243 results on '"Stubbs, Matthew"'
Search Results
2. BIRC5 upregulation enhances DNMT3A-mutant T-ALL cell survival and pathogenesis
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Dunuwille, Wangisa, Wilson, William C., Bjeije, Hassan, Issa, Nancy, Han, Wentao, Parsons, Tyler M., Young, Andrew L., Xavier Raj, Infencia, Krishnan, Aishwarya, Gaur, Tarang, Wang, Eunice S., Weng, Andrew P., Stubbs, Matthew C., Celik, Hamza, Cashen, Amanda F., Edwards, John R., and Challen, Grant A.
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- 2024
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3. Space traffic management: Essential yet elusive?
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Stubbs, Matthew
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- 2022
4. Characterisation of Immune Thrombotic Thrombocytopenic Purpura utilising deep phenotyping and genotyping via genome wide association study
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Stubbs, Matthew James
- Abstract
Immune Thrombotic Thrombocytopenic Purpura (iTTP) is an ultra-rare, life-threatening disorder, mediated through severe ADAMTS13 deficiency causing multi-system microthrombus formation. It has specific HLA associations. We used genome-wide association studies to investigate whether iTTP patients are genetically distinct from controls. We examined two iTTP patient cohorts against controls, following standardised genome-wide quality control procedures for SNPs (>3million) and imputed HLA types. Associations were functionally investigated using expression quantitative trait loci (eQTL), motif binding prediction software, and by electrophoretic mobility shift assay (EMSA). Potential proteinprotein interactions were identified in-silico using Mast-Meme. We identified a novel locus on chromosome 3 (rs9884090, p-value of 5.22x10-10, OR0.40) associated with reduced risk of developing iTTP in the UK discovery cohort. Independent HLA signals were also detected, confirming known iTTP HLA associations. Meta-analysis,including the French replication cohort, strengthened the significance of statistical associations. The haploblock containing rs9884090 is associated with reduced POGLUT1 expression (eQTL P<0.05), and a potential causative variant (rs71767581) was identified and validated (by EMSA) within the POGLUT1 promotor. POGLUT1 in-silico modelling suggested POGLUT1 may bind ADAMTS13 TSP domains at O-glycosylation sites (TSP3:S757, TSP6:S1008, TSP7:S1027). The novel locus identified is associated with reduced risk of developing iTTP, conferring protection with an incidence of 8% of cases versus 19% in controls. Reduced POGLUT1 expression may contribute to iTTP by post-transcriptionally modifying key iTTP targets, which may include ADAMTS13, or alternative targets such as NOTCH proteins. POGLUT1 is a glycosyltransferase known to glycosylate EGF-domains, and POGLUT1 may potentially bind TSP domains within ADAMTS13, in addition to other potential targets. This work directly implicates POGLUT1 in iTTP pathophysiology.
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- 2021
5. Delayed normalization of ADAMTS13 activity in acute thrombotic thrombocytopenic purpura in the caplacizumab era
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Prasannan, Nithya, Thomas, Mari, Stubbs, Matthew, Westwood, John-Paul, de Groot, Rens, Singh, Deepak, and Scully, Marie
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- 2023
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6. Remembering James Crawford
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Laforgia, Rebecca and Stubbs, Matthew
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- 2022
7. Long-term risk of relapse in immune-mediated thrombotic thrombocytopenic purpura and the role of anti-CD20 therapy
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Doyle, Andrew J., Stubbs, Matthew J., Dutt, Tina, Lester, Will, Thomas, Will, van Veen, Joost, Hermans, Joannes, Cranfield, Tanya, Hill, Quentin A., Clark, Amanda, Bagot, Catherine, Austin, Steven, Westwood, John-Paul, Thomas, Mari, and Scully, Marie
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- 2023
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8. Supporting Law Students' Skills Development Online--A Strategy to Improve Skills and Reduce Student Stress?
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Hewitt, Anne and Stubbs, Matthew
- Abstract
Law students internationally suffer from a high level of psychological distress compared with the general and student populations, and anecdotal evidence suggests that students developing skills without adequate support experience significant stress and anxiety. This article considers an initiative at one Australian law school to develop a degree-wide structured online skills development programme as a means to both improve student skills acquisition and reduce student stress. The project implements, through the use of learning technology, the principles proposed by McKinney for making small changes to law school teaching, informed by self-efficacy theory, which can have powerful results.
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- 2017
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9. HMGA1 chromatin regulators induce transcriptional networks involved in GATA2 and proliferation during MPN progression
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Li, Liping, Kim, Jung-Hyun, Lu, Wenyan, Williams, Donna M., Kim, Joseph, Cope, Leslie, Rampal, Raajit K., Koche, Richard P., Xian, Lingling, Luo, Li Z., Vasiljevic, Marija, Matson, Daniel R., Zhao, Zhizhuang Joe, Rogers, Ophelia, Stubbs, Matthew C., Reddy, Karen, Romero, Antonio-Rodriguez, Psaila, Bethan, Spivak, Jerry L., Moliterno, Alison R., and Resar, Linda M.S.
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- 2022
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10. Real-world experience with caplacizumab in the management of acute TTP
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Dutt, Tina, Shaw, Rebecca J., Stubbs, Matthew, Yong, Jun, Bailiff, Benjamin, Cranfield, Tanya, Crowley, Maeve P., Desborough, Michael, Eyre, Toby A., Gooding, Richard, Grainger, John, Hanley, John, Haughton, Joanna, Hermans, Joannes, Hill, Quentin, Humphrey, Louise, Lowe, Gillian, Lyall, Hamish, Mohsin, Muhammad, Nicolson, Phillip L.R., Priddee, Nicole, Rampotas, Alexandros, Rayment, Rachel, Rhodes, Susan, Taylor, Alice, Thomas, William, Tomkins, Oliver, Van Veen, Joost J., Lane, Steven, Toh, Cheng-Hock, and Scully, Marie
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- 2021
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11. Parsaclisib Is a Next-Generation Phosphoinositide 3-Kinase δ Inhibitor with Reduced Hepatotoxicity and Potent Antitumor and Immunomodulatory Activities in Models of B-Cell Malignancy
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Shin, Niu, Stubbs, Matthew, Koblish, Holly, Yue, Eddy W., Soloviev, Maxim, Douty, Brent, Wang, Kathy He, Wang, Qian, Gao, Mingming, Feldman, Patricia, Yang, Gengjie, Hall, Leslie, Hansbury, Michael, O’Connor, Sybil, Leffet, Lynn, Collins, Robert, Katiyar, Kamna, He, Xin, Waeltz, Paul, Collier, Paul, Lu, Jin, Li, Yun-Long, Li, Yanlong, Liu, Phillip C.C., Burn, Timothy, Covington, Maryanne, Diamond, Sharon, Shuey, Dana, Roberts, Alan, Yeleswaram, Swamy, Hollis, Greg, Metcalf, Brian, Yao, Wenqing, Huber, Reid, Combs, Andrew, Newton, Robert, and Scherle, Peggy
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- 2020
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12. Embracing a new digital era for the 'Adelaide Law Review'
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Stubbs, Matthew
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- 2022
13. From foreign circumstances to first instance considerations : extrinsic material and the law of statutory interpretation.
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STUBBS, Matthew T
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- 2006
14. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia
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Lentaigne, Claire, Greene, Daniel, Sivapalaratnam, Suthesh, Favier, Remi, Seyres, Denis, Thys, Chantal, Grassi, Luigi, Mangles, Sarah, Sibson, Keith, Stubbs, Matthew, Burden, Frances, Bordet, Jean-Claude, Armari-Alla, Corinne, Erber, Wendy, Farrow, Samantha, Gleadall, Nicholas, Gomez, Keith, Megy, Karyn, Papadia, Sofia, Penkett, Christopher J., Sims, Matthew C., Stefanucci, Luca, Stephens, Jonathan C., Read, Randy J., Stirrups, Kathleen E., Ouwehand, Willem H., Laffan, Michael A., Frontini, Mattia, Freson, Kathleen, and Turro, Ernest
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- 2019
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15. The pan-PIM inhibitor INCB053914 displays potent synergy in combination with ruxolitinib in models of MPN
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Mazzacurati, Lucia, Collins, Robert J., Pandey, Garima, Lambert-Showers, Que T., Amin, Narmin E., Zhang, Ling, Stubbs, Matthew C., Epling-Burnette, Pearlie K., Koblish, Holly K., and Reuther, Gary W.
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- 2019
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16. Thrombotic thrombocytopenic purpura: 100 years of research on Moschcowitz syndrome
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Cataland, Spero R., Coppo, Paul, Scully, Marie, Lämmle, Bernhard, Alberio, Lorenzo, Antun, Ana, Ay, Cihan, Agosti, Pasquale, Azoulay, Elie, Baker, Ross, Benhamou, Ygal, Boechat, Tiago, Brinkkötter, Paul, Chaturvedi, Shruti, Crawley, James, De Cristofaro, Raimondo, Garma, Julio del Río, Dutt, Tina, De Groot, Rens, Rubia, Javier de la, Falter, Tanja, Farias, João, Friedman, Kenneth, Fujimura, Yoshihiro, Gavriilaki, Eleni, George, James N., Graça, Nuno A. G., Hassenpflug, Wolf-Achim, Izquierdo, Cristina Pascual, Joly-Laffargue, Bérangère, Kentouche, Karim, Knoebl, Paul, Kokame, Koichi, Hovinga, Johanna Kremer, Kühne, Lucas, Kyrle, Paul, Lester, Will, Mancini, Ilaria, Masias, Camila, Matsumoto, Masanori, Mazepa, Marshall, Miesbach, Wolfgang, Metjian, Ara, Mingot-Castellano, Maria-Eva, Miyata, Toshiyuki, Moake, Joel, Muia, Joshua, Patriquin, Chris, Pavenski, Katerina, Prohaszka, Zoltan, Peyvandi, Flora, Reti, Marienn, Rossmann, Heidi, Sakai, Kazuya, Sarode, Ravi, Schneppenheim, Reinhard, Schraner, Marissa, Singh, Deepak, Sinkovits, György, Stubbs, Matthew, Studt, Jan-Dirk, Sukumar, Senthil, Thomas, Mari, Tóth, Andor, Vanhoorelbeke, Karen, Veyradier, Agnes, Völker, Linus, Sophie von Krogh, Anne, Voorberg, Jan, Waage, Anders, Westwood, JP, Wood, Erica, Yagi, Hideo, and Zheng, X. Long
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[Display omitted]
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- 2024
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17. Organisation and delivery of a dedicated multidisciplinary prone ventilation team in the intensive care unit: Strategies and lessons from COVID-19
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Bracegirdle, Luke, primary, Stubbs, Matthew, additional, Rahman, Rezaur, additional, Jackson, Alexander I. R., additional, Burton-Papp, Helmi C., additional, Chambers, Robert, additional, Gupta, Sanjay, additional, Grocott, Michael P. W., additional, and Dushianthan, Ahilanandan, additional
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- 2023
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18. Thrombotic thrombocytopenic purpura: 100 years of research on Moschcowitz syndrome
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Alberio, Lorenzo, Antun, Ana, Ay, Cihan, Agosti, Pasquale, Azoulay, Elie, Baker, Ross, Benhamou, Ygal, Boechat, Tiago, Brinkkötter, Paul, Chaturvedi, Shruti, Crawley, James, De Cristofaro, Raimondo, Garma, Julio del Río, Dutt, Tina, De Groot, Rens, Rubia, Javier de la, Falter, Tanja, Farias, João, Friedman, Kenneth, Fujimura, Yoshihiro, Gavriilaki, Eleni, George, James N., Graça, Nuno A. G., Hassenpflug, Wolf-Achim, Izquierdo, Cristina Pascual, Joly-Laffargue, Bérangère, Kentouche, Karim, Knoebl, Paul, Kokame, Koichi, Hovinga, Johanna Kremer, Kühne, Lucas, Kyrle, Paul, Lester, Will, Mancini, Ilaria, Masias, Camila, Matsumoto, Masanori, Mazepa, Marshall, Miesbach, Wolfgang, Metjian, Ara, Mingot-Castellano, Maria-Eva, Miyata, Toshiyuki, Moake, Joel, Muia, Joshua, Patriquin, Chris, Pavenski, Katerina, Prohaszka, Zoltan, Peyvandi, Flora, Reti, Marienn, Rossmann, Heidi, Sakai, Kazuya, Sarode, Ravi, Schneppenheim, Reinhard, Schraner, Marissa, Singh, Deepak, Sinkovits, György, Stubbs, Matthew, Studt, Jan-Dirk, Sukumar, Senthil, Thomas, Mari, Tóth, Andor, Vanhoorelbeke, Karen, Veyradier, Agnes, Völker, Linus, Sophie von Krogh, Anne, Voorberg, Jan, Waage, Anders, Westwood, JP, Wood, Erica, Yagi, Hideo, Zheng, X. Long, Cataland, Spero R., Coppo, Paul, Scully, Marie, and Lämmle, Bernhard
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- 2024
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19. Cancelled operations: a 7-day cohort study of planned adult inpatient surgery in 245 UK National Health Service hospitals
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Moonesinghe, S. Ramani, Wong, Danny J.N., Harris, Steve K., Bedford, James, Boney, Oliver, Chazapis, Maria, Drake, Sharon, Farmer, Laura, Gilhooly, David, Goodwin, James, Lourtie, Jose, Wagstaff, Duncan, Grocott, Mike, Sneyd, Robert, Batchelor, Anna, Brett, Stephen, Plowright, Catherine, Shrestha, Suman, Shawyer, Richard, Ahmed, Shafi, Khondoker, Mizan, Nathanson, Mike, Cripps, Paul, Research & Audit Federation of Trainees (RAFT), Anaesthetic Audit and Research Matrix of Yorkshire (AARMY), Intensive Care & Anaesthesia Research Network of North East Trainees (INCARNNET), Merseyside Anaesthetic Group for Improving Quality (MAGIQ), Midlands East Research by Critical Care and Anaesthetic Trainees (MERCAT), North West Research and Audit Group (NWRAG), Oxford Critical Care Anaesthetic Research Enterprise (OxCCARE), Pan-London Peri-operative Audit & Research Network (PLAN), Scottish East Quality Improvement & Research Academy (SEQuoIA), SESSA Quality Improvement and Research Network (SQUARES), Severn Trainees Anaesthetic Research (STAR), South West Anaesthetic Research Matrix (SWARM), South Yorkshire Hospitals Audit and Research Collaboration (SHARC), Southcoast Peri-operative Audit and Research Collaboration (SPARC), Welsh Anaesthetic Audit Research & Engagement Network (WAAREN), West Midlands Trainee Research Anaesthesia & Intensive Care Network (WMTRAIN), Rawat, Shilpa, Sathe, Sonia, Campbell, Alison, Anandarajah, Janakan, Ball, Nicola, Bandara, Lalindra, Barnes, Dennis, Chapman, Catherine, Connor, Lynda, Cook, Amanda, Ebejer, Amanda, Evans, Samantha, Gallagher, Maire, Goff, Sarah, Halfacree, Irina, Harford, Rachel, Harris, Catherine, Jackson, Rebecca, James, Kathryn, Jones, Claire, Jones, Sharon, Malinovszky, Kathy, Mungai, Serah, Nageswaran, Hari, Perumal, Anand, Pudge, Harriet, Quinn, Leanne, Sheppard, Thomas, Smith, Trudy, Spargo, James, Storton, Sharon, Thomas, Caradog, Thomas, Charlotte, Tyrrell, Samuel, Vale, Owen, Williams, Catrin, Williams, Marie, Williams, Tom, Winfield-Young, Lewys, Worrell, Helen, Moloney, Dermot, Chuni, Chandini, Comara, Jasna, Conway, Brian, Eagle, Zara, Foster, Greg, Platt, Chris, Thorne, Alison, Hee, Wendy Lum, Armstrong, Lisa, Brennan, Albert, Burns, Justine, Busby, Chantal, Couch-Upite, Mechele, Dooks, Emma, Dunlop, Sally, Eijk, Anya, Govindaraju, Ramana, Gregory, Tamsin, Grover, Alka, Hairsine, Brigid, Hennell, Sarah, Hill, Philippa, Hollins, Thomas, Hood, Julian, Horner, Lisa, Hothersall, Helen, Ingham, Rachel, Jackson, Richard, Kitching, Amy, Kurasz, Claire, Munsie, Sarah, Nemeth, Ildiko, Paley, Carole, Premraj, Prabhakaran, Redhead, Sue, Scriven, John, Shaw, Alison, Shenton, Liz, Shiva, Hemantha, Snell, Josie, Sootheran, Lucy, Stewart, Josephine, Swinton, Frank, Totten, Claire, Varghese, Liz, Vest, Sarah, Wetherell, Ben, Hamlyn, Vincent, Tozer, James, Alce, Timothy, Bopanna, Poonam, Draper, Kevin, Emmett, Lucy, Falkner, Phillippa, Fisher, Ellie, Griffiths, Cat, Gunter, Una, Harris, Rebecca, Hashmi, Saima, Jewitt, Helen, Lodhi, Sonal, Organ, Angie, Owen, Elana, Taylor, Frances, Tritean, Maria, Wassall, Richard, Woolley, Jade, MacGregor, Mark, Atkinson, Claire, Croft, Maria, Frost, Victoria, George, Richard, Gray, Catherine, Kuttler, Anja, Lalani, Christina, Peers, Beth, Sharpe, Lisa, Skeoch, Christopher, Tarft, Hayley, Tyson, Emma, Wrigley, Martha, Qadri, Shabir, Abbas, Tahir, Barot, Niraj, Cole, Steve, Ganesh, Ritesh, Groves, Christopher, Iles, Lindsey, Petkova, Hristina, Rau, Clovis, Roberts, Jack, Shakir, Nadeem, Chaurasia, Sunil Kumar, Brown, Julia, Cunningham, Mishell, Daniels, Allison, Gannon, Emily, Haines, Annette, Johnson, Nicola, Ogle, Paul, Perumal, Srinivasan, Zeidan, Lisa, Torrance, Hew, Anwar, Sibtain, Gooneratne, Mevan, Raj, Ashok, Abbott, Tom, Ashton, Laura, Brown, Katherine, Butterfield, Emma, Fenn, Jon, Forsyth-Jones, Tim, Garth, Thomas, Gleeson, Liam, Haines, Ryan, Jacobs, Benjamin, Jyothiraj, Haren, Madhi, Shareef, Marriot, Charlotte, Martin, Rebecca, McMillan, Timothy, Menon, Arun, Mohr, Otto Ernst, Muelmenstaedt, Maria, Naeem, Hanzla, Nagendram, Myura, O'Connor, Cormac, Pang, Ching, Plummer, Kimberley, Rob, Zak, Sellers, Dan, Shaw, Michael, Smith, Christopher, Taylor, Tom, Thorat, Priya, Van Rensberg, Gerhardus, Walker, Sophie, Waqas, Farkhunda, Wicks, Peter, Wirth, Daniel, Armanious, Samuel, Allen, Kellie, Bruni, Salvatore, Burijinti Chenna, Keshava Reddy, Kaliappan, Agilan, Ocampo, Madelaine, Percuin, Adrian, Riches, Joanne, Saclot, Louie, Sevillano, Annaliza, Vertue, Mark, Knowlden, Peter, David, Beena, Gajendragadkar, Pushpaj, Gladstone, George, Hammerbeck, Henry, Iaverdino, Marina, Lilley, Carina, Linton-Willoughby, Ben, Murrell, Daniel, Patro, Shweta, Richie-Mclean, Susanna, Turnbull, Marc, Vatsala, Padmanabhan, McCourt, Killian, Black, Nick, Coary, Ciara, McCarter, Jonathan, Murphy, Alexandra, Pugh, Richard, Littler, Chris, Clements, Stephan, Bairkdar, Linda, Bennett, Gillian, Bird, Tom, Bolger, Annette, Dhar, King, Ene, Raluca, George, David, Haron, Dhania, Hobson, Lucie, Iqbal, Saba, Irvine, Lizzie, Lewis, Sion, McCallum, Roisin, O'Donovan, Benjamin, Patrick, Christopher, Perman, Christopher, Rahman, Nowfal, Roberts, Iolo, Sutcliffe, William, Towers, Tammy, Waite, Alicia, Wright, Stella, Pilsbury, Jane, Allan, Michael, Allen, Cody, Carden, Nikkita, Cotterill, Amanda, Cullis, Kerry, Eden, Daniel, Farmer, Nicola, Galloway, Andrea, Geoghegan, James, Gilani, Ahmed, Hard, Kelly, Hasan, Khalid, Horner, Christopher, Iqbal, Virginia, Lowe, Julie, Mallavalli, Ravindra, McCooty, Shanteela, McKillop, Sian, Mellers, Diane, Mukherjee, Ronan, Nicholas, Michelle, O'Hara, Chloe, Osborne, Fiona, Plunkett, Emma, Sharih, Gauhar, Westwood, John, Whapples, Annabelle, Whitehouse, Diane, Williams, Lucinda, Yasin, Bilal, Cupitt, Jason, Brown, Janette, Stoddard, Emma, Balasubramaniam, Madhu, Athanasopoulos, Paul, Bhatti, Mohammad, Blood, Laura, Buckley, Hugo, Chadwick, Julie, Cocks, Shirley, Fradkin, Deborah, Hetherington, Emily, Hill, Rebecca, Hull, Rob, Loftus, Alison, McKenna, Emma, Mcmanoman, Lucy, Milian, Lauren, Mistry, Raksha, Murthen, Lisa, Parkinson, Dave, Rhead, Kat, Sandbach, Peter, Walker, Ciara, Wheatley, Emma, Spencer, Robert, Alderson, Stephen, Bull, Christopher, Butterworth, Rachel, Cousins, Simon, Goellner, Sarah, Greasley, Mark, Lyle, Fiona, Munro, Michael, Northey, Martin, White, Stuart, Harrison, Alex, Whitney, Paul-Simon, Drake, Jeremy, Babla, Rohan, Bharti, Ash, Cole, Stephen, Crotty, Stephen, Farrow, Amy, Golhar, Anil, Indoe, Peter, Jackson, Rosada, Latif, Mariam, Leong, Melvin, Lewith, Henry, Maton-Howarth, Matthew, Millar, Victoria, Millette, Ben, Oliver, Hannah, Ralhan, Vandita, Rashid, Yasir, Rivero-Bosch, Maria, Rizvi, Sana, Saleh, Rosahn, Venkatesh, Harisg, Wilson, Kate, Nair, Ashok, Basvi, Precious, Bell, Gillian, Edwards, James, Lee, David, Luo, Guanmei, Mewies, Clare, Qureshi, Arif, Sohail, Behzad, Valap, Sachin, Hill, Stephen, Bhuwanee, Deepti, Chan, James, Dereix, John, George, Allen, Ghafoor, Tasmeen, Gold, Emma, Haigh, Daniel, Harding, David, Janardhana, Bhavia, Jayan, Jithu, King, James, Laloë, Pnt, Pearce, Lauren, Pruthi, Amit, Roscoe, Eleanor, Seharawat, Deepak, Stubbington, Mark, Vanjari, Vinayak, Venkataraman, Anantharaman, Yen, Serena, Patil, Vishal, Chan, Charles, Davenport, Garry, Featherstone, Peter, Fourie, Petrus, Hall, Christopher, Mahidik, Preeti, Masoni, Elisa, Ortu, Andrea, Patil, Anita, Pickett, Janet, Sharma, Sandeep, Goodwin, Naomi, Allen, Lucy, Anderson, Nathan, Bateson, Ethan, Bhatia, Sanchita, Churchill, Sara, Cohen, Leon, Colhoun, Patrick, Dunn, Charlotte, Durie, Carys, Elgarf, Sarah, Ferry, Jenny, Guilford, Jeremy, Halligan, Claire, Harrison, Jade, Hayes, Dominic, Holst, Ben, Hughes, Rhys, Hunt, Thomas, Jackson, John, Kohler, George, Kriger, Michael, Kulikouskaya, Svetlana, Kurani, Amit, Maden, Charlotte, Moore, Alex, Mounce, Adam, O'Donnell, Alice, Sparrow, Robert, Sutherland, Jayne, Hanison, James, Bansal, Sujesh, Greenwood, Nick, Alkholany, Mahmoud, Apple, Zoe, Asif, Anam, Bhardwaj, Neeraj, Braid, Karl, Coates, Rebecca, Czukowska, Liliana, Elliott, Lauren, Fang, Li, Greenlee, Hannah, Maria, Jashmin, Mostafa, Tarek, Patil, Amarjeet, Weigert, Andrea, Matson, Alexandra, Adamson, Christine, Barclay, Philip, Barker, Amy, Bautista, Carina, Biswas, Suman, Bull, Rhian, Carungcong, Jaime, Christoper, Fenner, Cifre, Elna, Clancy, Olivia, Friedman, Lauren, Frunza, Gabriella, Habib, Sadia, Keerthikumar, Hindusha, Kirwan, Ursula, Laycock, Helen, Leir, Sarah, Maduekwe, Victor, Martella, Carmela, Meritahti, Minna, Nundlall, Kribashnie, Oblak, Metod, Panesar, Kirat, Peters, Timothy, Pett, Eleanor, Routley, Catriona, Samani, Amee, Santhirapala, Vatsharlan, Sayan, Amrinda, Sisson, Alice, Svensson, Marie-Louise, Thankachen, Mini, Tilley, Bernadette, Topham, Charlotte, Visvendra, Sathya, Warrington, Anna, Wibberley, Helen, Spittle, Nick, Andrews, Mia, Beavis, Sarah, Bernotaitis, Daiva, Chinna, Shalini, Church, Helen, Edwards, Sian, Ford, Nicky, Hazeldine, Sarah, Hudson, James, Macey, Claire, Morgans, Matthew, Toms, Julie, Whileman, Amanda, Woodward, Jan, Wright, Stephanie, Nariani, Jaya, Clark, Sam, Duniec, Larysa, Slorach, Marc, Allan, Ashley, Burrill, Bryony, Fairless, Lynn, Francis, Nicholas, McAdam, Colin, Sheriff, Julie, McLoughlin, Thomas, Arshed, Shayan, Bird, Clare, Campbell, Debbie, Chinery, Elaine, Onya, Enoch, Perry, Ryan, Sabugueiro, Jose Miguel, Shatanda, Lydia, Sheik, Muzaffar, Jo simpson, Wong, Gabriela, Yun-Han, Chen, Wilson, Lawrence, Adshead, Duncan, Castillo, David, Faulkner, Maria, Gibson, Kim, Keogh, Tara, Michlig, Sam, Perritt, Elizabeth, Ridler, Simon, Tizzard, Kate, Troy, Anne, Rafi, Amir, Melsom, Helen, Atkinson, Vikki, Azad, Tariq, Bashliyski, Vladimir, Brown, Ellen, Clark, Sarah, Cowton, Sister Amanda, Deane, Jill, Dent, Jean, Duckett, Karin, Duncan, Louise, Hooper, Nicholas, Johnson, Tom, Kay, Andrea, Kelly, Donna, Kent, Melanie, Knight, Jo, McCarroll, Christina, Newby, Annie, Potts, Kathryn, Roe, James, Rollins, David, Sarwar, Asia, Schofield, Lewis, Skelton, Deborah, Somanath, Sameer, Taysum, Peter, Temple, Julie, Udall, William, Varin, Jane, Venyo, Lucy, Warin, Martin, Wood, Shelly, Dhileepan, Srinivasan, Saibaba, Ravishankar Jakkala, Stewart, Emma, Warwick, Eleanor, Pemberton, Omar Alex, Garmash, Maryna, Griffiths, Rhys, Hale, Suzi, Lahloub, Fatma, Lynch, Ceri, Majeed, Abbas, Patchell, Ifan, Quinton, Jennifer, Sedghi, Babak, Wallis, Stephanie, Mansoor, Sange, Belagodu, Zakaulla, Dastur, Shirin, Fuller, Bridget, Hayes, Imogen, Keshkamat, Ashwini, Monantera, Georgia, Sandhar, Roxana, Sivakumaran, Shamini, Thomas, Megan, Torne, Manish, Turner, Sherma, Wakefield, Phillipa, Rogerson, David, Addleton, Catherine, Aju, Lisha, Appleby, Marie, Barnes, Elizabeth, Boateng, Trish, Carrick, Laura, Coulborn, Elaine, Darbyshire, Rebecca, Downes, Charlotte, Fitzgerald, Jodie, Hall, Linda, Harvey, Laura, Hassan, Amr, Holding, Kathleen, Hufton, Lianne, Humphries, Louise, Humphries, Ryan, Inman, Laurence, Issit, Nicole, Longhurst, Sarah, MacGregor, Melody, Mistry, Trusha, Mohamed, Mona, Otieno, Charlene, Read, David, Scott, Michelle, Singleton, Abbie, Smith, Jill, Sohal, Aariana, Tou, Samson, Unsworth, Vanessa, Wan, Richard, Worth, Christopher, Dobson, Richard, Buckley, Rose, Codling, Rachel, Hunter, Cain, Jackson, Jenny, Lowrie, Caroline, McMillan, Catherine, McNab, Raj, Richardson, Max, Sylvester, James, Watkin, Anna, Chambers, Jonathan, Bown, Rachel, Christie, Colin, Dukes, Stephanie, Horton, Sarah, Rees, Andrew, Williams, Patricia, Williams, Sarah, Pierson, Richard, Agarwal, Nipun, Allcock, Clare, Banga, Irmeet, Baron, Kirsty, Cole, Andrea, Dalay, Santinder, Gidda, Ranjit, Lo, Phillip, Merotra, Susan, Newton, Kathryn, Riddell, Zoe, Sonksen, Julian, Jamadarkhana, Sunil, Alcock, Chanice, Allen, Wei Lin, Baker, Pearl, Beadle, Hannah, Bramall, Jon, Chiravasuta, Radu, Chohan, Amina, Christofides, Angela, Cook, Angela, Cotta, Janet, Cruz, Carina, Gilmore, Jemma, Hills, Vicky, King, Kathryn, McClelland, Lucy, Nishimura, Sei, Nyathi, Rumyana, Panagoda, Prasan, Peacock, Louise, Shinn, Emma, Spencer, Sophie, Vianzon, Mayumi, Kapoor, Ritoo, Natarajan, Nagendra, Moore, Joanna, Amoakwa-Adu, Freda, Bahlool, Sinan, Cosier, Tracey, Driscoll, Sarah, Dulea, Claudia, Feneley, Andrew, Fletcher, Marcus, Hammad, Walid, Hazelton, Tracy, Hoyland, Kim, Katyayani, Bennur, Lloyd, Catherine, Moon, Angela, Musselwhite, Janine, Nair, Ganesh, O'Donnell, Joshua, Patankar, Pushkar, Redington, Katy, Sange, Aalia, Snazelle, Mark, Srbljak, Vanja, Stead, Richard, Tariq, Ismail, Thomas, Janine, Turney, Sharon, Chukkambotla, Srikanth, Mathew, Aji, Lie, Jason, Badsha, Zackriah, Bews, Sam, Bhandari, Kumud, Cartmell, Catherine, Cox, Greg, Desai, Hawa, Doran, Mark, Duberley, Stephen, Fitchett, Jill, Forrest, Diane, Freeman, David, Gani, Asif, Gedling, Catherine, Giles, Jessica, Goddard, Wendy, Gregson, Linda, Grimes, Yvonne, Hammond, Bev, Hartley, Janice, Hudson, Gemma, Ibrahim, Ramez, Iqbal, Nasreen, Jewers, Karen, Johnston, Brian, Kakkar, Abhishek, Koczka, Istvan, Lovell, Matt, Mahmoud, Mohamad, Melvin, Cathie, Milner, Matt, Moss, Nicky, Patel, Jeet, Perry, David, Pollard, Mike, Reed, Stephanie, Rennie, Gillian, Riley, Karen, Samuels, Sherrie, Simionescu, Ioana, Sissons, Lorna, Traynor, Stephen, Tucker, Daniel, Vetuz, Glenn, Whalley, Gillian, Marshall, Philippa, Arnold, Tim, Brookes, Jamie, Cowley, Anne, Delascasas, Ruth, Edmunds, Emma, Espitalier-Noel, Dominic, Jeevananthan, Rajeev, Law, Jenni, Mintrim, Kelly, Reid, Jack, Terry, Jackie, Verma, Manish, Zahra, Jean-Paul, Thorning, Geoff, Bailes, John, Dawson, Lindsay, Donovan, Clare, Gan, Jo Han, Jeyarajah, Kaya, Selman, Andrew, Woods, Justin, Csabi, Peter, Choo, Yin Yong, Das, Saheli, Denford, Clare, Desai, Mihir, Dimber, Rahul, Ellisy, Khaled, Griffiths, Ben, Lee, Sindy, Linnett, Vanessa, Daniels, Alex, Perkin, Sadie, Ritzema, Sister Jenny, Storey, Sister Bryony, Wood, Christine, Orme, Robert, Koh, Sock, Banks, Charis, Barker, Oliver, Beames, Susan, Brown, Aislinn, Corbett, Lucy, Dalton, James, Davis, Fiona, Edmunds, Matthew, Gatfield, Will, Gerrans, Edmund, Hickish, Tom, Hignell, Emily, Hiltout, Paula, Johnston, Helen, Miller, Sam, Mullender, Jo, O'Connell, Susan, Rosedale, Kath, Samuel, Katie, Vannahme, Milena, Baigel, Gary, Grayland, Sarah, Hawley, Victoria, McAffrey, Laura, Peggler, Suzannah, Stevens, Joe, Bidd, Heena, El-Boghdadly, Kariem, Zucco, Liana, Adelaja, Yemi, Bhattacharyya, Sanjoy, Bickmore, Elsie, Body, Suzanne, May-Ling Cheung, Jenny, Chowdhury, Priaykam, Cuddihy, Joshua, Ekwere, Ndi, John-Baptiste, Ange Lise, Kelly, Paul, Leslie, Daniel, Mon, Wint, Muzengi, Natasha, Ong, Cheng, Pattni, Nisha, Potter, Thomas, Stanton, Elena, Zaky, Maryam, Partridge, Richard, Bromhead, Helen, Evans, Peter, Griffin, Denise, Kinsella, J. Joseph, Knight, Alexander, Lewis, Rosemary Anna, Lightfoot, Heidi, Martin, Jane, Mupudzi, McDonald, Nahajski, Katherine, Oladele, Segun, Ottaway, Julia, Petley, Stephen, Sheldrake, Ian, Stewart, Alexander Michael, Stokes, Aaron, Trodd, Dawn, Varsani, Nimu, Walshe, Eleanor, Brown, Caroline Wrey, Huntley, Martin, Baldry, Natalie, Bennett, Caroline, Earl, Sophie, Guy, Joyce, Peat, Maggie, Stephenson, Lorraine, Tan, Hao Ern, Wills, Louise, Yare, Michelle, Yeung, Joyce, Antrolikar, Supriya, Atterbury, Katie, Baba, Fayaz, Bancroft, Hollie, Begum, Safia, Bellamy, Mary, Couper, Keith, Evans, Lucy, Flight, Rachel, Frankling, Catriona, Ganesh, Srikant, Gresty, Joanne, Joslyn, Ruth, Kadiri, Salma, Karimi, Aalisha Mariam, Kerr, Amy, Melody, Teresa, Moore, Faye, Morrish, Jennifer, O'Sullivan, Mary, Patel, Vanisha, Reeves, Eleanor, Robley, Richard, Sampson, Julia, Sangombe, Mirriam, Shabangu, Vusumuzi, Sheppard, Lucy, Stafford, Sam, Sutton, Peter, Taylor, Joanne, Turner, James, Velho, Rochelle, Webb, Joanne, Webber, Linda, Werpachowska, Ewa, Wilkinson-Guy, Lisa, Papageorgiou, Constandinos, Bisonoothan, Sohan, Casely, Emma, Casey, Carina, Kam, Elisa, Landers, Geraldine, Pearse, Laura, Raja, Meera, Solomon, Daniel, Stoyanov, Plamen, Talati, Chiraag, Arunachalam, Hari, Ashton, Victoria, Full, Jens, Green, Samira, Gratrix, Andrew, Abernethy, Caroline, Clarke, Abigail, Desai, Pallavbhai, Martinson, Victoria, Parekh, Ravi, Phillips, Mirain, Raina, Anju, Raut, Sarah, Smales, Chris, Smith, Neil, Ugochukwu, Ruth, Willis, Matt, Ignatova, Zhana, Gill, Stuart, Agarwal, Sunita, Barclay, Harry, Campbell, Brian, Collingborn, Maggie, Dagnan, Richard, Davies, David Steven, Dhaliwal, Randeep, Dharmarathna, Ishan, Doriaswami, Yuvraj, Evans, Hywel, Foly, Ahmed, Francis, John, Green, Tim, Hassanin, Ahmed, Havalda, Peter, Huda, Ahmad, Jones, Beryl, Khoju, Ramesh, Lackmann, Maria, Mensah, Kofi, Nwaefulu, Christopher, Schmidt, Ilona, Selvraj, Gopinath, Skarbit, Norbert, Suganthi, Obla, Zeber, Jacek, Nagaratnam, Vidhya, Mukherjee, Smitangshu, Kirby, Sue, Arnold, Glenn, Bendel, Daniel, Boynton, Claire, Carvell, James, Carver, Anthony, Clayton, Matt, Desai, Keyury, Fadhlillah, Fiqry, Georgiou, Christiana, Jayakumar, Vineetha, Jeanes, Lara, Jhugursing, Mhairi, Jose, Jasmine, Karsten, Emma, Kormendy, Flora, Lewis, Stephanie, Lloyd, Dafydd, Mautadin, Francisca, McCahill, Claire, McInerney, Susan, Morland, Laura, Morsman, Elaine, Nayee, Sunny, O'Callaghan, David, Pickford, Emily, Pratap, Bhavesh, Rao, Chandana, Shah, Alka, Smith, Stephen, Smyth, Claire, Souleimanova, Icel, Templeton, Maie, Upadhyaya, Kavita, Uren, Sophie, Voralia, Shree, Wilson, Rebecca, Kushakavsky, Vlad, Ang, Justin, Beeby, Debroah, Bell, Stephanie, Boys, Helen, Brixey, Sue, Chabo, Cathleen, Cubitt, Lynsey, Dawson, Maggie, Finch, Jenny, Lewis, Robert, Purewal, Bally, Pyae, Kaung, Ramsey, Judi, Scoones, Ben, Debreceni, Gabor, Tarin, Obaid, Zondo, Nicola, Bothma, Pieter, Carmichael, Jack, Ferreira, Teresa, Goffin, Kelly, Gurung, Sarada, Kundu, Ashish, MacLennan, Sarah, Murray, Theresa, Verma, Karan, Wilson, Graeme, Winthein, Aleinmar, Jakkampudi, Satyanarayan, Ahmed, Muneeba, Baines, Duncan, Beirnes, Charmaine, Braybrook, Chrissy, Fernandez, Olga, Gracey, Jayshree, Guha, Snehasish, Jain, Arihant, Krishnaiyan, Raghavendran, Moody, Thomas, Novaga, Jo, Tait, Frances, Tate, Jemma, Taylor, Jennifer Claire, Waldron, Molly, White, Sonia, Gupta, Anish, Botfield, Claire, Ahmed, Mohamed, Ashton, Lizzie, Bailey, Andrew Robert, Banugo, Pele, Birch, Sian, Boyle, Henry, Brown, Alice, Chen, Mark, Connolly, Lucy, Dalal, Viral, Edwards, Alexandra, Elnour, Shaima, Faccini, Timothy, Floyd, Theodore, Georgiou, Thomas, Gill, James, Hedley, Russell, Hopkins, Philip, Kumar, Roshmi, Michell, Alice, O'Shaughnessy, Rhiann Marie, O'Sullivan, Laura, Pai, Seema, Parsons, Benjamin, Peltola, Laura, Penhaligan, Beth, Place, Merate, Ramsden, Jonathan, Ratnayake, Gamunu, Shammas, Kathy, Watts, Ali, Williams, Thomas, Woodham, Valantine, Puranik, Sarang, Crooks, Jennifer, Dean, Ania, Honstvet, Chris, Hunter, Katherine, Steynberg, Sarah, Swain, Andrew, Laha, Shondipon, Bonner, Alex, Doyle, Donna, Fallon, Robert, Verlander, Mark, Williams, Alexandra, Yardley, Richard, Whiteley, Simon, Ahmed, Zaid, Child, Ossian Aukland, Black, Sheila, Calderwood, Jamie, Chapman, Andy, Collin, Robert, Dwornik, Kinga, Gallagher, Kate, Gardener, Michelle, Harrop, Gareth, Hart, Peter, Howcroft, Clare, Ilyas, Carl, Kempanna, Umakanth, Krishnamurthy, Gnanshree, Kumara, Paramesh, Loh, LI Lian, Morgan, James, Pipe, Jonathan, Sathiapillai, Anand, Stones, John, Wilby, Elizabeth, Shephard, Buzz, Agarwal, Manju, Bolonenkova, Tatyana, Dunlop, Lisa, Duraisamy, Karthick, Kelly, Jenna, Nurmi, Eveliina, Patel, Mitul, Perry, Jonathan, Prior, Charles, Reece-Anthony, Rosie, Rose, Bernd Oliver, Rowland, Katie, Van Ross, Jennifer, McNamara, Helen, Permall, Natasha, Robertson, Gillian, Siew, Sarah, Smith, Amy, Spearritt, Sue, Verma, Dipali, Williams, Rhys, Zaidi, Suhail, Clayton, Samantha, Goddin, James, Joy, Stuart, Malhotra, Vikram, Mindel, Samuel, Neilson, Zoe, Wijesuria, Shanelle Tharuka, Wilkins, Ryan, Mukherjee, Kirtida, Bradley, Andrew, Coetzee, Samantha, Crook, Alexandra, Emeakaroha, Eunice, Frenkiel, Marek, Hatton, Tom, Kamraj, Kootharajan, Long, Natalie, Manikundalam, Badrinath, Peiris, Muditha, Roche, Matthew, Sandhu, Banher, White, Nichola, Woods, Annette, Yarnold, Adam, Price, Nicolas, Ashe, Marion, Disney, Tom, Dixon, Caroline, Dodds, Emily, El-Sheika, Sarah, Hameed, Yasir, Jones, Rob, Kanal, Karan, Ranaweera, Sanjeewa, Ripoll, Simon, Russell, Nicki, Smith, Sally Anne, Tung, Swee Ang, Emerson, Bruce, Apps, Victoria, Austin, Mandy, Catchpole, Laura, Catley, Christine, Child, Jenny, Cranmer, Karen, Dawson, Lizzie, Farr, Beth, Gerrish, Helen, Gibson, Sian, Gunn, Jacqueline, Holland, Kim, James, Lorri, Jayasekera, Dushyanthi, Lester, Yvonne, Lyle, Amanda, McNeela, Fiona, Oborska, Aneta, Pennington, James, Perkins, Lauren, Robinson-Perrie, Hollie, Shillito, Lauren, Singizi, Bryan, Smolen, Susan, Topliffe, Joanne, Vowles, Ben, Whybro, Natalie, Wijunamai, Amon, Willsher, Lucy, Wootton, Joanne, Varma, Sandeep, Atkinson, Philip, Buckley, Sarah, Darian, Thelma, Dhamaratne, Sachini, Gould, Richard, Graham, Laura, Hirst, Charlotte, Peeling, Andrew, Prentice, Saxon, Rajasekar, Naresh, Rose, Alastair, Smith, Craig, Wilkinson, Kate, Stewart, Richard, Chevis, Chrissie, Ekpa, John, Greig, Nurse Sara, Hinch, Nurse Rebecca, Holder, Carole, Makris, Nikolaos, Moran, Nurse Louise, Padilla Harris, Nurse Cheryl, Scarletta, Nurse Diane, Smith, Jeanette, Sara-Beth Sutherland, Nurse, Turner, Joanne, Valentine, Peter, van Manen, Amelia, Walia, Nurse Sonia, White, Nurse Charlotte, Wilson, Georgina, Wren, Nurse Lynn, Wright, Nurse Francesca, Faulds, Matthew, Agius, Claire-Marie, Ahmed, Raheel, Ahmed, Sameer, Alva, Arjun, Bird, Rachael, Buckley, David, Calder, Verity, Clark, Caroline, Craven, Emily, Cullen, Katherine, Davis, John, Diamond-Fox, Sadie, Doherty, Helen, Dutta, Bhaskar, Fortune, Jonathan, Gatehouse, Alexandra, Gibson, Jane, Hay, David, Hillier, Steve, Hindmarch, Paul, James, Michael, Keshvara, Kiran, Kotur, Karuna, Lawley, Peter, Lochanie, Nimali, Macbeth, Lisa, Madhu, Yamuna, Marcangelo, Sam, McShane, Lesley, Morgan, Amy, Mowat, Stephen, Nelson, Joshua, O'Leary, Denis, Partridge, Jennifer, Pearson, Janaki, Poulton, Tom, Prasad, Sneha, Protheroe, Kay, Qureshi, Adnaan, Rangaswamy, Girish, Richardson, Victoria, Scott, Carmen, Smallshaw, Karen, Soliman, Abdelrahman, Soulsby, Graham, Wahed, Anna, Walker, Iain, Welch, Sarah, Wilson, Jessica, Winkley, Elaine, Womack, Jonathan, Mitchell, Joellene, O'Brien, Peter, Callaghan, Debbie, Clarke, Ruth, Foggo, Graeme, Gilmour, Danielle, Hickey, Stephen, Hii, Stephanie, Livingstone, Susan, McAtear, Megan, Meehan, Sharon, Milne, Gemma, Small, James, Williams, Dewi, Jardine, Catherine, White, Graham, Wright, David, Hunter, Katie, Fleming, Gillian, Marc Hastie, P.A.-A., Hunter, Catherine, Lockhart, Jennifer, Reid, Kirsten, Robb, Hilary, Harten, Johann, Crooks, Barbara A., Ratnasabapathy, Urmila, Staber, Manfred, Pettigrew, Tom, Varveris, Daphne, Brett, Michael, Appleton, Richard, Briskoe, Michael, Brown, Graeme, Brown, Stewart, Christie, Fiona, Coady, Guy, Cowan, Richard, Drysdale, Alice, D'Sylva, Stewart, Edgar, Paul, Finnie, Graeme, Gardner, John, Gupta, Shub, Hall, Colin, Hamilton, Jane, Hunter, Laura, Ikram, Umairali, Imrie, Gregor, Kerr, Euan, Kinsella, Michael, Kommer, Maya, Lafferty, Brian, Lochrin, Christopher, Lovejoy, Tom, Loy, Maria, MacLean, Aillison, MacPherson, David, Marshall, Cara, Mawhinney, Ruth, McAteer, Claire, McCaul, Prof James, McCusker, Michael, McDowall, Katherine, McGovern, Christopher, Mckie, Stewart, Morrison, Melanie, Mulla, Suleman, Neale, Elizabeth, Niciu, Cristina, Ong, Su Ying, O'Sullivan, Finbar, Parcell, Sophie, Ramsay, Sarah, Robson, Rebecca, Roy, Nithin, Samuel, Jasmine, Scotland, Gemma, Sharma, Natasha, Slade, Kate, Soosay, Alvin, Soulsby, Charlotte, Steuart, Lois, Stevenson, Sara, Sweeney, Laura, Tan, Kerwei, Taylor, Calum, Th'ng, Francesca, Thompson, Caroline, Wardlow, James, Watson, Martin, Williams, Robin, Woodier, James, Young, Simon, Robinson, David, Howes, Jacqueline, Berwick, Scott, Boyle, Andrew, Brown, Neil, Celnik, Anna, Coleman, Alistair, Elwkhiee, Mohamed, Fernandes, Mario, Hanlon, Katie, MacLean, Sarah, Morgan, Rhian, Edgar, Jonathan, Chapman, Roddy, Razouk, Khaled, Atrah, Ali, Bhat, Sunny, Bramma, Yvonne, Campbell, Euan, Campbell, Rachel, Cormack, Anna, Dalchow, Stephan, Dodd, Ammy, Ferguson, Laura, Ferraioli, Donna, Hynd, Moyra, Janeczko, Adam, Jeffrey, Sally, Kinsey, Tony, Kummur, Yuvaraj, McIntosh, Karen, McKenna, John, Mclaughlin, Maria, Millington, Ryhs, Murphy, Emma, Parker, Kris, Reevell, Tom, Robertson, Fiona, Shankey-Smith, Will, Slorach, Colum, Szelei, Tamas, Warnock, Geoff, Watson, Stuart, Alston, Peter, Geddes, Murray, McLellan, Stuart, Allen, Eireann, Birnie, Karen, Brown, Kirsteen, Critchley, Julia, Cullen, Margaret, Eros, Alex, Forbes, Callum, French, Helen, Hall, David, Hetherington, Jonathan, Kellner, Maximiliane, Kelly, Keith, Khaled, Hiba, Mantle, Damien, McLenachan, John, Midgley, Susan, Nimmo, Susan, Ordys, Bart, Phelan, Hannah, Roddam, Philip, Shaw, Louise, Smith, Carolyn, Steel, Elizabeth, Stuart, Robert, Sturrock, John, Waite, Alasdair, Waterson, Fraser, Watson, Hannah, Wood, Elizabeth, Schraag, Stefan, Boyd, Elizabeth, Jain, Surabhi, Matthews, Elaine, Rappai, Geejo, Barr, Catriona, Stewart, Michael, Christie, Sharon, Smith, Tim, Arrow, Kate, Austin, Pauline, Chapman, Susie, Little, Jonathan, Malein, William, Sadler, Amy, Younger, Rhona, Reavley, Caroline, Allan, Katy, Ashok, Vignesh, Boroojeny, Ayda Borjian, Cutts, John-Paul, Faulds, Fiona, Fernie, Mark, Gadre, Amit, Gately, Tom, Haddon, Richard, Induruwage, Lalani, King, Siobhan, Liddle, Sian, Mallett, Paul, Mehotra, Saurabh, Ali, Inthekab Mohammed, Morris, Rachel, Nunn, David, Ferraro, Rocio Ochoa, Padhi, Pulak, Prusack, Ewa, Quak, Edmund, Singleton, Georgina, So, Kin, Stolady, Daniel, Welch, Drew, Whitear, Michael, Wilkinson, Kathy, Wu, James, Yusaf, Alex, Kakodkar, Prashant, Ghoneim, Hoda Abou, Balliston, Sara, Dudgeon, Lucy, Idris, Muna Elsheikh, Karattuparambil, Juneenath, Nanda, Lohita, Raithatha, Bhavesh, Saad, Mahmood, Spimpolo, Jenny, Titinchi, Linda, Wilson, Julie, Winstone, Ulrika, Martindale, Sarah, Cameron, Ewen, Fenner, Lynn, Hartford-Beynon, Jake, Mooney, Iain, Mundy, Charlotte, Rhidian, Rhys, Scutt, Sophie, Todd, Anna, Graham, Fiona, Ashton, Amy, Cooper, Theresa, Davidson, Katherine, Eapen, Suresh, Crowther, Hannah, Hindmoor, Claire, McSkeane, Anna, Mostafa, Mahamed, Mudimadagu, Gururaj, Rice, Polly, Wilson, Antoinette, Henry, Garry, Hollister, Nigel, Hunt, Jane, Isaac, Amanda, Morris, David, Paredes-Guerra, Antonio, Pass, Katherine, Paul, Martin, Rait, Kiran, Rousseau, Guy, Shacklock, Emma, Skinner, Amanda, Stancombe, Lucia, Thomson, Laura, Nutt, Christopher, Wright, Geoffrey, Holland, Johnny, O'Neill, Orla, Sengottaiyans, Arun, Mitra, Atideb, Garg, Sanjeev, Adams, Jonathan, Aiyedun, Temitope, Ali, Hani, Biuk, Sahar, Bond, Bryany, Cheeseman, Michelle, Clayton, Mark, Cottam, Lisa-Jayne, Dent, Kathy, Evans, Elizabeth, Evans, Sandra, Goodhand, Hannah, Green, Karen, Hatton, Jonathan, Hill, Joanne, Hutchinson, Dorothy, Jacob, Shibu, Joseph, Renjith, MacNally, Laura, Mann, Jason, McTaggart, Virginia, Newton, Maria, Pearson, Sandra, Rayet, Jaspreet, Saunders, Rebecca, Saxena, Sandeep, Venkatesh, Hemamangala, Whotton, Nikita, Ezihe-Ejiofor, Ada, Barot, Hemangini, Bridger, Hayley, Elhallous, Shady, Ghafoor, Rizana, Manhas, Vitul, Patil, Tanmay, Sadavarte, Nitin, Tharmalingam, Bhamini, Pritchard, David, Bage, Jean, Higgin, Sarah, Krishnaier, Asokan, Neilly, Esther, Rayappu, Sean, Siaw, Chye, Songaile, Ilma, Standen, Peter, Suresh, Narayanan, Weston, William, Williams, Lynne, Yuchen, Jiang, Alagar, Ravi, Taylor, Adrian, Matata, Claire, McCrossan, Roopa, Robertson, Andrew, Shekar, Priya, Stoker, Wendy, Turnbull, Elizabeth, Watkinson, Clare, Worthy, Stephen, Yates, Bryan, Ignatov, Dancho, Davies, Matthew, Abdu, Ayman, Banni, Donata, Bowyer, Helen, Brooks, David, Buhmann, Ulf, Christenssen, Victoria, Collins, James, D'Sa, Aaron, Forde, Steven, Groves, Alice, Hosahalli, Jyothi, Hunt, Lauren, Koshy, George, Lee, Robyn, Martin, Susan, McKnight, Angus, Murphy, Piers, Nash, Henry, Nkanang, Bassey, Oracki, Pamela, Pauley, Tara, Pope, Alan, Samanta, Romit, Sgardelis, Panagiotis, Stocks, Tom, Vaitheeswaran, Sivaprakash, Verma, Priya, Vrazhalska, Madlena Ivanova, Weisz, Mike, Moppett, Iain, Arunachalam, Subha, Begum, Zorba, Bhangu, Sonia, Bown, Gemma, Chana, Avninder, Chhaniyara, Puja, Constable, Natalie, Delme, Luff, Fenner, Helen, Griffith, Oliver, Hackett, Stephen, Hewson, David, Inkpin, Kristofor, Jones, Richard, Kirkdale, Richard, Lyons, Ian, Mandal, Arnab, Mehrotra, Prerna, Murphy, Martin, Pearce-Smith, Alison, Priestley, Martin, Pyke, Shirley, Rasoli, Sonia, Sharma, Suneal, Squires, Gemma, Tsim, Peter, Veitch, Jonathan, Bond-Smith, Giles, Kay, Olivia, Siviter, Richard, Allen, John, Baxter, Linden, Beer, Sally, Bernardo, Mariana, Coles, Holly, Cudlip, Jo, Devries, Talitha, Duggleby, Phil, Espinosa, Alexis, Fitzgibbon, Karina, Galente, Joao, Georgiou, Domonique, Ghosh, Soumi, Hingley, Nicholas, Kingan, Ryan, Levett, Chris, Martinez, Jose, Mattin, Alex, Moore, Anna, Morrish, Samuel, Nash, Amy, Patel, Tejuswi, Roe, Cieron, Thwaites, Victoria, Wali, Anuj, Watterson, Dafydd, Charlotte Yates, Anna Wilson, Gimenez, Marc, Boltres, Anita, McClean, Rebecca, Papadopoullos, Sam, Teh, Elena, Webb, Stephen, Brammar, Andrew, Humphreys, Joanne, Alibhai, Moiz, Alston, Daisy, Cohen, Jolyon, Coleman, Laura, Davies, Simon, Dervin, Dionne, Dooley, Rebecca, Drummond, Andrew, Findlay, Douglas, Fleming, Naomi, Hammoud, Yazzim, Hussain, Sanniah, Irwin, Katy, Javed, Asad, Kent, Linda, Lock, Lorraine, McSorland, Denise, Meadows, Alison, Mulligan, Paula, Nichols, Wendy, O'Callaghan, Maria, Ogor, Jonathan, Poole, Joanna, Ryder, Geoffrey, Shakoor, Akmal, Teo, Wei, Minto, Gary, Adshead, Stephen, Anderson, Helen, Carpenter, Adam, Clelland, Stuart, Datar, Priya, Elloway, Esme, Holl, Matt, Hulbert, Aidan, Humphreys, James, Hyams, Ben, McAleer, Sam, Newmarch, Mary, Notman, Holly, Patrick, Abigail, Perham, Anna, Pitman, Catherine, Reed, Fiona, Sampson, Paul, Smith, Hannah, Spinney, Sam, Toms, Nina, Warrener, Tim, Girgis, Michael, Barcraft-Barnes, Helena, Camsooksai, Julie, Colvin, Carolyn, Davies, Jack, Hamilton, Alex, Linton, Fiona, Nussbaum, Greg, Patch, Sarah, Simpson, Diane, Tbaily, Lee, Bain, James, A'Court, Alicja, Barr, Emma, Blethyn, Kate, Craig, Thomas, Cutler, Hugh, Davies, Jenny, Fry, Rebecca, Hawes, Elizabeth, Jenkins, Nicholas, Knight, Martin, Restall, David, Stubbs, Matthew, Sutherland, Angus, Swarbrick, Claire, Wilson, Robin, Winwright, Paul, Hamilton, Kevin, Adams, Anne, Allen, Orlanda, Boampomaa, Marilyn, Boniface, Anna-Marie, Coe, Robert, Daniel, Amelia, Finn, Joanne, Gill, Issac, Griffiths, Huw, Hackney, Joanna, Han, Ruth, Hare, Edward, Rintoul, Edward, Shpuza, Ervin, Smith, Ruth, Staines, Nikki, Suppiah, Puvan, White, Tracey, Pearson, Darcy, Cracknell, Ben, Farrell, Nadine, Hermanowski, Jane, Hodgson, Ruth, Hoskins, Toby, Jones, Rhiannon, Keable, Sam, Rosbergen, Melissa, Giles, Julian, Dawes, Thomas, Green, Ben Eden, Pottinger, Gail, Weller, Debbie, John, John, Burgess, Lisa, Denton, Jean, Done, Alaine, Edwards, Jayne, Garrett, Theresa, Gilla, Rajesh, Griffith-Norris, Samantha, Jones, Teresa, Linklater-Jones, Barbara, Nicholas, Claire, Owen, Sara, Perkins, Charlotte, Rowlands, Tessa, Steen, Julie, Turner, Sarah, Wales, Johanna, Woolley, Carol-Ann, Hormis, Anil, Collier, Dawn, Dixon, Kathryn, Gardner, Michael, Murray, Vicky, Soar, Harry, Walker, Rachel, Yaruk, Shifa, Yarwood, Daniel, Dill-Russell, Patrick, ruthy Arumugam, Bird, Georgina, Bleasby, Nichola, Chater-Lea, Peter, Craig, Emma, Davies, George, Foxton, Julie, Gilfillan, Helen, Jerram, Keelan, Kudsk-Iversen, Søren, Lee, Rebecca, Livesy, John, Mohabir, Amanda, Morris, Katherine, Raffles, Mike, Smith, Annika, Wang, Huiqi, Craig, James, Barratt, Nina, Bates, Andy, Bokor, Norbert, Cranshaw, Julius, Dominguez, Sergio, Fraine, Annette, Green, Richard, Molloy, Katie, Penny, Christina, Pitts, Sally, Purandare, Laura, Rabbi, Taslima, Serrano, Monica, Stoycheva, Tina, Vamplew, Luke, Williams, Steve, Berry, Julian, Adams, Benita, Bean, Sarah, Burt, Karen, Devooght-Johnson, Nicki, Hammonds, Fiona, Nicholls, Tom, Rowe, Michelle, Summers, Jessica, Ward, Olivia, Wroath, Belinda, Young, Gabbie, Matthews, Cathryn, Crosbie, Gearoid, Dunn, Alex, Eddy, Sara, Garcia, Lynda, Garwood, James, Green, Adam, Gupwell, Karin, Jones, Nicola, Marriott, Suzie, Masood, Mohammad, Mazzola, Francesca, McEvoy, Evanna, Ng, Yang, Park, Linda, Pauling, Stephanie, Potter, Alison, Renton, Caroline, Samways, Adam, Sibley, Pauline, Stead, Jenny, Thorpe, Kevin, Turner, Elizabeth, Walter, Michelle, Windsor, Kevin, Jha, Rajeev, Hooker, Nicolas, Kidel, Carlos, Abayalingam, Mayavan, Boulding, Richard, Coakley, Philip, Elahi, Noor, Helder, Filipe, Hilton, James, Joshi, Kunal, Kaur, Rupinder, Male, Victoria, Naji, Saqib, Pinto, Manuel, Rajendran, Yohinee, Save, Manjeet, Smith, Megan, Spence, Emily, Tang, Sophie, Urwin, Thomas, Wittenberg, Marc, Yan, Ruoling, Williams, Colin, Ardeshna, Arjun, Bamford, Peter, Hagyard, Sarah, Johnson, Patrick, McMonagle, Martina, Morris, Hayleigh, Murphy, Thomas, Papadopoulos, Stavros, Simpson, Emma, Smith-Williams, Jonathan, Vyapury, Vin, Juneja, Rohit, Black, Ethel, Eeles, Alex, Elliot, Justine, Jhanji, Shaman, Knoetze, Reynard, McCanny, Jamie, Oswald, Lauren, Roderick, Ellie, Gunning, Paul, Siddaiah, Narendra, Balachandar, Krishna, Bhimarasetty, Chandra, Bird, Laura, Blunt, Conny, Da Silva, Egidio, Darbyshire, Mark, Echaveznaguicni, Irene, Girgis, Youssef, Goodman, Martin, Gowda, Dinkar, Gowni, Rajashekar, Hayes, Melony, Jackson, Natalie, James, Anitha, Jayapal, Rekha, Jones, Claudette, Leung, Enid, Minhas, Simran, Mubarak, Mona, Muniyappa, Sudeshkumar, Nassa, Zehrin, Neal, Tom, Nyangoni, Kudakwashe, Panchakshariah, Suresh, Philpott, Bethany, Pinner, Craig, Pygall, Daniel, Rangaiah, Manamohan, Rao, Anil, Rea, William, Shellard, Richard, Shinner, Guy, Sutherland, Tony, Tharakan, Liza, Thomas, Sue, Travasso, Betty, Venkatesh, Pyda, Wortley, Dionne, Dickinson, Matthew, Benoliel, Sophie, Doyle, Nanci, Marriott, Cheryl, Martin, Sarah, Montague, Laura, Penhaligon, Kate, Saha, Rita, Santhirapala, Ramai, Suntharanathan, Lushani, Wakeford, Nichola, Webb, Carly, Winterbottom, Toby, Jordan, Lesley, Aldridge, Matt, Bolton-Hill, Clare, Cook, Prof Tim, Kangesan, Inthu, Kettley, Laura, Mew, Edward, Penketh, James, Quinn, Eleonore, Scholes, Sam, Uppugonduri, Sreekanth Rayalu, Allen, Lara, Lyndsay Bibb, Jill Brown, Busby, Charlotte, Katherine Cheshire, Davis, Matron Beryl, Denyer, Rebecca, Julie Edwards, Gardiner, Laura, Haque, Shamim, Icke, Julia, Jones, Katherine, Donna McIntosh, Mandy Oakley, Prasad, Linda, Victoria Roberts, Smallwood, Andrew, Tammy Smith, Stelfox, Lucy, Angela Stevens, Angela Willberry, Pratt, Oliver, Chincholkar, Mahindra, Darwin, Leanne, Dearden, Joy, Flowerdew, Adele, Harrison, Louise, Hartley, Robert, Ingham, Andrea, Jones, Ben, Lee, Stephanie, Longdon, Elizabeth, Marsden, Tracy, Meats, Kirsty, Michael, Angiy, Norwood-Green, Drew, O'Loughlin, Victoria, Owen, Holly, Patel, Manju, Perez, Jane, Whiston, Jessica, Wood, Andrea, Williams, Simon, Billingham, Chloe, Clarke, Caroline, Holmwood, Xantha, Knighton, Melba, Sands, Becky, Stevens, Paul, Strong-Sheldrake, Sophia, Taylor, Matthew, Rambhatla, Mrutyunjaya Rao, Brodier, Elizabeth, Choudhry, Ozerah, Choudhry, Usman, Fitzmaurice, Bethany, Hulme, Jonathan, Kannan, Santhana, Mak, Kay Anne, Namih, Miriam, Rajdev, Bharati, Rambhatla, Swetha, Reilley, Stuart, Rice, Rebecca, Sethia, Nalini, Smith, Katy, Wakhle, Rahul, Walmsley, Chris, Wrench, Ian, Agyemang, Michael, Bell, Elizabeth, Bird, Sarah, Briscoe, James, Cruickshanks, Andy, Drinkwater, Jake, Eggleston, Sam, Elms, Henry, Hammon, Laura, Harris, Meredith, Harrison, Christopher, Hirst, Claire, Housley, Kay, Kapoor, Krish, Kibutu, Faith, Kilner, Beverly, King, Emily, Kirk, Emily, Marshall, Esme, Mazzone, Paolo, Middle, Janet, Milner, Leanne, Mitchell, Adam, Morris, Becky, Mudd, Alexandra, Needham, Matthew, Nicholas, James, Penson, Rob, Perfitt, Joel, Pinkerton, Mark, Recto, Mayeth, Rehnstrom, Maria, Riley, Catherine, Ryan, Lorna, Smith, Jennie, Strong, Samantha, Thornley, Helen, Tookey, Bethany, West, Daniel, Whitaker, John, Willcock, Sarah, Willoughby, Shay, Wright, Jane, Jones, Paul, Abbott, Riquella, Bacon, Lisa, Godden, Christopher, Howe, David, Loughlin, Angela, Moore, Helen, Passey, Samuel, Rodgers, Rebekah, Foley, Paul, Hagan, Samantha, Marcus, Simon, Gardner, Irene, Haslam, Zena, Morrison, Moira, Obeysekera, Chai, Porter, Kim, Terrett, Helen, Henning, Jeremy, Baillie, Kirsty, Buchanan, Ella, Cain, Martyn, Colling, Kerry, Duarte, Raquel, Gibb, Chris, Hynd, Ryan, Irvine, Victoria, Lyons, Rob, Middleton, Karoline, Razaque, Usman, Sheikh, Faisal, Tabiner, Tariq, Frey, Christian, Brown, Carly, Clifford, Gayle, McKee, Madeleine, Stidolph, Beverley, White, Emert, Campbell, Bridget, Mason, Sophie, Parsons, Penny, Santana-Vaz, Natasha, Stagg, Camilla, Shah, Nirav, Barnes, Veronica, Bedoes, Penny, Clarke, Jonathan, Crichton, Robert, Das, Madhurima, Davies, Paul, Farrah, Helen, Hegarty, Aoife, Howlett, Luisa, Kleine-Brueggeney, Maren, Ma, Samson, Marsh, Veronica, McAndrew, Katherine, Mellinghoff, Johannes, Oscier, Christopher, Ryan, Christine, Smee, Elizabeth, Thurairasa, Dushanthi, Goel, Vandana, Adeney, Christopher, Behl, Sanjay, Chadwick, Karen, Coleman, Thomas, Davies, Claire, Dealing, Sharon, Elwood, Jamie, Fadden, Emma, Gillies, Stella, Kennedy, Tom, Miller, Thomas, Morton, Simon, Reilly, Rebecca, Smyth, Sue, Syratt, Thomas, Welfare, Emma, Thomas, Elizabeth, Awolesi, Jennifer, Bennett, Hannah, Bradshaw, Elizabeth, Crabtree, David, Duraman, Lauren, Hughes, Kerry, Kirk, Sarah, Leonard, Dee, Stoeter, Rachel, Parrington, Simon, Andorka, Matyas, Ang, Kingsin, Bailey, Linda, Brooks, Stephanie, Chiu, Oon, Collins, Sally, Jack, James, Knight, Harry, Lynn-Smith, Anastasia, Mackenzie, Matt, Maher, Sarah, Nimako, Louise, Sangaralingham, Siva, Sanusi, Seliat, Weller, Samantha, Willard, Elizabeth, Kulkarni, Anand, Carroll, Peter, Clark, Martyn, Coulding, Martina, Denman, Elizabeth, El Habishi, Mohyman, Haywood, Patrick, McConniffe, Jane, McCormick, Jacqueline, Melachuri, Krishnakar, Philip, Evelyn, Ridgway, Stephanie, Savill, Heather, Sharif, Kamal, Vere, Joanne, Harris, Stephen, Coombs, Alex, Darch, Flora, Doble, Patricia, Foot, Jayne, Gillett, Chris, Judd, Thomas, Moss, Alison, Pawley, Corinne, Tait, Moira, Whitcher, Alison, Wood, Natalie, Montgomery, Jane, De Selincourt, Gabrielle, Fitzell, Pauline, Flower, Katie, Horan, Kathleen, Hulance, Bianca, Mercer, Pauline, Shaw, Sarah, Webber, Robin, Kakkar, Manish, Joachim, Suganthi, Aggarwal, Seetal, Ali, Amr, Ang, Boon, Bhardwa, Vishnu, Deamer, Wendy, Filby, Lorna, Fletcher, Jo, Fombon, Felix, Gawley, Shannon, Gosavi, Chandrakant, Hindle, Julia, Lawrence, Tara, Maher, Robert, Moore, Samantha, Netherton, Kimberley, Orasanu, Teodora, Poimenidi, Evangelia, Potter, Louise, Ranasinghe, Niyesa, Ribeiro, Lester, Ruth, Thoy, Butler, Susie, Sutton, Tim, Thomas, Issy, Veluvolu, Divya, Walker, Thomas, Wariyapola, Charindri, Zaheer, Lail, Luoma, Valpuri, Ferguson, Catriona, Stewart, Adrienne, Bapat, Smita, Bose, Gahan, Bugo, John, Campbell, Marta, Cervi, Elizabeth, Ciechanowicz, Sarah, Coathup, Rachel, El-Wahab, Niveen, Frith, Claire, Gill, Preea, Gray, Martin, Luoma, Astri, Mehta, Sachin, Murali, Mayur, Mussad, Asya, Parker, Laura, Patch, Josh, Perella, Paolo, Robson, Emily, Setty, Thunga, Vieira, Filipe, Wall, Josh, Witby, Jon, Zghaibe, Wael, Zhang, Sheldon, Merron, Stephen, Abano, Nenette, Barnett, Loretta, Barry, Adrian, Birks, Pamela, Brade, Judith, Butler, Adrian, Carpio, Racquel, Colclough, Viv, Eaton, Katrina, Edwards, Carol, Emery, Lisa, Finney, Kay, Gallagher, Susan, Ghatge, Satyajeet, Grocott, Jeanette, Hall, Amanda, Hardwick, Alison, Harrison, Anne, Hendy, Susan, Hiden, Joanne, James, Alex, Jeganath, Vijay, Kumar, Rahul, Lord, Stephen, Lovatt, Rachel, Lyjko, Susan, Maguire, Holly, Marsden, Mia, Mehta, Venu, Mishra, Rajeev, Mittal, Rohit, Moores, Andrew, Nalwaya, Pramod, Omeara, Matthew, Orosz, Sandor, Patel, Nehal, Pattison, Nicola, Ponce, Ida, Puttapa, Ashok, Rajamanickam, Tamilselvan, Rao, Nagaraj, Remegoso, Alda, Rhodes, Rochelle, Rooney, Angela, Sadler, Emma, Singh, Permendra, Soon, Wai, Tomlins, Simon, Umbarje, Kanchan, Vallabhaneni, Murali, Varquez, Resti, Wain, Jill, White, Sorana, Willetts, Elizabeth, Williams, Benedict, Wood, Andrew, Washington, Stephen, Anipindi, Sujata, Aston, Jennifer, Bradley-Potts, Joanne, Butler, Ian, Cunningham, Jennifer, Duncan, Alastair, Garrard, Hywel, Haslam, Daniel, Kirk, Danielle, McCormick, Richard, McEvoy, Michael, Mistry, Sara, Ormandy, Danielle, Sharp, Tracy, Song, Andrew, Williamson, Georgina, Young, Francis, Tasker, Laura, Bailey, Elizabeth, Baker, Roisin, Bamford, Amy, Bergin, Colin, Blackburn, Julia, Bodo, Kinga, Carrera, Ronald, Cooper, Lauren, Despy, Liesl, Ellis, Karen, Foster, Morgan, Garner, Sharon, Harkett, Lyndon, Harkett, Samantha, Ip, Peter, Lay, Frances, Liu, Hon Sum, Mee, Laura, Nazir, Samir, Osbourne-Wylde, Jacob, Patel, Krupali, Pope, Martin, Reeves, Emma, Sahni, Melanie, Small, Charlotte, Spooner, Brendon, Spruce, Elaine, Whitehouse, Arlo, Wharton, Nicholas, Alexander, Rachel, Ashford, Amy, Aspinall, Rebecca, Bateman, Richard, Bell, Matthew, Bennett-Britton, Jennifer, Bewley, Jeremy, Blanshard, Hannah, Bourdeaux, Christopher, Brook, Peter, Cain, Helen, Cameron, Claire, Cassells, Naomi, Chauhan, Nilesh, Clarke, Adrian, Cockroft, Melanie, Cohen, Alan, Collins, Joanna, Cominos, Timothy, Craven, Rachael, Davies, Ian, Dolling, Sarah, Dowse, Claire, Driver, Kate, Duffen, Adam, Dunn, Sarah-Jane, Earnshaw, Charlotte, Forrest, Frances, Freshwater-Turner, Dan, Gardner, Issie, Gibbins, Matthew, Gibbison, Ben, Gleeson, Suzanne, Gould, Timothy, Govier, Matthew, Gupta, Benjamin, Hadfield, John, Harvey, Nicola, Henderson, Sophia, Herbert, Lara, Hillier, James, Hood, Elizabeth, Howes, Ben, Howes, Helen, Hughes, Sian, Jackson, Kathryn, Jacobs, Toby, Jenkins, Emma, Jenkins, Ian, Johnstone, Alistair, Jones, Lydia, Jones, Rebecca, Joshi, Natasha, Kamalanathan, Kajan, Kellie, Neil, Kidd, Lawrence, Kinsella, Mike (Stephen), Knight, Thomas, Leslie, Rebecca, Linter, Stephen, Lovell, Tim, Martin, Matthew, McHugh, Ursula, McIndoe, Andrew, McKendry, Rachel, Middleditch, Alexander, Miles, Edward, Milne, Lesley, Molyneux, Mat, Muchatuta, Neil, Murphy, Ruth, O'Higgins, Fran, Oglesby, Kieran, Pachucki, Marcin, Paoloni, Claudia, Patel, Nishita, Patton, Catherine (Katie), Paulich, Skylar, Pearson, Annabel, Pickering, Anthony, Platt, Martin, Pope, Charlie, Pryn, Steve, Ranjan, Amit, Rasburn, Neil, Ray, Andrew, Rivers, Jonathan, Rooney, Kieron, Ryder, Ian, Sanders, Sarah, Sasi-Kumar, Kavita, Scott, Liam, Scrutton, Mark, Searles, Chloe, Self, James, Shah, Sanjoy, Sheils, Mark, Shipway, Toby, Short, Heather, Simmonds, Lauren, Smith, Daniela, Soodan, Anjali, Steeds, Charlotte, Sweet, Katie, Syme, Phoebe, Thomas, Matthew J., Tomkins, Sally, Underwood, Susan, Wagstaff, Adrian, Watson, Paul, Webster, Denise, Welham, Katie, Whaley, Anne, Williams, Helen, Wilson, Hannah, Winton, Anoushka, Woodward, Thomas, Worthington, Jeanie, Younie, Stuart, Bradbury, Carol, Auldin, Mohammad, Bosworth, Kate, Choksey, Falguni, Dudkowsky, Bernice, Elton, John, Evans, Gail, Grove, Charlotte, Ingram, Clare, Kelly, Andrew, Lax, Peter, Lynes, Elena, Madden, George, Mistry, Vinesh, Molitor, Timothy, Morgan, Catherine, Morris, Natalie, Pallister, Emily, Patel, Pooja, Ragothaman, Vijay, Ramm, Katie, Robinson, Ben, Sharma, Meghna, Shuttleworth, Daniel, Vaidyanath, Chandrashekhar, Warren, Jen, Wong, Rachel, Lau, Gary, Conway, Hannah, Majeed, Adeel, Parmar, Jaina, Rana, Meenal, Yusuff, Hakeem, Rimmer, Corinne, Abdelrhamen, Wael, Allison, Kathryn, Burns, Karen, Cahill, Nichola, Clark, Jon, Donaldson, Hannah, Heseltine, Nick, Mackenzie, Nicola, McArthur, Carol, Moreland, Neil, Shohelly, Sharmin, Thatcher, Hilary, Tran, Steven, Walker, Catriona, Al-Rawi, Samar, Wakatsuki, Mai, Aarvold, Alice, Addy, Melissa, Ashfield, Georgina, Beauchamp, Nigel, Belcher, Alex, Bennett, Tom, Burgess, Victoria, Burton, Andy, Campbell, Matthew, Cruikshank, Ross, Cumpstey, Andy, Davies, Rhys, Ford, Chris, Ford, Renee, Hawkins, Lesley, Hendra, Tim, Huttley, Thomas, Jolly, Erica, Kalcheva, Nevena, Kennedy, Charlie, Lees, Jessica, Lowe, Richard, Martindale, Tim, McCormick, Sarah, McPhee, Hannah, Millinchamp, Fran, Muddanyake, Rahul, Osorio, Eduardo, Patel, Kiran, Pestell, Samuel, Phillips, Steve, Plumb, Jamie, Pratt, Thomas, Quartermain, Bert, Reeves, Rebecca, Robin, Sophie, Scully, Thecla, Sehgal, Anamika, Seifalan, Said, Shuttleworth, Suzanne, Siddique, Omar, Sleap, Esme, Smith, Victoria, Snooks, Richard, Solanki, Virginia, Timmons, Christina, Trimble, Alice, Tunney, Doug, Walker, Kat, Wee, Naomi, Wigley, James, Wilkins, Huw, Wong, Hanna, Wood, Laura, Yogya, Dinithi, Young, Ruth, Shanbhag, Sumant, Ameer, Farrukh, Finnity, Jonathan, Haddock, James, Hunt, Alex, Kuravi, Aditya, Lenehen, Fionnuala, McOwat, Lindsay, Naqvi, Asad, Richardson, Lisa, Siddons, Victoria, Charters, Seema, Jumani, Deepa, Bradley, Peter, Bubb, Laura, Chan, Rebekah, Connell, Lynne, Crone, Rachel, Davis, Hannah, Defeyter, Pascal, Evans, Alison, Howard, Ramdas, Prady, Helena, Rogers, Natalie, Roughley, Lindsay, Whittle, Helen, Zeinali, Daniel, Cherian, Vinanti, Latif, Muhammad Usman, Bajwa, Maqsood, Guy, Jonny, Guz, Krzysztos, Iftikhar, Nauman, Iwanicka, Beata, Khan, Mujeeb, Love, Anna-Marie, Montgomery, Celia, Mulvany, Stephen, O'Kane, Emma, O'Kane, Sinead, Siddiqui, Mansoor, Small, Cathal, Subhani, Shaik, Dana, Emily, Kennedy, Richard, Amey, Isobel, Ashton, Hilary, Baird, Yolanda, Bushell, Caroline, Chadbourn, Indra, Cohen, Merle, Finlay, Emma, Gilbert, Jeanette, Helm, David, Lewis, Carla, Macallan, Jenny, Margalef, Jordi, Martins, Nic, Metiu, Gabi, Moore, Sally, Rose, Hannah, Standley, Tom, Page, Valerie, Bakonyi, Tomas, Ben-Nathan, Simon, Claridge, Melanie, Evans, Jackie, Gardiner, Harriet, Kantsedikas, Ilya, Lachana, Ann, Makker, Ratna, Markwell, Karen, Merrill, Colin, Mukerjee, Prasun, O'Donohoe, Lynn, Oglesby, Fiona, Osbourne, Laura, Parker, Beena, Passaro, Emelia, Russell, Katherine, Shah, Sneh, Sundayi, Saul, Walker, Elaine, Zhao, Xiao, Hosdurga, Guru, Cotterill, Donna, Crowther, Nicola, Dymond, Harvey, Ratcliffe-Law, Thomas, Saunders, Glenn, Saunders, Thomas, Gopal, Vijayakumar, Ahmed, Sajjad, Ali, Abdalla, Crawford, Sarah, De'Ath, Clare, Humphreys, Sally, Swanevelder, Carin, Yap, Yeng, Silk, Jane, Adeniba, Rashidat, Armstrong, Richard, Egole, Osi, Fan, Karen, Gilbert, Kayleigh, Gould, Laura, Hickman, John, Long, Fei, Pahary, Sheik, Reichman, Michelle, Simpson, Kathryn, Singaravelu, Suresh, Ahmed, Dabeeruddeen, Brailsford, Fiona, Bridge, Laura, Collis, Lauren, Jacob, Reni, Jones, Cathy, Kirrage, Amanda, Lowe, Jessica, Mullen, Joanne, Prenter, Andrew, Sarao, Sarbpreet, Sharpley, David, Wankhade, Kavita, Persad, Cindy, Burtenshaw, Andrew, Blyth, Kate, Corcoran, Felicity, Davis, Caroline, Dolan, Rachel, Hussain, Nageena, Pearson, Emma, Pierson, Anna, Poyntz, Victoria, Thrush, Jessica, Wollaston, Alex, Wollaston, Julie, Clements, Paul, Biswas, Arindam, Clayton, Sarah, Clayton, Thomas, Cochrane, Naomi, Duell, Kirsty, Evans, James, Gaskell, Mark, Heaton, Dianne, Heaton, Linzi, Hill, Claire, Killen, Ruth, Latham, Sandra, McIntosh, Gemma, Moore, Chris, Parkinson, Val, Pemberton, Nicola, Robinson, Matthew, Sawyer, Alastair, Sykes, Isabelle, Taylor, Tracey, Tierney, Caroline, van de Snepscheut-Jones, Katja, Wade, Emily, Wahid, Mohammed, Wang, Henry, Williams, Claire, Wu, Dominic, Yadagiri, Manjula, Zabauski, Dmitry, Troth, Laura, Andrews, Eleanor, Bains, Ranjit, Beard, Laura, Birch, Janine, Britton, Rachael, Salmon, Mike, Vassell, Elizabeth, Kubisz-Pudelko, Agnieszka, Allen, Jamie, Allison, Joanna, Baird, Andrew, Gregory, Rob, Luckhurst, Hannah, Mairs, Rebecca, Marshall, Ben, Pippard, Lucy, Pitt-Kerby, Tressy, Savva, Andrew, Walkden, Graham, Weegenaar, Celly, Chandler, Ben, Kanakaraj, Muthuraj, Chamberlain, Andy, Dyer, Simon, Elliott, Kerry, Forshaw, Greg, Furness, Rosie, Gibson, Andy, Howe, Laura, Kent, Sarah, Rodgers, Alicia, Straughan, Ben, Temlett, Emma, Whitwell, John, Wong, D.J.N., Harris, S.K., and Moonesinghe, S.R.
- Published
- 2018
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20. The 'Adelaide Law Review' at (volume) 40: Reflections and future directions
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Stubbs, Matthew
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- 2019
21. Dale Stephens and Matthew Stubbs
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Stephens, Dale and Stubbs, Matthew
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- 2019
22. Law, war, ethics and conscience: An enduring conundrum
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Stephens, Dale and Stubbs, Matthew
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- 2019
23. Superior efficacy of co-targeting GFI1/KDM1A and BRD4 against AML and post-MPN secondary AML cells
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Fiskus, Warren, Mill, Christopher P., Nabet, Behnam, Perera, Dimuthu, Birdwell, Christine, Manshouri, Taghi, Lara, Bernardo, Kadia, Tapan M., DiNardo, Courtney, Takahashi, Koichi, Daver, Naval, Bose, Prithviraj, Masarova, Lucia, Pemmaraju, Naveen, Kornblau, Steven, Borthakur, Gautam, Montalban-Bravo, Guillermo, Manero, Guillermo Garcia, Sharma, Sunil, Stubbs, Matthew, Su, Xiaoping, Green, Michael R., Coarfa, Cristian, Verstovsek, Srdan, Khoury, Joseph D., Vakoc, Christopher R., and Bhalla, Kapil N.
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- 2021
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24. Substantive recognition of Aboriginal and Torres Strait Islander peoples in the Constitution.
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STUBBS, Matthew
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- 2016
25. Abstract CT243: Clinical trial simulation to inform dose selection of zilurgisertib, an ALK2 inhibitor, in patients with anemia due to myelofibrosis (MF)
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Yang, Yan-ou, primary, Yang, Hong, additional, Lamothe, Betty, additional, Stubbs, Matthew, additional, McBride, Amanda, additional, Seguy, Francis, additional, Rockich, Kevin, additional, Getsy, Jay, additional, Wang, Phillip, additional, Liu, Xiang, additional, Jackson, Jeff, additional, Asatiani, Ekaterine, additional, and Chen, Xuejun, additional
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- 2023
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26. Abstract 5162: Discovery of INCB098377: a potent inhibitor of phosphoinositide 3-kinase gamma (PI3Kγ)
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Arias, Diana A., primary, Douglass, Stephen, additional, Truong, Lisa, additional, Wang, Qian, additional, Wang, Kathy H., additional, Yang, Gengjie, additional, Hansbury, Michael, additional, O’Connor, Sybil, additional, Bowman, Kevin, additional, Collins, Robert, additional, Stubbs, Matthew, additional, Hall, Leslie, additional, Stevens, Christina, additional, Maddage, Christopher, additional, Douty, Brent, additional, Covington, Maryanne, additional, Leffet, Lynn, additional, Yue, Eddy, additional, Combs, Andrew, additional, Kim, Sunkyu, additional, Shin, Niu, additional, Koblish, Holly, additional, and Hess, Rodrigo, additional
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- 2023
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27. Mobile Phone Voting for Participation and Engagement in a Large Compulsory Law Course
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Habel, Chad and Stubbs, Matthew
- Abstract
This article reports on an action-research project designed to investigate the effect of a technological intervention on the complex interactions between student engagement, participation, attendance and preparation in a large lecture delivered as part of a compulsory first-year law course, a discipline which has not been the focus of any previous study. The technology used was VotApedia, a form of mobile phone voting, and it was implemented in tandem with constructivist pedagogies such as explicit pre-reading and a prior context of interactive lecturing. Data were collected through observation, via mobile phone voting in class and by an online survey designed to specifically explore the relationship between attendance at VotApedia lectures and factors such as self-reported engagement, attendance and preparation. The findings indicated that student response systems (SRSs) are just as applicable to more Humanities-style disciplines which require divergent questioning, and supported complex interactions between engagement, attendance and preparation. Preliminary findings indicated that, although more work needs to be done, especially on the types of students who prefer to use these systems, there is a clear potential to increase student engagement in large law lectures through the use of SRSs.
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- 2014
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28. Lactate Utilization Provides a Metabolic Escape to Resist the Antileukemic Activity of BET Inhibition in Acute Myeloid Leukemia
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Monteith, Andrew J., primary, Ramsey, Haley E., additional, Greenwood, Dalton, additional, Arrate, Maria P., additional, Fuller, Londa, additional, Gorska, Agnieszka E., additional, Silver, Alexander J., additional, Brown, Donovan J., additional, Olmstead, Sarah D., additional, Watke, Jackson, additional, Stubbs, Matthew J., additional, Rathmell, Jeffrey C., additional, and Savona, Michael R., additional
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- 2022
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29. The Acquisition of Indigenous Property on Just Terms: Wurridjal v Commonwealth
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Stubbs, Matthew T
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- 2011
30. Prosper the Government, Suffer the Practitioner: The Graham Barclay Oysters Litigation
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Stubbs, Matthew
- Published
- 2003
31. Adrenal haemorrhage and infarction in the setting of vaccine-induced immune thrombocytopenia and thrombosis after SARS-CoV-2 (Oxford–AstraZeneca) vaccination
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Graf, Anneke, primary, Armeni, Eleni, additional, Dickinson, Louise, additional, Stubbs, Matthew, additional, Craven, Brian, additional, Srirangalingam, Umasuthan, additional, and Chung, Teng-Teng, additional
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- 2022
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32. Dengue fever in returning travellers
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Bain, Barbara J and Stubbs, Matthew J
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- 2015
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33. HOXA9 is required for survival in human MLL-rearranged acute leukemias
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Faber, Joerg, Krivtsov, Andrei V., Stubbs, Matthew C., Wright, Renee, Davis, Tina N., van den Heuvel-Eibrink, Marry, Zwaan, Christian M., Kung, Andrew L., and Armstrong, Scott A.
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- 2009
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34. HMGA1 Chromatin Regulators Drive Progression in Myeloproliferative Neoplasms through Epigenetic Rewiring to Induce Networks Involved in GATA2 and Proliferation
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Li, Liping, primary, Kim, Jung-Hyun, additional, Lu, Wenyan, additional, Cope, Leslie, additional, Williams, Donna M, additional, Kim, Joseph, additional, Rampal, Raajit, additional, Koche, Richard, additional, Xian, Lingling, additional, Luo, Li, additional, Vasiljevic, Marija, additional, Matson, Daniel R, additional, Zhao, Zhizhuang Joe, additional, Rogers, Ophelia, additional, Stubbs, Matthew C., additional, Reddy, Karen, additional, Spivak, Jerry L., additional, Moliterno, Alison R., additional, and Resar, Linda, additional
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- 2021
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35. Vaccine-induced immune thrombocytopenia and thrombosis associated anterior ST-elevation myocardial infarction
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Henry, John A, primary, Chen, Daniel H, additional, Stubbs, Matthew J, additional, Bhattacharyya, Sanjeev, additional, and Khanji, Mohammed Y, additional
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- 2021
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36. Identification of a homozygous recessive variant in PTGS1 resulting in a congenital aspirin-like defect in platelet function
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Chan, Melissa, Hayman, Melissa A, Sivapalaratnam, Suthesh, Crescente, Marilena, Allan, Harriet E, Edin, Matthew L, Zeldin, Darryl C, Milne, Ginger L, Stephens, Jonathan, Greene, Daniel, Hanif, Moghees, O'Donnell, Valerie B, Dong, Liang, Malkowski, Michael G, Lentaigne, Claire, Wedderburn, Katherine, Stubbs, Matthew, Downes, Kate, Ouwehand, Willem H, Turro, Ernest, Hart, Daniel P, Freson, Kathleen, Laffan, Michael A, and Warner, Timothy D
- Subjects
Platelets ,platelet dysfunction ,cyclo-oxygenase ,Disorders of Platelet Function ,genetics - Abstract
We have identified a rare missense variant on chromosome 9, position 125145990 (GRCh37), in exon 8 in PTGS1 (the gene encoding cyclo-oxygenase 1, COX-1, the target of anti-thrombotic aspirin therapy). We report that in the homozygous state within a large consanguineous family this variant is associated with a bleeding phenotype and alterations in platelet reactivity and eicosanoid production. Western blotting and confocal imaging demonstrated that COX-1 was absent in the platelets of three family members homozygous for the PTGS1 variant but present in their leukocytes. Platelet reactivity, as assessed by aggregometry, lumi-aggregometry and flow cytometry, was impaired in homozygous family members, as were platelet adhesion and spreading. The productions of COX-derived eicosanoids by stimulated platelets were greatly reduced but there were no changes in the levels of urinary metabolites of COX-derived eicosanoids. The proband exhibited additional defects in platelet aggregation and spreading which may explain why her bleeding phenotype was slightly more severe than those of other homozygous affected relatives. This is the first demonstration in humans of the specific loss of platelet COX-1 activity and provides insight into its consequences for platelet function and eicosanoid metabolism. Notably despite the absence of thromboxane A2 (TXA2) formation by platelets, urinary TXA2 metabolites were in the normal range indicating these cannot be assumed as markers of in vivo platelet function. Results from this study are important benchmarks for the effects of aspirin upon platelet COX-1, platelet function and eicosanoid production as they define selective platelet COX-1 ablation within humans. ispartof: HAEMATOLOGICA vol:106 issue:5 pages:1423-1432 ispartof: location:Italy status: published
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- 2021
37. Caplacizumab Frontline Added to Therapeutic Plasma Exchange and Immunosuppression Prevents Unfavorable Outcomes in Immune-Mediated TTP: An International Real-World Study of the TTP-IWG (The Capla 500 Project)
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Coppo, PAUL, Bubenheim, Michaël, Benhamou, Ygal, Voelker, Linus A., Brinkkoetter, Paul T., Kühne, Lucas, Knoebl, Paul N., Mingot, Maria Eva, Pascual Izquierdo, Maria Cristina, De La Rubia, Javier, Del Rio Garma, Julio, Chaturvedi, Shruti, Masias, Camila, Mazepa, Marshall, Zheng, X. Long, Sinkovits, Gyorgy, Reti, Marienn, Patriquin, Christopher J., Pavenski, Katerina, Boechat, Tiago, Farias, Joao, Ribeiro, Eduardo Flavio Oliveira, de Andrade, Michaela Larissa Lobo, Veyradier, Agnès, Joly, Bérangère, Sr., Bouzid, Raïda, Sakai, Kazuya, Matsumoto, Masanori, Mancini, Ilaria, Agosti, Pasquale, Peyvandi, Flora, Stubbs, Matthew James, Hmaid, Amjad, Sharif, Sobia, Dutt, Tina, Cataland, Spero, Lammle, Bernhard, and Scully, Marie
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- 2023
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38. ALK2 and JAK2 Inhibition for Improved Treatment of Anemia in Myelofibrosis Patients: Preclinical Profile of an ALK2 Inhibitor Zilurgisertib in Combination with Ruxolitinib
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Stubbs, Matthew C., Pusey, Michelle, Wen, Xiaoming, Drake, Katherine, Zolotarjova, Nina, Smith, Amanda, Covington, Maryanne, Zhang, Guofeng, Macarrón, Ricardo, and Kim, Sunkyu
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- 2023
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39. Preclinical Evaluation of INCB160058 - a Novel and Potentially Disease-Modifying Therapy for JAK2V617F Mutant Myeloproliferative Neoplasms
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Stubbs, Matthew C., Celik, Hamza, Ai, Yanran, He, Xin, Chang, Hong, Lei, Angela, Rupar, Mark, Wass, Brittney, Diamond, Melody, Wen, Xiaoming, Li, Jun, Zolotarjova, Nina, Margulis, Alex, Trivedi, Gaurang, Laranjeira, Angelo B.A., Taylor, Cooper A., Rocha, Jennifer, Pollmann, Christoph, Piehler, Jacob, Ferreira, Bianca L., Hitchcock, Ian, Macarrón, Ricardo, Yue, Eddy W., and Kim, Sunkyu
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- 2023
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40. Publisher Correction:Whole-genome sequencing of a sporadic primary immunodeficiency cohort (Nature, (2020), 583, 7814, (90-95), 10.1038/s41586-020-2265-1)
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Thaventhiran, James E.D., Lango Allen, Hana, Burren, Oliver S., Rae, William, Greene, Daniel, Staples, Emily, Zhang, Zinan, Farmery, James H.R., Simeoni, Ilenia, Rivers, Elizabeth, Maimaris, Jesmeen, Penkett, Christopher J., Stephens, Jonathan, Deevi, Sri V.V., Sanchis-Juan, Alba, Gleadall, Nicholas S., Thomas, Moira J., Sargur, Ravishankar B., Gordins, Pavels, Baxendale, Helen E., Brown, Matthew, Tuijnenburg, Paul, Worth, Austen, Hanson, Steven, Linger, Rachel J., Buckland, Matthew S., Rayner-Matthews, Paula J., Gilmour, Kimberly C., Samarghitean, Crina, Seneviratne, Suranjith L., Sansom, David M., Lynch, Andy G., Megy, Karyn, Ellinghaus, Eva, Ellinghaus, David, Jorgensen, Silje F., Karlsen, Tom H., Stirrups, Kathleen E., Cutler, Antony J., Kumararatne, Dinakantha S., Chandra, Anita, Edgar, J. David M., Herwadkar, Archana, Cooper, Nichola, Grigoriadou, Sofia, Huissoon, Aarnoud P., Goddard, Sarah, Jolles, Stephen, Schuetz, Catharina, Boschann, Felix, Abbs, Stephen, Adhya, Zoe, Adlard, Julian, Afzal, Maryam, Ahmed, Irshad, Ahmed, Munaza, Ahmed, Saeed, Aitman, Timothy J., Alachkar, Hana, Alamelu, Jayanthi, Alikhan, Raza, Allen, Carl E., Allen, Louise, Allsup, David J., Alvi, Arif, Ambegaonkar, Gautam, Anantharachagan, Ariharan, Ancliff, Philip, Anderson, Julie, Antrobus, Richard, Armstrong, Ruth, Arno, Gavin, Arumugakani, Gururaj, Arya, Rita, Ashford, Sofie, Astle, William J., Attwood, Anthony, Austin, Steve, Aydinok, Yesim, Ayub, Waqar, Babbs, Christian, Bacchelli, Chiara, Baglin, Trevor, Bakchoul, Tamam, Bariana, Tadbir K., Barratt, Jonathan, Barwell, Julian, Baski, John, Bates, Rachel W., Batista, Joana, Baynam, Gareth, Bennett, David L., Bethune, Claire, Bhatnagar, Neha, Bibi, Shahnaz, Bierzynska, Agnieszka, Biss, Tina, Bitner-Glindzicz, Maria A.K., Bleda, Marta, Blesneac, Iulia, Boardman, Barbara, Boddana, Preetham, Bogaard, Harm J., Booth, Claire, Boyce, Sara, Bradley, John R., Brady, Angela, Breen, Gerome, Brennan, Paul, Brewer, Carole, Briley, Annette, Brown, Richard, Browning, Michael J., Brownlie, Mary, Bryson, Christine J., Buchan, Rachel J., Buck, Jackie, Bueser, Teofila, Diz, Carmen Bugarin, Burns, Siobhan O., Calleja, Paul, Carmichael, Jenny, Carr-White, Gerald, Carss, Keren J., Casey, Ruth, Chalmers, Elizabeth, Chambers, Jenny, Chambers, John, Chan, Melanie M.Y., Chan, Melissa V., Cheng, Floria, Chinn, Ivan K., Chinnery, Patrick F., Chitre, Manali, Chong, Sam, Christian, Martin T., Church, Colin, Clement, Emma M., Brod, Naomi Clements, Clifford, Hayley, Clowes, Virginia E., Coghlan, Gerry, Colby, Elizabeth, Cole, Trevor R.P., Collins, Janine H., Collins, Peter W., Condliffe, Robin, Cook, H. Terence, Cook, Stuart, Cookson, Victoria, Corris, Paul A., Creaser-Myers, Amanda, Crisp-Hihn, Abigail, Curry, Nicola S., Da Costa, Rosa, Danesino, Cesare, Daniels, Matthew J., Darby, Damaris, Daugherty, Louise C., Davies, E. G., Davies, Sophie, Davis, John, de Bree, Godelieve J., Deacock, Sarah, Deegan, Patrick B., Dempster, John, Dent, Timothy, Deshpande, Charu, Devlin, Lisa A., Dewhurst, Eleanor F., Dixit, Anand K., Dixon, Peter H., Doffinger, Rainer, Dolling, Helen, Dormand, Natalie, Downes, Kate, Drazyk, Anna M., Drewe, Elizabeth, Duarte, Daniel, Dutt, Tina, Edwards, Karen E., Egner, William, Ekani, Melanie N., El-Shanawany, Tariq, Elkhalifa, Shuayb, Elston, Tony, Emmerson, Ingrid, Erber, Wendy N., Erwood, Marie, Estiu, Maria C., Evans, Dafydd Gareth, Evans, Gillian, Everington, Tamara, Eyries, Mélanie, Favier, Remi, Firth, Helen V., Fitzpatrick, Maggie M., Fletcher, Debra, Flinter, Frances A., Fox, James C., Frary, Amy J., French, Courtney E., Freson, Kathleen, Frontini, Mattia, Furie, Bruce, Gale, Daniel P., Gall, Henning J., Gardham, Alice, Gaspar, H. Bobby, Gattens, Michael, Ghali, Neeti, Ghataorhe, Pavandeep K., Ghio, Stefano, Ghofrani, Hossein Ardeschir, Ghurye, Rohit, Gibbs, J. Simon R., Gilbert, Rodney D., Girerd, Barbara, Girling, Joanna C., Gissen, Paul, Gorman, Kathleen M., Gosal, David, Graf, Stefan, Grassi, Luigi, Greenhalgh, Alan J., Greenhalgh, Lynn, Greinacher, Andreas, Gresele, Paolo, Griffiths, Philip G., Griffiths, Sian, Grozeva, Detelina, Hackett, Scott J., Hadden, Robert D.M., Hadinnapola, Charaka, Hague, Rosie, Hague, William M., Haimel, Matthias, Hall, Matthew, Halmagyi, Csaba, Hammerton, Tracey, Hanson, Helen L., Harkness, Kirsty, Harper, Andrew R., Harper, Lorraine, Harris, Claire, Harrison, Claire, Hart, Daniel, Hassan, Ahamad, Hayman, Grant, Heemskerk, Johan W.M., Hegde, Shivaram, Henderson, Alex, Henderson, Robert H., Hensiek, Anke, Henskens, Yvonne M.C., Hodgson, Joshua, Hoffman, Jonathan, Holden, Simon, Holder, Muriel, Horvath, Rita, Houlden, Henry, Houweling, Arjan C., Howard, Luke S., Hu, Fengyuan, Hudson, Gavin, Hughes, Sean, Hughes, Stephen, Huis in ‘t Veld, Anna E., Humbert, Marc, Hurles, Matthew E., Hurst, Jane A., Irvine, Val, Izatt, Louise, James, Roger, Jeevaratnam, Praveen, Johnson, Mark, Johnson, Sally A., Jolley, Jennifer D., Jones, Bryony, Jones, Julie, Josifova, Dragana, Jurkute, Neringa, Karim, Yousuf M., Karoshi, Mahantesh A., Kasanicki, Mary A., Kazkaz, Hanadi, Kazmi, Rashid, Keeling, David, Kelleher, Peter, Kelly, Anne M., Kempster, Carly, Kennedy, Fiona, Kiani, Sorena, Kiely, David G., Kingston, Nathalie, Kinsey, Sally, Klein, Nigel, Klima, Robert, Knox, Ellen, Kostadima, Myrto A., Kovacs, Gabor, Koziell, Ania B., Kreuzhuber, Roman, Krishnakumar, Deepa, Kuijpers, Taco W., Kumar, Ajith, Kurian, Manju A., Laffan, James, Laffan, Michael A., Lalloo, Fiona, Lambert, Michele P., Lawman, Sarah H.A., Lawrie, Allan, Layton, D. Mark, Lear, Sara E., Lees, Melissa M., Lentaigne, Claire, Levine, Adam P., Lewington, Andrew J.P., Li, Wei, Liesner, Ri, Liu, Bin, Longhurst, Hilary, Lorenzo, Lorena E., Louka, Eleni, Hadeler, Silvia Lucato, Lyons, Paul A., Macdougall, Malcolm, Machado, Rajiv D., MacKenzie Ross, Robert V., Mackillop, Lucy H., MacLaren, Robert, Madan, Bella, Magee, Laura, Mahdi-Rogers, Mohamed, Maher, Eamonn R., Makris, Mike, Mangles, Sarah, Manson, Ania, Manzur, Adnan, Mapeta, Rutendo, Marchbank, Kevin J., Mark, Patrick B., Marks, Stephen, Markus, Hugh S., Marschall, Hanns Ulrich, Marshall, Andrew, Martin, Jennifer M., Masati, Larahmie, Mathias, Mary, Matser, Vera, Matthews, Emma L., Maw, Anna, Maxwell, Heather, McAlinden, Paul, McCarthy, Mark I., McDermott, Elizabeth M., McGowan, Simon J., McJannet, Coleen, McKinney, Harriet, Meacham, Stuart, Mead, Adam J., Castello, Ignacio Medina, Meehan, Sharon, Mehta, Sarju, Mercer, Catherine L., Michaelides, Michel, Michell, Anna C., Milford, David, Millar, Carolyn M., Millar, Hazel, Mistry, Anoop, Moenen, Floor, Moledina, Shahin, Montani, David, Moore, Anthony T., Moore, Jason, Morrell, Nicholas W., Morrisson, Valerie, Mozere, Monika, Muir, Keith W., Mumford, Andrew D., Murng, Sai H.K., Nasir, Iman, Nejentsev, Sergey, Newnham, Michael, Ng, Joanne, Ngoh, Adeline, Noorani, Sadia, Noori, Muna, Nurden, Paquita, O’Sullivan, Jennifer M., Obaji, Samya, Okoli, Steven, Oksenhendler, Eric, Olschewski, Andrea, Olschewski, Horst, Ong, Albert C.M., Ong, Kai Ren, Oram, Helen, Ormondroyd, Elizabeth, Othman, Shokri, Ouwehand, Willem H., Pantazis, Antonis, Papadia, Sofia, Papandreou, Apostolos, Park, Soo Mi, Parker, Alasdair P.J., Parry, David, Parsons, Georgina, Pasi, K. John, Paterson, Joan, Payne, Jeanette H., Peacock, Andrew J., Peerlinck, Kathelijne, Pepke-Zaba, Joanna, Perry, David, Petersen, Romina, Piechowski-Jozwiak, Bartlomiej, Pinto, Fernando, Polwarth, Gary J., Ponsford, Mark J., Prasad, Sanjay, Prokopenko, Inga, Psaila, Beth, Pyle, Angela, Qasim, Waseem, Quinn, Ellen, Quinti, Isabella, Raina, Sanjay, Ranganathan, Lavanya, Rankin, Julia, Rankin, Stuart, Rao, Anupama, Raymond, F. Lucy, Rehnstrom, Karola, Reid, Evan, Reilly, Mary M., Renton, Tara, Revel-Vilk, Shoshana, Rhodes, Christopher J., Rice, Andrew S.C., Richards, Emma E., Richards, Mike, Richardson, Sylvia, Richter, Alex, Robert, Leema, Roberts, Irene, Rondina, Matthew T., Rosser, Elisabeth, Rothwell, Peter, Roughley, Catherine, Roy, Noemi B., Rue-Albrecht, Kevin, Sadeghi-Alavijeh, Omid, Saleem, Moin A., Salmon, Richard M., Samani, Nilesh J., Sambrook, Jennifer G., Sandford, Richard, Santra, Saikat, Satchell, Simon C., Savic, Sinisa, Scelsi, Laura, Schotte, Gwen, Schulman, Sol, Schulze, Harald, Scott, Richard, Scully, Marie, Searle, Claire, Seeger, Werner, Sewell, W. A.Carrock, Seyres, Denis, Shackley, Fiona, Shamardina, Olga, Shapiro, Susan E., Sharma, Pankaj, Shehata, Hassan A., Shipley, Deborah, Shtoyerman, Rakefet, Sibson, Keith, Side, Lucy, Simpson, Michael, Sims, Matthew C., Sinha, Manish D., Sivapalaratnam, Suthesh, Skytte, Anne Bine, Smith, Kenneth G.C., Snape, Katie, Sneddon, Linda, Sohal, Aman, Soubrier, Florent, Southgate, Laura, Southwood, Mark, Splitt, Miranda, Staines, Simon, Stark, Hannah, Stauss, Hans, Steele, Cathal L., Stein, Daniel, Stein, Penelope E., Stock, Sophie, Stubbs, Matthew J., Suntharalingam, Jay, Swietlik, Emilia M., Symington, Emily, Tait, R. Campbell, Talks, Kate, Tan, Rhea Y.Y., Taylor, Gordon B., Thachil, Jecko, Themistocleous, Andreas C., Thomas, David C., Thomas, Ellen, Thomas, Patrick, Thompson, Dorothy A., Thomson, Kate, Thrasher, Adrian J., Thys, Chantal, Tilly, Tobias, Tischkowitz, Marc, Titterton, Catherine, Todd, John A., Toh, Cheng Hock, Tool, Anton T.J., Toshner, Mark R., Traylor, Matthew, Treacy, Carmen M., Treadaway, Paul, Trembath, Richard C., Trippier, Sarah, Tuna, Salih, Turek, Wojciech, Turro, Ernest, Upton, Paul D., Urniaz, Rafal, Vale, Tom, Van Geet, Chris, van Zuydam, Natalie, Vandersteen, Anthony M., Vazquez-Lopez, Marta, Veltman, Marijcke W.M., Vogt, Julie, von Ziegenweidt, Julie, Noordegraaf, Anton Vonk, Vora, Ajay, Vries, Minka J.A., Wakeling, Emma L., Walker, Neil, Walker, Suellen M., Walsh, Roddy, Wanjiku, Ivy, Ware, James S., Warner, Timothy Q., Wassmer, Evangeline, Watkins, Hugh, Watson, Henry G., Watt, Christopher, Waugh, Dean, Webb, Nick, Webster, Andrew R., Wei, Wei, Welch, Angela, Welch, Steven B., Werring, David, Wessels, Julie, Westbury, Sarah K., Westwood, John Paul W., Wharton, John, Whitehorn, Deborah, Whitworth, James, Wilkins, Martin R., Willcocks, Lisa, Williams, David J., Williamson, Catherine, Wong, Edwin K.S., Wood, Nicholas, Wood, Yvette, Woods, Christopher Geoffrey, Woodward, Emma R., Workman, Sarita, Wort, Stephen J., Yates, Katherine, Yeatman, Nigel, Yong, Patrick F.K., Young, Timothy, Yu, Ping, Yu-Wai-Man, Patrick, Zlamalova, Eliska, Pulmonary medicine, ACS - Pulmonary hypertension & thrombosis, and ACS - Atherosclerosis & ischemic syndromes
- Abstract
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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- 2020
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41. Using Machine Learning to Improve Neutron Tagging Efficiency in Water Cherenkov Detectors
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Stubbs, Matthew and Stubbs, Matthew
- Abstract
When an anti-neutrino collides with a proton in the atomic nucleus, it yields an anti-lepton and a free neutron. In a water Cherenkov neutrino detector like Super-K or the next generation Hyper-K, the free neutron is captured by a hydrogen or gadolinium nucleus about one hundred microseconds after the collision. The low-energy signal from the neutron capture (ranging from 2-8 MeV of gamma rays) is recorded by only tens of photomultiplier tubes (PMTs), making neutron captures difficult to distinguish from radioactive decay, muon spallation and other background sources. Improved methodologies for neutron tagging can advance understanding and enable new research over a survey of topics in particle physics. In this research, machine learning techniques are employed to optimize the neutron capture detection capability in the new intermediate water Cherenkov detector (IWCD) for Hyper-K. In particular, boosting decision tree (XGBoost) and graph neural network (GCN, DGCNN) models are developed and benchmarked against a statistical likelihood-based approach, achieving up to a 10% increase in classification accuracy. Characteristic features are also engineered from the datasets and analyzed using SHAP (SHapley Additive exPlanations) to provide insight into the pivotal factors influencing event type outcomes. Three main datasets were used for evaluative purposes in this research, each consisting of roughly 1.6 million events in total, divided nearly evenly between neutron capture and a distinct background electron source.
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- 2021
42. Transformation from committed progenitor to leukaemia stem cell initiated by MLL–AF9
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Krivtsov, Andrei V., Twomey, David, Feng, Zhaohui, Stubbs, Matthew C., Wang, Yingzi, Faber, Joerg, Levine, Jason E., Wang, Jing, Hahn, William C., Gilliland, D. Gary, Golub, Todd R., and Armstrong, Scott A.
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- 2006
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43. The amino-terminus of the E2F-1 transcription factor inhibits DNA replication of autonomously replicating plasmids in mammalian cells
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Stubbs, Matthew C and Hall, David J
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- 2002
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44. Identification of a novel genetic locus associated with immune-mediated thrombotic thrombocytopenic purpura
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Stubbs, Matthew J., primary, Coppo, Paul, additional, Cheshire, Chris, additional, Veyradier, Agnès, additional, Dufek, Stephanie, additional, Levine, Adam P., additional, Thomas, Mari, additional, Patel, Vaksha, additional, Connolly, John O., additional, Hubank, Michael, additional, Benhamou, Ygal, additional, Galicier, Lionel, additional, Poullin, Pascale, additional, Kleta, Robert, additional, Gale, Daniel P., additional, Stanescu, Horia, additional, and Scully, Marie A., additional
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- 2021
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45. BET Inhibition Enhances the Antileukemic Activity of Low-dose Venetoclax in Acute Myeloid Leukemia
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Ramsey, Haley E., primary, Greenwood, Dalton, additional, Zhang, Susu, additional, Childress, Merrida, additional, Arrate, Maria P., additional, Gorska, Agnieszka E., additional, Fuller, Londa, additional, Zhao, Yue, additional, Stengel, Kristy, additional, Fischer, Melissa A., additional, Stubbs, Matthew C., additional, Liu, Phillip C.C., additional, Boyd, Kelli, additional, Rathmell, Jeffrey C., additional, Hiebert, Scott W., additional, and Savona, Michael R., additional
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- 2021
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46. Editorial note
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Stubbs, Matthew and Webster, Adam
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- 2015
47. Managing alcohol dependence and alcohol-related liver disease: a problem for the hepatologist, psychiatrist or economist?
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Stubbs, Matthew A and Morgan, Marsha Y
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- 2011
48. Characterization of INCB00928, a Potent and Selective ALK2 Inhibitor for the Treatment of Anemia
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Chen, Yaoyu, primary, Stubbs, Matthew C., additional, Pusey, Michelle, additional, Wen, Xiaoming, additional, Collins, Robert J., additional, Kapilashrami, Kanishk, additional, Rupar, Mark, additional, Thekkat, Pramod, additional, Lin, Luping, additional, Bowman, Kevin, additional, Yang, Yan-ou, additional, Diamond, Sharon, additional, Yeleswaram, Swamy, additional, Kim, Sunkyu, additional, Koblish, Holly K., additional, Chen, Yingnan, additional, and Wee, Susan, additional
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- 2020
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49. Nascent transcript and single-cell RNA-seq analysis defines the mechanism of action of the LSD1 inhibitor INCB059872 in myeloid leukemia
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Johnston, Gretchen, primary, Ramsey, Haley E., additional, Liu, Qi, additional, Wang, Jing, additional, Stengel, Kristy R., additional, Sampathi, Shilpa, additional, Acharya, Pankaj, additional, Arrate, Maria, additional, Stubbs, Matthew C., additional, Burn, Timothy, additional, Savona, Michael R., additional, and Hiebert, Scott W., additional
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- 2020
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50. Whole-genome sequencing of a sporadic primary immunodeficiency cohort
- Author
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Thaventhiran, James E.D., Lango Allen, Hana, Burren, Oliver S., Rae, William, Greene, Daniel, Staples, Emily, Zhang, Zinan, Farmery, James H.R., Simeoni, Ilenia, Rivers, Elizabeth, Maimaris, Jesmeen, Penkett, Christopher J., Stephens, Jonathan, Deevi, Sri V.V., Sanchis-Juan, Alba, Gleadall, Nicholas S., Thomas, Moira J., Sargur, Ravishankar B., Gordins, Pavels, Baxendale, Helen E., Brown, Matthew, Tuijnenburg, Paul, Worth, Austen, Hanson, Steven, Linger, Rachel J., Buckland, Matthew S., Rayner-Matthews, Paula J., Gilmour, Kimberly C., Samarghitean, Crina, Seneviratne, Suranjith L., Sansom, David M., Lynch, Andy G., Megy, Karyn, Ellinghaus, Eva, Ellinghaus, David, Jorgensen, Silje F., Karlsen, Tom H., Stirrups, Kathleen E., Cutler, Antony J., Kumararatne, Dinakantha S., Chandra, Anita, Edgar, J. David M., Herwadkar, Archana, Cooper, Nichola, Grigoriadou, Sofia, Huissoon, Aarnoud P., Goddard, Sarah, Jolles, Stephen, Schuetz, Catharina, Boschann, Felix, Abbs, Stephen, Adhya, Zoe, Adlard, Julian, Afzal, Maryam, Ahmed, Irshad, Ahmed, Munaza, Ahmed, Saeed, Aitman, Timothy J., Alachkar, Hana, Alamelu, Jayanthi, Alikhan, Raza, Allen, Carl E., Allen, Louise, Allsup, David J., Alvi, Arif, Ambegaonkar, Gautam, Anantharachagan, Ariharan, Ancliff, Philip, Anderson, Julie, Antrobus, Richard, Armstrong, Ruth, Arno, Gavin, Arumugakani, Gururaj, Arya, Rita, Ashford, Sofie, Astle, William J., Attwood, Anthony, Austin, Steve, Aydinok, Yesim, Ayub, Waqar, Babbs, Christian, Bacchelli, Chiara, Baglin, Trevor, Bakchoul, Tamam, Bariana, Tadbir K., Barratt, Jonathan, Barwell, Julian, Baski, John, Bates, Rachel W., Batista, Joana, Baynam, Gareth, Bennett, David L., Bethune, Claire, Bhatnagar, Neha, Bibi, Shahnaz, Bierzynska, Agnieszka, Biss, Tina, Bitner-Glindzicz, Maria A.K., Bleda, Marta, Blesneac, Iulia, Boardman, Barbara, Boddana, Preetham, Bogaard, Harm J., Booth, Claire, Boyce, Sara, Bradley, John R., Brady, Angela, Breen, Gerome, Brennan, Paul, Brewer, Carole, Briley, Annette, Brown, Richard, Browning, Michael J., Brownlie, Mary, Bryson, Christine J., Buchan, Rachel J., Buck, Jackie, Bueser, Teofila, Diz, Carmen Bugarin, Burns, Siobhan O., Calleja, Paul, Carmichael, Jenny, Carr-White, Gerald, Carss, Keren J., Casey, Ruth, Chalmers, Elizabeth, Chambers, Jenny, Chambers, John, Chan, Melanie M.Y., Chan, Melissa V., Cheng, Floria, Chinn, Ivan K., Chinnery, Patrick F., Chitre, Manali, Chong, Sam, Christian, Martin T., Church, Colin, Clement, Emma M., Brod, Naomi Clements, Clifford, Hayley, Clowes, Virginia E., Coghlan, Gerry, Colby, Elizabeth, Cole, Trevor R.P., Collins, Janine H., Collins, Peter W., Condliffe, Robin, Cook, H. Terence, Cook, Stuart, Cookson, Victoria, Corris, Paul A., Creaser-Myers, Amanda, Crisp-Hihn, Abigail, Curry, Nicola S., Da Costa, Rosa, Danesino, Cesare, Daniels, Matthew J., Darby, Damaris, Daugherty, Louise C., Davies, E. G., Davies, Sophie, Davis, John, de Bree, Godelieve J., Deacock, Sarah, Deegan, Patrick B., Dempster, John, Dent, Timothy, Deshpande, Charu, Devlin, Lisa A., Dewhurst, Eleanor F., Dixit, Anand K., Dixon, Peter H., Doffinger, Rainer, Dolling, Helen, Dormand, Natalie, Downes, Kate, Drazyk, Anna M., Drewe, Elizabeth, Duarte, Daniel, Dutt, Tina, Edwards, Karen E., Egner, William, Ekani, Melanie N., El-Shanawany, Tariq, Elkhalifa, Shuayb, Elston, Tony, Emmerson, Ingrid, Erber, Wendy N., Erwood, Marie, Estiu, Maria C., Evans, Dafydd Gareth, Evans, Gillian, Everington, Tamara, Eyries, Mélanie, Favier, Remi, Firth, Helen V., Fitzpatrick, Maggie M., Fletcher, Debra, Flinter, Frances A., Fox, James C., Frary, Amy J., French, Courtney E., Freson, Kathleen, Frontini, Mattia, Furie, Bruce, Gale, Daniel P., Gall, Henning J., Gardham, Alice, Gaspar, H. Bobby, Gattens, Michael, Ghali, Neeti, Ghataorhe, Pavandeep K., Ghio, Stefano, Ghofrani, Hossein Ardeschir, Ghurye, Rohit, Gibbs, J. Simon R., Gilbert, Rodney D., Girerd, Barbara, Girling, Joanna C., Gissen, Paul, Gorman, Kathleen M., Gosal, David, Graf, Stefan, Grassi, Luigi, Greenhalgh, Alan J., Greenhalgh, Lynn, Greinacher, Andreas, Gresele, Paolo, Griffiths, Philip G., Griffiths, Sian, Grozeva, Detelina, Hackett, Scott J., Hadden, Robert D.M., Hadinnapola, Charaka, Hague, Rosie, Hague, William M., Haimel, Matthias, Hall, Matthew, Halmagyi, Csaba, Hammerton, Tracey, Hanson, Helen L., Harkness, Kirsty, Harper, Andrew R., Harper, Lorraine, Harris, Claire, Harrison, Claire, Hart, Daniel, Hassan, Ahamad, Hayman, Grant, Heemskerk, Johan W.M., Hegde, Shivaram, Henderson, Alex, Henderson, Robert H., Hensiek, Anke, Henskens, Yvonne M.C., Hodgson, Joshua, Hoffman, Jonathan, Holden, Simon, Holder, Muriel, Horvath, Rita, Houlden, Henry, Houweling, Arjan C., Howard, Luke S., Hu, Fengyuan, Hudson, Gavin, Hughes, Sean, Hughes, Stephen, Huis in ‘t Veld, Anna E., Humbert, Marc, Hurles, Matthew E., Hurst, Jane A., Irvine, Val, Izatt, Louise, James, Roger, Jeevaratnam, Praveen, Johnson, Mark, Johnson, Sally A., Jolley, Jennifer D., Jones, Bryony, Jones, Julie, Josifova, Dragana, Jurkute, Neringa, Karim, Yousuf M., Karoshi, Mahantesh A., Kasanicki, Mary A., Kazkaz, Hanadi, Kazmi, Rashid, Keeling, David, Kelleher, Peter, Kelly, Anne M., Kempster, Carly, Kennedy, Fiona, Kiani, Sorena, Kiely, David G., Kingston, Nathalie, Kinsey, Sally, Klein, Nigel, Klima, Robert, Knox, Ellen, Kostadima, Myrto A., Kovacs, Gabor, Koziell, Ania B., Kreuzhuber, Roman, Krishnakumar, Deepa, Kuijpers, Taco W., Kumar, Ajith, Kurian, Manju A., Laffan, James, Laffan, Michael A., Lalloo, Fiona, Lambert, Michele P., Lawman, Sarah H.A., Lawrie, Allan, Layton, D. Mark, Lear, Sara E., Lees, Melissa M., Lentaigne, Claire, Levine, Adam P., Lewington, Andrew J.P., Li, Wei, Liesner, Ri, Liu, Bin, Longhurst, Hilary, Lorenzo, Lorena E., Louka, Eleni, Hadeler, Silvia Lucato, Lyons, Paul A., Macdougall, Malcolm, Machado, Rajiv D., MacKenzie Ross, Robert V., Mackillop, Lucy H., MacLaren, Robert, Madan, Bella, Magee, Laura, Mahdi-Rogers, Mohamed, Maher, Eamonn R., Makris, Mike, Mangles, Sarah, Manson, Ania, Manzur, Adnan, Mapeta, Rutendo, Marchbank, Kevin J., Mark, Patrick B., Marks, Stephen, Markus, Hugh S., Marschall, Hanns Ulrich, Marshall, Andrew, Martin, Jennifer M., Masati, Larahmie, Mathias, Mary, Matser, Vera, Matthews, Emma L., Maw, Anna, Maxwell, Heather, McAlinden, Paul, McCarthy, Mark I., McDermott, Elizabeth M., McGowan, Simon J., McJannet, Coleen, McKinney, Harriet, Meacham, Stuart, Mead, Adam J., Castello, Ignacio Medina, Meehan, Sharon, Mehta, Sarju, Mercer, Catherine L., Michaelides, Michel, Michell, Anna C., Milford, David, Millar, Carolyn M., Millar, Hazel, Mistry, Anoop, Moenen, Floor, Moledina, Shahin, Montani, David, Moore, Anthony T., Moore, Jason, Morrell, Nicholas W., Morrisson, Valerie, Mozere, Monika, Muir, Keith W., Mumford, Andrew D., Murng, Sai H.K., Nasir, Iman, Nejentsev, Sergey, Newnham, Michael, Ng, Joanne, Ngoh, Adeline, Noorani, Sadia, Noori, Muna, Nurden, Paquita, O’Sullivan, Jennifer M., Obaji, Samya, Okoli, Steven, Oksenhendler, Eric, Olschewski, Andrea, Olschewski, Horst, Ong, Albert C.M., Ong, Kai Ren, Oram, Helen, Ormondroyd, Elizabeth, Othman, Shokri, Ouwehand, Willem H., Pantazis, Antonis, Papadia, Sofia, Papandreou, Apostolos, Park, Soo Mi, Parker, Alasdair P.J., Parry, David, Parsons, Georgina, Pasi, K. John, Paterson, Joan, Payne, Jeanette H., Peacock, Andrew J., Peerlinck, Kathelijne, Pepke-Zaba, Joanna, Perry, David, Petersen, Romina, Piechowski-Jozwiak, Bartlomiej, Pinto, Fernando, Polwarth, Gary J., Ponsford, Mark J., Prasad, Sanjay, Prokopenko, Inga, Psaila, Beth, Pyle, Angela, Qasim, Waseem, Quinn, Ellen, Quinti, Isabella, Raina, Sanjay, Ranganathan, Lavanya, Rankin, Julia, Rankin, Stuart, Rao, Anupama, Raymond, F. Lucy, Rehnstrom, Karola, Reid, Evan, Reilly, Mary M., Renton, Tara, Revel-Vilk, Shoshana, Rhodes, Christopher J., Rice, Andrew S.C., Richards, Emma E., Richards, Mike, Richardson, Sylvia, Richter, Alex, Robert, Leema, Roberts, Irene, Rondina, Matthew T., Rosser, Elisabeth, Rothwell, Peter, Roughley, Catherine, Roy, Noemi B., Rue-Albrecht, Kevin, Sadeghi-Alavijeh, Omid, Saleem, Moin A., Salmon, Richard M., Samani, Nilesh J., Sambrook, Jennifer G., Sandford, Richard, Santra, Saikat, Satchell, Simon C., Savic, Sinisa, Scelsi, Laura, Schotte, Gwen, Schulman, Sol, Schulze, Harald, Scott, Richard, Scully, Marie, Searle, Claire, Seeger, Werner, Sewell, W. 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School of Medicine, University of St Andrews. Statistics, University of St Andrews. Sir James Mackenzie Institute for Early Diagnosis, University of St Andrews. Cellular Medicine Division, Ege Üniversitesi, Experimental Immunology, Graduate School, AII - Inflammatory diseases, Infectious diseases, APH - Aging & Later Life, APH - Global Health, Paediatric Infectious Diseases / Rheumatology / Immunology, ARD - Amsterdam Reproduction and Development, Pulmonary medicine, ACS - Pulmonary hypertension & thrombosis, Human genetics, APH - Quality of Care, ACS - Atherosclerosis & ischemic syndromes, Biochemie, RS: Carim - B03 Cell biochemistry of thrombosis and haemostasis, Faculteit FHML Centraal, MUMC+: DA CDL Algemeen (9), RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, MUMC+: MA Hematologie (9), Interne Geneeskunde, and Promovendi CD
- Subjects
0301 basic medicine ,Male ,Protein Tyrosine Phosphatase, Non-Receptor Type 2/genetics ,Genome-wide association study ,VARIANTS ,Regulatory Sequences, Nucleic Acid ,medicine.disease_cause ,Genome ,Cohort Studies ,0302 clinical medicine ,RARE ,QR180 Immunology ,Primary Immunodeficiency Consortium for the NIHR Bioresource ,Genetics ,Protein Tyrosine Phosphatase, Non-Receptor Type 2 ,Multidisciplinary ,Suppressor of Cytokine Signaling 1 Protein/genetics ,GENETIC-VARIATION ,RNA-Binding Proteins ,Primary Immunodeficiency Diseases/diagnosis ,ASSOCIATION ,Penetrance ,Multidisciplinary Sciences ,DEFICIENCY ,QR180 ,Science & Technology - Other Topics ,Female ,General Science & Technology ,Primary Immunodeficiency Diseases ,Transcription Factors/genetics ,Genomics ,COMMON VARIABLE IMMUNODEFICIENCY ,QH426 Genetics ,Biology ,Article ,Actin-Related Protein 2-3 Complex ,03 medical and health sciences ,Suppressor of Cytokine Signaling 1 Protein ,SDG 3 - Good Health and Well-being ,SUPPRESSOR ,Actin-Related Protein 2-3 Complex/genetics ,medicine ,Humans ,QH426 ,Whole genome sequencing ,Science & Technology ,Whole Genome Sequencing ,Common variable immunodeficiency ,DAS ,Bayes Theorem ,Immune dysregulation ,Regulatory Sequences, Nucleic Acid/genetics ,medicine.disease ,RNA-Binding Proteins/genetics ,STAT1 MUTATIONS ,030104 developmental biology ,Primary immunodeficiency ,IUIS PHENOTYPIC CLASSIFICATION ,GAIN ,030215 immunology ,Genome-Wide Association Study ,Transcription Factors - Abstract
Primary immunodeficiency (PID) is characterized by recurrent and often life-threatening infections, autoimmunity and cancer, and it poses major diagnostic and therapeutic challenges. Although the most severe forms of PID are identified in early childhood, most patients present in adulthood, typically with no apparent family history and a variable clinical phenotype of widespread immune dysregulation: about 25% of patients have autoimmune disease, allergy is prevalent and up to 10% develop lymphoid malignancies1–3. Consequently, in sporadic (or non-familial) PID genetic diagnosis is difficult and the role of genetics is not well defined. Here we address these challenges by performing whole-genome sequencing in a large PID cohort of 1,318 participants. An analysis of the coding regions of the genome in 886 index cases of PID found that disease-causing mutations in known genes that are implicated in monogenic PID occurred in 10.3% of these patients, and a Bayesian approach (BeviMed4) identified multiple new candidate PID-associated genes, including IVNS1ABP. We also examined the noncoding genome, and found deletions in regulatory regions that contribute to disease causation. In addition, we used a genome-wide association study to identify loci that are associated with PID, and found evidence for the colocalization of—and interplay between—novel high-penetrance monogenic variants and common variants (at the PTPN2 and SOCS1 loci). This begins to explain the contribution of common variants to the variable penetrance and phenotypic complexity that are observed in PID. Thus, using a cohort-based whole-genome-sequencing approach in the diagnosis of PID can increase diagnostic yield and further our understanding of the key pathways that influence immune responsiveness in humans. © 2020, The Author(s), under exclusive licence to Springer Nature Limited., Wellcome Trust, WT: 104807/Z/14/Z University College London, UCL: 100140/Z/12/Z, 107212/Z/15/Z, MR/L019027, 203141/Z/16/Z, 091157/Z/10/Z Bundesministerium für Bildung und Forschung, BMBF: 01ZX1306A University of Cambridge 201250/Z/16/Z 01ZX1709 Seventh Framework Programme, FP7 NIHR Bristol Biomedical Research Centre Deutsche Forschungsgemeinschaft, DFG Deutsche Forschungsgemeinschaft, DFG: EXC 2167-390884018 Juvenile Diabetes Research Foundation United Kingdom, JDRF: 9-2011-253, 5-SRA-2015-130-A-N National Institute for Health Research, NIHR: RG65966 Medical Research Council, MRC: RG95376, MR/L006197/1 Great Ormond Street Hospital for Children, GOSH, Acknowledgements The NBR-RD PID Consortium is part of the NIHR BioResource, for which funding was provided by the NIHR (NIHR, grant number RG65966). We acknowledge the participation of all NIHR BioResource volunteers, and thank the NIHR BioResource centre and staff for their contribution. J.E.D.T. is supported by the Medical Research Council (MRC) (RG95376 and MR/L006197/1); A.J.T. is supported by the Wellcome Trust (104807/Z/14/Z) and the NIHR Biomedical Research Centre at Great Ormond Street Hospital for Children NHS Foundation Trust and University College London; K.G.C.S. is supported by the MRC (programme grant MR/L019027) and is a Wellcome Investigator; A.J.C. was supported by the Wellcome Trust (091157/Z/10/Z, 107212/Z/15/Z, 100140/Z/12/Z, 203141/Z/16/Z), JDRF (9-2011-253, 5-SRA-2015-130-A-N), NIHR Oxford Biomedical Research Centre and NIHR Cambridge Biomedical Research Centre; E.E. has received funding from the European Union Seventh Framework Programme (FP7-PEOPLE-2013-COFUND) under grant agreement number 609020-Scientia Fellows; E.R. is supported by the Wellcome Trust (201250/Z/16/Z); D.E. is supported by the German Federal Ministry of Education and Research (BMBF) within the framework of the e:Med research and funding concept (SysInflame grant 01ZX1306A; GB-XMAP grant 01ZX1709) and funded by the Deutsche Forschungsgemeinschaft (DFG; German Research Foundation) under Germany’s Excellence Strategy (EXC 2167-390884018). The NIHR Cambridge Biomedical Research Centre (BRC) is a partnership between Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge, funded by the NIHR. This research was co-funded by the support listed above and the NIHR Cambridge BRC.
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- 2020
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