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2. Citizen Science Astronomy with a Network of Small Telescope: The Launch and Deployment of JWST

Author

Lambert, R. A., Marchis, F., Asencio, J., Blaclard, G., Sgro, L. A., Giorgini, J. D., Plavchan, P., White, T., Verveen, A., Goto, T., Kuossari, P., Sethu, N., Loose, M. A., Will, S., Sibbernsen, K., Pickering, J. W., Randolph, J., Fukui, K., Huet, P., Guillet, B., Clerget, O., Stahl, S., Yoblonsky, N., Lauvernier, M., Matsumura, T., Yamato, M., Laugier, J. M., Brodt-Vilain, O., Espudo, A., Kukita, R., Iida, S., Kardel, S., Green, D., Tikkanen, P., Douvas, A., Billiani, M., Knight, G., Ryno, M., Simard, G., Knight, R., Primm, M., Wildhagen, B., Poncet, J., Frachon, T., Shimizu, M., Jackson, A., Parker, B., Redfern, G., Nikiforov, P., Friday, E., Lincoln, K., Sweitzer, J., Mitsuoka, R., Cabral, K., Katterfeld, A., and Fairfax, M.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Earth and Planetary Astrophysics
Abstract

We present a coordinated campaign of observations to monitor the brightness of the James Webb Space Telescope (JWST) as it travels toward the second Earth-Sun Lagrange point and unfolds using the network ofUnistellar digital telescopes. Those observations collected by citizen astronomers across the world allowed us to detect specific phases such as the separation from the booster, glare due to a change of orientation after a maneuver, the unfurling of the sunshield, and deployment of the primary mirror. After deployment of the sunshield on January 6 2022, the 6-h lightcurve has a significant amplitude and shows small variations due to the artificial rotation of the space telescope during commissionning. These variations could be due to the deployment of the primary mirror or some changes in orientation of the space telescope. This work illustrates the power of a worldwide array of small telescopes, operated by citizen astronomers, to conduct large scientific campaigns over a long timeframe. In the future, our network and others will continue to monitor JWST to detect potential degradations to the space environment by comparing the evolution of the lightcurve., Comment: 15 pages, 13 figures and 2 tables, SPIE Ground-based and Airborne Telescopes IX, AS22 SPIE Astronomical Telescopes + Instrumentation, 12182-144

Published
2022

4. Visual Outcome and Treatment Frequency of Anti-VEGF Therapy Using the Treat-and-Extend and Treatment Cessation Regimen for Exudative Age-Related Macular Degeneration and Pachychoroid Neovasculopathy

Author

Kinoshita T, Mori J, Hatanaka A, Shimizu M, and Imaizumi H

Subjects
age-related macular degeneration, pachychoroid neovasculopathy, anti-vascular endothelial growth factor, treat-and-extend regimen, treatment cessation, Ophthalmology, RE1-994
Abstract

Takamasa Kinoshita, Junya Mori, Akira Hatanaka, Miho Shimizu, Hiroko Imaizumi Department of Ophthalmology, Sapporo City General Hospital, Sapporo, JapanCorrespondence: Takamasa KinoshitaDepartment of Ophthalmology, Sapporo City General Hospital, 1-1, N-11, W-13, Chuoku, Sapporo, 060-8604, JapanTel +81 11 726 2211Fax +81 11 726 9541Email knst129@gmail.comPurpose: To report the results of anti-vascular endothelial growth factor (VEGF) therapy using treat-and-extend (TAE) and treatment cessation regimens for exudative age-related macular degeneration (AMD) and pachychoroid neovasculopathy (PN).Methods: We retrospectively studied 101 treatment-naïve eyes of 101 patients with exudative AMD and PN that underwent anti-VEGF therapy using TAE and treatment cessation regimen with a follow-up period of ≥ 12 months. Best-corrected visual acuity (BCVA), treatment frequency, and number of eyes with successful treatment cessation were measured. Successful treatment cessation was defined as dry macula retention without treatment for > 16 weeks after the last injections. Factors related to the successful treatment cessation were evaluated.Results: BCVA was maintained at the last visit with a mean follow-up period of 49.9 ± 26.9 months. The injection number decreased from 6.8 ± 2.31 at the first year to 3.7 ± 3.64 at the fifth year. At the last visit, 48 (47.5%) eyes were being treated at an interval of ≥ 12 weeks or were under treatment cessation. Successful treatment cessation during the follow-up period and at the last visit were achieved in 56 (55.4%) and 27 (26.7%) eyes, with a median treatment-free period of 66 and 126 weeks, respectively. Good early treatment response and a small recurrence number were associated with successful treatment cessation at the last visit.Conclusion: Patients with good early response to treatment and fewer recurrences may achieve treatment cessation. This information could help physicians predict the achievement of treatment cessation for a considerable period.Keywords: age-related macular degeneration, pachychoroid neovasculopathy, anti-vascular endothelial growth factor, treat-and-extend regimen, treatment cessation

Published
2021

6. Effects of Polymorphisms in the Serotonin Transporter Promoter-Linked Polymorphic Region on Postthoracotomy Pain Severity

Author

Kimura A, Yamasaki H, Ishii H, Yoshida H, Shimizu M, and Mori T

Subjects
5-httlpr, pain modulation, numerical rating scale, Medicine (General), R5-920
Abstract

Aya Kimura,1 Hiroyuki Yamasaki,1 Haruka Ishii,2 Hisako Yoshida,2 Motoko Shimizu,3 Takashi Mori1 1Department of Anesthesiology, Osaka City University Graduate School of Medicine, Osaka City, Osaka, Japan; 2Department of Medical Statistics, Osaka City University Graduate School of Medicine, Osaka City, Osaka, Japan; 3Department of Anesthesiology, Sumitomo Hospital, Osaka City, Osaka, JapanCorrespondence: Aya KimuraDepartment of Anesthesiology, Osaka City University Graduate School of Medicine, 1-5-7 Asahimachi, Abeno-ku, Osaka City, Osaka, 545-8586, JapanTel +81-6-6645-2186Fax +81-6-6645-2489Email aya1226kimura@gmail.comPurpose: Serotonin (5-HT) is highly associated with pain modulation. The human 5-HT transporter (5-HTT) gene (SLC6A4) features several polymorphisms in its promoter region (5-HTTLPR) that affect the 5-HTT expression. The S allele of 5-HTTLPR induces low 5-HT tone, and it may influence the modulation of chronic pain. Meanwhile, pain occurs in 40– 50% of patients after thoracic surgery, and its mechanism remains under investigation. This study assessed the role of 5-HTTLPR polymorphisms in postthoracotomy pain severity.Patients and Methods: A total of 178 patients undergoing pneumonectomy were enrolled. The genotypes of 5-HTTLPR were divided into two groups: S/S group and S/L or L/L group. Linear mixed-effects models were used to assess the association between 5-HTTLPR genotypes and the numerical rating scale (NRS) score change over time.Results: Among the participants, data were obtained for 162 patients. The genotype distribution was as follows: S/S, 67.3%; S/L or L/L, 32.7%. No significant difference in patient characteristics was found between the genotype groups. There was no significant interaction between the 5-HTTLPR genotypes and the NRS score change over time (p = 0.842).Conclusion: Polymorphisms in 5-HTTLPR were not associated with postthoracotomy pain severity.Keywords: 5-HTTLPR, pain modulation, numerical rating scale

Published
2021

7. Digital-photonic synthesis of ultra-low noise tunable signals from RF to 100 GHz

Author

Fortier, T. M., Rolland, A., Quinlan, F., Baynes, F. N., Metcalf, A. J., Hati, A., Ludlow, A., Hinkley, N., Shimizu, M., Ishibashi, T., Campbell, J. C., and Diddams, S. A.

Subjects
Physics - Instrumentation and Detectors
Abstract

The demand for higher data rates and better synchronization in communication and navigation systems necessitates the development of new wideband and tunable sources with noise performance exceeding that provided by traditional oscillators and synthesizers. Precision synthesis is paramount for providing frequency references and timing in a broad range of applications including next-generation telecommunications, high precision measurement, and radar and sensing. Here we describe a digital-photonic synthesizer (DPS) based on optical frequency division that enables the generation of widely tunable signals from near DC to 100 GHz with a fractional frequency instability of 1 part in 10^15. The spectral purity of the DPS derived signals represents an improvement in close-to-carrier noise performance over the current state-of-the-art of nearly 7 orders of magnitude in the W-band (100 GHz), and up to 5 orders of magnitude in the X-band (10 GHz).

Published
2015

8. Effect of Gold Nanoparticle Radiosensitization on Plasmid DNA Damage Induced by High-Dose-Rate Brachytherapy

Author

Yogo K, Misawa M, Shimizu M, Shimizu H, Kitagawa T, Hirayama R, Ishiyama H, Furukawa T, and Yasuda H

Subjects
gold nanoparticles, high-dose-rate brachytherapy, dna damage, radiosensitization, 192ir γ-rays, positively charged nanoparticles, Medicine (General), R5-920
Abstract

Katsunori Yogo,1 Masaki Misawa,2 Morihito Shimizu,2 Hidetoshi Shimizu,3 Tomoki Kitagawa,3 Ryoichi Hirayama,4 Hiromichi Ishiyama,5 Takako Furukawa,1 Hiroshi Yasuda6 1Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan; 2Health and Medical Research Institute, National Institute of Advanced Industrial Science & Technology (AIST), Tsukuba, Ibaraki, Japan; 3Department of Radiation Oncology, Aichi Cancer Center Hospital, Nagoya, Aichi, Japan; 4National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology (QST), Chiba-shi, Chiba, Japan; 5Graduate School of Medical Science, Kitasato University, Sagamihara, Kanagawa, Japan; 6Department of Radiation Biophysics, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, JapanCorrespondence: Katsunori YogoNagoya University Graduate School of Medicine, 1-1-20 Daiko-Minami, Higashi-Ku, Nagoya, Aichi 461-8673, JapanTel +81 52 719 1103Fax +81 52 719 3172Email yogo@met.nagoya-u.ac.jpPurpose: Gold nanoparticles (AuNPs) are candidate radiosensitizers for medium-energy photon treatment, such as γ-ray radiation in high-dose-rate (HDR) brachytherapy. However, high AuNP concentrations are required for sufficient dose enhancement for clinical applications. Here, we investigated the effect of positively (+) charged AuNP radiosensitization of plasmid DNA damage induced by 192Ir γ-rays, and compared it with that of negatively (−) charged AuNPs.Methods: We observed DNA breaks and reactive oxygen species (ROS) generation in the presence of AuNPs at low concentrations. pBR322 plasmid DNA exposed to 64 ng/mL AuNPs was irradiated with 192Ir γ-rays via HDR brachytherapy. DNA breaks were detected by observing the changes in the form of the plasmid and quantified by agarose gel electrophoresis. The ROS generated by the AuNPs were measured with the fluorescent probe sensitive to ROS. The effects of positively (+) and negatively (−) charged AuNPs were compared to study the effect of surface charge on dose enhancement.Results: +AuNPs at lower concentrations promoted a comparable level of radiosensitization by producing both single-stranded breaks (SSBs) and double-stranded breaks (DSBs) than those used in cell assays and Monte Carlo simulation experiments. The dose enhancement factor (DEF) for +AuNPs was 1.3 ± 0.2 for SSBs and 1.5 ± 0.4 for DSBs. The ability of +AuNPs to augment plasmid DNA damage is due to enhanced ROS generation. While −AuNPs generated similar ROS levels, they did not cause significant DNA damage. Thus, dose enhancement using low concentrations of +AuNPs presumably occurred via DNA binding or increasing local +AuNP concentration around the DNA.Conclusion: +AuNPs at low concentrations displayed stronger radiosensitization compared to −AuNPs. Combining +AuNPs with 192Ir γ-rays in HDR brachytherapy is a candidate method for improving clinical outcomes. Future development of cancer cell-specific +AuNPs would allow their wider application for HDR brachytherapy.Keywords: gold nanoparticles, high-dose-rate brachytherapy, DNA damage, radiosensitization, 192Ir γ-rays, positively charged nanoparticles

Published
2021

9. Genuine Irregular Galaxies as a Relic of Building Blocks of Galaxies

Author

Terao, K., Taniguchi, Y., Kajisawa, M., Shioya, Y., Kobayashi, M. A. R., Matsuoka, K., Ikeda, H., Murata, K. L., Ichikawa, A., Shimizu, M., Niida, M., and Hamaguchi, E.

Subjects
Astrophysics - Astrophysics of Galaxies, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

In order to understand nature of building blocks of galaxies in the early universe, we investigate "genuine irregular galaxies (GIGs)" in the nearby universe. Here, GIGs are defined as isolated galaxies without regular structures (spheroid, bulge, disk, bar, spiral arm, and nucleus). Using the results of two excellent studies on galaxy morphology based on the Sloan Digital Sky Survey (SDSS), we obtain a sample of 66 irregular galaxies. We carry out new classification of them into GIGs and non-GIGs which have regular structure or show evidence for galaxy interaction, by using the SDSS Data Release 10 images. We then find that a half of these irregular galaxies (33/66) are GIGs and obtain an unambiguous sample of 33 GIGs for the first time. We discuss their observational properties by comparing them with those of elliptical, S0, spiral galaxies, and irregular galaxies without the GIGs. We find that our GIGs have smaller sizes, lower optical luminosities, bluer rest-frame optical colors, lower surface stellar mass densities, and lower gas metallicity than normal galaxies. All these properties suggest that they are in chemically and dynamically younger phases even in the nearby universe., Comment: submitted to the Astrophysical Journal on 21st October, 2013

Published
2013

11. Giant Chromospheric Anemone Jet Observed with Hinode and Comparison with Magnetohydrodynamic Simulations: Evidence of Propagating Alfven Waves and Magnetic Reconnection

Author

Nishizuka, N., Shimizu, M., Nakamura, T., Otsuji, K., Okamoto, T. J., Katsukawa, Y., and Shibata, K.

Subjects
Astrophysics
Abstract

Hinode discovered a beautiful giant jet with both cool and hot components at the solar limb on 2007 February 9. Simultaneous observations by the Hinode SOT, XRT, and TRACE 195 satellites revealed that hot (5x10^6 K) and cool (10^4 K) jets were located side by side and that the hot jet preceded the associated cool jet (1-2 minutes). A current-sheet-like structure was seen in optical (Ca IIH), EUV (195A), and soft X-ray emissions, suggesting that magnetic reconnection is occurring in the transition region or upper chromosphere. Alfven waves were also observed with Hinode SOT. These propagated along the jet at velocities of 200 km/s with amplitudes (transverse velocity) of 5-15 km/s and a period of 200 s. We performed two-dimensional MHD simulation of the jets on the basis of the emerging flux-reconnection model, by extending Yokoyama and Shibata's model. We extended the model with a more realistic initial condition (10^6 K corona) and compared our model with multiwavelength observations. The improvement of the coronal temperature and density in the simulation model allowed for the first time the reproduction of the structure and evolution of both the cool and hot jets quantitatively, supporting the magnetic reconnection model. The generation and the propagation of Alfven waves are also reproduced self-consistently in the simulation model., Comment: 12 pages, 3 figures

Published
2008
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12. Examination of biomarker expressions in sepsis-related DIC patients

Author

Shimizu M, Konishi A, and Nomura S

Subjects
DIC, sepsis, PDMP, sP-selectin, IL-6, TPO, Medicine (General), R5-920
Abstract

Michiomi Shimizu, Akiko Konishi, Shosaku Nomura First Department of Internal Medicine, Kansai Medical University, Hirakata, Japan Background: Disseminated intravascular coagulation (DIC) is the main cause of death among patients with sepsis. In particular, low platelet count is predictive of poor outcome. However, the significance of platelet activation in patients with sepsis-related DIC is poorly understood. To determine the characteristics of platelet-related abnormality in patients with sepsis-related DIC, we assessed the expression levels of several biomarkers.Methods: Plasma levels of biomarkers, including cytokines, chemokines, soluble selectins, platelet-derived microparticles (PDMPs), soluble vascular adhesion molecule 1, and high mobility group box protein 1 were measured by enzyme-linked immunosorbent assay at baseline and after 4, 7, 14, and 21 days of DIC treatment.Results: Differences in platelet activation and in the elevation of activated platelet-related PDMPs and of soluble P-selectin were seen between patients suffering from sepsis and hematologic malignancy with DIC. In addition, the elevation of interleukin (IL)-6 and thrombopoietin (TPO) was significant in sepsis patients with DIC. Furthermore, IL-6 and TPO promoted platelet activation in vitro.Conclusion: Assessment of PDMPs, sP-selectin, IL-6, and TPO may be beneficial in the primary prevention of multi-organ failure in sepsis patients with DIC. Keywords: disseminated intravascular coagulation, platelet activation, PDMP, sP-selectin, IL-6, TPO

Published
2018

16. Differences in the transcriptional immune response to Albugo candida between white rust resistant and susceptible cultivars in Brassica rapa L.

Author

Miyaji, N, Akter, MA, Shimizu, M, Mehraj, H, Doullah, MA-U, Dennis, ES, Chuma, I, Fujimoto, R, Miyaji, N, Akter, MA, Shimizu, M, Mehraj, H, Doullah, MA-U, Dennis, ES, Chuma, I, and Fujimoto, R

Abstract

Albugo candida causing white rust disease decreases the yield of Brassica rapa vegetables greatly. Resistant and susceptible cultivars in B. rapa vegetables have different immune responses against A. candida inoculation, however, the mechanism of how host plants respond to A. candida is still unknown. Using RNA-sequencing, we identified differentially expressed genes (DEGs) between A. candida inoculated [48 and 72 h after inoculation (HAI)] and non-inoculated samples in resistant and susceptible cultivars of komatsuna (B. rapa var. perviridis). Functional DEGs differed between the resistant and susceptible cultivars in A. candida inoculated samples. Salicylic acid (SA) responsive genes tended to be changed in their expression levels by A. candida inoculation in both resistant and susceptible cultivars, but different genes were identified in the two cultivars. SA-dependent systemic acquired resistance (SAR) involving genes were upregulated following A. candida inoculation in the resistant cultivar. Particular genes categorized as SAR that changed expression levels overlapped between A. candida and Fusarium oxysporum f. sp. conglutinans inoculated samples in resistant cultivar, suggesting a role for SAR in defense response to both pathogens particularly in the effector-triggered immunity downstream pathway. These findings will be useful for understanding white rust resistance mechanisms in B. rapa.

Published
2023

17. Characterization of FLOWERING LOCUS C 5 in Brassica rapa L.

Author

Akter, A, Kakizaki, T, Itabashi, E, Kunita, K, Shimizu, M, Akter, MA, Mehraj, H, Okazaki, K, Dennis, ES, Fujimoto, R, Akter, A, Kakizaki, T, Itabashi, E, Kunita, K, Shimizu, M, Akter, MA, Mehraj, H, Okazaki, K, Dennis, ES, and Fujimoto, R

Abstract

UNLABELLED: Brassica rapa L., which includes Chinese cabbage, turnip, and pak choi, has more complex flowering time regulation than does Arabidopsis thaliana due to the presence of multiple paralogous flowering time genes. FLOWERING LOCUS C (FLC) is one of the key genes regulating the flowering time, and B. rapa has four FLC paralogs. BrFLC5 on the reference genome is deemed a pseudogene because of a mutation (from G to A) in the splice site of the third intron, but there are some accessions with a G nucleotide in the splice site. In this study, we genotyped 310 B. rapa accessions and found that 19 had homozygous and 81 had heterozygous putative functional BrFLC5 alleles. Accessions of turnip showed the highest proportion with a functional BrFLC5 allele. BrFLC5 acts as a floral repressor when overexpressed in A. thaliana. The BrFLC5 expression level varied in pre-vernalized plants, and this transcriptional variation was not associated with the G/A polymorphism in the third intron. Three accessions having a higher BrFLC5 expression in pre-vernalized plants had a 584-bp insertion in the promoter region. Many regions homologous to this 584-bp sequence are present in the B. rapa genome, and this 584-bp inserted region has tandem duplications of an AT-rich sequence in its central region. The possibility that a high expression of a functional BrFLC5 could contribute to producing premature bolting-resistant lines in B. rapa vegetables is discussed. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11032-023-01405-0.

Published
2023

18. The role of salicylic acid responsive genes in disease resistance in Brassica rapa vegetable

Author

Akter, MA, Miyaji, N, Shimizu, M, Takasaki-Yasuda, T, Dennis, ES, Fujimoto, R, Akter, MA, Miyaji, N, Shimizu, M, Takasaki-Yasuda, T, Dennis, ES, and Fujimoto, R

Abstract

Salicylic acid (SA) is a plant hormone that regulates many stress responses and developmental processes including the plant immune response, thermogenesis, senescence, and abiotic stress responses. To identify SA responsive genes at the whole genome level, we performed RNA-sequencing analysis with and without SA treatment in two komatsuna cultivars (Brassica rapa var. perviridis). We identified 1,061 up- and 994 downregulated genes that overlapped between the two cultivars, and these genes were defined as B. rapa SA-induced genes (BrSAIGs) and B. rapa SA-suppressed genes (BrSASGs), respectively. In this study, we identified genes overlapping between BrSAIGs/BrSASGs and paired genes overlapping natural antisense transcripts (NATs) or intronic noncoding RNAs (incRNAs) in their encoding regions. Thirty-three mRNA/NAT pairs and three mRNA/incRNA pairs were identified. The transcriptional relationship between mRNAs and their paired NATs following SA treatment was examined, and two of four pairs showed a positive association of expression levels between mRNAs and their paired NATs. These results suggest that the transcriptional association of mRNAs and their paired NATs plays a role in SA response. Previously, SA treatment was performed by adding SA to the solid medium, but this method has limitations on the number of samples that can be assayed simultaneously. In this study, we sprayed SA on the samples, which is more high-throughput. The upregulation of all six genes that were shown to be upregulated following SA treatments on the medium, was found following spraying. Transcriptional induction was faster with SA spraying than by adding SA into the medium. These results indicate that SA spraying is applicable for further experiments.

Published
2023

21. Vascular endothelial factor C and D in patients with heart failure with preserved, mildly reduced, and reduced ejection fraction: the PREHOSP-CHF study

Author

Iguchi, M, primary, Wada, H, additional, Shinozaki, T, additional, Suzuki, M, additional, Ajiro, Y, additional, Matsuda, M, additional, Koike, A, additional, Koizumi, T, additional, Shimizu, M, additional, Ono, Y, additional, Takenaka, T, additional, Kotani, K, additional, Abe, M, additional, Akao, M, additional, and Hasegawa, K, additional

Published
2022
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23. Serum amyloid A-low-density-lipoprotein complex and mortality in patients with suspected or known coronary artery disease: the ANOX study

Author

Suzuki, M, primary, Kotani, K, additional, Matsuda, M, additional, Ajiro, Y, additional, Shinozaki, T, additional, Sakagami, S, additional, Yonezawa, K, additional, Shimizu, M, additional, Funada, J, additional, Takenaka, T, additional, Wada, M, additional, Abe, M, additional, Akao, M, additional, Hasegawa, K, additional, and Wada, H, additional

Published
2022
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24. Involvement of growth differentiation factor 15 in paradoxical relationship between body mass index and mortality in patients with suspected or known coronary artery disease; The ANOX Study

Author

Matsuda, M, primary, Suzuki, M, additional, Ajiro, Y, additional, Shinozaki, T, additional, Sakagami, S, additional, Yonezawa, K, additional, Shimizu, M, additional, Funada, J, additional, Takenaka, T, additional, Morita, Y, additional, Iguchi, M, additional, Abe, M, additional, Akao, M, additional, Hasegawa, K, additional, and Wada, H, additional

Published
2022
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25. Associations of soluble fms-like tyrosine kinase-1 with cardiovascular events and stroke in patients with atrial fibrillation and suspected or known coronary artery disease: the EXCEED-J study

Author

Wada, H, primary, Shinozaki, T, additional, Suzuki, M, additional, Sakagami, S, additional, Ajiro, Y, additional, Funada, J, additional, Matsuda, M, additional, Shimizu, M, additional, Takenaka, T, additional, Morita, Y, additional, Wada, K, additional, Kotani, K, additional, Abe, M, additional, Akao, M, additional, and Hasegawa, K, additional

Published
2022
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27. Majorana modes with side features in magnet-superconductor hybrid systems

Author

Crawford, D, Mascot, E, Shimizu, M, Beck, P, Wiebe, J, Wiesendanger, R, Jeschke, HO, Morr, DK, Rachel, S, Crawford, D, Mascot, E, Shimizu, M, Beck, P, Wiebe, J, Wiesendanger, R, Jeschke, HO, Morr, DK, and Rachel, S

Abstract

Magnet-superconductor hybrid (MSH) systems represent promising platforms to host Majorana zero modes (MZMs), the elemental building blocks for fault-tolerant quantum computers. Theoretical description of such MSH structures is mostly based on simplified models, not accounting for the complexity of real materials. Here, based on density functional theory, we derive a superconducting 80-band model to study an MSH system consisting of a magnetic manganese chain on the s wave superconductor niobium. For a wide range of values of the superconducting order parameter, the system is a topological superconductor, with MZMs exhibiting non-universal spatial patterns and a drastic accumulation of spectral weight on both sides along the magnetic chain. These side feature states can be explained by an effective model which is guided by the ab initio results. Performing scanning tunneling spectroscopy experiments on the same system, we observe a spatial structure in the low-energy local density of states that is consistent with the theoretical findings. Our results open a first-principle approach to the discovery of topological superconductors.

Published
2022

29. Prognostic value of machine learning for acute heart failure

Author

Shimizu, M, primary, Miyazaki, H, additional, Cho, S, additional, Misu, Y, additional, Tateishi, R, additional, Yamaguchi, M, additional, Yamakami, Y, additional, Shimada, H, additional, Manno, T, additional, Isshiki, A, additional, Kimura, S, additional, Fujii, H, additional, Suzuki, M, additional, Nishizaki, M, additional, and Sasano, T, additional

Published
2022
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31. Analysis of the circRNA and T-UCR populations identifies convergent pathways in mouse and human models of Rett syndrome

Author

Siqueira, E, Obiols-Guardia, A., Jorge-Torres, O.C., Oliveira-Mateos, Cristina, Soler, M., Ramesh-Kumar, Deepthi, Setién, F., van Rossum, D., Pascual-Alonso, A., Xiol, C., Ivan, C., Shimizu, M., Armstrong, Judith, Calin, George A, Pasterkamp, R. Jeroen, Esteller, M., Guil, Sonia, and Universitat Autònoma de Barcelona

Subjects
T-UCR, RM1-950, Expressió gènica, noncoding RNA, microtubules, Neurologia, Rett syndrome, Neurology, SIRT2, Drug Discovery, Molecular Medicine, Original Article, circRNA, Gene expression, Therapeutics. Pharmacology, AMPA receptor, GRIA3, MeCP2
Abstract

Noncoding RNAs play regulatory roles in physiopathology, but their involvement in neurodevelopmental diseases is poorly understood. Rett syndrome is a severe, progressive neurodevelopmental disorder linked to loss-of-function mutations of the MeCP2 gene for which no cure is yet available. Analysis of the noncoding RNA profile corresponding to the brain-abundant circular RNA (circRNA) and transcribed-ultraconserved region (T-UCR) populations in a mouse model of the disease reveals widespread dysregulation and enrichment in glutamatergic excitatory signaling and microtubule cytoskeleton pathways of the corresponding host genes. Proteomic analysis of hippocampal samples from affected individuals confirms abnormal levels of several cytoskeleton-related proteins together with key alterations in neurotransmission. Importantly, the glutamate receptor GRIA3 gene displays altered biogenesis in affected individuals and in vitro human cells and is influenced by expression of two ultraconserved RNAs. We also describe post-transcriptional regulation of SIRT2 by circRNAs, which modulates acetylation and total protein levels of GluR-1. As a consequence, both regulatory mechanisms converge on the biogenesis of AMPA receptors, with an effect on neuronal differentiation. In both cases, the noncoding RNAs antagonize MeCP2-directed regulation. Our findings indicate that noncoding transcripts may contribute to key alterations in Rett syndrome and are not only useful tools for revealing dysregulated processes but also molecules of biomarker value., Graphical abstract, circRNAs and T-UCRs identify convergent pathways in mouse and human models of Rett syndrome. GRIA3 biogenesis is altered in affected individuals and human cells influenced by two ultraconserved RNAs. SIRT2 is post-transcriptionally regulated by circRNAs. Noncoding RNAs antagonize MeCP2-directed regulation, highlighting the potential of noncoding RNAs (ncRNAs) as biomarkers in Rett syndrome.

Published
2022

32. Lysinibacillus xylanilyticus Strain GIC41 as a Potential Plant Biostimulant

Author

Ahsan, N., Marian, M., Suga, H., and Shimizu, M.

Subjects
Ribosomal, plant growth promotion, 16S, plant biostimulant, spinach, Lysinibacillus, Plant biostimulant, food and beverages, Spinach, Plant growth promotion, Phylogeny, RNA, Ribosomal, 16S, Rhizosphere, Seedlings, Spinacia oleracea, Bacillaceae, Soil Microbiology, Regular Paper, RNA
Abstract

To identify Lysinibacillus strains with the potential to function as plant biostimulants, we screened 10 previously isolated Lysinibacillus strains from the rhizosphere and soil for their plant growth-promoting (PGP) effects. In vitro tests showed that all strains produced indole-3-acetic acid. In primary screening, the PGP effects of these strains were assessed on spinach seedlings grown on Jiffy-7 pellets; strains GIC31, GIC41, and GIC51 markedly promoted shoot growth. In secondary screening, the PGP efficacies of these three strains were examined using spinach seedlings grown in pots under controlled conditions. Only GIC41 exerted consistent and significant PGP effects; therefore, it was selected for subsequent experiments. The results of 6-week glasshouse experiments revealed that GIC41 markedly increased shoot dry weight by ca. 12–49% over that of the control. The impact of fertilization levels on the PGP efficacy of GIC41 was investigated using pot experiments. The application of a specific level of fertilizer was required for the induction of sufficient PGP effects by this strain. The phylogenetic ana­lysis based on the 16S rDNA sequence identified GIC41 as L. xylanilyticus. Collectively, these results show the potential of strain GIC41 to function as a plant biostimulant.

Published
2021

33. Effect of dispersants of multi-walled carbon nanotubes on cellular uptake and biological responses

Author

Haniu H, Saito N, Matsuda Y, Kim YA, Park KC, Tsukahara T, Usui Y, Aoki K, Shimizu M, Ogihara N, Hara K, Takanashi S, Okamoto M, Ishigaki N, Nakamura K, and Kato H

Subjects
Medicine (General), R5-920
Abstract

Hisao Haniu1, Naoto Saito2, Yoshikazu Matsuda3, Yoong-Ahm Kim4, Ki Chul Park1, Tamotsu Tsukahara5, Yuki Usui6, Kaoru Aoki7, Masayuki Shimizu7, Nobuhide Ogihara7, Kazuo Hara7, Seiji Takanashi7, Masanori Okamoto7, Norio Ishigaki7, Koichi Nakamura7, Hiroyuki Kato71Institute of Carbon Science and Technology, Shinshu University, Matsumoto, Nagano, Japan; 2Department of Applied Physical Therapy, Shinshu University School of Health Sciences, Matsumoto, Nagano, Japan; 3Clinical Pharmacology Educational Center, Nihon Pharmaceutical University, Ina-machi, Saitama, Japan; 4Faculty of Engineering, Shinshu University, Nagano-shi, Nagano, Japan; 5Department of Integrative Physiology and Bio-System Control, Shinshu University School of Medicine, Matsumoto-shi, Nagano, Japan; 6Research Center for Exotic Nanocarbons, Shinshu University, Matsumoto, Nagano, Japan; 7Department of Orthopedic Surgery, Shinshu University School of Medicine, Matsumoto, Nagano, JapanAbstract: Although there have been many reports about the cytotoxicity of multi-walled carbon nanotubes (MWCNTs), the results are still controversial. To investigate one possible reason, the authors investigated the influence of MWCNT dispersants on cellular uptake and cytotoxicity. Cytotoxicity was examined (measured by alamarBlue® assay), as well as intracellular MWCNT concentration and cytokine secretion (measured by flow cytometry) in human bronchial epithelial cells (BEAS-2B) exposed to a type of highly purified MWCNT vapor grown carbon fiber (VGCF®, Showa Denko Kabushiki-gaisha, Tokyo, Japan) in three different dispersants (gelatin, carboxylmethyl cellulose, and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine). The authors also researched the relationship between the intracellular concentration of MWCNTs and cytotoxicity by using two cell lines, BEAS-2B and MESO-1 human malignant pleural mesothelioma cells. The intracellular concentration of VGCF was different for each of the three dispersants, and the levels of cytotoxicity and inflammatory response were correlated with the intracellular concentration of VGCF. A relationship between the intracellular concentration of VGCF and cytotoxic effects was observed in both cell lines. The results indicate that dispersants affect VGCF uptake into cells and that cytotoxicity depends on the intracellular concentration of VGCF, not on the exposed dosage. Thus, toxicity appears to depend on exposure time, even at low VGCF concentrations, because VGCF is biopersistent.Keywords: multi-walled carbon nanotube, cytotoxicity, intracellular concentration, dispersant, cytokine secretion

Published
2011

34. Elucidation mechanism of different biological responses to multi-walled carbon nanotubes using four cell lines

Author

Haniu H, Saito N, Matsuda Y, Kim YA, Park KC, Tsukahara T, Usui Y, Aoki K, Shimizu M, Ogihara N, Hara K, Takanashi S, Okamoto M, Ishigaki N, Nakamura K, and Kato H

Subjects
Medicine (General), R5-920
Abstract

Hisao Haniu1, Naoto Saito2, Yoshikazu Matsuda3, Yoong-Ahm Kim4, Ki Chul Park1, Tamotsu Tsukahara5, Yuki Usui6, Kaoru Aoki7, Masayuki Shimizu7, Nobuhide Ogihara7, Kazuo Hara7, Seiji Takanashi7, Masanori Okamoto7, Norio Ishigaki7, Koichi Nakamura7, Hiroyuki Kato71Institute of Carbon Science and Technology, Shinshu University, Matsumoto, Nagano, Japan; 2Department of Applied Physical Therapy, Shinshu University School of Health Sciences, Matsumoto, Nagano, Japan; 3Clinical Pharmacology Educational Center, Nihon Pharmaceutical University, Ina-machi, Saitama, Japan; 4Faculty of Engineering, Shinshu University, Nagano-shi, Nagano, Japan; 5Department of Integrative Physiology and Bio-System Control, Shinshu University School of Medicine, Matsumoto-shi, Nagano, Japan; 6Research Center for Exotic Nanocarbons, Shinshu University, Matsumoto, Nagano, Japan; 7Department of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto, Nagano, JapanAbstract: We examined differences in cellular responses to multi-walled carbon nanotubes (MWCNTs) using malignant pleural mesothelioma cells (MESO-1), bronchial epithelial cells (BEAS-2B), neuroblastoma cells (IMR-32), and monoblastic cells (THP-1), before and after differentiation. MESO-1, BEAS-2B and differentiated THP-1 cells actively endocytosed MWCNTs, resulting in cytotoxicity with lysosomal injury. However, cytotoxicity did not occur in IMR-32 or undifferentiated THP-1 cells. Both differentiated and undifferentiated THP-1 cells exhibited an inflammatory response. Carbon blacks were endocytosed by the same cell types without lysosomal damage and caused cytokine secretion, but they did not cause cytotoxicity. These results indicate that the cytotoxicity of MWCNTs requires not only cellular uptake but also lysosomal injury. Furthermore, it seems that membrane permeability or cytokine secretion without cytotoxicity results from several active mechanisms. Clarification of the cellular recognition mechanism for MWCNTs is important for developing safer MWCNTs.Keywords: multi-walled carbon nanotubes, cytotoxicity, endocytosis, cytokine secretion, reactive oxygen species

Published
2011

35. DJ-1 as a potential biomarker for the development of biocompatible multiwalled carbon nanotubes

Author

Haniu H, Tsukahara T, Matsuda Y, Usui Y, Aoki K, Shimizu M, Ogihara N, Hara K, Takanashi S, Okamoto M, Ishigaki N, Nakamura K, Kato H, and Saito N

Subjects
Medicine (General), R5-920
Abstract

Hisao Haniu1, Tamotsu Tsukahara2, Yoshikazu Matsuda3, Yuki Usui4, Kaoru Aoki5, Masayuki Shimizu5, Nobuhide Ogihara5, Kazuo Hara5, Seiji Takanashi5, Masanori Okamoto5, Norio Ishigaki5, Koichi Nakamura5, Hiroyuki Kato5, Naoto Saito6 1Institute of Carbon Science and Technology, 2Department of Integrative Physiology and Bio-System Control, Shinshu University, Matsumoto, Nagano, 3Clinical Pharmacology Educational Center, Nihon Pharmaceutical University, Ina-machi, Saitama, 4Research Center for Exotic Nanocarbons, 5Department of Orthopaedic Surgery, 6Department of Applied Physical Therapy, Shinshu University School of Health Sciences, Shinshu University, Matsumoto, Nagano, Japan Background: In the present study, we investigated whether DJ-1 could serve as a biomarker for assessing the biocompatibility of multiwalled carbon nanotubes (MWCNTs), using the highly purified carbon nanotube, HTT2800. Methods: Using Western blot analysis, we determined DJ-1 protein levels in two different types of cells (one capable and the other incapable of HTT2800 endocytosis). Using quantitative real-time polymerase chain reaction, we also investigated the ability of purified nanotubes to alter DJ-1 mRNA levels. Results: We demonstrated that the DJ-1 protein concentration was reduced, regardless of the cytotoxic activity of intracellular HTT2800. Furthermore, HTT2800 decreased the DJ-1 mRNA levels in a dose-dependent manner. This decrease in DJ-1 mRNA levels was not observed in the case of Sumi black or cup-stacked carbon nanotubes. Conclusion: These data indicate that modification of DJ-1 expression is caused by the cell response to MWCNTs. We conclude that DJ-1 is a promising candidate biomarker for the development of biocompatible MWCNTs. Keywords: multiwalled carbon nanotubes, DJ-1 protein, Western blot, quantitative real-time polymerase chain reaction

Published
2011

38. Rivaroxaban Monotherapy in Patients With Atrial Fibrillation After Coronary Stenting

Author

Matoba, Tetsuya, primary, Yasuda, Satoshi, additional, Kaikita, Koichi, additional, Akao, Masaharu, additional, Ako, Junya, additional, Nakamura, Masato, additional, Miyauchi, Katsumi, additional, Hagiwara, Nobuhisa, additional, Kimura, Kazuo, additional, Hirayama, Atsushi, additional, Matsui, Kunihiko, additional, Ogawa, Hisao, additional, Matoba, Tetsuya, additional, Koretsune, Yukihiro, additional, Hiro, Takafumi, additional, Sumiyoshi, Tetsuya, additional, Kimura, Kazumi, additional, Hashimoto, Yoichiro, additional, Hirano, Teruyuki, additional, Daida, Hiroyuki, additional, Okada, Yasushi, additional, Yamazaki, Tsutomu, additional, Nakamura, A., additional, Tamiya, E., additional, Yamamoto, T., additional, Suetake, S., additional, Noguchi, T., additional, Nakamura, S., additional, Matsumura, A., additional, Kojima, J., additional, Suwa, S., additional, Yamaguchi, H., additional, Kaikita, K., additional, Yasu, T., additional, Nakajima, A., additional, Yamada, T., additional, Arai, H., additional, Hata, Y., additional, Sakanashi, T., additional, Tateishi, H., additional, Nakayama, T., additional, Nozaki, Y., additional, Akao, M., additional, Okumura, Y., additional, Tokue, M., additional, Kuroki, N., additional, Maruyama, Y., additional, Matoba, T., additional, Hagiwara, N., additional, Suzuki, H., additional, Nishida, Y., additional, Ajioka, M., additional, Yumoto, K., additional, Shimizu, S., additional, Aoyama, T., additional, Shimomura, H., additional, Takeda, T., additional, Oshiro, K., additional, Sugishita, N., additional, Shibata, Y., additional, Otonari, T., additional, Kihara, H., additional, Ogawa, H., additional, Ohno, A., additional, Hazama, M., additional, Shimizu, M., additional, Tsukahara, K., additional, Haruta, S., additional, Wakeyama, T., additional, Haruna, T., additional, Ito, M., additional, Fujii, K., additional, Atsuchi, N., additional, Sata, M., additional, Kimura, K., additional, Hasebe, N., additional, Kobayasi, Y., additional, Ohsato, K., additional, Hironaga, K., additional, Naganuma, Y., additional, Anzaki, K., additional, Oiwa, K., additional, Okazaki, S., additional, Nakagawa, Y., additional, Tokuhiro, K., additional, Tanaka, K., additional, Momose, T., additional, Fukushima, Y., additional, Kametani, R., additional, Kawamitsu, K., additional, Saito, Y., additional, Akashi, S., additional, Kumagai, K., additional, Eshima, K., additional, Tobaru, T., additional, Seo, T., additional, Okuhara, K., additional, Kozuma, K., additional, Ikari, Y., additional, Takahashi, T., additional, Michishita, I., additional, Fujikura, H., additional, Momomura, S., additional, Yamamoto, Y., additional, Otomo, K., additional, Matsubara, T., additional, Tashiro, H., additional, Inoue, T., additional, Ishihara, M., additional, Shiojima, I., additional, Tachibana, E., additional, Ako, J., additional, Sumii, K., additional, Yamamoto, N., additional, Ohmura, N., additional, Nakamura, T., additional, Morita, Y., additional, Takahashi, N., additional, Watanabe, K., additional, Fujinaga, H., additional, Maruyama, M., additional, Oka, T., additional, Shirayama, T., additional, Amano, T., additional, Fukui, K., additional, Ando, K., additional, Oshima, S., additional, Kagiyama, S., additional, Teragawa, H., additional, Yuge, M., additional, Ono, S., additional, Koga, T., additional, Fujiu, K., additional, Kuwabara, M., additional, Ohya, Y., additional, Yumoto, Y., additional, Kuji, N., additional, Ikemura, M., additional, Kario, K., additional, Chatani, K., additional, Sato, K., additional, Miyagi, H., additional, Murakami, M., additional, Saito, K., additional, Hoshiga, M., additional, Sato, S., additional, Kubo, N., additional, Sakamoto, Y., additional, Ashida, K., additional, Sakamoto, H., additional, Murasaki, S., additional, Uehara, H., additional, Akasaka, T., additional, Ooba, Y., additional, Nakahara, S., additional, Hanaoka, Y., additional, Nishimiya, T., additional, Tsunoda, R., additional, Onuma, Y., additional, Higuchi, S., additional, Tani, A., additional, Wada, A., additional, Kato, M., additional, Obata, H., additional, Higuchi, Y., additional, Endo, T., additional, Katou, R., additional, Matsunaga, T., additional, Matsuoka, T., additional, Noguchi, H., additional, Usui, M., additional, Hayashi, T., additional, Otsuji, Y., additional, Osaki, T., additional, Zaizen, H., additional, Yoshihara, H., additional, Kadota, K., additional, Hirose, T., additional, Miyazawa, T., additional, Mori, A., additional, Takano, M., additional, Shimizu, W., additional, Wake, M., additional, Oriso, S., additional, Yoshiyama, M., additional, Kakinoki, S., additional, Nishioka, T., additional, Ozaki, T., additional, Nomoto, K., additional, Seki, K., additional, Kawai, K., additional, Ozaki, Y., additional, Miura, S., additional, Kawasaki, M., additional, Funada, R., additional, Dote, K., additional, Nagano, T., additional, Okamoto, S., additional, Kubo, T., additional, Murozono, Y., additional, Owada, T., additional, Doke, T., additional, Matsumura, T., additional, Horiuchi, M., additional, Takaishi, A., additional, Yamamoto, M., additional, Nakashima, H., additional, Munemasa, M., additional, Sakata, Y., additional, Inoue, N., additional, Ota, T., additional, Hamano, Y., additional, Abe, N., additional, Tsubokura, T., additional, Goto, M., additional, Kubota, I., additional, Yano, M., additional, Umetani, K., additional, Date, T., additional, Morimoto, H., additional, Noda, T., additional, Goto, S., additional, Hibi, K., additional, Nakano, A., additional, Hiramitsu, S., additional, Kihara, Y., additional, Sugi, M., additional, Shiba, N., additional, Izumi, D., additional, Sato, T., additional, Tayama, S., additional, Matsui, T., additional, Suzuki, A., additional, Ajiki, K., additional, Oishi, M., additional, Kiryu, M., additional, Ko, T., additional, Ando, H., additional, Miyazaki, S., additional, Kinugawa, T., additional, Otake, H., additional, Kitaoka, H., additional, Hirata, Y., additional, Honda, S., additional, Manita, M., additional, Ishii, Y., additional, Oka, H., additional, Nanba, Y., additional, Nishino, M., additional, Sakamoto, T., additional, Saito, T., additional, Sakai, H., additional, Ichikawa, M., additional, Namiuchi, S., additional, Inoue, K., additional, Komiyama, N., additional, Akashi, Y., additional, Nakamura, Y., additional, Komaru, T., additional, Hosokawa, T., additional, Chikamori, T., additional, Tanaka, H., additional, Arasaki, O., additional, Aonuma, K., additional, Wakasa, Y., additional, Yoshizawa, T., additional, Sugano, T., additional, Yokota, N., additional, Kakutani, A., additional, Suzuki, T., additional, Abe, Y., additional, Kataoka, T., additional, Okayama, H., additional, Yokoi, H., additional, Chin, K., additional, Hasegawa, K., additional, Tomita, H., additional, Honzyo, H., additional, Kawai, H., additional, Yamamoto, K., additional, Morino, Y., additional, Tsujiyama, S., additional, Hamasaki, S., additional, Niijima, Y., additional, Mizuno, Y., additional, Maki, A., additional, Tanabe, K., additional, Murohara, T., additional, Naomi, S., additional, Arikawa, M., additional, Kato, T., additional, Matsumoto, N., additional, Minamino, T., additional, Sairenji, H., additional, Miyamoto, N., additional, Ito, H., additional, Matsuura, Y., additional, Hata, S., additional, Nakatsu, Y., additional, Onodera, T., additional, Yoshimura, M., additional, Amano, H., additional, Tokutake, E., additional, Kasao, M., additional, Moriguchi, M., additional, Tsuji, M., additional, Yamamoto, H., additional, Yanbe, Y., additional, Iwasawa, T., additional, Suzuki, M., additional, and Mori, H., additional

Published
2021
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40. Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial

Author

Ray, K, Colhoun, H, Szarek, M, Baccara-Dinet, M, Bhatt, D, Bittner, V, Budaj, A, Diaz, R, Goodman, S, Hanotin, C, Harrington, R, Jukema, J, Loizeau, V, Lopes, R, Moryusef, A, Murin, J, Pordy, R, Ristic, A, Roe, M, Tunon, J, White, H, Zeiher, A, Schwartz, G, Steg, P, Tricoci, P, Mahaffey, K, Edelberg, J, Lecorps, G, Sasiela, W, Tamby, J, Aylward, P, Drexel, H, Sinnaeve, P, Dilic, M, Gotcheva, N, Prieto, J, Yong, H, Lopez-Jaramillo, P, Pecin, I, Reiner, Z, Ostadal, P, Viigimaa, M, Nieminen, M, Chumburidze, V, Marx, N, Danchin, N, Liberopoulos, E, Montenegro Valdovinos, P, Tse, H, Kiss, R, Xavier, D, Zahger, D, Valgimigli, M, Kimura, T, Kim, H, Kim, S, Erglis, A, Laucevicius, A, Kedev, S, Yusoff, K, Ramos Lopez, G, Alings, M, Halvorsen, S, Correa Flores, R, Morais, J, Dorobantu, M, Karpov, Y, Chua, T, Fras, Z, Dalby, A, de Silva, H, Hagstrom, E, Landmesser, U, Chiang, C, Sritara, P, Guneri, S, Parkhomenko, A, Moriarty, P, Vogel, R, Chaitman, B, Kelsey, S, Olsson, A, Rouleau, J, Simoons, M, Alexander, K, Meloni, C, Rosenson, R, Sijbrands, E, Alexander, J, Armaganijan, L, Bagai, A, Bahit, M, Brennan, J, Clifton, S, Devore, A, Deloatch, S, Dickey, S, Dombrowski, K, Ducrocq, G, Eapen, Z, Endsley, P, Eppinger, A, Harrison, R, Hess, C, Hlatky, M, Jordan, J, Knowles, J, Kolls, B, Kong, D, Leonardi, S, Lillis, L, Maron, D, Marcus, J, Mathews, R, Mehta, R, Mentz, R, Moreira, H, Patel, C, Bernardez-Pereira, S, Perkins, L, Povsic, T, Puymirat, E, Schuyler Jones, W, Shah, B, Sherwood, M, Stringfellow, K, Sujjavanich, D, Toma, M, Trotter, C, Van Diepen, S, Wilson, M, Yan, A, Schiavi, L, Garrido, M, Alvarisqueta, A, Sassone, S, Bordonava, A, Alves De Lima, A, Schmidberg, J, Duronto, E, Caruso, O, Novaretto, L, Hominal, M, Montana, O, Caccavo, A, Gomez Vilamajo, O, Lorenzatti, A, Cartasegna, L, Paterlini, G, Mackinnon, I, Caime, G, Amuchastegui, M, Salomone, O, Codutti, O, Jure, H, Bono, J, Hrabar, A, Vallejos, J, Ahuad Guerrero, R, Novoa, F, Patocchi, C, Zaidman, C, Giuliano, M, Dran, R, Vico, M, Carnero, G, Guzman, P, Medrano Allende, J, Garcia Brasca, D, Bustamante Labarta, M, Nani, S, Blumberg, E, Colombo, H, Liberman, A, Fuentealba, V, Luciardi, H, Waisman, G, Berli, M, Garcia Duran, R, Cestari, H, Luquez, H, Giordano, J, Saavedra, S, Zapata, G, Costamagna, O, Llois, S, Waites, J, Collins, N, Soward, A, Hii, C, Shaw, J, Arstall, M, Horowitz, J, Ninio, D, Rogers, J, Colquhoun, D, Oqueli Flores, R, Roberts-Thomson, P, Raffel, O, Lehman, S, Aroney, C, Coverdale, S, Garrahy, P, Starmer, G, Sader, M, Carroll, P, Dick, R, Zweiker, R, Hoppe, U, Huber, K, Berger, R, Delle-Karth, G, Frey, B, Weidinger, F, Faes, D, Hermans, K, Pirenne, B, Leone, A, Hoffer, E, Vrolix, M, De Wolf, L, Wollaert, B, Castadot, M, Dujardin, K, Beauloye, C, Vervoort, G, Striekwold, H, Convens, C, Roosen, J, Barbato, E, Claeys, M, Cools, F, Terzic, I, Barakovic, F, Midzic, Z, Pojskic, B, Fazlibegovic, E, Kulic, M, Durak-Nalbantic, A, Vulic, D, Muslibegovic, A, Goronja, B, Reis, G, Sousa, L, Nicolau, J, Giorgeto, F, Silva, R, Nigro Maia, L, Rech, R, Rossi, P, Cerqueira, M, Duda, N, Kalil, R, Kormann, A, Abrantes, J, Pimentel Filho, P, Soggia, A, de Santos, M, Neuenschwander, F, Bodanese, L, Michalaros, Y, Eliaschewitz, F, Vidotti, M, Leaes, P, Botelho, R, Kaiser, S, Manenti, E, Precoma, D, Moura Jorge, J, de B Silva, P, Silveira, J, Saporito, W, Marin-Neto, J, Feitosa, G, Ritt, L, de Souza, J, Costa, F, Souza, W, Reis, H, Machado, L, Ayoub, J, Todorov, G, Nikolov, F, Velcheva, E, Tzekova, M, Benov, H, Petranov, S, Tumbev, H, Shehova-Yankova, N, Markov, D, Raev, D, Mollov, M, Kichukov, K, Ilieva-Pandeva, K, Ivanova, R, Gospodinov, M, Mincheva, V, Lazov, P, Dimov, B, Senaratne, M, Stone, J, Kornder, J, Pearce, S, Dion, D, Savard, D, Pesant, Y, Pandey, A, Robinson, S, Gosselin, G, Vizel, S, Hoag, G, Bourgeois, R, Morisset, A, Sabbah, E, Sussex, B, Kouz, S, Macdonald, P, Diaz, A, Michaud, N, Fell, D, Leung, R, Vuurmans, T, Lai, C, Nigro, F, Davies, R, Nogareda, G, Vijayaraghavan, R, Ducas, J, Lepage, S, Mehta, S, Cha, J, Dupuis, R, Fong, P, Lutchmedial, S, Rodes-Cabau, J, Fadlallah, H, Cleveland, D, Huynh, T, Bata, I, Hameed, A, Pincetti, C, Potthoff, S, Acevedo, M, Aguirre, A, Vejar, M, Yanez, M, Araneda, G, Fernandez, M, Perez, L, Varleta, P, Florenzano, F, Huidobro, L, Raffo, C, Olivares, C, Nahuelpan, L, Montecinos, H, Chen, J, Dong, Y, Huang, W, Wang, J, Huang, S, Yao, Z, Li, X, Cui, L, Lin, W, Sun, Y, Li, J, Zhang, X, Zhu, H, Chen, D, Huang, L, Dong, S, Su, G, Xu, B, Su, X, Cheng, X, Lin, J, Zong, W, Li, H, Feng, Y, Xu, D, Yang, X, Ke, Y, Lin, X, Zhang, Z, Zheng, Z, Luo, Z, Chen, Y, Ding, C, Zhong, Y, Zheng, Y, Peng, D, Zhao, S, Li, Y, Liu, X, Wei, M, Liu, S, Yu, Y, Qu, B, Jiang, W, Zhou, Y, Zhao, X, Yuan, Z, Guo, Y, Xu, X, Shi, X, Ge, J, Fu, G, Bai, F, Fang, W, Shou, X, Xiang, M, Lu, Q, Zhang, R, Zhu, J, Xu, Y, Fan, Z, Li, T, Wu, C, Jaramillo, N, Sanchez Vallejo, G, Luna Botia, D, Botero Lopez, R, Molina De Salazar, D, Cadena Bonfanti, A, Cotes Aroca, C, Diego Higuera, J, Blanquicett, M, Barrera Silva, S, Garcia Lozada, H, Coronel Arroyo, J, Accini Mendoza, J, Fernandez Ruiz, R, Quintero Ossa, A, Manzur Jatin, F, Sotomayor Herazo, A, Castellanos Parada, J, Suarez Arambula, R, Urina Triana, M, Fernandez Trujillo, A, Strozzi, M, Car, S, Jeric, M, Milicic, D, Bencic, M, Pintaric, H, Prvulovic, D, Sikic, J, Persic, V, Mileta, D, Stambuk, K, Babic, Z, Tomulic, V, Lukenda, J, Mejic-Krstulovic, S, Starcevic, B, Spinar, J, Horak, D, Velicka, Z, Stasek, J, Alan, D, Machova, V, Linhart, A, Novotny, V, Kaucak, V, Rokyta, R, Naplava, R, Coufal, Z, Adamkova, V, Podpera, I, Zizka, J, Motovska, Z, Marusincova, I, Svab, P, Heinc, P, Kuchar, J, Povolny, P, Matuska, J, Poulsen, S, Raungaard, B, Clemmensen, P, Bang, L, May, O, Bottcher, M, Hove, J, Frost, L, Gislason, G, Larsen, J, Betton Johansen, P, Hald, F, Johansen, P, Jeppesen, J, Nielsen, T, Kristensen, K, Walichiewicz, P, Lomholdt, J, Klausen, I, Nielsen, P, Davidsen, F, Videbaek, L, Soots, M, Vahula, V, Hedman, A, Soopold, U, Martsin, K, Jurgenson, T, Kristjan, A, Helsinki, J, Vikman, S, Huikuri, H, Airaksinen, J, Coste, P, Ferrari, E, Morel, O, Montalescot, G, Machecourt, J, Barone-Rochette, G, Mansourati, J, Cottin, Y, Leclercq, F, Belhassane, A, Delarche, N, Boccara, F, Paganelli, F, Clerc, J, Schiele, F, Aboyans, V, Probst, V, Berland, J, Lefevre, T, Citron, B, Khintibidze, I, Shaburishvili, T, Pagava, Z, Ghlonti, R, Lominadze, Z, Khabeishvili, G, Hemetsberger, R, Edward, K, Rauch-Krohnert, U, Stratmann, M, Appel, K, Schmidt, E, Omran, H, Stellbrink, C, Dorsel, T, Lianopoulos, E, Vohringer, H, Marx, R, Zirlik, A, Schellenberg, D, Heitzer, T, Laufs, U, Werner, C, Gielen, S, Nuding, S, Winkelmann, B, Behrens, S, Sydow, K, Karakas, M, Simonis, G, Muenzel, T, Werner, N, Leggewie, S, Bocker, D, Braun-Dullaeus, R, Toursarkissian, N, Jeserich, M, Weissbrodt, M, Schaeufele, T, Weil, J, Voller, H, Waltenberger, J, Natour, M, Schmitt, S, Muller-Wieland, D, Steiner, S, Heidenreich, L, Offers, E, Gremmler, U, Killat, H, Rieker, W, Patsilinakos, S, Kartalis, A, Manolis, A, Sionis, D, Chachalis, G, Skoumas, I, Athyros, V, Vardas, P, Parthenakis, F, Alexopoulos, D, Hahalis, G, Lekakis, J, Hatzitolios, A, Fausto Ovando, S, Arango Benecke, J, Rodriguez De Leon, E, Yan, B, Siu, D, Turi, T, Merkely, B, Ungi, I, Lupkovics, G, Nagy, L, Katona, A, Edes, I, Muller, G, Horvath, I, Kapin, T, Szigeti, Z, Falukozy, J, Kumbla, M, Sandhu, M, Annam, S, Proddutur, N, Regella, R, Premchand, R, Mahajan, A, Pawar, S, Abhyanakar, A, Kerkar, P, Govinda, R, Oomman, A, Sinha, D, Patil, S, Kahali, D, Sawhney, J, Joshi, A, Chaudhary, S, Harkut, P, Guha, S, Porwal, S, Jujjuru, S, Pothineni, R, Monteiro, M, Khan, A, Iyengar, S, Grewal, J, Chopda, M, Fulwani, M, Patange, A, Sachin, P, Chopra, V, Goyal, N, Shinde, R, Manakshe, G, Patki, N, Sethi, S, Munusamy, V, Karna, S, Thanvi, S, Adhyapak, S, Patil, C, Pandurangi, U, Mathur, R, Gupta, J, Kalashetti, S, Bhagwat, A, Raghuraman, 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M., Schmalfuss C., Picone M., Pederson R., Herzog W., Friedman K., Lindsey J., Nowins R., Timothy E., Leonard P., Lepor N., El Shahawy M., Weintraub H., Irimpen A., Alonso A., May W., Christopher D., Galski T., Chu A., Mody F., Ramin E., Hodes Z., Rossi J., Rose G., Fairlamb J., Lambert C., Raisinghani A., Abbate A., Vetrovec G., King M., Carey C., Gerber J., Younis L., Park H. T., Vidovich M., Knutson T., Friedman D., Chaleff F., Loussararian A., Rozeman P., Kimmelstiel C., Kuvin J., Silver K., Foster M., Tonnessen G., Espinoza A., Amlani M., Wali A., Malozzi C., Jong G. T., Massey C., Wattanakit K., O'Donnell P. J., Singal D., Jaffrani N., Banuru S., Fisher D., Xenakis M., Perlmutter N., Bhagwat R., Strader J., Blonder R., Akyea-Djamson A., Labroo A., Marais H. J., Claxton E., Weiss R., Kathryn R., Berk M., Rossi P., Joshi P., Khera A., Khaira A. S., Kumkumian G., Lupovitch S., Purow J., Welka S., Hoffman D., Fischer S., Soroka E., Eagerton D., Pancholy S., Ray M., Erenrich N., Farrar M., Pollock S., French W. J., Diamantis S., Guy D., Gimple L., Neustel M., Schwartz S., Pereira E., Albert S., Spriggs D., Strain J., Mittal S., Vo A., Chane M., Hall J., Vijay N., Lotun K., Lester F. M., Nahhas A., Pope T., Nager P., Vohra R., Sharma M., Bashir R., Ahmed H., Berlowitz M., Fishberg R., Barrucco R., Yang E., Radin M., Sporn D., Stapleton D., Eisenberg S., Landzberg J., Mcgough M., Turk S., Schwartz M., Sundram P. S., Jain D., Zainea M., Bayron C., Karlsberg R., Dohad S., Lui H., Keen W., Westerhausen D., Khurana S., Agarwal H., Birchem J., Penny W., Chang M., Murphy S., Henry J., Schifferdecker B., Gilbert J. M., Chalavarya G., Eaton C., Schmedtje J. F., Christenson S., Dotani I., Denham D., Macdonell A., Gibson P., Rahman A., Al Joundi T., Assi N., Conrad G., Kotha P., Love M., Giesler G., Rubenstein H., Gamil D., Akright L., Krawczyk J., Cobler J., Wells T., Welker J., Foster R., Gilmore R., Anderson J., Jacoby D., Gardner G., Dandillaya R., Vora K., Kostis J., Hunter J., Laxson D., Ball E., Lopes R., Egydio F., Kawakami A., Oliveira J., Wozniak J., Matthews A., Ratky C., Valiris J., Berdan L., Hepditch A., Quintero K., Rorick T., Westbrook M., Pascual A., Rovito C., Bezault M., Drouet E., Simon T., Alsweiler C., Luyten A., Butters J., Griffith L., Shaw M., Grunberg L., Islam S., Bregeault M. -F., Bougon N., Faustino D., Fontecave S., Murphy J., Verrier M., Agnetti V., Andersen D., Badreddine E., Bekkouche M., Bouancheau C., Brigui I., Brocklehurst M., Cianciarulo J., Devaul D., Domokos S., Gache C., Gobillot C., Guillou S., Healy J., Heath M., Jaiwal G., Javierre C., Labeirie J., Monier M., Morales U., Mrabti A., Mthombeni B., Okan B., Smith L., Sheller J., Sopena S., Pellan V., Benbernou F., Bengrait N., Lamoureux M., Kralova K., Scemama M., Bejuit R., Coulange A., Berthou C., Repincay J., Lorenzato C., Etienne A., Gouet V., Normand M., Ourliac A., Rondel C., Adamo A., Beltran P., Barraud P., Dubois-Gache H., Halle B., Metwally L., Mourgues M., Sotty M., Vincendet M., Cotruta R., Chengyue Z., Fournie-Lloret D., Morrello C., Perthuis A., Picault P., Zobouyan I., Dempsey M. A., McClanahan M. 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R., Troquay R. P., Viergever E. P., Al-Windy N. Y., Bartels G. L., Cornel J. H., Hermans W. R., Herrman J. P., Bos R. J., Groutars R. G., Van Der Zwaan C. C., Kaplan R., Lionarons R., Ronner E., Groenemeijer B. E., Bronzwaer P. N., Liem A. A., Rensing B. J., Bokern M. J., Nijmeijer R., Hersbach F. M., Willems F. F., Gosselink A. T., Rasoul S., Elliott J., Wilkins G., Fisher R., Scott D., Hart H., Stewart R., Harding S., Ternouth I., Fisher N., Wilson S., Aitken D., Anscombe R., Davidson L., Tomala T., Nygard O., Sparby J. A., Andersen K., Gullestad L., Jortveit J., Munk P. S., Singsaas E. G., Hurtig U., Calderon Ticona J. R., Durand Velasquez J. R., Negron Miguel S. A., Sanabria Perez E. S., Carrion Chambilla J. M., Chavez Ayala C. A., Castillo Leon R. P., Vargas Gonzales R. J., Hernandez Zuniga J. D., Camacho Cosavalente L. A., Bravo Mannucci J. E., Heredia Landeo J., Llerena Navarro N. C., Roldan Concha Y. M., Rodriguez Chavez V. E., Anchante Hernandez H. A., Zea Nunez C. A., Mogrovejo Ramos W., Ferrolino A., Sy R. A. G., Tirador L., Sy R. G., Matiga G., Coching R. M., Bernan A., Rogelio G., Morales D. D., Tan E., Sulit D. J., Wlodarczak A., Jaworska K., Skonieczny G., Pawlowicz L., Wojewoda P., Busz-Papiez B., Bednarski J., Goch A., Staneta P., Dulak E., Saminski K., Krasowski W., Sudnik W., Zurakowski A., Skorski M., Miklaszewicz B., Kubica J., Andrzej Lipko J., Kostarska-Srokosz E., Piepiorka M., Drzewiecka A., Stasiewski A., Blicharski T., Bystryk L., Szpajer M., Korol M., Czerski T., Mirek-Bryniarska E., Gniot J., Lubinski A., Gorny J., Franek E., Raczak G., Szwed H., Monteiro P., Mesquita Bastos J., Pereira H. H., Martins D., Seixo F., Mendonca C., Botelho A., Caetano F., Minescu B., Istratoaie O., Tesloianu D. N., Cristian G., Dumitrescu S., Podoleanu C. G., Constantinescu M. C., Bengus C. M., Militaru C., Rosu D., Parepa I. R., Matei A. V., Alexandru T. M., Malis M., Coman I., Stanescu-Cioranu R., Dimulescu D., Shvarts Y., Orlikova O., Kobalava Z., Barbarash O. L., Markov V., Lyamina N., Gordienko A., Zrazhevsky K., Vishnevsky A. Y., Gurevich V., Stryuk R., Lomakin N. V., Bokarev I., Khlevchuk T., Shalaev S., Khaisheva L., Chizhov P., Viktorova I., Osokina N., Shchekotov V., Akatova E., Chumakova G., Libov I., Voevoda M. I., Tretyakova T. V., Baranov E., Shustov S., Yakushin S., Gordeev I., Khasanov N., Reshetko O., Sotnikova T., Molchanova O., Nikolaev K., Gapon L., Baranova E., Shogenov Z., Kosmachova E., Povzun A., Egorova L., Tyrenko V. V., Ivanov I. G., Ilya M., Kanorsky S., Simic D., Ivanovic N., Davidovic G., Tasic N., Asanin M. R., Stojic S., Apostolovic S. R., Ilic S., Putnikovic Tosic B., Stankovic A., Arandjelovic A., Radovanovic S., Todic B., Balinovac J., Dincic D. V., Seferovic P., Karadzic A., Dodic S., Dimkovic S., Jakimov T., Poh K. -K., Ong H. Y., Tang I-Shing J., Micko K., Nociar J., Pella D., Fulop P., Hranai M., Palka J., Mazur J., Majercak I., Dzupina A., Fazekas F., Gonsorcik J., Bugan V., Selecky J., Kamensky G., Strbova J., Smik R., Dukat A., Zuran I., Poklukar J., Cernic Suligoj N., Cevc M., Cyster H. P., Ranjith N., Corbett C., Bayat J., Makotoko E. M., du Toit Theron H., Kapp I. E., de V Basson M. M., Lottering H., Van Aswegen D., Van Zyl L. J., Sebastian P. J., Pillay T., Saaiman J. A., Commerford P. J., Cassimjee S., Riaz G., Ebrahim I. O., Sarvan M., Mynhardt J. H., Reuter H., Moodley R., Vida M., Cequier Fillat A. R., Bodi Peris V., Fuentes Jimenez F., Marin F., Cruz Fernandez J. M., Hidalgo Urbano R. J., Gil-Extremera B., Toledo P., Worner Diz F., Garcia-Dorado D., Iniguez A., Gonzalez-Juanatey J. R., Fernandez Portales J., Civeira Murillo F., Matas Pericas L., Zamorano J. L., De Mora Martin M., Bruguera Cortada J., Alonso Martin J. J., Serrano Antolin J. M., De Berrazueta Fernandez J. R., Vazquez de Prada J. A., Diaz Fernandez J. F., Garcia Lledo J. A., Cosin Sales J., Botas Rodriguez J., Gusi Tragant G., Benedicto A., Gonzalez-Juanatey C., Camprubi Potau M., Plaza Perez I., De La Tassa C. M., Loma-Osorio Rincon P., Balaguer Recena J., Escudier J. M., Payeras A. C., Alonso Orcajo N., Valdivielso P., Constantine G., Haniffa R., Tissera N., Amarasekera S., Ponnamperuma C., Fernando N., Fernando K., Jayawardena J., Wijeyasingam S., Ranasinghe G., Ekanayaka R., Mendis S., Senaratne V., Mayurathan G., Sirisena T., Rajapaksha A., Herath J. I., Amarasena N., Berglund S., Rasmanis G., Vedin O., Witt N., Mourtzinis G., Nicol P., Hansen O., Romeo S., Agergaard Jensen S., Torstensson I., Ahremark U., Sundelin T., Moccetti T., Muller C., Mach F., Binde R., Tsai W. -C., Ueng K. -C., Lai W. -T., Liu M. -E., Hwang J. -J., Yin W. -H., Hsieh I. -C., Hsieh M. -J., Lin W. H., Kuo J. -Y., Huang T. -Y., Fang C. -Y., Kaewsuwanna P., Soonfuang W., Jintapakorn W., Sukonthasarn A., Wongpraparut N., Sastravaha K., Sansanayudh N., Kehasukcharoen W., Piyayotai D., Chotnoparatpat P., Camsari A., Kultursay H., Mutlu B., Ersanli M., Demirtas M., Kirma C., Ural E., Koldas L., Karpenko O., Prokhorov A., Vakaluyk I., Myshanych H., Reshotko D., Batushkin V., Rudenko L., Kovalskyi I., Kushnir M., Tseluyko V., Mostovoy Y., Stanislavchuk M., Kyiak Y., Karpenko Y., Malynovsky Y., Klantsa A., Kutniy O., Amosova E., Tashchuk V., Leshchuk O., Rishko M., Kopytsya M., Yagensky A., Vatutin M., Bagriy A., Barna O. M., Ushakov O., Dzyak G., Goloborodko B., Rudenko A., Zheleznyy V., Trevelyan J., Zaman A., Lee K., Moriarty A., Aggarwal R. K., Clifford P., Wong Y. -K., Iqbal S. M., Subkovas E., Braganza D., Sarkar D., Storey R., Griffiths H., McClure S., Muthusamy R., Smith S., Kurian J., Levy T., Barr C., Kadr H., Gerber R., Simaitis A., Soran H., Mathur A., Brodison A., Ayaz M., Cheema M., Oliver R., Thackray S., Mudawi T., Rahman G., Sultan A., Sharman D., Sprigings D., Butler R., Wilkinson P., Lip G. Y., Halcox J., Gallagher S., Ossei-Gerning N., Vardi G., Baldari D., Brabham D., Treasure II C., Dahl C., Palmer B., Wiseman A., Puri S., Mohart A. E., Ince C., Flores E., Wright S., Cheng S. -C., Rosenberg M., Rogers W., Kosinski E., Forgosh L., Waltman J., Khan M., Shoukfeh M., Dagher G., Cambier P., Lieber I., Kumar P., East C., Krichmar P., Hasan M., White L., Knickelbine T., Haldis T., Gillespie E., Amidon T., Suh D., Arif I., Abdallah M., Akhter F., Carlson E., D'Urso M., El-Ahdab F., Nelson W., Moriarty K., Harris B., Cohen S., Carter L., Doty D., Sabatino K., Haddad T., Malik A., Rao S., Mulkay A., Jovin I., Klancke K., Malhotra V., Devarapalli S. K., Koren M., Chandna H., Dodds III G., Goraya T., Bengston J., Janik M., Moran J., Sumner A., Kobayashi J., Davis W., Yazdani S., Pasquini J., Thakkar M., Vedere A., Leimbach W., Rider J., Fenton S., Singh N., Shah A. V., Janosik D., Pepine C., Berman B., Gelormini J., Daniels C., Richard K., Keating F., Kondo N. I., Shetty S., Levite H., Waider W., Takata T., Abu-Fadel M., Shah V., Aggarwal R., Izzo M., Kumar A., Hattler B., Do R., Link C., Bortnick A., Kinzfogl III G., Ghitis A., Larry J., Teufel E., Kuhlman P., Mclaurin B., Zhang W., Thew S., Abbas J., White M., Islam O., Subherwal S., Ranadive N., Vakili B., Gring C., Henderson D., Schuchard T., Farhat N., Kline G., Mahal S., Whitaker J., Speirs S., Andersen R., Daboul N., Horwitz P., Zahr F., Ponce G., Jafar Z., Mcgarvey J., Panchal V., Voyce S., Blok T., Sheldon W., Azizad M. M., Schmalfuss C., Picone M., Pederson R., Herzog W., Friedman K., Lindsey J., Nowins R., Timothy E., Leonard P., Lepor N., El Shahawy M., Weintraub H., Irimpen A., Alonso A., May W., Christopher D., Galski T., Chu A., Mody F., Ramin E., Hodes Z., Rossi J., Rose G., Fairlamb J., Lambert C., Raisinghani A., Abbate A., Vetrovec G., King M., Carey C., Gerber J., Younis L., Park H. T., Vidovich M., Knutson T., Friedman D., Chaleff F., Loussararian A., Rozeman P., Kimmelstiel C., Kuvin J., Silver K., Foster M., Tonnessen G., Espinoza A., Amlani M., Wali A., Malozzi C., Jong G. T., Massey C., Wattanakit K., O'Donnell P. J., Singal D., Jaffrani N., Banuru S., Fisher D., Xenakis M., Perlmutter N., Bhagwat R., Strader J., Blonder R., Akyea-Djamson A., Labroo A., Marais H. J., Claxton E., Weiss R., Kathryn R., Berk M., Rossi P., Joshi P., Khera A., Khaira A. S., Kumkumian G., Lupovitch S., Purow J., Welka S., Hoffman D., Fischer S., Soroka E., Eagerton D., Pancholy S., Ray M., Erenrich N., Farrar M., Pollock S., French W. J., Diamantis S., Guy D., Gimple L., Neustel M., Schwartz S., Pereira E., Albert S., Spriggs D., Strain J., Mittal S., Vo A., Chane M., Hall J., Vijay N., Lotun K., Lester F. M., Nahhas A., Pope T., Nager P., Vohra R., Sharma M., Bashir R., Ahmed H., Berlowitz M., Fishberg R., Barrucco R., Yang E., Radin M., Sporn D., Stapleton D., Eisenberg S., Landzberg J., Mcgough M., Turk S., Schwartz M., Sundram P. S., Jain D., Zainea M., Bayron C., Karlsberg R., Dohad S., Lui H., Keen W., Westerhausen D., Khurana S., Agarwal H., Birchem J., Penny W., Chang M., Murphy S., Henry J., Schifferdecker B., Gilbert J. M., Chalavarya G., Eaton C., Schmedtje J. F., Christenson S., Dotani I., Denham D., Macdonell A., Gibson P., Rahman A., Al Joundi T., Assi N., Conrad G., Kotha P., Love M., Giesler G., Rubenstein H., Gamil D., Akright L., Krawczyk J., Cobler J., Wells T., Welker J., Foster R., Gilmore R., Anderson J., Jacoby D., Gardner G., Dandillaya R., Vora K., Kostis J., Hunter J., Laxson D., Ball E., Lopes R., Egydio F., Kawakami A., Oliveira J., Wozniak J., Matthews A., Ratky C., Valiris J., Berdan L., Hepditch A., Quintero K., Rorick T., Westbrook M., Pascual A., Rovito C., Bezault M., Drouet E., Simon T., Alsweiler C., Luyten A., Butters J., Griffith L., Shaw M., Grunberg L., Islam S., Bregeault M. -F., Bougon N., Faustino D., Fontecave S., Murphy J., Verrier M., Agnetti V., Andersen D., Badreddine E., Bekkouche M., Bouancheau C., Brigui I., Brocklehurst M., Cianciarulo J., Devaul D., Domokos S., Gache C., Gobillot C., Guillou S., Healy J., Heath M., Jaiwal G., Javierre C., Labeirie J., Monier M., Morales U., Mrabti A., Mthombeni B., Okan B., Smith L., Sheller J., Sopena S., Pellan V., Benbernou F., Bengrait N., Lamoureux M., Kralova K., Scemama M., Bejuit R., Coulange A., Berthou C., Repincay J., Lorenzato C., Etienne A., Gouet V., Normand M., Ourliac A., Rondel C., Adamo A., Beltran P., Barraud P., Dubois-Gache H., Halle B., Metwally L., Mourgues M., Sotty M., Vincendet M., Cotruta R., Chengyue Z., Fournie-Lloret D., Morrello C., Perthuis A., Picault P., Zobouyan I., Dempsey M. A., and McClanahan M. A.

Abstract

Background: After acute coronary syndrome, diabetes conveys an excess risk of ischaemic cardiovascular events. A reduction in mean LDL cholesterol to 1·4–1·8 mmol/L with ezetimibe or statins reduces cardiovascular events in patients with an acute coronary syndrome and diabetes. However, the efficacy and safety of further reduction in LDL cholesterol with an inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) after acute coronary syndrome is unknown. We aimed to explore this issue in a prespecified analysis of the ODYSSEY OUTCOMES trial of the PCSK9 inhibitor alirocumab, assessing its effects on cardiovascular outcomes by baseline glycaemic status, while also assessing its effects on glycaemic measures including risk of new-onset diabetes. Methods: ODYSSEY OUTCOMES was a randomised, double-blind, placebo-controlled trial, done at 1315 sites in 57 countries, that compared alirocumab with placebo in patients who had been admitted to hospital with an acute coronary syndrome (myocardial infarction or unstable angina) 1–12 months before randomisation and who had raised concentrations of atherogenic lipoproteins despite use of high-intensity statins. Patients were randomly assigned (1:1) to receive alirocumab or placebo every 2 weeks; randomisation was stratified by country and was done centrally with an interactive voice-response or web-response system. Alirocumab was titrated to target LDL cholesterol concentrations of 0·65–1·30 mmol/L. In this prespecified analysis, we investigated the effect of alirocumab on cardiovascular events by glycaemic status at baseline (diabetes, prediabetes, or normoglycaemia)—defined on the basis of patient history, review of medical records, or baseline HbA1c or fasting serum glucose—and risk of new-onset diabetes among those without diabetes at baseline. The primary endpoint was a composite of death from coronary heart disease, non-fatal myocardial infarction, fatal or non-fatal ischaemic stroke, or unstable angina requiring

Published
2019

43. Evaluation of Preoperative Diagnostic Methods for Resectable Pancreatic Cancer

Author

Yasuda I, Uemura S, Shimizu M, Iwashita T, Maruta A, and Yoshida K

Subjects
body regions, Resectable Pancreatic Cancer, medicine.medical_specialty, surgical procedures, operative, Diagnostic methods, Text mining, business.industry, Medicine, Radiology, skin and connective tissue diseases, business
Abstract

Background: In pancreatic cancer clinical practice guideline 2016, it is recommended to perform pathological diagnosis as much as possible, but priorities and algorithms for diagnostic methods have not yet been established. In recent years, EUS-FNA has become mainstream as a method of collecting tissues from pancreatic disease, but the effect of EUS-FNA on surgical results and prognosis has not been clarified.Aims: To evaluate the diagnostic ability of EUS-FNA and preoperative diagnosis affects surgical outcome and prognosis of pancreatic cancer.Methods: Between January 2005 and June 2017, 293 patients who had surgical resection for pancreatic cancer were retrospectively evaluated. The interested outcomes were diagnostic ability of EUS-FNA and the influence for surgical result and prognosis.Results: The diagnostic sensitivity of EUS-FNA was 94.4%, which was significantly higher than ERCP (45.5%) (pp=0.001). Patients were divided into FNA group (N=160) and non-FNA group (N=133) for each preoperative diagnostic method. In the study of surgical curability R0 between two groups, there was no significant difference in FNA group: 65.0% (104/160) and non-FNA group: 64.7% (86/133), (p=1.000). In the prognostic study, the total of 256 patients with curability R0 or R1, the recurrence rate was 54.3% (70/129) in the FNA group and 57.4% (73/127) in non-FNA group. Moreover peritoneal dissemination occurred 34.3% (24/70) in the FNA group and 21.9% (16/73) in the non-FNA group, neither of which showed significant difference. The median survival time of FNA group and non-FNA group were 955 days and 799 days, respectively, and there was no significant difference between the two groups (Log rank p=0.735). In the Cox proportional hazards model examining factors influencing prognosis, staging, curability and adjuvant chemotherapy were dominant factors, but preoperative diagnostic method(EUS-FNA) itself was not.Conclusions: As a preoperative examination of pancreatic cancer, EUS-FNA was shown to be a safe procedure with high diagnostic ability. It was considered to be the first choice without the influence of surgical curability, postoperative recurrence, peritoneal dissemination and prognosis.

Published
2021

44. Diagnostic performance of deep learning on 12-leads electrocardiography for recurrence after pulmonary vein isolation in patients with persistent atrial fibrillation

Author

Shimizu, M, primary, Miyazaki, H, additional, Cho, S, additional, Misu, Y, additional, Tateishi, R, additional, Yamaguchi, M, additional, Yamakami, Y, additional, Shimada, H, additional, Manno, T, additional, Isshiki, A, additional, Kimura, S, additional, Fujii, H, additional, Suzuki, M, additional, Nishizaki, M, additional, and Sasano, T, additional

Published
2021
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45. Intracellular localization of AMP deaminase and its novel role in BCAA and lipid metabolism in diabetic cardiomyopathy

Author

Ogawa, T, primary, Kouzu, H, additional, Osanami, A, additional, Tatekoshi, Y, additional, Oshima, H, additional, Mizuno, M, additional, Kuno, A, additional, Fujita, Y, additional, Ino, S, additional, Shimizu, M, additional, Ohwada, W, additional, Sato, T, additional, Yano, T, additional, Tanno, M, additional, and Miura, T, additional

Published
2021
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47. The transcriptional response to salicylic acid plays a role in Fusarium yellows resistance in Brassica rapa L.

Author

Miyaji, N, Shimizu, M, Takasaki-Yasuda, T, Dennis, ES, Fujimoto, R, Miyaji, N, Shimizu, M, Takasaki-Yasuda, T, Dennis, ES, and Fujimoto, R

Abstract

KEY MESSAGE: Fusarium yellows resistant and susceptible lines in Brassica rapa showed different salicylic acid responses; the resistant line showed a similar response to previous reports, but the susceptible line differed. Fusarium yellows caused by Fusarium oxysporum f. sp. conglutinans (Foc) is an important disease. Previous studies showed that genes related to salicylic acid (SA) response were more highly induced following Foc infection in Brassica rapa Fusarium yellows resistant lines than susceptible lines. However, SA-induced genes have not been identified at the whole genome level and it was unclear whether they were up-regulated by Foc inoculation. Transcriptome analysis with and without SA treatment in the B. rapa Fusarium yellows susceptible line 'Misugi' and the resistant line 'Nanane' was performed to obtain insights into the relationship between SA sensitivity/response and Fusarium yellows resistance. 'Nanane's up-regulated genes were related to SA response and down-regulated genes were related to jasmonic acid (JA) or ethylene (ET) response, but differentially expressed genes in 'Misugi' were not. This result suggests that Fusarium yellows resistant and susceptible lines have a different SA response and that an antagonistic transcription between SA and JA/ET responses was found only in a Fusarium yellows resistant line. SA-responsive genes were induced by Foc inoculation in Fusarium yellows resistant (RJKB-T23) and susceptible lines (RJKB-T24). By contrast, 39 SA-induced genes specific to RJKB-T23 might function in the defense response to Foc. In this study, SA-induced genes were identified at the whole genome level, and the possibility, the defense response to Foc observed in a resistant line could be mediated by SA-induced genes, is suggested. These results will be useful for future research concerning the SA importance in Foc or other diseases resistance in B. rapa.

Published
2021

48. Development of a New DNA Marker for Fusarium Yellows Resistance in Brassica rapa Vegetables

Author

Miyaji, N, Akter, MA, Suzukamo, C, Mehraj, H, Shindo, T, Itabashi, T, Okazaki, K, Shimizu, M, Kaji, M, Katsumata, M, Dennis, ES, Fujimoto, R, Miyaji, N, Akter, MA, Suzukamo, C, Mehraj, H, Shindo, T, Itabashi, T, Okazaki, K, Shimizu, M, Kaji, M, Katsumata, M, Dennis, ES, and Fujimoto, R

Abstract

In vegetables of Brassica rapa L., Fusarium oxysporum f. sp. rapae (For) or F. oxysporum f. sp. conglutinans (Foc) cause Fusarium yellows. A resistance gene against Foc (FocBr1) has been identified, and deletion of this gene results in susceptibility (focbr1-1). In contrast, a resistance gene against For has not been identified. Inoculation tests showed that lines resistant to Foc were also resistant to For, and lines susceptible to Foc were susceptible to For. However, prediction of disease resistance by a dominant DNA marker on FocBr1 (Bra012688m) was not associated with disease resistance of For in some komatsuna lines using an inoculation test. QTL-seq using four F2 populations derived from For susceptible and resistant lines showed one causative locus on chromosome A03, which covers FocBr1. Comparison of the amino acid sequence of FocBr1 between susceptible and resistant alleles (FocBr1 and FocBo1) showed that six amino acid differences were specific to susceptible lines. The presence and absence of FocBr1 is consistent with For resistance in F2 populations. These results indicate that FocBr1 is essential for For resistance, and changed amino acid sequences result in susceptibility to For. This susceptible allele is termed focbr1-2, and a new DNA marker (focbr1-2m) for detection of the focbr1-2 allele was developed

Published
2021

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