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4. Ecological monitoring of emotional intensity, variability, and instability in individuals with schizophrenia spectrum disorders: Results of a multicentre study.

Author

Zarbo, Cristina, Zamparini, Manuel, Patrono, Alessandra, Calini, Cosima, Harvey, Philip D., Casiraghi, Letizia, Clerici, Massimo, Malvezzi, Matteo, Rocchetti, Matteo, Starace, Fabrizio, and de Girolamo, Giovanni

Subjects
SCHIZOPHRENIA, ENVIRONMENTAL monitoring, PEOPLE with schizophrenia, EMOTIONAL state, MENTAL health personnel, EMOTIONAL experience, WELL-being
Abstract

Background: Evaluating emotional experiences in the life of people with Schizophrenia Spectrum Disorder (SSD) is fundamental for developing interventions aimed at promoting well‐being in specific times and contexts. However, little is known about emotional variability in this population. In DiAPAson project, we evaluated between‐ and within‐person differences in emotional intensity, variability, and instability between people with SSD and healthy controls, and the association with psychiatric severity and levels of functioning. Methods: 102 individuals diagnosed with SSD (57 residential patients, 46 outpatients) and 112 healthy controls were thoroughly evaluated. Daily emotions were prospectively assessed with Experience Sampling Method eight times a day for a week. Statistical analyses included ANOVA, correlations, and generalized linear models. Results: Participants with SSD, and especially residential patients, had a higher intensity of negative emotions when compared to controls. Moreover, all people with SSD reported a greater between‐person‐variability of both positive and negative emotions and greater intra‐variability of negative emotions than healthy controls. In addition, the emotion variability in people with SSD does not follow a linear or quadratic trend but is more "chaotic" if compared to controls. Conclusions: Adequate assessments of positive and negative emotional experiences and their time course in people with SSD can assist mental health professionals with well‐being assessment, implementing targeted interventions through the identification of patterns, triggers, and potential predictors of emotional states. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Ecological monitoring of physical activity, emotions and daily life activities in schizophrenia: the DiAPAson study

Author

Zarbo, Cristina, primary, Rota, Matteo, additional, Calza, Stefano, additional, Crouter, Scott E, additional, Ekelund, Ulf, additional, Barlati, Stefano, additional, Bussi, Riccardo, additional, Clerici, Massimo, additional, Placenti, Roberto, additional, Paulillo, Giuseppina, additional, Pogliaghi, Silvia, additional, Rocchetti, Matteo, additional, Ruggeri, Mirella, additional, Starace, Fabrizio, additional, Zanolini, Stefano, additional, Zamparini, Manuel, additional, and de Girolamo, Giovanni, additional

Published
2023
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6. Patterns of antipsychotic prescription and accelerometer-based physical activity levels in people with schizophrenia spectrum disorders: a multicenter, prospective study

Author

Oliva, Vincenzo, Fanelli, Giuseppe, Zamparini, Manuel, Zarbo, Cristina, Rocchetti, Matteo, Casiraghi, Letizia, Starace, Fabrizio, Martinelli, Alessandra, Serretti, Alessandro, de Girolamo, Giovanni, Pelizza, Lorenzo, the Diapason Consortium, Oliva, V, Fanelli, G, Zamparini, M, Zarbo, C, Rocchetti, M, Casiraghi, L, Starace, F, Martinelli, A, Serretti, A, de Girolamo, G, Oliva, Vincenzo, Fanelli, Giuseppe, Zamparini, Manuel, Zarbo, Cristina, Rocchetti, Matteo, Casiraghi, Letizia, Starace, Fabrizio, Martinelli, Alessandra, Serretti, Alessandro, de Girolamo, Giovanni, Pelizza, Lorenzo, and the Diapason Consortium

Subjects
wearable accelerometer-based biosensor, psychosi, rehabilitation, All institutes and research themes of the Radboud University Medical Center, Humans, Pharmacology (medical), psychosis, Prospective Studies, polypharmacy, Exercise, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], actigraph, antipsychotics, monopharmacy, physical fitness, polypharmacy, psychiatric residential treatment facilities, psychosis, psychotropic drugs, rehabilitation, wearable accelerometer-based biosensor, psychiatric residential treatment facilities, psychotropic drugs, antipsychotic, Psychiatry and Mental health, antipsychotics, Prescriptions, physical fitne, physical fitness, Schizophrenia, actigraph, monopharmacy, psychiatric residential treatment facilitie, psychotropic drug, Antipsychotic Agents
Abstract

Antipsychotic polypharmacy (APP) in patients with schizophrenia spectrum disorders (SSDs) is usually not recommended, though it is very common in clinical practice. Both APP and SSDs have been linked to worse health outcomes and decreased levels of physical activity, which in turn is an important risk factor for cardiovascular diseases and premature mortality. This real-world, observational study aimed to investigate antipsychotic prescribing patterns and physical activity in residential patients and outpatients with SSDs. A total of 620 patients and 114 healthy controls were recruited in 37 centers across Italy. Each participant underwent a comprehensive sociodemographic and clinical evaluation. Physical activity was monitored for seven consecutive days through accelerometer-based biosensors. High rates of APP were found in all patients, with residential patients receiving more APP than outpatients, probably because of greater psychopathological severity. Physical activity was lower in patients compared to controls. However, patients on APP showed trends of reduced sedentariness and higher levels of light physical activity than those in monopharmacy. Rehabilitation efforts in psychiatric residential treatment facilities were likely to result in improved physical activity performances in residential patients. Our findings may have important public health implications, as they indicate the importance of reducing APP and encouraging physical activity.

Published
2023

8. Demographic, clinical, and service-use characteristics related to the clinician’s recommendation to transition from child to adult mental health services

Author

Gerritsen, S. E., van Bodegom, L. S., Dieleman, G. C., Overbeek, M. M., Verhulst, F. C., Wolke, Dieter, Rizopoulos, D., Appleton, R., van Amelsvoort, T. A. M. J., Bodier Rethore, C., Bonnet-Brilhault, F., Charvin, I., Da Fonseca, D., Davidović, N., Dodig-Ćurković, K., Ferrari, A., Fiori, F., Franić, T., Gatherer, C., de Girolamo, G., Heaney, N., Hendrickx, G., Jardri, R., Kolozsvari, A., Lida-Pulik, H., Lievesley, K., Madan, J., Mastroianni, M., Maurice, V., McNicholas, F., Nacinovich, R., Parenti, A., Paul, M., Purper-Ouakil, D., Rivolta, L., de Roeck, V., Russet, F., Saam, M. C., Sagar-Ouriaghli, I., Santosh, P. J., Sartor, A., Schulze, U. M. E., Scocco, P., Signorini, G., Singh, S. P., Singh, J., Speranza, M., Stagi, P., Stagni, P., Street, C., Tah, P., Tanase, E., Tremmery, S., Tuffrey, A., Tuomainen, H., Walker, L., Wilson, A., Maras, A., Adams, Laura, Allibrio, Giovanni, Armando, Marco, Aslan, Sonja, Baccanelli, Nadia, Balaudo, Monica, Bergamo, Fabia, Bertani, Angelo, Berriman, Jo, Boon, Albert, Braamse, Karen, Breuninger, Ulrike, Buttiglione, Maura, Buttle, Sarah, Schandrin, Aurélie, Cammarano, Marco, Canaway, Alastair, Cantini, Fortunata, Cappellari, Cristiano, Carenini, Marta, Carrà, Giuseppe, Ferrari, Cecilia, Chianura, Krizia, Coleman, Philippa, Colonna, Annalisa, Conese, Patrizia, Costanzo, Raffaella, Daffern, Claire, Danckaerts, Marina, de Giacomo, Andrea, Ermans, Jean-Pierre, Farmer, Alan, Fegert, Jörg M., Ferrari, Sabrina, Galea, Giuliana, Gatta, Michela, Gheza, Elisa, Goglia, Giacomo, Grandetto, MariaRosa, Griffin, James, Levi, Flavia Micol, Humbertclaude, Véronique, Ingravallo, Nicola, Invernizzi, Roberta, Kelly, Caoimhe, Killilea, Meghan, Kirwan, James, Klockaerts, Catherine, Kovač, Vlatka, Liew, Ashley, Lippens, Christel, Macchi, Francesca, Manenti, Lidia, Margari, Francesco, Margari, Lucia, Martinelli, Paola, McFadden, Leighton, Menghini, Deny, Miller, Sarah, Monzani, Emiliano, Morini, Giorgia, Mutafov, Todor, O’Hara, Lesley, Negrinotti, Cristina, Nelis, Emmanuel, Neri, Francesca, Nikolova, Paulina, Nossa, Marzia, Cataldo, Maria Giulia, Noterdaeme, Michele, Operto, Francesca, Panaro, Vittoria, Pastore, Adriana, Pemmaraju, Vinuthna, Pepermans, Ann, Petruzzelli, Maria Giuseppina, Presicci, Anna, Prigent, Catherine, Rinaldi, Francesco, Riva, Erika, Roekens, Anne, Rogers, Ben, Ronzini, Pablo, Sakar, Vehbi, Salvetti, Selena, Martinelli, Ottaviano, Sandhu, Tanveer, Schepker, Renate, Siviero, Marco, Slowik, Michael, Smyth, Courtney, Conti, Patrizia, Spadone, Maria Antonietta, Starace, Fabrizio, Stoppa, Patrizia, Tansini, Lucia, Toselli, Cecilia, Trabucchi, Guido, Tubito, Maria, van Dam, Arno, van Gutschoven, Hanne, van West, Dirk, Vanni, Fabio, Vannicola, Chiara, Varuzza, Cristiana, Varvara, Pamela, Ventura, Patrizia, Vicari, Stefano, Vicini, Stefania, von Bentzel, Carolin, Wells, Philip, Williams, Beata, Zabarella, Marina, Zamboni, Anna, Zanetti, Edda, HASH(0x5651c9679ff8), RS: MHeNs - R2 - Mental Health, Psychiatrie & Neuropsychologie, MUMC+: MA Med Staf Spec Psychiatrie (9), Child and Adolescent Psychiatry / Psychology, Epidemiology, Clinical Child and Family Studies, LEARN! - Child rearing, APH - Mental Health, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Lille Neurosciences & Cognition - U 1172 (LilNCog), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre Hospitalier de Versailles André Mignot (CHV), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), CHU Lille, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, The MILESTONE project was funded by EU FP7 programme under grant number 602442. SPS is part-funded by the National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care West Midlands (NIHR CLAHRC WM), now recommissioned as NIHR Applied Research Collaboration West Midlands. The views expressed in this publication are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. PS is the co-inventor of the HealthTrackerTM and is the Chief Executive Officer and shareholder in HealthTracker Ltd. FF is a Chief Technical Officer and AK is the Chief Finance Officer employed by HealthTracker Ltd, respectively. FCV publishes the Dutch translations of ASEBA, from which he receives remuneration. AM was a speaker and advisor for Neurim, Shire, Infectopharm, and Lilly (all not related to transition research)., European Project: 602442,EC:FP7:HEALTH,FP7-HEALTH-2013-INNOVATION-1,MILESTONE(2014), The Milestone Consortium, Gerritsen, S, van Bodegom, L, Dieleman, G, Overbeek, M, Verhulst, F, Wolke, D, Rizopoulos, D, Appleton, R, van Amelsvoort, T, Bodier Rethore, C, Bonnet-Brilhault, F, Charvin, I, Da Fonseca, D, Davidovic, N, Dodig-Curkovic, K, Ferrari, A, Fiori, F, Franic, T, Gatherer, C, de Girolamo, G, Heaney, N, Hendrickx, G, Jardri, R, Kolozsvari, A, Lida-Pulik, H, Lievesley, K, Madan, J, Mastroianni, M, Maurice, V, Mcnicholas, F, Nacinovich, R, Parenti, A, Paul, M, Purper-Ouakil, D, Rivolta, L, de Roeck, V, Russet, F, Saam, M, Sagar-Ouriaghli, I, Santosh, P, Sartor, A, Schulze, U, Scocco, P, Signorini, G, Singh, S, Singh, J, Speranza, M, Stagi, P, Stagni, P, Street, C, Tah, P, Tanase, E, Tremmery, S, Tuffrey, A, Tuomainen, H, Walker, L, Wilson, A, Maras, A, Adams, L, Allibrio, G, Armando, M, Aslan, S, Baccanelli, N, Balaudo, M, Bergamo, F, Bertani, A, Berriman, J, Boon, A, Braamse, K, Breuninger, U, Buttiglione, M, Buttle, S, Schandrin, A, Cammarano, M, Canaway, A, Cantini, F, Cappellari, C, Carenini, M, Carra, G, Ferrari, C, Chianura, K, Coleman, P, Colonna, A, Conese, P, Costanzo, R, Daffern, C, Danckaerts, M, de Giacomo, A, Ermans, J, Farmer, A, Fegert, J, Ferrari, S, Galea, G, Gatta, M, Gheza, E, Goglia, G, Grandetto, M, Griffin, J, Levi, F, Humbertclaude, V, Ingravallo, N, Invernizzi, R, Kelly, C, Killilea, M, Kirwan, J, Klockaerts, C, Kovac, V, Liew, A, Lippens, C, Macchi, F, Manenti, L, Margari, F, Margari, L, Martinelli, P, Mcfadden, L, Menghini, D, Miller, S, Monzani, E, Morini, G, Mutafov, T, O'Hara, L, Negrinotti, C, Nelis, E, Neri, F, Nikolova, P, Nossa, M, Cataldo, M, Noterdaeme, M, Operto, F, Panaro, V, Pastore, A, Pemmaraju, V, Pepermans, A, Petruzzelli, M, Presicci, A, Prigent, C, Rinaldi, F, Riva, E, Roekens, A, Rogers, B, Ronzini, P, Sakar, V, Salvetti, S, Martinelli, O, Sandhu, T, Schepker, R, Siviero, M, Slowik, M, Smyth, C, Conti, P, Spadone, M, Starace, F, Stoppa, P, Tansini, L, Toselli, C, Trabucchi, G, Tubito, M, van Dam, A, van Gutschoven, H, van West, D, Vanni, F, Vannicola, C, Varuzza, C, Varvara, P, Ventura, P, Vicari, S, Vicini, S, von Bentzel, C, Wells, P, Williams, B, Zabarella, M, Zamboni, A, and Zanetti, E

Subjects
Adult mental health service, Adult, Mental Health Services, Parents, Health (social science), Child and adolescent mental health service, Social Psychology, RJ, Epidemiology, ADOLESCENT, Child and adolescent mental health services, Adult mental health services, Young adults, Transition, SDG 3 - Good Health and Well-being, PEOPLE, SCHIZOPHRENIA, Humans, Family, Child, Demography, Mental Disorders, CARE, Psychiatry and Mental health, Young adult, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, RA
Abstract

Purpose The service configuration with distinct child and adolescent mental health services (CAMHS) and adult mental health services (AMHS) may be a barrier to continuity of care. Because of a lack of transition policy, CAMHS clinicians have to decide whether and when a young person should transition to AMHS. This study describes which characteristics are associated with the clinicians’ advice to continue treatment at AMHS. Methods Demographic, family, clinical, treatment, and service-use characteristics of the MILESTONE cohort of 763 young people from 39 CAMHS in Europe were assessed using multi-informant and standardized assessment tools. Logistic mixed models were fitted to assess the relationship between these characteristics and clinicians’ transition recommendations. Results Young people with higher clinician-rated severity of psychopathology scores, with self- and parent-reported need for ongoing treatment, with lower everyday functional skills and without self-reported psychotic experiences were more likely to be recommended to continue treatment. Among those who had been recommended to continue treatment, young people who used psychotropic medication, who had been in CAMHS for more than a year, and for whom appropriate AMHS were available were more likely to be recommended to continue treatment at AMHS. Young people whose parents indicated a need for ongoing treatment were more likely to be recommended to stay in CAMHS. Conclusion Although the decision regarding continuity of treatment was mostly determined by a small set of clinical characteristics, the recommendation to continue treatment at AMHS was mostly affected by service-use related characteristics, such as the availability of appropriate services.

Published
2022

9. Needs for care of residents with schizophrenia spectrum disorders and association with daily activities and mood monitored with experience sampling method: the DIAPASON study

Author

Martinelli, Alessandra, D'Addazio, Miriam, Zamparini, Manuel, Thornicroft, Graham, Torino, Gabriele, Zarbo, Cristina, Rocchetti, Matteo, Starace, Fabrizio, Casiraghi, Letizia, Ruggeri, Mirella, and de Girolamo, Giovanni

Subjects
schizophrenia, psychiatric services, epidemiology, community mental health
Published
2023

10. Interplay between negative symptoms, time spent doing nothing, and negative emotions in patients with schizophrenia spectrum disorders: results from a 37-site study.

Author

D'Anna, Giulio, Zarbo, Cristina, Cardamone, Giuseppe, Zamparini, Manuel, Calza, Stefano, Rota, Matteo, Correll, Christoph U., Rocchetti, Matteo, Starace, Fabrizio, de Girolamo, Giovanni, Barlati, Stefano, Baroncelli, Andrea, Besana, Filippo, Boero, Maria Elena, Clerici, Massimo, Di Michele, Vittorio, Durbano, Federico, Foia, Maria Gabriella, Impicci, Stefania, and Jacoponi, Filippo Maria

Published
2023
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11. Cohort profile

Author

Gerritsen, Suzanne E., Maras, Athanasios, van Bodegom, Larissa S., Overbeek, Mathilde M., Verhulst, Frank C., Wolke, Dieter, Appleton, Rebecca, Bertani, Angelo, Cataldo, Maria G., Conti, Patrizia, Da Fonseca, David, Davidović, Nikolina, Dodig-Ćurković, Katarina, Ferrari, Cecilia, Fiori, Federico, Franić, Tomislav, Gatherer, Charlotte, De Girolamo, Giovanni, Heaney, Natalie, Hendrickx, Gaëlle, Kolozsvari, Alfred, Levi, Flavia Micol, Lievesley, Kate, Madan, Jason, Martinelli, Ottaviano, Mastroianni, Mathilde, Maurice, Virginie, McNicholas, Fiona, O'Hara, Lesley, Paul, Moli, Purper-Ouakil, Diane, de Roeck, Veronique, Russet, Frédérick, Saam, Melanie C., Sagar-Ouriaghli, Ilyas, Santosh, Paramala J., Sartor, Anne, Schandrin, Aurélie, Schulze, Ulrike M. E., Signorini, Giulia, Singh, Swaran P., Singh, Jatinder, Street, Cathy, Tah, Priya, Tanase, Elena, Tremmery, Sabine, Tuffrey, Amanda, Tuomainen, Helena, van Amelsvoort, Therese A. M. J., Wilson, Anna, Walker, Leanne, Dieleman, Gwen C., Adams, Laura, Allibrio, Giovanni, Armando, Marco, Aslan, Sonja, Baccanelli, Nadia, Balaudo, Monica, Bergamo, Fabia, Berriman, Jo, Rethore, Chrystèle Bodier, Bonnet-Brilhault, Frédérique, Boon, Albert, Braamse, Karen, Breuninger, Ulrike, Buttiglione, Maura, Buttle, Sarah, Cammarano, Marco, Canaway, Alastair, Cantini, Fortunata, Cappellari, Cristiano, Carenini, Marta, Carrà, Giuseppe, Charvin, Isabelle, Chianura, Krizia, Coleman, Philippa, Colonna, Annalisa, Conese, Patrizia, Costanzo, Raffaella, Daffern, Claire, Danckaerts, Marina, Giacomo, Andrea de, Dineen, Peter, Ermans, Jean-Pierre, Farmer, Alan, Fegert, Jörg M., Ferrari, Alessandro, Ferrari, Sabrina, Galea, Giuliana, Gatta, Michela, Gheza, Elisa, Goglia, Giacomo, Grandetto, MariaRosa, Griffin, James, Healy, Elaine, Holmes, Keith, Humbertclaude, Véronique, Ingravallo, Nicola, Invernizzi, Roberta, Jardri, Renaud, Keeley, Helen, Kelly, Caoimhe, Killilea, Meghan, Kirwan, James, Klockaerts, Catherine, Kovač, Vlatka, Lida-Pulik, Hélène, Liew, Ashley, Lippens, Christel, Lynch, Fionnuala, Macchi, Francesca, Manenti, Lidia, Margari, Francesco, Margari, Lucia, Martinelli, Paola, McDonald, James, McFadden, Leighton, Menghini, Deny, Migone, Maria, Miller, Sarah, Monzani, Emiliano, Morini, Giorgia, Mutafov, Todor, Nacinovich, Renata, Negrinotti, Cristina, Nelis, Emmanuel, Neri, Francesca, Nikolova, Paulina, Nossa, Marzia, Noterdaeme, Michele, Operto, Francesca, Panaro, Vittoria, Parenti, Aesa, Pastore, Adriana, Pemmaraju, Vinuthna, Pepermans, Ann, Petruzzelli, Maria Giuseppina, Presicci, Anna, Prigent, Catherine, Rinaldi, Francesco, Riva, Erika, Rivolta, Laura, Roekens, Anne, Rogers, Ben, Ronzini, Pablo, Sakar, Vehbi, Salvetti, Selena, Sandhu, Tanveer, Schepker, Renate, Scocco, Paolo, Siviero, Marco, Slowik, Michael, Smyth, Courtney, Spadone, Maria Antonietta, Speranza, Mario, Stagi, Paolo, Stagni, Pamela, Starace, Fabrizio, Stoppa, Patrizia, Tansini, Lucia, Toselli, Cecilia, Trabucchi, Guido, Tubito, Maria, Dam, Arno van, Gutschoven, Hanne Van, West, Dirk van, Vanni, Fabio, Vannicola, Chiara, Varuzza, Cristiana, Varvara, Pamela, Ventura, Patrizia, Vicari, Stefano, Vicini, Stefania, Bentzel, Carolin von, Wells, Philip, Williams, Beata, Zabarella, Marina, Zamboni, Anna, Zanetti, Edda, RS: MHeNs - R2 - Mental Health, Psychiatrie & Neuropsychologie, MUMC+: MA Med Staf Spec Psychiatrie (9), Child and Adolescent Psychiatry / Psychology, Clinical Child and Family Studies, LEARN! - Child rearing, and APH - Mental Health

Subjects
Adult, Internationality, SAMPLE, RJ, child & adolescent psychiatry, ADOLESCENT, Jugendpsychiatrie, Cohort Studies, SDG 3 - Good Health and Well-being, ddc:150, QUALITY-OF-LIFE, Psychiatrische Versorgung, Child psychiatry, Humans, Prospective Studies, SCALE, Demography, Retrospective Studies, Psychiatry, Internationalität, OUTCOMES, DDC 150 / Psychology, Adolescent psychiatry, international health services, General Medicine, WHOQOL-BREF, Europe, Mental Health, Mental health services, CROSS, Adolescent Health Services, EXPERIENCE, Kinderpsychiatrie, adult psychiatry, RA, TRANSITION, RC
Abstract

PurposeThe presence of distinct child and adolescent mental health services (CAMHS) and adult mental health services (AMHS) impacts continuity of mental health treatment for young people. However, we do not know the extent of discontinuity of care in Europe nor the effects of discontinuity on the mental health of young people. Current research is limited, as the majority of existing studies are retrospective, based on small samples or used non-standardised information from medical records. The MILESTONE prospective cohort study aims to examine associations between service use, mental health and other outcomes over 24 months, using information from self, parent and clinician reports.ParticipantsSeven hundred sixty-three young people from 39 CAMHS in 8 European countries, their parents and CAMHS clinicians who completed interviews and online questionnaires and were followed up for 2 years after reaching the upper age limit of the CAMHS they receive treatment at.Findings to dateThis cohort profile describes the baseline characteristics of the MILESTONE cohort. The mental health of young people reaching the upper age limit of their CAMHS varied greatly in type and severity: 32.8% of young people reported clinical levels of self-reported problems and 18.6% were rated to be ‘markedly ill’, ‘severely ill’ or ‘among the most extremely ill’ by their clinician. Fifty-seven per cent of young people reported psychotropic medication use in the previous half year.Future plansAnalysis of longitudinal data from the MILESTONE cohort will be used to assess relationships between the demographic and clinical characteristics of young people reaching the upper age limit of their CAMHS and the type of care the young person uses over the next 2 years, such as whether the young person transitions to AMHS. At 2 years follow-up, the mental health outcomes of young people following different care pathways will be compared.Trial registration numberNCT03013595., publishedVersion

Published
2021

12. Willingness to share contacts in case of COVID-19 positivity–predictors of collaboration resistance in a nation-wide Italian survey

Author

Bikbov, Boris, primary, Tettamanti, Mauro, additional, Bikbov, Alexander, additional, D’Avanzo, Barbara, additional, Galbussera, Alessia Antonella, additional, Nobili, Alessandro, additional, Calamandrei, Gemma, additional, Candini, Valentina, additional, Starace, Fabrizio, additional, Zarbo, Cristina, additional, and de Girolamo, Giovanni, additional

Published
2022
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15. The burden of mental disorders, substance use disorders and self-harm among young people in Europe, 1990–2019: Findings from the Global Burden of Disease Study 2019

Author

Castelpietra, Giulio, primary, Knudsen, Ann Kristin Skrindo, additional, Agardh, Emilie E., additional, Armocida, Benedetta, additional, Beghi, Massimiliano, additional, Iburg, Kim Moesgaard, additional, Logroscino, Giancarlo, additional, Ma, Rui, additional, Starace, Fabrizio, additional, Steel, Nicholas, additional, Addolorato, Giovanni, additional, Andrei, Catalina Liliana, additional, Andrei, Tudorel, additional, Ayuso-Mateos, Jose L, additional, Banach, Maciej, additional, Bärnighausen, Till Winfried, additional, Barone-Adesi, Francesco, additional, Bhagavathula, Akshaya Srikanth, additional, Carvalho, Felix, additional, Carvalho, Márcia, additional, Chandan, Joht Singh, additional, Chattu, Vijay Kumar, additional, Couto, Rosa A.S., additional, Cruz-Martins, Natália, additional, Dargan, Paul I., additional, Deuba, Keshab, additional, da Silva, Diana Dias, additional, Fagbamigbe, Adeniyi Francis, additional, Fernandes, Eduarda, additional, Ferrara, Pietro, additional, Fischer, Florian, additional, Gaal, Peter Andras, additional, Gialluisi, Alessandro, additional, Haagsma, Juanita A., additional, Haro, Josep Maria, additional, Hasan, M. Tasdik, additional, Hasan, Syed Shahzad, additional, Hostiuc, Sorin, additional, Iacoviello, Licia, additional, Iavicoli, Ivo, additional, Jamshidi, Elham, additional, Jonas, Jost B., additional, Joo, Tamas, additional, Jozwiak, Jacek Jerzy, additional, Katikireddi, Srinivasa Vittal, additional, Kauppila, Joonas H., additional, Khan, Moien A.B., additional, Kisa, Adnan, additional, Kisa, Sezer, additional, Kivimäki, Mika, additional, Koly, Kamrun Nahar, additional, Koyanagi, Ai, additional, Kumar, Manasi, additional, Lallukka, Tea, additional, Langguth, Berthold, additional, Ledda, Caterina, additional, Lee, Paul H., additional, Lega, Ilaria, additional, Linehan, Christine, additional, Loureiro, Joana A., additional, Madureira-Carvalho, Áurea M, additional, Martinez-Raga, Jose, additional, Mathur, Manu Raj, additional, McGrath, John J., additional, Mechili, Enkeleint A., additional, Mentis, Alexios-Fotios A., additional, Mestrovic, Tomislav, additional, Miazgowski, Bartosz, additional, Mirica, Andreea, additional, Mirijello, Antonio, additional, Moazen, Babak, additional, Mohammed, Shafiu, additional, Mulita, Francesk, additional, Nagel, Gabriele, additional, Negoi, Ionut, additional, Negoi, Ruxandra Irina, additional, Nwatah, Vincent Ebuka, additional, Padron-Monedero, Alicia, additional, Panda-Jonas, Songhomitra, additional, Pardhan, Shahina, additional, Pasovic, Maja, additional, Patel, Jay, additional, Petcu, Ionela-Roxana, additional, Pinheiro, Marina, additional, Pollok, Richard Charles G., additional, Postma, Maarten J., additional, Rawaf, David Laith, additional, Rawaf, Salman, additional, Romero-Rodríguez, Esperanza, additional, Ronfani, Luca, additional, Sagoe, Dominic, additional, Sanmarchi, Francesco, additional, Schaub, Michael P, additional, Sharew, Nigussie Tadesse, additional, Shiri, Rahman, additional, Shokraneh, Farhad, additional, Sigfusdottir, Inga Dora, additional, Silva, João Pedro, additional, Silva, Renata, additional, Socea, Bogdan, additional, Szócska, Miklós, additional, Tabarés-Seisdedos, Rafael, additional, Torrado, Marco, additional, Tovani-Palone, Marcos Roberto, additional, Vasankari, Tommi Juhani, additional, Veroux, Massimiliano, additional, Viner, Russell M., additional, Werdecker, Andrea, additional, Winkler, Andrea Sylvia, additional, Hay, Simon I., additional, Ferrari, Alize J., additional, Naghavi, Mohsen, additional, Allebeck, Peter, additional, and Monasta, Lorenzo, additional

Published
2022
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16. COVID-19 Vaccine Hesitancy in Italy: Predictors of Acceptance, Fence Sitting and Refusal of the COVID-19 Vaccination

Author

Zarbo, Cristina, primary, Candini, Valentina, additional, Ferrari, Clarissa, additional, d'Addazio, Miriam, additional, Calamandrei, Gemma, additional, Starace, Fabrizio, additional, Caserotti, Marta, additional, Gavaruzzi, Teresa, additional, Lotto, Lorella, additional, Tasso, Alessandra, additional, Zamparini, Manuel, additional, and de Girolamo, Giovanni, additional

Published
2022
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21. Stakeholders’ views on vocational rehabilitation programs: a call for collaboration with Occupational Health Physicians

Author

Mattei, Giorgio, Sacchi, Valentina, Alfieri, Salvatore, Bisi, Antonella, Colombini, Niccolò, Ferrari, Silvia, Giubbarelli, Giuseppe, Gobba, Fabriziomaria, Modenese, Alberto, Pingani, Luca, Rigatelli, Marco, Rossetti, Marisa, Venturi, Giulia, Starace, Fabrizio, and Galeazzi, Gian Maria

Subjects
Adult, Mental Disorders, Teaching, occupational health medicine, Nurses, Rehabilitation, Vocational, economic crisis, Focus Groups, psychiatry, vocational rehabilitation programs, Economic Recession, Mental Health, Economic crisis, Great recession, Occupational health medicine, Psychiatry, Vocational rehabilitation programs, Italy, Stakeholder Participation, Surveys and Questionnaires, Occupational Health Physicians, Prevalence, Humans, Original Article, Great Recession, Occupational Health
Abstract

Background: The triple-dip recession taking place in Italy in 2008-2014 impacted negatively on health, mainly by increasing the rate of unemployment. This increased the prevalence of mental health disorders, while reducing the number of available places on vocational rehabilitation programs (VRPs) delivered by the psychiatric services. Objectives: To explore the different points of views of stakeholders (namely, users and professionals) involved in VRPs developed inside an Italian Community Mental Health Center (CMHC). Methods: A sample of users, psychiatrists, educators and nurses of an Italian CMHC involved in VRPs took part in a focus group. Content analysis was performed with MAXQDA 12, by developing a hierarchical code system a posteriori (i.e., derived from the data). The respondent validation phase was carried out by means of a multiple-choice questionnaire, administered to all participants. Results: A total of 86 emerging issues were coded, divided into two macro-areas: Positive and Negative Reinforcements (48 contributions, 56%, and 38 contributions, 44%, respectively), further subdivided into three areas: professional (service) factors, personal (i.e, user-related) factors, and work environment features (including relationships in the workplace). Some contributions raised issues concerning occupational health protection (e.g. need of information about the rights and duties of the users-workers, as well as the risks they are exposed to in the workplace). Conclusions: The analysis suggested to address specific issues concerning work and VRPs by means of psycho-education group interventions currently carried out at CMHCs, and pointed to the need to foster collaboration between mental health professionals and the occupational health physician of the company where the VRP is started and where the user might be employed.

Published
2018

24. Depression is a risk factor for suboptimal adherence to highly active antiretroviral therapy

Author

Starace, Fabrizio, Ammassari, Adriana, Trotta, Maria Paola, De Longis, Patrizio, Izzo, Crescenzo, Scalzini, Alfredo, Monforte, Antonella d'Arminio, Wu, Albert W., and Antinori, Andrea

Subjects
Depression, Mental -- Prevention, Depression, Mental -- Health aspects, Depression, Mental -- Causes of, Risk factors (Health) -- Analysis, Antiviral agents -- Physiological aspects, AIDS (Disease) -- Research, Health
Abstract

Research has been conducted on affective disorders in persons with HIV infection. The relationship between depression and adherence to antiretroviral regiments has been investigated, and the results indicate that early detection of depression and its proper management can be effective intervention strategy in adherence improvement.

Published
2002

34. Ecological monitoring of emotional intensity, variability, and instability in individuals with schizophrenia spectrum disorders: Results of a multicentre study.

Author

Zarbo C, Zamparini M, Patrono A, Calini C, Harvey PD, Casiraghi L, Clerici M, Malvezzi M, Rocchetti M, Starace F, and de Girolamo G

Abstract

Background: Evaluating emotional experiences in the life of people with Schizophrenia Spectrum Disorder (SSD) is fundamental for developing interventions aimed at promoting well-being in specific times and contexts. However, little is known about emotional variability in this population. In DiAPAson project, we evaluated between- and within-person differences in emotional intensity, variability, and instability between people with SSD and healthy controls, and the association with psychiatric severity and levels of functioning., Methods: 102 individuals diagnosed with SSD (57 residential patients, 46 outpatients) and 112 healthy controls were thoroughly evaluated. Daily emotions were prospectively assessed with Experience Sampling Method eight times a day for a week. Statistical analyses included ANOVA, correlations, and generalized linear models., Results: Participants with SSD, and especially residential patients, had a higher intensity of negative emotions when compared to controls. Moreover, all people with SSD reported a greater between-person-variability of both positive and negative emotions and greater intra-variability of negative emotions than healthy controls. In addition, the emotion variability in people with SSD does not follow a linear or quadratic trend but is more "chaotic" if compared to controls., Conclusions: Adequate assessments of positive and negative emotional experiences and their time course in people with SSD can assist mental health professionals with well-being assessment, implementing targeted interventions through the identification of patterns, triggers, and potential predictors of emotional states., (© 2023 The Authors. International Journal of Methods in Psychiatric Research published by John Wiley & Sons Ltd.)

Published
2023
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35. Comparing Adherence to the Experience Sampling Method Among Patients With Schizophrenia Spectrum Disorder and Unaffected Individuals: Observational Study From the Multicentric DiAPAson Project.

Author

Zarbo C, Zamparini M, Nielssen O, Casiraghi L, Rocchetti M, Starace F, and de Girolamo G

Subjects
Humans, Ecological Momentary Assessment, Affect, Smartphone, Outpatients psychology, Schizophrenia
Abstract

Background: The Experience Sampling Method (ESM) is a valid method of remotely recording activities and mood, but the predictors of adherence to ESM in patients with Schizophrenia Spectrum Disorder (SSD) are not known. Studies on adherence are significant as they highlight the strengths and weaknesses of ESM-based study designs and allow the development of recommendations and practical guidelines for implementing future studies or treatment plans., Objective: The aim of this study was to compare the adherence to ESM in patients with SSD and unaffected control individuals, investigate their patterns, and report the predictors of adherence., Methods: In total, 131 patients with SSD (74 in residential facilities and 57 outpatients) and 115 unaffected control individuals were recruited at 10 different centers in Italy as part of the DiAPAson project. Demographic information, symptom severity, disability level, and level of function were recorded for the clinical sample. Participants were evaluated for daily time use and mood through a smartphone-based ESM 8 times a day for 7 consecutive days. Adherence was measured by the response rate to ESM notifications. Results were analyzed using the chi-square test, ANOVA, Kruskal-Wallis test, and Friedman test, and a logistic regression model., Results: The overall adherence rate in this study was 50% for residents, 59% for outpatients, and 78% for unaffected control individuals. Indeed, patients with SSD had a lower rate of adherence to ESM than the unaffected control group (P≤.001), independent of time slot, day of monitoring, or day of the week. No differences in adherence rates between weekdays and weekends were found among the 3 groups. The adherence rate was the lowest in the late evening time slot (8 PM to 12 AM) and days 6-7 of the study for both patients with SSD and unaffected control individuals. The adherence rate among patients with SSD was not predicted by sociodemographic characteristics, cognitive function, or other clinical features. A higher adherence rate (ie, ≥70%) among patients with SSD was predicted by higher collaboration skills (odds ratio [OR] 2.952; P=.046) and self-esteem (OR 3.394; P=.03), and lower positive symptom severity (OR 0.835; P=.04)., Conclusions: Adherence to ESM prompts for both patients with SSD and unaffected control individuals decreased during late evening and after 6 days of monitoring. Higher self-esteem and collaboration skills predicted higher adherence to ESM among patients with SSD, while higher positive symptom scores predicted lower adherence rates. This study provides important information to guide protocols for future studies using ESM. Future clinical or research studies should set ESM monitoring to waking hours, limit the number of days of monitoring, select patients with more collaborative skills and avoid those with marked positive symptoms, provide intensive training sessions, and improve participants' self-confidence with technologies., International Registered Report Identifier (irrid): RR2-10.1186/s12888-020-02588-y., (©Cristina Zarbo, Manuel Zamparini, Olav Nielssen, Letizia Casiraghi, Matteo Rocchetti, Fabrizio Starace, Giovanni de Girolamo, DiAPAson Collaborators. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 18.07.2023.)

Published
2023
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36. Needs for care of residents with schizophrenia spectrum disorders and association with daily activities and mood monitored with experience sampling method: the DIAPASON study.

Author

Martinelli A, D'Addazio M, Zamparini M, Thornicroft G, Torino G, Zarbo C, Rocchetti M, Starace F, Casiraghi L, Ruggeri M, and de Girolamo G

Subjects
Humans, Female, Ecological Momentary Assessment, Residential Facilities, Italy, Schizophrenia therapy
Abstract

Aims: Care needs represent an essential paradigm in planning residential facility (RF) interventions. However, possible disagreements between users and staff are critical issues in service delivery. The Experience Sampling Method (ESM) tracks experiences in the real world and real time. This study aimed to evaluate the care needs of patients with schizophrenia spectrum disorder (SSD) in RFs and its association with daily activities and mood monitored using the ESM., Methods: As part of the DIAPASON project, 313 residents with SSD were recruited from 99 Italian RFs. Sociodemographic and clinical characteristics were recorded. Care needs, the severity of symptomatology and negative symptoms were assessed. Fifty-six residents were also assessed for 7 consecutive days using the mobile ESM. Descriptive, agreement, predictor and moderator analyses were conducted., Results: The staff rated a higher number of total and met needs than service users ( p < 0.001). Only a slight agreement between users and staff on unmet needs was found in self-care ( k = 0.106) and information ( k = 0.100) needs, while a moderate agreement was found in accommodation ( k = 0.484), food ( k = 0.406), childcare ( k = 0.530), physical health ( k = 0.470), telephone ( k = 0.458) and transport ( k = 0.425) needs. Older age (-0.15; p < 0.01), longer SSD diagnosis (-0.16; p < 0.01), higher collaboration (-0.16; p < 0.01) and lower symptomatology (-0.16; p < 0.01) decreased the number of unmet needs, while being a female (0.27; p < 0.05) and a shorter length of stay in an RF (0.54; p < 0.001) increased the number of unmet needs. A higher number of unmet needs was associated with a lower amount of time spent in leisure activities or reporting a positive mood: on the contrary, more unmet needs were associated with a greater amount of time spent in religious or non-productive activities. The associations between unmet needs rated by staff and users and momentary mood as assessed using the ESM were not moderated by the severity of symptomatology., Conclusions: Although care needs are fundamental in planning residential activities aimed at recovery-oriented rehabilitation, RF interventions did not fully meet users' needs, and some disagreements on unmet needs between users and staff were reported. Further efforts are necessary to overcome Italian RF limits in delivering rehabilitative interventions defined by real users' needs to facilitate users' productivity and progress towards personal recovery.

Published
2023
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37. [Sexual exposure to HIV, sexual behaviour and use of pharmacological post-exposure prophylaxis (PEP)].

Author

Franco A, Starace F, Aprea L, Faella FS, Giordano A, Maiorino C, Manzillo E, Marocco A, Martucci F, Pizzella T, Simioli F, and Izzo CM

Subjects
Adult, Anti-Bacterial Agents administration & dosage, Anti-Bacterial Agents therapeutic use, Anti-HIV Agents administration & dosage, Condoms statistics & numerical data, Counseling, Drug Evaluation, Female, Follow-Up Studies, HIV Infections epidemiology, HIV Infections transmission, Humans, Italy epidemiology, Male, Middle Aged, Patient Education as Topic, Program Evaluation, Rape, Registries, Retrospective Studies, Risk-Taking, Young Adult, Anti-HIV Agents therapeutic use, HIV Infections prevention & control, Sexual Behavior
Abstract

In this study we examined the characteristics of 60 subjects (49 M and 11 F, average age 32.3) out of 195 post-exposure pharmacological prophylaxis (PEP) to HIV, taken in our hospital from 2001 to 2008. The above-mentioned subjects are sexually exposed (or presumably exposed) to HIV. We considered both their sexual intercourse behaviour and protective measures, and sought to infer some trends in sexual behaviour in Italy. All the subjects were monitored until 180 days after exposure, as established by the national guidelines. Only one of the 60 people presented a seroconversion (he dropped out after a 15-day follow-up and after an inadequate 19-day prophylaxis). Another subject, a homosexual male, never previously tested, resulted positive at time 0 both for HIV-Ab and syphilis tests (due to previous risk-sexual exposure), which caused the suspension of the prophylaxis. No HBV, HCV or syphilis seroconversion occurred. Two other homosexual males showed a previously latent positivity to syphilis tests at time 0.

Published
2009

38. [The psychosocial approach to the planning and implementation of vaccine trials for HIV infection].

Author

Starace F, Embrione F, Fusco ML, and Cafaro L

Subjects
Communication, Decision Making, Humans, Motivation, Patient Dropouts, Patient Satisfaction, Physician-Patient Relations, Psychology, Research Subjects economics, Trust, AIDS Vaccines, Clinical Trials as Topic psychology, Patient Acceptance of Health Care psychology, Patient Selection, Research Subjects psychology, Vaccination psychology
Abstract

The production of an effective vaccine for HIV infection is one of the major challenges for the third millennium public health. Here we review published studies addressing the issue of incentives and barriers influencing the choice to participate in a vaccine trial. Currently available literature clearly indicates the need to include psychosocial dimensions in the preparation and implementation of vaccine trials. The underestimation of participants' satisfaction about information communication may lead to non-adherence and to drop-out from the trials. Proper attention to communication skills of professionals involved in participants' enrollment and follow-up is essential to ensure trial success.

Published
2003

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