60 results on '"Shoji Takahashi"'
Search Results
2. Long-term survival after pulmonary resections for multiple metastases from gastric cancer: A case report
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Shoji Takahashi, Hideaki Kojima, Mitsuhiro Isaka, Nozomu Machida, Kazuhito Funai, and Yasuhisa Ohde
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medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Cancer ,Pulmonary resection ,medicine.disease ,Article ,Metastasis ,Early Gastric Cancer ,Pulmonary metastasectomy ,03 medical and health sciences ,0302 clinical medicine ,Pulmonary metastasis ,030220 oncology & carcinogenesis ,Long term survival ,Medicine ,030211 gastroenterology & hepatology ,Surgery ,In patient ,Gastrectomy ,Radiology ,Metastasectomy ,business ,Gastric cancer - Abstract
Highlights • We report a case of long-term survival after pulmonary resections for multiple metastases from gastric cancer. • The prognosis of pulmonary resection for metastatic gastric cancer is poor even though solitary metastasis. • Recently, however, cases of long-term survival have been reported. • By contrast, long-term survival after pulmonary resections for multiple pulmonary metastases from gastric cancer is extremely rare. • Our case suggests that pulmonary metastasectomy could be a therapeutic option even in patients involving multiple pulmonary metastases., Introduction The prognosis of pulmonary resection for metastatic gastric cancer is poor even though solitary metastasis. Long-term survival after pulmonary resections for multiple pulmonary metastases from gastric cancer is extremely rare. Case presentation The patient was 67-year old man who underwent a distal gastrectomy for early gastric cancer. Wedge resections of the right upper and lower lobes and right lower lobectomy were performed for metastases from gastric cancer at 29 months and 55 months after the gastrectomy, respectively. As of 96 months after the first pulmonary metastasectomy, this patient continues to be recurrence-free. Discussion Multiple pulmonary metastases after gastrectomy are not considered candidates for surgery. Although systemic chemotherapy is the standard therapy for metastatic gastric cancer, the prognosis is extremely poor. In this case with favorable prognostic factors, such as long disease-free intervals or absence of extrapulmonary metastasis, pulmonary metastasectomy could be a therapeutic option in patients despite the presence of multiple pulmonary metastases. Conclusions Our case suggests that even in cases involving multiple pulmonary metastases, pulmonary metastasectomy might be an effective therapeutic option that can improve survival.
- Published
- 2018
3. Can 18F-FDG PET predict the grade of malignancy in thymic epithelial tumors? An evaluation of only resected tumors
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Hiroaki Kurihara, Takashi Terauchi, Yasuhisa Ohde, Masahiro Endo, Kazuo Nakagawa, and Shoji Takahashi
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Pathology ,medicine.medical_specialty ,Thymoma ,business.industry ,Significant difference ,Cancer ,Standardized uptake value ,030204 cardiovascular system & hematology ,medicine.disease ,Malignancy ,World health ,03 medical and health sciences ,0302 clinical medicine ,Oncology ,030220 oncology & carcinogenesis ,Tumor stage ,Medicine ,business ,Thymic carcinoma - Abstract
Objective Although 18-fluorine fluorodeoxyglucose positron emission tomography (18F-FDG PET) is thought to be useful for predicting the histological grade of thymic epithelial tumors (TETs), it remains controversial. To date, just a few of many previous studies have included only resected cases. Therefore, we investigated 18F-FDG PET findings only in patients with resected TETs. Patients and methods A total of 112 patients with TETs consisting of 92 thymomas and 20 thymic carcinomas (TCs), resected at two institutes (Shizuoka Cancer Center [Shizuoka] and National Cancer Center Hospital [Tokyo]) between October 2002 and December 2015, were evaluated. Spearman rank correlation coefficient was used to assess the association between the maximum standardized uptake value (SUVmax) in the tumor and both the histological subtype and tumor stage. The cutoff value of SUVmax for differentiating thymoma from TC was calculated. Results The SUVmax was strongly related to both the World Health Organization (WHO) histological subtype and tumor stage based on the eighth edition of the tumor-node-metastasis (TNM) classification (Spearman rank correlation coefficient =0.485 and 0.432; p = 0.000 and 0.000, respectively). There was a significant difference between thymoma and TC. The optimal SUVmax cutoff value for differentiating thymoma from TC was 4.58 (sensitivity: 80% and specificity: 78.3%). In contrast, there was no significant difference between low-risk (type A, AB, and B1) and high-risk (type B2 and B3) thymoma, or between type B3 thymoma and the other subtypes. Conclusion Our results suggest that 18F-FDG PET is useful for differentiating thymoma from TC, but not for predicting the histologic grade of thymoma.
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- 2017
4. Relationship between the Inclination of Adjacent Teeth Caused by Vertical Malposition of the Second Primary Molar – in Relation to Development Stage of First Molar
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Takashi Sasabe, Shigeru Watanabe, Koji Watanabe, Shoji Takahashi, Akihiro Nakamura, and Reina Odai
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Molar ,Environmental Engineering ,business.industry ,Dentistry ,Medicine ,Stage (hydrology) ,Second primary cancer ,business ,Mandibular first molar ,Industrial and Manufacturing Engineering - Published
- 2017
5. Clinical Differentiations in Stump Granuloma and Stump Recurrence After Lung Resection for Malignancy Using a Stapler
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Hideaki Kojima, Reiko Shimizu, Kiyomichi Mizuno, Shoji Takahashi, Mitsuhiro Isaka, Yasuhisa Ohde, Shoko Hayashi, Hiroyuki Kayata, and Yoshiyuki Yasuura
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,business.industry ,030204 cardiovascular system & hematology ,medicine.disease ,Malignancy ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,Oncology ,030220 oncology & carcinogenesis ,Granuloma ,medicine ,Lung resection ,business - Published
- 2017
6. High-Grade Neuroendocrine Carcinoma with Bronchial Intraepithelial Tumor Spread
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Kazuhito Funai, Shoji Takahashi, Reiko Watanabe, Naoko Miyata, Hideaki Kojima, Mitsuhiro Isaka, Toru Kameya, Ichiro Ito, Yasuhisa Ohde, Tomohiro Maniwa, Reiko Shimizu, Takashi Nakajima, and Hiroyuki Kayata
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Pulmonary and Respiratory Medicine ,Bronchus ,Neoplasm Grading ,Pathology ,medicine.medical_specialty ,Lung ,business.industry ,respiratory system ,medicine.disease ,Primary tumor ,respiratory tract diseases ,medicine.anatomical_structure ,Oncology ,medicine ,Carcinoma ,Bronchial neoplasm ,Immunohistochemistry ,business ,Lung cancer - Abstract
Introduction During surgical resection of a peripherally located high-grade neuroendocrine carcinoma (HGNEC), we unexpectedly discovered prominent bronchial intraepithelial tumor spread up to the surgical end of the bronchus. Because bronchial intraepithelial tumor spread of peripherally located HGNEC has been rarely reported, we conducted a retrospective analysis at our hospital. Methods We histologically reviewed surgically resected HGNEC cases to assess bronchial intraepithelial spread of tumor cells. HGNECs with bronchial intraepithelial tumor spread were further studied by immunohistochemistry for neuroendocrine markers, and their clinicopathological characteristics were evaluated. Results Of 1778 cases of surgically resected lung cancer in our hospital, 47 cases of HGNEC were evaluated. Bronchial intraepithelial tumor spread was observed in nine cases (19.1%); eight of these cases were large-cell neuroendocrine carcinoma (LCNEC) or small-cell lung carcinoma with an LCNEC component. Moreover, bronchial intraepithelial tumor spread was continuous from the primary tumor to the resected end of the bronchus in four cases, and all these cases had an LCNEC component. Furthermore, HGNEC with bronchial intraepithelial tumor spread was associated with a higher recurrence rate than no bronchial intraepithelial tumor spread. Conclusion The results of this study suggest that bronchial intraepithelial tumor spread is commonly observed in cases of peripherally located HGNEC and may be a unique form of tumor invasion, especially tumors with LCNEC morphology. Therefore, surgeons and pathologists should be cognizant of bronchial intraepithelial tumor spread in peripherally located HGNEC, as well as its potential role as an indicator of HGNEC aggressiveness.
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- 2015
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7. Prognostic factors of pulmonary metastasectomy for osteosarcoma and soft tissue sarcoma
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Naoko Miyata, Hirohisa Katagiri, Shoji Takahashi, Tomohiro Maniwa, Yasuhisa Ohde, Mitsuhiro Isaka, Reiko Shimizu, Hideaki Kojima, and Hiroyuki Kayata
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medicine.medical_specialty ,business.industry ,Soft tissue sarcoma ,Medicine ,Osteosarcoma ,Radiology ,Metastasectomy ,business ,medicine.disease - Published
- 2015
8. Fluoride retention in the mouth during awake and sleep
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Takahiro Miki, Yoshiaki Ono, Kosuke Tanase, Tethufumi Sano, Chenghua Pai, Hidekazu Oba, Shoji Takahashi, Shigeru Watanabe, and Koji Watanabe
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chemistry.chemical_compound ,chemistry ,business.industry ,Anesthesia ,Medicine ,business ,Sleep in non-human animals ,Fluoride - Published
- 2017
9. Anterior mediastinal cystic seminoma
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Hidenori Goto, Kazutoshi Isobe, Megumi Wakayama, Kazutoshi Shibuya, Keigo Takagi, Fumitomo Sato, Shoji Takahashi, Kazuyoshi Tamaki, and Yoshinobu Hata
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Pulmonary and Respiratory Medicine ,Fluorodeoxyglucose ,medicine.medical_specialty ,Chemotherapy ,endocrine system diseases ,medicine.diagnostic_test ,business.industry ,Mediastinal Seminoma ,medicine.medical_treatment ,Mediastinal tumor ,Magnetic resonance imaging ,General Medicine ,Seminoma ,urologic and male genital diseases ,medicine.disease ,Radiation therapy ,Oncology ,Adjuvant therapy ,medicine ,Radiology ,business ,medicine.drug - Abstract
Mediastinal cystic seminoma is uncommon; only 17 cases have been reported, most diagnosed postoperatively, without recurrence on follow-up, even without radiotherapy. Here, we report a mediastinal seminoma showing a unilocular cyst with enhancing thickened wall in computed tomography (CT) and septal structures in magnetic resonance imaging (MRI) in a 24-year-old man. Fluorodeoxyglucose (FDG) uptake was not significant. Histopathologically, seminoma cells were found scattered in the cyst wall. Twenty months after resection, the patient's quality of life is good, without chemotherapy or radiation. Cystic seminoma has a good prognosis and complete resection without adjuvant therapy might be sufficient for young patients of reproductive age.
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- 2013
10. Continuous paravertebral block using a thoracoscopic catheter-insertion technique for postoperative pain after thoracotomy: a retrospective case-control study
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Tomohiro Maniwa, Eiji Ando, Kamon Ando, Shoji Takahashi, Yoshikane Yamauchi, Mitsuhiro Isaka, Yasuhisa Ohde, Keita Mori, and Hideaki Kojima
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Pulmonary and Respiratory Medicine ,Adult ,Male ,medicine.medical_specialty ,medicine.drug_class ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,Catheterization ,Postoperative pain ,03 medical and health sciences ,0302 clinical medicine ,Paravertebral block ,030202 anesthesiology ,medicine ,Humans ,Paravertebral Block ,Ropivacaine ,Thoracotomy ,Anesthetics, Local ,Aged ,Pain Measurement ,Retrospective Studies ,Aged, 80 and over ,Pain, Postoperative ,Catheter insertion ,Urinary retention ,business.industry ,Thoracoscopy ,Anticoagulant ,Nerve Block ,General Medicine ,Middle Aged ,Amides ,Surgery ,Cardiac surgery ,Catheter ,Treatment Outcome ,Cardiothoracic surgery ,Anesthesia ,Case-Control Studies ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Research Article - Abstract
Background Thoracic epidural analgesia (EDA) is the gold standard for pain control after thoracotomy. However, because of its severe side effects, it is contraindicated in patients taking anticoagulant or antiplatelet drugs. In addition, some patients’ anatomy can make epidural catheter insertion challenging. We therefore investigated the safety and efficacy of paravertebral block (PVB) using a thoracoscopic insertion technique, which avoids damage to the parietal pleura, for postoperative pain after thoracotomy. Methods Patients who underwent thoracotomy with thoracic PVB in our hospital between March 2013 and March 2014 were examined retrospectively. Prior to creating the thoracotomy incision, a catheter for PVB was inserted percutaneously into the paravertebral space under thoracoscopic guidance. A matched-pair control group was selected at a 1:2 ratio from patients who underwent thoracotomy with thoracic EDA in our hospital from April 2011 to February 2013. Pain control and side effects were compared between groups and the results statistically analyzed. Results Thoracic PVB was performed in 56 patients during this period, and 112 patients were selected as matched controls. Numeric Rating Scale scores on postoperative day 2 did not differ significantly between the PVB group (3.25 ± 1.80) and the EDA group (3.56 ± 2.05) (p = 0.334). In terms of side effects, urinary retention occurred less frequently in thoracic PVB patients (p = 0.03). Conclusion Under the conditions of the present study, continuous thoracic PVB was at least as effective as epidural analgesia for postoperative pain control after thoracotomy with lung resection. Electronic supplementary material The online version of this article (doi:10.1186/s13019-017-0566-8) contains supplementary material, which is available to authorized users.
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- 2016
11. Compositional Dependence of the Thermal Properties and Structure of CaO-Al2O3-SiO2 Glasses with a molar ratio of CaO/Al2O3 ^|^gt; 1
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Kou Ueda, Shoji Takahashi, Akira Saitoh, and Hiromichi Takebe
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Materials science ,Molar ratio ,Thermal ,Analytical chemistry ,Mineralogy - Published
- 2012
12. Strength Property of Soil Improvement Auxiliary Material Utilizing Stone Sludge
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Masahide Ishizuka, Shuichi Hasegawa, Hirohiko Iwahara, Shoji Takahashi, and Minoru Yamanaka
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Materials science ,Property (philosophy) ,Waste management ,Mechanics of Materials ,Mechanical Engineering ,General Materials Science ,Condensed Matter Physics - Published
- 2012
13. P2.05-007 Outcomes after Stereotactic Body Radiothrapy/Proton Beam Therapy or Wedge Resection for Stage I Non-Small-Cell Lung Cancer
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Shigeyuki Murayama, Shoji Takahashi, Keita Mori, Hiroyuki Kayata, Yoshiyuki Yasuura, Mitsuhiro Isaka, Hideyuki Harada, Toshiaki Takahashi, Reiko Shimizu, Hideaki Kojima, Tetsuo Nishimura, Yasuhisa Ohde, Shoko Hayashi, and Kiyomichi Mizuno
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Stage I Non-Small Cell Lung Cancer ,Oncology ,business.industry ,Medicine ,Radiology ,business ,Beam (structure) ,Wedge resection (lung) - Published
- 2017
14. P3.04-004 The Risk Factor of the Thrombus Formation in Pulmonary Vein Stump after Left Upper Lobectomy for Lung Cancer
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Yoshiyuki Yasuura, Kiyomichi Mizuno, Masahiro Endo, Hideaki Kojima, Yasuhisa Ohde, Shoko Hayashi, Shoji Takahashi, Reiko Shimizu, Hiroyuki Kayata, and Mitsuhiro Isaka
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,business.industry ,medicine.disease ,030218 nuclear medicine & medical imaging ,Pulmonary vein ,03 medical and health sciences ,0302 clinical medicine ,Oncology ,030220 oncology & carcinogenesis ,Internal medicine ,medicine ,Cardiology ,Thrombus ,Risk factor ,business ,Lung cancer - Published
- 2017
15. Suppressive effects of saliva against enamel demineralization caused by acid beverages
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Kun Xuan, Xiaojing Wang, Shigeru Watanabe, Koji Watanabe, Takashi Ogihara, and Shoji Takahashi
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Orange juice ,Saliva ,Enamel paint ,Chemistry ,business.industry ,Dentistry ,Chewing gum ,Sports drink ,stomatognathic diseases ,fluids and secretions ,stomatognathic system ,Distilled water ,visual_art ,visual_art.visual_art_medium ,Enamel demineralization ,Titration ,Food science ,business - Abstract
This study aimed to clarify the ability of the buffer systems of saliva to inhibit enamel demineralization after intake of an acid beverage. In the first experiment, titrable acidity tests were carried out. Ten milliliters of saliva stimulated by chewing gum base was obtained from 10 healthy adult subjects and the pH of each saliva sample was measured. The beverages used for the experiment were a carbonated soft drink (pH 2.2), a sports drink (pH 3.5), and 100% orange juice (pH 3.8). Distilled water adjusted to the pH of each saliva sample was used as a control. In the second experiment, the suppressive ability of saliva against enamel demineralization was quantitatively analyzed using quantitative light- induced fluorescence (QLF). Aliquots of stimulated saliva obtained from a subject were mixed with 15 ml of 100% orange juice in saliva:orange juice ratios of 1/30, 1/15, 1/10 and 1/5, and bovine teeth were soaked for 24 hours in the solutions. The △Q of the QLF analyses of the enamel was then measured. The lowest titrant volume which reduced the pH of the initial saliva (7.7 on average) to pH 5.4 was that of the orange juice. No relationship was found between the buffer capacity and the pH of the acid beverages. From the QLF measurement, the saliva-orange juice group showed a significantly decreased amount of enamel demineralization (p < 0.01 at 20% level) compared with the distilled water-orange juice group. In conclusion, saliva acts as a buffer to suppress enamel demineralization caused by low-pH beverages.
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- 2011
16. Relation between counts of periodontopathic bacteria in the tongue coat of healthy subjects and the concentration of volatile sulfur compounds in their breath
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Shoji Takahashi, Hiroshi Sakagami, Yoshihiro Ohmori, Shigeru Watanabe, Shigeru Amano, and Reina Kuroshita
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biology ,Aggregatibacter actinomycetemcomitans ,Prevotella intermedia ,biology.organism_classification ,Microbiology ,stomatognathic diseases ,medicine.anatomical_structure ,Tongue ,Pediatrics, Perinatology and Child Health ,medicine ,Dentistry (miscellaneous) ,Anaerobic bacteria ,Fusobacterium nucleatum ,Putrefaction ,Porphyromonas gingivalis ,Bacteria - Abstract
The substances that cause physiological halitosis have been found to be mainly volatile sulfur compounds (VSCs) [hydrogen sulfide (H 2 S), methylmercaptan (CH 3 SH) and dimethylsulfide (CH 3 ) 2 S] produced by putrefaction of anaerobic bacteria. In order to clarify the role of these periodontopathic bacteria in halitosis, we investigated the amounts of four species of bacteria, Prevotella intermedia , Fusobacterium nucleatum , Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans in 10 μl of the tongue coats of healthy people using quantitative PCR and examined the correlation with the concentrations of VSCs present in the subject's breath (physiological halitosis). The following results were obtained. 1.H 2 S in the oral breath of the subjects showed a positive correlation with the detected counts of A. actinomycetemcomitans, P. intermedia, P. gingivalis, F. nucleatum and the total bacteria. 2.CH 3 SH in the oral breath of the subjects showed a positive correlation with the detected count of P. gingivalis. 3.(CH 3 ) 2 S in the oral breath of the subjects showed a positive correlation with the detected counts of A. actinomycetemcomitans, P. intermedia and total bacteria. 4.The concentrations of VSCs in the oral breath of the subjects showed a positive correlation with the total count of bacteria. These results suggest that periodontopathic bacteria present in the tongue coat of healthy people might be the cause of physiological halitosis.
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- 2010
17. P3.16-011 Correlation Between Pulmonary Vein Stump Thrombus and Cerebral Infarction After Left Upper Lobectomy of the Lung
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Hiroyuki Kayata, Shoji Takahashi, Hideaki Kojima, Mitsuhiro Isaka, Y. Terada, K. Sato, Kiyomichi Mizuno, Yoshiyuki Yasuura, Yasuhisa Ohde, and Shoko Hayashi
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Lung ,Cerebral infarction ,business.industry ,medicine.disease ,Pulmonary vein ,medicine.anatomical_structure ,Oncology ,Internal medicine ,medicine ,Cardiology ,Radiology ,Thrombus ,business - Published
- 2017
18. P3.05-006 Integrated Genomic Analysis to Assess the Molecular Signature of Japanese Patients with Non-Small Cell Lung Cancer
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M. Kusuhara, Shoji Takahashi, Akira Ono, T. Sugino, Hideaki Kojima, Yasuhisa Ohde, Masakuni Serizawa, T. Nagashima, Keiichi Ohshima, Ken Yamaguchi, K. Urakami, Mitsuhiro Isaka, Sumiko Ohnami, and Toshiaki Takahashi
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Pulmonary and Respiratory Medicine ,Oncology ,medicine.medical_specialty ,business.industry ,Internal medicine ,medicine ,Non small cell ,Lung cancer ,medicine.disease ,business ,Signature (logic) - Published
- 2017
19. P2.15-008 Genomic Analysis to Assess a Molecular Signature in Japanese Patients with Pulmonary High Grade Neuroendocrine Carcinoma
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T. Sugino, Ken Yamaguchi, Sumiko Ohnami, K. Urakami, Hideaki Kojima, Shoji Takahashi, Mitsuhiro Isaka, Keiichi Ohshima, Toshiaki Takahashi, Akira Ono, M. Kusuhara, Masakuni Serizawa, Yasuhisa Ohde, and T. Nagashima
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Pulmonary and Respiratory Medicine ,Pathology ,medicine.medical_specialty ,Oncology ,business.industry ,Medicine ,Neuroendocrine carcinoma ,business - Published
- 2017
20. The Private Finance Initiative Projects in Medical Institutions
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Shoji, Takahashi
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- 2009
21. Asymmetric Rolling Process Design Using Crystal Plasticity Multiscale Analysis
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Nguyen Ngoc Tam, Shoji Takahashi, Hiroyuki Kuramae, Eiji Nakamachi, Hideo Morimoto, Kazuto Tanaka, and Tsutao Katayama
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Materials science ,Mechanics of Materials ,business.industry ,Mechanical Engineering ,General Materials Science ,Process design ,Structural engineering ,business ,Crystal plasticity - Published
- 2009
22. Two cases of lung adenocarcinoma in the right upper lobe who developed acute preoperative respiratory failure: Usefulness of emergency rigid bronchoscope intervention
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Kazuyoshi Tamaki, Nobuhide Kato, Shoji Takahashi, Yoshinobu Hata, Shuichi Sasamoto, and Keigo Takagi
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medicine.medical_specialty ,Lung ,medicine.anatomical_structure ,Respiratory failure ,business.industry ,Rigid bronchoscope ,medicine ,Adenocarcinoma ,Right upper lobe ,Radiology ,business ,medicine.disease - Abstract
主気管支腔内を中枢側進展し,一側無気肺による急性呼吸不全を来たした右上葉肺癌に対し,全身麻酔硬性気管支鏡下腫瘍debulkingを施行し,その後待機的根治切除を行った2例を経験した.いずれも低分化型腺癌で,右主気管支の腫瘍を硬性外筒でcore outし,無気肺を改善させてから,待機的に右上葉管状切除術を施行した.症例1は46歳,男性,病理病期III b期(p-T4N2M0)で,現在術後39ヵ月で無再発生存中であり,症例2は79歳男性,病理病期II b期(p-T3N0M0)で,術後日常生活に復したが術後5ヵ月で腫瘍死となった.硬性気管支鏡下腫瘍debulkingは,QOLの一時的な改善のみならず,肺癌に対するその後の集学的治療をすすめる上で有用であった.
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- 2008
23. High-Grade Neuroendocrine Carcinoma with Bronchial Intraepithelial Tumor Spread: Possibly a New Histologic Feature of Large-Cell Neuroendocrine Carcinoma
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Hideaki, Kojima, Reiko, Watanabe, Mitsuhiro, Isaka, Reiko, Shimizu, Hiroyuki, Kayata, Naoko, Miyata, Tomohiro, Maniwa, Shoji, Takahashi, Ichiro, Ito, Toru, Kameya, Kazuhito, Funai, Yasuhisa, Ohde, and Takashi, Nakajima
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Aged, 80 and over ,Male ,Bronchial Neoplasms ,Carcinoma, Large Cell ,Humans ,Female ,Middle Aged ,Neoplasm Grading ,Aged ,Carcinoma, Neuroendocrine - Abstract
During surgical resection of a peripherally located high-grade neuroendocrine carcinoma (HGNEC), we unexpectedly discovered prominent bronchial intraepithelial tumor spread up to the surgical end of the bronchus. Because bronchial intraepithelial tumor spread of peripherally located HGNEC has been rarely reported, we conducted a retrospective analysis at our hospital.We histologically reviewed surgically resected HGNEC cases to assess bronchial intraepithelial spread of tumor cells. HGNECs with bronchial intraepithelial tumor spread were further studied by immunohistochemistry for neuroendocrine markers, and their clinicopathological characteristics were evaluated.Of 1778 cases of surgically resected lung cancer in our hospital, 47 cases of HGNEC were evaluated. Bronchial intraepithelial tumor spread was observed in nine cases (19.1%); eight of these cases were large-cell neuroendocrine carcinoma (LCNEC) or small-cell lung carcinoma with an LCNEC component. Moreover, bronchial intraepithelial tumor spread was continuous from the primary tumor to the resected end of the bronchus in four cases, and all these cases had an LCNEC component. Furthermore, HGNEC with bronchial intraepithelial tumor spread was associated with a higher recurrence rate than no bronchial intraepithelial tumor spread.The results of this study suggest that bronchial intraepithelial tumor spread is commonly observed in cases of peripherally located HGNEC and may be a unique form of tumor invasion, especially tumors with LCNEC morphology. Therefore, surgeons and pathologists should be cognizant of bronchial intraepithelial tumor spread in peripherally located HGNEC, as well as its potential role as an indicator of HGNEC aggressiveness.
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- 2015
24. Retrocardiac lung hernia after thoracic esophagectomy: report of a rare case
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Yasuhiro Tsubosa, Masahiro Niihara, Keisuke Kawamorita, Yasuhisa Ohde, Shoji Takahashi, and Akinobu Furutani
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Esophageal surgery ,medicine.medical_specialty ,Lung ,business.industry ,medicine.medical_treatment ,Lung hernia ,Mediastinum ,Case Report ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Esophagectomy ,Laparotomy ,medicine ,Hernia ,Thoracotomy ,business ,Bulla (amulet) - Abstract
A retrocardiac lung hernia is an extremely rare complication after esophagectomy. A 56-year-old man was admitted to our hospital with advanced middle thoracic esophageal cancer and a giant bulla at the apical portion of the right lung. Since it appeared that dissection of the upper mediastinum would most likely require resection of the right bulla, a two-stage operation for esophageal cancer was planned. During the first-stage operation, thoracic esophagectomy and resection of the right giant bulla were performed. Fourteen days after the first-stage operation, the patient underwent laparotomy as the second-stage operation to reconstruct a narrow gastric tube via a retrosternal route. After the second-stage operation, the inflammatory reaction was prolonged. Therefore, a thoracoabdominal computed tomography scan was performed, showing retrocardiac pulmonary atelectasis. The patient was diagnosed with a retrocardiac left lung hernia in which the left lower lobe was displaced into the right thoracic cavity. Because the inflammatory reaction was due to effects of the lung hernia, a repair operation was performed via a left seventh intercostal thoracotomy. At thoracotomy, the left basal segment of the lung was atelectatic and reddish and had herniated into the right thoracic cavity through an opening between the aorta and pericardium. The herniated lung tip adhered strongly to the subcarina, and synechiotomy was performed. We believe that simultaneous removal of the right giant bulla with esophagectomy was the important cause of this complication.
- Published
- 2015
25. Enzymatic Assay for<scp>D</scp>-Aspartic Acid Using<scp>D</scp>-Aspartate Oxidase and Oxaloacetate Decarboxylase
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Tohru Yoshimura, Yoshio Kera, Shoji Takahashi, Shiro Kato, Tomoyuki Ikuta, and Hisashi Hemmi
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Male ,D-aspartate oxidase ,D-Aspartate Oxidase ,Carboxy-Lyases ,Swine ,Stereochemistry ,Phaeophyta ,Applied Microbiology and Biotechnology ,Biochemistry ,Analytical Chemistry ,chemistry.chemical_compound ,D-Aspartic Acid ,Testis ,Animals ,Molecular Biology ,Enzyme Assays ,chemistry.chemical_classification ,Aspartic Acid ,Oxidase test ,biology ,α keto acid ,Organic Chemistry ,General Medicine ,biology.organism_classification ,Lactic acid ,Enzyme ,Oxaloacetate decarboxylase ,chemistry ,Bacteria ,Biotechnology - Abstract
An enzymatic assay system for D-Asp was established using D-aspartate oxidase and oxaloacetate decarboxylase. In this system, D-Asp is converted to pyruvate, which is determined fluorometrically with 1,2-diamino-4,5-methylenedioxybenzene. This method makes possible D-Asp measurement at the micromolar level. The D-Asp contents of an edible brown alga, Hijika fusiforme, a lactic acid bacteria beverage, and pig testis were determined by the method.
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- 2012
26. OA18.05 FDG-PET in Thymic Epithelial Tumors: An Evaluation of Only Resected Tumors
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Takashi Terauchi, Yasuhisa Ohde, Kazuo Nakagawa, Shoji Takahashi, and Hiroaki Kurihara
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Pulmonary and Respiratory Medicine ,Pathology ,medicine.medical_specialty ,Oncology ,business.industry ,Medicine ,business - Published
- 2017
27. P1.08-075 Salvage Surgery for Stage IV Non-Small Cell Lung Cancer
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Toshiaki Takahashi, Reiko Shimizu, Yoshiyuki Yasuura, Hideaki Kojima, Mitsuhiro Isaka, Shoji Takahashi, Hiroyuki Kayata, Yasuhisa Ohde, Shoko Hayashi, and Kiyomichi Mizuno
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Oncology ,business.industry ,Locally advanced ,Medicine ,Salvage surgery ,business ,Stage IV non-small cell lung cancer ,Surgery - Published
- 2017
28. P2.02-031 Survival Data of Postoperative Adjuvant Chemotherapy of Cisplatin plus Vinorelbine for Completely Resected NSCLC: A Retrospective Study
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Haruyasu Murakami, Masahiro Endo, Yasuhisa Ohde, Shoji Takahashi, Shota Omori, Toshiaki Takahashi, Kazuhisa Nakashima, Hirotsugu Kenmotsu, Hideaki Kojima, Mitsuhiro Isaka, Kazushige Wakuda, Tateaki Naito, and Akira Ono
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Pulmonary and Respiratory Medicine ,Oncology ,Cisplatin ,medicine.medical_specialty ,Adjuvant chemotherapy ,business.industry ,Multimodality Treatment ,Retrospective cohort study ,Vinorelbine ,Survival data ,Internal medicine ,medicine ,business ,medicine.drug - Published
- 2017
29. Prospective genetic profiling of squamous cell lung cancer and adenosquamous carcinoma in Japanese patients by multitarget assays
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Yasuhisa Ohde, Mitsuhiro Isaka, Masakuni Serizawa, Tetsuhiko Taira, Isamu Hayashi, Shoji Takahashi, Yasuhiro Koh, Takashi Y. Nakajima, Masahiro Endo, Hirotsugu Kenmotsu, Nobuyuki Yamamoto, Akira Ono, Tomohiro Maniwa, Masato Abe, Toshiaki Takahashi, and Keita Mori
- Subjects
Adult ,Male ,Oncology ,Neuroblastoma RAS viral oncogene homolog ,Cancer Research ,medicine.medical_specialty ,Lung Neoplasms ,DNA Copy Number Variations ,Genotyping Techniques ,Adenosquamous carcinoma ,PIK3CA mutation ,medicine.disease_cause ,Carcinoma, Adenosquamous ,Asian People ,Japan ,Risk Factors ,Squamous cell carcinoma ,Internal medicine ,Genotype ,Genetics ,medicine ,ROS1 ,Humans ,Genetic profiling ,Prospective Studies ,Lung cancer ,Aged ,Biological Specimen Banks ,Neoplasm Staging ,Aged, 80 and over ,business.industry ,Gene Expression Profiling ,Cancer ,Driver mutation ,Middle Aged ,medicine.disease ,Adenosquamos carcinoma ,FGFR1 copy number gain ,Mutation ,Carcinoma, Squamous Cell ,Adenocarcinoma ,Female ,KRAS ,Neoplasm Grading ,business ,Research Article - Abstract
Background Despite considerable recent progress in the treatment of lung adenocarcinoma, there has been little progress in the development of efficacious molecular targeted therapies for squamous cell lung cancer. In addition to the recent comprehensive genome-wide characterization of squamous cell lung cancer, it is also important to genotype this form of cancer. We therefore conducted the Shizuoka Lung Cancer Mutation Study to analyze driver mutations in patients with thoracic malignancies. Here we report the results of genotyping in patients with squamous cell lung cancer. Methods Based on the biobanking system, in conjunction with the clinic and pathology lab, we developed a genotyping panel designed to assess 24 mutations in 10 genes (EGFR, KRAS, BRAF, PIK3CA, NRAS, MEK1, AKT1, PTEN, HER2 and DDR2), EGFR, MET, PIK3CA, FGFR1 and FGFR2 copy numbers, and EML4-ALK and ROS1 translocations, using pyrosequencing plus capillary electrophoresis, quantitative polymerase chain reaction (PCR) and reverse-transcription PCR, respectively. Results A total of 129 patients with squamous cell lung cancer and adenosquamous carcinoma were enrolled in this study between July 2011 and November 2012. We detected genetic alterations in 40% of all cases. Gene alterations included: EGFR mutations, 6%; KRAS mutations, 4%; PIK3CA mutations, 13%; NRAS mutations, 1%; KIF5b-RET fusion gene, 1%; EGFR copy number gain, 5%; PIK3CA copy number gain, 15%; and FGFR1 copy number gain, 5%. Twelve patients (9%) harbored simultaneous genetic alterations. Genetic alterations were detected more frequently in surgically-resected, snap-frozen samples than in formalin-fixed, paraffin-embedded samples (50% vs. 29%). In addition, patients aged ≤70 years old and never-smokers showed high frequencies of genetic alterations. Conclusions This study represents one of the largest prospective tumor-genotyping studies to be performed in Asian patients with squamous cell lung cancer. These results suggest that incorporation of genetic profiling into lung cancer clinical practice may facilitate the administration of personalized cancer treatments in patients with squamous cell lung cancer. Electronic supplementary material The online version of this article (doi:10.1186/1471-2407-14-786) contains supplementary material, which is available to authorized users.
- Published
- 2014
30. Prognostic significance of postoperative serum carcinoembryonic antigen levels in patients with completely resected pathological-stage I non-small cell lung cancer
- Author
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Mitsuhiro Isaka, Takashi Nakajima, Yoshiki Kozu, Shoji Takahashi, Tomohiro Maniwa, and Yasuhisa Ohde
- Subjects
Adult ,Male ,Pulmonary and Respiratory Medicine ,Oncology ,medicine.medical_specialty ,Lung Neoplasms ,medicine.medical_treatment ,Gastroenterology ,Carcinoembryonic antigen ,Japan ,Non-small cell lung cancer ,Antigens, Neoplasm ,Carcinoma, Non-Small-Cell Lung ,Unfavorable prognostic factor ,Internal medicine ,medicine ,Carcinoma ,Humans ,Postoperative Period ,Lung cancer ,neoplasms ,Pathological ,Survival analysis ,Aged ,Retrospective Studies ,Aged, 80 and over ,Keratin-19 ,Chemotherapy ,biology ,business.industry ,Retrospective cohort study ,Pathological-stage I ,General Medicine ,Perioperative ,Middle Aged ,Prognosis ,medicine.disease ,Survival Analysis ,Carcinoembryonic Antigen ,Adjuvant chemotherapy ,Chemotherapy, Adjuvant ,Multivariate Analysis ,biology.protein ,Female ,Surgery ,Postoperative carcinoembryonic antigen level ,Cardiology and Cardiovascular Medicine ,business ,Research Article - Abstract
Background Until date, there are no clear recommendations for regular perioperative measurements of serum CEA levels for lung cancer in any guidelines. The purpose in the present study is to evaluate the prognostic significance of perioperative serum carcinoembryonic antigen (CEA) levels in patients with pathological-stage I non-small cell lung cancer (NSCLC). Methods We retrospectively reviewed 263 completely resected pathological-stage I NSCLC patients whose preoperative and postoperative serum CEA levels were measured. Patients were subdivided according to the perioperative change of CEA levels: continuously normal CEA levels (NN group), continuously high CEA levels (HH group), and high preoperative CEA levels that returned to normal levels post-operation (HN group). The clinicopathological factors and overall survival (OS) among these 3 groups were compared. Univariate and multivariate analyses of the correlation between clinicopathological factors and OS were performed. Results High preoperative CEA levels significantly correlated with men aged >70 years with smoking history, high serum CYFRA 21–1 levels, greater tumor diameter, presence of visceral pleural invasion (VPI), and moderate-to-poor differentiation. Five-year OS rates in the NN and HH groups were 95.5% and 59.3%, respectively. Four-year OS rate in the HN group was 85.5%. Multivariate analyses indicated tumor diameter of more than 30 mm, presence of VPI, and the HH group were independent unfavorable prognostic factors. Conclusions A high postoperative CEA level was an independent unfavorable prognostic factor in pathological-stage I NSCLC patients. Patients with high postoperative CEA levels may benefit from adjuvant chemotherapy.
- Published
- 2013
31. Risk factors for both recurrence and survival in patients with pathological stage I non-small-cell lung cancer
- Author
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Yoshiki Kozu, Tomohiro Maniwa, Takashi Y. Nakajima, Mitsuhiro Isaka, Yasuhisa Ohde, and Shoji Takahashi
- Subjects
Pulmonary and Respiratory Medicine ,Oncology ,Adult ,Male ,medicine.medical_specialty ,Lung Neoplasms ,Kaplan-Meier Estimate ,Preoperative care ,Disease-Free Survival ,Carcinoembryonic antigen ,Recurrence ,Risk Factors ,Internal medicine ,Carcinoma, Non-Small-Cell Lung ,Medicine ,Humans ,Risk factor ,Lung cancer ,Pathological ,Aged ,Retrospective Studies ,Aged, 80 and over ,Analysis of Variance ,biology ,business.industry ,Cancer ,Histology ,General Medicine ,Middle Aged ,medicine.disease ,Carcinoembryonic Antigen ,biology.protein ,Population study ,Surgery ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
OBJECTIVES: Even after curative resection, a significant fraction of patients with stage I non-small-cell lung cancer (NSCLC) die primarily because of systemic relapse. The purpose of the present study was to investigate the risk factors for both recurrence and poor survival in patients with pathological (p-) stage I NSCLC. METHODS: We retrospectively reviewed 467 consecutive patients from a single institution with completely resected p-stage I NSCLC. Patients with multiple lung tumours or malignancies from other organs and those who had undergone preoperative therapies were excluded. The correlation between clinicopathological factors and surgical outcomes, including disease-free survival (DFS) and overall survival (OS), was analysed. The clinicopathological factors examined were age, gender, smoking history, serum carcinoembryonic antigen (CEA) levels, serum cytokeratin 19 fragment levels, surgical procedure, tumour histology, p-stage, angiolymphatic invasion and differentiation grade. RESULTS: The 5-year DFS and OS rates of the total study population were 91.4 and 92.8%, respectively. Multivariate analysis results indicated that high serum CEA levels (>5.0 ng/ml) and p-stage IB were independent factors for recurrence, whereas older age (>70 years), high serum CEA levels and p-stage IB were independent factors for poor survival. The risks of recurrence and death in patients with both high serum CEA levels and p-stage IB was 10.3 and 5.2 times higher than those observed in patients with both normal serum CEA levels and p-stage IA, respectively. CONCLUSIONS: High serum CEA levels and p-stage IB were independent factors for both recurrence and poor survival in p-stage I NSCLC patients.
- Published
- 2013
32. Recovery of lung perfusion after sleeve resection for tuberculous bronchial stenosis
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Kazutoshi Shibuya, Kazuyoshi Tamaki, Shuichi Sasamoto, Fumitomo Sato, Shoji Takahashi, Keigo Takagi, Aki Mitsuda, Yoshinobu Hata, and Keita Sato
- Subjects
Pulmonary and Respiratory Medicine ,Adult ,medicine.medical_specialty ,Perfusion scanning ,Bronchi ,Constriction, Pathologic ,Bronchial stenosis ,Postoperative Complications ,Sleeve resection ,Ischemia ,Bronchoscopy ,medicine ,Humans ,Exertion ,Lung ,Tuberculosis, Pulmonary ,business.industry ,Bronchomalacia ,Lung perfusion ,Bronchial Diseases ,respiratory system ,medicine.disease ,respiratory tract diseases ,Surgery ,Respiratory Function Tests ,Airway Obstruction ,Stenosis ,Female ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,Tomography, X-Ray Computed ,Perfusion - Abstract
Parenchyma-sparing main bronchial sleeve resection is a safe and effective procedure to restore impaired lung function. We present a case illustrating recovery of lung perfusion in a 24-year-old woman with dyspnea on exertion because of bronchial tuberculosis. Bronchoscopic examination revealed pin-hole stenosis of the left main bronchial orifice. 99mTc-macroaggregated albumin perfusion scanning revealed essentially absent left lung perfusion. Because of bronchomalacia in the distal portion, six rings of the left main bronchus were resected by carinoplasty. Symptoms abated and perfusion recovered to a large extent 2 months later. She became pregnant and delivered successfully 12 months postoperatively.
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- 2011
33. Introduction of Boundary-layer Wind Tunnel
- Author
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Shoji Takahashi, Yoshimi Suyama, Shuichi Takakura, Taimei Aoki, and Naoki Yoshimura
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Boundary layer wind tunnel ,Mechanics ,Geology - Published
- 1993
34. P-169 * SIGNIFICANCE OF THE PRESENCE OF MICROSCOPIC VASCULAR INVASION AFTER COMPLETE RESECTION OF NON-SMALL-CELL LUNG CANCER
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Yasuhisa Ohde, Naoko Miyata, Hideaki Kojima, Masayoshi Nagata, Mitsuhiro Isaka, Shoji Takahashi, Yoshikane Yamauchi, and Tomohiro Maniwa
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Pulmonary and Respiratory Medicine ,Oncology ,education.field_of_study ,medicine.medical_specialty ,Multivariate analysis ,Adjuvant chemotherapy ,business.industry ,Population ,medicine.disease ,Complete resection ,Vascular invasion ,Internal medicine ,medicine ,Immunohistochemistry ,Surgery ,Stage (cooking) ,Cardiology and Cardiovascular Medicine ,education ,business ,Lung cancer - Abstract
Objectives: The aim of this study was to assess the significance of microscopic vascular invasion (MVI) in a population of completely resected patients with non-small-cell lung cancer (NSCLC), along with an analysis of impact of the MVI and clinicopathological factors on recurrence and survival. Methods: From September 2002 to December 2010, 1230 patients with NSCLC received complete resection at our institution. MVI was ascertained using histopathological and immunohistochemical techniques. Overall survival (OS) and disease-free survival (DFS) were estimated using the Kaplan–Meier method. We performed multivariate analyses to determine the independent prognostic factors. Results: MVI was observed in 448 patients (36.4%). Prevalence of MVI was lower in Stage I cases than in higher stage cases (P < 0.001). The presence of MVI was associated with DFS (P< 0.001, 3-year DFS: 87.1% in MVI-positive vs 64.3% in MVI-negative) and with OS (P< 0.001). Especially in Stage IB patients, who often receive oral anticancer agents as adjuvant chemotherapy in our institution, the presence of MVI was associated with DFS (P < 0.001, 3-year DFS: 85.4% in MVI-positive vs 69.3% in MVI-negative) and with OS (P = 0.039). In a multivariate survival analysis, The significant indicator of poor DFS was MVI (P< 0.001, CI 1.61-2.96), pulmonary metastases (P < 0.001, CI 1.49-2.98), pleural invasion (P = 0.007, CI 1.04-1.27), tumour size (P < 0.001, CI 1.01-1.02), and CEA level (P= 0.002, CI 1.00-1.01), although adjuvant chemotherapy has no significant relationship with DFS (P = 0.60). Conclusions: The finding of MVI in NSCLC is frequent. MVI correlates with tumour stages. The presence of MVI is an independent negative prognostic factor on both DFS and OS. Patients with these predictive factors of recurrence may be good candidates for intensive adjuvant chemotherapy. Disclosure: No significant relationships.
- Published
- 2014
35. Pulmonary hamartoma diagnosed by convex probe endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA)
- Author
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Kazutoshi Isobe, Fumitomo Sato, Sakae Homma, Kazutoshi Shibuya, Yoichiro Okubo, Yoshinobu Hata, Aki Mitsuda, Shoji Takahashi, Shuichi Sasamoto, Kazuyoshi Tamaki, and Keigo Takagi
- Subjects
Ebus tbna ,Male ,medicine.medical_specialty ,Lung Neoplasms ,business.industry ,Hamartoma ,Biopsy, Fine-Needle ,Tracheal wall ,General Medicine ,medicine.disease ,Endosonography ,Pulmonary Hamartoma ,Cartilage cells ,Bronchoscopy ,Internal Medicine ,Medicine ,Humans ,Radiology ,Endobronchial ultrasound ,business ,Hilar Mass ,Stone wall ,Aged - Abstract
A 71-year-old man with a right hilar mass shadow was referred to our department. Chest computed tomography showed a small fatty area inside. Convex probe endobronchial ultrasound (CP-EBUS) images revealed a heterogeneous low-echoic mass, resembling a stone wall and showing a smooth sliding movement along the tracheal wall during respiration. Transbronchial needle aspiration (EBUS-TBNA) was performed and cartilage cells were identified, compatible with the presence of a hamartoma. The patient requested follow-up without surgical intervention. CP-EBUS images are easier to interpret than other methods for monitoring respiratory dynamics. We conclude that CP-EBUS is a useful addition to techniques both for non-invasive imaging as well as guiding pathological examination.
- Published
- 2010
36. Continuous paravertebral block using a thoracoscopic catheter-insertion technique for postoperative pain after thoracotomy: a retrospective case-control study.
- Author
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Yoshikane Yamauchi, Mitsuhiro Isaka, Kamon Ando, Keita Mori, Hideaki Kojima, Tomohiro Maniwa, Shoji Takahashi, Eiji Ando, Yasuhisa Ohde, Yamauchi, Yoshikane, Isaka, Mitsuhiro, Ando, Kamon, Mori, Keita, Kojima, Hideaki, Maniwa, Tomohiro, Takahashi, Shoji, Ando, Eiji, and Ohde, Yasuhisa
- Subjects
PARAVERTEBRAL anesthesia ,THORACOTOMY ,THORACIC arteries ,SURGICAL complications ,POSTOPERATIVE pain ,DISEASES ,AMIDES ,CATHETERIZATION ,LOCAL anesthetics ,NERVE block ,THORACOSCOPY ,PAIN measurement ,TREATMENT effectiveness ,RETROSPECTIVE studies ,CASE-control method - Abstract
Background: Thoracic epidural analgesia (EDA) is the gold standard for pain control after thoracotomy. However, because of its severe side effects, it is contraindicated in patients taking anticoagulant or antiplatelet drugs. In addition, some patients' anatomy can make epidural catheter insertion challenging. We therefore investigated the safety and efficacy of paravertebral block (PVB) using a thoracoscopic insertion technique, which avoids damage to the parietal pleura, for postoperative pain after thoracotomy.Methods: Patients who underwent thoracotomy with thoracic PVB in our hospital between March 2013 and March 2014 were examined retrospectively. Prior to creating the thoracotomy incision, a catheter for PVB was inserted percutaneously into the paravertebral space under thoracoscopic guidance. A matched-pair control group was selected at a 1:2 ratio from patients who underwent thoracotomy with thoracic EDA in our hospital from April 2011 to February 2013. Pain control and side effects were compared between groups and the results statistically analyzed.Results: Thoracic PVB was performed in 56 patients during this period, and 112 patients were selected as matched controls. Numeric Rating Scale scores on postoperative day 2 did not differ significantly between the PVB group (3.25 ± 1.80) and the EDA group (3.56 ± 2.05) (p = 0.334). In terms of side effects, urinary retention occurred less frequently in thoracic PVB patients (p = 0.03).Conclusion: Under the conditions of the present study, continuous thoracic PVB was at least as effective as epidural analgesia for postoperative pain control after thoracotomy with lung resection. [ABSTRACT FROM AUTHOR]- Published
- 2017
- Full Text
- View/download PDF
37. Ethics: Moral issues of human-non-human primate neural grafting
- Author
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Mark, Greene, Kathryn, Schill, Shoji, Takahashi, Alison, Bateman-House, Tom, Beauchamp, Hilary, Bok, Dorothy, Cheney, Joseph, Coyle, Terrence, Deacon, Daniel, Dennett, Peter, Donovan, Owen, Flanagan, Steven, Goldman, Henry, Greely, Lee, Martin, Earl, Miller, Dawn, Mueller, Andrew, Siegel, Davor, Solter, John, Gearhart, Guy, McKhann, and Ruth, Faden
- Subjects
Animal Experimentation ,Moral Obligations ,Neurons ,Primates ,Transplantation Chimera ,Advisory Committees ,Transplantation, Heterologous ,Brain ,Morals ,Cell Line ,Ethics, Research ,Mental Processes ,Animals ,Humans ,Stem Cell Transplantation - Published
- 2005
38. Degradation of double-walled polymer microspheres of PLLA and P(CPP:SA)20:80. II. In vivo degradation
- Author
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Kathleen J. (Pekarek) Leach, Shoji Takahashi, and Edith Mathiowitz
- Subjects
Ethylene Oxide ,Drug Carriers ,Calorimetry, Differential Scanning ,Polymers ,Polyesters ,Biophysics ,Sterilization ,Bioengineering ,Biocompatible Materials ,Microspheres ,Rats ,Biomaterials ,Molecular Weight ,Rats, Sprague-Dawley ,Implants, Experimental ,Mechanics of Materials ,Spectroscopy, Fourier Transform Infrared ,Ceramics and Composites ,Microscopy, Electron, Scanning ,Animals ,Lactic Acid ,Decanoic Acids - Abstract
Double-walled (DW) polymer microspheres with a core of poly(1,3-bis-(p-carboxyphenoxy propane)-co-(sebacic anhydride)20:80 (P(CPP:SA)20:80) and an external coat of poly(L-lactic acid) (PLLA) were implanted subcutaneously and intramuscularly and were allowed to degrade for up to 6 months. The tissue surrounding the implant was fixed and sectioned for histological evaluation by light and scanning electron microscopy. The remaining polymer was extracted with chloroform and analyzed by gel permeation chromatography (G PC), Fourier-transform infrared (FTIR) spectroscopy, and differential scanning calorimetry (DSC). The inner core of the more hydrolytically labile P(CPP:SA)20:80 degraded first, becoming more granular over time. The PLLA coating showed no changes morphologically. The DW microspheres induced a stronger inflammatory response during the first week than did the SW PLLA microspheres, but this resolved by the second week. The SW PLLA microspheres showed no changes by SEM or optical microscopy. No differences in degradation were seen between samples implanted subcutaneously and those implanted intramuscularly. In vivo degradation was correlated to the results of an in vitro degradation study published as the first paper in this two paper series.
- Published
- 1998
39. Moral Issues of Human-Non-Human Primate Neural Grafting
- Author
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Terrence W. Deacon, Tom L. Beauchamp, Dawn Mueller, Steven A. Goldman, Dorothy L. Cheney, Shoji Takahashi, Henry T. Greely, Owen Flanagan, Alison Bateman-House, Andrew W. Siegel, Hilary Bok, Davor Solter, Earl K. Miller, John D. Gearhart, Lee J. Martin, Kathryn E. Schill, Joseph T. Coyle, Guy M. McKhann, Daniel C. Dennett, Mark Greene, Peter J. Donovan, and Ruth R. Faden
- Subjects
Transplantation ,Research ethics ,Multidisciplinary ,Non human primate ,Neural grafting ,Cognition ,Transplantation Chimera ,Animal testing ,Psychology ,Neuroscience ,humanities ,Neural stem cell - Abstract
The scientific, ethical, and policy issues raised by research involving the engraftment of human neural stem cells into the brains of nonhuman primates are explored by an interdisciplinary working group in this [Policy Forum][1]. The authors consider the possibility that this research might alter the cognitive capacities of recipient great apes and monkeys, with potential significance for their moral status. [1]: http://www.sciencemag.org/cgi/content/full/309/5733/385
- Published
- 2005
40. Abstract 37: Multiplexed mutational profiling of Japanese lung adenocarcinoma patients for personalized cancer therapy
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Yasuhisa Ode, Takashi Nakajima, Masakuni Serizawa, Mitsuhiro Isaka, Nobuyuki Yamamoto, Hirotsugu Kenmotsu, Masaru Watanabe, Toshiaki Takahashi, Akane Naruoka, Tateaki Naito, Akira Ono, Tetsuhiko Taira, Yasuhiro Koh, Shoji Takahashi, Junko Suzuki, and Masahiro Endo
- Subjects
Neuroblastoma RAS viral oncogene homolog ,Oncology ,Cancer Research ,medicine.medical_specialty ,Pathology ,biology ,business.industry ,medicine.disease ,medicine.disease_cause ,Fusion gene ,Internal medicine ,Genotype ,medicine ,biology.protein ,Adenocarcinoma ,PTEN ,KRAS ,business ,Lung cancer ,Genotyping - Abstract
Background: Integration of genotype-based stratification into the lung cancer clinic is essential to implement the personalized medicine for patients with lung adenocarcinoma. Thus we have developed a multiplexed tumor genotyping panel for detecting somatic mutations relevant to molecular targeted therapies for lung cancer. The mutation profile data are communicated to clinicians to assign patients to appropriate therapy and/or clinical trials. Methods: Multiplexed tumor genotyping panel was developed to assess 23 mutations in 9 genes (EGFR, KRAS, BRAF, PIK3CA, NRAS, MEK1, AKT1, PTEN and HER2), 5 genes amplifications (EGFR, MET, PIK3CA, FGFR1 and FGFR2), and 5 fusion genes (EML4-ALK, CD74-ROS1, SLC34A2-ROS1, KIF5B-RET and CCDC6-RET) using pyrosequencing plus capillary electrophoresis, qRT-PCR, and multiplex RT-PCR, respectively. A written informed consent was obtained upfront from all patients enrolled into this study. Surgically resected tissues, tumor biopsies, pleural effusions and/or pericardial effusions from 280 patients were collected between July 2011 and July 2012 and used for tumor genotyping. Results: Somatic mutations were detected in 52.9% (148/280) of all patients. The most common mutation detected in this study was EGFR mutation (35.4%, 99) followed by KRAS mutation (10.4%, 29). EGFR L858R (52.5%) and KRAS G12C (44.8%) was the most frequent among EGFR and KRAS mutations, respectively. Other detected mutations were PIK3CA mutation (2.5%), PIK3CA amplification (2.5%), EGFR amplification (2.5%), MET amplification (2.1%), EML4-ALK fusion gene (1.4%), BRAF mutation (1.1%), NRAS mutation (1.1%), HER2 mutation (1.1%), MEK1 mutation (0.7%), AKT1 mutation (0.7%), KIF5B-RET fusion gene (0.4%), CD74-ROS1 fusion gene (0.4%) and FGFR1 amplification (0.4%). EGFR tyrosine kinase inhibitor (EGFR-TKI) was administered to 71.9% (41/57) of previously untreated patients who harbor EGFR activating mutations. Among those treated with EGFR-TKIs, simultaneous mutations in other genes with EGFR mutations were detected in 21.9% (9/41). Response rate of EGFR-TKIs in patients with simultaneous mutations (44.4%) was lower than that in patients with EGFR mutation alone (68.8%), suggesting that additional mutations may play some role in evading oncogenic signaling blockade. EGFR mutations were detected less frequently in smokers than in never-smokers (25.1% vs 60.5%, p Conclusions: We have established the multiplexed tumor genotyping panel and this should be incorporated into lung cancer clinical practice to facilitate personalized cancer medicine. Citation Format: Masakuni Serizawa, Yasuhiro Koh, Hirotsugu Kenmotsu, Mitsuhiro Isaka, Akane Naruoka, Junko Suzuki, Masaru Watanabe, Masahiro Endo, Takashi Nakajima, Shoji Takahashi, Yasuhisa Ode, Tateaki Naito, Tetsuhiko Taira, Akira Ono, Toshiaki Takahashi, Nobuyuki Yamamoto. Multiplexed mutational profiling of Japanese lung adenocarcinoma patients for personalized cancer therapy. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 37. doi:10.1158/1538-7445.AM2013-37
- Published
- 2013
41. Prospective genetic profiling of squamous cell lung cancer and adenosquamous carcinoma in Japanese patients by multitarget assays.
- Author
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Hirotsugu Kenmotsu, Masakuni Serizawa, Yasuhiro Koh, Mitsuhiro Isaka, Toshiaki Takahashi, Tetsuhiko Taira, Akira Ono, Tomohiro Maniwa, Shoji Takahashi, Keita Mori, Masahiro Endo, Masato Abe, Isamu Hayashi, Takashi Nakajima, Yasuhisa Ohde, and Nobuyuki Yamamoto
- Subjects
LUNG cancer ,CANCER treatment ,SQUAMOUS cell carcinoma ,JAPANESE people ,CANCER invasiveness ,LONGITUDINAL method ,DISEASES - Abstract
Background: Despite considerable recent progress in the treatment of lung adenocarcinoma, there has been little progress in the development of efficacious molecular targeted therapies for squamous cell lung cancer. In addition to the recent comprehensive genome-wide characterization of squamous cell lung cancer, it is also important to genotype this form of cancer. We therefore conducted the Shizuoka Lung Cancer Mutation Study to analyze driver mutations in patients with thoracic malignancies. Here we report the results of genotyping in patients with squamous cell lung cancer. Methods: Based on the biobanking system, in conjunction with the clinic and pathology lab, we developed a genotyping panel designed to assess 24 mutations in 10 genes (EGFR, KRAS, BRAF, PIK3CA, NRAS, MEK1, AKT1, PTEN, HER2 and DDR2), EGFR, MET, PIK3CA, FGFR1 and FGFR2 copy numbers, and EML4-ALK and ROS1 translocations, using pyrosequencing plus capillary electrophoresis, quantitative polymerase chain reaction (PCR) and reverse-transcription PCR, respectively. Results: A total of 129 patients with squamous cell lung cancer and adenosquamous carcinoma were enrolled in this study between July 2011 and November 2012. We detected genetic alterations in 40% of all cases. Gene alterations included: EGFR mutations, 6%; KRAS mutations, 4%; PIK3CA mutations, 13%; NRAS mutations, 1%; KIF5b-RET fusion gene, 1%; EGFR copy number gain, 5%; PIK3CA copy number gain, 15%; and FGFR1 copy number gain, 5%. Twelve patients (9%) harbored simultaneous genetic alterations. Genetic alterations were detected more frequently in surgically-resected, snap-frozen samples than in formalin-fixed, paraffin-embedded samples (50% vs. 29%). In addition, patients aged ≤70 years old and never-smokers showed high frequencies of genetic alterations. Conclusions: This study represents one of the largest prospective tumor-genotyping studies to be performed in Asian patients with squamous cell lung cancer. These results suggest that incorporation of genetic profiling into lung cancer clinical practice may facilitate the administration of personalized cancer treatments in patients with squamous cell lung cancer. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
42. Heat propagation in differential thermal analysis system using fiber-optics technology
- Author
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N. Kobayashi, K.-I. Noda, Shoji Takahashi, O. Akimoto, and Teruo Kimura
- Subjects
Materials science ,Optical fiber ,business.industry ,Propagation delay ,Temperature measurement ,law.invention ,Optics ,Interference (communication) ,Fiber optic sensor ,law ,Thermometer ,Differential thermal analysis ,Electrical and Electronic Engineering ,Thermal analysis ,business ,Instrumentation - Abstract
A very highly sensitive differential thermal analysis system is constructed by using optical-fiber sensor technology. Measurement of small temperature differences is reliably performed by detecting the phase differences with interference light and using a thermally symmetric configuration. In particular, temperature response analysis under heat propagation delay conditions, which should be considered when heat inputs are small and rapid, is made. The high sensitivity for temperature differences of an optical fiber thermometer is also experimentally demonstrated. Temperature responses for continuous and pulsed heat inputs are formulated and used to analyze experimental results on this small differential thermal analysis system under various conditions. >
- Published
- 1989
43. Color of human teeth, caries resistance and enamel solution rate
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Shoji Takahashi, Keiichi Kawano, Ryozo Hirayasu, Yoshihiro Terada, Takae Himeno, and Takako Sakai
- Subjects
stomatognathic diseases ,Solution rate ,Materials science ,stomatognathic system ,Enamel paint ,business.industry ,visual_art ,visual_art.visual_art_medium ,Acid resistance ,Dentistry ,Maxillary central incisor ,General Medicine ,business - Abstract
Labial surfaces of maxillary central incisors were analyzed for the color and the acid resistance using as materials 130 teeth of dental students. Color of the teeth was measured intraorally with a fiber-colorimeter and was expressed with Adams' L, a, b. The enamel solubility in vivo was measured by applying a paper disk containing lactate buffer to the enamel surface. A weak but significant correlation between the enamel solubility and Adams' b values was found (r=0.314). This is supportive evidence for the clinical view that yellowish teeth are caries-resistant.
- Published
- 1984
44. Distribution of carbon tetrachloride in rat liver and its urinary metabolites
- Author
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Shoji Takahashi, Kunisuke Nagamatsu, Goro Urakubo, and Takayuki Nakahama
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chemistry.chemical_compound ,Chromatography ,Chemistry ,Urinary system ,Rat liver ,Carbon tetrachloride ,Distribution (pharmacology) ,Toxicology - Published
- 1988
45. Bacterial soft rot in red turnip, Brassica campestris L. (rapifera group) 'cv. Atsumi-kabu', grown in burnt fields
- Author
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Jiro Togashi, Minoru Shibata, and Shoji Takahashi
- Subjects
Bacterial soft rot ,Yellow discoloration ,biology ,Botany ,Brassica ,food and beverages ,Wilting ,Erwinia ,biology.organism_classification ,Bacteria - Abstract
The red turnip, Brassica campestris L. (rapifera group), “cv. Atsumi-kabu” grown in burnt fields in Atsumi-machi, Yamagata Prefecture, Japan, showed wilting followed by yellow discoloration of leaves from September to October in 1986. A few small, water-soaked soft-rot lesions were formed on the bases of leaf petioles and the roots. They gradually developed, and finally whole plants decayed. Soft-rot Erwinia-like bacteria were predominantly isolated from the diseased plants. Pathogenicities and bacteriological characteristics of the isolates were identical with those of Erwinia carotovora subsp. carotovora. From these results, the present symptoms on the red turnip, “Atsumi-kabu”, was suggested to be caused by E. carotovora subsp. carotovora. This is the first report on the occurrence of soft rot on the vegetables in burnt fields in Japan.
- Published
- 1988
46. Studies on Enzymatic Determination of Sugars in Foods Part I
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Goro Kuwata, Teruhiko Morimoto, and Shoji Takahashi
- Subjects
Part iii ,Chemistry (miscellaneous) ,Chemistry ,Medicine (miscellaneous) ,Food science ,Food Science ,Biotechnology - Abstract
(1) レゾルシン反応において,呈色液の褪色性は室温で1時間放置すると約3%, 2時間で5.8%であった. (2) アンスロン反応において,呈色液の褪色性は室温で1時間放置しても,ほとんど褪色を認めないが,その後は徐々に褪色を行ない, 3時間で約2%の裾色が認められた. (3) グルコースをglucose oxidaseで酸化して,グルコン酸とすることにより, 33倍程度のグルコースが存在してもフラクトースの安定した比色定量が可能である. (4) アンスロン反応によるフラクトースの検量線は,実験計画法より2次式とするのが適当である. (5) 検量線の多項式および信頼区間が定まったが,後者はこの実験値から推定する場合のもので,従ってこの曲線を利用して新しい測定値から推定する場合には,その測定値の誤差が加わることになる. (6) 検量線の検討で測定回の影響が有意なので,試料と同時に標準試料を発色すれば,上の多項式だけで推定するより精度を向上すると思われるが,しかし分析する人,使用器具,試薬等が同一であれば,それほど神経質にならず, 1本の検量曲線で,ある期間は間に合うのではないかと思われる.もちろん必要な精度を考慮した上である. (7) グルコースをglucose oxidaseで33倍程度のグルコースが,シュクロースをカラム・クロマトグラフィーで除くことにより,フラクトースを平均99.7±0.94%の精度で定量を行なうことができる. (8) 本報は食品中の各種糖類の定量の一環として行なったものであるが,第1報と異なり,カーボンカラム・クロマトグラフィーを使用するところから,このクロマトグラフィーで水にて溶出してくる糖(主としてグルコース,フラクトース以外の単糖類)が存在する場合は少し問題がある.しかし現在一般の食品の場合は,そのような糖が存在することは非常にまれなことと考えられる(例外としてガラクトース添加食品).
- Published
- 1966
47. Studies on Protective Coating. XV
- Author
-
Shoji Takahashi, Shuzo Kishi, Tadao Ida, and Isamu Utsumi
- Subjects
Pharmacology ,Chemistry ,Pharmaceutical Science - Published
- 1962
48. Copolymerization of Vinyl Chloride with Acrolein and Crotonaldehyde
- Author
-
Shoji Takahashi, Minoru Imoto, and Kiichi Takemoto
- Subjects
chemistry.chemical_compound ,chemistry ,Acrolein ,Copolymer ,Organic chemistry ,General Medicine ,Crotonaldehyde ,Vinyl chloride - Abstract
塩化ビニルとアクロレインおよびクロトンアルデヒドとの共重合を60℃ , 主としてテトラヒドロフランを溶媒として検討した。塩化ビニル・アクロレインの共重合ではアクロレインの方が, また塩化ビニル・クロトンアルデヒドの共重合では逆に塩化ビニルの方が共重合体中に導入されやすいこと, また重合速度は前者の場合アクロレイン分率の増すとともに大となるが, 後者では逆にクロトンアルデヒド分率の増すとともに小となることが見い出された。塩化ビニル(M1) とアク質レイン(M2) およびクロトンアルデヒド(M2') との単量体反応性比は60℃ においてそれぞれr1=0.04, r2=5.40; r1=1.93, r2'=0.02 ともとめられた。塩化ビニル・クロトンアルデヒド共重合体は可溶性でアルデヒド基をふくむので, さらにアミンやフェニルヒドラジンなどとの反応を行なった。
- Published
- 1968
49. Studies on the Direct Resolution of Optical Isomers. I
- Author
-
Masumi Yagyu, Takeo Ishiguro, Shoji Takahashi, and Jun Mitsui
- Subjects
Pharmacology ,chemistry.chemical_compound ,Resolution (mass spectrometry) ,chemistry ,Stereochemistry ,Pharmaceutical Science ,1,3-Propanediol ,Solubility - Published
- 1960
50. HIGH MOLECULAR DERIVATIVES OF VITAMIN A
- Author
-
Shoji Takahashi, Isamu Utsumi, and Tadao Ida
- Subjects
Vitamin ,Chromatography ,Infrared Rays ,Ultraviolet Rays ,Research ,Fatty Acids ,General Medicine ,Methacrylate ,Keto Acids ,Styrene ,chemistry.chemical_compound ,chemistry ,Methacrylic acid ,Magnesium bromide ,Polymer chemistry ,Organic chemistry ,Methyl methacrylate ,Vitamin A ,Methyl acrylate ,Acrylic acid - Abstract
Powdery polymers of vitamin A esters were synthesized by polymerizing acrylic and methacrylic ester of vitamin A under the presence of α, α′-azo-bis-isobutyronitrile as a catalyst at 70° or of n-butyl lithium in hexane at -10 to -20°. The polymer failed to be obtained when phenyl magnesium bromide was used as a catalyst. Crotonic and undecylenic esters of vitamin A were not polymerized by the above methods. Powdery copolymers of vitamin A esters with acrylic acid, methacrylic acid, methyl acrylate, methyl methacrylate, styrene or 2-vinyl-5-ethyl-pyridine were also synthesized by the same methods.
- Published
- 1963
Catalog
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