates., Conclusion: This large-scale linkage study using deidentified datasets of varying characteristics established secure methods for protecting the privacy of N3C patient data when linked for research purposes. This technology has potential for use with registries for other diseases and conditions., Competing Interests: Jasmin Phua and Sara Rogovin are employed by Datavant, Inc. and Dr. Abel Kho has a financial interest in Datavant, Inc, a for‐profit company that was contracted to provided software, expertise, and services for the creation and operation of the PPRL approach described in this manuscript. Benjamin Amor, Maya Choudhury, Philip Sparks, Amin Mannaa, and Saad Ljazouli are employed by the for‐profit Palantir Technologies, which was contracted to provided software, expertise, and services for the creation and operation of the PPRL approach described in this manuscript. At the time that this work was performed, Drs. Peter Embi, Umberto Tachinardi, and Shaun Grannis all worked for and/or served as officers of Regenstrief Institute, Inc. a non‐profit research institute contracted by the NIH to manage and oversee the PPRL and LHB work described in this manuscript., (© 2024 The Authors. Learning Health Systems published by Wiley Periodicals LLC on behalf of University of Michigan.)
- Published
- 2024
- Full Text
- View/download PDF
3. Effect of the Affordable Care Act on diabetes care at major health centers: newly detected diabetes and diabetes medication management.
- Author
-
Furmanchuk A, Liu M, Song X, Waitman LR, Meurer JR, Osinski K, Stoddard A, Chrischilles E, McClay JC, Cowell LG, Tachinardi U, Embi PJ, Mosa ASM, Mandhadi V, Shah RC, Garcia D, Angulo F, Patino A, Trick WE, Markossian TW, Rasmussen-Torvik LJ, Kho AN, and Black BS
- Subjects
- Humans, Medicaid, Medication Therapy Management, United States, Diabetes Mellitus drug therapy, Diabetes Mellitus epidemiology, Patient Protection and Affordable Care Act
- Abstract
Competing Interests: Competing interests: None declared.
- Published
- 2021
- Full Text
- View/download PDF
4. Leveraging data visualization and a statewide health information exchange to support COVID-19 surveillance and response: Application of public health informatics.
- Author
-
Dixon BE, Grannis SJ, McAndrews C, Broyles AA, Mikels-Carrasco W, Wiensch A, Williams JL, Tachinardi U, and Embi PJ
- Subjects
- Health Information Exchange, Humans, Indiana epidemiology, United States, COVID-19 epidemiology, Data Visualization, Public Health Informatics, Public Health Surveillance methods
- Abstract
Objective: We sought to support public health surveillance and response to coronavirus disease 2019 (COVID-19) through rapid development and implementation of novel visualization applications for data amalgamated across sectors., Materials and Methods: We developed and implemented population-level dashboards that collate information on individuals tested for and infected with COVID-19, in partnership with state and local public health agencies as well as health systems. The dashboards are deployed on top of a statewide health information exchange. One dashboard enables authorized users working in public health agencies to surveil populations in detail, and a public version provides higher-level situational awareness to inform ongoing pandemic response efforts in communities., Results: Both dashboards have proved useful informatics resources. For example, the private dashboard enabled detection of a local community outbreak associated with a meat packing plant. The public dashboard provides recent trend analysis to track disease spread and community-level hospitalizations. Combined, the tools were utilized 133 637 times by 74 317 distinct users between June 21 and August 22, 2020. The tools are frequently cited by journalists and featured on social media., Discussion: Capitalizing on a statewide health information exchange, in partnership with health system and public health leaders, Regenstrief biomedical informatics experts rapidly developed and deployed informatics tools to support surveillance and response to COVID-19., Conclusions: The application of public health informatics methods and tools in Indiana holds promise for other states and nations. Yet, development of infrastructure and partnerships will require effort and investment after the current pandemic in preparation for the next public health emergency., (© The Author(s) 2021. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
- Published
- 2021
- Full Text
- View/download PDF
5. The Children's Respiratory and Environmental Workgroup (CREW) birth cohort consortium: design, methods, and study population.
- Author
-
Gern JE, Jackson DJ, Lemanske RF Jr, Seroogy CM, Tachinardi U, Craven M, Hwang SY, Hamilton CM, Huggins W, O'Connor GT, Gold DR, Miller R, Kattan M, Johnson CC, Ownby D, Zoratti EM, Wood RA, Visness CM, Martinez F, Wright A, Lynch S, Ober C, Khurana Hershey GK, Ryan P, Hartert T, and Bacharier LB
- Subjects
- Adolescent, Asthma genetics, Child, Child, Preschool, Cohort Studies, Environmental Exposure prevention & control, Female, Humans, Infant, Male, Young Adult, Asthma diagnosis, Asthma epidemiology, Environmental Exposure analysis, Life Style, Population Surveillance methods
- Abstract
Background: Single birth cohort studies have been the basis for many discoveries about early life risk factors for childhood asthma but are limited in scope by sample size and characteristics of the local environment and population. The Children's Respiratory and Environmental Workgroup (CREW) was established to integrate multiple established asthma birth cohorts and to investigate asthma phenotypes and associated causal pathways (endotypes), focusing on how they are influenced by interactions between genetics, lifestyle, and environmental exposures during the prenatal period and early childhood., Methods and Results: CREW is funded by the NIH Environmental influences on Child Health Outcomes (ECHO) program, and consists of 12 individual cohorts and three additional scientific centers. The CREW study population is diverse in terms of race, ethnicity, geographical distribution, and year of recruitment. We hypothesize that there are phenotypes in childhood asthma that differ based on clinical characteristics and underlying molecular mechanisms. Furthermore, we propose that asthma endotypes and their defining biomarkers can be identified based on personal and early life environmental risk factors. CREW has three phases: 1) to pool and harmonize existing data from each cohort, 2) to collect new data using standardized procedures, and 3) to enroll new families during the prenatal period to supplement and enrich extant data and enable unified systems approaches for identifying asthma phenotypes and endotypes., Conclusions: The overall goal of CREW program is to develop a better understanding of how early life environmental exposures and host factors interact to promote the development of specific asthma endotypes.
- Published
- 2019
- Full Text
- View/download PDF
6. Sustainability considerations for clinical and translational research informatics infrastructure.
- Author
-
Obeid JS, Tarczy-Hornoch P, Harris PA, Barnett WK, Anderson NR, Embi PJ, Hogan WR, Bell DS, McIntosh LD, Knosp B, Tachinardi U, Cimino JJ, and Wehbe FH
- Abstract
A robust biomedical informatics infrastructure is essential for academic health centers engaged in translational research. There are no templates for what such an infrastructure encompasses or how it is funded. An informatics workgroup within the Clinical and Translational Science Awards network conducted an analysis to identify the scope, governance, and funding of this infrastructure. After we identified the essential components of an informatics infrastructure, we surveyed informatics leaders at network institutions about the governance and sustainability of the different components. Results from 42 survey respondents showed significant variations in governance and sustainability; however, some trends also emerged. Core informatics components such as electronic data capture systems, electronic health records data repositories, and related tools had mixed models of funding including, fee-for-service, extramural grants, and institutional support. Several key components such as regulatory systems (e.g., electronic Institutional Review Board [IRB] systems, grants, and contracts), security systems, data warehouses, and clinical trials management systems were overwhelmingly supported as institutional infrastructure. The findings highlighted in this report are worth noting for academic health centers and funding agencies involved in planning current and future informatics infrastructure, which provides the foundation for a robust, data-driven clinical and translational research program.
- Published
- 2018
- Full Text
- View/download PDF
7. The Emerging Role of the Chief Research Informatics Officer in Academic Health Centers.
- Author
-
Sanchez-Pinto LN, Mosa ASM, Fultz-Hollis K, Tachinardi U, Barnett WK, and Embi PJ
- Subjects
- Information Technology, Salaries and Fringe Benefits statistics & numerical data, Surveys and Questionnaires, Workforce, Academic Medical Centers organization & administration, Medical Informatics
- Abstract
Background: The role of the Chief Research Informatics Officer (CRIO) is emerging in academic health centers to address the challenges clinical researchers face in the increasingly digitalized, data-intensive healthcare system. Most current CRIOs are the first officers in their institutions to hold that role. To date there is very little published information about this role and the individuals who serve it., Objective: To increase our understanding of the CRIO role, the leaders who serve it, and the factors associated with their success in their organizations., Methods: The Clinical Research Informatics Working Group of the American Medical Informatics Association (AMIA) conducted a national survey of CRIOs in the United States and convened an expert panel of CRIOs to discuss their experience during the 2016 AMIA Annual Symposium., Results: CRIOs come from diverse academic backgrounds. Most have advance training and extensive experience in biomedical informatics but the majority have been CRIOs for less than three years. CRIOs identify funding, data governance, and advancing data analytics as their major challenges., Conclusion: CRIOs play an important role in helping shape the future of clinical research, innovation, and data analytics in healthcare in their organizations. They share many of the same challenges and see the same opportunities for the future of the field. Better understanding the background and experience of current CRIOs can help define and develop the role in other organizations and enhance their influence in the field of research informatics.
- Published
- 2017
- Full Text
- View/download PDF
8. Core informatics competencies for clinical and translational scientists: what do our customers and collaborators need to know?
- Author
-
Valenta AL, Meagher EA, Tachinardi U, and Starren J
- Subjects
- Curriculum, Societies, Medical, United States, Certification, Education, Graduate standards, Medical Informatics standards, Professional Competence, Translational Research, Biomedical standards
- Abstract
Since the inception of the Clinical and Translational Science Award (CTSA) program in 2006, leaders in education across CTSA sites have been developing and updating core competencies for Clinical and Translational Science (CTS) trainees. By 2009, 14 competency domains, including biomedical informatics, had been identified and published. Since that time, the evolution of the CTSA program, changes in the practice of CTS, the rapid adoption of electronic health records (EHRs), the growth of biomedical informatics, the explosion of big data, and the realization that some of the competencies had proven to be difficult to apply in practice have made it clear that the competencies should be updated. This paper describes the process undertaken and puts forth a new set of competencies that has been recently endorsed by the Clinical Research Informatics Workgroup of AMIA. In addition to providing context and background for the current version of the competencies, we hope this will serve as a model for revision of competencies over time., (© The Author 2016. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
- Published
- 2016
- Full Text
- View/download PDF
9. MD-CTS: An integrated terminology reference of clinical and translational medicine.
- Author
-
Ray W, Finamore J, Rastegar-Mojarad M, Kadolph C, Ye Z, Bohne J, Xu Y, Burish D, Sondelski J, Easker M, Finnegan B, Bartkowiak B, Smith CA, Tachinardi U, Mendonca EA, Weichelt B, and Lin SM
- Abstract
New vocabularies are rapidly evolving in the literature relative to the practice of clinical medicine and translational research. To provide integrated access to new terms, we developed a mobile and desktop online reference-Marshfield Dictionary of Clinical and Translational Science (MD-CTS). It is the first public resource that comprehensively integrates Wiktionary (word definition), BioPortal (ontology), Wiki (image reference), and Medline abstract (word usage) information. MD-CTS is accessible at http://spellchecker.mfldclin.edu/. The website provides a broadened capacity for the wider clinical and translational science community to keep pace with newly emerging scientific vocabulary. An initial evaluation using 63 randomly selected biomedical words suggests that online references generally provided better coverage (73%-95%) than paper-based dictionaries (57-71%).
- Published
- 2016
- Full Text
- View/download PDF
10. Genetic data and electronic health records: a discussion of ethical, logistical and technological considerations.
- Author
-
Shoenbill K, Fost N, Tachinardi U, and Mendonca EA
- Subjects
- Humans, Medical Informatics ethics, Electronic Health Records ethics, Electronic Health Records organization & administration, Genetic Testing ethics, Genomics education, Genomics ethics, Genomics organization & administration
- Abstract
Objective: The completion of sequencing the human genome in 2003 has spurred the production and collection of genetic data at ever increasing rates. Genetic data obtained for clinical purposes, as is true for all results of clinical tests, are expected to be included in patients' medical records. With this explosion of information, questions of what, when, where and how to incorporate genetic data into electronic health records (EHRs) have reached a critical point. In order to answer these questions fully, this paper addresses the ethical, logistical and technological issues involved in incorporating these data into EHRs., Materials and Methods: This paper reviews journal articles, government documents and websites relevant to the ethics, genetics and informatics domains as they pertain to EHRs., Results and Discussion: The authors explore concerns and tasks facing health information technology (HIT) developers at the intersection of ethics, genetics, and technology as applied to EHR development., Conclusions: By ensuring the efficient and effective incorporation of genetic data into EHRs, HIT developers will play a key role in facilitating the delivery of personalized medicine.
- Published
- 2014
- Full Text
- View/download PDF
11. Integrating Governance of Research Informatics and Health Care IT Across an Enterprise: Experiences from the Trenches.
- Author
-
Embi PJ, Tachinardi U, Lussier Y, Starren J, and Silverstein J
- Abstract
Advances in health information technology and biomedical informatics have laid the groundwork for significant improvements in healthcare and biomedical research. For instance, Electronic Health Records can help improve the delivery of evidence-based care, enhance quality, and contribute to discoveries and evidence generation. Despite this promise, there are many challenges to achieving the vision and missions of our healthcare and research enterprises. Given the challenges inherent in doing so, institutions are increasingly moving to establish dedicated leadership and governance models charged with designing, deploying and leveraging various information resources to advance research and advanced care activities at AHCs. Some institutions have even created a new leadership position to oversee such activities, such as the Chief Research Information Officer. This panel will include research informatics leaders discussing their experiences from the proverbial trenches as they work to operationalize such cross-mission governance models. Panelists will start by providing an overview their respective positions and environments, discuss their experiences, and share lessons learned through their work at the intersection of clinical and translational research informatics and Health IT.
- Published
- 2013
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.