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1. Sb-Based Mid-Infrared Diode Lasers

Author

FRAUNHOFER-GESELLSCHAFT FREIBURG (GERMANY F R) INST FUER ANGEWANDTE FESTKOERPERPHYSIK, Mermelstein, C., Rattunde, M., Schmitz, J., Simanowski, S., Kiefer, R., FRAUNHOFER-GESELLSCHAFT FREIBURG (GERMANY F R) INST FUER ANGEWANDTE FESTKOERPERPHYSIK, Mermelstein, C., Rattunde, M., Schmitz, J., Simanowski, S., and Kiefer, R.

Abstract

In this paper we review recent progress achieved in our development of type-1 GaInAsSb/AlGaAsSb quantum-well (QW) lasers with emission wavelength in the 1.74 - 2.34 micrometers range. Triple-QW (3-QW) and single-QW (SQW) diode lasers having broadened waveguide design emitting around 2.26 micrometers have been studied in particular. Comparing the two designs we have find that the threshold current density at infinite cavity length as well as the transparency current density scale with the number of QWs. Maximum cw operating temperature exceeding 50 deg C and 90 deg C has been obtained for ridge waveguide lasers emitting above and below 2 micrometers, respectively. Ridge waveguide diode lasers emitting at 1.94 micrometers exhibited internal quantum efficiencies in excess of 77%, internal losses of 6/cm, and threshold current density at infinite cavity length as low as 121 A/sq cm reflecting the superior quality of our diode lasers, all values recorded at 280 K. A high characteristic temperature T(sub O) of 179 K for the threshold current along with a value of T1 = 433 K for the characteristic temperature of the external efficiency have been attained for the 250 - 280 K temperature interval. Room temperature cw output powers exceeding 1.7 W have been demonstrated for broad area single element devices with high-reflection/antireflection coated mirror facets, mounted epi-side down. The latter result is a proof for the high power capabilities of these GaSb-based mid-ir diode lasers., Pub in: Materials Research Society Symposium Proceedings, Volume 692. This article is from ADA405047 Progress in Semiconductor Materials for Optoelectronic Applications Symposium held in Boston, Massachusetts on November 26-29, 2001.

Published
2002

2. The plaque protein myozap identified as a novel major component of adhering junctions in endothelia of the blood and the lymph vascular systems.

Author

Pieperhoff S, Rickelt S, Heid H, Claycomb WC, Zimbelmann R, Kuhn C, Winter-Simanowski S, Kuhn C, Frey N, and Franke WW

Subjects
Animals, Antibody Specificity immunology, Cattle, Cell Line, Electrophoresis, Polyacrylamide Gel, Endothelial Cells metabolism, Endothelium, Vascular ultrastructure, Fluorescent Antibody Technique, Humans, Immunoblotting, Immunoprecipitation, Mice, Myocardium cytology, Myocytes, Cardiac metabolism, Pulmonary Alveoli metabolism, Pulmonary Alveoli ultrastructure, Rats, Sus scrofa, Adherens Junctions metabolism, Endothelium, Vascular metabolism, Lymph metabolism, Lymphatic Vessels metabolism, Membrane Proteins blood, Membrane Proteins metabolism
Abstract

Recently the protein myozap, a 54-kD polypeptide which is not a member of any of the known cytoskeletal and junctional protein multigene families, has been identified as a constituent of the plaques of the composite junctions in the intercalated disks connecting the cardiomyocytes of mammalian hearts. Using a set of novel, highly sensitive and specific antibodies we now report that myozap is also a major constituent of the cytoplasmic plaques of the adherens junctions (AJs) connecting the endothelial cells of the mammalian blood and lymph vascular systems, including the desmoplakin-containing complexus adhaerentes of the virgultar cells of lymph node sinus. In light and electron microscopic immunolocalization experiments we show that myozap colocalizes with several proteins of desmosomal plaques as well as with AJ-specific transmembrane molecules, including VE-cadherin. In biochemical analyses, rigorous immunoprecipitation experiments have revealed N-cadherin, desmoplakin, desmoglein-2, plakophilin-2, plakoglobin and plectin as very stably bound complex partners. We conclude that myozap is a general component of cell-cell junctions not only in the myocardium but also in diverse endothelia of the blood and lymph vascular systems of adult mammals, suggesting that this protein not only serves a specific role in the heart but also a broader set of functions in the vessel systems. We also propose to use myozap as an endothelial cell type marker in diagnoses., (© 2011 The Authors Journal of Cellular and Molecular Medicine © 2011 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd.)

Published
2012
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