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BACKGROUND Inflammatory bowel disease (IBD) is associated with complications, frequent hospitalizations, surgery and death. The introduction of biologic drugs into the therapeutic arsenal in the last two decades, combined with an expansion of immunosuppressant therapy, has changed IBD management and may have altered the profile of hospitalizations and in-hospital mortality (IHM) due to IBD. AIM To describe hospitalizations from 2008 to 2018 and to analyze IHM from 1998 to 2017 for IBD in Brazil. METHODS This observational, retrospective, ecological study used secondary data on hospitalizations for IBD in Brazil for 2008-2018 to describe hospitalizations and for 1998-2017 to analyze IHM. Hospitalization data were obtained from the Hospital Information System of the Brazilian Unified Health System and population data from demographic censuses. The following variables were analyzed: Number of deaths and hospitalizations, length of hospital stay, financial costs of hospitalization, sex, age, ethnicity and type of hospital admission. RESULTS There was a reduction in the number of IBD hospitalizations, from 6975 admissions in 1998 to 4113 in 2017 (trend: y = -0.1682x + 342.8; R2 = 0.8197; P < 0.0001). The hospitalization rate also decreased, from 3.60/100000 in 2000 to 2.17 in 2010. IHM rates varied during the 20-year period, between 2.06 in 2017 and 3.64 in 2007, and did not follow a linear trend (y = -0.0005049x + 2.617; R2 = 0,00006; P = 0.9741). IHM rates also varied between regions, increasing in all but the southeast, which showed a decreasing trend (y = -0.1122x + 4.427; R2 = 0,728; P < 0.0001). The Southeast region accounted for 44.29% of all hospitalizations. The Northeast region had the highest IHM rate (2.86 deaths/100 admissions), with an increasing trend (y = 0.1105x + 1.110; R2 = 0.6265; P < 0.0001), but the lowest hospitalization rate (1.15). The Midwest and South regions had the highest hospitalization rates (3.27 and 3.17, respectively). A higher IHM rate was observed for nonelective admissions (2.88), which accounted for 81% of IBD hospitalizations. The total cost of IBD hospitalizations in 2017 exhibited an increase of 37.5% compared to 2008. CONCLUSION There has been a notable reduction in the number of hospitalizations for IBD in Brazil over 20 years. IHM rates varied and did not follow a linear trend.

OBJECTIVE: To perform a sistematiy review of the literature about the nutritional impact of inflammatory bowel diseases in children and adolescents.DATA SOURCES: A systematic review was performed using PubMed/MEDLINE, LILACS and SciELO databases, with inclusion of articles in Portuguese and in English with original data, that analyzed nutritional aspects of inflammatory bowel diseases in children and adolescents. The initial search used the terms "inflammatory bowel diseases" and "children" or "adolescents" and "nutritional evaluation" or "nutrition deficiency". The selection of studies was initially performed by reading the titles and abstracts. Review studies and those withouth data for pediatric patients were excluded. Subsequently, the full reading of the articles considered relevant was performed.RESULTS: 237 studies were identified, and 12 of them were selected according to the inclusion criteria. None of them was performed in South America. During the analysis of the studies, it was observed that nutritional characteristics of patients with inflammatory bowel disease may be altered; the main reports were related to malnutrition, growth stunting, delayed puberty and vitamin D deficiency.CONCLUSION: There are nutritional consequences of inflammatory bowel diseases in children and adolescents, mainly growth stunting, slower pubertal development, underweight and vitamin deficiencies. Nutritional impairments were more significant in patients with Crohn's disease; overweight and obesity were more common in patients with ulcerative rectocolitis. A detailed nutritional assessment should be performed periodically in children and adolescents with inflammatory bowel disease. OBJETIVO: Realizar revisão sistemática de literatura sobre repercussões nutricionais em crianças e adolescentes na presença de doenças inflamatórias intestinais.FONTES DE DADOS: Realizada revisão sistemática utilizando as bases de dados PubMed/MEDLINE, LILACS e SciELO, com inclusão de artigos em língua portuguesa e inglesa com dados originais que analisaram aspectos nutricionais de crianças ou adolescentes com doenças inflamatórias intestinais. Na busca inicial, utilizaram-se os termos "inflammatory bowel diseases" and "children" or "adolescents" and "nutritional evaluation" or "nutrition deficiency". A seleção de estudos foi feita, inicialmente, por meio da leitura dos títulos e resumos. Foram excluídos estudos de revisão e sem resultados para faixa pediátrica. Em um segundo momento, foi realizada leitura completa dos artigos considerados relevantes.SÍNTESE DE DADOS: Foram identificados 237 estudos - desses, 12 foram selecionados de acordo com os critérios de inclusão, não havendo nenhum na América do Sul. Na análise dos artigos, foi observado que características nutricionais em pacientes com doenças inflamatórias intestinais podem estar alteradas, sendo relatados principalmente desnutrição, retardo de crescimento e puberdade e deficiência de vitamina D.CONCLUSÃO: Há alterações nutricionais nas doenças inflamatórias intestinais em pediatria, ressaltando-se parada no crescimento e desenvolvimento puberal, baixo peso e deficiências vitamínicas. Os comprometimentos nutricionais relatados são mais expressivos nos pacientes portadores de Doença de Crohn, e sobrepeso e obesidade mais frequentes na Retocolite Ulcerativa. A avaliação nutricional detalhada deve ser realizada periodicamente em todas crianças e adolescentes portadores de doenças inflamatórias intestinais.

Submitted by ROBERTO PAULO CORREIA DE ARAÚJO (ppgorgsistem@ufba.br) on 2017-06-19T16:59:53Z No. of bitstreams: 1 12_v.12_3.pdf: 490577 bytes, checksum: 73475c73a05bb6c5134361da49794543 (MD5) Made available in DSpace on 2017-06-19T16:59:53Z (GMT). No. of bitstreams: 1 12_v.12_3.pdf: 490577 bytes, checksum: 73475c73a05bb6c5134361da49794543 (MD5) Previous issue date: 2013-09 Introdução: as doenças inflamatórias intestinais são doenças heterogêneas, decorrentes de um processo inflamatório crônico e que se iniciam na faixa etária pediátrica em torno de 25% dos casos. As crianças, em geral, apresentam quadros iniciais mais graves e extensos da doença e importante comprometimento nutricional. Nas últimas décadas, estudos epidemiológicos evidenciaram um aumento da incidência dessas patologias. Objetivo: avaliar uma série de casos de crianças e adolescentes com doenças inflamatórias intestinais, atendidas em um ambulatório especializado no Estado da Bahia, no ano de 2012. Metodologia: os pacientes foram selecionados através de busca ativa dos prontuários, com os seguintes critérios de inclusão: acompanhamento regular no serviço, diagnosticados no período de janeiro de 2006 a dezembro de 2012, com critérios clínicos, radiológicos, endoscópicos e/ou histopatológicos que comprovassem o diagnóstico de doença inflamatória intestinal. Resultados: foram selecionados 30 pacientes e houve predominância do diagnóstico de RCU, quando comparada à DC (60% e 40%, respectivamente). Os sintomas tiveram início antes dos 10 anos de idade em 70% dos pacientes. O período entre o início dos sintomas das DII e o diagnóstico foi superior a 1 ano em 46,6% dos casos. A relação peso para idade foi abaixo do percentil 3 em 60% dos pacientes ao diagnóstico. Conclusão: é necessária uma maior divulgação de protocolos diagnósticos com o objetivo de ampliar o conhecimento dos pediatras acerca das doenças inflamatórias intestinais, a fim de que o diagnóstico seja mais precoce e o encaminhamento feito de modo adequado para os serviços de referência Salvador

p. 1-7 Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-04-24T12:37:41Z No. of bitstreams: 1 1756-0500-6-387.pdf: 215699 bytes, checksum: ffb1f87439dfa7a5735fe0b041e27cf1 (MD5) Approved for entry into archive by Solange Gomes (soldella@ufba.br) on 2014-07-22T13:46:26Z (GMT) No. of bitstreams: 1 1756-0500-6-387.pdf: 215699 bytes, checksum: ffb1f87439dfa7a5735fe0b041e27cf1 (MD5) Made available in DSpace on 2014-07-22T13:46:26Z (GMT). No. of bitstreams: 1 1756-0500-6-387.pdf: 215699 bytes, checksum: ffb1f87439dfa7a5735fe0b041e27cf1 (MD5) Previous issue date: 2013 Background: Most Crohn’s disease (CD) genes discovered in recent years are associated with biological systems critical to the development of this disease. TGFB1 and IL10 are cytokines with important roles in CD. The aim of this study was to evaluate the association between CD, its clinical features and TGFB1 and IL10 gene polymorphisms. Methods: This case–control study enrolled 91 patients and 91 controls from the state of Bahia, Brazil. Five single nucleotide polymorphisms (SNPs) were studied in the TGFB1 gene (codon 10 T > C - rs1800470; codon 25 G > C - rs1800471) and IL10 gene (−1082 A > G - rs1800896; -819 T > C - rs1800871; -592 A > C - rs1800872). An analysis of the genetic polymorphisms was performed using a commercial kit. A comparison of allele frequencies and genotypes was estimated by calculating the odds ratio (OR) with a confidence interval adjusted via the Bonferroni test for a local alpha of 1%. A stratified analysis was applied for gender, race and smoking history. Patients with CD were characterized according to the Montreal classification. Results: The C allele and CC genotype of the TGFB1 gene rs1800470 were both significantly associated with CD. The stratified analysis showed no confounding factors for the co-variables of gender, race and smoking history. The IL10 gene rs1800896 G allele was significantly associated with age at diagnosis of CD, while the T allele of the IL10 gene rs1800871 was significantly associated with perianal disease. The SNPs rs1800871 and rs1800872 were in 100% linkage disequilibrium. Conclusions: TGFB1 gene polymorphisms may be associated with susceptibility to the development of CD, and IL10 gene polymorphisms appear to influence the CD phenotype in this admixed population.

p. 5028-5031 Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-02-13T15:04:32Z No. of bitstreams: 1 André Castro Lyra.pdf: 762804 bytes, checksum: 62361fef0df59145c8b13ad3b56ff5ba (MD5) Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-10-21T16:47:01Z (GMT) No. of bitstreams: 1 André Castro Lyra.pdf: 762804 bytes, checksum: 62361fef0df59145c8b13ad3b56ff5ba (MD5) Made available in DSpace on 2014-10-21T16:47:01Z (GMT). No. of bitstreams: 1 André Castro Lyra.pdf: 762804 bytes, checksum: 62361fef0df59145c8b13ad3b56ff5ba (MD5) Previous issue date: 2011 Crohn’s disease is a chronic inflammatory disorder of the gastrointestinal tract that is defined by relapsing and remitting episodes. Tumor necrosis factor alpha (TNF-α) appears to play a central role in the pathophysiology of the disease. Standard therapies for inflammatory bowel disease fail to induce remission in about 30% of patients. Biological therapies have been associated with an increased incidence of infections, especially infection by Mycobacterium tuberculosis (Mtb). Thalidomide is an oral immunomodulatory agent with anti-TNF-α properties. Recent studies have suggested that thalidomide is effective in refractory luminal and fistulizing Crohn’s disease. Thalidomide costimulates T lymphocytes, with greater effect on CD8+ than on CD4+ T cells, which contributes to the protective immune response to Mtb infection. We present a case of Crohn’s disease with gastric, ileal, colon and rectum involvement as well as steroid dependency, which progressed with loss of response to infliximab after three years of therapy. The thorax computed tomography scan demonstrated a pulmonary nodule suspected to be Mtb infection. The patient was started on thalidomide therapy and exhibited an excellent response.

Texto completo: acesso restrito. p. 676-679 Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-10-02T14:27:54Z No. of bitstreams: 1 S0007114508032224a.pdf: 131072 bytes, checksum: b2a0eacdb96bc395ba80ca43408531c9 (MD5) Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2013-11-06T20:11:38Z (GMT) No. of bitstreams: 1 S0007114508032224a.pdf: 131072 bytes, checksum: b2a0eacdb96bc395ba80ca43408531c9 (MD5) Made available in DSpace on 2013-11-06T20:11:38Z (GMT). No. of bitstreams: 1 S0007114508032224a.pdf: 131072 bytes, checksum: b2a0eacdb96bc395ba80ca43408531c9 (MD5) Previous issue date: 2009 Inflammatory bowel disease (IBD) is often associated with malnutrition. The aim of this study was to compare the body composition of outpatients with IBD during remission and active phase. In order to evaluate disease activity we used Crohn's Disease Activity Index for Crohn's disease (CD) patients and Lichtiger's Index for ulcerative colitis (UC) patients. All patients underwent the analysis of BMI, arm muscle area (AMA) and triceps plus subscapula skinfold thickness (TST+SST) to identify total, muscle and fat mass, respectively. In total 102 patients were evaluated (CD, n 50; UC, n 52) and the majority was young women. Malnutrition according to BMI was found in 14·0 % of patients with CD and 5·7 % of UC patients. Muscle mass depletion was detected in more than half of the CD and UC patients. The BMI, TST+SST and AMA values were lower in the active phase only in CD patients (P < 0·05). Fat mass depletion was associated with active phase in both CD and UC patients. Body composition parameters obtained using BMI, TST+SST and AMA were not correlated with the presence of fistula in CD patients (P>0·05). In conclusion, patients without signs of malnutrition had fat mass depletion especially in the active phase and muscle mass depletion occurred both in CD and UC patients.

BACKGROUND: Crohn’s disease is a chronic inflammatory disorder with diversity on its clinical presentation that may be observed from the varying age of onset of symptoms to the site of occurrence of the illness. There is a need for a replicable and uniform description of the disease allowing a comparison between distinct study populations. The 1998 Vienna classification characterizes patients according to three clinical aspects: age at diagnosis, location and disease behavior. AIM: To describe Crohn’s disease in patients from a reference center of Salvador, BA, Brazil according to the Vienna classification. METHODS: Between January and October of 2005, patients (n = 47) having at least one endoscopic and radiological examination of the intestine participated in this study. RESULTS: Most of the participants had the diagnosis of the disease when they were younger than 40 years old (70.2%) while an ileocolic location (38.3%) and the penetrating form (46.8%) were the most prevalent clinical presentation. The restricted location of the ileum (L1) was more frequent in nonstricturing, nonpenetrating disease (B1) while the ileocolic disease (L3) was more associated with the penetrating behavior (B3). CONCLUSION: In this study, differently from the first description of the Vienna classification, the large number of patients presenting a complicated stage of the disease can be attributed to the fact that it was carried out at a reference center, where many patients present with the disease at an advanced stage. RACIONAL: A doença de Crohn é um distúrbio inflamatório crônico com apresentação clínica diversa, o que pode ser observado desde a variação da idade de início dos sintomas até o local de ocorrência da doença. Existe a necessidade de uma descrição uniforme e replicável da doença que permita comparação entre diferentes populações estudadas. A classificação de Viena de 1998 caracteriza os pacientes de acordo com três aspectos clínicos: idade do diagnóstico, localização e comportamento da doença. OBJETIVO: Descrever a doença de Crohn em pacientes de um centro de referência de Salvador, BA, de acordo com a classificação de Viena. MÉTODO: Entre janeiro e outubro de 2005, participaram deste estudo pacientes (n = 47) que tiveram pelo menos um exame endoscópico ou radiológico do intestino. RESULTADOS: A maioria dos participantes teve o diagnóstico da doença com idade menor do que 40 anos (70.2%), enquanto a localização íleo-colônica (38,3%) e a forma penetrante (46,8%) foram as apresentações clínicas mais prevalentes. A localização restrita ao íleo (L1) foi mais freqüente na doença não-estenosante não-penetrante (B1), enquanto a doença íleo-colônica (L3) foi mais associada com o comportamento penetrante (B3). CONCLUSÃO: Neste estudo, diferente da descrição inicial da classificação de Viena, o grande número de pacientes apresentando-se com fase complicada da doença pode ser atribuído ao fato de ter sido realizado em um centro de referência, onde muitos pacientes comparecem com a doença avançada.

BACKGROUND: Crohn’s disease is a chronic inflammatory disorder with diversity on its clinical presentation that may be observed from the varying age of onset of symptoms to the site of occurrence of the illness. There is a need for a replicable and uniform description of the disease allowing a comparison between distinct study populations. The 1998 Vienna classification characterizes patients according to three clinical aspects: age at diagnosis, location and disease behavior. AIM: To describe Crohn’s disease in patients from a reference center of Salvador, BA, Brazil according to the Vienna classification. METHODS: Between January and October of 2005, patients (n = 47) having at least one endoscopic and radiological examination of the intestine participated in this study. RESULTS: Most of the participants had the diagnosis of the disease when they were younger than 40 years old (70.2%) while an ileocolic location (38.3%) and the penetrating form (46.8%) were the most prevalent clinical presentation. The restricted location of the ileum (L1) was more frequent in nonstricturing, nonpenetrating disease (B1) while the ileocolic disease (L3) was more associated with the penetrating behavior (B3). CONCLUSION: In this study, differently from the first description of the Vienna classification, the large number of patients presenting a complicated stage of the disease can be attributed to the fact that it was carried out at a reference center, where many patients present with the disease at an advanced stage.

p.64-68 Submitted by Texeira Ana (atanateixeira@gmail.com) on 2012-05-30T11:46:17Z No. of bitstreams: 1 Santana, Genoile Oliveira.pdf: 169724 bytes, checksum: 08886b712ae3aaf2a6944dad20d6b882 (MD5) Made available in DSpace on 2012-05-30T11:46:17Z (GMT). No. of bitstreams: 1 Santana, Genoile Oliveira.pdf: 169724 bytes, checksum: 08886b712ae3aaf2a6944dad20d6b882 (MD5) Previous issue date: 2008-01 Background - Crohn’s disease is a chronic inflammatory disorder with diversity on its clinical presentation that may be observed from the varying age of onset of symptoms to the site of occurrence of the illness. There is a need for a replicable and uniform description of the disease allowing a comparison between distinct study populations. The 1998 Vienna classification characterizes patients according to three clinical aspects: age at diagnosis, location and disease behavior. Aim - To describe Crohn’s disease in patients from a reference center of Salvador, BA, Brazil according to the Vienna classification. Methods - Between January and October of 2005, patients (n = 47) having at least one endoscopic and radiological examination of the intestine participated in this study. Results - Most of the participants had the diagnosis of the disease when they were younger than 40 years old (70.2%) while an ileocolic location (38.3%) and the penetrating form (46.8%) were the most prevalent clinical presentation. The restricted location of the ileum (L1) was more frequent in nonstricturing, nonpenetrating disease (B1) while the ileocolic disease (L3) was more associated with the penetrating behavior (B3). Conclusion - In this study, differently from the first description of the Vienna classification, the large number of patients presenting a complicated stage of the disease can be attributed to the fact that it was carried out at a reference center, where many patients present with the disease at an advanced stage. São Paulo

p. 4489-4492 Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-01-20T12:45:25Z No. of bitstreams: 1 Genoile Santana.pdf: 271908 bytes, checksum: 60b7ccc4ebaa5f803195596598ac59eb (MD5) Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2014-09-09T15:50:23Z (GMT) No. of bitstreams: 1 Genoile Santana.pdf: 271908 bytes, checksum: 60b7ccc4ebaa5f803195596598ac59eb (MD5) Made available in DSpace on 2014-09-09T15:50:23Z (GMT). No. of bitstreams: 1 Genoile Santana.pdf: 271908 bytes, checksum: 60b7ccc4ebaa5f803195596598ac59eb (MD5) Previous issue date: 2007 Aim: To evaluate the classification and severity of Crohn's disease in different racial groups. Methods: Patients with Crohn's disease from the outpatient clinic of the University Hospital Prof. Edgard Santos were enrolled in the study. This hospital is a reference centre for inflammatory bowel disease. Race was determined using self-identification. The Vienna's classification was applied for all subjects. The severity of Crohn's disease was determined according to the number of surgical procedures, hospital admissions in the last year and treatment with steroids and immunosuppressors. Statistical analysis was calculated using t test for means, χ 2 or F for proportions. A P value < 0.05 was considered to be significant. Results: Sixty-five patients were enrolled. Non-white patients were more frequently diagnosed with Crohn's disease in the age less than 40 years than white patients. The behaviour of disease was similar in both groups with a high frequency of the penetrating form. There was a tendency for non-white patients to have a greater frequency of hospital admissions in the last year compared to white subjects. Non-whites also had a higher rate of colonic and upper gastrointestinal involvement, and were also more frequently on treatment with immunossupressors than white patients although this difference was not statistically significant. Conclusion: Non-white patients with Crohn's disease had an earlier diagnosis and appeared to have had a more severe disease presentation than white patients. © 2007 WJG. All rights reserved.

Texto completo: acesso restrito. p. 333-336 Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2013-11-26T12:40:26Z No. of bitstreams: 1 Bendicho, Maria Teresita.pdf: 80876 bytes, checksum: cbcd188061e770e70be4f5523bbd75eb (MD5) Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-11-26T13:00:47Z (GMT) No. of bitstreams: 1 Bendicho, Maria Teresita.pdf: 80876 bytes, checksum: cbcd188061e770e70be4f5523bbd75eb (MD5) Made available in DSpace on 2013-11-26T13:00:47Z (GMT). No. of bitstreams: 1 Bendicho, Maria Teresita.pdf: 80876 bytes, checksum: cbcd188061e770e70be4f5523bbd75eb (MD5) Previous issue date: 2005 Objectives: The polymorphisms in cytokine genes have allowed for the understanding of the genetic determinants of diseases. The aims of this study were to describe and compare the frequencies of polymorphisms on the interleukin (IL)-6, IL-10, tumor necrosis factor (TNF)-[alpha], transforming growth factor (TGF)-[beta]1, and interferon (IFN)-[gamma] genes between patients with chronic pancreatitis (CP) and healthy individuals from Bahia, Brazil. Methods: Twenty-eight individuals were evaluated at a university gastroenterology outpatient service (4 women and 24 men), all diagnosed with CP based on clinical and radiologic aspects. The control group was composed of 94 (11 women and 83 men) blood donors. The polymorphisms studied were TNF-[alpha] (-308G/A), TGF-[beta]1 (codon 10C/T, codon 25C/G), IL-10 (-1082A/G; -819T/C; -592A/C), IL-6 (-174G/C), and IFN-[gamma] (+874T/A). Results: A statistically significant difference was observed in the frequency of the polymorphisms between the group of patients with CP and the group of healthy individuals with the polymorphism of the TGF-[beta]1 gene on codon 10. No statistically significant differences were found for the allele and genotypic frequencies on the genes that code TNF-[alpha], IFN-[gamma], IL-10, and TGF-[beta]1 codon 25, and IL-6 between the control and case groups. Conclusion: The genotypes corresponding to the high TGF-[beta]1 producer phenotypes can be associated with the fibrogenesis shown with CP.

p.24-31 Submitted by Texeira Ana (atanateixeira@gmail.com) on 2012-05-30T13:54:26Z No. of bitstreams: 1 Santana, Genoile Oliveira(2).pdf: 187725 bytes, checksum: d600f7e1c2d2edfbedb329ea6605f823 (MD5) Made available in DSpace on 2012-05-30T13:54:26Z (GMT). No. of bitstreams: 1 Santana, Genoile Oliveira(2).pdf: 187725 bytes, checksum: d600f7e1c2d2edfbedb329ea6605f823 (MD5) Previous issue date: 2001-01 Racional - A prevalência da infecção pelo vírus da hepatite C em pacientes sob programa de hemodiálise tem sido amplamente variável. Objetivos – Determinar a prevalência do anticorpo contra o vírus C da hepatite (anti-VHC) em pacientes sob hemodiálise em Salvador, BA e sua associação com transfusão de sangue, duração de hemodiálise e elevação de alaninoaminotransferase. Métodos - Durante um período de 17 meses, foram avaliados todos os pacientes em programa de hemodiálise, totalizando 395 indivíduos, que responderam a questionário e forneceram soro para análise laboratorial (alaninoaminotransferase sérica e anti-VCH pelo ELISA II com confirmação pelo Immunoblotting (RIBA III). Resultados - O anti-VHC foi positivo em 23,8% (94/395). A presença de transfusão mostrou associação com o anti-VHC e quanto maior o número de transfusões, mais freqüente o anti-VHC. Dos pacientes que nunca foram transfundidos, 12,5% (6/48) foram anti-VHC positivos. A duração do tratamento dialítico foi de 53,44 ± 36,45 meses no grupo anti-VHC positivo e de 22,10 ± 22,75 meses no grupo negativo. A elevação de alaninoaminotransferase foi mais freqüente no grupo positivo para o anti-VHC. A positividade para as frações do RIBA III foi de 79,8%, 100%, 80,9% e 52,1% para o c100- 3, c33, c22 e NS5, respectivamente. O anti-NS5 foi ainda menos freqüente no grupo com alaninoaminotransferase elevada. Conclusões - A prevalência do anti-VHC em pacientes sob hemodiálise crônica de Salvador, BA é elevada e está associada com transfusão de sangue, maior duração de tratamento dialítico e elevação de alaninoaminotransferase. São Paulo

Submitted by Pos-Graduação Medicina e Saúde (ppgms@ufba.br) on 2017-08-23T18:28:24Z No. of bitstreams: 1 MENDES CAL-2014.pdf: 2126720 bytes, checksum: 0269d5d110a55f6c691c07c866808922 (MD5) Approved for entry into archive by Edvaldo Souza (edvaldosouza@ufba.br) on 2017-09-18T17:58:27Z (GMT) No. of bitstreams: 1 MENDES CAL-2014.pdf: 2126720 bytes, checksum: 0269d5d110a55f6c691c07c866808922 (MD5) Made available in DSpace on 2017-09-18T17:58:27Z (GMT). No. of bitstreams: 1 MENDES CAL-2014.pdf: 2126720 bytes, checksum: 0269d5d110a55f6c691c07c866808922 (MD5) Introdução: A doença inflamatória intestinal está associada com baixa densidade mineral óssea. Nosso objetivo foi avaliar a associação entre gravidade de doença e DMO em pacientes com DII. Métodos: Trata-se de um estudo transversal de prevalência com grupo de comparação, realizado com pacientes com DII. Todos os pacientes e controles realizaram densitometria óssea. Nos pacientes com DII, foram analisados uso de medicações, internação, localização, extensão e fenótipo da doença, de acordo com classificação de Montreal. Atividade de doença foi avaliada de acordo com índices de Harvey Bradshaw e Lichtiger. Análise de correspondência múltipla foi utilizada para avaliar variáveis categóricas. Resultados: Foram estudados 68 pacientes com RCU, 60 com DC e 67 pessoas saudáveis. Dentre os pacientes com DC, a maioria teve diagnóstico com idade entre 17 e 40 anos. Doença ileocolônica e não estenosante-não penetrante foi a localização de doença e o comportamento mais frequentes. Em relação a RCU, a colite extensa foi a extensão da doença mais encontrada. Pacientes apresentaram mais osteopenia que os controles. Sexo masculino, doença perianal, doença penetrante e idade de diagnóstico > 40 anos estiveram associados com baixa DMO nos pacientes com DC. Uso de azatioprina e infliximabe foi associado com osteopenia. Nos pacientes com RCU, colite esquerda, uso de corticóides e internação estiveram associados com baixa DMO. Não houve associação entre atividade de doença e osteopenia ou osteoporose. Conclusion: Gravidade de doença parece estar associada com osteopenia em pacientes com DII. Devemos estar atentos a alguns fatores que podem estar relacionados com essa perda óssea como doença perianal, comportamento penetrante e uso de azatioprina e infliximabe em pacientes com DC e colite esquerda em pacientes com RCU.