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6 results on '"Sizhe Cao"'

1. Screening ANLN and ASPM as bladder urothelial carcinoma-related biomarkers based on weighted gene co-expression network analysis

Author

Tenghao Yang, Zepai Chi, Guoyuan Liu, Xuwei Hong, Sizhe Cao, Kequan Cheng, and Yonghai Zhang

Subjects
ANLN, ASPM, bladder urothelial carcinoma, weighted gene co-expression network analysis, WGCNA, Genetics, QH426-470
Abstract

Introduction: Bladder cancer (BLCA) is one of the most common malignancies in the urinary system with a poor prognosis and high treatment costs. Identifying potential prognostic biomarkers is significant for exploring new therapeutic and predictive targets of BLCA.Methods: In this study, we screened differentially expressed genes using the GSE37815 dataset. We then performed a weighted gene co‐expression network analysis (WGCNA) to identify the genes correlated with the histologic grade and T stage of BLCA using the GSE32548 dataset. Subsequently, Kaplan Meier survival analysis and Cox regression were used to further identify prognosis‐related hub genes using the datasets GSE13507 and TCGA‐BLCA. Moreover, we detected the expression of the hub genes in 35 paired samples, including BLCA and paracancerous tissue, from the Shantou Central Hospital by qRT‐polymerase chain reaction.Results: This study showed that Anillin (ANLN) and Abnormal spindle-like microcephaly-associated gene (ASPM) were prognostic biomarkers for BLCA. High expression of ANLN and ASPM was associated with poor overall survival.The qRT‐PCR results revealed that ANLN and ASPM genes were upregulated in BLCA, and there was a correlation between the expression of ANLN and ASPM in cancer tissues and paracancerous tissue. Additionally, the increasing multiples in the ANLN gene was obvious in high-grade BLCA.Discussion: In summary, this preliminary exploration indicated a correlation between ANLN and ASPM expression. These two genes, serving as the risk factors for BLCA progression, might be promising targets to improve the occurrence and progression of BLCA.

Published
2023
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2. Detection and significance of TNF-α and hs-CRP in the pleural effusion of patients with diabetes and pulmonary tuberculosis

Author

Xin Xue, Yi Qiu, Sizhe Cao, Ying Yue, Xiaofang Sun, and Wen Yan

Subjects
Medicine
Abstract

It is postulated that high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor α (TNF-α) are diagnostic utilities for pleural effusion. This study was designed to explore the detection and significance of TNF-α and hs-CRP in the pleural effusion of patients with diabetes and pulmonary tuberculosis. A total of 60 patients with diabetes and pulmonary tuberculosis pleural effusion were selected as the study group, while 60 patients with pulmonary tuberculosis pleural effusion were considered as the control group. The expression of TNF-α and hs-CRP in the two groups was determined from pleural effusion by enzyme-linked immunosorbent assay (ELISA). The expression levels of TNF-α and hs-CRP in pleural effusion of the study group were significantly ( P

Published
2019
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4. Withdrawal: Associations of tumor necrosis factor‐α polymorphisms with the risk of tuberculosis: a meta‐analysis

Author

Shen Jiang, Ying Yue, Sizhe Cao, Tingting Ma, Yi Qiu, Xin Xue, and Chaolun Gou

Subjects
0301 basic medicine, Tuberculosis, business.industry, 030106 microbiology, Immunology, General Medicine, medicine.disease, 03 medical and health sciences, Meta-analysis, medicine, Cancer research, Gene polymorphism, business, Tumor necrosis factor α
Published
2020
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5. Genetic polymorphisms in TNIP1 increase the risk of gastric carcinoma

Author

Hua Yang, Xiyang Zhang, Qi Zhang, Yiming Li, Yuyan Na, Yuting Shi, Tianbo Jin, Xianglong Duan, Zhao Liu, and Sizhe Cao

Subjects
Adult, Male, 0301 basic medicine, China, medicine.medical_specialty, Pathology, Genotype, case-control study, Zhàng, Protective factor, Gastric carcinoma, Polymorphism, Single Nucleotide, Gastroenterology, Linkage Disequilibrium, 03 medical and health sciences, 0302 clinical medicine, Asian People, Gene Frequency, Risk Factors, Stomach Neoplasms, Internal medicine, Genetic variation, Odds Ratio, Humans, Medicine, Genetic Predisposition to Disease, gastric carcinoma, Alleles, Aged, business.industry, TNIP1 gene, Carcinoma, Haplotype, Case-control study, TNF-α-induced protein 3-interacting protein 1 (TNIP1), single nucleotide polymorphisms (SNPs), Middle Aged, DNA-Binding Proteins, 030104 developmental biology, Haplotypes, Oncology, Case-Control Studies, 030220 oncology & carcinogenesis, Female, business, Research Paper
Abstract

The distribution and levels of TNIP1 in malignant and normal gastric mucosa are different, but it is not known whether TNIP1 polymorphisms are related to gastric carcinogenesis. To assess the association between four TNIP1 SNPs (rs3792792, rs4958881, rs7708392, rs10036748) and carcinogenesis, we used Sequenom Mass-ARRAY technology to determine the genotypes of 302 gastric carcinoma patients and 300 healthy controls in a Northwest Chinese Han population. These data were then compared using the Chi-square test/Fisher's exact test, genetic model analysis, and haplotype analysis. Odds ratios (OR) and 95% confidence intervals (CI) were used to evaluate the correlation. We observed that patients with the “G” allele of rs7708392 and the “C” allele of rs10036748 showed an increased risk of gastric carcinoma (OR= 1.335, 95%CI: 1.021-1.745, P= 0.035; OR= 1.358, 95%CI: 1.039-1.774, P= 0.025, respectively). Conversely, the haplotype “CT” of TNIP1 (rs7708392-rs10036748) may act as a genetic protective factor for gastric carcinoma (adjusted OR= 0.731, 95%CI: 0.552-0.970, P= 0.030). Our results are the first to suggest that genetic variation in TNIP1 gene is associated with gastric carcinoma, though, this finding must be confirmed in other populations with larger sample size.

Published
2016
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6. Application of Thoracoscopic Hybrid Surgery in the Treatment of Stage III Tuberculous Empyema

Author

Lin Wei, Huijun Zhang, Changsheng Zhu, Sizhe Cao, Qian Li, and Zhao Liu

Subjects
Pulmonary and Respiratory Medicine, Tuberculous Empyema, Adult, Male, medicine.medical_specialty, Adolescent, Parietal Pleura, medicine.medical_treatment, Operative Time, Blood Loss, Surgical, Resection, Young Adult, Postoperative Complications, Thoracoscopy, medicine, Humans, Stage (cooking), Aged, medicine.diagnostic_test, business.industry, Gastroenterology, General Medicine, Decortication, Length of Stay, Middle Aged, medicine.disease, bacterial infections and mycoses, Empyema, Surgery, respiratory tract diseases, surgical procedures, operative, Empyema, Tuberculous, Drainage, Female, Original Article, Cardiology and Cardiovascular Medicine, business, Tomography, X-Ray Computed, Pleurectomy
Abstract

Background: To investigate the efficacy and value of thoracoscopic hybrid surgery in the treatment of stage III chronic tuberculous empyema (CTE). Methods: 48 patients diagnosed as CTE with pleural thickening and encysted abscess cavity from were treated by hybrid operation (HO). Small incision operation was first used for resection of thickening pleural fibreboard and decortication of parietal pleura. Then, thoracoscopy was guided into chest to decorticate the visceral pleurali. Additional 25 patients with open operation of pleurectomy were set as control. Results: The average operation time of HO group was 70 ± 22 min compared to 130 ± 32 min of control. The amount of bleeding, hospitalization time and chest tube drainage of HO group (200 ± 55 ml, 18 ± 1.2 days, 3.5 ± 1.5 days) were significantly decreased compared to control (400 ± 45 ml, 28 ± 4.5 days, 6.5 ± 2.5 days). Post operation complications occurred in 5 (10.42%) and 3 (12%) cases for HO group and control, respectively. Conclusions: In stage III CTE, the small incision assisted thoracoscopic hybrid surgery help to remove thickening parietal pleura, promote the application of thoracoscopy, which has obvious advantages compared to traditional surgery.

Published
2015

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