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Your search keyword '"Shaheen, Ihab"' showing total 11 results
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1. Egyptian pediatric kidney transplantation: highlights on post-transplant follow-up and management of complications by the Egyptian Pediatric Clinical Practice Guidelines Committee (EPG) Nephrology Group

Author

Moustafa, Bahia, Soliman, Neveen A., Shaheen, Ihab, Badr, Ahmed, Atia, Fatma M., El Hatw, Mohamed K., Mogahed, Engy Adel, EL-Ghamrawy, Mona, El Khashab, Khaled, Shaheen, Noha, Shouman, Mohamad G., Selim, Abeer, El-Sharkawy, Magdy, El Azeem, Tarek Abd, Esmat, Mohamad, Salman, Manal, Ali-El-Dein, Bedeir, Rahim, Mona Abdel, El-Hadedy, Muhamed A., Ghoneim, Moatasem Elsayed, Korkor, Mai S., Omar, Tarek E. I., Amer, Yasser, and Baky, Ashraf Abdel

Published
2024
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3. Recurrent Focal Segmental Glomerulosclerosis After Kidney Transplantation in African Americans: Review of the Current Evidence

Author

Shaheen Ihab, Umeizudike I Theophilus, Jenkins R John, and Halawa Ahmed

Subjects
Male, medicine.medical_specialty, Apolipoprotein L1, Population, Focal segmental glomerulosclerosis, Recurrence, Diabetes mellitus, Internal medicine, medicine, Humans, education, Kidney transplantation, Transplantation, education.field_of_study, biology, business.industry, Glomerulosclerosis, Focal Segmental, Glomerulonephritis, Odds ratio, medicine.disease, Kidney Transplantation, Black or African American, Treatment Outcome, biology.protein, Kidney Failure, Chronic, Female, business, Kidney disease
Abstract

Objectives In many countries of sub-Saharan Africa, the most common causes of end-stage kidney disease are hypertension, chronic glomerulonephritis, and diabetes mellitus. So far, literature on recurrent focal segmental glomerulosclerosis in sub-Saharan African populations is limited. With the intention of providing guidance for best practices in sub-Saharan Africa, we reviewed available evidence for African Americans, a population with a similar genetic background. We chose this population as a pseudo-population to show how similar genetic backgrounds can predict disease occurrence in similar populations residing in different continents. Materials and methods Our extended PubMed and Scopus literature search used these key words: "focal segmental glomerulosclerosis in African Americans" (search 1), "recurrent focal segmental glomerulosclerosis after kidney transplantation" (search 2), "risk factors for recurrent focal segmental glomerulosclerosis" (search 3); and "APOL1 gene and kidney transplantation" (search 4). Results/conclusions Search 1 yielded 4 articles, search 2 yielded 44 articles, search 3 yielded 6 articles, and search 4 yielded 8 articles. African Americans were shown to be disproportionately predisposed to endstage kidney disease, traceable to focal segmental glomerulosclerosis (the most common cause of glomerulonephritis leading to end-stage kidney disease). Apolipoprotein L1 presence in 22% of African Americans explained the odds ratio of 17 in developing focal segmental glomerulosclerosis and 8 times lifetime risk of end-stage kidney disease. Focal segmental glomerulosclerosis recurred in 30% of kidney transplant recipients; risk factors included young age, rapid progression to end-stage kidney disease, and White race recipient. Circulating permeability factors played a central role in primary and recurrent focal segmental glomerulosclerosis. For recurrent cases, transplant biopsy has remained the gold standard for diagnosis, with treatment involving a multi-modal approach, often resulting in partial or complete remission of proteinuria; allograft loss can occur if treatment is not successful. More randomized clinical trials are needed to chart the way forward for prolonged allograft function.

Published
2021

11. Acute renal failure in children: etiology, treatment and outcome.

Author

Shaheen IS, Watson AR, and Harvey B

Subjects
Adolescent, Adult, Child, Child, Preschool, Combined Modality Therapy, England epidemiology, Female, Hemofiltration, Humans, Infant, Infant, Newborn, Intensive Care Units, Pediatric, Male, Peritoneal Dialysis, Prospective Studies, Renal Dialysis, Renal Replacement Therapy, Treatment Outcome, Acute Kidney Injury etiology, Acute Kidney Injury mortality, Acute Kidney Injury therapy
Abstract

Children with acute renal failure (ARF) may be treated in pediatric renal or intensive care (PICU) units where there is an increasing use of continuous renal replacement therapies such as hemofiltration (HF). Over three years, we prospectively recorded details of all patients with ARF treated both within our regional pediatric renal unit, in two local neonatal intensive care units (NICUs), and one PICU, which are all supported by our institution. Our study included eighty-three ARF patients (43% male) with a median age of 5.7 years (range 1 day - 19.8 years); 41% of patients were < 2 years, 20% 2-5 years, 13% 5-10 years and 26% > 10 years of age. A total of 37 patients (45%) were treated in the renal unit versus 46 (55%) patients in NICU/PICU. The initial treatment modality was conservative in 33%, peritoneal dialysis (PD) in 23%, hemodialysis (HD) in 15%, HF in 28%, and isolated plasmafiltration in one percent of the patients. About 16% of the patients required more than one treatment modality. Outcome data at three months showed normal renal function in 49%, deaths in 20%, dialysis dependent disease in 14%, chronic renal failure (GFR < 60ml/min/1.73m2) in eight percent, and proteinuria and/or hypertension in seven percent of the patients. Only one (3%) death occurred in 37 patients treated in the renal unit compared to 16 deaths in 46 patients (35%) treated in the NICU/PICU. Our findings further confirm the low mortality rate with isolated renal failure and the substantial mortality and renal workload in intensive care areas where renal failure is often part of multi-organ failure. Further prospective studies will be required to analyze the impact of early hemofiltration in such patients.

Published
2006

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