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3. Relative Safety and Efficacy of Two Doses of Tandospirone Citrate for Generalized Anxiety Disorder: A Multicenter Randomized Controlled Trial

Author

Li,Qingwei, Zhang,Haiyin, Lin,Guozhen, Shi,Shenxun, Zhang,Yingli, Ji,Jianlin, Yang,Lipeng, Yao,Jun, Wu,Wenyuan, Li,Qingwei, Zhang,Haiyin, Lin,Guozhen, Shi,Shenxun, Zhang,Yingli, Ji,Jianlin, Yang,Lipeng, Yao,Jun, and Wu,Wenyuan

Abstract

Qingwei Li,1 Haiyin Zhang,2 Guozhen Lin,3 Shenxun Shi,4 Yingli Zhang,5 Jianlin Ji,6 Lipeng Yang,7 Jun Yao,1 Wenyuan Wu1 1Department of Psychiatry, Tongji Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China; 2Clinical Psychology, Shanghai Mental Health Center, Shanghai, People’s Republic of China; 3Department of Psychiatry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 4Psychiatry Department, Fudan University Affiliated Huashan Hospital, Shanghai, People’s Republic of China; 5Department of Depressive Disorders, Shenzhen Kangning Hospital, Shenzhen Mental Health Center, Shenzhen, People’s Republic of China; 6Department of Psychological Medicine, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China; 7Department of Neurology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, People’s Republic of ChinaCorrespondence: Wenyuan Wu, Department of Psychiatry, Tongji Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China, Email wuwy@tongji.edu.cnPurpose: To determine the relative safety and efficacy of different doses of tandospirone in treating generalized anxiety disorder (GAD).Patients and Methods: This parallel randomized controlled trial enrolled patients with GAD from eight centers in China. The patients were randomly assigned to 60 mg/day or 30 mg/day tandospirone groups. The primary endpoint was the overall response rate after receiving 6-week treatment. The secondary endpoints included significant response rate, clinical recovery rate, change in the Hamilton Anxiety Scale (HAMA) total score, HAMA subscale score, Hamilton Depression Scale-17 (HAMD-17), Clinical Global Impression-Severity Scale (CGI-S) score, and Impression-Improvement scale (CGI-I) score.Results: No significant difference was found in the overall response rate between the two groups (65.7% vs 58.4%

Published
2022

4. Sparse whole-genome sequencing identifies two loci for major depressive disorder

Author

Cai, Na, Bigdeli, Tim B., Kretzschmar, Warren, Li, Yihan, Liang, Jieqin, Song, Li, Hu, Jingchu, Li, Qibin, Jin, Wei, Hu, Zhenfei, Wang, Guangbiao, Wang, Linmao, Qian, Puyi, Liu, Yuan, Jiang, Tao, Lu, Yao, Zhang, Xiuqing, Yin, Ye, Li, Yingrui, Xu, Xun, Gao, Jingfang, Reimers, Mark, Webb, Todd, Riley, Brien, Bacanu, Silviu, Peterson, Roseann E., Chen, Yiping, Zhong, Hui, Liu, Zhengrong, Wang, Gang, Sun, Jing, Sang, Hong, Jiang, Guoqing, Zhou, Xiaoyan, Li, Yi, Zhang, Wei, Wang, Xueyi, Fang, Xiang, Pan, Runde, Miao, Guodong, Zhang, Qiwen, Hu, Jian, Yu, Fengyu, Du, Bo, Sang, Wenhua, Li, Keqing, Chen, Guibing, Cai, Min, Yang, Lijun, Yang, Donglin, Ha, Baowei, Hong, Xiaohong, Deng, Hong, Li, Gongying, Li, Kan, Song, Yan, Gao, Shugui, Zhang, Jinbei, Gan, Zhaoyu, Meng, Huaqing, Pan, Jiyang, Gao, Chengge, Zhang, Kerang, Sun, Ning, Li, Youhui, Niu, Qihui, Zhang, Yutang, Liu, Tieqiao, Hu, Chunmei, Zhang, Zhen, Lv, Luxian, Dong, Jicheng, Wang, Xiaoping, Tao, Ming, Wang, Xumei, Xia, Jing, Rong, Han, He, Qiang, Liu, Tiebang, Huang, Guoping, Mei, Qiyi, Shen, Zhenming, Liu, Ying, Shen, Jianhua, Tian, Tian, Liu, Xiaojuan, Wu, Wenyuan, Gu, Danhua, Fu, Guangyi, Shi, Jianguo, Chen, Yunchun, Gan, Xiangchao, Liu, Lanfen, Wang, Lina, Yang, Fuzhong, Cong, Enzhao, Marchini, Jonathan, Yang, Huanming, Wang, Jian, Shi, Shenxun, Mott, Richard, Xu, Qi, Wang, Jun, Kendler, Kenneth S., and Flint, Jonathan

Published
2015
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5. Early symptom non-improvement and aggravation are associated with the treatment response to SSRIs in MDD: a real-world study

Author

Yuan, Hsinsung, Zhu, Xiao, Luo, Qiang, Halim, Alice, Halim, Michael, Yao, Hao, Cai, Yiyun, and Shi, Shenxun

Subjects
Neuropsychiatric Disease and Treatment, major depressive disorder, selective serotonin reuptake inhibitors, antidepressants, early improvement, Original Research
Abstract

Hsinsung Yuan,1,2Xiao Zhu,1 Qiang Luo,3,4 Alice Halim,5 Michael Halim,5 Hao Yao,5 Yiyun Cai,1,6 Shenxun Shi1,6 1Psychiatry Department of Huashan Hospital, Fudan University, Shanghai, People’s Republic of China; 2Psychiatry Department of Nanjing Brain Hospital, Nanjing, People’s Republic of China; 3Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, People’s Republic of China; 4Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Ministry of Education), Fudan University, Shanghai, People’s Republic of China; 5Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China; 6Shanghai Mental Health Center, Shanghai, People’s Republic of China Purpose: Early improvement in major depressive disorder is defined as a reduction of ≥20% in the 17-item Hamilton Depression Rating Scale (HAM-D-17) score at the second week after initiation of treatment, predicting long-term treatment response. However, there remains no effective strategy for switching medications when a patient fails to reach early improvement at the second week. This study focused on the predictive value of early symptom changes in each item of the HAM-D-17 scale for treatment response to selective serotonin reuptake inhibitor (SSRI) monotherapy and to provide a reference for switching antidepressants to enhance early treatment efficacy. Patients and methods: Our study was an observational, real-world study that enrolled 90 treatment-naïve patients experiencing their first episode of major depressive disorder in the outpatient department of Huashan Hospital. Patients who did not achieve the threshold of early improvement in the second week after starting treatment were switched to alternative SSRI monotherapy. Patient follow-up occurred at 2, 4, 8, and 12weeks after the initiation of treatment. We analyzed the relationship between the change in each symptom on the HAM-D-17 scale and treatment efficacy. Results: Early improvement predicted the treatment response at 12weeks (χ2=19.249, P999.999); treatment-emergent headache and tremor were associated with treatment efficacy (t=-9.521,P

Published
2019

7. Early symptom non-improvement and aggravation are associated with the treatment response to SSRIs in MDD: a real-world study

Author

Yuan,Hsinsung, Zhu,Xiao, Luo,Qiang, Halim,Alice, Halim,Michael, Yao,Hao, Cai,Yiyun, Shi,Shenxun, Yuan,Hsinsung, Zhu,Xiao, Luo,Qiang, Halim,Alice, Halim,Michael, Yao,Hao, Cai,Yiyun, and Shi,Shenxun

Abstract

Hsinsung Yuan,1,2 Xiao Zhu,1 Qiang Luo,3,4 Alice Halim,5 Michael Halim,5 Hao Yao,5 Yiyun Cai,1,6 Shenxun Shi1,6 1Psychiatry Department of Huashan Hospital, Fudan University, Shanghai, People’s Republic of China; 2Psychiatry Department of Nanjing Brain Hospital, Nanjing, People’s Republic of China; 3Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, People’s Republic of China; 4Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Ministry of Education), Fudan University, Shanghai, People’s Republic of China; 5Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China; 6Shanghai Mental Health Center, Shanghai, People’s Republic of China Purpose: Early improvement in major depressive disorder is defined as a reduction of ≥20% in the 17-item Hamilton Depression Rating Scale (HAM-D-17) score at the second week after initiation of treatment, predicting long-term treatment response. However, there remains no effective strategy for switching medications when a patient fails to reach early improvement at the second week. This study focused on the predictive value of early symptom changes in each item of the HAM-D-17 scale for treatment response to selective serotonin reuptake inhibitor (SSRI) monotherapy and to provide a reference for switching antidepressants to enhance early treatment efficacy. Patients and methods: Our study was an observational, real-world study that enrolled 90 treatment-naïve patients experiencing their first episode of major depressive disorder in the outpatient department of Huashan Hospital. Patients who did not achieve the threshold of early improvement in the second week after starting treatment were switched to alternative SSRI monotherapy. Patient follow-up occurred at 2, 4, 8, and 12 weeks after the initiation of treatment. We analyzed the relationship between

Published
2019

8. Factors Associated with Significant Anxiety and Depressive Symptoms in Pregnant Women with a History of Complications

Author

CHEN, Jing, CAI, Yiyun, LIU, Yue, QIAN, Jieyan, LING, Qing, ZHANG, Wei, LUO, Jianfeng, CHEN, Yan, and SHI, Shenxun

Subjects
depression, high-risk pregnancy, Original Research Article, anxiety
Abstract

The occurrence of complications during the gestation period is higher among pregnant women with a history of complications than among pregnant women without previous complications. High-risk pregnancy can cause negative emotional symptoms such as anxiety and depression in pregnant women. Current research on anxiety and depression symptoms in pregnant women is sparse.To examine the incidence of anxiety and depression symptoms in pregnant women with a history of previous complications or high risk pregnancy and related risk factors.Women with a history of previous complications in pregnancy or current 'high risk' pregnancy (e.g. test tube fertilization, etc.) were classified as 'high risk'. 197 of these 'high risk' women who were in their second trimester (16 to 20 weeks) underwent a monthly comprehensive assessment using the Hospital Anxiety and Depression Scale (HAD) in the last 4 months of the gestation period. The Edinburgh Postnatal Depression Scale (EPDS) was used for assessment and risk factor investigation 3 to 7 days, 42 days, and 3 months after childbirth.The mean (sd) HAD anxiety score among 'high-risk'women at the time of enrollment was 3.69 (2.76) and depression score was 3.42 (2.53). Significant anxiety symptoms and depression symptoms were found in 14 cases (7.18 %) and 10 cases (5.13%), respectively. Multivariate analysis showed a correlation between anxiety symptoms and history of miscarriage (OR: 8.162, 95%CI: 1.213 to 54.914)and testing positive for hepatitis (OR: 8.912, 95%CI: 1.052 to 75.498). Depressive symptoms were correlated with glucose positive urine (OR: 30.529, 95%CI: 1.312 to 710.610) and history of hemorrhaging (OR: 7.122, 95%CI: 1.015 to 49.984). General factors associated with anxiety and depression symptoms include patients' health status in the recent 3 months, concerns about fetal health, quality of marital relationship, and relationship with in-laws.Anxiety and depression symptoms are commonly seen in pregnant women with a history of previous complications or current 'high risk' pregnancy. Patients' recent health status, relationship with in-laws, marital quality and concerns about fetal health are associated with anxiety and depression symptoms during pregnancy.高危孕妇与普通孕妇相比在妊娠期会出现更多的并发症，高危因素作为一种应激因素更易诱发孕妇产生焦虑、抑郁等负面情绪症状。目前国内外对高危孕妇焦虑、抑郁症状的研究相对较少。.调查产科高危妊娠孕妇焦虑、抑郁症状发生率及其相关危险因素。.对197 例孕中期（16-20 周）的高危孕妇在妊娠最后4 月每月进行综合性医院焦虑/ 抑郁量表（HAD）评估和风险因素调查。产后3-7 天、42 天及3 月进行爱丁堡产后抑郁量表（EPDS）评估和风险因素调查。.入组时高危孕妇HAD 焦虑均分：3.69(2.76)，抑郁均分：3.42 (2.53)。焦虑症状14 例(7.18%)，抑郁症状10 例(5.13%)。多因素分析显示，怀孕有无保胎（OR：8.162, 95%CI：1.213-54.914）和乙肝阳性（OR：8.912, 95%CI：1.052-75.498）与焦虑症状相关。尿糖阳性（OR： 30.529, 95%CI：1.312-710.610）和既往出血史（OR：7.122, 95%CI：1.015-49.984）与抑郁症状相关。孕期影响高危孕妇焦虑、抑郁症状的因素有：近3 月孕妇健康状况、担心胎儿健康、夫妻关系、婆媳关系等。.高危妊娠孕妇焦虑、抑郁症状较常见。近3 月孕妇健康状况、婆媳关系、夫妻关系、担心胎儿健康是高危孕妇孕期焦虑、抑郁症状的风险因素。.

Published
2016

15. Obsessive compulsive symptoms in bipolar disorder patients: a comorbid disorder or a subtype of bipolar disorder?

Author

SHI, Shenxun

Subjects
bipolar disorder, Forum, obsessive compulsive disorder, mental disorders, comorbid mental disorders
Abstract

Summary Over the last decade increasing attention has been focused on individuals that simultaneously meet the criteria of two or more mental disorders. One of these comorbid conditions, comorbid bipolar disorder and obsessive compulsive disorder, is relatively common among patients with a primary diagnosis of bipolar disorder. But there is little research about the diagnosis and treatment of this comorbid condition, particularly in China. The available studies are primarily cross-sectional studies with small samples, so they are of limited use in understanding the etiology and course of this combined condition. A review of the limited literature suggests that this is a relatively severe, refractory subtype of bipolar disorder that only occasionally merits being considered a comorbid disorder. Larger prospective studies are needed to clarify the etiology, prognosis, and appropriate treatment for this comorbid condition.

Published
2015

16. [Evaluation of 99mTc-ECD SPECT/CT brain imaging with scenium analysis in patients with generalized anxiety disorder]

Author

Liu, Zhuang, Shi, Shenxun, Liu, Xingdang, Zhao, Menglong, Liu, Congjin, Wang, Yuankai, and Liu, Miao

Subjects
Tomography, Emission-Computed, Single-Photon, Brain, Humans, Cysteine, Organotechnetium Compounds, Tomography, X-Ray Computed, Anxiety Disorders
Abstract

To assess the perfusion changes in brains of patients with varying levels of generalized anxiety disorder (GAD).A total of 38 GAD outpatients of Department of Psychiatry at our hospital from February to August, 2014 and 10 healthy controls received a 99mTC-ECD SPECT/CT scan with scenium analysis. Differences between brain perfusion and anxiety levels were analyzed by SPSS 16. 0 with one-way ANOVA, Pearson's Chi-square, t test and Spearman's correlation.They were grouped according to the levels of anxiety severity, i. e. mild (n = 11) , moderate (n = 16) and severe (n = 11). They had significantly lower blood flow in right superior frontal medial gyrus, right precuneus, right putamen, bilateral paracentral lobule and bilateral supplementary motor area (t = -2.19, -2.14, -2.22, -2.34, -2.08, -3.26, -2.72, P0.05). Individuals had significantly greater blood flow in mild group than those of control group in right olfactory (t = 2.09 P = 0.05). Individuals of moderate group had significantly lower blood flow than those of control group in left superior frontal gyrus medial orbital, right superior frontal gyrus medial orbital and left supplementary motor area, but greater in right olfactory (t = -2.16, -2.24, -2.49, 2.17, P = 0.04, 0.04, 0.02, 0.04). Individuals had lower blood flow in severe group than those of control group in left frontal lobe, right putamen, left paracentral lobule, right paracentral lobule, left precuneus, right precuneus, left parietal lobe, left precentral, right precentral, right postcentral, left rolandic operculum, left supplementary motor area, right supplementary motor area and left central region (t = -2.32, -2.11, -3.16, -2.61, -2.39, -2.18, -2.32, -2.67, -2.14, -2.11, -2.25, -4.38, -3.54, -2.38, P = 0.03, 0.05, 0.01, 0.02, 0.03, 0.04, 0.03, 0.02, 0.05, 0.05, 0.04, 0.00, 0.00, 0.03). Statistical differences existed in right middle frontal gyms orbital part (mild: 0.96 ± 0.07, moderate: 1.03 ± 0.06, severe: 0.98 ± 0.08, P = 0.04) and left paracentral (mild: 0.91 ± 0.07, moderate: 093 ± 004 severe: 0.87 ± 0.07, P = 0.02). There was a tendency of negative correlation between perfusion in right middle cingulate and paracingulate gyri, left precuneus, right precuneus and left thalamus and anxiety scores by Spearman's correlation analysis (r = -0.28, -0.28, -0.27, -0.29, P = 0.09, 0.09, 0.10, 0.07).Scenium software provides quantitative measurements for diagnosis of GAD in different anxiety levels. Also larger samples are required for confirming the results in further studies.

Published
2015

17. CONVERGE dataset: 12,000 whole-genome sequences representative of the Han Chinese population

Author

Cai, Na, primary, Bigdeli, Tim, additional, Kretzschmar, Warren, additional, Li, Yihan, additional, Liang, Jieqin, additional, Song, Li, additional, Hu, Jingchu, additional, Li, Qibin, additional, Jin, Wei, additional, Hu, Zhenfei, additional, Wang, Guangbiao, additional, Wang, Linmao, additional, Qian, Puyi, additional, Liu, Yuan, additional, Jiang, Tao, additional, Lu, Yao, additional, Zhang, Xiuqing, additional, Yin, Ye, additional, Li, Yingrui, additional, Xu, Xun, additional, Gan, Xiangchao, additional, Reimers, Mark, additional, Webb, Todd, additional, Riley, Brien, additional, Bacanu, Silviu, additional, Peterson, Roseann E, additional, Chen, Yiping, additional, Zhong, Hui, additional, Liu, Zhengrong, additional, Wang, Gang, additional, Sun, Jing, additional, Sang, Hong, additional, Jiang, Guoqing, additional, Zhou, Xiaoyan, additional, Li, Yi, additional, Zhang, Wei, additional, Wang, Xueyi, additional, Fang, Xiang, additional, Pan, Runde, additional, Miao, Guodong, additional, Zhang, Qiwen, additional, Hu, Jian, additional, Yu, Fengyu, additional, Du, Bo, additional, Sang, Wenhua, additional, Li, Keqing, additional, Chen, Guibing, additional, Cai, Min, additional, Yang, Lijun, additional, Yang, Donglin, additional, Ha, Baowei, additional, Hong, Xiaohong, additional, Deng, Hong, additional, Li, Gongying, additional, Li, Kan, additional, Song, Yan, additional, Gao, Shugui, additional, Zhang, Jinbei, additional, Gan, Zhaoyu, additional, Meng, Huaqing, additional, Pan, Jiyang, additional, Gao, Chengge, additional, Zhang, Kerang, additional, Sun, Ning, additional, Li, Youhui, additional, Niu, Qihui, additional, Zhang, Yutang, additional, Liu, Tieqiao, additional, Hu, Chunmei, additional, Zhang, Zhen, additional, Lv, Luxian, additional, Dong, Jicheng, additional, Wang, Xiaoping, additional, Tao, Ming, additional, Wang, Xumei, additional, Xia, Jing, additional, Rong, Han, additional, He, Qiang, additional, Liu, Tiebang, additional, Huang, Guoping, additional, Mei, Qiyi, additional, Shen, Zhenming, additional, Liu, Ying, additional, Shen, Jianhua, additional, Tian, Tian, additional, Liu, Xiaojuan, additional, Wu, Wenyuan, additional, Gu, Danhua, additional, Fu, Guangyi, additional, Shi, Jianguo, additional, Chen, Yunchun, additional, Gao, Jingfang, additional, Liu, Lanfen, additional, Wang, Lina, additional, Yang, Fuzhong, additional, Cong, Enzhao, additional, Marchini, Jonathan, additional, Yang, Huanming, additional, Wang, Jian, additional, Shi, Shenxun, additional, Mott, Richard, additional, Wang, Jun, additional, Kendler, Kenneth S, additional, and Flint, Jonathan, additional

Published
2016
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18. A review of SPECT studies in psychiatry in China

Author

Shi, Shenxun and Shu, Liang

Subjects
schizophrenia, obsessive compulsive disorder, SPECT, mental disorders, depression, Reviews, anxiety disorder, vascular dementia, Alzheimer’s disease
Abstract

Background Studies of mental disorders using single photon emission computed tomography (SPECT) have been done for many years in China. Many results have been obtained. We review these findings and introduce them to the outside world. Methods SPECT papers available on the Chinese Biomedical Bibliographic Database, focusing on depression, schizophrenia, Alzheimer’s disease (AD), vascular dementia (VD), anxiety disorder, and obsessive compulsive disorder (OCD) in China, were reviewed and the results were compared with those obtained outside China. Results We found that regional cerebral blood flow (rCBF) was abnormal in mental disorders, but the specificity of the abnormality is not yet consistent. Lower perfusion of rCBF could be seen in frontal, temporal, and parietal lobes of patients with depression, AD, schizophrenia, and VD. It seems that abnormality of the frontal lobe is more common in depression and schizophrenia, but temporal lobe abnormalities are more common in AD and VD. The perfusion of rCBF in the parietal lobe seems to be related to aging. Abnormalities in the occipital lobe and basal ganglia seem to be more associated with vascular problems. Thalamic dysfunction was mainly correlated with VD, and that of the cingulate largely with depression and schizophrenia. Hippocampal abnormalities were associated with AD. There were few reports on changes in anxiety disorders and other mental problems. Conclusion There is no specific biological marker of SPECT for individual mental disorders. Further study is needed to provide more specific information on the pathophysiology of mental disorders. It seems that brain abnormalities are similar in Chinese and non Chinese psychiatric patients.

Published
2006

19. Relationship between apathy and tumor location, size, and brain edema in patients with intracranial meningioma

Author

Peng,Yihua, Shao,Chunhong, Gong,Ye, Wu,Xuehai, Tang,Weijun, Shi,Shenxun, Peng,Yihua, Shao,Chunhong, Gong,Ye, Wu,Xuehai, Tang,Weijun, and Shi,Shenxun

Abstract

Yihua Peng,1,* Chunhong Shao,1,* Ye Gong,2 Xuehai Wu,2 Weijun Tang,3 Shenxun Shi1 1Psychiatry Department, 2Neurosurgery Department, 3Radiology Department, Huashan Hospital, Fudan University, People’s Republic of China *These authors contributed equally to this work Background: The purpose of this study is to assess the relationship between apathy and tumor location, size, and brain edema in patients with intracranial meningioma. Methods: We enrolled 65 consecutive patients with meningioma and 31 normal controls matched for age, gender, and education. The patients were divided into frontal or non-frontal (NF) meningioma groups based on magnetic resonance imaging; the frontal group was then subdivided to dorsolateral frontal (DLF), medial frontal (MF), and ventral frontal (VF) groups. Tumor size and brain edema were also recorded. Apathy was assessed by the Apathy Evaluation Scale (AES). Assessments were carried out 1 week before and 3 months after surgery, respectively. Logistic regression analysis was performed to identify the predictive effect of tumor size, location, and brain edema on apathy. Analysis of variance and chi-square analysis were applied to compare apathy scores and apathy rates among the frontal, NF, and normal control groups, and all subgroups within the frontal group. Results: Compared with the NF and control groups, the mean AES score was much higher in the frontal group (34.0±8.3 versus 28.63±6.0, P=0.008, and 26.8±4.2, P<0.001). Subgroup analysis showed that AES scores in the MF group (42.1±6.6) and VF group (34.7±8.0) were higher than in the DLF group (28.5±4.36), NF group, and control group (P<0.05). The apathy rate was 63.6% in the MF group and 25% in the VF group, and significantly higher than in the DLF (5.6%), NF (5.3%), and control (0%) groups (P<0.001). A moderate correlation was found between AES score and mean diameter of the menin

Published
2015

22. Smoking and Major Depressive Disorder in Chinese Women

Author

He, Qiang, primary, Yang, Lei, additional, Shi, Shenxun, additional, Gao, Jingfang, additional, Tao, Ming, additional, Zhang, Kerang, additional, Gao, Chengge, additional, Yang, Lijun, additional, Li, Kan, additional, Shi, Jianguo, additional, Wang, Gang, additional, Liu, Lanfen, additional, Zhang, Jinbei, additional, Du, Bo, additional, Jiang, Guoqing, additional, Shen, Jianhua, additional, Zhang, Zhen, additional, Liang, Wei, additional, Sun, Jing, additional, Hu, Jian, additional, Liu, Tiebang, additional, Wang, Xueyi, additional, Miao, Guodong, additional, Meng, Huaqing, additional, Li, Yi, additional, Hu, Chunmei, additional, Huang, Guoping, additional, Li, Gongying, additional, Ha, Baowei, additional, Deng, Hong, additional, Mei, Qiyi, additional, Zhong, Hui, additional, Gao, Shugui, additional, Sang, Hong, additional, Zhang, Yutang, additional, Fang, Xiang, additional, Yu, Fengyu, additional, Yang, Donglin, additional, Liu, Tieqiao, additional, Chen, Yunchun, additional, Hong, Xiaohong, additional, Wu, Wenyuan, additional, Chen, Guibing, additional, Cai, Min, additional, Song, Yan, additional, Pan, Jiyang, additional, Dong, Jicheng, additional, Pan, Runde, additional, Zhang, Wei, additional, Shen, Zhenming, additional, Liu, Zhengrong, additional, Gu, Danhua, additional, Wang, Xiaoping, additional, Liu, Ying, additional, Liu, Xiaojuan, additional, Zhang, Qiwen, additional, Li, Yihan, additional, Chen, Yiping, additional, Kendler, Kenneth S., additional, Wang, Xumei, additional, Li, Youhui, additional, and Flint, Jonathan, additional

Published
2014
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23. Associations of Educational Attainment, Occupation, Social Class and Major Depressive Disorder among Han Chinese Women

Author

Shi, Jianguo, primary, Zhang, Yan, additional, Liu, Feihu, additional, Li, Yajuan, additional, Wang, Junhui, additional, Flint, Jonathan, additional, Gao, Jingfang, additional, Li, Youhui, additional, Tao, Ming, additional, Zhang, Kerang, additional, Wang, Xumei, additional, Gao, Chengge, additional, Yang, Lijun, additional, Li, Kan, additional, Shi, Shenxun, additional, Wang, Gang, additional, Liu, Lanfen, additional, Zhang, Jinbei, additional, Du, Bo, additional, Jiang, Guoqing, additional, Shen, Jianhua, additional, Zhang, Zhen, additional, Liang, Wei, additional, Sun, Jing, additional, Hu, Jian, additional, Liu, Tiebang, additional, Wang, Xueyi, additional, Miao, Guodong, additional, Meng, Huaqing, additional, Li, Yi, additional, Hu, Chunmei, additional, Huang, Guoping, additional, Li, Gongying, additional, Ha, Baowei, additional, Deng, Hong, additional, Mei, Qiyi, additional, Zhong, Hui, additional, Gao, Shugui, additional, Sang, Hong, additional, Zhang, Yutang, additional, Fang, Xiang, additional, Yu, Fengyu, additional, Yang, Donglin, additional, Liu, Tieqiao, additional, Chen, Yunchun, additional, Hong, Xiaohong, additional, Wu, Wenyuan, additional, Chen, Guibing, additional, Cai, Min, additional, Song, Yan, additional, Pan, Jiyang, additional, Dong, Jicheng, additional, Pan, Runde, additional, Zhang, Wei, additional, Shen, Zhenming, additional, Liu, Zhengrong, additional, Gu, Danhua, additional, Wang, Xiaoping, additional, Liu, Xiaojuan, additional, Zhang, Qiwen, additional, Li, Yihan, additional, Chen, Yiping, additional, and Kendler, Kenneth S., additional

Published
2014
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24. Childhood Sexual Abuse and the Development of Recurrent Major Depression in Chinese Women

Author

Chen, Jing, primary, Cai, Yiyun, additional, Cong, Enzhao, additional, Liu, Ying, additional, Gao, Jingfang, additional, Li, Youhui, additional, Tao, Ming, additional, Zhang, Kerang, additional, Wang, Xumei, additional, Gao, Chengge, additional, Yang, Lijun, additional, Li, Kan, additional, Shi, Jianguo, additional, Wang, Gang, additional, Liu, Lanfen, additional, Zhang, Jinbei, additional, Du, Bo, additional, Jiang, Guoqing, additional, Shen, Jianhua, additional, Zhang, Zhen, additional, Liang, Wei, additional, Sun, Jing, additional, Hu, Jian, additional, Liu, Tiebang, additional, Wang, Xueyi, additional, Miao, Guodong, additional, Meng, Huaqing, additional, Li, Yi, additional, Hu, Chunmei, additional, Huang, Guoping, additional, Li, Gongying, additional, Ha, Baowei, additional, Deng, Hong, additional, Mei, Qiyi, additional, Zhong, Hui, additional, Gao, Shugui, additional, Sang, Hong, additional, Zhang, Yutang, additional, Fang, Xiang, additional, Yu, Fengyu, additional, Yang, Donglin, additional, Liu, Tieqiao, additional, Chen, Yunchun, additional, Hong, Xiaohong, additional, Wu, Wenyuan, additional, Chen, Guibing, additional, Cai, Min, additional, Song, Yan, additional, Pan, Jiyang, additional, Dong, Jicheng, additional, Pan, Runde, additional, Zhang, Wei, additional, Shen, Zhenming, additional, Liu, Zhengrong, additional, Gu, Danhua, additional, Wang, Xiaoping, additional, Liu, Xiaojuan, additional, Zhang, Qiwen, additional, Li, Yihan, additional, Chen, Yiping, additional, Kendler, Kenneth S., additional, Shi, Shenxun, additional, and Flint, Jonathan, additional

Published
2014
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25. Differential attentional bias in generalized anxiety disorder and panic disorder

Author

Chen,Jing, Wang, Wu, Yiyun Cai, Shen, Shi,Shenxun, Chen,Jing, Wang, Wu, Yiyun Cai, Shen, and Shi,Shenxun

Abstract

Jing Chen, Zhiyan Wang, Yan Wu, Yiyun Cai, Yifeng Shen, Liwei Wang, Shenxun ShiDepartment of Psychiatry, Huashan Hospital, Fudan University, Shanghai, People's Republic of ChinaBackground: Cognitive theorists relate anxiety disorders to the way in which emotional information is processed. The existing research suggests that patients with anxiety disorders tend to allocate their attention toward threat-related information selectively, and this may differ among different types of anxious subjects. The aim of this study was to explore attentional bias in patients with generalized anxiety disorder (GAD) and panic disorder (PD) using the emotional Stroop task and compare the differences between them.Methods: Forty-two patients with GAD, 34 patients with PD, and 46 healthy controls performed the emotional Stroop task with four word types, ie, GAD-related words, PD-related words, neutral words, and positive words.Results: Patients with GAD and those with PD were slower than healthy controls to respond to all stimuli. Patients with GAD had longer response latencies in color-naming both PD-relevant words and GAD relevant words. Patients with PD had longer response latencies only in color-naming PD-related words, similar to healthy controls.Conclusion: Patients with GAD and those with PD had a different pattern of attentional bias, and there was insufficient evidence to support the existence of specific attentional bias in patients with PD.Keywords: generalized anxiety disorder, panic disorder, attentional bias, emotional Stroop task

Published
2013

26. Clinical Features of Patients with Dysthymia in a Large Cohort of Han Chinese Women with Recurrent Major Depression

Author

Wu, Wenqing, primary, Wang, Zhoubing, additional, Wei, Yan, additional, Zhang, Guanghua, additional, Shi, Shenxun, additional, Gao, Jingfang, additional, Li, Youhui, additional, Tao, Ming, additional, Zhang, Kerang, additional, Wang, Xumei, additional, Gao, Chengge, additional, Yang, Lijun, additional, Li, Kan, additional, Shi, Jianguo, additional, Wang, Gang, additional, Liu, Lanfen, additional, Zhang, Jinbei, additional, Du, Bo, additional, Jiang, Guoqing, additional, Shen, Jianhua, additional, Liu, Ying, additional, Liang, Wei, additional, Sun, Jing, additional, Hu, Jian, additional, Liu, Tiebang, additional, Wang, Xueyi, additional, Miao, Guodong, additional, Meng, Huaqing, additional, Li, Yi, additional, Hu, Chunmei, additional, Huang, Guoping, additional, Li, Gongying, additional, Ha, Baowei, additional, Deng, Hong, additional, Mei, Qiyi, additional, Zhong, Hui, additional, Gao, Shugui, additional, Sang, Hong, additional, Zhang, Yutang, additional, Fang, Xiang, additional, Yu, Fengyu, additional, Yang, Donglin, additional, Liu, Tieqiao, additional, Chen, Yunchun, additional, Hong, Xiaohong, additional, Wu, Wenyuan, additional, Chen, Guibing, additional, Cai, Min, additional, Song, Yan, additional, Pan, Jiyang, additional, Dong, Jicheng, additional, Pan, Runde, additional, Zhang, Wei, additional, Shen, Zhenming, additional, Liu, Zhengrong, additional, Gu, Danhua, additional, Wang, Xiaoping, additional, Liu, Xiaojuan, additional, Zhang, Qiwen, additional, Li, Yihan, additional, Chen, Yiping, additional, Kendler, Kenneth S., additional, Flint, Jonathan, additional, and Zhang, Zhen, additional

Published
2013
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27. Suicidal Risk Factors of Recurrent Major Depression in Han Chinese Women

Author

Zhu, Yuzhang, primary, Zhang, Hongni, additional, Shi, Shenxun, additional, Gao, Jingfang, additional, Li, Youhui, additional, Tao, Ming, additional, Zhang, Kerang, additional, Wang, Xumei, additional, Gao, Chengge, additional, Yang, Lijun, additional, Li, Kan, additional, Shi, Jianguo, additional, Wang, Gang, additional, Liu, Lanfen, additional, Zhang, Jinbei, additional, Du, Bo, additional, Jiang, Guoqing, additional, Shen, Jianhua, additional, Zhang, Zhen, additional, Liang, Wei, additional, Sun, Jing, additional, Hu, Jian, additional, Liu, Tiebang, additional, Wang, Xueyi, additional, Miao, Guodong, additional, Meng, Huaqing, additional, Li, Yi, additional, Hu, Chunmei, additional, Huang, Guoping, additional, Li, Gongying, additional, Ha, Baowei, additional, Deng, Hong, additional, Mei, Qiyi, additional, Zhong, Hui, additional, Gao, Shugui, additional, Sang, Hong, additional, Zhang, Yutang, additional, Fang, Xiang, additional, Yu, Fengyu, additional, Yang, Donglin, additional, Liu, Tieqiao, additional, Chen, Yunchun, additional, Hong, Xiaohong, additional, Wu, Wenyuan, additional, Chen, Guibing, additional, Cai, Min, additional, Song, Yan, additional, Pan, Jiyang, additional, Dong, Jicheng, additional, Pan, Runde, additional, Zhang, Wei, additional, Shen, Zhenming, additional, Liu, Zhengrong, additional, Gu, Danhua, additional, Wang, Xiaoping, additional, Liu, Xiaojuan, additional, Zhang, Qiwen, additional, Li, Yihan, additional, Chen, Yiping, additional, Kendler, Kenneth Seedman, additional, Flint, Jonathan, additional, and Liu, Ying, additional

Published
2013
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28. A review of neuroimaging studies of anxiety disorders in China

Author

Chen,Jing, Shi,Shenxun, Chen,Jing, and Shi,Shenxun

Abstract

Jing Chen, Shenxun ShiDepartment of Psychiatry, Huashan Hospital, Fudan University, Shanghai, ChinaBackground: Anxiety disorders are highly prevalent internationally, and constitute a substantial social and economic burden for patients, their families, and society. A number of neuroimaging studies have investigated the etiology of anxiety disorders in China in the last decade. We discuss the findings of these studies, and compare them with the results of neuroimaging studies of anxiety disorders outside China.Method: A literature search was conducted using the Chinese BioMedical Literature Database, the Chinese Scientific and Technical Periodicals Database, the Chinese Journal Full-text Database, and PubMed, from 1989 to April 2009. We selected neuroimaging studies in which all participants and researchers were Chinese.Results: Twenty-five studies fit our inclusion criteria. Nine studies examined general anxiety disorder (GAD) and/or panic disorder (PD), eight examined obsessive-compulsive disorder (OCD), and eight examined posttraumatic stress disorder (PTSD). Our literature review revealed several general findings. First, reduced regional cerebral blood flow (rCBF) was found in the frontal lobe and temporal lobe in patients with GAD and PD compared with healthy controls. Second, when viewing images with negative and positive valence, relatively increased or decreased activation was found in several brain areas in patients with GAD and PD, respectively. Third, studies with positron emission tomography (PET) and magnetic resonance spectroscopy (MRS) imaging revealed that OCD patients exhibited hyperperfusion and hypoperfusion in some brain regions compared with healthy controls. Neuroimaging studies of PTSD indicate that the hippocampal volume and the N-acetylaspartic acid (NAA) level and the NAA/creatine ratio in the hippocampus are decreased in patients relative to controls.Conclusion: Neuroimaging studies within and outside China have provided evidence of specifi

Published
2011

29. Resemblance of Symptoms for Major Depression Assessed at Interview versus from Hospital Record Review

Author

Chen, Ying, primary, Li, Haimin, additional, Li, Yihan, additional, Xie, Dong, additional, Wang, Zhiyang, additional, Yang, Fuzhong, additional, Shen, Yuan, additional, Ni, Sulin, additional, Wei, Yan, additional, Liu, Yanhua, additional, Liu, Lanfen, additional, Gao, Chengge, additional, Liu, Jun, additional, Yan, Lijuan, additional, Wang, Gang, additional, Li, Keqing, additional, He, Qiang, additional, Liu, Tiebang, additional, Zhang, Jinbei, additional, Ren, Yan, additional, Du, Qunli, additional, Tian, Jing, additional, Chen, Honghui, additional, Luo, Yanfang, additional, Zhang, Fengzhi, additional, Sun, Guangwei, additional, Shan, Chunjie, additional, Wang, Xueyi, additional, Zhang, Yutang, additional, Weng, Xiaoqin, additional, Chen, Yunchun, additional, Kang, Zhen, additional, Guan, Jing, additional, Chen, Yiping, additional, Shi, Shenxun, additional, Kendler, Kenneth S., additional, Flint, Jonathan, additional, and Deng, Hong, additional

Published
2012
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30. The therapeutic effect of quetiapine on cognitive impairment associated with 5-HT1A presynaptic receptor involved schizophrenia.

Author

Han D, Shi S, and Luo H

Subjects
Animals, Cyclic AMP-Dependent Protein Kinases metabolism, Hippocampus drug effects, Hippocampus metabolism, Male, Neurons drug effects, Neurons metabolism, Rats, Rats, Sprague-Dawley, Receptors, Presynaptic drug effects, Antipsychotic Agents pharmacology, Cognitive Dysfunction etiology, Cognitive Dysfunction metabolism, Quetiapine Fumarate pharmacology, Receptor, Serotonin, 5-HT1A drug effects, Schizophrenia complications, Schizophrenia metabolism
Abstract

The cognitive impairment associated with schizophrenia is highly prevalent and affects the overall functioning of subjects. The stimulation of the serotonin 1A receptor is a primary characteristic of some atypical antipsychotic drugs. We measured the levels of cognitive impairment using the Morris water maze test and protein kinase A activity in hippocampal neurons on presynaptic and postsynaptic serotonin 1A receptors to investigate the effect of dizocilpine-induced cognitive impairment associated with atypical antipsychotic drugs in rats treated by quetiapine alone or combined with WAY100635/tandospirone. The results of the Morris water maze test presented evidence that quetiapine alone alleviated the cognitive impairment associated with atypical antipsychotic drugs induced by dizocilpine. However, quetiapine plus WAY100635 induced no improvement of cognitive impairment associated with atypical antipsychotic drugs. The results of protein kinase A assay suggested that neither quetiapine alone nor in combination with tandospirone, but not quetiapine plus WAY100635, raised protein kinase A activity in hippocampus neurons. The present study demonstrated the key role of presynaptic serotonin 1A receptors on the therapeutic effect of quetiapine on cognitive impairment associated with atypical antipsychotic drugs. Moreover, that protein kinase A activity in hippocampal cells is involved in the mechanism of quetiapine's effect on cognitive impairment associated with atypical antipsychotic drugs., Competing Interests: The authors declare no conflict of interest., (©2019 Han et al. Published by IMR press. All rights reserved.)

Published
2019
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31. Relationship between apathy and tumor location, size, and brain edema in patients with intracranial meningioma.

Author

Peng Y, Shao C, Gong Y, Wu X, Tang W, and Shi S

Abstract

Background: The purpose of this study is to assess the relationship between apathy and tumor location, size, and brain edema in patients with intracranial meningioma., Methods: We enrolled 65 consecutive patients with meningioma and 31 normal controls matched for age, gender, and education. The patients were divided into frontal or non-frontal (NF) meningioma groups based on magnetic resonance imaging; the frontal group was then subdivided to dorsolateral frontal (DLF), medial frontal (MF), and ventral frontal (VF) groups. Tumor size and brain edema were also recorded. Apathy was assessed by the Apathy Evaluation Scale (AES). Assessments were carried out 1 week before and 3 months after surgery, respectively. Logistic regression analysis was performed to identify the predictive effect of tumor size, location, and brain edema on apathy. Analysis of variance and chi-square analysis were applied to compare apathy scores and apathy rates among the frontal, NF, and normal control groups, and all subgroups within the frontal group., Results: Compared with the NF and control groups, the mean AES score was much higher in the frontal group (34.0±8.3 versus 28.63±6.0, P=0.008, and 26.8±4.2, P<0.001). Subgroup analysis showed that AES scores in the MF group (42.1±6.6) and VF group (34.7±8.0) were higher than in the DLF group (28.5±4.36), NF group, and control group (P<0.05). The apathy rate was 63.6% in the MF group and 25% in the VF group, and significantly higher than in the DLF (5.6%), NF (5.3%), and control (0%) groups (P<0.001). A moderate correlation was found between AES score and mean diameter of the meningioma in all patient groups. Further analysis demonstrated that the correlation existed in the DLF (r=0.52, P=0.032), MF (r=0.84, P<0.001), and VF (r=0.64, P=0.008) groups, but not in the NF group (r=0.19, P=0.448). The AES score was much higher in patients with brain edema than in those without brain edema (34.73±8.28 versus 28.77±4.20, t=3.545, P=0.001). In subgroups within frontal meningioma patients, the statistical significance above only existed in the MF group (43.50±5.26 versus 25.67±6.03, P=0.001). Also, we examined the effect of related factors, such as age, sex, education, tumor size, tumor location and edema on the occurrence of apathy. The binary logistic regression analysis showed that MF [P=0.023, Exp(B) =145.6] and size [P=0.012, Exp(B) =1.20] got into the regression equation. Thirty-two patients underwent follow-up post-surgery. A significant reduction in AES was found in the MF group (AES1 - AES2 =6.86±6.82, t=2.68, P=0.04), but not in any of the other groups., Conclusion: Apathy occurs frequently in patients with frontal meningioma, and is more severe, especially in the MF region. Apathy is probably correlated with tumor location and size. Brain edema might increase the severity of apathy.

Published
2015
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32. Differential attentional bias in generalized anxiety disorder and panic disorder.

Author

Chen J, Wang Z, Wu Y, Cai Y, Shen Y, Wang L, and Shi S

Abstract

Background: Cognitive theorists relate anxiety disorders to the way in which emotional information is processed. The existing research suggests that patients with anxiety disorders tend to allocate their attention toward threat-related information selectively, and this may differ among different types of anxious subjects. The aim of this study was to explore attentional bias in patients with generalized anxiety disorder (GAD) and panic disorder (PD) using the emotional Stroop task and compare the differences between them., Methods: Forty-two patients with GAD, 34 patients with PD, and 46 healthy controls performed the emotional Stroop task with four word types, ie, GAD-related words, PD-related words, neutral words, and positive words., Results: Patients with GAD and those with PD were slower than healthy controls to respond to all stimuli. Patients with GAD had longer response latencies in color-naming both PD-relevant words and GAD relevant words. Patients with PD had longer response latencies only in color-naming PD-related words, similar to healthy controls., Conclusion: Patients with GAD and those with PD had a different pattern of attentional bias, and there was insufficient evidence to support the existence of specific attentional bias in patients with PD.

Published
2013
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33. Meta-analysis of studies in China about changes in P300 latency and amplitude that occur in patients with schizophrenia during treatment with antipsychotic medication.

Author

Su L, Cai Y, Shi S, and Wang L

Abstract

Background: Studies using event-related potential (ERP) methods have reported a relationship between the cognitive dysfunction of patients with schizophrenia and P300 latency and amplitude, but it remains uncertain whether or not these indices change as cognitive functioning improves with pharmacological treatment., Aim: Pool the results from follow-up studies conducted in China to determine the relationship of treatment with antipsychotic medication to changes in P300 indices., Methods: Studies conducted in China and published in English or Chinese from January 1982 to December 2011 that reported P300 latency and amplitude in patients with schizophrenia before and after treatment with antipsychotic medications were identified by electronic and hand searches, and the 12 studies that met inclusion criteria for the meta-analysis were independently reviewed by two evaluators. The peak P300 amplitude results for the 17 samples reported in the 12 studies were homogenous so a fixed-effects model was used to assess pooled standardized effect size (PSES); but the results for P300 latency were heterogeneous so a random-effects model was used to compute PSES. Publication bias was assessed using Egger's test, Begg's test and funnel plots., Results: Of the pooled sample of 611 participants, the 502 participants (82.2%) who completed P300 latency and amplitude measures both before and after treatment were included in the meta-analysis. We found that antipsychotic treatment is associated with a small but significant increase in the amplitude of P300 (PSES=0.39, 95% CI [0.26, 0.51], z=6.14, p<0.001) and a small but significant decrease in the latency of P300 (PSES= -0.29, 95% CI [-0.51, -0.07]; z=2.58; p=0.010). There was no significant publication bias in either of the results., Conclusion: In contrast to meta-analysis from western countries - that are primarily based on cross-sectional studies - the current meta-analysis of follow-up treatment studies of schizophrenia in China found that P300 amplitude and latency both change with pharmacological treatment. These findings suggest that P300 indices, particularly P300 amplitude, could be valuable biomarkers to monitor changes in cognitive functioning during treatment of patients with schizophrenia.

Published
2012
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34. A review of neuroimaging studies of anxiety disorders in China.

Author

Chen J and Shi S

Abstract

Background: Anxiety disorders are highly prevalent internationally, and constitute a substantial social and economic burden for patients, their families, and society. A number of neuroimaging studies have investigated the etiology of anxiety disorders in China in the last decade. We discuss the findings of these studies, and compare them with the results of neuroimaging studies of anxiety disorders outside China., Method: A literature search was conducted using the Chinese BioMedical Literature Database, the Chinese Scientific and Technical Periodicals Database, the Chinese Journal Full-text Database, and PubMed, from 1989 to April 2009. We selected neuroimaging studies in which all participants and researchers were Chinese., Results: Twenty-five studies fit our inclusion criteria. Nine studies examined general anxiety disorder (GAD) and/or panic disorder (PD), eight examined obsessive-compulsive disorder (OCD), and eight examined posttraumatic stress disorder (PTSD). Our literature review revealed several general findings. First, reduced regional cerebral blood flow (rCBF) was found in the frontal lobe and temporal lobe in patients with GAD and PD compared with healthy controls. Second, when viewing images with negative and positive valence, relatively increased or decreased activation was found in several brain areas in patients with GAD and PD, respectively. Third, studies with positron emission tomography (PET) and magnetic resonance spectroscopy (MRS) imaging revealed that OCD patients exhibited hyperperfusion and hypoperfusion in some brain regions compared with healthy controls. Neuroimaging studies of PTSD indicate that the hippocampal volume and the N-acetylaspartic acid (NAA) level and the NAA/creatine ratio in the hippocampus are decreased in patients relative to controls., Conclusion: Neuroimaging studies within and outside China have provided evidence of specific neurobiological changes associated with anxiety disorders. However, results have not been entirely consistent across different studies of patients with the same diagnoses. International collaborative research using large samples and robust designs should be conducted in future.

Published
2011
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