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Conservation Science Education Online (CSEO) is a new online resource that shares strategies for teaching science in art conservation and related cultural heritage fields. An overview will be given of how undergraduate chemistry curricula in the United States have used examples from cultural heritage. The field of art conservation will then be described with an emphasis on the science curricula taught in art conservation programs around the world. Challenges include relating theoretical learning to real-world applications and teaching scientific terminology and concepts to students who may have limited science backgrounds; as well, there is a lack of textbooks and resources with appropriate case studies. The newly launched CSEO online resource offers freely available, effective teaching methods in the form of modules developed by international educators in the field. The inaugural CSEO Conference 2022 served as an introduction to the online resource for a global audience and was the first dedicated conference to bring together heritage science educators to discuss challenges and teaching strategies with the goal of building such a resource. The conference facilitated discussions among participants about teaching strategies, with the intention that these topics would become modules for the online resource, available to all science educators.

Analysis of purple dyestuff from a tin labeled "1 oz. Cudbear, No. 1 N. F. Powdered", marketed by the American business S. B. Penick & Company, "Manufacturers of fine drugs and chemicals", confirmed that the material was indeed a lichen dyestuff. It contains the same major orcein components identified in several other lichen dyes and dyed samples dating from the mid-19th century to today. These dyestuffs were analyzed using several analytical techniques. Fluorescence and fiber optic reflectance spectroscopic data for all the samples were similar. High performance liquid chromatography with diode array detection coupled to mass spectrometry confirmed that this commercial American cudbear was very similar to the samples from the United Kingdom but rather different from the archil-dyed reference yarns from Europe. The significance of the observations is discussed, and chemical structures are proposed for several of the unknown dye components detected in this study. [ABSTRACT FROM AUTHOR]

Featured Application: This work presents a potential application in art conservation, specifically in the 'picture cleaning' process. It focuses on experimentally determining room temperature azeotropic solvent blends, which are created by combining two or more solvents in precise concentrations, to maintain a consistent solvent composition during evaporation under ambient conditions. Cleaning painted surfaces of their grime, aged varnishes, and discolored overpaint is one of the most common interventive treatments for art conservators. Carefully concocted solvent mixtures navigate the solubility differences between the material removed and the original paint underneath. However, these solutions may be altered by differential evaporation rates of the component solvents (zeotropic behavior), potentially leading to ineffectively weak cleaning or conversely overly strong residual liquid capable of damaging the underlying paint. Azeotropic solvent blends, which maintain a constant composition during evaporation, offer a promising solution. These blends consist of two or more solvents combined at precise concentrations to function as a single solvent. Additionally, pressure-maximum azeotropes feature higher vapor pressure compared to other mixtures, further minimizing contact time and sorption of the solvents into artworks. This study examines azeotropes of isopropanol with n-hexane and 2-butanone in cyclohexane, which have been used previously in art conservation. The evaporation behavior at room temperature of these boiling point azeotropes was assessed using vapor pressure measurements, refractive index determinations, gravimetric analysis, and gas chromatography. Results showed changes in composition during evaporation and found that the actual room temperature azeotropic composition can vary between 1 and 10% v/v in concentration with those commonly reported at their boiling points. Art conservators should be cautious when using azeotropic blends reported at boiling points significantly higher than room temperature. To ensure the safety and efficacy of these mixtures, it is recommended to determine individual azeotropic cleaning blends experimentally before their use. [ABSTRACT FROM AUTHOR]

The phosphatase and tensin homolog detected on chromosome 10 (PTEN) gene product modulates activation of the phosphatidylinositol 3-kinase (PI3K)/AKT pathway. The PI3K pathway has been found to be involved in the regulation of the fragile X mental retardation protein, which is important for long-term depression and in the formation of new memories. We used delayed fear conditioning and trace fear conditioning to determine learning and memory deficits in neuron subset-specific Pten (NS-Pten) conditional knockout (KO) mice. We found that NS-Pten KO mice had deficits in contextual learning and trace conditioning, but did not have deficits in the ability to learn a conditioned stimulus. Furthermore, we found increased levels in the total and phosphorylated forms of the fragile X mental retardation protein (FMRP) in the hippocampus of NS-Pten KO mice.