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Motivation Multi-omic profiling data, such as The Cancer Genome Atlas and pharmacogenomic data, facilitate research into cancer mechanisms and drug development. However, it is not easy for researchers to connect, integrate and analyze huge and heterogeneous data, which is a major obstacle to the utilization of cancer genomic data. Results We developed Cancer Genome Viewer (CGV), a user-friendly web service that provides functions to integrate and visualize cancer genome data and pharmacogenomic data. Users can easily select and customize the samples to be analyzed with the pre-defined selection options for patients’ clinic-pathological features from multiple datasets. Using the customized dataset, users can perform subsequent data analyses comprehensively, including gene set analysis, clustering or survival analysis. CGV also provides pre-calculated drug response scores from pharmacogenomic data, which may facilitate the discovery of new cancer targets and therapeutics. Availability and implementation CGV web service is implemented with the R Shiny application at http://cgv.sysmed.kr and the source code is freely available at https://git.sysmed.kr/sysmed_public/cgv. Supplementary information Supplementary data are available at Bioinformatics online.

A study on the flora of Geomun Oreum, designated as a UNESCO World Natural Heritage Site, was surveyed in 2019. Vascular plants in this area revealed 310 taxa belonging to 90 families, 210 genera, 279 species, one subspecies, 27 varieties, and three formas. The Geomun Oreum showed low mean annual temperature, but it was confirmed that the emergence of warm-temperate plant species and evergreen broad-leaved forests was prominent. These results were interpreted to be due to a great deal of precipitation, many frost-free days, and the difference between the highest and lowest temperatures depending on the geographical characteristics of Geomun Oreum. Geomun Oreum is evaluated as a relatively natural habitat given the limited access of visitors and management, but it was confirmed that Sedum tosaense, a critically endangered species of the rare plants designated by the International Union for Conservation of Nature, requires conservation plans in the area.

Coronary artery fistula is an abnormal communication between the coronary artery and the cardiac chambers. In particular, an abnormal connection between the conus branch of the right coronary artery and the proximal left anterior descending coronary artery is defined as Vieussens’ arterial ring. Coronary artery fistulas are usually asymptomatic, but some can cause complications such as infective endocarditis. Here, we report a case of Vieussens’ arterial ring causing infective endocarditis with severe mitral regurgitation.

The explosive increase in the number of IoT devices requires various types of communication methods. This paper presents secure personal authentication using electrostatic coupling Intra-body communication (IBC) based on frequency shift keying (FSK) and error correction. The proposed architecture uses GPIO for a transmitter and analog-to-digital conversion (ADC) for a receiver. We mplemented FSK modulation, demodulation, data protection, and error correction techniques in the MCU software without applying hardware devices. We used the characteristic that the carrier signal is 50% duty square wave for 1-bit error correction and applied a method of randomly inverting SHA1 hash data to protect user authentication data during transmission. The transmitter modulates binary data using a square wave as a carrier signal and transmits data through the human body. The receiver demodulates the signal using ADC and decrypts the demodulated binary data. To determine the carrier frequency from ADC results, we applied a zero-crossing algorithm which is used to detect edge characteristics in image processing. When calculating the threshold value within the zero-crossing algorithm, we implemented an adaptive threshold setting technique utilizing Otsu&rsquo, s binarization technique. We found that the size of the electrode pad does not affect the signal strength, but the distance between the electrode pad and the skin has a significant effect on the signal strength. Our results show that binary data modulated with a square wave can be successfully transmitted through the human body, and, when 1-bit error correction is applied, the byte error rate on the receiver side is improved around 3.5% compared to not applying it.

Sialolithiasis, the most common salivary gland pathology, is caused by calculi in the gland itself and its duct. While patients with small sialoliths can undergo conservative treatment, those with standard-size or larger sialoliths require sialolithotomy. In the present case study, we removed two sialoliths located beneath the mucosa in the posterior and anterior regions of Wharton's duct, respectively. For the posterior calculus, we performed sialolithotomy via an intra-oral approach; thereafter, the small anterior calculus near the duct orifice was removed by hydraulic power. This method has not previously been reported. There were no complications either during the operation or postoperatively, and the salivary function of the gland remained normal.

This paper deals with the identification problem for the $L^1$-valued retarded functional differential equation. The unknowns are parameters and operators appearing in the given systems. In order to identify the parameters, we introduce the solution semigroup and the structural operators in the initial data space, and provide the representations of spectral projections and the completeness of generalized eigenspaces. The sufficient condition for the identification problem is given as the so called rank condition in terms of the initial values and eigenvectors of adjoint operator.

An 81-year-old male patient presented with complaint of a pulsating neck mass. The patient had a previous history of cervical lymphadenopathy by non-tuberculous mycobacterium infection. Rapid growth of the mass on admission and contrast enhanced computed tomography of the neck resulted in a diagnosis of non-tuberculous mycobacterium induced pseudoaneurysm. The patient underwent emergency open repair of the pseudoaneurysm. Pseudoaneurysm of the common carotid artery is regularly reported, but here we report a rare case of non-tuberculous mycobacterium induced pseudoaneurysm of the common carotid artery.

Cuticle micromorphology of all eight species of Fagus and an outgroup were examined in the present study. The genus Trigonobalanus was selected as the outgroup. Thirteen characteristics of the inner surface and five of the outer surface of the cuticle were described. Some characteristics, such as the subsidiary cell shape, size of stomata, arrangement of subsidiary cell, shape of anticlinal and periclinal cell walls, texture of periclinal cell wall, development epicuticular wax, and presence of papillae, were considered important for infrageneric classification. The topology was obtained from the analysis using two major lineages: (1) Fagus engleriana + Fagus japonica + Fagus longipetiolata and (2) Fagus sylvatica + Fagus crenata + Fagus lucida + Fagus hayatae + Fagus grandifolia. The first clade supported a bootstrap value of 98% and the second clade a bootstrap value of 97%. Based on the cuticle morphology, our results support the previous study, by revealing F. engleriana, F. japonica, and F. longipetiolata with long peduncles in one group and the remaining extant species of short- to medium-length peduncles in another group. In addition, molecular phylogenetic study of Fagus based on ribosomal DNA ITS and chloroplast DNA sequences data supports this assemblage. This study shows that cuticle micromorphological characteristics provide useful and important information for analyzing the evolutionary aspects of Fagus.

Anticoagulation therapy is essential after cardiac valve surgery. However, spontaneous bleeding remains a major concern during anticoagulation therapy. Spontaneous gallbladder (GB) hemorrhage (hemobilia) is a rare occurrence during standard anticoagulation therapy. This report presents a case of GB hemorrhage that occurred shortly after initiating oral anticoagulant therapy in a patient who had undergone mitral valve replacement surgery.

We present a 25-Gb/s optical transmitter composed of a Si ring modulator and CMOS driver circuit. The Si ring modulator is realized with 220-nm Si-on-insulator process and the driver circuit with 65-nm CMOS process. The modulator and the driver are hybrid-integrated on the printed circuit board with bonding wires. The driver is designed so that the parasitic bonding wire inductance provides enhanced driver bandwidth. The transmitter successfully demonstrates 25-Gb/s operation.

Primary epithelial-myoepithelial carcinoma (EMC) of the lung is an extremely rare neoplasm that originates from submucosal bronchial glands and has been found in the salivary glands, breast tissue, and sweat glands. However, only a few cases in the respiratory tract have been identified. In the literature, most pulmonary EMCs have been reported to have developed endobronchially although a few EMC cases have been presented as intraparenchymatous tumors. We have identified a case of primary EMC that developed in the peripheral lung parenchyma.

경제 선진화에 따라 GDP중 서비스 산업의 비중은 점점 커지고 있다. 서비스 산업 발전은 고용 문제 해결과 내수 시장의 활성화를 유도하며, 의료, 교육, 문화 등의 수요 창출, 제조업의 경쟁력 강화 및 경제 전반에 발전을 기여할 것이다. 정보통신 기술의 발전과 그에 따른 삶의 질 향상, 그리고 글로벌 무한 경쟁 등 경쟁 환경 변화 등으로 기업, 공공 기관 등의 소비자 또는 고객의 욕구는 날로 증대되고 있다. 이러한 환경 속에서 기업 등은 고객과의 소통, 고객 불만 처리, 신규 고객 유치 및 유지 등의 목적으로 비대면 접점인 콜센터를 운영하고 있다. 본 연구는 비대면 접점인 콜센터의 성과 제고를 위하여 서비스 및 프로세스 개요, 업무 성과 평가, 콜센터 평가 등에 관한 연구를 통하여 문제점을 분석하고 콜센터의 ‘서비스 프로세스 모델링’ 및 향후 정책과제를 도출하고자 한다.

We report a rare case of an extremely large right ventricular myxoma involving the ventricular side of the tricuspid valve. The tumor was excised along with the entire posterior leaflet and part of the anterior leaflet. The tricuspid valve was repaired by sliding valvuloplasty combined with ring annuloplasty.

Those studies in the field of Management Information Systems and the Success Model of the DeLone and McLean`s Information Systems suggest that some factors related to information systems should be developed and operated to affect the performance of the user`s personal and companies through the introduction and use of corporate information systems. The purpose of this study is put on searching for some factors which impact on user satisfaction about the customer information management systems of call center. We did conduct on a survey of 539 people who are working as a call center counseling employees as setting up a structural equation model which reflects previous research on working environment and job satisfaction, and modified DeLone and McLean`s information system success model. The results of this study are as follows. First, seven of the eleven hypotheses that three quality of the information systems might be affecting working environment, job satisfaction, user satisfaction were adopted Second, we confirmed that the working environment works as a the partial mediation and the quality of services works as a fully mediation between system/information quality and users` satisfaction. The implications of this study are that it is necessary not only to make a good working environment but also to keep improving it in order to boost the operational performance of information systems in the future.

Background: The conventional method of aortic cross-clamping is very difficult and increases the risk of cerebral infarct due to embolism of the calcified aorta in these patients. Accordingly, we analyzed our experience with 11 cases of ascending aorta and aortic valve replacement with hypothermic circulatory arrest. Materials and Methods: From January 2002 to December 2009, 11 patients had ascending aorta and aortic valve replacement with hypothermic arrest at our hospital. We performed a retrospective study. Results: There were 5 males and 6 females, with a mean age of 68 years (range, 44 to 82 years). Eight patients had aortic stenosis, and 3 patients had aortic regurgitation. An aortic cannula was inserted into the right axillary artery in 3 patients and ascending aorta in 6 patients. Two patients with aortic regurgitation had a remote access perfusion catheter inserted though the right femoral artery. The mean cardiopulmonary bypass time was 180 minutes (range, 110 to 306 minutes) and mean hypothermic circulatory arrest time was 30 minutes (range, 20 to 48 minutes). The mean rectal temperature during hypothermic circulatory arrest was 21℃ (range, 19℃ to 23℃). No patient had any new onset of cerebral infarct or cardiovascular accident after surgery. There was no hospital mortality. Early complications occurred in 1 patient who needed reoperation due to postoperative bleeding. Late complications occurred in 1 patient who underwent a Bentall operation due to prosthetic valve endocarditis. The mean follow-up duration was 32 months (range, 1 month to 8 years) and 1 patient died suddenly due to unknown causes after 5 years. Conclusion: Patients with a calcified aorta can be safely treated with a technique based on aorta and aortic valve replacement under hypothermic circulatory arrest.

Vieussens' arterial ring (VAR) is the connection between the conus branch of the right coronary artery and the proximal right ventricular branch of the left anterior descending coronary artery. VARs are found in 48% of the population; however, pathologic VAR is rare. We experienced a case of pathologic VAR that involved a fistula connecting to the main pulmonary artery.

Two stents were placed across the right subclavian vein due to stenosis of the right subclavian vein in a 40-year-old patient with chronic renal failure on hemodialysis. During the follow up period, one of stents migrated into the right ventricle inducing tricuspid valve insufficiency. Percutaneous stent removal had failed and the stent was removed by open heart surgery with Tricuspid valve repair with a good result, and then we report the case.

In this exploratory paper, the dynamic stock return method (DSRM) initially proposed as an effective and replicable method by [14], [4], [5], [6] is deliberately applied to the US airline industry over the period from 1979 to 1992 (14 years). The longitudinal categorization or strategic group (SG) results from the DSRM show good face validity. They are consistent with the industry’s fact-based historical progress. We also observe that the operational measures such as market share or productivity tend to support the grouping results. Furthermore, the results of 15- and 7-year analysis of relative closeness of stock responsive movements between two representative airline firms (American and Hawaiian airlines, respectively) could be inferred that the SGs derived from the DSRM are valid and robust over a longer time span. We conclude that the DSRM could be a good alternative instrument for the longitudinal study of industry substructure.

A two-step heating process, long low temperature-short high temperature cooking cycle, is used to maximize fat reduction in roast beef. First, the beef was cooked at a low temperature for a long time; then, it was cooked at a higher temperature for a short time. The study examines cooking loss, fat content, texture, and inosine 5’-monophosphate (IMP) production of cooked meat under different heating conditions. In an oven, the internal temperature of the meat increased to a transition point of 48 or 54°C at oven temperatures of 80 or 100°C and reached 60°C at 220°C. The fat was reduced by up to 44.2% compared to 27.8% under conventional roasting conditions. In addition, the two-step heating process kept the meat tender and juicy but improved IMP content.

The roller bearings play an important role not only sustain radial or axial load of system, but carry out a rotatory movement as a various operating conditions. They happen that incipient faults which were caused by excessive load, manufacturing or assembling process`s errors and many other reasons are created. The bearing faults make noise and vibration by a continuous collision of rotatory components, which can lower the quality and stability of auto-transmission. Therefore, it is important to detect the early fault as soon as possible. This paper presents a detecting method for the improvement in quality by developing the program which can be used to analyze and predict the vibrational characteristics caused by roller bearing faults. We completed development of the inspection system of vibration by applying the most efficient detecting methods and verified the system`s reliability through experiments.

Cuticle micromorphology of 22 species of Quercus and outgroup were examined by the SEM. Twenty-two species selected each two or three species in all section of the genus Quercus. The genus Trigonobalanus and Alnus are selected as outgroups. Ten characters of the inner surface and eight characters of the outer surface of the cuticle have been described. Some characters, such as the present of papillae, arrangement of subsidiary cell, shape of anticlinal cell wall are considered important character for infrageneric classification. A parsimony analysis of 18 characters resulted in 72 most parsimonious trees with its lengths of 66 steps. The topology obtained from the analysis showed two major lineages. Subgenus Cyclobalanopsis formed one clade by 75% and subgenus Quercus formed another clade by 57% bootstrap value. Based on the cuticle morphology, the two subgenus delimitation of Camus was supported. However, sect. Erythrobalanus and sect. Cerris formed one group, and sect. Lepidobalanus formed polytomy.

The chemical resistance of textile geogrids to alkaline conditions was studied. From the results, textile geogrids manufactured from PET yarn show strong resistance in the case of light alkaline condition (pH 9) at room temperature. However, under severe alkaline conditions at high temperature the raw mechanical properties could not be maintained. From the results, strength retention after chemical degradation was calculated and used to determine the reduction factor for application in revetment reinforcement design.

This case series study demonstrates the possibility of successful implant rehabilitation without bone augmentation in the atrophic posterior maxilla with cystic lesion in the sinus. Sinus lift without bone graft using the lateral approach was performed. In one patient, the cyst was aspirated and simultaneous implantation under local anesthesia was performed, whereas the other cyst was removed under general anesthesia, and the sinus membrane was elevated in a second process, followed by implantation. In both cases, tapered 11.5-mm-long implants were utilized. With all of the implants, good stability and appropriate bone height were achieved. The mean bone level gain was 5.73 mm; adequate bone augmentation around the implants was shown, the sinus floor was moved apically, and the cyst was no longer radiologically detected. Completion of all of the treatments required an average of 12.5 months. The present study showed that sufficient bone formation and stable implantation in a maxilla of insufficient bone volume are possible through sinus lift without bone materials. The results serve to demonstrate, moreover, that surgical treatment of mucous retention cyst can facilitate rehabilitation. These techniques can reduce the risk of complications related to bone grafts, save money, and successfully treat antral cyst.

Anomalous origin of a coronary aortic artery is a rare cardiac anomaly. Although it can cause angina, syncope, and palpitations, most patients are asymptomatic. This anomaly requires surgical treatment or intervention because it is associated with sudden death. Several surgical techniques, such as coronary reimplantation, coronary artery bypass grafting (CABG), unroofing, and neo-ostium formation, have been proposed as treatments. We report a case surgically treated with neo-ostium formation in anomalous origin of the left coronary artery from the right coronary sinus.

We construct some results on the regularity of solutions and the approximate controllability for neutral functional differential equations with unbounded principal operators in Hilbert spaces. In order to establish the controllability of the neutral equations, we first consider the existence and regularity of solutions of the neutral control system by using fractional power of operators and the local Lipschitz continuity of nonlinear term. Our purpose is to obtain the existence of solutions and the approximate controllability for neutral functional differential control systems without using many of the strong restrictions considered in the previous literature. Finally we give a simple example to which our main result can be applied.