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Sclareol has demonstrated a broad variety of biological activities that belong to the antioxidant anti-inflammatory and anticancer activities that are used in traditional medicine. In the current study, we intended to explore the antitumor possible of sclareol along 7, 12-dimethylbenz (a) anthracene (DMBA) evoked golden Syrian hamster’s buccal pouch carcinogenesis. Lipid peroxidation and antioxidants were assessed by the buccal tissue, and plasma of DMBA evoked golden Syrian hamster buccal pouch carcinogenesis of observational animals. We observed 100% of tumor establishment and noted defects in the biochemical restrictions of lipid peroxidation and antioxidants and also histopathological observations of carcinogenesis in the hamster’s buccal pouch in DMBA only. Sclareol (20 mg/b.wt) has significantly inhibited the tumor burden, tumor volume, and increased phase II detoxification enzymes, antioxidant level, lipid peroxidation, and also phase I enzymes and has improved the histopathologically changes during carcinogenesis in the buccal pouch of DMBA induced golden Syrian hamster. The outcomes of the present scrutinized study proposed that aiming biochemically and histopathologically that act upon the inheritance of cancer characteristics is an effectual system for chemoprevention. Therefore, our results resolved that sclareol has probably owing to its antioxidant or scavenging properties of free radical and transition act on phase I and II enzymes in regards to the evacuation of metabolites carcinogenesis, which is evoked by DMBA in hamster’s buccal pouch.

Background The search for naturally occurring agents in routinely consumed foods that may inhibit cancer development is of high priority. [6]-Paradol is a pungent phenolic bioactive component from ginger with well- documented health promoting antioxidant, antimutagenic, antigenotoxic and anti-inflammatory properties. However, anticarcinogenic effects have yet to be fully explored. The objectives of the present study were therefore to assess protective effects against 7,12-dimethylbenz(a)anthracene (DMBA) induced buccal pouch carcinogenesis in male golden Syrian hamsters. Methods Oral squamous cell carcinomas developed in the left buccal pouch of hamsters on painting with 0.5% of DMBA, three times in a week. To assess the apoptotic associated gene expressing potential of [6]-paradol, it was orally administered to DMBA treated hamsters on alternate days from DMBA painting for 14 weeks. Results We observed 100% tumor formation with marked levels of neoplastic changes and altered the expression of apoptotic associated gene (p53, bcl-2, caspase-3 and TNF-α) was observed in the DMBA alone painted hamsters as compared to control hamsters. Oral administration of [6]-paradol at a dose of 30 mg/kg b.wt to DMBA treated animals on alternative days for 14 weeks significantly reduced the neoplastic changes and improved the status of apoptosis associated gene expression. Conclusion These observations confirmed that [6]-paradol acts as a tumor suppressing agent against DMBA induced oral carcinogenesis. We also conclude that [6]-paradol also effectively enhances apoptosis- associated gene expression in DMBA treated animals.