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1. A phase 3, multicenter, double-blind, randomized, placebo-controlled clinical trial to verify the efficacy and safety of ansofaxine (LY03005) for major depressive disorder

Author

Weifeng Mi, Xiaolan Di, Yiming Wang, Huafang Li, Xiufeng Xu, Lehua Li, Huaning Wang, Guoqiang Wang, Kerang Zhang, Feng Tian, Jiong Luo, Chanjuan Yang, Yunfei Zhou, Shiping Xie, Hua Zhong, Bin Wu, Dong Yang, Zhenhua Chen, Yi Li, Jindong Chen, Shuyun Lv, Qizhong Yi, Zhiwei Jiang, Jingwei Tian, and Hongyan Zhang

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Abstract Major depressive disorder (MDD) is the most prevalent form of depression and is becoming a great challenge for public health and medical practice. Although first-line antidepressants offer therapeutic benefits, about 35% of depressed patients are not adequately treated, creating a substantial unmet medical need. A multicenter, double-blind, randomized, placebo-controlled phase 3 clinical trial was conducted in patients with MDD in China to assess the efficacy and safety of ansofaxine (LY03005), a potential triple reuptake inhibitor of serotonin, norepinephrine, and dopamine. Eligible 588 MDD patients were included and randomly assigned (1:1:1) to 8-week treatment with ansofaxine 80 mg/day(n = 187), ansofaxine 160 mg/day(n = 186), or placebo(n = 185). The primary efficacy endpoint was the Montgomery-Åsberg Depression Rating Scale (MADRS) total score change from baseline to the end of the study. Safety indexes included adverse events, vital signs, physical examination, laboratory tests, 12-lead electrocardiogram (ECG), and evaluation of suicide tendency and sexual function. Significant differences were found in mean changes in MADRS total score at week 8 in the two ansofaxine groups (80 mg, −20.0; 160 mg, −19.9) vs. placebo (−14.6; p

Published
2023
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2. National survey of therapeutic orientation and associated factors of counselors and psychotherapists in China

Author

Jianxin Liu, Yuping Cao, Chunying Zhou, Yalin Zhang, Ying Liu, Jun Zhang, Qijia Shi, Xueyao Ma, Hong Wei, Xiaomin Liu, Li Hu, Jianqun Wan, Shuyun Lv, and Changqing Jiang

Subjects
associated factors, Licensure, China, Cancer Research, medicine.medical_specialty, counselors and psychotherapists, business.industry, medicine.medical_treatment, Alternative medicine, Clinical supervision, Articles, General Medicine, Psychodynamics, Affect (psychology), Test (assessment), therapeutic orientation, Immunology and Microbiology (miscellaneous), Family medicine, medicine, Cognitive therapy, Psychoanalytic theory, business
Abstract

The aim of the present study was to determine the most commonly used and primary psychotherapeutic orientations adopted by Chinese practitioners and to examine the factors associated with the choice of orientation. A nationwide survey using multi-stage convenience sampling without replacement was conducted. A total of 1,232 respondents out of the 1,325 participants selected completed the survey, which corresponds to an overall response rate of 93.0%. The respondents were practitioners who were providing consultations and psychotherapy in China at the time. The main outcome measures were the most commonly used and primary psychotherapeutic orientations. A Chi-square test was used to examine the factors associated with therapeutic orientation. The most commonly used psychotherapies were cognitive therapy (59.2%), behavioral therapy (38.1%) and the psychoanalytic/psychodynamic model (29.4%). The primary orientations were cognitive therapy (41.6%), the psychoanalytic/psychodynamic model (15.7%) and cognitive-behavioral therapy (10.3%). Gender had no effect on the orientation choice. Cognitive therapy was used significantly more by respondents who were ≤30 years old (50.5%), who had been in practice ≤3 years (45.9%), received continuing education ≤64 h (47.2%) and accepted no clinical supervision (53.1%). Those who were ≥31 years old (18.4%), had been in practice ≥7 years (21.0%), received continuing education ≥65 h (23.6%), worked full-time (20.2%) and accepted clinical supervision (20.6%) used the psychoanalytic/psychodynamic model significantly more. The respondents who used cognitive-behavioral therapy had graduated from the medical profession (14.1%) and were not licensed (15.8%). Cognitive therapy and the psychoanalytic/psychodynamic model were the two most popular orientations adopted by Chinese counselors and psychotherapists. Age, years of practice, graduate profession, continuing education, working hours (full/part-time), licensure and supervision are significant factors that affect the choice of orientation.

Published
2013

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