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Essa pesquisa apresenta as características clínicas e alterações sistêmicas dos pacientes atendidos numa clínica universitária de cirurgia oral. Estudo descritivo em que foram avaliados 304 prontuários de pacientes submetidos a procedimentos cirúrgicos numa clínica de Cirurgia Oral no período de 2013 a 2014. A maioria dos pacientes foi do sexo masculino (n=154; 50,7%), com idade entre 8 e 78 anos, e apresentaram algum tipo de alteração sistêmica (n=144; 47,4%). Os procedimentos mais executados foram as exodontias (54,3%; n=165), e a remoção de restos radiculares (n=165; 55,6%). Ocorreram 35 (11,5%) casos de intercorrências clínicas e 101 (33,2%) possuíam hábitos nocivos com potencial para interfeir no pré, trans e pós-operatório. As alterações sistêmicas foram significativamente associadas à idade (p

Introduction: Mortality and morbidity from bacterial meningitis in African adults is significantly higher than those in better resourced settings. At the same time, the periodontal diseases are highly prevalent and can affect up to 90% of the population. Dental caries in Uganda was recorded in 40% and 62.5% of the children and adults, respectively. We hypothesize that pneumococcal meningitis could interfere in the development of periapical lesion. The aim of this study was to evaluate periapical lesion in Wistar rats subjected to pneumococcal meningitis. Materials and Methods: The animals were divided in control, control/periapical lesion, meningitis, and meningitis/periapical lesion groups. The surgical exposure of molars and the infection of the dental pulp were from the oral environment. Pulp necrosis was induced on the left mandibular first molars during adulthood. Dental pulps were exposed by drilling cavities on the central portion of the occlusal surface with a 1011 HL round bur in high speed to a depth nearly equal to the bur diameter. Animals were subjected to behavioral task and evaluation of the size of periodontal ligament. Data from periodontal ligament space and open field task were reported as mean ± SEM and analysed by Two-way ANOVA and paired Student’s t-test, respectively. Results and Conclusion: Meningitis/periapical increased the periodontal ligament space by 61% when compared with control/ periapical. In the open-field task, there were no differences in the number of crossings and rearing movements between training and test session in meningitis and periapical lesion groups demonstrating habituation memory impairment. Bacterial meningitis and periapical lesion may play an important role in development of cognitive impairment.