121 results on '"Samieri, Cecilia"'
Search Results
2. Time-varying exposure history and subsequent health outcomes: a two-stage approach to identify critical windows
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Wagner, Maude, Grodstein, Francine, Leffondre, Karen, Samieri, Cécilia, and Proust-Lima, Cécile
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Statistics - Methodology ,Statistics - Applications - Abstract
Long-term behavioral and health risk factors constitute a primary focus of research on the etiology of chronic diseases. Yet, identifying critical time-windows during which risk factors have the strongest impact on disease risk is challenging. To assess the trajectory of association of an exposure history with an outcome, the weighted cumulative exposure index (WCIE) has been proposed, with weights reflecting the relative importance of exposures at different times. However, WCIE is restricted to a complete observed error-free exposure whereas exposures are often measured with intermittent missingness and error. Moreover, it rarely explores exposure history that is very distant from the outcome as usually sought in life-course epidemiology. We extend the WCIE methodology to (i) exposures that are intermittently measured with error, and (ii) contexts where the exposure time-window precedes the outcome time-window using a landmark approach. First, the individual exposure history up to the landmark time is estimated using a mixed model that handles missing data and error in exposure measurement, and the predicted complete error-free exposure history is derived. Then the WCIE methodology is applied to assess the trajectory of association between the predicted exposure history and the health outcome collected after the landmark time. In our context, the health outcome is a longitudinal marker analyzed using a mixed model. A simulation study first demonstrates the correct inference obtained with this approach. Then, applied to the Nurses' Health Study (19,415 women) to investigate the association between BMI history (collected from midlife) and subsequent cognitive decline after age 70. In conclusion, this approach, easy to implement, provides a flexible tool for studying complex dynamic relationships and identifying critical time windows while accounting for exposure measurement errors., Comment: Pages 35, Main Figures 5, Web Figures 13, Work presented at the Alzheimers Association International eConference (2020), eMELODEM conference, MEthods for LOngitudinal studies in DEMentia (2020), and ISCB, International Society for Clinical Biostatistics (2019)
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- 2020
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3. Omega-3 Blood Levels and Stroke Risk: A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies
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O’Keefe, James H., Tintle, Nathan L., Harris, William S., O’Keefe, Evan L., Sala-Vila, Aleix, Attia, John, Garg, G. Manohar, Hure, Alexis, Bork, Christian Sørensen, Schmidt, Erik Berg, Venø, Stine Krogh, Chien, Kuo-Liong, Chen, Yun-Yu (Amelia), Egert, Sarah, Feldreich, Tobias Rudholm, Ärnlöv, Johan, Lind, Lars, Forouhi, Nita G., Geleijnse, Johanna M., Pertiwi, Kamalita, Imamura, Fumiaki, de Mello Laaksonen, Vanessa, Uusitupa, W. Matti, Tuomilehto, Jaakko, Laakso, Markku, Lankinen, Maria Anneli, Laurin, Danielle, Carmichael, Pierre-Hugues, Lindsay, Joan, Leander, Karin, Laguzzi, Federica, Swenson, Brenton R., Longstreth, William T., Manson, JoAnn E., Mora, Samia, Cook, Nancy R., Marklund, Matti, Melo van Lent, Debora, Murphy, Rachel, Gudnason, Vilmundur, Ninomiya, Toshihara, Hirakawa, Yoichiro, Qian, Frank, Sun, Qi, Hu, Frank, Ardisson Korat, Andres V., Risérus, Ulf, Lázaro, Iolanda, Samieri, Cecilia, Le Goff, Mélanie, Helmer, Catherine, Steur, Marinka, Voortman, Trudy, Ikram, M. Kamran, Tanaka, Toshiko, Das, Jayanta K., Ferrucci, Luigi, Bandinelli, Stefania, Tsai, Michael, Guan, Weihua, Garg, Parveen, Verschuren, W.M. Monique, Boer, Jolanda M.A., Biokstra, Anneke, Virtanen, Jyrki, Wagner, Michael, Westra, Jason, Albuisson, Luc, Yamagishi, Kazumasa, Siscovick, David S., Lemaitre, Rozenn N., and Mozaffarian, Dariush
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- 2024
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4. Empirical Dietary Inflammatory Pattern Scores Are Not Associated with Worse Cognitive Performance in the Nurses’ Health Study
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Melo van Lent, Debora, Samieri, Cécilia, Grodstein, Francine, and Seshadri, Sudha
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- 2022
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5. Nutrition state of science and dementia prevention: recommendations of the Nutrition for Dementia Prevention Working Group
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Yassine, Hussein N, Samieri, Cécilia, Livingston, Gill, Glass, Kimberly, Wagner, Maude, Tangney, Christy, Plassman, Brenda L, Ikram, M Arfan, Voigt, Robin M, Gu, Yian, O'Bryant, Sid, Minihane, Anne Marie, Craft, Suzanne, Fink, Howard A, Judd, Suzanne, Andrieu, Sandrine, Bowman, Gene L, Richard, Edo, Albensi, Benedict, Meyers, Emily, Khosravian, Serly, Solis, Michele, Carrillo, Maria, Snyder, Heather, Grodstein, Francine, Scarmeas, Nikolaos, and Schneider, Lon S
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- 2022
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6. Mediterranean diet and prudent diet are both associated with low circulating esterified 3-hydroxy fatty acids, a proxy of LPS burden, among older adults
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André, Perrine, Pais de Barros, Jean-Paul, MJ Merle, Bénédicte, Samieri, Cécilia, Helmer, Catherine, Delcourt, Cécile, and Féart, Catherine
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- 2021
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7. Early signature in the blood lipidome associated with subsequent cognitive decline in the elderly: A case-control analysis nested within the Three-City cohort study
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Lefèvre-Arbogast, Sophie, Hejblum, Boris P, Helmer, Catherine, Klose, Christian, Manach, Claudine, Low, Dorrain Y, Urpi-Sarda, Mireia, Andres-Lacueva, Cristina, González-Domínguez, Raúl, Aigner, Ludwig, Altendorfer, Barbara, Lucassen, Paul J, Ruigrok, Silvie R, De Lucia, Chiara, Du Preez, Andrea, Proust-Lima, Cécile, Thuret, Sandrine, Korosi, Aniko, and Samieri, Cécilia
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- 2021
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8. Omega-3 Blood Levels and Stroke Risk : A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies
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O'Keefe, James H., Tintle, Nathan L., Harris, William S., O'Keefe, Evan L., Sala-Vila, Aleix, Attia, John, Garg, G. Manohar, Hure, Alexis, Sørensen Bork, Christian, Berg Schmidt, Erik, Krogh Venø, Stine, Chien, Kuo-Liong, Chen, Yun-Yu Amelia, Egert, Sarah, Rudholm Feldreich, Tobias, Ärnlöv, Johan, Lind, Lars, Forouhi, Nita G., Geleijnse, Johanna M., Pertiwi, Kamalita, Imamura, Fumiaki, de Mello Laaksonen, Vanessa, Uusitupa, W. Matti, Tuomilehto, Jaakko, Laakso, Markku, Lankinen, Maria Anneli, Laurin, Danielle, Carmichael, Pierre-Hugues, Lindsay, Joan, Leander, Karin, Laguzzi, Federica, Swenson, Brenton R., Longstreth, William T., Manson, JoAnn E., Mora, Samia, Cook, Nancy R., Marklund, Matti, Melo van Lent, Debora, Murphy, Rachel, Gudnason, Vilmundur, Ninomiya, Toshihara, Hirakawa, Yoichiro, Qian, Frank, Sun, Qi, Hu, Frank, Ardisson Korat, Andres V., Risérus, Ulf, Lázaro, Iolanda, Samieri, Cecilia, Le Goff, Mélanie, Helmer, Catherine, Steur, Marinka, Voortman, Trudy, Ikram, M. Kamran, Tanaka, Toshiko, Das, Jayanta K., Ferrucci, Luigi, Bandinelli, Stefania, Tsai, Michael, Guan, Weihua, Garg, Parveen, Verschuren, W. M. Monique, Boer, Jolanda M. A., Biokstra, Anneke, Virtanen, Jyrki, Wagner, Michael, Westra, Jason, Albuisson, Luc, Yamagishi, Kazumasa, Siscovick, David S., Lemaitre, Rozenn N., Mozaffarian, Dariush, O'Keefe, James H., Tintle, Nathan L., Harris, William S., O'Keefe, Evan L., Sala-Vila, Aleix, Attia, John, Garg, G. Manohar, Hure, Alexis, Sørensen Bork, Christian, Berg Schmidt, Erik, Krogh Venø, Stine, Chien, Kuo-Liong, Chen, Yun-Yu Amelia, Egert, Sarah, Rudholm Feldreich, Tobias, Ärnlöv, Johan, Lind, Lars, Forouhi, Nita G., Geleijnse, Johanna M., Pertiwi, Kamalita, Imamura, Fumiaki, de Mello Laaksonen, Vanessa, Uusitupa, W. Matti, Tuomilehto, Jaakko, Laakso, Markku, Lankinen, Maria Anneli, Laurin, Danielle, Carmichael, Pierre-Hugues, Lindsay, Joan, Leander, Karin, Laguzzi, Federica, Swenson, Brenton R., Longstreth, William T., Manson, JoAnn E., Mora, Samia, Cook, Nancy R., Marklund, Matti, Melo van Lent, Debora, Murphy, Rachel, Gudnason, Vilmundur, Ninomiya, Toshihara, Hirakawa, Yoichiro, Qian, Frank, Sun, Qi, Hu, Frank, Ardisson Korat, Andres V., Risérus, Ulf, Lázaro, Iolanda, Samieri, Cecilia, Le Goff, Mélanie, Helmer, Catherine, Steur, Marinka, Voortman, Trudy, Ikram, M. Kamran, Tanaka, Toshiko, Das, Jayanta K., Ferrucci, Luigi, Bandinelli, Stefania, Tsai, Michael, Guan, Weihua, Garg, Parveen, Verschuren, W. M. Monique, Boer, Jolanda M. A., Biokstra, Anneke, Virtanen, Jyrki, Wagner, Michael, Westra, Jason, Albuisson, Luc, Yamagishi, Kazumasa, Siscovick, David S., Lemaitre, Rozenn N., and Mozaffarian, Dariush
- Abstract
BACKGROUND: The effect of marine omega-3 PUFAs on risk of stroke remains unclear. METHODS: We investigated the associations between circulating and tissue omega-3 PUFA levels and incident stroke (total, ischemic, and hemorrhagic) in 29 international prospective cohorts. Each site conducted a de novo individual-level analysis using a prespecified analytical protocol with defined exposures, covariates, analytical methods, and outcomes; the harmonized data from the studies were then centrally pooled. Multivariable-adjusted HRs and 95% CIs across omega-3 PUFA quintiles were computed for each stroke outcome. RESULTS: Among 183 291 study participants, there were 10 561 total strokes, 8220 ischemic strokes, and 1142 hemorrhagic strokes recorded over a median of 14.3 years follow-up. For eicosapentaenoic acid, comparing quintile 5 (Q5, highest) with quintile 1 (Q1, lowest), total stroke incidence was 17% lower (HR, 0.83 [CI, 0.76–0.91]; P<0.0001), and ischemic stroke was 18% lower (HR, 0.82 [CI, 0.74–0.91]; P<0.0001). For docosahexaenoic acid, comparing Q5 with Q1, there was a 12% lower incidence of total stroke (HR, 0.88 [CI, 0.81–0.96]; P=0.0001) and a 14% lower incidence of ischemic stroke (HR, 0.86 [CI, 0.78–0.95]; P=0.0001). Neither eicosapentaenoic acid nor docosahexaenoic acid was associated with a risk for hemorrhagic stroke. These associations were not modified by either baseline history of AF or prevalent CVD. CONCLUSIONS: Higher omega-3 PUFA levels are associated with lower risks of total and ischemic stroke but have no association with hemorrhagic stroke.
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- 2024
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9. Omega-3 Blood Levels and Stroke Risk: A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies
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Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, O'Keefe, James H, Tintle, Nathan L, Harris, William S, O'Keefe, Evan L, Sala-Vila, Aleix, Attia, John, Garg, G Manohar, Hure, Alexis, Bork, Christian Sørensen, Schmidt, Erik Berg, Venø, Stine Krogh, Chien, Kuo-Liong, Chen, Yun-Yu Amelia, Egert, Sarah, Feldreich, Tobias Rudholm, Ärnlöv, Johan, Lind, Lars, Forouhi, Nita G, Geleijnse, Johanna M, Pertiwi, Kamalita, Imamura, Fumiaki, de Mello Laaksonen, Vanessa, Uusitupa, W Matti, Tuomilehto, Jaakko, Laakso, Markku, Lankinen, Maria Anneli, Laurin, Danielle, Carmichael, Pierre-Hugues, Lindsay, Joan, Leander, Karin, Laguzzi, Federica, Swenson, Brenton R, Longstreth, William T, Manson, JoAnn E, Mora, Samia, Cook, Nancy R, Marklund, Matti, Melo van Lent, Debora, Murphy, Rachel, Gudnason, Vilmundur, Ninomiya, Toshihara, Hirakawa, Yoichiro, Qian, Frank, Sun, Qi, Hu, Frank, Ardisson Korat, Andres V, Risérus, Ulf, Lázaro, Iolanda, Samieri, Cecilia, Le Goff, Mélanie, Helmer, Catherine, Steur, Marinka, Voortman, Trudy, Ikram, M Kamran, Tanaka, Toshiko, Das, Jayanta K, Ferrucci, Luigi, Bandinelli, Stefania, Tsai, Michael, Guan, Weihua, Garg, Parveen, Verschuren, W M Monique, Boer, Jolanda M A, Biokstra, Anneke, Virtanen, Jyrki, Wagner, Michael, Westra, Jason, Albuisson, Luc, Yamagishi, Kazumasa, Siscovick, David S, Lemaitre, Rozenn N, Mozaffarian, Dariush, Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, O'Keefe, James H, Tintle, Nathan L, Harris, William S, O'Keefe, Evan L, Sala-Vila, Aleix, Attia, John, Garg, G Manohar, Hure, Alexis, Bork, Christian Sørensen, Schmidt, Erik Berg, Venø, Stine Krogh, Chien, Kuo-Liong, Chen, Yun-Yu Amelia, Egert, Sarah, Feldreich, Tobias Rudholm, Ärnlöv, Johan, Lind, Lars, Forouhi, Nita G, Geleijnse, Johanna M, Pertiwi, Kamalita, Imamura, Fumiaki, de Mello Laaksonen, Vanessa, Uusitupa, W Matti, Tuomilehto, Jaakko, Laakso, Markku, Lankinen, Maria Anneli, Laurin, Danielle, Carmichael, Pierre-Hugues, Lindsay, Joan, Leander, Karin, Laguzzi, Federica, Swenson, Brenton R, Longstreth, William T, Manson, JoAnn E, Mora, Samia, Cook, Nancy R, Marklund, Matti, Melo van Lent, Debora, Murphy, Rachel, Gudnason, Vilmundur, Ninomiya, Toshihara, Hirakawa, Yoichiro, Qian, Frank, Sun, Qi, Hu, Frank, Ardisson Korat, Andres V, Risérus, Ulf, Lázaro, Iolanda, Samieri, Cecilia, Le Goff, Mélanie, Helmer, Catherine, Steur, Marinka, Voortman, Trudy, Ikram, M Kamran, Tanaka, Toshiko, Das, Jayanta K, Ferrucci, Luigi, Bandinelli, Stefania, Tsai, Michael, Guan, Weihua, Garg, Parveen, Verschuren, W M Monique, Boer, Jolanda M A, Biokstra, Anneke, Virtanen, Jyrki, Wagner, Michael, Westra, Jason, Albuisson, Luc, Yamagishi, Kazumasa, Siscovick, David S, Lemaitre, Rozenn N, and Mozaffarian, Dariush
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- 2024
10. Associations of circulating very-long-chain saturated fatty acids and incident type 2 diabetes: a pooled analysis of prospective cohort studies
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Fretts, Amanda M, Imamura, Fumiaki, Marklund, Matti, Micha, Renata, Wu, Jason H Y, Murphy, Rachel A, Chien, Kuo-Liong, McKnight, Barbara, Tintle, Nathan, Forouhi, Nita G, Qureshi, Waqas T, Virtanen, Jyrki K, Wong, Kerry, Wood, Alexis C, Lankinen, Maria, Rajaobelina, Kalina, Harris, Tamara B, Djoussé, Luc, Harris, Bill, Wareham, Nick J, Steffen, Lyn M, Laakso, Markku, Veenstra, Jenna, Samieri, Cécilia, Brouwer, Ingeborg A, Yu, Chaoyu Ian, Koulman, Albert, Steffen, Brian T, Helmer, Catherine, Sotoodehnia, Nona, Siscovick, David, Gudnason, Vilmundur, Wagenknecht, Lynne, Voutilainen, Sari, Tsai, Michael Y, Uusitupa, Matti, Kalsbeek, Anya, Berr, Claudine, Mozaffarian, Dariush, and Lemaitre, Rozenn N
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- 2019
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11. A universal approximate cross-validation criterion and its asymptotic distribution
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Commenges, Daniel, Proust-Lima, Cécile, Samieri, Cécilia, and Liquet, Benoit
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Mathematics - Statistics Theory ,62F99 - Abstract
A general framework is that the estimators of a distribution are obtained by minimizing a function (the estimating function) and they are assessed through another function (the assessment function). The estimating and assessment functions generally estimate risks. A classical case is that both functions estimate an information risk (specifically cross entropy); in that case Akaike information criterion (AIC) is relevant. In more general cases, the assessment risk can be estimated by leave-one-out crossvalidation. Since leave-one-out crossvalidation is computationally very demanding, an approximation formula can be very useful. A universal approximate crossvalidation criterion (UACV) for the leave-one-out crossvalidation is given. This criterion can be adapted to different types of estimators, including penalized likelihood and maximum a posteriori estimators, and of assessment risk functions, including information risk functions and continuous rank probability score (CRPS). This formula reduces to Takeuchi information criterion (TIC) when cross entropy is the risk for both estimation and assessment. The asymptotic distribution of UACV and of a difference of UACV is given. UACV can be used for comparing estimators of the distributions of ordered categorical data derived from threshold models and models based on continuous approximations. A simulation study and an analysis of real psychometric data are presented., Comment: 23 pages, 2 figures
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- 2012
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12. Interaction of methylation-related genetic variants with circulating fatty acids on plasma lipids: a meta-analysis of 7 studies and methylation analysis of 3 studies in the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium
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Ma, Yiyi, Follis, Jack L, Smith, Caren E, Tanaka, Toshiko, Manichaikul, Ani W, Chu, Audrey Y, Samieri, Cecilia, Zhou, Xia, Guan, Weihua, Wang, Lu, Biggs, Mary L, Chen, Yii-Der I, Hernandez, Dena G, Borecki, Ingrid, Chasman, Daniel I, Rich, Stephen S, Ferrucci, Luigi, Irvin, Marguerite Ryan, Aslibekyan, Stella, Zhi, Degui, Tiwari, Hemant K, Claas, Steven A, Sha, Jin, Kabagambe, Edmond K, Lai, Chao-Qiang, Parnell, Laurence D, Lee, Yu-Chi, Amouyel, Philippe, Lambert, Jean-Charles, Psaty, Bruce M, King, Irena B, Mozaffarian, Dariush, McKnight, Barbara, Bandinelli, Stefania, Tsai, Michael Y, Ridker, Paul M, Ding, Jingzhong, Mstat, Kurt Lohmant, Liu, Yongmei, Sotoodehnia, Nona, Barberger-Gateau, Pascale, Steffen, Lyn M, Siscovick, David S, Absher, Devin, Arnett, Donna K, Ordovás, José M, and Lemaitre, Rozenn N
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- 2016
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13. Association of omega 3 polyunsaturated fatty acids with incident chronic kidney disease : pooled analysis of 19 cohorts
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Ong, Kwok Leung, Marklund, Matti, Huang, Liping, Rye, Kerry-Anne, Hui, Nicholas, Pan, Xiong-Fei, Rebholz, Casey M., Kim, Hyunju, Steffen, Lyn M., Westing, Anniek C. van, Geleijnse, Johanna M., Hoogeveen, Ellen K., Chen, Yun-Yu, Chien, Kuo-Liong, Fretts, Amanda M., Lemaitre, Rozenn N., Imamura, Fumiaki, Forouhi, Nita G., Wareham, Nicholas J., Birukov, Anna, Jaeger, Susanne, Kuxhaus, Olga, Schulze, Matthias B., Mello, Vanessa Derenji de, Tuomilehto, Jaakko, Uusitupa, Matti, Lindstroem, Jaana, Tintle, Nathan, Harris, William S., Yamasaki, Keisuke, Hirakawa, Yoichiro, Ninomiya, Toshiharu, Tanaka, Toshiko, Ferrucci, Luigi, Bandinelli, Stefania, KVirtanen, Jyrki, Voutilainen, Ari, Jayasena, Tharusha, Thalamuthu, Anbupalam, Poljak, Anne, Bustamante, Sonia, Sachdev, Perminder S., Senn II, Mackenzie K, Rich, Stephen S., Tsai, Michael Y., Wood, Alexis C., Laakso, Markku, Lankinen, Maria, Yang, Xiaowei, Sun, Liang, Li, Huaixing, Lin, Xu, Nowak, Christoph, Ärnlöv, Johan, Risérus, Ulf, Lind, Lars, Le Goff, Melanie, Samieri, Cecilia, Helmer, Catherine, Qian, Frank, Micha, Renata, Tin, Adrienne, Koettgen, Anna, Boer, Ian H. de, Siscovick, David S., Mozaffarian, Dariush, Wu, Jason H. Y., Ong, Kwok Leung, Marklund, Matti, Huang, Liping, Rye, Kerry-Anne, Hui, Nicholas, Pan, Xiong-Fei, Rebholz, Casey M., Kim, Hyunju, Steffen, Lyn M., Westing, Anniek C. van, Geleijnse, Johanna M., Hoogeveen, Ellen K., Chen, Yun-Yu, Chien, Kuo-Liong, Fretts, Amanda M., Lemaitre, Rozenn N., Imamura, Fumiaki, Forouhi, Nita G., Wareham, Nicholas J., Birukov, Anna, Jaeger, Susanne, Kuxhaus, Olga, Schulze, Matthias B., Mello, Vanessa Derenji de, Tuomilehto, Jaakko, Uusitupa, Matti, Lindstroem, Jaana, Tintle, Nathan, Harris, William S., Yamasaki, Keisuke, Hirakawa, Yoichiro, Ninomiya, Toshiharu, Tanaka, Toshiko, Ferrucci, Luigi, Bandinelli, Stefania, KVirtanen, Jyrki, Voutilainen, Ari, Jayasena, Tharusha, Thalamuthu, Anbupalam, Poljak, Anne, Bustamante, Sonia, Sachdev, Perminder S., Senn II, Mackenzie K, Rich, Stephen S., Tsai, Michael Y., Wood, Alexis C., Laakso, Markku, Lankinen, Maria, Yang, Xiaowei, Sun, Liang, Li, Huaixing, Lin, Xu, Nowak, Christoph, Ärnlöv, Johan, Risérus, Ulf, Lind, Lars, Le Goff, Melanie, Samieri, Cecilia, Helmer, Catherine, Qian, Frank, Micha, Renata, Tin, Adrienne, Koettgen, Anna, Boer, Ian H. de, Siscovick, David S., Mozaffarian, Dariush, and Wu, Jason H. Y.
- Abstract
OBJECTIVE: To assess the prospective associations of circulating levels of omega 3 polyunsaturated fatty acid (n-3 PUFA) biomarkers (including plant derived a linolenic acid and seafood derived eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid) with incident chronic kidney disease (CKD). DESIGN: Pooled analysis. DATA SOURCES: A consortium of 19 studies from 12 countries identified up to May 2020. STUDY SELECTION: Prospective studies with measured n-3 PUFA biomarker data and incident CKD based on estimated glomerular filtration rate. DATA EXTRACTION AND SYNTHESIS: Each participating cohort conducted de novo analysis with prespecified and consistent exposures, outcomes, covariates, and models. The results were pooled across cohorts using inverse variance weighted meta-analysis. MAIN OUTCOME MEASURES: Primary outcome of incident CKD was defined as new onset estimated glomerular filtration rate <60 mL/ min/1.73 m(2). In a sensitivity analysis, incident CKD was defined as new onset estimated glomerular filtration rate <60 mL/min/1.73 m(2) and <75% of baseline rate. RESULTS: 25 570 participants were included in the primary outcome analysis and 4944 (19.3%) developed incident CKD during follow-up (weighted median 11.3 years). In multivariable adjusted models, higher levels of total seafood n-3 PUFAs were associated with a lower incident CKD risk (relative risk per interquintile range 0.92, 95% confidence interval 0.86 to 0.98; P=0.009, I-2=9.9%). In categorical analyses, participants with total seafood n-3 PUFA level in the highest fifth had 13% lower risk of incident CKD compared with those in the lowest fifth (0.87, 0.80 to 0.96; P=0.005, I-2=0.0%). Plant derived a linolenic acid levels were not associated with incident CKD (1.00, 0.94 to 1.06; P=0.94, I-2=5.8%). Similar results were obtained in the sensitivity analysis. The association appeared consistent across subgroups by age (=60 v <60 years), estimated glomerular filtration rate (60
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- 2023
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14. Nutritional metabolism and cerebral bioenergetics in Alzheimer's disease and related dementias
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Yassine, Hussein N., Self, Wade, Kerman, Bilal E., Santoni, Giulia, Shanmugam, NandaKumar Navalpur, Abdullah, Laila, Golden, Lesley R., Fonteh, Alfred N., Harrington, Michael G., Graff, Johannes, Gibson, Gary E., Kalaria, Raj, Luchsinger, Jose A., Feldman, Howard H., Swerdlow, Russell H., Johnson, Lance A., Albensi, Benedict C., Zlokovic, Berislav V., Tanzi, Rudolph, Cunnane, Stephen, Samieri, Cecilia, Scarmeas, Nikolaos, Bowman, Gene L., Yassine, Hussein N., Self, Wade, Kerman, Bilal E., Santoni, Giulia, Shanmugam, NandaKumar Navalpur, Abdullah, Laila, Golden, Lesley R., Fonteh, Alfred N., Harrington, Michael G., Graff, Johannes, Gibson, Gary E., Kalaria, Raj, Luchsinger, Jose A., Feldman, Howard H., Swerdlow, Russell H., Johnson, Lance A., Albensi, Benedict C., Zlokovic, Berislav V., Tanzi, Rudolph, Cunnane, Stephen, Samieri, Cecilia, Scarmeas, Nikolaos, and Bowman, Gene L.
- Abstract
Disturbances in the brain's capacity to meet its energy demand increase the risk of synaptic loss, neurodegeneration, and cognitive decline. Nutritional and metabolic interventions that target metabolic pathways combined with diagnostics to identify deficits in cerebral bioenergetics may therefore offer novel therapeutic potential for Alzheimer's disease (AD) prevention and management. Many diet-derived natural bioactive components can govern cellular energy metabolism but their effects on brain aging are not clear. This review examines how nutritional metabolism can regulate brain bioenergetics and mitigate AD risk. We focus on leading mechanisms of cerebral bioenergetic breakdown in the aging brain at the cellular level, as well as the putative causes and consequences of disturbed bioenergetics, particularly at the blood-brain barrier with implications for nutrient brain delivery and nutritional interventions. Novel therapeutic nutrition approaches including diet patterns are provided, integrating studies of the gut microbiome, neuroimaging, and other biomarkers to guide future personalized nutritional interventions.
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- 2023
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15. Fatty acids in the de novo lipogenesis pathway and incidence of type 2 diabetes: A pooled analysis of prospective cohort studies
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Imamura, Fumiaki, Fretts, Amanda M., Marklund, Matti, Ardisson Korat, Andres V., Yang, Wei-Sin, Lankinen, Maria, Qureshi, Waqas, Helmer, Catherine, Chen, Tzu-An, Virtanen, Jyrki K., Wong, Kerry, Bassett, Julie K., Murphy, Rachel, Tintle, Nathan, Yu, Chaoyu Ian, Brouwer, Ingeborg A., Chien, Kuo-Liong, Chen, Yun-yu, Wood, Alexis C., del Gobbo, Liana C., Djousse, Luc, Geleijnse, Johanna M., Giles, Graham G., de Goede, Janette, Gudnason, Vilmundur, Harris, William S., Hodge, Allison, Hu, Frank, Koulman, Albert, Laakso, Markku, Lind, Lars, Lin, Hung-Ju, McKnight, Barbara, Rajaobelina, Kalina, Riserus, Ulf, Robinson, Jennifer G., Samieri, Cecilia, Senn, Mackenzie, Siscovick, David S., Soedamah-Muthu, Sabita S., Sotoodehnia, Nona, Sun, Qi, Tsai, Michael Y., Tuomainen, Tomi-Pekka, Uusitupa, Matti, Wagenknecht, Lynne E., Wareham, Nick J., Wu, Jason H. Y., Micha, Renata, Lemaitre, Rozenn N., Mozaffarian, Dariush, and Forouhi, Nita G.
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Analysis ,Fatty acids -- Analysis ,Type 2 diabetes -- Analysis ,Exercise -- Analysis ,Triglycerides -- Analysis - Abstract
Author(s): Fumiaki Imamura 1,*, Amanda M. Fretts 2, Matti Marklund 3,4,5, Andres V. Ardisson Korat 6,7, Wei-Sin Yang 8, Maria Lankinen 9, Waqas Qureshi 10, Catherine Helmer 11, Tzu-An Chen [...], Background De novo lipogenesis (DNL) is the primary metabolic pathway synthesizing fatty acids from carbohydrates, protein, or alcohol. Our aim was to examine associations of in vivo levels of selected fatty acids (16:0, 16:1n7, 18:0, 18:1n9) in DNL with incidence of type 2 diabetes (T2D). Methods and findings Seventeen cohorts from 12 countries (7 from Europe, 7 from the United States, 1 from Australia, 1 from Taiwan; baseline years = 1970-1973 to 2006-2010) conducted harmonized individual-level analyses of associations of DNL-related fatty acids with incident T2D. In total, we evaluated 65,225 participants (mean ages = 52.3-75.5 years; % women = 20.4%-62.3% in 12 cohorts recruiting both sexes) and 15,383 incident cases of T2D over the 9-year follow-up on average. Cohort-specific association of each of 16:0, 16:1n7, 18:0, and 18:1n9 with incident T2D was estimated, adjusted for demographic factors, socioeconomic characteristics, alcohol, smoking, physical activity, dyslipidemia, hypertension, menopausal status, and adiposity. Cohort-specific associations were meta-analyzed with an inverse-variance-weighted approach. Each of the 4 fatty acids positively related to incident T2D. Relative risks (RRs) per cohort-specific range between midpoints of the top and bottom quintiles of fatty acid concentrations were 1.53 (1.41-1.66; p < 0.001) for 16:0, 1.40 (1.33-1.48; p < 0.001) for 16:1n-7, 1.14 (1.05-1.22; p = 0.001) for 18:0, and 1.16 (1.07-1.25; p < 0.001) for 18:1n9. Heterogeneity was seen across cohorts (I.sup.2 = 51.1%-73.1% for each fatty acid) but not explained by lipid fractions and global geographical regions. Further adjusted for triglycerides (and 16:0 when appropriate) to evaluate associations independent of overall DNL, the associations remained significant for 16:0, 16:1n7, and 18:0 but were attenuated for 18:1n9 (RR = 1.03, 95% confidence interval (CI) = 0.94-1.13). These findings had limitations in potential reverse causation and residual confounding by imprecisely measured or unmeasured factors. Conclusions Concentrations of fatty acids in the DNL were positively associated with T2D incidence. Our findings support further work to investigate a possible role of DNL and individual fatty acids in the development of T2D.
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- 2020
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16. Abstract MP62: Fatty Acid Biomarkers of 15:0, 17:0 and Trans 16:1n-7 and Incident Coronary Heart Disease and Stroke: A Pooling Project of 15 Prospective Cohorts in the Fatty Acids and Outcomes Research Consortium
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Ardisson Korat, Andres V, primary, Qian, Frank, additional, Malik, Vasanti, additional, Lehr, Marcus, additional, Imamura, Fumiaki, additional, Tintle, Nathan, additional, Laakso, Markku, additional, van Dam, Rob, additional, Harris, William, additional, Marklund, Matti, additional, Samieri, Cecilia, additional, Senn, MacKenzie, additional, Leander, Karin, additional, Forouhi, Nita, additional, Riserus, Ulf, additional, Chien, Kou-Liong, additional, Chen, Amelia, additional, Wood, Alexis, additional, Guan, Weihua, additional, Tsai, Michael Y, additional, Murphy, Rachel, additional, Siscovick, David S, additional, Lemaitre, Rozenn, additional, Mozaffarian, Dariush, additional, and Sun, Qi, additional
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- 2023
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17. Dietary flavonoid intake at midlife and healthy aging in women
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Samieri, Cécilia, Sun, Qi, Townsend, Mary K, Rimm, Eric B, and Grodstein, Francine
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- 2014
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18. Relationship between diet and plasma long-chain n-3 PUFAs in older people: impact of apolipoprotein E genotype
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Samieri, Cécilia, Lorrain, Simon, Buaud, Benjamin, Vaysse, Carole, Berr, Claudine, Peuchant, Evelyne, Cunnane, Stephen C., and Barberger-Gateau, Pascale
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- 2013
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19. Long-Term Adherence to the Mediterranean Diet Is Associated with Overall Cognitive Status, but Not Cognitive Decline, in Women
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Samieri, Cécilia, Okereke, Olivia I., E. Devore, Elizabeth, and Grodstein, Francine
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- 2013
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20. Adherence to a Mediterranean diet and onset of disability in older persons
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Féart, Catherine, Pérès, Karine, Samieri, Cécilia, Letenneur, Luc, Dartigues, Jean-François, and Barberger-Gateau, Pascale
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- 2011
21. Diabetes Care
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QIAN, Frank, ARDISSON KORAT, Andres V., IMAMURA, Fumiaki, MARKLUND, Matti, TINTLE, Nathan, VIRTANEN, Jyrki K., ZHOU, Xia, BASSETT, Julie K., LAI, Heidi, HIRAKAWA, Yoichiro, CHIEN, Kuo-Liong, WOOD, Alexis C., LANKINEN, Maria, MURPHY, Rachel A., SAMIERI, Cecilia, PERTIWI, Kamalita, DE MELLO, Vanessa D., GUAN, Weihua, FOROUHI, Nita G., WAREHAM, Nick, HU, InterAct Consortium Frank B, RISERUS, Ulf, LIND, Lars, HARRIS, William S., SHADYAB, Aladdin H., ROBINSON, Jennifer G., STEFFEN, Lyn M., HODGE, Allison, GILES, Graham G., NINOMIYA, Toshiharu, UUSITUPA, Matti, TUOMILEHTO, Jaakko, LINDSTROM, Jaana, LAAKSO, Markku, SISCOVICK, David S., HELMER, Catherine, GELEIJNSE, Johanna M., WU, Jason H. Y., FRETTS, Amanda, LEMAITRE, Rozenn N., MICHA, Renata, MOZAFFARIAN, Dariush, SUN, Qi, FATTY, Acids, and OUTCOMES RESEARCH, Consortium
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- 2021
22. Low plasma eicosapentaenoic acid and depressive symptomatology are independent predictors of dementia risk
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Samieri, Cécilia, Féart, Catherine, Letenneur, Luc, Dartigues, Jean-François, Pérès, Karine, Auriacombe, Sophie, Peuchant, Evelyne, Delcourt, Cécile, and Barberger-Gateau, Pascale
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- 2008
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23. Plasma eicosapentaenoic acid is inversely associated with severity of depressive symptomatology in the elderly: data from the Bordeaux sample of the Three-City Study
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Féart, Catherine, Peuchant, Evelyne, Letenneur, Luc, Samieri, Cécilia, Montagnier, Delphine, Fourrier-Reglat, Annie, and Barberger-Gateau, Pascale
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- 2008
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24. Frequency of Dairy Products Consumption and 10-Year Risk of Frailty Among Older Community-Dwellers from the Three-City-Bordeaux cohort- Preliminary Results
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Rahi, Berna, Pellay, Hermine, Samieri, Cécilia, Helmer, Catherine, Dartigues, Jean-François, and Feart, Catherine
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- 2020
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25. Cadmium dietary intake and biomarker data in French high seafood consumers
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Sirot, Veronique, Samieri, Cecilia, Volatier, Jean-luc, and Leblanc, Jean-charles
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- 2008
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26. Dairy Product Intake and Long-Term Risk for Frailty among French Elderly Community Dwellers
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Rahi, Berna, primary, Pellay, Hermine, additional, Chuy, Virginie, additional, Helmer, Catherine, additional, Samieri, Cecilia, additional, and Féart, Catherine, additional
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- 2021
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27. Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies
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Harris, William S., Tintle, Nathan L., Imamura, Fumiaki, Qian, Frank, Korat, Andres V. Ardisson, Marklund, Matti, Djousse, Luc, Bassett, Julie K., Carmichael, Pierre-Hugues, Chen, Yun-Yu, Hirakawa, Yoichiro, Kupers, Leanne K., Laguzzi, Federica, Lankinen, Maria, Murphy, Rachel A., Samieri, Cecilia, Senn, Mackenzie K., Shi, Peilin, Virtanen, Jyrki K., Brouwer, Ingeborg A., Chien, Kuo-Liong, Eiriksdottir, Gudny, Forouhi, Nita G., Geleijnse, Johanna M., Giles, Graham G., Gudnason, Vilmundur, Helmer, Catherine, Hodge, Allison, Jackson, Rebecca, Khaw, Kay-Tee, Laakso, Markku, Lai, Heidi, Laurin, Danielle, Leander, Karin, Lindsay, Joan, Micha, Renata, Mursu, Jaako, Ninomiya, Toshiharu, Post, Wendy, Psaty, Bruce M., Risérus, Ulf, Robinson, Jennifer G., Shadyab, Aladdin H., Snetselaar, Linda, Sala-Vila, Aleix, Sun, Yangbo, Steffen, Lyn M., Tsai, Michael Y., Wareham, Nicholas J., Wood, Alexis C., Wu, Jason H. Y., Hu, Frank, Sun, Qi, Siscovick, David S., Lemaitre, Rozenn N., Mozaffarian, Dariush, Harris, William S., Tintle, Nathan L., Imamura, Fumiaki, Qian, Frank, Korat, Andres V. Ardisson, Marklund, Matti, Djousse, Luc, Bassett, Julie K., Carmichael, Pierre-Hugues, Chen, Yun-Yu, Hirakawa, Yoichiro, Kupers, Leanne K., Laguzzi, Federica, Lankinen, Maria, Murphy, Rachel A., Samieri, Cecilia, Senn, Mackenzie K., Shi, Peilin, Virtanen, Jyrki K., Brouwer, Ingeborg A., Chien, Kuo-Liong, Eiriksdottir, Gudny, Forouhi, Nita G., Geleijnse, Johanna M., Giles, Graham G., Gudnason, Vilmundur, Helmer, Catherine, Hodge, Allison, Jackson, Rebecca, Khaw, Kay-Tee, Laakso, Markku, Lai, Heidi, Laurin, Danielle, Leander, Karin, Lindsay, Joan, Micha, Renata, Mursu, Jaako, Ninomiya, Toshiharu, Post, Wendy, Psaty, Bruce M., Risérus, Ulf, Robinson, Jennifer G., Shadyab, Aladdin H., Snetselaar, Linda, Sala-Vila, Aleix, Sun, Yangbo, Steffen, Lyn M., Tsai, Michael Y., Wareham, Nicholas J., Wood, Alexis C., Wu, Jason H. Y., Hu, Frank, Sun, Qi, Siscovick, David S., Lemaitre, Rozenn N., and Mozaffarian, Dariush
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Associations between of omega-3 fatty acids and mortality are not clear. Here the authors report that, based on a pooled analysis of 17 prospective cohort studies, higher blood omega-3 fatty acid levels correlate with lower risk of all-cause mortality. The health effects of omega-3 fatty acids have been controversial. Here we report the results of a de novo pooled analysis conducted with data from 17 prospective cohort studies examining the associations between blood omega-3 fatty acid levels and risk for all-cause mortality. Over a median of 16 years of follow-up, 15,720 deaths occurred among 42,466 individuals. We found that, after multivariable adjustment for relevant risk factors, risk for death from all causes was significantly lower (by 15-18%, at least p < 0.003) in the highest vs the lowest quintile for circulating long chain (20-22 carbon) omega-3 fatty acids (eicosapentaenoic, docosapentaenoic, and docosahexaenoic acids). Similar relationships were seen for death from cardiovascular disease, cancer and other causes. No associations were seen with the 18-carbon omega-3, alpha-linolenic acid. These findings suggest that higher circulating levels of marine n-3 PUFA are associated with a lower risk of premature death.
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- 2021
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28. n-3 Fatty Acid Biomarkers and Incident Type 2 Diabetes : An Individual Participant-Level Pooling Project of 20 Prospective Cohort Studies
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Qian, Frank, Korat, Andres V. Ardisson, Imamura, Fumiaki, Marklund, Matti, Tintle, Nathan, Virtanen, Jyrki K., Zhou, Xia, Bassett, Julie K., Lai, Heidi, Hirakawa, Yoichiro, Chien, Kuo-Liong, Wood, Alexis C., Lankinen, Maria, Murphy, Rachel A., Samieri, Cecilia, Pertiwi, Kamalita, de Mello, Vanessa D., Guan, Weihua, Forouhi, Nita G., Wareham, Nick, Hu, Frank B., Risérus, Ulf, Lind, Lars, Harris, William S., Shadyab, Aladdin H., Robinson, Jennifer G., Steffen, Lyn M., Hodge, Allison, Giles, Graham G., Ninomiya, Toshiharu, Uusitupa, Matti, Tuomilehto, Jaakko, Lindstrom, Jaana, Laakso, Markku, Siscovick, David S., Helmer, Catherine, Geleijnse, Johanna M., Wu, Jason H. Y., Fretts, Amanda, Lemaitre, Rozenn N., Micha, Renata, Mozaffarian, Dariush, Sun, Qi, Qian, Frank, Korat, Andres V. Ardisson, Imamura, Fumiaki, Marklund, Matti, Tintle, Nathan, Virtanen, Jyrki K., Zhou, Xia, Bassett, Julie K., Lai, Heidi, Hirakawa, Yoichiro, Chien, Kuo-Liong, Wood, Alexis C., Lankinen, Maria, Murphy, Rachel A., Samieri, Cecilia, Pertiwi, Kamalita, de Mello, Vanessa D., Guan, Weihua, Forouhi, Nita G., Wareham, Nick, Hu, Frank B., Risérus, Ulf, Lind, Lars, Harris, William S., Shadyab, Aladdin H., Robinson, Jennifer G., Steffen, Lyn M., Hodge, Allison, Giles, Graham G., Ninomiya, Toshiharu, Uusitupa, Matti, Tuomilehto, Jaakko, Lindstrom, Jaana, Laakso, Markku, Siscovick, David S., Helmer, Catherine, Geleijnse, Johanna M., Wu, Jason H. Y., Fretts, Amanda, Lemaitre, Rozenn N., Micha, Renata, Mozaffarian, Dariush, and Sun, Qi
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OBJECTIVE Prospective associations between n-3 fatty acid biomarkers and type 2 diabetes (T2D) risk are not consistent in individual studies. We aimed to summarize the prospective associations of biomarkers of alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) with T2D risk through an individual participant-level pooled analysis. RESEARCH DESIGN AND METHODS For our analysis we incorporated data from a global consortium of 20 prospective studies from 14 countries. We included 65,147 participants who had blood measurements of ALA, EPA, DPA, or DHA and were free of diabetes at baseline. De novo harmonized analyses were performed in each cohort following a pre-specified protocol, and cohort-specific associations were pooled using inverse variance-weighted meta-analysis. RESULTS A total of 16,693 incident T2D cases were identified during follow-up (median follow-up ranging from 2.5 to 21.2 years). In pooled multivariable analysis, per interquintile range (difference between the 90th and 10th percentiles for each fatty acid), EPA, DPA, DHA, and their sum were associated with lower T2D incidence, with hazard ratios (HRs) and 95% CIs of 0.92 (0.87, 0.96), 0.79 (0.73, 0.85), 0.82 (0.76, 0.89), and 0.81 (0.75, 0.88), respectively (all P < 0.001). ALA was not associated with T2D (HR 0.97 [95% CI 0.92, 1.02]) per interquintile range. Associations were robust across prespecified subgroups as well as in sensitivity analyses. CONCLUSIONS Higher circulating biomarkers of seafood-derived n-3 fatty acids, including EPA, DPA, DHA, and their sum, were associated with lower risk of T2D in a global consortium of prospective studies. The biomarker of plant-derived ALA was not significantly associated with T2D risk.
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- 2021
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29. n-3 Fatty Acid Biomarkers and Incident Type 2 Diabetes: An Individual Participant-Level Pooling Project of 20 Prospective Cohort Studies
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Qian, Frank, primary, Ardisson Korat, Andres V., additional, Imamura, Fumiaki, additional, Marklund, Matti, additional, Tintle, Nathan, additional, Virtanen, Jyrki K., additional, Zhou, Xia, additional, Bassett, Julie K., additional, Lai, Heidi, additional, Hirakawa, Yoichiro, additional, Chien, Kuo-Liong, additional, Wood, Alexis C., additional, Lankinen, Maria, additional, Murphy, Rachel A., additional, Samieri, Cecilia, additional, Pertiwi, Kamalita, additional, de Mello, Vanessa D., additional, Guan, Weihua, additional, Forouhi, Nita G., additional, Wareham, Nick, additional, Hu, InterAct Consortium, Frank B., additional, Riserus, Ulf, additional, Lind, Lars, additional, Harris, William S., additional, Shadyab, Aladdin H., additional, Robinson, Jennifer G., additional, Steffen, Lyn M., additional, Hodge, Allison, additional, Giles, Graham G., additional, Ninomiya, Toshiharu, additional, Uusitupa, Matti, additional, Tuomilehto, Jaakko, additional, Lindström, Jaana, additional, Laakso, Markku, additional, Siscovick, David S., additional, Helmer, Catherine, additional, Geleijnse, Johanna M., additional, Wu, Jason H.Y., additional, Fretts, Amanda, additional, Lemaitre, Rozenn N., additional, Micha, Renata, additional, Mozaffarian, Dariush, additional, and Sun, Qi, additional
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- 2021
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30. Abstract 43: Circulating Omega-3 Fatty Acid Levels and Total and Cause-specific Mortality: Prospective Evidence From 14 Cohorts in the Fatty Acids and Outcomes Research Consortium
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Tintle, Nathan, primary, Bassett, Julie, additional, Chien, Kuo-Liong, additional, Forouhi, Nita, additional, Kupers, Leanne, additional, Lankinen, Maria, additional, Lemaitre, Rozenn, additional, Lindsay, Joan, additional, Marklund, Matti, additional, Murphy, Rachel, additional, Ninomiya, Toshiharu, additional, Robinson, Jennifer G, additional, Samieri, Cecilia, additional, Siscovick, David, additional, Virtanen, Jyrki K, additional, Wood, Alexis, additional, Mozaffarian, Dariush, additional, and Harris, William S, additional
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- 2020
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31. Abstract P414: Biomarkers of Very Long-chain Saturated Fatty Acids and Incident Coronary Heart Disease: Prospective Evidence From 15 Cohorts in the Fatty Acids and Outcomes Research Consortium
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Ardisson Korat, Andres V, primary, Qian, Frank, additional, Imamura, Fumiaki, additional, Tintle, Nathan, additional, Chen, Jiaying, additional, Van Dam, Rob M, additional, Virtanen, Jyrki K, additional, Bassett, Julie K, additional, Bartz, Traci M, additional, Hirakawa, Yoichiro, additional, Chien, Kuo-Liong, additional, Frazier-Wood, Alexis, additional, Murphy, Rachel A, additional, Samieri, Cecilia, additional, Sun, Qi, additional, Hu, Frank, additional, Wu, Jason H, additional, Micha, Renata, additional, Mozaffarian, Dariush, additional, and Lemaitre, Rozenn, additional
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- 2020
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32. High Glycemic Load Is Associated with Cognitive Decline in Apolipoprotein E epsilon4 Allele Carriers
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Gentreau, Mélissa, Raymond, Michel, Chuy, Virginie, Samieri, Cecilia, Feart, Catherine, Berticat, C., Artero, Sylvaine, Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UR226, Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), Admin, Oskar, and Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE)
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cognition ,[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,carbohydrate ,sugar ,glycemic load ,[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,apolipoprotein E4 ,diet ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition ,[SDV.NEU.SC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences ,dementia - Abstract
International audience; Recent evidence suggests that a high glycemic load (GL) diet is a risk factor for dementia, especially among apolipoprotein E ε4 allele (APOE4) carriers, while its association with cognitive decline is poorly known. Here, we investigated the association of high-GL meals with cognitive decline in older adults during a 12-year follow-up, according to their APOE4 carrier status. We used random-effect models and data from 2539 elderly participants from the Three-City study who completed a food frequency questionnaire (FFQ) to longitudinally assess the association of GL with changes in different cognitive domains (verbal fluency, visual memory, attention, visual motor processing speed, episodic memory). In APOE4 carriers, afternoon snack with high GL was significantly associated with cognitive decline in visual memory, episodic memory, and global cognition compared with APOE4 non-carriers. This study suggests a detrimental association between a high-GL diet and cognitive decline. The promotion of a low GL diet as a target to prevent cognitive decline in high-risk populations deserves more research.
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- 2020
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33. Mediterranean Diet and Incidence of Advanced Age-Related Macular Degeneration: The EYE-RISK Consortium
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MERLE, Benedicte, COLIJN, J. M., COUGNARD-GREGOIRE, Audrey, DE KONING-BACKUS, A. P. M., DELYFER, Marie-Noelle, KIEFTE-DE JONG, J. C., MEESTER-SMOOR, M., FEART, Catherine, VERZIJDEN, T., SAMIERI, Cecilia, FRANCO, O. H., KOROBELNIK, Jean-Francois, KLAVER, C. C. W., DELCOURT, Cécile, Epidemiology, and Ophthalmology
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- 2019
34. Intake of meat, fish, fruits and vegetables and long-term risk of dementia and Alzheimer's disease
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Ngabirano, Laure, Samieri, Cecilia, Feart, Catherine, Gabelle, Audrey, Artero, Sylvaine, Duflos, Claire, Berr, Claudine, Mura, Thibaut, Berr, Claudine, Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de neurologie [Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [Montpellier]-Université de Montpellier (UM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Département d'Information Médicale [CHRU Montpellier], and The 3C Study is conducted under a partnership agreement between the 'Institut National de la Santé et de la Recherche Médicale' (INSERM), the 'Victor Segalen – Bordeaux II University' and the Sanofi-Synthélabo Company. The 'Fondation pour la Recherche Médicale' funded the study preparation and initiation. The 3C Study is also supported by the 'Caisse Nationale Maladie des Travailleurs Salariés', 'Direction Générale de la Santé', Conseils Régionaux of Aquitaine, Languedoc-Roussillon and Bourgogne, Fondation de France, Ministry of ResearchINSERM Programme ‘Cohortes et collections de données biologiques’, Mutuelle Générale de l’Education Nationale, Institut de la longévité, Conseil Général de la Côte d’Or, Agence Nationale de la Recherche ANR COGINUT (PNRA/200206-01-01) and COGICARE(Longvie 2007LVIE-003-01) and Fonds de coopération scientifique Alzheimer (FCS 2009-2012).
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fish ,meat ,protopathic bias ,[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition ,[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology ,[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health ,[SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health ,Cohort ,reverse causation ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,dementia - Abstract
International audience; BACKGROUND:The links between diet and the risk of dementia have never been studied considering the possibility of protopathic bias (i.e., reverse causation).OBJECTIVE:We aimed to examine the relationship between consumption frequency of meat, fish, fruits, and vegetables and long-term risk of dementia and Alzheimer's disease (AD), by taking into account this possibility.METHODS:We analyzed data of 5,934 volunteers aged 65 and over from the Three-city study who were followed every 2 to 4 years for 12 years. Dietary habits were assessed at inclusion using a brief food frequency questionnaire. The presence of symptoms of dementia was investigated at each follow-up visit. To limit the risk of protopathic bias, a 4-year lag window between exposure and disease assessment was implemented by excluding from the analyses all dementia cases that occurred during the first four years after inclusion. Analyses were performed using a Cox proportional hazard model and were adjusted for socio-demographic, lifestyle, and health factors.RESULTS:The average follow-up time was 9.8 years. During this period, 662 cases of dementia, including 466 of AD, were identified. After adjustment, only low meat consumption (≤1 time/week) was associated with an increased risk of dementia and AD compared with regular consumption (≥4 times/week) (HR = 1.58 95% CI = [1.17-2.14], HR = 1.67 95% CI = [1.18-2.37], respectively). No association was found between the consumption of fish, raw fruits, or cooked fruits and vegetables and the risk of dementia or AD.CONCLUSION:These findings suggest very low meat consumption increases the long-term risk of dementia and AD, and that a protopathic bias could have impacted finding from previous studies.
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- 2019
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35. Diet-Related Metabolites Associated with Cognitive Decline Revealed by Untargeted Metabolomics in a Prospective Cohort
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Low, Dorrain, Lefèvre-Arbogast, Sophie, Dominguez-Gonzalez, Raúl, Urpi Sarda, Mireia, Micheau, Pierre, Pétéra, Mélanie, Centeno, Delphine, Durand, Stéphanie, Pujos-Guillot, Estelle, Korosi, Aniko, Lucassen, Paul J., Aigner, Ludwig., Proust-Lima, Cecile, Manach, Claudine, Hejblum, Boris P., Helmer, Catherine, Andres-Lacueva, Cristina, Thuret, Sandrine, Samieri, Cecilia, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Nanyang Technological University [Singapour], Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM), University of Barcelona, Instituto de Salud Carlos III [Madrid] (ISC), Plateforme Exploration du Métabolisme (PFEM), Institut National de la Recherche Agronomique (INRA)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-MetaboHUB-Clermont, MetaboHUB-MetaboHUB, University of Amsterdam [Amsterdam] (UvA), Paracelsus Medizinische Privatuniversität = Paracelsus Medical University (PMU), Statistics In System biology and Translational Medicine (SISTM), Inria Bordeaux - Sud-Ouest, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)- Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), King‘s College London, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Instituto de Salud Carlos III (ISC), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Epidémiologie et Biostatistique [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Epidémiologie et Biostatistique [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Inria Bordeaux - Sud-Ouest, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), and Structural and Functional Plasticity of the nervous system (SILS, FNWI)
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Male ,Aging ,Cognitive decline ,Coffea ,Coffee ,Eating ,Fish Products ,Metabolites ,Humans ,Metabolomics ,Cognitive Dysfunction ,Longitudinal Studies ,Research Articles ,Aged ,Aged, 80 and over ,Dietary biomarkers ,Untargeted metabolomics ,Metabòlits ,Diet ,Blood ,Case-Control Studies ,Dieta ,Dementia ,Female ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition ,Blood Chemical Analysis ,Research Article - Abstract
Scope Untargeted metabolomics may reveal preventive targets in cognitive aging, including within the food metabolome. Methods and results A case‐control study nested in the prospective Three‐City study includes participants aged ≥65 years and initially free of dementia. A total of 209 cases of cognitive decline and 209 controls (matched for age, gender, education) with slower cognitive decline over up to 12 years are contrasted. Using untargeted metabolomics and bootstrap‐enhanced penalized regression, a baseline serum signature of 22 metabolites associated with subsequent cognitive decline is identified. The signature includes three coffee metabolites, a biomarker of citrus intake, a cocoa metabolite, two metabolites putatively derived from fish and wine, three medium‐chain acylcarnitines, glycodeoxycholic acid, lysoPC(18:3), trimethyllysine, glucose, cortisol, creatinine, and arginine. Adding the 22 metabolites to a reference predictive model for cognitive decline (conditioned on age, gender, education and including ApoE‐ε4, diabetes, BMI, and number of medications) substantially increases the predictive performance: cross‐validated Area Under the Receiver Operating Curve = 75% [95% CI 70–80%] compared to 62% [95% CI 56–67%]. Conclusions The untargeted metabolomics study supports a protective role of specific foods (e.g., coffee, cocoa, fish) and various alterations in the endogenous metabolism responsive to diet in cognitive aging., The Three‐City cohort of older persons with a 12‐year follow‐up for cognition is leveraged to identify, in the serum of initially non‐demented participants, metabolites associated with subsequent cognitive decline. Untargeted metabolomics reveals a signature of 22 metabolites improving cognitive decline prediction. It includes diet‐derived metabolites (e.g., from coffee, citrus juice, cocoa, fish), as well as endogenous metabolites responsive to diet.
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- 2019
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36. Diet-Related Metabolomic Signature of Long-Term Breast Cancer Risk Using Penalized Regression: An Exploratory Study in the SU.VI.MAX Cohort
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Lécuyer, Lucie, primary, Dalle, Céline, additional, Lefevre-Arbogast, Sophie, additional, Micheau, Pierre, additional, Lyan, Bernard, additional, Rossary, Adrien, additional, Demidem, Aicha, additional, Petera, Mélanie, additional, Lagree, Marie, additional, Centeno, Delphine, additional, Galan, Pilar, additional, Hercberg, Serge, additional, Samieri, Cecilia, additional, Assi, Nada, additional, Ferrari, Pietro, additional, Viallon, Vivian, additional, Deschasaux, Mélanie, additional, Partula, Valentin, additional, Srour, Bernard, additional, Latino-Martel, Paule, additional, Kesse-Guyot, Emmanuelle, additional, Druesne-Pecollo, Nathalie, additional, Vasson, Marie-Paule, additional, Durand, Stéphanie, additional, Pujos-Guillot, Estelle, additional, Manach, Claudine, additional, and Touvier, Mathilde, additional
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- 2020
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37. Consumption of Nuts at Midlife and Healthy Aging in Women
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Freitas-Simoes, Tania-Marisa, primary, Wagner, Maude, additional, Samieri, Cecilia, additional, Sala-Vila, Aleix, additional, and Grodstein, Francine, additional
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- 2020
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38. Alzheimer's & Dementia
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JUDD, Suzanne E., BERR, Claudine, HELMER, Catherine, FÉART, Catherine, TZOURIO, Christophe, LEFEVRE-ARBOGAST, Sophie, SAMIERI, Cecilia, Bordeaux population health (BPH), and Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)
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[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,HEALTHY ,LEHA - Published
- 2018
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39. Ideal cardiovascular health, cognitive decline and risk of dementia in older persons from the community: The three-city study
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Samieri, Cecilia, PERIER, M. C., Helmer, Catherine, Berr, C., Tzourio, Christophe, Empana, J. P., Bordeaux population health (BPH), and Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)
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[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,HEALTHY ,LEHA - Published
- 2018
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40. Alzheimer's & Dementia
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Samieri, Cecilia, SONAWANE, A., Helmer, Catherine, GRODSTEIN, F., Glass, K., Bordeaux population health (BPH), and Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)
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[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,LEHA - Published
- 2018
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41. Long-term trajectories of cardiometabolic risk factors in prodromal dementia: The three-city study
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WAGNER, Maud, Helmer, Catherine, Tzourio, Christophe, Berr, C., Proust-Lima, Cécile, Samieri, Cecilia, Bordeaux population health (BPH), and Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)
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[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Biostatistics ,HEALTHY ,LEHA - Published
- 2018
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42. Early blood lipid signature predicting accelerated cognitive decline in older persons
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Lefevre-Arbogast, Sophie, Thuret, Sandrine, Helmer, Catherine, Proust-Lima, Cécile, Hejblum, Boris P., Samieri, Cecilia, Bordeaux population health (BPH), and Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)
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[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Biostatistics ,LEHA ,SISTM - Published
- 2018
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43. Re: 'modeling risk-factor trajectories when measurement tools change sequentially during follow-up in cohort studies: application to dietary habits in prodromal dementia'
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WAGNER, Maud, DARTIGUES, Jean-Francois, SAMIERI, Cecilia, PROUST-LIMA, Cecile, Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Admin, Oskar
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Epidemiology ,Feeding Behavior ,LEHA ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Risk Factors ,030220 oncology & carcinogenesis ,Humans ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Dementia ,030212 general & internal medicine ,Follow-Up Studies - Published
- 2018
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44. Associations of circulating very-long-chain saturated fatty acids and incident type 2 diabetes : a pooled analysis of prospective cohort studies
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Fretts, Amanda M., Imamura, Fumiaki, Marklund, Matti, Micha, Renata, Wu, Jason H. Y., Murphy, Rachel A., Chien, Kuo-Liong, McKnight, Barbara, Tintle, Nathan, Forouhi, Nita G., Qureshi, Waqas T., Virtanen, Jyrki K., Wong, Kerry, Wood, Alexis C., Lankinen, Maria, Rajaobelina, Kalina, Harris, Tamara B., Djousse, Luc, Harris, Bill, Wareham, Nick J., Steffen, Lyn M., Laakso, Markku, Veenstra, Jenna, Samieri, Cecilia, Brouwer, Ingeborg A., Yu, Chaoyu Ian, Koulman, Albert, Steffen, Brian T., Helmer, Catherine, Sotoodehnia, Nona, Siscovick, David, Gudnason, Vilmundur, Consortium, InterAct, Wagenknecht, Lynne, Voutilainen, Sari, Tsai, Michael Y., Uusitupa, Matti, Kalsbeek, Anya, Berr, Claudine, Mozaffarian, Dariush, Lemaitre, Rozenn N., Fretts, Amanda M., Imamura, Fumiaki, Marklund, Matti, Micha, Renata, Wu, Jason H. Y., Murphy, Rachel A., Chien, Kuo-Liong, McKnight, Barbara, Tintle, Nathan, Forouhi, Nita G., Qureshi, Waqas T., Virtanen, Jyrki K., Wong, Kerry, Wood, Alexis C., Lankinen, Maria, Rajaobelina, Kalina, Harris, Tamara B., Djousse, Luc, Harris, Bill, Wareham, Nick J., Steffen, Lyn M., Laakso, Markku, Veenstra, Jenna, Samieri, Cecilia, Brouwer, Ingeborg A., Yu, Chaoyu Ian, Koulman, Albert, Steffen, Brian T., Helmer, Catherine, Sotoodehnia, Nona, Siscovick, David, Gudnason, Vilmundur, Consortium, InterAct, Wagenknecht, Lynne, Voutilainen, Sari, Tsai, Michael Y., Uusitupa, Matti, Kalsbeek, Anya, Berr, Claudine, Mozaffarian, Dariush, and Lemaitre, Rozenn N.
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Background: Saturated fatty acids (SFAs) of different chain lengths have unique metabolic and biological effects, and a small number of recent studies suggest that higher circulating concentrations of the very-long-chain SFAs (VLSFAs) arachidic acid (20:0), behenic acid (22:0), and lignoceric acid (24:0) are associated with a lower risk of diabetes. Confirmation of these findings in a large and diverse population is needed. Objective: We investigated the associations of circulating VLSFAs 20:0, 22:0, and 24:0 with incident type 2 diabetes in prospective studies. Methods: Twelve studies that are part of the Fatty Acids and Outcomes Research Consortium participated in the analysis. Using Cox or logistic regression within studies and an inverse-variance-weighted meta-analysis across studies, we examined the associations of VLSFAs 20:0, 22:0, and 24:0 with incident diabetes among 51,431 participants. Results: There were 14,276 cases of incident diabetes across participating studies. Higher circulating concentrations of 20:0, 22:0, and 24:0 were each associated with a lower risk of incident diabetes. Pooling across cohorts, the RR (95% CI) for incident diabetes comparing the 90th percentile to the 10th percentile was 0.78 (0.70, 0.87) for 20:0, 0.84 (0.77, 0.91) for 22:0, and 0.75 (0.69, 0.83) for 24:0 after adjustment for demographic, lifestyle, adiposity, and other health factors. Results were fully attenuated in exploratory models that adjusted for circulating 16:0 and triglycerides. Conclusions: Results from this pooled analysis indicate that higher concentrations of circulating VLSFAs 20:0, 22:0, and 24:0 are each associated with a lower risk of diabetes.
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- 2019
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45. Biomarkers of Dietary Omega-6 Fatty Acids and Incident Cardiovascular Disease and Mortality : An Individual-Level Pooled Analysis of 30 Cohort Studies
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Marklund, Matti, Wu, Jason H. Y., Imamura, Fumiaki, Del Gobbo, Liana C., Fretts, Amanda, de Goede, Janette, Shi, Peilin, Tintle, Nathan, Wennberg, Maria, Aslibekyan, Stella, Chen, Tzu-An, Otto, Marcia C. de Oliveira, Hirakawa, Yoichiro, Eriksen, Helle Hojmark, Kroeger, Janine, Laguzzi, Federica, Lankinen, Maria, Murphy, Rachel A., Prem, Kiesha, Samieri, Cecilia, Virtanen, Jyrki, Wood, Alexis C., Wong, Kerry, Yang, Wei-Sin, Zhou, Xia, Baylin, Ana, Boer, Jolanda M. A., Brouwer, Ingeborg A., Campos, Hannia, Chaves, Paulo H. M., Chien, Kuo-Liong, de Faire, Ulf, Djousse, Luc, Eiriksdottir, Gudny, El-Abbadi, Naglaa, Forouhi, Nita G., Gaziano, J. Michael, Geleijnse, Johanna M., Gigante, Bruna, Giles, Graham, Guallar, Eliseo, Gudnason, Vilmundur, Harris, Tamara, Harris, William S., Helmer, Catherine, Hellenius, Mai-Lis, Hodge, Allison, Hu, Frank B., Jacques, Paul F., Jansson, Jan-Hakan, Kalsbeek, Anya, Khaw, Kay-Tee, Koh, Woon-Puay, Laakso, Markku, Leander, Karin, Lin, Hung-Ju, Lind, Lars, Luben, Robert, Luo, Juhua, McKnight, Barbara, Mursu, Jaakko, Ninomiya, Toshiharu, Overvad, Kim, Psaty, Bruce M., Rimm, Eric, Schulze, Matthias B., Siscovick, David, Nielsen, Michael Skjelbo, Smith, Albert, V, Steffen, Brian T., Steffen, Lyn, Sun, Qi, Sundström, Johan, Tsai, Michael Y., Tunstall-Pedoe, Hugh, Uusitupa, Matti I. J., van Dam, Rob M., Veenstra, Jenna, Verschuren, W. M. Monique, Wareham, Nick, Willett, Walter, Woodward, Mark, Yuan, Jian-Min, Micha, Renata, Lemaitre, Rozenn N., Mozaffarian, Dariush, Risérus, Ulf, Marklund, Matti, Wu, Jason H. Y., Imamura, Fumiaki, Del Gobbo, Liana C., Fretts, Amanda, de Goede, Janette, Shi, Peilin, Tintle, Nathan, Wennberg, Maria, Aslibekyan, Stella, Chen, Tzu-An, Otto, Marcia C. de Oliveira, Hirakawa, Yoichiro, Eriksen, Helle Hojmark, Kroeger, Janine, Laguzzi, Federica, Lankinen, Maria, Murphy, Rachel A., Prem, Kiesha, Samieri, Cecilia, Virtanen, Jyrki, Wood, Alexis C., Wong, Kerry, Yang, Wei-Sin, Zhou, Xia, Baylin, Ana, Boer, Jolanda M. A., Brouwer, Ingeborg A., Campos, Hannia, Chaves, Paulo H. M., Chien, Kuo-Liong, de Faire, Ulf, Djousse, Luc, Eiriksdottir, Gudny, El-Abbadi, Naglaa, Forouhi, Nita G., Gaziano, J. Michael, Geleijnse, Johanna M., Gigante, Bruna, Giles, Graham, Guallar, Eliseo, Gudnason, Vilmundur, Harris, Tamara, Harris, William S., Helmer, Catherine, Hellenius, Mai-Lis, Hodge, Allison, Hu, Frank B., Jacques, Paul F., Jansson, Jan-Hakan, Kalsbeek, Anya, Khaw, Kay-Tee, Koh, Woon-Puay, Laakso, Markku, Leander, Karin, Lin, Hung-Ju, Lind, Lars, Luben, Robert, Luo, Juhua, McKnight, Barbara, Mursu, Jaakko, Ninomiya, Toshiharu, Overvad, Kim, Psaty, Bruce M., Rimm, Eric, Schulze, Matthias B., Siscovick, David, Nielsen, Michael Skjelbo, Smith, Albert, V, Steffen, Brian T., Steffen, Lyn, Sun, Qi, Sundström, Johan, Tsai, Michael Y., Tunstall-Pedoe, Hugh, Uusitupa, Matti I. J., van Dam, Rob M., Veenstra, Jenna, Verschuren, W. M. Monique, Wareham, Nick, Willett, Walter, Woodward, Mark, Yuan, Jian-Min, Micha, Renata, Lemaitre, Rozenn N., Mozaffarian, Dariush, and Risérus, Ulf
- Abstract
Background: Global dietary recommendations for and cardiovascular effects of linoleic acid, the major dietary omega-6 fatty acid, and its major metabolite, arachidonic acid, remain controversial. To address this uncertainty and inform international recommendations, we evaluated how in vivo circulating and tissue levels of linoleic acid (LA) and arachidonic acid (AA) relate to incident cardiovascular disease (CVD) across multiple international studies. Methods: We performed harmonized, de novo, individual-level analyses in a global consortium of 30 prospective observational studies from 13 countries. Multivariable-adjusted associations of circulating and adipose tissue LA and AA biomarkers with incident total CVD and subtypes (coronary heart disease, ischemic stroke, cardiovascular mortality) were investigated according to a prespecified analytic plan. Levels of LA and AA, measured as the percentage of total fatty acids, were evaluated linearly according to their interquintile range (ie, the range between the midpoint of the first and fifth quintiles), and categorically by quintiles. Study-specific results were pooled using inverse-variance-weighted meta-analysis. Heterogeneity was explored by age, sex, race, diabetes mellitus, statin use, aspirin use, omega-3 levels, and fatty acid desaturase 1 genotype (when available). Results: In 30 prospective studies with medians of follow-up ranging 2.5 to 31.9 years, 15198 incident cardiovascular events occurred among 68659 participants. Higher levels of LA were significantly associated with lower risks of total CVD, cardiovascular mortality, and ischemic stroke, with hazard ratios per interquintile range of 0.93 (95% CI, 0.88-0.99), 0.78 (0.70-0.85), and 0.88 (0.79-0.98), respectively, and nonsignificantly with lower coronary heart disease risk (0.94; 0.88-1.00). Relationships were similar for LA evaluated across quintiles. AA levels were not associated with higher risk of cardiovascular outcomes; in a comparison of extreme
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- 2019
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46. Dietary patterns and risk of self-reported activity limitation in older adults from the Three-City Bordeaux Study
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Pilleron, Sophie, Peres, Karine, Jutand, Marthe-Aline, Helmer, Catherine, Dartigues, Jean-Francois, Samieri, Cecilia, FEART-COURET, Catherine, Bordeaux population health (BPH), and Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)
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[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,3C ,human activities ,SEPIA ,LEHA - Abstract
Few studies have been interested in the relationship between dietary patterns and activity limitation in older adults yet. We analysed the association between dietary patterns and the risk of self-reported activity limitation - that is mobility restriction, limitation in instrumental activities in daily living (IADL) and in activities in daily living (ADL) - in community-dwellers aged 67+ years initially free of activity limitation in 2001-2002 and re-examined at least once over 10 years - that is 583 participants for mobility restriction, 1114 for IADL limitation and 1267 for ADL limitation. At baseline, five sex-specific dietary clusters were derived by hybrid clustering method from weekly frequency of intake of twenty food and beverage items. Self-reported mobility restriction, limitations in IADL and in ADL were assessed using the Rosow-Breslau, the Lawton-Brody and the Katz scales, respectively. Associations between dietary clusters and the risk of each activity limitation were assessed using Cox proportional hazard models. In models adjusted for socio-demographic and health-related covariates, compared with the 'Healthy' cluster the 'Biscuits and snacking' cluster was associated with a higher risk of mobility restriction (hazard ratio (HR)=3.0; 95 % CI 1.6, 5.8) and limitation in IADL (HR=2.1; 95 % CI 1.1, 4.2) in men and limitation in ADL in women (HR=2.3; 95 % CI 1.3, 4.0). In this French cohort of community-dwellers aged 67+ years, some unhealthy dietary patterns may increase the risk of activity limitation all along the disablement process in older adults.
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- 2018
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47. Br J Nutr
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Pilleron, Sophie, Peres, Karine, Jutand, Marthe-Aline, Helmer, Catherine, Dartigues, Jean-Francois, Samieri, Cecilia, Feart-Couret, Catherine, Admin, Oskar, Bordeaux population health (BPH), and Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)
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[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,3C ,human activities ,SEPIA ,LEHA - Abstract
Few studies have been interested in the relationship between dietary patterns and activity limitation in older adults yet. We analysed the association between dietary patterns and the risk of self-reported activity limitation - that is mobility restriction, limitation in instrumental activities in daily living (IADL) and in activities in daily living (ADL) - in community-dwellers aged 67+ years initially free of activity limitation in 2001-2002 and re-examined at least once over 10 years - that is 583 participants for mobility restriction, 1114 for IADL limitation and 1267 for ADL limitation. At baseline, five sex-specific dietary clusters were derived by hybrid clustering method from weekly frequency of intake of twenty food and beverage items. Self-reported mobility restriction, limitations in IADL and in ADL were assessed using the Rosow-Breslau, the Lawton-Brody and the Katz scales, respectively. Associations between dietary clusters and the risk of each activity limitation were assessed using Cox proportional hazard models. In models adjusted for socio-demographic and health-related covariates, compared with the 'Healthy' cluster the 'Biscuits and snacking' cluster was associated with a higher risk of mobility restriction (hazard ratio (HR)=3.0; 95 % CI 1.6, 5.8) and limitation in IADL (HR=2.1; 95 % CI 1.1, 4.2) in men and limitation in ADL in women (HR=2.3; 95 % CI 1.3, 4.0). In this French cohort of community-dwellers aged 67+ years, some unhealthy dietary patterns may increase the risk of activity limitation all along the disablement process in older adults.
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- 2018
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48. Identification of dietary modulators of cognitive function in ageing using metabolomics discovery
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Low Yanwen, Dorrain, Lefèvre-Arbogast, Sophie, Pétéra, Mélanie, Micheau, Pierre, Centeno, Delphine, Durand, Stéphanie, Proust-Lima, Cécile, Hejblum, Boris P., Urpi Sarda, Mireia, Gonzalez-Dominguez, Raul, Andres-Lacueva, Cristina, Thuret, Sandrine, Samieri, Cecilia, Manach, Claudine, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), UMR 1219, Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Bordeaux, Nutrition and Food Science Department, University of Barcelona, Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institut, King‘s College London-King‘s College London, Centre de Recherche en Nutrition Humaine (CRNH). FRA., ProdInra, Archive Ouverte, Université de Bordeaux (UB), Unité de Nutrition Humaine - Clermont Auvergne (UNH), and Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA)
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[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition ,aliment d'origine végétale ,prévention santé ,food and beverages ,déclin cognitif ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition ,profil métabolique - Abstract
Health Break SESSION 3 Cognition and Gut-BrainHealth Break SESSION 3Cognition and Gut-Brain; Identification of dietary modulators of cognitive function in ageing using metabolomics discovery. 8. International Conference on Polyphenols and Health ICPH 2017
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- 2017
49. Fatty acid biomarkers of dairy fat consumption and incidence of type 2 diabetes : A pooled analysis of prospective cohort studies
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Imamura, Fumiaki, Fretts, Amanda, Marklund, Matti, Korat, Andres V. Ardisson, Yang, Wei-Sin, Lankinen, Maria, Qureshi, Waqas, Helmer, Catherine, Chen, Tzu-An, Wong, Kerry, Bassett, Julie K., Murphy, Rachel, Tintle, Nathan, Yu, Chaoyu Ian, Brouwer, Ingeborg A., Chien, Kuo-Liong, Frazier-Wood, Alexis C., del Gobbo, Liana C., Djousse, Luc, Geleijnse, Johanna M., Giles, Graham G., de Goede, Janette, Gudnason, Vilmundur, Harris, William S., Hodge, Allison, Hu, Frank, Koulman, Albert, Laakso, Markku, Lind, Lars, Lin, Hung-Ju, McKnight, Barbara, Rajaobelina, Kalina, Risérus, Ulf, Robinson, Jennifer G., Samieri, Cecilia, Siscovick, David S., Soedamah-Muthu, Sabita S., Sotoodehnia, Nona, Sun, Qi, Tsai, Michael Y., Uusitupa, Matti, Wagenknecht, Lynne E., Wareham, Nick J., Wu, Jason H. Y., Micha, Renata, Forouhi, Nita G., Lemaitre, Rozenn N., Mozaffarian, Dariush, Imamura, Fumiaki, Fretts, Amanda, Marklund, Matti, Korat, Andres V. Ardisson, Yang, Wei-Sin, Lankinen, Maria, Qureshi, Waqas, Helmer, Catherine, Chen, Tzu-An, Wong, Kerry, Bassett, Julie K., Murphy, Rachel, Tintle, Nathan, Yu, Chaoyu Ian, Brouwer, Ingeborg A., Chien, Kuo-Liong, Frazier-Wood, Alexis C., del Gobbo, Liana C., Djousse, Luc, Geleijnse, Johanna M., Giles, Graham G., de Goede, Janette, Gudnason, Vilmundur, Harris, William S., Hodge, Allison, Hu, Frank, Koulman, Albert, Laakso, Markku, Lind, Lars, Lin, Hung-Ju, McKnight, Barbara, Rajaobelina, Kalina, Risérus, Ulf, Robinson, Jennifer G., Samieri, Cecilia, Siscovick, David S., Soedamah-Muthu, Sabita S., Sotoodehnia, Nona, Sun, Qi, Tsai, Michael Y., Uusitupa, Matti, Wagenknecht, Lynne E., Wareham, Nick J., Wu, Jason H. Y., Micha, Renata, Forouhi, Nita G., Lemaitre, Rozenn N., and Mozaffarian, Dariush
- Abstract
Background We aimed to investigate prospective associations of circulating or adipose tissue odd-chain fatty acids 15: 0 and 17: 0 and trans-palmitoleic acid, t16:1n-7, as potential biomarkers of dairy fat intake, with incident type 2 diabetes (T2D). Methods and findings Sixteen prospective cohorts from 12 countries (7 from the United States, 7 from Europe, 1 from Australia, 1 from Taiwan) performed new harmonised individual-level analysis for the prospective associations according to a standardised plan. In total, 63,682 participants with a broad range of baseline ages and BMIs and 15,180 incident cases of T2D over the average of 9 years of follow-up were evaluated. Study-specific results were pooled using inverse-variance-weighted meta-analysis. Prespecified interactions by age, sex, BMI, and race/ethnicity were explored in each cohort and were meta-analysed. Potential heterogeneity by cohort-specific characteristics (regions, lipid compartments used for fatty acid assays) was assessed with metaregression. After adjustment for potential confounders, including measures of adiposity (BMI, waist circumference) and lipogenesis (levels of palmitate, tri-glycerides), higher levels of 15:0, 17:0, and t16:1n-7 were associated with lower incidence of T2D. In the most adjusted model, the hazard ratio (95% CI) for incident T2D per cohort-specific 10th to 90th percentile range of 15:0 was 0.80 (0.73-0.87); of 17:0, 0.65 (0.59-0.72); of t16:1n7, 0.82 (0.70-0.96); and of their sum, 0.71 (0.63-0.79). In exploratory analyses, similar associations for 15:0, 17:0, and the sum of all three fatty acids were present in both genders but stronger in women than in men ((pinteraction) < 0.001). Whereas studying associations with biomarkers has several advantages, as limitations, the biomarkers do not distinguish between different food sources of dairy fat (e.g., cheese, yogurt, milk), and residual confounding by unmeasured or imprecisely measured confounders may exist. Conclusions In a
- Published
- 2018
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50. Identification of dietary modulators of cognitive function in ageing using metabolomics discovery
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Lefèvre-Arbogast, Sophie, Pétéra, Mélanie, Micheau, Pierre, Centeno, Delphine, Durand, Stéphanie, Proust-Lima, Cécile, Hejblum, Boris, Urpi Sarda, Mireia, Gonzalez-Dominguez, Raul, Andres-Lacueva, Cristina, Thuret, Sandrine, Samieri, Cecilia, Manach, Claudine, and Low Yanwen, Dorrain
- Subjects
aliment d'origine végétale ,prévention santé ,Alimentation et Nutrition ,Food and Nutrition ,déclin cognitif ,profil métabolique - Published
- 2017
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