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21,779 results on '"Scott, John"'

1. Hydrogen plasma inhibits ion beam restructuring of materials

Author

Scott, John A., Bishop, James, Budnik, Garrett, and Toth, Milos

Subjects
Physics - Applied Physics, Physics - Instrumentation and Detectors
Abstract

Focused ion beam (FIB) techniques are employed widely for nanofabrication, and processing of materials and devices. However, ion irradiation often gives rise to severe damage due to atomic displacements that cause defect formation, migration and clustering within the ion-solid interaction volume. The resulting restructuring degrades the functionality of materials, and limits the utility FIB ablation and nanofabrication techniques. Here we show that such restructuring can be inhibited by performing FIB irradiation in a hydrogen plasma environment via chemical pathways that modify defect binding energies and transport kinetics, as well as material ablation rates. The method is minimally-invasive and has the potential to greatly expand the utility of FIB nanofabrication techniques in processing of functional materials and devices.

Published
2024

2. Evidence of the Monopolar-Dipolar Crossover Regime: A Multiscale Study of Ferroelastic Domains by In-Situ Microscopy Techniques

Author

Scott, John J R, Lu, Guangming, Rodriguez, Brian J., MacLaren, Ian, Salje, Ekhard K. H., and Arredondo, Miryam

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

The elastic interaction between kinks (and antikinks) within domain walls plays a pivotal role in shaping the domain structure, and their dynamics. In bulk materials, kinks interact as elastic monopoles, dependent on the distance between walls, and typically characterised by a rigid and straight domain configuration. In this work we investigate the evolution of the domain structure as the sample size decreases, by means of in-situ heating techniques on free-standing samples. A significant transformation is observed: domain walls exhibit pronounced curvature, accompanied by an increase in both domain wall and junction density. This transformation is attributed to the pronounced influence of kinks, inducing sample warping, where 'dipole dipole' interactions are dominant. Moreover, we experimentally identify a critical thickness range that delineates a cross-over between the monopolar and dipolar regimens and corroborated this by detailed atomic simulations. These findings are relevant for in-situ TEM studies and for the development of novel devices based on free-standing ferroic thin films and nanomaterials.

Published
2024
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3. Fatal Infections Differentially Involve Allograft and Native Lungs in Single Lung Transplant Recipients

Author

Villalba, Julian A., Cheek-Norgan, E. Heidi, Johnson, Tucker F., Yi, Eunhee S., Boland, Jennifer M., Aubry, Marie-Christine, Pennington, Kelly M., Scott, John P., and Roden, Anja C.

Subjects
Lungs -- Transplantation, Respiratory tract infections -- Risk factors -- Development and progression, Health
Abstract

* Context.--Respiratory infections complicate lung transplantation and increase the risk of allograft dysfunction. Allograft lungs may have different susceptibilities to infection than native lungs, potentially leading to different disease severity in lungs of single lung transplant recipients (SLTRs). Objective.--To study whether infections affect allograft and native lungs differently in SLTRs but similarly in double LTRs (DLTRs). Design.--Using an institutional database of LTRs, medical records were searched, chest computed tomography studies were systematically reviewed, and histopathologic features were recorded per lung lobe and graded semiquantitatively. A multilobar-histopathology score (MLHS) including histopathologic data from each lung and a bilateral ratio ([MLHS.sub.ratio]) comparing histopathologies between both lungs were calculated in SLTRs and compared to DLTRs. Results.--Six SLTRs died of infection involving the lungs. All allografts showed multifocal histopathologic evidence of infection, but at least 1 lobe of the native lung was uninvolved. In 4 of 5 DLTRs, histopathologic evidence of infection was seen in all lung lobes. On computed tomography, multifocal ground-glass and/or nodular opacities were found in a bilateral distribution in all DLTRs but in only 2 of 6 SLTRs. In SLTRs, the [MLHS.sub.Allograft] was higher than [MLHS.sub.Native] (P = .02). The [MLHS.sub.ratio] values of SLTR and DLTR were significantly different (P < .001). Conclusions.--Allograft and native lungs appear to harbor different susceptibilities to infections. The results are important for the management of LTRs. doi: 10.5858/arpa.2023-0227-OA), The median overall survival of lung transplant recipients (LTRs) is only 6.7 years, which is shorter than for other solid organ transplantations. (1) Noncytomegalovirus (nonCMV) infections play a major role [...]

Published
2024
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4. Index

Author

Scott, John and Bromley, Ray

Published
2013

6. Notes

Author

Scott, John and Bromley, Ray

Published
2013

7. References

Author

Scott, John and Bromley, Ray

Published
2013

19. List of Tables

Author

Scott, John and Bromley, Ray

Published
2013

20. Contents

Author

Scott, John and Bromley, Ray

Published
2013

22. The statistics and sensitivity of axion wind detection with the homogeneous precession domain of superfluid helium-3

Author

Foster, Joshua W., Gao, Christina, Halperin, William, Kahn, Yonatan, Mande, Aarav, Nguyen, Man, Schütte-Engel, Jan, and Scott, John William

Subjects
High Energy Physics - Phenomenology, Condensed Matter - Superconductivity, High Energy Physics - Experiment
Abstract

The homogeneous precession domain (HPD) of superfluid $^{3}$He has recently been identified as a detection medium which might provide sensitivity to the axion-nucleon coupling $g_{aNN}$ competitive with, or surpassing, existing experimental proposals. In this work, we make a detailed study of the statistical and dynamical properties of the HPD system in order to make realistic projections for a full-fledged experimental program. We include the effects of clock error and measurement error in a concrete readout scheme using superconducting qubits and quantum metrology. This work also provides a more general framework to describe the statistics associated with the axion gradient coupling through the treatment of a transient resonance with a non-stationary background in a time-series analysis. Incorporating an optimal data-taking and analysis strategy, we project a sensitivity approaching $g_{aNN} \sim 10^{-12}$ GeV$^{-1}$ across a decade in axion mass., Comment: 18 pages, 8 figures

Published
2023

23. Instant Photorealistic Style Transfer: A Lightweight and Adaptive Approach

Author

Liu, Rong, Zhao, Enyu, Liu, Zhiyuan, Feng, Andrew, and Easley, Scott John

Subjects
Computer Science - Computer Vision and Pattern Recognition, Electrical Engineering and Systems Science - Image and Video Processing
Abstract

In this paper, we propose an Instant Photorealistic Style Transfer (IPST) approach, designed to achieve instant photorealistic style transfer on super-resolution inputs without the need for pre-training on pair-wise datasets or imposing extra constraints. Our method utilizes a lightweight StyleNet to enable style transfer from a style image to a content image while preserving non-color information. To further enhance the style transfer process, we introduce an instance-adaptive optimization to prioritize the photorealism of outputs and accelerate the convergence of the style network, leading to a rapid training completion within seconds. Moreover, IPST is well-suited for multi-frame style transfer tasks, as it retains temporal and multi-view consistency of the multi-frame inputs such as video and Neural Radiance Field (NeRF). Experimental results demonstrate that IPST requires less GPU memory usage, offers faster multi-frame transfer speed, and generates photorealistic outputs, making it a promising solution for various photorealistic transfer applications., Comment: 8 pages (reference excluded), 6 figures, 4 tables

Published
2023

24. Disposable face masks: a direct source for inhalation of microplastics

Author

Prada, Andres F., Distler, Avram, Cheng, Shyuan, Scott, John W., Chamorro, Leonardo P., Subramanian, Ganesh, Verma, Vishal, and Turner, Andrew

Subjects
Physics - Medical Physics, Physics - Fluid Dynamics
Abstract

Surgical masks have played a crucial role in healthcare facilities to protect against respiratory and infectious diseases, particularly during the COVID-19 pandemic. However, the synthetic fibers, mainly made of polypropylene, used in their production may adversely affect the environment and human health. Recent studies have confirmed the presence of microplastics and fibers in human lungs and have related these synthetic particles with the occurrence of pulmonary ground glass nodules. Using a piston system to simulate human breathing, this study investigates the role of surgical masks as a direct source of inhalation of microplastics. Results reveal the release of particles of sizes ranging from nanometers (300 nm) to millimeters (~2 mm) during normal breathing conditions, raising concerns about the potential health risks. Notably, large visible particles (> 1 mm) were observed to be ejected from masks with limited wear after only a few breathing cycles. Given the widespread use of masks by healthcare workers and the potential future need for mask usage by the general population during seasonal infectious diseases or new pandemics, developing face masks using safe materials for both users and the environment is imperative., Comment: 11 pages, 3 figures

Published
2023

25. Estimands in Real-World Evidence Studies

Author

Chen, Jie, Scharfstein, Daniel, Wang, Hongwei, Yu, Binbing, Song, Yang, He, Weili, Scott, John, Lin, Xiwu, and Lee, Hana

Subjects
Statistics - Applications
Abstract

A Real-World Evidence (RWE) Scientific Working Group (SWG) of the American Statistical Association Biopharmaceutical Section (ASA BIOP) has been reviewing statistical considerations for the generation of RWE to support regulatory decision-making. As part of the effort, the working group is addressing estimands in RWE studies. Constructing the right estimand -- the target of estimation -- which reflects the research question and the study objective, is one of the key components in formulating a clinical study. ICH E9(R1) describes statistical principles for constructing estimands in clinical trials with a focus on five attributes -- population, treatment, endpoints, intercurrent events, and population-level summary. However, defining estimands for clinical studies using real-world data (RWD), i.e., RWE studies, requires additional considerations due to, for example, heterogeneity of study population, complexity of treatment regimes, different types and patterns of intercurrent events, and complexities in choosing study endpoints. This paper reviews the essential components of estimands and causal inference framework, discusses considerations in constructing estimands for RWE studies, highlights similarities and differences in traditional clinical trial and RWE study estimands, and provides a roadmap for choosing appropriate estimands for RWE studies.

Published
2023

26. A technology-enabled multi-disciplinary team-based care model for the management of Long COVID and other fatiguing illnesses within a federally qualified health center: protocol for a two-arm, single-blind, pragmatic, quality improvement professional cluster randomized controlled trial.

Author

Samaniego, Jane, Sharp, Sydney, Taren, Douglas, Zuber, Alexandra, Armistad, Amy, Dezan, Amanda, Leyba, Azure, Friedly, Janna, Bunnell, Aaron, Matthews, Eva, Miller, Maureen, Unger, Elizabeth, Bertolli, Jeanne, Hinckley, Alison, Lin, Jin-Mann, Scott, John, Struminger, Bruce, Ramers, Christian, and Godino, Job

Subjects
Chronic fatigue syndrome (CFS), Long COVID, Myalgic encephalomyelitis (ME), Post COVID-19 conditions (PCC), Post-infectious fatiguing illnesses (PIFI), Humans, COVID-19, SARS-CoV-2, Post-Acute COVID-19 Syndrome, Fatigue Syndrome, Chronic, Prospective Studies, Muscle Fatigue, Quality Improvement, Single-Blind Method, Randomized Controlled Trials as Topic
Abstract

BACKGROUND: The clinical burden of Long COVID, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and other post-infectious fatiguing illnesses (PIFI) is increasing. There is a critical need to advance understanding of the effectiveness and sustainability of innovative approaches to clinical care of patients having these conditions. METHODS: We aim to assess the effectiveness of a Long COVID and Fatiguing Illness Recovery Program (LC&FIRP) in a two-arm, single-blind, pragmatic, quality improvement, professional cluster, randomized controlled trial in which 20 consenting clinicians across primary care clinics in a Federally Qualified Health Center system in San Diego, CA, will be randomized at a ratio of 1:1 to either participate in (1) weekly multi-disciplinary team-based case consultation and peer-to-peer sharing of emerging best practices (i.e., teleECHO (Extension for Community Healthcare Outcomes)) with monthly interactive webinars and quarterly short courses or (2) monthly interactive webinars and quarterly short courses alone (a control group); 856 patients will be assigned to participating clinicians (42 patients per clinician). Patient outcomes will be evaluated according to the study arm of their respective clinicians. Quantitative and qualitative outcomes will be measured at 3- and 6-months post-baseline for clinicians and every 3-months post assignment to a participating clinician for patients. The primary patient outcome is change in physical function measured using the Patient-Reported Outcomes Measurement Information System (PROMIS)-29. Analyses of differences in outcomes at both the patient and clinician levels will include a linear mixed model to compare change in outcomes from baseline to each post-baseline assessment between the randomized study arms. A concurrent prospective cohort study will compare the LC&FIRP patient population to the population enrolled in a university health system. Longitudinal data analysis approaches will allow us to examine differences in outcomes between cohorts. DISCUSSION: We hypothesize that weekly teleECHO sessions with monthly interactive webinars and quarterly short courses will significantly improve clinician- and patient-level outcomes compared to the control group. This study will provide much needed evidence on the effectiveness of a technology-enabled multi-disciplinary team-based care model for the management of Long COVID, ME/CFS, and other PIFI within a federally qualified health center. TRIAL REGISTRATION: ClinicalTrials.gov, NCT05167227 . Registered on December 22, 2021.

Published
2023

27. The James Webb Space Telescope Mission

Author

Gardner, Jonathan P., Mather, John C., Abbott, Randy, Abell, James S., Abernathy, Mark, Abney, Faith E., Abraham, John G., Abraham, Roberto, Abul-Huda, Yasin M., Acton, Scott, Adams, Cynthia K., Adams, Evan, Adler, David S., Adriaensen, Maarten, Aguilar, Jonathan Albert, Ahmed, Mansoor, Ahmed, Nasif S., Ahmed, Tanjira, Albat, Rüdeger, Albert, Loïc, Alberts, Stacey, Aldridge, David, Allen, Mary Marsha, Allen, Shaune S., Altenburg, Martin, Altunc, Serhat, Alvarez, Jose Lorenzo, Álvarez-Márquez, Javier, de Oliveira, Catarina Alves, Ambrose, Leslie L., Anandakrishnan, Satya M., Andersen, Gregory C., Anderson, Harry James, Anderson, Jay, Anderson, Kristen, Anderson, Sara M., Aprea, Julio, Archer, Benita J., Arenberg, Jonathan W., Argyriou, Ioannis, Arribas, Santiago, Artigau, Étienne, Arvai, Amanda Rose, Atcheson, Paul, Atkinson, Charles B., Averbukh, Jesse, Aymergen, Cagatay, Bacinski, John J., Baggett, Wayne E., Bagnasco, Giorgio, Baker, Lynn L., Balzano, Vicki Ann, Banks, Kimberly A., Baran, David A., Barker, Elizabeth A., Barrett, Larry K., Barringer, Bruce O., Barto, Allison, Bast, William, Baudoz, Pierre, Baum, Stefi, Beatty, Thomas G., Beaulieu, Mathilde, Bechtold, Kathryn, Beck, Tracy, Beddard, Megan M., Beichman, Charles, Bellagama, Larry, Bely, Pierre, Berger, Timothy W., Bergeron, Louis E., Darveau-Bernier, Antoine, Bertch, Maria D., Beskow, Charlotte, Betz, Laura E., Biagetti, Carl P., Birkmann, Stephan, Bjorklund, Kurt F., Blackwood, James D., Blazek, Ronald Paul, Blossfeld, Stephen, Bluth, Marcel, Boccaletti, Anthony, Boegner Jr., Martin E., Bohlin, Ralph C., Boia, John Joseph, Böker, Torsten, Bonaventura, N., Bond, Nicholas A., Bosley, Kari Ann, Boucarut, Rene A., Bouchet, Patrice, Bouwman, Jeroen, Bower, Gary, Bowers, Ariel S., Bowers, Charles W., Boyce, Leslye A., Boyer, Christine T., Boyer, Martha L., Boyer, Michael, Boyer, Robert, Bradley, Larry D., Brady, Gregory R., Brandl, Bernhard R., Brannen, Judith L., Breda, David, Bremmer, Harold G., Brennan, David, Bresnahan, Pamela A., Bright, Stacey N., Broiles, Brian J., Bromenschenkel, Asa, Brooks, Brian H., Brooks, Keira J., Brown, Bob, Brown, Bruce, Brown, Thomas M., Bruce, Barry W., Bryson, Jonathan G., Bujanda, Edwin D., Bullock, Blake M., Bunker, A. J., Bureo, Rafael, Burt, Irving J., Bush, James Aaron, Bushouse, Howard A., Bussman, Marie C., Cabaud, Olivier, Cale, Steven, Calhoon, Charles D., Calvani, Humberto, Canipe, Alicia M., Caputo, Francis M., Cara, Mihai, Carey, Larkin, Case, Michael Eli, Cesari, Thaddeus, Cetorelli, Lee D., Chance, Don R., Chandler, Lynn, Chaney, Dave, Chapman, George N., Charlot, S., Chayer, Pierre, Cheezum, Jeffrey I., Chen, Bin, Chen, Christine H., Cherinka, Brian, Chichester, Sarah C., Chilton, Zachary S., Chittiraibalan, Dharini, Clampin, Mark, Clark, Charles R., Clark, Kerry W., Clark, Stephanie M., Claybrooks, Edward E., Cleveland, Keith A., Cohen, Andrew L., Cohen, Lester M., Colón, Knicole D., Coleman, Benee L., Colina, Luis, Comber, Brian J., Comeau, Thomas M., Comer, Thomas, Reis, Alain Conde, Connolly, Dennis C., Conroy, Kyle E., Contos, Adam R., Contreras, James, Cook, Neil J., Cooper, James L., Cooper, Rachel Aviva, Correia, Michael F., Correnti, Matteo, Cossou, Christophe, Costanza, Brian F., Coulais, Alain, Cox, Colin R., Coyle, Ray T., Cracraft, Misty M., Noriega-Crespo, Alberto, Crew, Keith A., Curtis, Gary J., Cusveller, Bianca, Maciel, Cleyciane Da Costa, Dailey, Christopher T., Daugeron, Frédéric, Davidson, Greg S., Davies, James E., Davis, Katherine Anne, Davis, Michael S., Day, Ratna, de Chambure, Daniel, de Jong, Pauline, De Marchi, Guido, Dean, Bruce H., Decker, John E., Delisa, Amy S., Dell, Lawrence C., Dellagatta, Gail, Dembinska, Franciszka, Demosthenes, Sandor, Dencheva, Nadezhda M., Deneu, Philippe, DePriest, William W., Deschenes, Jeremy, Dethienne, Nathalie, Detre, Örs Hunor, Diaz, Rosa Izela, Dicken, Daniel, DiFelice, Audrey S., Dillman, Matthew, Disharoon, Maureen O., van Dishoeck, Ewine F., Dixon, William V., Doggett, Jesse B., Dominguez, Keisha L., Donaldson, Thomas S., Doria-Warner, Cristina M., Santos, Tony Dos, Doty, Heather, Douglas Jr., Robert E., Doyon, René, Dressler, Alan, Driggers, Jennifer, Driggers, Phillip A., Dunn, Jamie L., DuPrie, Kimberly C., Dupuis, Jean, Durning, John, Dutta, Sanghamitra B., Earl, Nicholas M., Eccleston, Paul, Ecobichon, Pascal, Egami, Eiichi, Ehrenwinkler, Ralf, Eisenhamer, Jonathan D., Eisenhower, Michael, Eisenstein, Daniel J., Hamel, Zaky El, Elie, Michelle L., Elliott, James, Elliott, Kyle Wesley, Engesser, Michael, Espinoza, Néstor, Etienne, Odessa, Etxaluze, Mireya, Evans, Leah, Fabreguettes, Luce, Falcolini, Massimo, Falini, Patrick R., Fatig, Curtis, Feeney, Matthew, Feinberg, Lee D., Fels, Raymond, Ferdous, Nazma, Ferguson, Henry C., Ferrarese, Laura, Ferreira, Marie-Héléne, Ferruit, Pierre, Ferry, Malcolm, Filippazzo, Joseph Charles, Firre, Daniel, Fix, Mees, Flagey, Nicolas, Flanagan, Kathryn A., Fleming, Scott W., Florian, Michael, Flynn, James R., Foiadelli, Luca, Fontaine, Mark R., Fontanella, Erin Marie, Forshay, Peter Randolph, Fortner, Elizabeth A., Fox, Ori D., Framarini, Alexandro P., Francisco, John I., Franck, Randy, Franx, Marijn, Franz, David E., Friedman, Scott D., Friend, Katheryn E., Frost, James R., Fu, Henry, Fullerton, Alexander W., Gaillard, Lionel, Galkin, Sergey, Gallagher, Ben, Galyer, Anthony D., Marín, Macarena García, Gardner, Lisa E., Garland, Dennis, Garrett, Bruce Albert, Gasman, Danny, Gáspár, András, Gastaud, René, Gaudreau, Daniel, Gauthier, Peter Timothy, Geers, Vincent, Geithner, Paul H., Gennaro, Mario, Gerber, John, Gereau, John C., Giampaoli, Robert, Giardino, Giovanna, Gibbons, Paul C., Gilbert, Karolina, Gilman, Larry, Girard, Julien H., Giuliano, Mark E., Gkountis, Konstantinos, Glasse, Alistair, Glassmire, Kirk Zachary, Glauser, Adrian Michael, Glazer, Stuart D., Goldberg, Joshua, Golimowski, David A., Gonzaga, Shireen P., Gordon, Karl D., Gordon, Shawn J., Goudfrooij, Paul, Gough, Michael J., Graham, Adrian J., Grau, Christopher M., Green, Joel David, Greene, Gretchen R., Greene, Thomas P., Greenfield, Perry E., Greenhouse, Matthew A., Greve, Thomas R., Greville, Edgar M., Grimaldi, Stefano, Groe, Frank E., Groebner, Andrew, Grumm, David M., Grundy, Timothy, Güdel, Manuel, Guillard, Pierre, Guldalian, John, Gunn, Christopher A., Gurule, Anthony, Gutman, Irvin Meyer, Guy, Paul D., Guyot, Benjamin, Hack, Warren J., Haderlein, Peter, Hagan, James B., Hagedorn, Andria, Hainline, Kevin, Haley, Craig, Hami, Maryam, Hamilton, Forrest Clifford, Hammann, Jeffrey, Hammel, Heidi B., Hanley, Christopher J., Hansen, Carl August, Hardy, Bruce, Harnisch, Bernd, Harr, Michael Hunter, Harris, Pamela, Hart, Jessica Ann, Hartig, George F., Hasan, Hashima, Hashim, Kathleen Marie, Hashimoto, Ryan, Haskins, Sujee J., Hawkins, Robert Edward, Hayden, Brian, Hayden, William L., Healy, Mike, Hecht, Karen, Heeg, Vince J., Hejal, Reem, Helm, Kristopher A., Hengemihle, Nicholas J., Henning, Thomas, Henry, Alaina, Henry, Ronald L., Henshaw, Katherine, Hernandez, Scarlin, Herrington, Donald C., Heske, Astrid, Hesman, Brigette Emily, Hickey, David L., Hilbert, Bryan N., Hines, Dean C., Hinz, Michael R., Hirsch, Michael, Hitcho, Robert S., Hodapp, Klaus, Hodge, Philip E., Hoffman, Melissa, Holfeltz, Sherie T., Holler, Bryan Jason, Hoppa, Jennifer Rose, Horner, Scott, Howard, Joseph M., Howard, Richard J., Huber, Jean M., Hunkeler, Joseph S., Hunter, Alexander, Hunter, David Gavin, Hurd, Spencer W., Hurst, Brendan J., Hutchings, John B., Hylan, Jason E., Ignat, Luminita Ilinca, Illingworth, Garth, Irish, Sandra M., Isaacs III, John C., Jackson Jr., Wallace C., Jaffe, Daniel T., Jahic, Jasmin, Jahromi, Amir, Jakobsen, Peter, James, Bryan, James, John C., James, LeAndrea Rae, Jamieson, William Brian, Jandra, Raymond D., Jayawardhana, Ray, Jedrzejewski, Robert, Jeffers, Basil S., Jensen, Peter, Joanne, Egges, Johns, Alan T., Johnson, Carl A., Johnson, Eric L., Johnson, Patricia, Johnson, Phillip Stephen, Johnson, Thomas K., Johnson, Timothy W., Johnstone, Doug, Jollet, Delphine, Jones, Danny P., Jones, Gregory S., Jones, Olivia C., Jones, Ronald A., Jones, Vicki, Jordan, Ian J., Jordan, Margaret E., Jue, Reginald, Jurkowski, Mark H., Justis, Grant, Justtanont, Kay, Kaleida, Catherine C., Kalirai, Jason S., Kalmanson, Phillip Cabrales, Kaltenegger, Lisa, Kammerer, Jens, Kan, Samuel K., Kanarek, Graham Childs, Kao, Shaw-Hong, Karakla, Diane M., Karl, Hermann, Kassin, Susan A., Kauffman, David D., Kavanagh, Patrick, Kelley, Leigh L., Kelly, Douglas M., Kendrew, Sarah, Kennedy, Herbert V., Kenny, Deborah A., Keski-Kuha, Ritva A., Keyes, Charles D., Khan, Ali, Kidwell, Richard C., Kimble, Randy A., King, James S., King, Richard C., Kinzel, Wayne M., Kirk, Jeffrey R., Kirkpatrick, Marc E., Klaassen, Pamela, Klingemann, Lana, Klintworth, Paul U., Knapp, Bryan Adam, Knight, Scott, Knollenberg, Perry J., Knutsen, Daniel Mark, Koehler, Robert, Koekemoer, Anton M., Kofler, Earl T., Kontson, Vicki L., Kovacs, Aiden Rose, Kozhurina-Platais, Vera, Krause, Oliver, Kriss, Gerard A., Krist, John, Kristoffersen, Monica R., Krogel, Claudia, Krueger, Anthony P., Kulp, Bernard A., Kumari, Nimisha, Kwan, Sandy W., Kyprianou, Mark, Labador, Aurora Gadiano, Labiano, Álvaro, Lafrenière, David, Lagage, Pierre-Olivier, Laidler, Victoria G., Laine, Benoit, Laird, Simon, Lajoie, Charles-Philippe, Lallo, Matthew D., Lam, May Yen, LaMassa, Stephanie Marie, Lambros, Scott D., Lampenfield, Richard Joseph, Lander, Matthew Ed, Langston, James Hutton, Larson, Kirsten, Larson, Melora, LaVerghetta, Robert Joseph, Law, David R., Lawrence, Jon F., Lee, David W., Lee, Janice, Lee, Yat-Ning Paul, Leisenring, Jarron, Leveille, Michael Dunlap, Levenson, Nancy A., Levi, Joshua S., Levine, Marie B., Lewis, Dan, Lewis, Jake, Lewis, Nikole, Libralato, Mattia, Lidon, Norbert, Liebrecht, Paula Louisa, Lightsey, Paul, Lilly, Simon, Lim, Frederick C., Lim, Pey Lian, Ling, Sai-Kwong, Link, Lisa J., Link, Miranda Nicole, Lipinski, Jamie L., Liu, XiaoLi, Lo, Amy S., Lobmeyer, Lynette, Logue, Ryan M., Long, Chris A., Long, Douglas R., Long, Ilana D., Long, Knox S., López-Caniego, Marcos, Lotz, Jennifer M., Love-Pruitt, Jennifer M., Lubskiy, Michael, Luers, Edward B., Luetgens, Robert A., Luevano, Annetta J., Lui, Sarah Marie G. Flores, Lund III, James M., Lundquist, Ray A., Lunine, Jonathan, Lützgendorf, Nora, Lynch, Richard J., MacDonald, Alex J., MacDonald, Kenneth, Macias, Matthew J., Macklis, Keith I., Maghami, Peiman, Maharaja, Rishabh Y., Maiolino, Roberto, Makrygiannis, Konstantinos G., Malla, Sunita Giri, Malumuth, Eliot M., Manjavacas, Elena, Marini, Andrea, Marrione, Amanda, Marston, Anthony, Martel, André R, Martin, Didier, Martin, Peter G., Martinez, Kristin L., Maschmann, Marc, Masci, Gregory L., Masetti, Margaret E., Maszkiewicz, Michael, Matthews, Gary, Matuskey, Jacob E., McBrayer, Glen A., McCarthy, Donald W., McCaughrean, Mark J., McClare, Leslie A., McClare, Michael D., McCloskey, John C., McClurg, Taylore D., McCoy, Martin, McElwain, Michael W., McGregor, Roy D., McGuffey, Douglas B., McKay, Andrew G., McKenzie, William K., McLean, Brian, McMaster, Matthew, McNeil, Warren, De Meester, Wim, Mehalick, Kimberly L., Meixner, Margaret, Meléndez, Marcio, Menzel, Michael P., Menzel, Michael T., Merz, Matthew, Mesterharm, David D., Meyer, Michael R., Meyett, Michele L., Meza, Luis E., Midwinter, Calvin, Milam, Stefanie N., Miller, Jay Todd, Miller, William C., Miskey, Cherie L., Misselt, Karl, Mitchell, Eileen P., Mohan, Martin, Montoya, Emily E., Moran, Michael J., Morishita, Takahiro, Moro-Martín, Amaya, Morrison, Debra L., Morrison, Jane, Morse, Ernie C., Moschos, Michael, Moseley, S. H., Mosier, Gary E., Mosner, Peter, Mountain, Matt, Muckenthaler, Jason S., Mueller, Donald G., Mueller, Migo, Muhiem, Daniella, Mühlmann, Prisca, Mullally, Susan Elizabeth, Mullen, Stephanie M., Munger, Alan J, Murphy, Jess, Murray, Katherine T., Muzerolle, James C., Mycroft, Matthew, Myers, Andrew, Myers, Carey R., Myers, Fred Richard R., Myers, Richard, Myrick, Kaila, Nagle IV, Adrian F., Nayak, Omnarayani, Naylor, Bret, Neff, Susan G., Nelan, Edmund P., Nella, John, Nguyen, Duy Tuong, Nguyen, Michael N., Nickson, Bryony, Nidhiry, John Joseph, Niedner, Malcolm B., Nieto-Santisteban, Maria, Nikolov, Nikolay K., Nishisaka, Mary Ann, Nota, Antonella, O'Mara, Robyn C., Oboryshko, Michael, O'Brien, Marcus B., Ochs, William R., Offenberg, Joel D., Ogle, Patrick Michael, Ohl, Raymond G., Olmsted, Joseph Hamden, Osborne, Shannon Barbara, O'Shaughnessy, Brian Patrick, Östlin, Göran, O'Sullivan, Brian, Otor, O. Justin, Ottens, Richard, Ouellette, Nathalie N. -Q., Outlaw, Daria J., Owens, Beverly A., Pacifici, Camilla, Page, James Christophe, Paranilam, James G., Park, Sang, Parrish, Keith A., Paschal, Laura, Patapis, Polychronis, Patel, Jignasha, Patrick, Keith, Pattishall Jr., Robert A., Paul, Douglas William, Paul, Shirley J., Pauly, Tyler Andrew, Pavlovsky, Cheryl M., Peña-Guerrero, Maria, Pedder, Andrew H., Peek, Matthew Weldon, Pelham, Patricia A., Penanen, Konstantin, Perriello, Beth A., Perrin, Marshall D., Perrine, Richard F., Perrygo, Chuck, Peslier, Muriel, Petach, Michael, Peterson, Karla A., Pfarr, Tom, Pierson, James M., Pietraszkiewicz, Martin, Pilchen, Guy, Pipher, Judy L., Pirzkal, Norbert, Pitman, Joseph T., Player, Danielle M., Plesha, Rachel, Plitzke, Anja, Pohner, John A., Poletis, Karyn Konstantin, Pollizzi, Joseph A., Polster, Ethan, Pontius, James T., Pontoppidan, Klaus, Porges, Susana C., Potter, Gregg D., Prescott, Stephen, Proffitt, Charles R., Pueyo, Laurent, Neira, Irma Aracely Quispe, Radich, Armando, Rager, Reiko T., Rameau, Julien, Ramey, Deborah D., Alarcon, Rafael Ramos, Rampini, Riccardo, Rapp, Robert, Rashford, Robert A., Rauscher, Bernard J., Ravindranath, Swara, Rawle, Timothy, Rawlings, Tynika N., Ray, Tom, Regan, Michael W., Rehm, Brian, Rehm, Kenneth D., Reid, Neill, Reis, Carl A., Renk, Florian, Reoch, Tom B., Ressler, Michael, Rest, Armin W., Reynolds, Paul J., Richon, Joel G., Richon, Karen V., Ridgaway, Michael, Riedel, Adric Richard, Rieke, George H., Rieke, Marcia, Rifelli, Richard E., Rigby, Jane R., Riggs, Catherine S., Ringel, Nancy J., Ritchie, Christine E., Rix, Hans-Walter, Robberto, Massimo, Robinson, Michael S., Robinson, Orion, Rock, Frank W., Rodriguez, David R., del Pino, Bruno Rodríguez, Roellig, Thomas, Rohrbach, Scott O., Roman, Anthony J., Romelfanger, Frederick J., Romo Jr., Felipe P., Rosales, Jose J., Rose, Perry, Roteliuk, Anthony F., Roth, Marc N., Rothwell, Braden Quinn, Rouzaud, Sylvain, Rowe, Jason, Rowlands, Neil, Roy, Arpita, Royer, Pierre, Rui, Chunlei, Rumler, Peter, Rumpl, William, Russ, Melissa L., Ryan, Michael B., Ryan, Richard M., Saad, Karl, Sabata, Modhumita, Sabatino, Rick, Sabbi, Elena, Sabelhaus, Phillip A., Sabia, Stephen, Sahu, Kailash C., Saif, Babak N., Salvignol, Jean-Christophe, Samara-Ratna, Piyal, Samuelson, Bridget S., Sanders, Felicia A., Sappington, Bradley, Sargent, B. A., Sauer, Arne, Savadkin, Bruce J., Sawicki, Marcin, Schappell, Tina M., Scheffer, Caroline, Scheithauer, Silvia, Scherer, Ron, Schiff, Conrad, Schlawin, Everett, Schmeitzky, Olivier, Schmitz, Tyler S., Schmude, Donald J., Schneider, Analyn, Schreiber, Jürgen, Schroeven-Deceuninck, Hilde, Schultz, John J., Schwab, Ryan, Schwartz, Curtis H., Scoccimarro, Dario, Scott, John F., Scott, Michelle B., Seaton, Bonita L., Seely, Bruce S., Seery, Bernard, Seidleck, Mark, Sembach, Kenneth, Shanahan, Clare Elizabeth, Shaughnessy, Bryan, Shaw, Richard A., Shay, Christopher Michael, Sheehan, Even, Sheth, Kartik, Shih, Hsin-Yi, Shivaei, Irene, Siegel, Noah, Sienkiewicz, Matthew G., Simmons, Debra D., Simon, Bernard P., Sirianni, Marco, Sivaramakrishnan, Anand, Slade, Jeffrey E., Sloan, G. C., Slocum, Christine E., Slowinski, Steven E., Smith, Corbett T., Smith, Eric P., Smith, Erin C., Smith, Koby, Smith, Robert, Smith, Stephanie J., Smolik, John L., Soderblom, David R., Sohn, Sangmo Tony, Sokol, Jeff, Sonneborn, George, Sontag, Christopher D., Sooy, Peter R., Soummer, Remi, Southwood, Dana M., Spain, Kay, Sparmo, Joseph, Speer, David T., Spencer, Richard, Sprofera, Joseph D., Stallcup, Scott S., Stanley, Marcia K., Stansberry, John A., Stark, Christopher C., Starr, Carl W., Stassi, Diane Y., Steck, Jane A., Steeley, Christine D., Stephens, Matthew A., Stephenson, Ralph J., Stewart, Alphonso C., Stiavelli, Massimo, Stockman Jr., Hervey, Strada, Paolo, Straughn, Amber N., Streetman, Scott, Strickland, David Kendal, Strobele, Jingping F., Stuhlinger, Martin, Stys, Jeffrey Edward, Such, Miguel, Sukhatme, Kalyani, Sullivan, Joseph F., Sullivan, Pamela C., Sumner, Sandra M., Sun, Fengwu, Sunnquist, Benjamin Dale, Swade, Daryl Allen, Swam, Michael S., Swenton, Diane F., Swoish, Robby A., Litten, Oi In Tam, Tamas, Laszlo, Tao, Andrew, Taylor, David K., Taylor, Joanna M., Plate, Maurice te, Van Tea, Mason, Teague, Kelly K., Telfer, Randal C., Temim, Tea, Texter, Scott C., Thatte, Deepashri G., Thompson, Christopher Lee, Thompson, Linda M., Thomson, Shaun R., Thronson, Harley, Tierney, C. M., Tikkanen, Tuomo, Tinnin, Lee, Tippet, William Thomas, Todd, Connor William, Tran, Hien D., Trauger, John, Trejo, Edwin Gregorio, Truong, Justin Hoang Vinh, Tsukamoto, Christine L., Tufail, Yasir, Tumlinson, Jason, Tustain, Samuel, Tyra, Harrison, Ubeda, Leonardo, Underwood, Kelli, Uzzo, Michael A., Vaclavik, Steven, Valenduc, Frida, Valenti, Jeff A., Van Campen, Julie, van de Wetering, Inge, Van Der Marel, Roeland P., van Haarlem, Remy, Vandenbussche, Bart, Vanterpool, Dona D., Vernoy, Michael R., Costas, Maria Begoña Vila, Volk, Kevin, Voorzaat, Piet, Voyton, Mark F., Vydra, Ekaterina, Waddy, Darryl J., Waelkens, Christoffel, Wahlgren, Glenn Michael, Walker Jr., Frederick E., Wander, Michel, Warfield, Christine K., Warner, Gerald, Wasiak, Francis C., Wasiak, Matthew F., Wehner, James, Weiler, Kevin R., Weilert, Mark, Weiss, Stanley B., Wells, Martyn, Welty, Alan D., Wheate, Lauren, Wheeler, Thomas P., White, Christy L., Whitehouse, Paul, Whiteleather, Jennifer Margaret, Whitman, William Russell, Williams, Christina C., Willmer, Christopher N. A., Willott, Chris J., Willoughby, Scott P., Wilson, Andrew, Wilson, Debra, Wilson, Donna V., Windhorst, Rogier, Wislowski, Emily Christine, Wolfe, David J., Wolfe, Michael A., Wolff, Schuyler, Wondel, Amancio, Woo, Cindy, Woods, Robert T., Worden, Elaine, Workman, William, Wright, Gillian S., Wu, Carl, Wu, Chi-Rai, Wun, Dakin D., Wymer, Kristen B., Yadetie, Thomas, Yan, Isabelle C., Yang, Keith C., Yates, Kayla L., Yeager, Christopher R., Yerger, Ethan John, Young, Erick T., Young, Gary, Yu, Gene, Yu, Susan, Zak, Dean S., Zeidler, Peter, Zepp, Robert, Zhou, Julia, Zincke, Christian A., Zonak, Stephanie, and Zondag, Elisabeth

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit., Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figures

Published
2023
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28. Framework for engineering of spin defects in hexagonal boron nitride by focused ion beams

Author

Hennessey, Madeline, Whitefield, Benjamin, Gale, Angus, Scott, John A, Kianinia, Mehran, Aharonovich, Igor, and Toth, Milos

Subjects
Condensed Matter - Materials Science
Abstract

Hexagonal boron nitride (hBN) is gaining interest as a wide bandgap van der Waals host of optically active spin defects for quantum technologies. Most studies of the spin-photon interface in hBN focus on the negatively charged boron vacancy (VB-) defect, which is typically fabricated by ion irradiation. However, VB- fabrication methods often lack robustness and reproducibility when applied to thin flakes (less than 10 nm) of hBN. Here we identify mechanisms that both promote and inhibit VB- generation and optimize ion beam parameters for site-specific fabrication of optically active VB- centers. We emphasize conditions accessible by high resolution focused ion beam (FIB) systems, and present a framework for VB- fabrication in hBN flakes of arbitrary thickness for applications in quantum sensing and quantum information processing., Comment: 11 pages, 5 figures

Published
2023

29. Cardiac function is regulated by the sodium-dependent inhibition of the sodium-calcium exchanger NCX1

Author

Kyle Scranton, Scott John, Marina Angelini, Federica Steccanella, Soban Umar, Rui Zhang, Joshua I. Goldhaber, Riccardo Olcese, and Michela Ottolia

Subjects
Science
Abstract

Abstract The Na+-Ca2+ exchanger (NCX1) is the dominant Ca2+ extrusion mechanism in cardiac myocytes. NCX1 activity is inhibited by intracellular Na+ via a process known as Na+-dependent inactivation. A central question is whether this inactivation plays a physiological role in heart function. Using CRISPR/Cas9, we inserted the K229Q mutation in the gene (Slc8a1) encoding for NCX1. This mutation removes the Na+-dependent inactivation while preserving transport properties and other allosteric regulations. NCX1 mRNA levels, protein expression, and protein localization are unchanged in K229Q male mice. However, they exhibit reduced left ventricular ejection fraction and fractional shortening, while displaying a prolonged QT interval. K229Q ventricular myocytes show enhanced NCX1 activity, resulting in action potential prolongation, higher incidence of aberrant action potentials, a faster decline of Ca2+ transients, and depressed cell shortening. The results demonstrate that NCX1 Na+-dependent inactivation plays an essential role in heart function by affecting both cardiac excitability and contractility.

Published
2024
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31. BOARD BOOKS ROUNDUP

Author

Scott, John

Subjects
Education, Library and information science, Publishing industry
Abstract

These days, young children engage with so many different types of devices and e-toys that it can be hard for books to compete for their attention, but this collection of [...]

Published
2024

33. Timing constraints due to real-time graph traversal algorithms on incomplete cluster states in photonic measurement-based quantum computing

Author

Scott, John R. and Balram, Krishna C.

Subjects
Quantum Physics, Physics - Applied Physics, Physics - Optics
Abstract

Understanding the computational overheads imposed by classical control systems on quantum computing platforms becomes critically important as these quantum machines grow in scale and complexity. In this work, we calculate the overheads imposed by the implementation of real-time graph traversal algorithms needed to find computational paths through incomplete cluster states for the implementation of one-qubit gates; a necessary requirement for a realistic implementation of photonic measurement-based quantum computing. By implementing two different algorithms, a global breadth-first search that searches the entire cluster state and an incremental version that traverses a narrow sub-section of the cluster state, we analyze the tradeoff between the accuracy of finding viable paths and the speed at which this operation can be performed, which constrains the overall photonic clock cycle of the system. We also outline the broader implications of our results for implementing classical control systems for measurement-based photonic quantum computing., Comment: 18 pages, 14 figures. Comments welcome !!!

Published
2022
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38. The Science Performance of JWST as Characterized in Commissioning

Author

Rigby, Jane, Perrin, Marshall, McElwain, Michael, Kimble, Randy, Friedman, Scott, Lallo, Matt, Doyon, René, Feinberg, Lee, Ferruit, Pierre, Glasse, Alistair, Rieke, Marcia, Rieke, George, Wright, Gillian, Willott, Chris, Colon, Knicole, Milam, Stefanie, Neff, Susan, Stark, Christopher, Valenti, Jeff, Abell, Jim, Abney, Faith, Abul-Huda, Yasin, Acton, D. Scott, Adams, Evan, Adler, David, Aguilar, Jonathan, Ahmed, Nasif, Albert, Loïc, Alberts, Stacey, Aldridge, David, Allen, Marsha, Altenburg, Martin, Marquez, Javier Alvarez, de Oliveira, Catarina Alves, Andersen, Greg, Anderson, Harry, Anderson, Sara, Argyriou, Ioannis, Armstrong, Amber, Arribas, Santiago, Artigau, Etienne, Arvai, Amanda, Atkinson, Charles, Bacon, Gregory, Bair, Thomas, Banks, Kimberly, Barrientes, Jaclyn, Barringer, Bruce, Bartosik, Peter, Bast, William, Baudoz, Pierre, Beatty, Thomas, Bechtold, Katie, Beck, Tracy, Bergeron, Eddie, Bergkoetter, Matthew, Bhatawdekar, Rachana, Birkmann, Stephan, Blazek, Ronald, Blome, Claire, Boccaletti, Anthony, Boeker, Torsten, Boia, John, Bonaventura, Nina, Bond, Nicholas, Bosley, Kari, Boucarut, Ray, Bourque, Matthew, Bouwman, Jeroen, Bower, Gary, Bowers, Charles, Boyer, Martha, Bradley, Larry, Brady, Greg, Braun, Hannah, Breda, David, Bresnahan, Pamela, Bright, Stacey, Britt, Christopher, Bromenschenkel, Asa, Brooks, Brian, Brooks, Keira, Brown, Bob, Brown, Matthew, Brown, Patricia, Bunker, Andy, Burger, Matthew, Bushouse, Howard, Cale, Steven, Cameron, Alex, Cameron, Peter, Canipe, Alicia, Caplinger, James, Caputo, Francis, Cara, Mihai, Carey, Larkin, Carniani, Stefano, Carrasquilla, Maria, Carruthers, Margaret, Case, Michael, Catherine, Riggs, Chance, Don, Chapman, George, Charlot, Stéphane, Charlow, Brian, Chayer, Pierre, Chen, Bin, Cherinka, Brian, Chichester, Sarah, Chilton, Zack, Chonis, Taylor, Clampin, Mark, Clark, Charles, Clark, Kerry, Coe, Dan, Coleman, Benee, Comber, Brian, Comeau, Tom, Connolly, Dennis, Cooper, James, Cooper, Rachel, Coppock, Eric, Correnti, Matteo, Cossou, Christophe, Coulais, Alain, Coyle, Laura, Cracraft, Misty, Curti, Mirko, Cuturic, Steven, Davis, Katherine, Davis, Michael, Dean, Bruce, DeLisa, Amy, deMeester, Wim, Dencheva, Nadia, Dencheva, Nadezhda, DePasquale, Joseph, Deschenes, Jeremy, Detre, Örs Hunor, Diaz, Rosa, Dicken, Dan, DiFelice, Audrey, Dillman, Matthew, Dixon, William, Doggett, Jesse, Donaldson, Tom, Douglas, Rob, DuPrie, Kimberly, Dupuis, Jean, Durning, John, Easmin, Nilufar, Eck, Weston, Edeani, Chinwe, Egami, Eiichi, Ehrenwinkler, Ralf, Eisenhamer, Jonathan, Eisenhower, Michael, Elie, Michelle, Elliott, James, Elliott, Kyle, Ellis, Tracy, Engesser, Michael, Espinoza, Nestor, Etienne, Odessa, Etxaluze, Mireya, Falini, Patrick, Feeney, Matthew, Ferry, Malcolm, Filippazzo, Joseph, Fincham, Brian, Fix, Mees, Flagey, Nicolas, Florian, Michael, Flynn, Jim, Fontanella, Erin, Ford, Terrance, Forshay, Peter, Fox, Ori, Franz, David, Fu, Henry, Fullerton, Alexander, Galkin, Sergey, Galyer, Anthony, Marin, Macarena Garcia, Gardner, Jonathan, Gardner, Lisa, Garland, Dennis, Garrett, Bruce, Gasman, Danny, Gaspar, Andras, Gaudreau, Daniel, Gauthier, Peter, Geers, Vincent, Geithner, Paul, Gennaro, Mario, Giardino, Giovanna, Girard, Julien, Giuliano, Mark, Glassmire, Kirk, Glauser, Adrian, Glazer, Stuart, Godfrey, John, Golimowski, David, Gollnitz, David, Gong, Fan, Gonzaga, Shireen, Gordon, Michael, Gordon, Karl, Goudfrooij, Paul, Greene, Thomas, Greenhouse, Matthew, Grimaldi, Stefano, Groebner, Andrew, Grundy, Timothy, Guillard, Pierre, Gutman, Irvin, Ha, Kong Q., Haderlein, Peter, Hagedorn, Andria, Hainline, Kevin, Haley, Craig, Hami, Maryam, Hamilton, Forrest, Hammel, Heidi, Hansen, Carl, Harkins, Tom, Harr, Michael, Hart, Jessica, Hart, Quyen, Hartig, George, Hashimoto, Ryan, Haskins, Sujee, Hathaway, William, Havey, Keith, Hayden, Brian, Hecht, Karen, Heller-Boyer, Chris, Henriques, Caroline, Henry, Alaina, Hermann, Karl, Hernandez, Scarlin, Hesman, Brigette, Hicks, Brian, Hilbert, Bryan, Hines, Dean, Hoffman, Melissa, Holfeltz, Sherie, Holler, Bryan J., Hoppa, Jennifer, Hott, Kyle, Howard, Joseph, Howard, Rick, Hunter, Alexander, Hunter, David, Hurst, Brendan, Husemann, Bernd, Hustak, Leah, Ignat, Luminita Ilinca, Illingworth, Garth, Irish, Sandra, Jackson, Wallace, Jahromi, Amir, Jakobsen, Peter, James, LeAndrea, James, Bryan, Januszewski, William, Jenkins, Ann, Jirdeh, Hussein, Johnson, Phillip, Johnson, Timothy, Jones, Vicki, Jones, Ron, Jones, Danny, Jones, Olivia, Jordan, Ian, Jordan, Margaret, Jurczyk, Sarah, Jurling, Alden, Kaleida, Catherine, Kalmanson, Phillip, Kammerer, Jens, Kang, Huijo, Kao, Shaw-Hong, Karakla, Diane, Kavanagh, Patrick, Kelly, Doug, Kendrew, Sarah, Kennedy, Herbert, Kenny, Deborah, Keski-kuha, Ritva, Keyes, Charles, Kidwell, Richard, Kinzel, Wayne, Kirk, Jeff, Kirkpatrick, Mark, Kirshenblat, Danielle, Klaassen, Pamela, Knapp, Bryan, Knight, J. Scott, Knollenberg, Perry, Koehler, Robert, Koekemoer, Anton, Kovacs, Aiden, Kulp, Trey, Kumari, Nimisha, Kyprianou, Mark, La Massa, Stephanie, Labador, Aurora, Ortega, Alvaro Labiano, Lagage, Pierre-Olivier, Lajoie, Charles-Phillipe, Lallo, Matthew, Lam, May, Lamb, Tracy, Lambros, Scott, Lampenfield, Richard, Langston, James, Larson, Kirsten, Law, David, Lawrence, Jon, Lee, David, Leisenring, Jarron, Lepo, Kelly, Leveille, Michael, Levenson, Nancy, Levine, Marie, Levy, Zena, Lewis, Dan, Lewis, Hannah, Libralato, Mattia, Lightsey, Paul, Link, Miranda, Liu, Lily, Lo, Amy, Lockwood, Alexandra, Logue, Ryan, Long, Chris, Long, Douglas, Loomis, Charles, Lopez-Caniego, Marcos, Alvarez, Jose Lorenzo, Love-Pruitt, Jennifer, Lucy, Adrian, Luetzgendorf, Nora, Maghami, Peiman, Maiolino, Roberto, Major, Melissa, Malla, Sunita, Malumuth, Eliot, Manjavacas, Elena, Mannfolk, Crystal, Marrione, Amanda, Marston, Anthony, Martel, André, Maschmann, Marc, Masci, Gregory, Masciarelli, Michaela, Maszkiewicz, Michael, Mather, John, McKenzie, Kenny, McLean, Brian, McMaster, Matthew, Melbourne, Katie, Meléndez, Marcio, Menzel, Michael, Merz, Kaiya, Meyett, Michele, Meza, Luis, Miskey, Cherie, Misselt, Karl, Moller, Christopher, Morrison, Jane, Morse, Ernie, Moseley, Harvey, Mosier, Gary, Mountain, Matt, Mueckay, Julio, Mueller, Michael, Mullally, Susan, Murphy, Jess, Murray, Katherine, Murray, Claire, Mustelier, David, Muzerolle, James, Mycroft, Matthew, Myers, Richard, Myrick, Kaila, Nanavati, Shashvat, Nance, Elizabeth, Nayak, Omnarayani, Naylor, Bret, Nelan, Edmund, Nickson, Bryony, Nielson, Alethea, Nieto-Santisteban, Maria, Nikolov, Nikolay, Noriega-Crespo, Alberto, O'Shaughnessy, Brian, O'Sullivan, Brian, Ochs, William, Ogle, Patrick, Oleszczuk, Brenda, Olmsted, Joseph, Osborne, Shannon, Ottens, Richard, Owens, Beverly, Pacifici, Camilla, Pagan, Alyssa, Page, James, Park, Sang, Parrish, Keith, Patapis, Polychronis, Paul, Lee, Pauly, Tyler, Pavlovsky, Cheryl, Pedder, Andrew, Peek, Matthew, Pena-Guerrero, Maria, Pennanen, Konstantin, Perez, Yesenia, Perna, Michele, Perriello, Beth, Phillips, Kevin, Pietraszkiewicz, Martin, Pinaud, Jean-Paul, Pirzkal, Norbert, Pitman, Joseph, Piwowar, Aidan, Platais, Vera, Player, Danielle, Plesha, Rachel, Pollizi, Joe, Polster, Ethan, Pontoppidan, Klaus, Porterfield, Blair, Proffitt, Charles, Pueyo, Laurent, Pulliam, Christine, Quirt, Brian, Neira, Irma Quispe, Alarcon, Rafael Ramos, Ramsay, Leah, Rapp, Greg, Rapp, Robert, Rauscher, Bernard, Ravindranath, Swara, Rawle, Timothy, Regan, Michael, Reichard, Timothy A., Reis, Carl, Ressler, Michael E., Rest, Armin, Reynolds, Paul, Rhue, Timothy, Richon, Karen, Rickman, Emily, Ridgaway, Michael, Ritchie, Christine, Rix, Hans-Walter, Robberto, Massimo, Robinson, Gregory, Robinson, Michael, Robinson, Orion, Rock, Frank, Rodriguez, David, Del Pino, Bruno Rodriguez, Roellig, Thomas, Rohrbach, Scott, Roman, Anthony, Romelfanger, Fred, Rose, Perry, Roteliuk, Anthony, Roth, Marc, Rothwell, Braden, Rowlands, Neil, Roy, Arpita, Royer, Pierre, Royle, Patricia, Rui, Chunlei, Rumler, Peter, Runnels, Joel, Russ, Melissa, Rustamkulov, Zafar, Ryden, Grant, Ryer, Holly, Sabata, Modhumita, Sabatke, Derek, Sabbi, Elena, Samuelson, Bridget, Sapp, Benjamin, Sappington, Bradley, Sargent, B., Sauer, Arne, Scheithauer, Silvia, Schlawin, Everett, Schlitz, Joseph, Schmitz, Tyler, Schneider, Analyn, Schreiber, Jürgen, Schulze, Vonessa, Schwab, Ryan, Scott, John, Sembach, Kenneth, Shanahan, Clare, Shaughnessy, Bryan, Shaw, Richard, Shawger, Nanci, Shay, Christopher, Sheehan, Evan, Shen, Sharon, Sherman, Allan, Shiao, Bernard, Shih, Hsin-Yi, Shivaei, Irene, Sienkiewicz, Matthew, Sing, David, Sirianni, Marco, Sivaramakrishnan, Anand, Skipper, Joy, Sloan, Gregory, Slocum, Christine, Slowinski, Steven, Smith, Erin, Smith, Eric, Smith, Denise, Smith, Corbett, Snyder, Gregory, Soh, Warren, Sohn, Tony, Soto, Christian, Spencer, Richard, Stallcup, Scott, Stansberry, John, Starr, Carl, Starr, Elysia, Stewart, Alphonso, Stiavelli, Massimo, Straughn, Amber, Strickland, David, Stys, Jeff, Summers, Francis, Sun, Fengwu, Sunnquist, Ben, Swade, Daryl, Swam, Michael, Swaters, Robert, Swoish, Robby, Taylor, Joanna M., Taylor, Rolanda, Plate, Maurice Te, Tea, Mason, Teague, Kelly, Telfer, Randal, Temim, Tea, Thatte, Deepashri, Thompson, Christopher, Thompson, Linda, Thomson, Shaun, Tikkanen, Tuomo, Tippet, William, Todd, Connor, Toolan, Sharon, Tran, Hien, Trejo, Edwin, Truong, Justin, Tsukamoto, Chris, Tustain, Samuel, Tyra, Harrison, Ubeda, Leonardo, Underwood, Kelli, Uzzo, Michael, Van Campen, Julie, Vandal, Thomas, Vandenbussche, Bart, Vila, Begoña, Volk, Kevin, Wahlgren, Glenn, Waldman, Mark, Walker, Chanda, Wander, Michel, Warfield, Christine, Warner, Gerald, Wasiak, Matthew, Watkins, Mitchell, Weaver, Andrew, Weilert, Mark, Weiser, Nick, Weiss, Ben, Weissman, Sarah, Welty, Alan, West, Garrett, Wheate, Lauren, Wheatley, Elizabeth, Wheeler, Thomas, White, Rick, Whiteaker, Kevin, Whitehouse, Paul, Whiteleather, Jennifer, Whitman, William, Williams, Christina, Willmer, Christopher, Willoughby, Scott, Wilson, Andrew, Wirth, Gregory, Wislowski, Emily, Wolf, Erin, Wolfe, David, Wolff, Schuyler, Workman, Bill, Wright, Ray, Wu, Carl, Wu, Rai, Wymer, Kristen, Yates, Kayla, Yeager, Christopher, Yeates, Jared, Yerger, Ethan, Yoon, Jinmi, Young, Alice, Yu, Susan, Zak, Dean, Zeidler, Peter, Zhou, Julia, Zielinski, Thomas, Zincke, Cristian, and Zonak, Stephanie

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

This paper characterizes the actual science performance of the James Webb Space Telescope (JWST), as determined from the six month commissioning period. We summarize the performance of the spacecraft, telescope, science instruments, and ground system, with an emphasis on differences from pre-launch expectations. Commissioning has made clear that JWST is fully capable of achieving the discoveries for which it was built. Moreover, almost across the board, the science performance of JWST is better than expected; in most cases, JWST will go deeper faster than expected. The telescope and instrument suite have demonstrated the sensitivity, stability, image quality, and spectral range that are necessary to transform our understanding of the cosmos through observations spanning from near-earth asteroids to the most distant galaxies., Comment: 5th version as accepted to PASP; 31 pages, 18 figures; https://iopscience.iop.org/article/10.1088/1538-3873/acb293

Published
2022
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39. Nanoscale 3D tomography by in-flight fluorescence spectroscopy of atoms sputtered by a focused ion beam

Author

Budnik, Garrett, Scott, John, Jiao, Chengge, Maazouz, Mostafa, Gledhill, Galen, Fu, Lan, Tan, Hark Hoe, and Toth, Milos

Subjects
Physics - Applied Physics, Physics - Instrumentation and Detectors
Abstract

Nanoscale fabrication and characterisation techniques critically underpin a vast range of fields, including materials science, nanoelectronics and nanobiotechnology. Focused ion beam (FIB) techniques are particularly appealing due to their high spatial resolution and widespread use for processing of nanostructured materials and devices. Here, we introduce FIB-induced fluorescence spectroscopy (FIB-FS) as a nanoscale technique for spectroscopic detection of atoms sputtered by an ion beam. We use semiconductor heterostructures to demonstrate nanoscale lateral and depth resolution and show that it is limited by ion-induced intermixing of nanostructured materials. Sensitivity is demonstrated qualitatively by depth-profiling of 3.5, 5 and 8 nm quantum wells, and quantitatively by detection of trace-level impurities present at parts-per-million levels. To showcase the utility of the FIB-FS technique, we use it to characterise quantum wells and Li-ion batteries. Our work introduces FIB-FS as a high-resolution, high sensitivity, 3D analysis and tomography technique that combines the versatility of FIB nanofabrication techniques with the power of diffraction-unlimited fluorescence spectroscopy. It is applicable to all elements in the periodic table, and enables real-time analysis during direct-write nanofabrication by focused ion beams.

Published
2022
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40. Suppression of surface roughening during ion bombardment of semiconductors

Author

Scott, John A., Bishop, James, and Toth, Milos

Subjects
Condensed Matter - Materials Science, Physics - Applied Physics
Abstract

Ion beams are used routinely for processing of semiconductors, particularly sputtering, ion implantation and direct-write fabrication of nanostructures. However, the utility of ion beam techniques is limited by crystal damage and surface roughening. Damage can be reduced or eliminated by performing irradiation at elevated temperatures. However, at these conditions, surface roughening is highly problematic due to thermal mobility of adatoms and surface vacancies. Here we solve this problem using hydrogen gas, which we use to stabilize surface mass flow and suppress roughening during ion bombardment of elemental and compound semiconductors. We achieve smooth surfaces during ion-beam processing, and show that the method can be enhanced by radicalizing H2 gas using a remote plasma source. Our approach is broadly applicable, and expands the utility of ion beam techniques for the processing and fabrication of functional materials and nanostructures., Comment: 14 pages, 5 figures

Published
2022

41. Coupling Spin Defects in Hexagonal Boron Nitride to Titanium Oxide Ring Resonators

Author

Nonahal, Milad, Li, Chi, Tjiptoharsono, Febiana, Ding, Lu, Stewart, Connor, Scott, John, Toth, Milos, Ha, Son Tung, Kianinia, Mehran, and Aharonovich, Igor

Subjects
Physics - Optics
Abstract

Spin-dependent optical transitions are attractive for a plethora of applications in quantum technologies. Here we report on utilization of high quality ring resonators fabricated from TiO2 to enhance the emission from negatively charged boron vacancies in hexagonal Boron Nitride. We show that the emission from these defects can efficiently couple into the whispering gallery modes of the ring resonators. Optically coupled boron vacancy showed photoluminescence contrast in optically detected magnetic resonance signals from the hybrid coupled devices. Our results demonstrate a practical method for integration of spin defects in 2D materials with dielectric resonators which is a promising platform for quantum technologies.

Published
2022

42. Virtual Care and Mental Health: Dismantling Silos to Strengthen Care Delivery.

Author

Scott, John, Chen, Christopher, Yellowlees, Peter, and Becker, Daniel

Subjects
behavioral health, tele psychiatry, virtual care
Abstract

BACKGROUND: During the COVID-19 pandemic, many Americans experienced new or worsened mental health conditions. Concurrently, much care switched from in-person to virtual care, highlighting the value of virtual care but also some of the underlying challenges. METHODS: This paper explores one such challenge, the separation of mental health care from physical health care, and a potential solution, collaborative care. It is a team-based approach linking psychiatrists to primary care providers that can help break down the silos of care created through reimbursement models. RESULTS: In this context of collaborative care, high quality virtual care further bridges the divide between physical and mental health care. Asynchronous virtual care for mental and behavioral health is an innovation that can create efficiencies while still supporting collaborative care. DISCUSSION: The barriers and weaknesses of using virtual care exclusively for mental and behavioral health are discussed, as well as examples of policy changes which can improve mental health care through collaborative virtual care.

Published
2023

44. Quantum interference of resonance fluorescence from Germanium-vacancy color centers in diamond

Author

Chen, Disheng, Froech, Johannes, Ru, Shihao, Cai, Hongbing, Wang, Naizhou, Adamo, Giorgio, Scott, John, Li, Fuli, Zheludev, Nikolay, Aharonovich, Igor, and Gao, Wei-bo

Subjects
Quantum Physics, Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

Resonance fluorescence from a quantum emitter is an ideal source to extract indistinguishable photons. By using the cross polarization to suppress the laser scattering, we observed resonance fluorescence from GeV color centers in diamond at cryogenic temperature. The Fourier-transform-limited linewidth emission with $T_2/2T_1\sim0.86$ allows for two-photon interference based on single GeV color center. Under pulsed excitation, the 24 ns separated photons exhibit a Hong-Ou-Mandel visibility of $0.604\pm0.022$, while the continuous-wave excitation leads to a coalescence time window of 1.05 radiative lifetime. Together with single-shot readout of spin states, it paves the way towards building a quantum network with GeV color centers in diamond., Comment: 5 pages, 4 figures; Supplements 9 pages, 8 figures

Published
2022
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46. Timing constraints imposed by classical digital control systems on photonic implementations of measurement-based quantum computing

Author

Scott, John R. and Balram, Krishna C.

Subjects
Quantum Physics, Computer Science - Emerging Technologies, Physics - Applied Physics, Physics - Optics
Abstract

Most of the architectural research on photonic implementations of measurement-based quantum computing (MBQC) has focused on the quantum resources involved in the problem with the implicit assumption that these will provide the main constraints on system scaling. However, the `flying-qubit' architecture of photonic MBQC requires specific timing constraints that need to be met by the classical control system. This classical control includes, for example: the amplification of the signals from single-photon detectors to voltage levels compatible with digital systems; the implementation of a control system which converts measurement outcomes into basis settings for measuring subsequent cluster qubits, in accordance with the quantum algorithm being implemented; and the digital-to-analog converter (DAC) and amplifier systems required to set these measurement bases using a fast phase modulator. In this paper, we analyze the digital system needed to implement arbitrary one-qubit rotations and controlled-NOT (CNOT) gates in discrete-variable photonic MBQC, in the presence of an ideal cluster state generator, with the main aim of understanding the timing constraints imposed by the digital logic on the analog system and quantum hardware. We use static timing analysis of a Xilinx FPGA (7 series) to provide a practical upper bound on the speed at which the adaptive measurement processing can be performed, in turn constraining the photonic clock rate of the system. Our work points to the importance of co-designing the classical control system in tandem with the quantum system in order to meet the challenging specifications of a photonic quantum computer., Comment: 21 pages, 11 figures. Comments welcome! This work has been submitted to the IEEE for possible publication. Copyright may be transferred without notice, after which this version may no longer be accessible

Published
2021
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47. Coupling Spin Defects in a Layered Material to Nanoscale Plasmonic Cavities

Author

Mendelson, Noah, Ritika, Ritika, Kianinia, Mehran, Scott, John, Kim, Sejeong, Fröch, Johannes E., Gazzana, Camilla, Westerhausen, Mika, Xiao, Licheng, Mohajerani, Seyed Sepehr, Strauf, Stefan, Toth, Milos, Aharonovich, Igor, and Xu, Zai-Quan

Subjects
Physics - Optics
Abstract

Spin defects in hexagonal boron nitride, and specifically the negatively charged boron vacancy (VB) centres, are emerging candidates for quantum sensing. However, the VB defects suffer from low quantum efficiency and as a result exhibit weak photoluminescence. In this work, we demonstrate a scalable approach to dramatically enhance the VB- emission by coupling to a plasmonic gap cavity. The plasmonic cavity is composed of a flat gold surface and a silver cube, with few-layer hBN flakes positioned in between. Employing these plasmonic cavities, we extracted two orders of magnitude in photoluminescence enhancement associated with a corresponding 2 fold enhancement in optically detected magnetic resonance contrast. The work will be pivotal to progress in quantum sensing employing 2D materials, and realisation of nanophotonic devices with spin defects in hexagonal boron nitride.

Published
2021

48. Efficacy of assisted partner services for people who inject drugs in Kenya to identify partners living with HIV and hepatitis C virus infection: a prospective cohort study

Author

Monroe-Wise, Aliza, Mbogo, Loice, Sambai, Betsy, Ludwig-Barron, Natasha, Guthrie, Brandon L, Bukusi, David, Chohan, Bhavna H, Masyuko, Sarah, Scott, John, Juma, Emily, Macharia, Paul, Kingston, Hanley, Sinkele, William, Gitau, Esther, Bosire, Rose, Musyoki, Helgar, Herbeck, Joshua, and Farquhar, Carey

Published
2024
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49. A technology-enabled multi-disciplinary team-based care model for the management of Long COVID and other fatiguing illnesses within a federally qualified health center: protocol for a two-arm, single-blind, pragmatic, quality improvement professional cluster randomized controlled trial

Author

Godino, Job G., Samaniego, Jane C., Sharp, Sydney P., Taren, Douglas, Zuber, Alexandra, Armistad, Amy J., Dezan, Amanda M., Leyba, Azure J., Friedly, Janna L., Bunnell, Aaron E., Matthews, Eva, Miller, Maureen J., Unger, Elizabeth R., Bertolli, Jeanne, Hinckley, Alison, Lin, Jin-Mann S., Scott, John D., Struminger, Bruce B., and Ramers, Christian

Published
2023
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