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1. Venoarterial Extracorporeal Membrane Oxygenation for 'Protected' Percutaneous Coronary Intervention Secondary to Refractory Polymorphic Ventricular Tachycardia and Cardiac Arrest

Author

Jordan D. Phillips, John R. Spratt, Calvin Y. Choi, Salvatore T. Scali, and Marc O. Maybauer

Subjects
extracorporeal cardiopulmonary resuscitation (ecpr), extracorporeal life support (ecls), mechanical circulatory support (mcs), protected percutaneous coronary intervention (pci), refractory polymorphic ventricular tachycardia (pvt), venoarterial extracorporeal membrane oxygenation (v-a ecmo), Anesthesiology, RD78.3-87.3, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

We present a case of cardiogenic shock secondary to refractory polymorphic ventricular tachycardia associated with coronary ischemia resulting in cardiac arrest. Following the return of spontaneous circulation, the patient was cannulated for peripheral venoarterial extracorporeal membrane oxygenation (V-A ECMO) in anticipation of high-risk “protected” percutaneous coronary intervention (PCI). Under full V-A ECMO support, inotropes and vasopressors were weaned off, and the patient underwent uneventful PCI of left circumflex and obtuse marginal lesions. After 48 hours, the patient was decannulated and could be discharged home alive 16 days after his initial cardiac arrest.

Published
2024
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2. Mitochondrial targeted catalase improves muscle strength following arteriovenous fistula creation in mice with chronic kidney disease

Author

Kyoungrae Kim, Brian Fazzone, Tomas A. Cort, Eric M. Kunz, Samuel Alvarez, Jack Moerschel, Victoria R. Palzkill, Gengfu Dong, Erik M. Anderson, Kerri A. O’Malley, Scott A. Berceli, Terence E. Ryan, and Salvatore T. Scali

Subjects
Arteriovenous fistula, Dialysis, End-stage kidney disease, Mitochondria, Medicine, Science
Abstract

Abstract Hand dysfunction is a common observation after arteriovenous fistula (AVF) creation for hemodialysis access and has a variable clinical phenotype; however, the underlying mechanism responsible is unclear. Grip strength changes are a common metric used to assess AVF-associated hand disability but has previously been found to poorly correlate with the hemodynamic perturbations post-AVF placement implicating other tissue-level factors as drivers of hand outcomes. In this study, we sought to test if expression of a mitochondrial targeted catalase (mCAT) in skeletal muscle could reduce AVF-related limb dysfunction in mice with chronic kidney disease (CKD). Male and female C57BL/6J mice were fed an adenine-supplemented diet to induce CKD prior to placement of an AVF in the iliac vascular bundle. Adeno-associated virus was used to drive expression of either a green fluorescent protein (control) or mCAT using the muscle-specific human skeletal actin (HSA) gene promoter prior to AVF creation. As expected, the muscle-specific AAV-HSA-mCAT treatment did not impact blood urea nitrogen levels (P = 0.72), body weight (P = 0.84), or central hemodynamics including infrarenal aorta and inferior vena cava diameters (P > 0.18) or velocities (P > 0.38). Hindlimb perfusion recovery and muscle capillary densities were also unaffected by AAV-HSA-mCAT treatment. In contrast to muscle mass and myofiber size which were not different between groups, both absolute and specific muscle contractile forces measured via a nerve-mediated in-situ preparation were significantly greater in AAV-HSA-mCAT treated mice (P = 0.0012 and P = 0.0002). Morphological analysis of the post-synaptic neuromuscular junction uncovered greater acetylcholine receptor cluster areas (P = 0.0094) and lower fragmentation (P = 0.0010) in AAV-HSA-mCAT treated mice. Muscle mitochondrial oxidative phosphorylation was not different between groups, but AAV-HSA-mCAT treated mice had lower succinate-fueled mitochondrial hydrogen peroxide emission compared to AAV-HSA-GFP mice (P

Published
2024
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3. Precision Medicine in Type 2 Diabetes Mellitus: Utility and Limitations

Author

Galiero R, Caturano A, Vetrano E, Monda M, Marfella R, Sardu C, Salvatore T, Rinaldi L, and Sasso FC

Subjects
type 2 diabetes mellitus, precision medicine, risk factors, genomic, environmental factors, drugs., Specialties of internal medicine, RC581-951
Abstract

Raffaele Galiero,1,* Alfredo Caturano,1,* Erica Vetrano,1 Marcellino Monda,2 Raffaele Marfella,1 Celestino Sardu,1 Teresa Salvatore,3 Luca Rinaldi,1 Ferdinando Carlo Sasso1 1Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Naples, Italy; 2Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy; 3Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy*These authors contributed equally to this workCorrespondence: Ferdinando Carlo Sasso, Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Naples, Italy, Tel/Fax +39 0815665010, Email ferdinandocarlo.sasso@unicampania.itAbstract: Type 2 diabetes mellitus (T2DM) is one of the most widespread diseases in Western countries, and its incidence is constantly increasing. Epidemiological studies have shown that in the next 20 years. The number of subjects affected by T2DM will double. In recent years, owing to the development and improvement in methods for studying the genome, several authors have evaluated the association between monogenic or polygenic genetic alterations and the development of metabolic diseases and complications. In addition, sedentary lifestyle and socio-economic and pandemic factors have a great impact on the habits of the population and have significantly contributed to the increase in the incidence of metabolic disorders, obesity, T2DM, metabolic syndrome, and liver steatosis. Moreover, patients with type 2 diabetes appear to respond to antihyperglycemic drugs. Only a minority of patients could be considered true non-responders. Thus, it appears clear that the main aim of precision medicine in T2DM is to identify patients who can benefit most from a specific drug class more than from the others. Precision medicine is a discipline that evaluates the applicability of genetic, lifestyle, and environmental factors to disease development. In particular, it evaluated whether these factors could affect the development of diseases and their complications, response to diet, lifestyle, and use of drugs. Thus, the objective is to find prevention models aimed at reducing the incidence of pathology and mortality and therapeutic personalized approaches, to obtain a greater probability of response and efficacy. This review aims to evaluate the applicability of precision medicine for T2DM, a healthcare burden in many countries.Keywords: type 2 diabetes mellitus, precision medicine, risk factors, genomic, environmental factors, drugs

Published
2023

4. Temporal serum metabolomic and lipidomic analyses distinguish patients with access-related hand disability following arteriovenous fistula creation

Author

Ram B. Khattri, Lauryn Z. Louis, Kyoungrae Kim, Erik M. Anderson, Brian Fazzone, Kenneth C. Harland, Qiongyao Hu, Kerri A. O’Malley, Scott A. Berceli, James Wymer, Terence E. Ryan, and Salvatore T. Scali

Subjects
Medicine, Science
Abstract

Abstract For end-stage kidney disease (ESKD) patients, hemodialysis requires durable vascular access which is often surgically created using an arteriovenous fistula (AVF). However, some ESKD patients that undergo AVF placement develop access-related hand dysfunction (ARHD) through unknown mechanisms. In this study, we sought to determine if changes in the serum metabolome could distinguish ESKD patients that develop ARHD from those that have normal hand function following AVF creation. Forty-five ESKD patients that underwent first-time AVF creation were included in this study. Blood samples were obtained pre-operatively and 6-weeks post-operatively and metabolites were extracted and analyzed using nuclear magnetic resonance spectroscopy. Patients underwent thorough examination of hand function at both timepoints using the following assessments: grip strength manometry, dexterity, sensation, motor and sensory nerve conduction testing, hemodynamics, and the Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaire. Nineteen of the forty-five patients displayed overt weakness using grip strength manometry (P

Published
2023
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5. Major Depressive Disorder Impacts Peripheral Artery Disease Risk Through Intermediary Risk Factors

Author

Gabrielle Shakt, Noah L. Tsao, Michael G. Levin, Venexia Walker, Rachel L. Kember, Derek Klarin, Phil Tsao, Benjamin F. Voight, Salvatore T. Scali, and Scott M. Damrauer

Subjects
major depressive disorder, Mendelian randomization, peripheral artery disease, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background Major depressive disorder (MDD) has been identified as a causal risk factor for multiple forms of cardiovascular disease. Although observational evidence has linked MDD to peripheral artery disease (PAD), causal evidence of this relationship is lacking. Methods and Results Inverse variance weighted 2‐sample Mendelian randomization was used to test the association the between genetic liability for MDD and genetic liability for PAD. Genetic liability for MDD was associated with increased genetic liability for PAD (odds ratio [OR], 1.17 [95% CI, 1.06–1.29]; P=2.6×10−3). Genetic liability for MDD was also associated with increased genetically determined lifetime smoking (β=0.11 [95% CI, 0.078–0.14]; P=1.2×10−12), decreased alcohol intake (β=−0.078 [95% CI, −0.15 to 0]; P=0.043), and increased body mass index (β=0.10 [95% CI, 0.02–0.19]; P=1.8×10−2), which in turn were associated with genetic liability for PAD (smoking: OR, 2.81 [95% CI, 2.28–3.47], P=9.8×10−22; alcohol: OR, 0.77 [95% CI, 0.66–0.88]; P=1.8×10−4; body mass index: OR, 1.61 [95% CI, 1.52–1.7]; P=1.3×10−57). Controlling for lifetime smoking index, alcohol intake, and body mass index with multivariable Mendelian randomization completely attenuated the association between genetic liability for MDD with genetic liability for PAD. Conclusions This work provides evidence for a possible causal association between MDD and PAD that is dependent on intermediate risk factors, adding to the growing body of evidence suggesting that effective management and treatment of cardiovascular diseases may require a composite of physical and mental health interventions.

Published
2024
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6. Modern management of ruptured abdominal aortic aneurysm

Author

Salvatore T. Scali and David H. Stone

Subjects
rupture, AAA, centralization, management, complications, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Ruptured abdominal aortic aneurysms (rAAA) remain one of the most clinically challenging and technically complex emergencies in contemporary vascular surgery practice. Over the past 30 years, a variety of changes surrounding the treatment of rAAA have evolved including improvements in diagnosis, development of coordinated referral networks to transfer patients more efficiently to higher volume centers, deliberate de-escalation of pre-hospital resuscitation, modification of patient and procedure selection, implementation of clinical pathways, as well as enhanced awareness of certain high-impact postoperative complications. Despite these advances, current postoperative outcomes remain sobering since morbidity and mortality rates ranging from 25%-50% persist among modern published series. Some of the most impactful variation in rAAA management has been fostered by the rapid proliferation of endovascular repair (EVAR) along with service alignment at selected centers to improve timely revascularization. Indeed, clinical care pathways and emergency response networks are now increasingly utilized which has led to improved outcomes contemporaneously. Moreover, evolution in pre- and post-operative physiologic resuscitation has also contributed to observed improvements in rAAA outcomes. Due to different developments in care provision over time, the purpose of this review is to describe the modern management of rAAA, while providing historical perspectives on patient, procedure and systems-based practice elements that have evolved care delivery paradigms in this complex group of patients.

Published
2023
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7. Influences of renal insufficiency and ischemia on mitochondrial bioenergetics and limb dysfunction in a novel murine iliac arteriovenous fistula model

Author

Erik M. Anderson, MD, Kyoungrae Kim, PhD, Brian J. Fazzone, MD, Kenneth C. Harland, BS, Qiongyao Hu, BS, Zach Salyers, MS, Victoria R. Palzkill, MS, Tomas A. Cort, BS, Eric M. Kunz, BS, Andrew J. Martin, MD, Dan Neal, MS, Kerri A. O’Malley, PhD, Scott A. Berceli, MD, PhD, Terence E. Ryan, PhD, and Salvatore T. Scali, MD

Subjects
Arteriovenous fistula, Hand dysfunction, Hemodialysis, Mitochondria, Steal syndrome, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Objective: Hand disability after hemodialysis access surgery has been common yet has remained poorly understood. Arteriovenous fistula (AVF) hemodynamic perturbations have not reliably correlated with the observed measures of hand function. Chronic kidney disease (CKD) is known to precipitate myopathy; however, the interactive influences of renal insufficiency and ischemia on limb outcomes have remained unknown. We hypothesized that CKD would contribute to access-related hand dysfunction via altered mitochondrial bioenergetics. Using a novel murine AVF model, we sought to characterize the skeletal muscle outcomes in mice with and without renal insufficiency. Methods: Male, 8-week-old C57BL/6J mice were fed either an adenine-supplemented diet to induce renal insufficiency (CKD) or a casein-based control chow (CON). After 2 weeks of dietary intervention, the mice were randomly assigned to undergo iliac AVF surgery (n = 12/group) or a sham operation (n = 5/group). Measurements of aortoiliac hemodynamics, hindlimb perfusion, and hindlimb motor function were collected for 2 weeks. The mice were sacrificed on postoperative day 14 to assess skeletal muscle histopathologic features and mitochondrial function. To assess the late outcome trends, 20 additional mice had undergone CKD induction and sham (n = 5) or AVF (n = 15) surgery and followed up for 6 weeks postoperatively before sacrifice. Results: The adenine-fed mice had had a significantly reduced glomerular filtration rate and elevated blood urea nitrogen, confirming the presence of CKD. The sham mice had a 100% survival rate and AVF cohorts an 82.1% survival rate with an 84.4% AVF patency rate. The aorta and inferior vena cava velocity measurements and the vessel diameter had increased after AVF creation (P < .0001 vs sham). The AVF groups had had a 78.4% deficit in paw perfusion compared with the contralateral limb after surgery (P < .0001 vs sham). Mitochondrial function was influenced by the presence of CKD. The respiratory capacity of the CKD-sham mice (8443 ± 1509 pmol/s/mg at maximal energy demand) was impaired compared with that of the CON-sham mice (12,870 ± 1203 pmol/s/mg; P = .0001). However, this difference was muted after AVF creation (CKD-AVF, 4478 ± 3685 pmol/s/mg; CON-AVF, 5407 ± 3582 pmol/s/mg; P = .198). The AVF cohorts had had impairments in grip strength (vs sham; P < .0001) and gait (vs sham; P = .012). However, the presence of CKD did not significantly alter the measurements of gross muscle function. The paw perfusion deficits had persisted 6 weeks postoperatively for the AVF mice (P < .0001 vs sham); however, the myopathy had resolved (grip strength, P = .092 vs sham; mitochondrial respiration, P = .108 vs sham). Conclusions: CKD and AVF-induced distal limb ischemia both impaired skeletal muscle mitochondrial function. Renal insufficiency was associated with a baseline myopathy that was exacerbated by the acute ischemic injury resulting from AVF creation. However, ischemia was the primary driver of the observed phenotype of gross motor impairment. This model reliably reproduced the local and systemic influences that contribute to access-related hand dysfunction and provides a platform for further mechanistic and therapeutic investigation. : Clinical Relevance: Access-related hand dysfunction (ARHD) has remained a common hemodialysis access surgery complication. Because of the poor mechanistic insight, the currently available therapies have been limited to surgical remediation of the hemodynamic changes in the limb for only the most severe clinical manifestations. Furthermore, expectant management or access revision will not be ideal options, especially for patients with mild to moderate ARHD, owing to the perioperative risk and implications for long-term access durability. Therefore, skeletal muscle mitochondrial-based therapy represents an intriguing treatment strategy. However, the characteristics of mitochondrial function after arteriovenous fistula placement are unknown. In the present study, we have characterized the ischemic and uremic influences on skeletal muscle physiology to identify the pathogenic drivers of ARHD.

Published
2022
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8. S100A8 and S100A9 are elevated in chronically threatened ischemic limb muscle and induce ischemic mitochondrial pathology in mice

Author

Zachary R. Salyers, MS, Vinicius Mariani, MS, Nicholas Balestrieri, MS, Ravi A. Kumar, MS, Nicholas A. Vugman, Trace Thome, MS, Katelyn R. Villani, MS, Scott A. Berceli, MD, PhD, Salvatore T. Scali, MD, Georgios Vasilakos, PhD, and Terence E. Ryan, PhD

Subjects
Inflammation, Mitochondria, Peripheral artery disease, Vascular disease, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Objective: The objective of the present study was to determine whether elevated levels of S100A8 and S100A9 (S100A8/A9) alarmins contribute to ischemic limb pathology. Methods: Gastrocnemius muscle was collected from control patients without peripheral arterial disease (PAD; n = 14) and patients with chronic limb threatening limb ischemia (CLTI; n = 14). Mitochondrial function was assessed in permeabilized muscle fibers, and RNA and protein analyses were used to quantify the S100A8/A9 levels. Additionally, a mouse model of hindlimb ischemia with and without exogenous delivery of S100A8/A9 was used. Results: Compared with the non-PAD control muscles, CLTI muscles displayed significant increases in the abundance of S100A8 and S100A9 at both mRNA and protein levels (P < .01). The CLTI muscles also displayed significant impairment in mitochondrial oxidative phosphorylation and increased mitochondrial hydrogen peroxide production compared with the non-PAD controls. The S100A8/A9 levels correlated significantly with the degree of muscle mitochondrial dysfunction (P < .05 for all). C57BL6J mice treated with recombinant S100A8/A9 displayed impaired perfusion recovery and muscle mitochondrial impairment compared with the placebo-treated mice after hindlimb ischemia surgery. These mitochondrial deficits observed after S100A8/A9 treatment were confirmed in the muscle cell culture system under normoxic conditions. Conclusions: The S100A8/A9 levels were increased in CLTI limb muscle specimens compared with the non-PAD control muscle specimens, and the level of accumulation was associated with muscle mitochondrial impairment. Elevated S100A8/A9 levels in mice subjected to hindlimb ischemia impaired perfusion recovery and mitochondrial function. Together, these findings suggest that the inflammatory mediators S100A8/A9 might be directly involved in ischemic limb pathology. : Clinical Relevance: Despite improvements in the surgical management of chronic limb threatening limb ischemia (CLTI), the rates of major adverse limb events have remained high. Skeletal muscle has emerged as a strong predictor of outcomes in peripheral arterial disease (PAD)/CLTI; however, a complete understanding of muscle pathology in CLTI is lacking. This study identified elevated S100A8 and S100A9 alarmin proteins as a characteristic of CLTI muscle specimens and that the S100A8/A9 levels are associated with the degree of mitochondrial impairment in patient limb muscle specimens. Using a mouse model of PAD, treatment with S100A8/A9 exacerbated ischemic limb pathology, including impaired limb perfusion recovery and muscle mitochondrial impairment. Taken together, these findings connect the inflammatory milieu in the CLTI limb to exacerbated limb muscle outcomes via mitochondrial alterations.

Published
2022
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9. Development of a murine iliac arteriovenous fistula model for examination of hemodialysis access-related limb pathophysiology

Author

Kyoungrae Kim, PhD, Erik M. Anderson, MD, Andrew J. Martin, MD, Qiongyao Hu, BS, Tomas A. Cort, BS, Kenneth C. Harland, BS, Kerri A. O'Malley, PhD, Guanyi Lu, MD, PhD, Scott A. Berceli, MD, PhD, Terence E. Ryan, PhD, and Salvatore T. Scali, MD

Subjects
Arteriovenous fistula, Hand dysfunction, Hemodialysis, Mitochondria, Venous hypertension, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Objective: Hemodialysis access-related hand dysfunction is a common clinical feature of patients with chronic kidney disease (CKD) after arteriovenous fistula (AVF) placement. The heterogeneity in symptoms and the lack of a predictive association with changes in hemodynamic alterations precipitated by the AVF suggest that other factors are involved in the mechanisms responsible for causing hand and limb dysfunction postoperatively. To the best of our knowledge, no suitable animal models have provided a platform for performing preclinical experiments designed to elucidate the biologic drivers of access-related hand dysfunction. Therefore, our objective was to develop a novel murine AVF model that could be used to study dialysis access-related limb dysfunction. Methods: Male 8-week-old C57BL/6J mice (n = 15/group) were exposed to either an adenine-supplemented diet to induce CKD or casein-based chow (control). Four weeks after the diet intervention, the mice were randomly assigned to receive an iliac AVF (n = 10/group) or sham surgery (n = 5/group) on the left hindlimb. The mice were sacrificed 2 weeks after surgery, and AVF specimens and hindlimb skeletal muscles were collected for further analysis. Results: Before AVF or sham surgery, the glomerular filtration rates were significantly reduced and the blood urea nitrogen levels were significantly elevated in the CKD groups compared with the controls (P < .05). AVF surgery was associated with an ∼80% patency rate among the survivors (four control and three CKD mice died postoperatively). Patency was verified by changes in hemodynamics using Doppler ultrasound imaging and altered histologic morphology. Compared with sham surgery, AVF surgery reduced ipsilateral hindlimb perfusion to the tibialis anterior muscle (20%-40%) and paw (40%-50%), which remained stable until euthanasia. Analysis of gastrocnemius muscle mitochondrial respiratory function uncovered a significant decrease (40%-50%) in mitochondrial function in the AVF mice. No changes were found in the muscle mass, myofiber cross-sectional area, or centrally nucleated fiber proportion in the extensor digitorum longus and soleus muscles between the sham and AVF mice. Conclusions: The results from the present study have demonstrated that iliac AVF formation is a practical animal model that facilitates examination of hemodialysis access-related limb dysfunction. AVF surgery produced the expected hemodynamic changes, and evaluation of the limb muscle revealed a substantial mitochondrial impairment that was present without changes in muscle size. : Clinical Relevance: Autogenous arteriovenous fistula creation remains the preferred vascular access option for patients requiring chronic hemodialysis therapy. However, access-related hand dysfunction (ARHD) remains highly prevalent in this population. Clinical management of the disability is difficult because of symptom heterogeneity and limited treatment options. Additionally, the current preclinical models do not adequately replicate the pathologic condition to allow for investigation of underlying mechanisms and to test new therapies. Therefore, medical progress has been marginal. In the present study, we have outlined a novel murine model to study ARHD and described the associated mitochondrial impairments, providing a unique tool for preclinical therapeutic development.

Published
2021
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10. Interventional‐ and amputation‐stage muscle proteomes in the chronically threatened ischemic limb

Author

Terence E. Ryan, Kyoungrae Kim, Salvatore T. Scali, Scott A. Berceli, Trace Thome, Zachary R. Salyers, Kerri A. O'Malley, Thomas D. Green, Reema Karnekar, Kelsey H. Fisher‐Wellman, Dean J. Yamaguchi, and Joseph M. McClung

Subjects
metabolism, peripheral artery disease, surgery, vascular disease, Medicine (General), R5-920
Abstract

Abstract Background Despite improved surgical approaches for chronic limb‐threatening ischemia (CLTI), amputation rates remain high and contributing tissue‐level factors remain unknown. The purpose of this study was twofold: (1) to identify differences between the healthy adult and CLTI limb muscle proteome, and (2) to identify differences in the limb muscle proteome of CLTI patients prior to surgical intervention or at the time of amputation. Methods and results Gastrocnemius muscle was collected from non‐ischemic controls (n = 19) and either pre‐interventional surgery (n = 10) or at amputation outcome (n = 29) CLTI patients. All samples were subjected to isobaric tandem‐mass‐tag‐assisted proteomics. The mitochondrion was the primary classification of downregulated proteins (> 70%) in CLTI limb muscles and paralleled robust functional mitochondrial impairment. Upregulated proteins (> 38%) were largely from the extracellular matrix. Across the two independent sites, 39 proteins were downregulated and 12 upregulated uniformly. Pre‐interventional CLTI muscles revealed a robust upregulation of mitochondrial proteins but modest functional impairments in fatty acid oxidation as compared with controls. Comparison of pre‐intervention and amputation CLTI limb muscles revealed mitochondrial proteome and functional deficits similar to that between amputation and non‐ischemic controls. Interestingly, these observed changes occurred despite 62% of the amputation CLTI patients having undergone a prior surgical intervention. Conclusions The CLTI proteome supports failing mitochondria as a phenotype that is unique to amputation outcomes. The signature of pre‐intervention CLTI muscle reveals stable mitochondrial protein abundance that is insufficient to uniformly prevent functional impairments. Taken together, these findings support the need for future longitudinal investigations aimed to determine whether mitochondrial failure is causally involved in amputation outcomes from CLTI.

Published
2022
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11. Impaired muscle mitochondrial energetics is associated with uremic metabolite accumulation in chronic kidney disease

Author

Trace Thome, Ravi A. Kumar, Sarah K. Burke, Ram B. Khattri, Zachary R. Salyers, Rachel C. Kelley, Madeline D. Coleman, Demetra D. Christou, Russell T. Hepple, Salvatore T. Scali, Leonardo F. Ferreira, and Terence E. Ryan

Subjects
Muscle biology, Nephrology, Medicine
Abstract

Chronic kidney disease (CKD) causes progressive skeletal myopathy involving atrophy, weakness, and fatigue. Mitochondria have been thought to contribute to skeletal myopathy; however, the molecular mechanisms underlying muscle metabolism changes in CKD are unknown. We employed a comprehensive mitochondrial phenotyping platform to elucidate the mechanisms of skeletal muscle mitochondrial impairment in mice with adenine-induced CKD. CKD mice displayed significant reductions in mitochondrial oxidative phosphorylation (OXPHOS), which was strongly correlated with glomerular filtration rate, suggesting a link between kidney function and muscle mitochondrial health. Biochemical assays uncovered that OXPHOS dysfunction was driven by reduced activity of matrix dehydrogenases. Untargeted metabolomics analyses in skeletal muscle revealed a distinct metabolite profile in CKD muscle including accumulation of uremic toxins that strongly associated with the degree of mitochondrial impairment. Additional muscle phenotyping found CKD mice experienced muscle atrophy and increased muscle protein degradation, but only male CKD mice had lower maximal contractile force. CKD mice had morphological changes indicative of destabilization in the neuromuscular junction. This study provides the first comprehensive evaluation of mitochondrial health in murine CKD muscle to our knowledge and uncovers several unknown uremic metabolites that strongly associate with the degree of mitochondrial impairment.

Published
2021
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13. The Spectrum of Hand Dysfunction After Hemodialysis Fistula Placement

Author

Jonathan P. Rehfuss, Scott A. Berceli, Sarah M. Barbey, Yong He, Paul S. Kubilis, Adam W. Beck, Thomas S. Huber, and Salvatore T. Scali

Subjects
arteriovenous fistula, hand dysfunction, hemodialysis access, vascular access steal syndrome, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Contemporary dogma has classically attributed hand dysfunction following hemodialysis arteriovenous fistula (AVF) placement to regional ischemia. We hypothesize that hemodynamic perturbations alone do not entirely explain the postoperative changes in hand function and, furthermore, that various elements of hand function are differentially affected following surgery. Methods: Bilateral wrist and digital pressures and upper extremity nerve conduction tests were recorded preoperatively and at 6 weeks and 6 months following upper extremity AVF construction in 46 patients. Concurrently, biomechanical tests were administered to evaluate multiple limb functional domains, including grip strength, dexterity, sensation, and perception of hand function. Results: Mean participant age was 59 ± 14 years (75% male), and 48% were on hemodialysis at the time of access placement. Of the participants, 69% had a brachial-based AVF, and the remainder had radial-based accesses. Six weeks following AVF placement, a significant decrease in access-side digital pressures was observed, with only partial recovery at 6 months (P < 0.0001). Grip strength was significantly worse in the access-side limb (P = 0.0003), and the Disability of Arm, Shoulder and Hand (DASH) questionnaire score substantially worsened postoperatively (P = 0.06). Digital sensation and limb dexterity did not differ between limb sides (P > 0.1) or change significantly over time (P > 0.1). Principal component analyses demonstrated that nerve conduction parameters tended to track the biomechanical parameters, yet both were relatively independent of the hemodynamic parameters. Discussion: Our findings suggest that ischemia alone does not completely explain access-related hand dysfunction and that future study is needed to elucidate alternative mechanisms.

Published
2017
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16. Skeletal Muscle Mitochondrial Dysfunction and Oxidative Stress in Peripheral Arterial Disease: A Unifying Mechanism and Therapeutic Target

Author

Kyoungrae Kim, Erik M. Anderson, Salvatore T. Scali, and Terence E. Ryan

Subjects
myopathy, peripheral vascular disease, bioenergetics, ischemia, reactive oxygen species, Therapeutics. Pharmacology, RM1-950
Abstract

Peripheral artery disease (PAD) is caused by atherosclerosis in the lower extremities, which leads to a spectrum of life-altering symptomatology, including claudication, ischemic rest pain, and gangrene requiring limb amputation. Current treatments for PAD are focused primarily on re-establishing blood flow to the ischemic tissue, implying that blood flow is the decisive factor that determines whether or not the tissue survives. Unfortunately, failure rates of endovascular and revascularization procedures remain unacceptably high and numerous cell- and gene-based vascular therapies have failed to demonstrate efficacy in clinical trials. The low success of vascular-focused therapies implies that non-vascular tissues, such as skeletal muscle and oxidative stress, may substantially contribute to PAD pathobiology. Clues toward the importance of skeletal muscle in PAD pathobiology stem from clinical observations that muscle function is a strong predictor of mortality. Mitochondrial impairments in muscle have been documented in PAD patients, although its potential role in clinical pathology is incompletely understood. In this review, we discuss the underlying mechanisms causing mitochondrial dysfunction in ischemic skeletal muscle, including causal evidence in rodent studies, and highlight emerging mitochondrial-targeted therapies that have potential to improve PAD outcomes. Particularly, we will analyze literature data on reactive oxygen species production and potential counteracting endogenous and exogenous antioxidants.

Published
2020
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17. Sequential and Simultaneous Immunization of Rabbits with HIV-1 Envelope Glycoprotein SOSIP.664 Trimers from Clades A, B and C.

Author

P J Klasse, Celia C LaBranche, Thomas J Ketas, Gabriel Ozorowski, Albert Cupo, Pavel Pugach, Rajesh P Ringe, Michael Golabek, Marit J van Gils, Miklos Guttman, Kelly K Lee, Ian A Wilson, Salvatore T Butera, Andrew B Ward, David C Montefiori, Rogier W Sanders, and John P Moore

Subjects
Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5
Abstract

We have investigated the immunogenicity in rabbits of native-like, soluble, recombinant SOSIP.664 trimers based on the env genes of four isolates of human immunodeficiency virus type 1 (HIV-1); specifically BG505 (clade A), B41 (clade B), CZA97 (clade C) and DU422 (clade C). The various trimers were delivered either simultaneously (as a mixture of clade A + B trimers) or sequentially over a 73-week period. Autologous, Tier-2 neutralizing antibody (NAb) responses were generated to the clade A and clade B trimers in the bivalent mixture. When delivered as boosting immunogens to rabbits immunized with the clade A and/or clade B trimers, the clade C trimers also generated autologous Tier-2 NAb responses, the CZA97 trimers doing so more strongly and consistently than the DU422 trimers. The clade C trimers also cross-boosted the pre-existing NAb responses to clade A and B trimers. We observed heterologous Tier-2 NAb responses albeit inconsistently, and with limited overall breath. However, cross-neutralization of the clade A BG505.T332N virus was consistently observed in rabbits immunized only with clade B trimers and then boosted with clade C trimers. The autologous NAbs induced by the BG505, B41 and CZA97 trimers predominantly recognized specific holes in the glycan shields of the cognate virus. The shared location of some of these holes may account for the observed cross-boosting effects and the heterologous neutralization of the BG505.T332N virus. These findings will guide the design of further experiments to determine whether and how multiple Env trimers can together induce more broadly neutralizing antibody responses.

Published
2016
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18. A20 modulates lipid metabolism and energy production to promote liver regeneration.

Author

Scott M Damrauer, Peter Studer, Cleide G da Silva, Christopher R Longo, Haley E Ramsey, Eva Csizmadia, Gautam V Shrikhande, Salvatore T Scali, Towia A Libermann, Manoj K Bhasin, and Christiane Ferran

Subjects
Medicine, Science
Abstract

Liver regeneration is clinically of major importance in the setting of liver injury, resection or transplantation. We have demonstrated that the NF-κB inhibitory protein A20 significantly improves recovery of liver function and mass following extended liver resection (LR) in mice. In this study, we explored the Systems Biology modulated by A20 following extended LR in mice.We performed transcriptional profiling using Affymetrix-Mouse 430.2 arrays on liver mRNA retrieved from recombinant adenovirus A20 (rAd.A20) and rAd.βgalactosidase treated livers, before and 24 hours after 78% LR. A20 overexpression impacted 1595 genes that were enriched for biological processes related to inflammatory and immune responses, cellular proliferation, energy production, oxidoreductase activity, and lipid and fatty acid metabolism. These pathways were modulated by A20 in a manner that favored decreased inflammation, heightened proliferation, and optimized metabolic control and energy production. Promoter analysis identified several transcriptional factors that implemented the effects of A20, including NF-κB, CEBPA, OCT-1, OCT-4 and EGR1. Interactive scale-free network analysis captured the key genes that delivered the specific functions of A20. Most of these genes were affected at basal level and after resection. We validated a number of A20's target genes by real-time PCR, including p21, the mitochondrial solute carriers SLC25a10 and SLC25a13, and the fatty acid metabolism regulator, peroxisome proliferator activated receptor alpha. This resulted in greater energy production in A20-expressing livers following LR, as demonstrated by increased enzymatic activity of cytochrome c oxidase, or mitochondrial complex IV.This Systems Biology-based analysis unravels novel mechanisms supporting the pro-regenerative function of A20 in the liver, by optimizing energy production through improved lipid/fatty acid metabolism, and down-regulated inflammation. These findings support pursuit of A20-based therapies to improve patients' outcomes in the context of extreme liver injury and extensive LR for tumor treatment or donation.

Published
2011
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19. O-glycosylation regulates ubiquitination and degradation of the anti-inflammatory protein A20 to accelerate atherosclerosis in diabetic ApoE-null mice.

Author

Gautam V Shrikhande, Salvatore T Scali, Cleide G da Silva, Scott M Damrauer, Eva Csizmadia, Prabhakar Putheti, Michaela Matthey, Roy Arjoon, Rakesh Patel, Jeffrey J Siracuse, Elizabeth R Maccariello, Nicholas D Andersen, Thomas Monahan, Clayton Peterson, Sanah Essayagh, Peter Studer, Renata Padilha Guedes, Olivier Kocher, Anny Usheva, Aristidis Veves, Elzbieta Kaczmarek, and Christiane Ferran

Subjects
Medicine, Science
Abstract

Accelerated atherosclerosis is the leading cause of morbidity and mortality in diabetic patients. Hyperglycemia is a recognized independent risk factor for heightened atherogenesis in diabetes mellitus (DM). However, our understanding of the mechanisms underlying glucose damage to the vasculature remains incomplete.High glucose and hyperglycemia reduced upregulation of the NF-κB inhibitory and atheroprotective protein A20 in human coronary endothelial (EC) and smooth muscle cell (SMC) cultures challenged with Tumor Necrosis Factor alpha (TNF), aortae of diabetic mice following Lipopolysaccharide (LPS) injection used as an inflammatory insult and in failed vein-grafts of diabetic patients. Decreased vascular expression of A20 did not relate to defective transcription, as A20 mRNA levels were similar or even higher in EC/SMC cultured in high glucose, in vessels of diabetic C57BL/6 and FBV/N mice, and in failed vein grafts of diabetic patients, when compared to controls. Rather, decreased A20 expression correlated with post-translational O-Glucosamine-N-Acetylation (O-GlcNAcylation) and ubiquitination of A20, targeting it for proteasomal degradation. Restoring A20 levels by inhibiting O-GlcNAcylation, blocking proteasome activity, or overexpressing A20, blocked upregulation of the receptor for advanced glycation end-products (RAGE) and phosphorylation of PKCβII, two prime atherogenic signals triggered by high glucose in EC/SMC. A20 gene transfer to the aortic arch of diabetic ApoE null mice that develop accelerated atherosclerosis, attenuated vascular expression of RAGE and phospho-PKCβII, significantly reducing atherosclerosis.High glucose/hyperglycemia regulate vascular A20 expression via O-GlcNAcylation-dependent ubiquitination and proteasomal degradation. This could be key to the pathogenesis of accelerated atherosclerosis in diabetes.

Published
2010
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27. Editor's Choice – Variation in Intact Abdominal Aortic Aneurysm Repair Outcomes by Country: Analysis of International Consortium of Vascular Registries 2010 – 2016

Author

Boyle, Jonathan R., Mao, Jialin, Beck, Adam W., Venermo, Maarit, Sedrakyan, Art, Behrendt, Christian-Alexander, Szeberin, Zoltan, Eldrup, Nikolaj, Schermerhorn, Marc, Beiles, Barry, Thomson, Ian, Cassar, Kevin, Altreuther, Martin, Debus, Sebastian, Johal, Amundeep S., Waton, Sam, Scali, Salvatore T., Cromwell, David A., and Mani, Kevin

Published
2021
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28. Editor's Choice – Optimal Threshold for the Volume–Outcome Relationship After Open AAA Repair in the Endovascular Era: Analysis of the International Consortium of Vascular Registries

Author

Scali, Salvatore T., Beck, Adam, Sedrakyan, Art, Mao, Jialin, Behrendt, Christian-Alexander, Boyle, Jonathan R., Venermo, Maarit, Faizer, Rumi, Schermerhorn, Marc, Beiles, Barry, Szeberin, Zoltan, Eldrup, Nikolaj, Thomson, Ian, Cassar, Kevin, Altreuther, Martin, Debus, Sebastian, Johal, Amundeep, Bjorck, Martin, Cronenwett, Jack L., and Mani, Kevin

Published
2021
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36. Antihypertensive treatment changes and related clinical outcomes in older hospitalized patients

Author

Cicco, S, D'Abbondanza, M, Proietti, M, Zaccone, V, Pes, C, Caradio, F, Mattioli, M, Piano, S, Marra, A, Nobili, A, Mannucci, P, Pietrangelo, A, Sesti, G, Buzzetti, E, Salzano, A, Cimellaro, A, Perticone, F, Violi, F, Corazza, G, Corrao, S, Marengoni, A, Salerno, F, Cesari, M, Tettamanti, M, Pasina, L, Franchi, C, Novella, A, Miglio, G, Galbussera, A, Ardoino, I, Prisco, D, Silvestri, E, Emmi, G, Bettiol, A, Mattioli, I, Biolo, G, Zanetti, M, Bartelloni, G, Zaccari, M, Chiuch, M, Vanoli, M, Grignani, G, Pulixi, E, Pirro, M, Lupattelli, G, Bianconi, V, Alcidi, R, Giotta, A, Mannarino, M, Girelli, D, Busti, F, Marchi, G, Barbagallo, M, Dominguez, L, Beneduce, V, Cacioppo, F, Natoli, G, Mularo, S, Raspanti, M, Argano, C, Cavallaro, F, Zoli, M, Matacena, M, Orio, G, Magnolfi, E, Serafini, G, Simili, A, Brunori, M, Lazzari, I, Cappellini, M, Fabio, G, De Amicis, M, De Luca, G, Scaramellini, N, Di Stefano, V, Leoni, S, Seghezzi, S, Di Mauro, A, Maira, D, Mancarella, M, Lucchi, T, Rossi, P, Clerici, M, Bonini, G, Conti, F, Prolo, S, Fabrizi, M, Martelengo, M, Vigani, G, Di Sabatino, A, Miceli, E, Lenti, M, Pisati, M, Pitotti, L, Padula, D, Antoci, V, Cambie, G, Pontremoli, R, Beccati, V, Nobili, G, Leoncini, G, Alberto, J, Cattaneo, F, Anastasio, L, Sofia, L, Carbone, M, Cipollone, F, Guagnano, M, Rossi, I, Valeriani, E, D'Ardes, D, Esposito, L, Sestili, S, Angelucci, E, Mancuso, G, Calipari, D, Bartone, M, Delitala, G, Berria, M, Delitala, A, Muscaritoli, M, Molfino, A, Petrillo, E, Giorgi, A, Gracin, C, Imbimbo, G, Zuccala, G, D'Aurizio, G, Romanelli, G, Volpini, A, Lucente, D, Manzoni, F, Pirozzi, A, Zucchelli, A, Picardi, A, Gentilucci, U, Gallo, P, Dell'Unto, C, Bellelli, G, Corsi, M, Antonucci, C, Sidoli, C, Principato, G, Bonfanti, A, Szabo, H, Mazzola, P, Piazzoli, A, Arturi, F, Succurro, E, Tassone, B, Giofre, F, Serra, M, Bleve, M, Brucato, A, De Falco, T, Negro, E, Brenna, M, Trotta, L, Squintani, G, Randi, M, Fabris, F, Bertozzi, I, Bogoni, G, Rabuini, M, Prandini, T, Ratti, F, Zurlo, C, Cerruti, L, Cosi, E, Manfredini, R, Fabbian, F, Boari, B, De Giorgi, A, Tiseo, R, Paolisso, G, Rizzo, M, Catalano, C, Di Meo, I, Borghi, C, Strocchi, E, Ianniello, E, Soldati, M, Schiavone, S, Bragagni, A, Leoni, F, De Sando, V, Scarduelli, S, Cammarosano, M, Pareo, I, Sabba, C, Vella, F, Suppressa, P, De Vincenzo, G, Comitangelo, A, Amoruso, E, Custodero, C, Re, G, Schilardi, A, Loparco, F, Fenoglio, L, Falcetta, A, Giraudo, A, D'Aniano, S, Fracanzani, A, Tiraboschi, S, Cespiati, A, Oberti, G, Sigon, G, Cinque, F, Peyvandi, F, Rossio, R, Colombo, G, Agosti, P, Pagliaro, E, Semproni, E, Ciro, C, Monzani, V, Savojardo, V, Ceriani, G, Folli, C, Pallini, G, Montecucco, F, Ottonello, L, Caserza, L, Vischi, G, Kassem, S, Liberale, L, Liberato, N, Tognin, T, Purrello, F, Di Pino, A, Piro, S, Rozzini, R, Falanga, L, Pisciotta, M, Bellucci, F, Buffelli, S, Ferrandina, C, Mazzeo, F, Spazzini, E, Cono, G, Cesaroni, G, Montrucchio, G, Peasso, P, Favale, E, Poletto, C, Margaria, C, Sanino, M, Perri, L, Guasti, L, Rotunno, F, Castiglioni, L, Maresca, A, Squizzato, A, Campiotti, L, Grossi, A, Diprizio, R, Dentali, F, Bertolotti, M, Mussi, C, Lancellotti, G, Libbra, M, Galassi, M, Grassi, Y, Greco, A, Bigi, E, Pellegrini, E, Orlandi, L, Dondi, G, Carulli, L, Sciacqua, A, Perticone, M, Battaglia, R, Maio, R, Scozzafava, A, Condoleo, V, Falbo, T, Colangelo, L, Filice, M, Clausi, E, Stanghellini, V, Ruggeri, E, del Vecchio, S, Benzoni, I, Salvi, A, Leonardi, R, Damiani, G, Moroncini, G, Capeci, W, Martino, G, Biondi, L, Pettinari, P, Ormas, M, Filippini, E, Benfaremo, D, Romiti, R, Ghio, R, Col, A, Minisola, S, Cilli, M, Labbadia, G, Afeltra, A, Marigliano, B, Pipita, M, Castellino, P, Zanoli, L, Gennaro, A, Gaudio, A, Pignataro, S, Mete, F, Gino, M, Moreo, G, Pina, G, Ballestrero, A, Ferrando, F, Gonella, R, Cerminara, D, Setti, P, Traversa, C, Scarsi, C, Graziella, B, Baldassarre, S, Fragapani, S, Gruden, G, Berti, F, Famularo, G, Tarsitani, P, Castello, R, Pasino, M, Maggio, M, Ceda, G, Morganti, S, Artoni, A, Grossi, M, Del Giacco, S, Firinu, D, Costanzo, G, Argiolas, G, Paoletti, G, Losa, F, Montalto, G, Licata, A, Montalto, F, Corica, F, Basile, G, Catalano, A, Bellone, F, Principato, C, Malatino, L, Stancanelli, B, Terranova, V, Di Marca, S, Di Quattro, R, La Malfa, L, Caruso, R, Mecocci, P, Ruggiero, C, Boccardi, V, Meschi, T, Ticinesi, A, Nouvenne, A, Minuz, P, Fondrieschi, L, Imperiale, G, Morellini, S, Pirisi, M, Fra, G, Sola, D, Bellan, M, Quadri, R, Larovere, E, Novelli, M, Simeone, E, Scurti, R, Tolloso, F, Tarquini, R, Valoriani, A, Dolenti, S, Vannini, G, Volpi, R, Bocchi, P, Vignali, A, Harari, S, Lonati, C, Napoli, F, Aiello, I, Salvatore, T, Monaco, L, Ricozzi, C, Pilotto, A, Indiano, I, Gandolfo, F, Pasini, F, Capecchi, P, Nuti, R, Valenti, R, Ruvio, M, Cappelli, S, Palazzuoli, A, Bernardi, M, Bassi, S, Santi, L, Zaccherini, G, Durante, V, Tirotta, D, Eusebi, G, Cattaneo, M, Amoruso, M, Fracasso, P, Fasolino, C, Tresoldi, M, Bozzolo, E, Damanti, S, Porta, M, Armentaro, G, Arnone, M, Barone, M, Bertolino, L, Bianco, S, Binello, N, Brancati, S, Buonauro, A, Cordeddu, W, Curcio, R, Dalbeni, A, D'Agnano, S, De Feo, M, Donnarumma, E, Fei, M, Gambino, C, Giorgini, P, Lombardi, R, Miceli, G, Naccarato, P, Noviello, S, Olivieri, G, Parente, R, Pignataro, F, Poma, S, Porceddu, E, Pucci, G, Ricchio, M, Sabena, A, Salice, M, Santarossa, C, Savona, A, Savrie, C, Scicali, R, Stabile, M, Talerico, G, Talia, M, Tassone, E, Teatini, T, Tombolini, E, Traversa, M, Vettore, E, Vignal, A, Vilardi, L, Villani, R, Vitale, F, Cicco S., D'Abbondanza M., Proietti M., Zaccone V., Pes C., Caradio F., Mattioli M., Piano S., Marra A. M., Nobili A., Mannucci P. M., Pietrangelo A., Sesti G., Buzzetti E., Salzano A., Cimellaro A., Perticone F., Violi F., Corazza G. R., Corrao S., Marengoni A., Salerno F., Cesari M., Tettamanti M., Pasina L., Franchi C., Novella A., Miglio G., Galbussera A. A., Ardoino I., Prisco D., Silvestri E., Emmi G., Bettiol A., Mattioli I., Biolo G., Zanetti M., Bartelloni G., Zaccari M., Chiuch M., Vanoli M., Grignani G., Pulixi E. A., Pirro M., Lupattelli G., Bianconi V., Alcidi R., Giotta A., Mannarino M. R., Girelli D., Busti F., Marchi G., Barbagallo M., Dominguez L., Beneduce V., Cacioppo F., Natoli G., Mularo S., Raspanti M., Argano C., Cavallaro F., Zoli M., Matacena M. L., Orio G., Magnolfi E., Serafini G., Simili A., Brunori M., Lazzari I., Cappellini M. D., Fabio G., De Amicis M. M., De Luca G., Scaramellini N., Di Stefano V., Leoni S., Seghezzi S., Di Mauro A. D., Maira D., Mancarella M., Lucchi T., Rossi P. D., Clerici M., Bonini G., Conti F., Prolo S., Fabrizi M., Martelengo M., Vigani G., Di Sabatino A., Miceli E., Lenti M. V., Pisati M., Pitotti L., Padula D., Antoci V., Cambie G., Pontremoli R., Beccati V., Nobili G., Leoncini G., Alberto J., Cattaneo F., Anastasio L., Sofia L., Carbone M., Cipollone F., Guagnano M. T., Rossi I., Valeriani E., D'Ardes D., Esposito L., Sestili S., Angelucci E., Mancuso G., Calipari D., Bartone M., Delitala G., Berria M., Delitala A., Muscaritoli M., Molfino A., Petrillo E., Giorgi A., Gracin C., Imbimbo G., Zuccala G., D'Aurizio G., Romanelli G., Volpini A., Lucente D., Manzoni F., Pirozzi A., Zucchelli A., Picardi A., Gentilucci U. V., Gallo P., Dell'Unto C., Bellelli G., Corsi M., Antonucci C., Sidoli C., Principato G., Bonfanti A., Szabo H., Mazzola P., Piazzoli A., Arturi F., Succurro E., Tassone B., Giofre F., Serra M. G., Bleve M. A., Brucato A., De Falco T., Negro E., Brenna M., Trotta L., Squintani G. L., Randi M. L., Fabris F., Bertozzi I., Bogoni G., Rabuini M. V., Prandini T., Ratti F., Zurlo C., Cerruti L., Cosi E., Manfredini R., Fabbian F., Boari B., De Giorgi A., Tiseo R., Paolisso G., Rizzo M. R., Catalano C., Di Meo I., Borghi C., Strocchi E., Ianniello E., Soldati M., Schiavone S., Bragagni A., Leoni F. G., De Sando V., Scarduelli S., Cammarosano M., Pareo I., Sabba C., Vella F. S., Suppressa P., De Vincenzo G. M., Comitangelo A., Amoruso E., Custodero C., Re G., Schilardi A., Loparco F., Fenoglio L., Falcetta A., Giraudo A. V., D'Aniano S., Fracanzani A. L., Tiraboschi S., Cespiati A., Oberti G., Sigon G., Cinque F., Peyvandi F., Rossio R., Colombo G., Agosti P., Pagliaro E., Semproni E., Ciro C., Monzani V., Savojardo V., Ceriani G., Folli C., Pallini G., Montecucco F., Ottonello L., Caserza L., Vischi G., Kassem S., Liberale L., Liberato N. L., Tognin T., Purrello F., Di Pino A., Piro S., Rozzini R., Falanga L., Pisciotta M. S., Bellucci F. B., Buffelli S., Ferrandina C., Mazzeo F., Spazzini E., Cono G., Cesaroni G., Montrucchio G., Peasso P., Favale E., Poletto C., Margaria C., Sanino M., Perri L., Guasti L., Rotunno F., Castiglioni L., Maresca A., Squizzato A., Campiotti L., Grossi A., Diprizio R. D., Dentali F., Bertolotti M., Mussi C., Lancellotti G., Libbra M. V., Galassi M., Grassi Y., Greco A., Bigi E., Pellegrini E., Orlandi L., Dondi G., Carulli L., Sciacqua A., Perticone M., Battaglia R., Maio R., Scozzafava A., Condoleo V., Falbo T., Colangelo L., Filice M., Clausi E., Stanghellini V., Ruggeri E., del Vecchio S., Benzoni I., Salvi A., Leonardi R., Damiani G., Moroncini G., Capeci W., Martino G. P., Biondi L., Pettinari P., Ormas M., Filippini E., Benfaremo D., Romiti R., Ghio R., Col A. D., Minisola S., Cilli M., Labbadia G., Afeltra A., Marigliano B., Pipita M. E., Castellino P., Zanoli L., Gennaro A., Gaudio A., Pignataro S., Mete F., Gino M., Moreo G., Pina G., Ballestrero A., Ferrando F., Gonella R., Cerminara D., Setti P., Traversa C., Scarsi C., Graziella B., Baldassarre S., Fragapani S., Gruden G., Berti F., Famularo G., Tarsitani P., Castello R., Pasino M., Maggio M. G., Ceda G. P., Morganti S., Artoni A., Grossi M., Del Giacco S., Firinu D., Costanzo G., Argiolas G., Paoletti G., Losa F., Montalto G., Licata A., Montalto F. A., Corica F., Basile G., Catalano A., Bellone F., Principato C., Malatino L., Stancanelli B., Terranova V., Di Marca S., Di Quattro R., La Malfa L., Caruso R., Mecocci P., Ruggiero C., Boccardi V., Meschi T., Ticinesi A., Nouvenne A., Minuz P., Fondrieschi L., Imperiale G. N., Morellini S., Pirisi M., Fra G. P., Sola D., Bellan M., Quadri R., Larovere E., Novelli M., Simeone E., Scurti R., Tolloso F., Tarquini R., Valoriani A., Dolenti S., Vannini G., Volpi R., Bocchi P., Vignali A., Harari S., Lonati C., Napoli F., Aiello I., Salvatore T., Monaco L., Ricozzi C., Pilotto A., Indiano I., Gandolfo F., Pasini F. L., Capecchi P. L., Nuti R., Valenti R., Ruvio M., Cappelli S., Palazzuoli A., Bernardi M., Bassi S. L., Santi L., Zaccherini G., Durante V., Tirotta D., Eusebi G., Cattaneo M., Amoruso M. V., Fracasso P., Fasolino C., Tresoldi M., Bozzolo E., Damanti S., Porta M., Armentaro G., Arnone M. I., Barone M., Bertolino L., Bianco S., Binello N., Brancati S., Buonauro A., Cordeddu W., Curcio R., Dalbeni A., D'Agnano S., De Feo M., Donnarumma E., Fei M., Gambino C. G., Giorgini P., Lombardi R., Miceli G., Naccarato P., Noviello S., Olivieri G., Parente R., Pignataro F. S., Poma S., Porceddu E., Pucci G., Ricchio M., Sabena A., Salice M., Santarossa C., Savona A., Savrie C., Scicali R., Stabile M., Talerico G., Talia M., Tassone E. J., Teatini T., Tombolini E., Traversa M., Vettore E., Vignal A., Vilardi L., Villani R., Vitale F., Cicco, S, D'Abbondanza, M, Proietti, M, Zaccone, V, Pes, C, Caradio, F, Mattioli, M, Piano, S, Marra, A, Nobili, A, Mannucci, P, Pietrangelo, A, Sesti, G, Buzzetti, E, Salzano, A, Cimellaro, A, Perticone, F, Violi, F, Corazza, G, Corrao, S, Marengoni, A, Salerno, F, Cesari, M, Tettamanti, M, Pasina, L, Franchi, C, Novella, A, Miglio, G, Galbussera, A, Ardoino, I, Prisco, D, Silvestri, E, Emmi, G, Bettiol, A, Mattioli, I, Biolo, G, Zanetti, M, Bartelloni, G, Zaccari, M, Chiuch, M, Vanoli, M, Grignani, G, Pulixi, E, Pirro, M, Lupattelli, G, Bianconi, V, Alcidi, R, Giotta, A, Mannarino, M, Girelli, D, Busti, F, Marchi, G, Barbagallo, M, Dominguez, L, Beneduce, V, Cacioppo, F, Natoli, G, Mularo, S, Raspanti, M, Argano, C, Cavallaro, F, Zoli, M, Matacena, M, Orio, G, Magnolfi, E, Serafini, G, Simili, A, Brunori, M, Lazzari, I, Cappellini, M, Fabio, G, De Amicis, M, De Luca, G, Scaramellini, N, Di Stefano, V, Leoni, S, Seghezzi, S, Di Mauro, A, Maira, D, Mancarella, M, Lucchi, T, Rossi, P, Clerici, M, Bonini, G, Conti, F, Prolo, S, Fabrizi, M, Martelengo, M, Vigani, G, Di Sabatino, A, Miceli, E, Lenti, M, Pisati, M, Pitotti, L, Padula, D, Antoci, V, Cambie, G, Pontremoli, R, Beccati, V, Nobili, G, Leoncini, G, Alberto, J, Cattaneo, F, Anastasio, L, Sofia, L, Carbone, M, Cipollone, F, Guagnano, M, Rossi, I, Valeriani, E, D'Ardes, D, Esposito, L, Sestili, S, Angelucci, E, Mancuso, G, Calipari, D, Bartone, M, Delitala, G, Berria, M, Delitala, A, Muscaritoli, M, Molfino, A, Petrillo, E, Giorgi, A, Gracin, C, Imbimbo, G, Zuccala, G, D'Aurizio, G, Romanelli, G, Volpini, A, Lucente, D, Manzoni, F, Pirozzi, A, Zucchelli, A, Picardi, A, Gentilucci, U, Gallo, P, Dell'Unto, C, Bellelli, G, Corsi, M, Antonucci, C, Sidoli, C, Principato, G, Bonfanti, A, Szabo, H, Mazzola, P, Piazzoli, A, Arturi, F, Succurro, E, Tassone, B, Giofre, F, Serra, M, Bleve, M, Brucato, A, De Falco, T, Negro, E, Brenna, M, Trotta, L, Squintani, G, Randi, M, Fabris, F, Bertozzi, I, Bogoni, G, Rabuini, M, Prandini, T, Ratti, F, Zurlo, C, Cerruti, L, Cosi, E, Manfredini, R, Fabbian, F, Boari, B, De Giorgi, A, Tiseo, R, Paolisso, G, Rizzo, M, Catalano, C, Di Meo, I, Borghi, C, Strocchi, E, Ianniello, E, Soldati, M, Schiavone, S, Bragagni, A, Leoni, F, De Sando, V, Scarduelli, S, Cammarosano, M, Pareo, I, Sabba, C, Vella, F, Suppressa, P, De Vincenzo, G, Comitangelo, A, Amoruso, E, Custodero, C, Re, G, Schilardi, A, Loparco, F, Fenoglio, L, Falcetta, A, Giraudo, A, D'Aniano, S, Fracanzani, A, Tiraboschi, S, Cespiati, A, Oberti, G, Sigon, G, Cinque, F, Peyvandi, F, Rossio, R, Colombo, G, Agosti, P, Pagliaro, E, Semproni, E, Ciro, C, Monzani, V, Savojardo, V, Ceriani, G, Folli, C, Pallini, G, Montecucco, F, Ottonello, L, Caserza, L, Vischi, G, Kassem, S, Liberale, L, Liberato, N, Tognin, T, Purrello, F, Di Pino, A, Piro, S, Rozzini, R, Falanga, L, Pisciotta, M, Bellucci, F, Buffelli, S, Ferrandina, C, Mazzeo, F, Spazzini, E, Cono, G, Cesaroni, G, Montrucchio, G, Peasso, P, Favale, E, Poletto, C, Margaria, C, Sanino, M, Perri, L, Guasti, L, Rotunno, F, Castiglioni, L, Maresca, A, Squizzato, A, Campiotti, L, Grossi, A, Diprizio, R, Dentali, F, Bertolotti, M, Mussi, C, Lancellotti, G, Libbra, M, Galassi, M, Grassi, Y, Greco, A, Bigi, E, Pellegrini, E, Orlandi, L, Dondi, G, Carulli, L, Sciacqua, A, Perticone, M, Battaglia, R, Maio, R, Scozzafava, A, Condoleo, V, Falbo, T, Colangelo, L, Filice, M, Clausi, E, Stanghellini, V, Ruggeri, E, del Vecchio, S, Benzoni, I, Salvi, A, Leonardi, R, Damiani, G, Moroncini, G, Capeci, W, Martino, G, Biondi, L, Pettinari, P, Ormas, M, Filippini, E, Benfaremo, D, Romiti, R, Ghio, R, Col, A, Minisola, S, Cilli, M, Labbadia, G, Afeltra, A, Marigliano, B, Pipita, M, Castellino, P, Zanoli, L, Gennaro, A, Gaudio, A, Pignataro, S, Mete, F, Gino, M, Moreo, G, Pina, G, Ballestrero, A, Ferrando, F, Gonella, R, Cerminara, D, Setti, P, Traversa, C, Scarsi, C, Graziella, B, Baldassarre, S, Fragapani, S, Gruden, G, Berti, F, Famularo, G, Tarsitani, P, Castello, R, Pasino, M, Maggio, M, Ceda, G, Morganti, S, Artoni, A, Grossi, M, Del Giacco, S, Firinu, D, Costanzo, G, Argiolas, G, Paoletti, G, Losa, F, Montalto, G, Licata, A, Montalto, F, Corica, F, Basile, G, Catalano, A, Bellone, F, Principato, C, Malatino, L, Stancanelli, B, Terranova, V, Di Marca, S, Di Quattro, R, La Malfa, L, Caruso, R, Mecocci, P, Ruggiero, C, Boccardi, V, Meschi, T, Ticinesi, A, Nouvenne, A, Minuz, P, Fondrieschi, L, Imperiale, G, Morellini, S, Pirisi, M, Fra, G, Sola, D, Bellan, M, Quadri, R, Larovere, E, Novelli, M, Simeone, E, Scurti, R, Tolloso, F, Tarquini, R, Valoriani, A, Dolenti, S, Vannini, G, Volpi, R, Bocchi, P, Vignali, A, Harari, S, Lonati, C, Napoli, F, Aiello, I, Salvatore, T, Monaco, L, Ricozzi, C, Pilotto, A, Indiano, I, Gandolfo, F, Pasini, F, Capecchi, P, Nuti, R, Valenti, R, Ruvio, M, Cappelli, S, Palazzuoli, A, Bernardi, M, Bassi, S, 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M., Nobili A., Mannucci P. M., Pietrangelo A., Sesti G., Buzzetti E., Salzano A., Cimellaro A., Perticone F., Violi F., Corazza G. R., Corrao S., Marengoni A., Salerno F., Cesari M., Tettamanti M., Pasina L., Franchi C., Novella A., Miglio G., Galbussera A. A., Ardoino I., Prisco D., Silvestri E., Emmi G., Bettiol A., Mattioli I., Biolo G., Zanetti M., Bartelloni G., Zaccari M., Chiuch M., Vanoli M., Grignani G., Pulixi E. A., Pirro M., Lupattelli G., Bianconi V., Alcidi R., Giotta A., Mannarino M. R., Girelli D., Busti F., Marchi G., Barbagallo M., Dominguez L., Beneduce V., Cacioppo F., Natoli G., Mularo S., Raspanti M., Argano C., Cavallaro F., Zoli M., Matacena M. L., Orio G., Magnolfi E., Serafini G., Simili A., Brunori M., Lazzari I., Cappellini M. D., Fabio G., De Amicis M. M., De Luca G., Scaramellini N., Di Stefano V., Leoni S., Seghezzi S., Di Mauro A. D., Maira D., Mancarella M., Lucchi T., Rossi P. D., Clerici M., Bonini G., Conti F., Prolo S., Fabrizi M., Martelengo M., Vigani G., Di Sabatino A., Miceli E., Lenti M. V., Pisati M., Pitotti L., Padula D., Antoci V., Cambie G., Pontremoli R., Beccati V., Nobili G., Leoncini G., Alberto J., Cattaneo F., Anastasio L., Sofia L., Carbone M., Cipollone F., Guagnano M. T., Rossi I., Valeriani E., D'Ardes D., Esposito L., Sestili S., Angelucci E., Mancuso G., Calipari D., Bartone M., Delitala G., Berria M., Delitala A., Muscaritoli M., Molfino A., Petrillo E., Giorgi A., Gracin C., Imbimbo G., Zuccala G., D'Aurizio G., Romanelli G., Volpini A., Lucente D., Manzoni F., Pirozzi A., Zucchelli A., Picardi A., Gentilucci U. V., Gallo P., Dell'Unto C., Bellelli G., Corsi M., Antonucci C., Sidoli C., Principato G., Bonfanti A., Szabo H., Mazzola P., Piazzoli A., Arturi F., Succurro E., Tassone B., Giofre F., Serra M. G., Bleve M. A., Brucato A., De Falco T., Negro E., Brenna M., Trotta L., Squintani G. L., Randi M. L., Fabris F., Bertozzi I., Bogoni G., Rabuini M. V., Prandini T., Ratti F., Zurlo C., Cerruti L., Cosi E., Manfredini R., Fabbian F., Boari B., De Giorgi A., Tiseo R., Paolisso G., Rizzo M. R., Catalano C., Di Meo I., Borghi C., Strocchi E., Ianniello E., Soldati M., Schiavone S., Bragagni A., Leoni F. G., De Sando V., Scarduelli S., Cammarosano M., Pareo I., Sabba C., Vella F. S., Suppressa P., De Vincenzo G. M., Comitangelo A., Amoruso E., Custodero C., Re G., Schilardi A., Loparco F., Fenoglio L., Falcetta A., Giraudo A. V., D'Aniano S., Fracanzani A. L., Tiraboschi S., Cespiati A., Oberti G., Sigon G., Cinque F., Peyvandi F., Rossio R., Colombo G., Agosti P., Pagliaro E., Semproni E., Ciro C., Monzani V., Savojardo V., Ceriani G., Folli C., Pallini G., Montecucco F., Ottonello L., Caserza L., Vischi G., Kassem S., Liberale L., Liberato N. L., Tognin T., Purrello F., Di Pino A., Piro S., Rozzini R., Falanga L., Pisciotta M. S., Bellucci F. B., Buffelli S., Ferrandina C., Mazzeo F., Spazzini E., Cono G., Cesaroni G., Montrucchio G., Peasso P., Favale E., Poletto C., Margaria C., Sanino M., Perri L., Guasti L., Rotunno F., Castiglioni L., Maresca A., Squizzato A., Campiotti L., Grossi A., Diprizio R. D., Dentali F., Bertolotti M., Mussi C., Lancellotti G., Libbra M. V., Galassi M., Grassi Y., Greco A., Bigi E., Pellegrini E., Orlandi L., Dondi G., Carulli L., Sciacqua A., Perticone M., Battaglia R., Maio R., Scozzafava A., Condoleo V., Falbo T., Colangelo L., Filice M., Clausi E., Stanghellini V., Ruggeri E., del Vecchio S., Benzoni I., Salvi A., Leonardi R., Damiani G., Moroncini G., Capeci W., Martino G. P., Biondi L., Pettinari P., Ormas M., Filippini E., Benfaremo D., Romiti R., Ghio R., Col A. D., Minisola S., Cilli M., Labbadia G., Afeltra A., Marigliano B., Pipita M. 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S., Poma S., Porceddu E., Pucci G., Ricchio M., Sabena A., Salice M., Santarossa C., Savona A., Savrie C., Scicali R., Stabile M., Talerico G., Talia M., Tassone E. J., Teatini T., Tombolini E., Traversa M., Vettore E., Vignal A., Vilardi L., Villani R., and Vitale F.

Abstract

Background: Hypertension management in older patients represents a challenge, particularly when hospitalized. Objective: The objective of this study is to investigate the determinants and related outcomes of antihypertensive drug prescription in a cohort of older hospitalized patients. Methods: A total of 5671 patients from REPOSI (a prospective multicentre observational register of older Italian in-patients from internal medicine or geriatric wards) were considered; 4377 (77.2%) were hypertensive. Minimum treatment (MT) for hypertension was defined according to the 2018 ESC guidelines [an angiotensin-converting-enzyme-inhibitor (ACE-I) or an angiotensin-receptor-blocker (ARB) with a calcium-channel-blocker (CCB) and/or a thiazide diuretic; if >80 years old, an ACE-I or ARB or CCB or thiazide diuretic]. Determinants of MT discontinuation at discharge were assessed. Study outcomes were any cause rehospitalization/all cause death, all-cause death, cardiovascular (CV) hospitalization/death, CV death, non-CV death, evaluated according to the presence of MT at discharge. Results: Hypertensive patients were older than normotensives, with a more impaired functional status, higher burden of comorbidity and polypharmacy. A total of 2233 patients were on MT at admission, 1766 were on MT at discharge. Discontinuation of MT was associated with the presence of comorbidities (lower odds for diabetes, higher odds for chronic kidney disease and dementia). An adjusted multivariable logistic regression analysis showed that MT for hypertension at discharge was associated with lower risk of all-cause death, all-cause death/hospitalization, CV death, CV death/hospitalization and non-CV death. Conclusions: Guidelines-suggested MT for hypertension at discharge is associated with a lower risk of adverse clinical outcomes. Nevertheless, changes in antihypertensive treatment still occur in a significant proportion of older hospitalized patients.

Published
2023

37. Clinical features and outcomes of elderly hospitalised patients with chronic obstructive pulmonary disease, heart failure or both

Author

Crisafulli, E, Sartori, G, Vianello, A, Busti, F, Nobili, A, Mannucci, P, Girelli, D, Sesti, G, Pietrangelo, A, Perticone, F, Violi, F, Corrao, S, Marengoni, A, Tettamanti, M, Pasina, L, Franchi, C, Novella, A, Miglio, G, Galbussera, A, Ardoino, I, Prisco, D, Silvestri, E, Emmi, G, Bettiol, A, Mattioli, I, Biolo, G, Zanetti, M, Bartelloni, G, Zaccari, M, Chiuch, M, Vanoli, M, Grignani, G, Pulixi, E, Pirro, M, Lupattelli, G, Bianconi, V, Alcidi, R, Giotta, A, Mannarino, M, Marchi, G, Barbagallo, M, Dominguez, L, Beneduce, V, Cacioppo, F, Natoli, G, Mularo, S, Raspanti, M, Argano, C, Cavallaro, F, Zoli, M, Matacena, M, Orio, G, Magnolfi, E, Serafini, G, Simili, A, Brunori, M, Lazzari, I, Cappellini, M, Fabio, G, De Amicis, M, De Luca, G, Scaramellini, N, Di Stefano, V, Leoni, S, Seghezzi, S, Di Mauro, A, Maira, D, Mancarella, M, Lucchi, T, Rossi, P, Clerici, M, Bonini, G, Conti, F, Prolo, S, Fabrizi, M, Martelengo, M, Vigani, G, Nicolini, P, Di Sabatino, A, Miceli, E, Lenti, M, Pisati, M, Pitotti, L, Padula, D, Antoci, V, Cambie, G, Pontremoli, R, Beccati, V, Nobili, G, Leoncini, G, Alberto, J, Cattaneo, F, Anastasio, L, Sofia, L, Carbone, M, Cipollone, F, Guagnano, M, Rossi, I, Valeriani, E, D'Ardes, D, Esposito, L, Sestili, S, Angelucci, E, Mancuso, G, Calipari, D, Bartone, M, Delitala, G, Berria, M, Delitala, A, Muscaritoli, M, Molfino, A, Petrillo, E, Giorgi, A, Gracin, C, Imbimbo, G, Zuccala, G, D'Aurizio, G, Romanelli, G, Volpini, A, Lucente, D, Manzoni, F, Pirozzi, A, Zucchelli, A, Picardi, A, Gentilucci, U, Gallo, P, Dell'Unto, C, Bellelli, G, Corsi, M, Antonucci, C, Sidoli, C, Principato, G, Bonfanti, A, Szabo, H, Mazzola, P, Piazzoli, A, Arturi, F, Succurro, E, Tassone, B, Giofre, F, Serra, M, Bleve, M, Brucato, A, De Falco, T, Negro, E, Brenna, M, Trotta, L, Squintani, G, Randi, M, Fabris, F, Bertozzi, I, Bogoni, G, Rabuini, M, Prandini, T, Ratti, F, Zurlo, C, Cerruti, L, Cosi, E, Manfredini, R, Boari, B, De Giorgi, A, Tiseo, R, Viglione, G, Savrie, C, Paolisso, G, Rizzo, M, Catalano, C, Di Meo, I, Borghi, C, Strocchi, E, Ianniello, E, Soldati, M, Schiavone, S, Bragagni, A, Leoni, F, De Sando, V, Scarduelli, S, Cammarosano, M, Pareo, I, Sabba, C, Vella, F, Suppressa, P, De Vincenzo, G, Comitangelo, A, Amoruso, E, Custodero, C, Re, G, Schilardi, A, Loparco, F, Fenoglio, L, Falcetta, A, Giraudo, A, D'Aniano, S, Fracanzani, A, Tiraboschi, S, Cespiati, A, Oberti, G, Sigon, G, Cinque, F, Peyvandi, F, Rossio, R, Colombo, G, Agosti, P, Pagliaro, E, Semproni, E, Ciro, C, Monzani, V, Savojardo, V, Ceriani, G, Folli, C, Salerno, F, Pallini, G, Montecucco, F, Ottonello, L, Caserza, L, Vischi, G, Kassem, S, Liberale, L, Liberato, N, Tognin, T, Purrello, F, Di Pino, A, Piro, S, Rozzini, R, Falanga, L, Pisciotta, M, Bellucci, F, Buffelli, S, Ferrandina, C, Mazzeo, F, Spazzini, E, Cono, G, Cesaroni, G, Montrucchio, G, Peasso, P, Favale, E, Poletto, C, Margaria, C, Sanino, M, Perri, L, Guasti, L, Rotunno, F, Castiglioni, L, Maresca, A, Squizzato, A, Campiotti, L, Grossi, A, Diprizio, R, Dentali, F, Bertolotti, M, Mussi, C, Lancellotti, G, Libbra, M, Galassi, M, Grassi, Y, Greco, A, Bigi, E, Pellegrini, E, Orlandi, L, Dondi, G, Carulli, L, Sciacqua, A, Perticone, M, Battaglia, R, Maio, R, Scozzafava, A, Condoleo, V, Falbo, T, Colangelo, L, Filice, M, Clausi, E, Stanghellini, V, Ruggeri, E, Del Vecchio, S, Benzoni, I, Salvi, A, Leonardi, R, Damiani, G, Moroncini, G, Capeci, W, Mattioli, M, Martino, G, Biondi, L, Pettinari, P, Ormas, M, Filippini, E, Benfaremo, D, Romiti, R, Ghio, R, Dal Col, A, Minisola, S, Cilli, M, Labbadia, G, Afeltra, A, Marigliano, B, Pipita, M, Castellino, P, Zanoli, L, Gennaro, A, Gaudio, A, Pignataro, S, Mete, F, Gino, M, Moreo, G, Pina, G, Ballestrero, A, Ferrando, F, Gonella, R, Cerminara, D, Setti, P, Traversa, C, Scarsi, C, Graziella, B, Baldassarre, S, Fragapani, S, Gruden, G, Berti, F, Famularo, G, Tarsitani, P, Castello, R, Pasino, M, Gian Paolo Ceda, M, Morganti, S, Artoni, A, Grossi, M, Del Giacco, S, Firinu, D, Costanzo, G, Argiolas, G, Paoletti, G, Losa, F, Montalto, G, Licata, A, Montalto, F, Rizzo, A, Corica, F, Basile, G, Catalano, A, Bellone, F, Principato, C, Malatino, L, Stancanelli, B, Terranova, V, Di Marca, S, Di Quattro, R, La Malfa, L, Caruso, R, Mecocci, P, Ruggiero, C, Boccardi, V, Meschi, T, Ticinesi, A, Nouvenne, A, Minuz, P, Fondrieschi, L, Imperiale, G, Morellini, S, Pirisi, M, Fra, G, Sola, D, Bellan, M, Quadri, R, Larovere, E, Novelli, M, Simeone, E, Scurti, R, Tolloso, F, Tarquini, R, Valoriani, A, Dolenti, S, Vannini, G, Volpi, R, Bocchi, P, Vignali, A, Harari, S, Lonati, C, Napoli, F, Aiello, I, Salvatore, T, Monaco, L, Ricozzi, C, Pilotto, A, Indiano, I, Gandolfo, F, Pasini, F, Capecchi, P, Nuti, R, Valenti, R, Ruvio, M, Cappelli, S, Palazzuoli, A, Bernardi, M, Li Bassi, S, Santi, L, Zaccherini, G, Durante, V, Tirotta, D, Eusebi, G, Cattaneo, M, Amoruso, M, Fracasso, P, Fasolino, C, Tresoldi, M, Bozzolo, E, Damanti, S, Porta, M, Crisafulli E., Sartori G., Vianello A., Busti F., Nobili A., Mannucci P. M., Girelli D., Sesti G., Pietrangelo A., Perticone F., Violi F., Corrao S., Marengoni A., Tettamanti M., Pasina L., Franchi C., Novella A., Miglio G., Galbussera A. A., Ardoino I., Prisco D., Silvestri E., Emmi G., Bettiol A., Mattioli I., Biolo G., Zanetti M., Bartelloni G., Zaccari M., Chiuch M., Vanoli M., Grignani G., Pulixi E. A., Pirro M., Lupattelli G., Bianconi V., Alcidi R., Giotta A., Mannarino M. R., Marchi G., Barbagallo M., Dominguez L., Beneduce V., Cacioppo F., Natoli G., Mularo S., Raspanti M., Argano C., Cavallaro F., Zoli M., Matacena M. L., Orio G., Magnolfi E., Serafini G., Simili A., Brunori M., Lazzari I., Cappellini M. D., Fabio G., De Amicis M. M., De Luca G., Scaramellini N., Di Stefano V., Leoni S., Seghezzi S., Di Mauro A. D., Maira D., Mancarella M., Lucchi T., Rossi P. D., Clerici M., Bonini G., Conti F., Prolo S., Fabrizi M., Martelengo M., Vigani G., Nicolini P., Di Sabatino A., Miceli E., Lenti M. V., Pisati M., Pitotti L., Padula D., Antoci V., Cambie G., Pontremoli R., Beccati V., Nobili G., Leoncini G., Alberto J., Cattaneo F., Anastasio L., Sofia L., Carbone M., Cipollone F., Guagnano M. T., Rossi I., Valeriani E., D'Ardes D., Esposito L., Sestili S., Angelucci E., Mancuso G., Calipari D., Bartone M., Delitala G., Berria M., Delitala A., Muscaritoli M., Molfino A., Petrillo E., Giorgi A., Gracin C., Imbimbo G., Zuccala G., D'Aurizio G., Romanelli G., Volpini A., Lucente D., Manzoni F., Pirozzi A., Zucchelli A., Picardi A., Gentilucci U. V., Gallo P., Dell'Unto C., Bellelli G., Corsi M., Antonucci C., Sidoli C., Principato G., Bonfanti A., Szabo H., Mazzola P., Piazzoli A., Arturi F., Succurro E., Tassone B., Giofre F., Serra M. G., Bleve M. A., Brucato A., De Falco T., Negro E., Brenna M., Trotta L., Squintani G. L., Randi M. L., Fabris F., Bertozzi I., Bogoni G., Rabuini M. V., Prandini T., Ratti F., Zurlo C., Cerruti L., Cosi E., Manfredini R., Boari B., De Giorgi A., Tiseo R., Viglione G. M., Savrie C., Paolisso G., Rizzo M. R., Catalano C., Di Meo I., Borghi C., Strocchi E., Ianniello E., Soldati M., Schiavone S., Bragagni A., Leoni F. G., De Sando V., Scarduelli S., Cammarosano M., Pareo I., Sabba C., Vella F. S., Suppressa P., De Vincenzo G. M., Comitangelo A., Amoruso E., Custodero C., Re G., Schilardi A., Loparco F., Fenoglio L., Falcetta A., Giraudo A. V., D'Aniano S., Fracanzani A. L., Tiraboschi S., Cespiati A., Oberti G., Sigon G., Cinque F., Peyvandi F., Rossio R., Colombo G., Agosti P., Pagliaro E., Semproni E., Ciro C., Monzani V., Savojardo V., Ceriani G., Folli C., Salerno F., Pallini G., Montecucco F., Ottonello L., Caserza L., Vischi G., Kassem S., Liberale L., Liberato N. L., Tognin T., Purrello F., Di Pino A., Piro S., Rozzini R., Falanga L., Pisciotta M. S., Bellucci F. B., Buffelli S., Ferrandina C., Mazzeo F., Spazzini E., Cono G., Cesaroni G., Montrucchio G., Peasso P., Favale E., Poletto C., Margaria C., Sanino M., Perri L., Guasti L., Rotunno F., Castiglioni L., Maresca A., Squizzato A., Campiotti L., Grossi A., Diprizio R. D., Dentali F., Bertolotti M., Mussi C., Lancellotti G., Libbra M. V., Galassi M., Grassi Y., Greco A., Bigi E., Pellegrini E., Orlandi L., Dondi G., Carulli L., Sciacqua A., Perticone M., Battaglia R., Maio R., Scozzafava A., Condoleo V., Falbo T., Colangelo L., Filice M., Clausi E., Stanghellini V., Ruggeri E., Del Vecchio S., Benzoni I., Salvi A., Leonardi R., Damiani G., Moroncini G., Capeci W., Mattioli M., Martino G. P., Biondi L., Pettinari P., Ormas M., Filippini E., Benfaremo D., Romiti R., Ghio R., Dal Col A., Minisola S., Cilli M., Labbadia G., Afeltra A., Marigliano B., Pipita M. E., Castellino P., Zanoli L., Gennaro A., Gaudio A., Pignataro S., Mete F., Gino M., Moreo G., Pina G., Ballestrero A., Ferrando F., Gonella R., Cerminara D., Setti P., Traversa C., Scarsi C., Graziella B., Baldassarre S., Fragapani S., Gruden G., Berti F., Famularo G., Tarsitani P., Castello R., Pasino M., Gian Paolo Ceda M. G. M., Morganti S., Artoni A., Grossi M., Del Giacco S., Firinu D., Costanzo G., Argiolas G., Paoletti G., Losa F., Montalto G., Licata A., Montalto F. A., Rizzo A., Corica F., Basile G., Catalano A., Bellone F., Principato C., Malatino L., Stancanelli B., Terranova V., Di Marca S., Di Quattro R., La Malfa L., Caruso R., Mecocci P., Ruggiero C., Boccardi V., Meschi T., Ticinesi A., Nouvenne A., Minuz P., Fondrieschi L., Imperiale G. N., Morellini S., Pirisi M., Fra G. P., Sola D., Bellan M., Quadri R., Larovere E., Novelli M., Simeone E., Scurti R., Tolloso F., Tarquini R., Valoriani A., Dolenti S., Vannini G., Volpi R., Bocchi P., Vignali A., Harari S., Lonati C., Napoli F., Aiello I., Salvatore T., Monaco L., Ricozzi C., Pilotto A., Indiano I., Gandolfo F., Pasini F. L., Capecchi P. L., Nuti R., Valenti R., Ruvio M., Cappelli S., Palazzuoli A., Bernardi M., Li Bassi S., Santi L., Zaccherini G., Durante V., Tirotta D., Eusebi G., Cattaneo M., Amoruso M. V., Fracasso P., Fasolino C., Tresoldi M., Bozzolo E., Damanti S., Porta M., Crisafulli, E, Sartori, G, Vianello, A, Busti, F, Nobili, A, Mannucci, P, Girelli, D, Sesti, G, Pietrangelo, A, Perticone, F, Violi, F, Corrao, S, Marengoni, A, Tettamanti, M, Pasina, L, Franchi, C, Novella, A, Miglio, G, Galbussera, A, Ardoino, I, Prisco, D, Silvestri, E, Emmi, G, Bettiol, A, Mattioli, I, Biolo, G, Zanetti, M, Bartelloni, G, Zaccari, M, Chiuch, M, Vanoli, M, Grignani, G, Pulixi, E, Pirro, M, Lupattelli, G, Bianconi, V, Alcidi, R, Giotta, A, Mannarino, M, Marchi, G, Barbagallo, M, Dominguez, L, Beneduce, V, Cacioppo, F, Natoli, G, Mularo, S, Raspanti, M, Argano, C, Cavallaro, F, Zoli, M, Matacena, M, Orio, G, Magnolfi, E, Serafini, G, Simili, A, Brunori, M, Lazzari, I, Cappellini, M, Fabio, G, De Amicis, M, De Luca, G, Scaramellini, N, Di Stefano, V, Leoni, S, Seghezzi, S, Di Mauro, A, Maira, D, Mancarella, M, Lucchi, T, Rossi, P, Clerici, M, Bonini, G, Conti, F, Prolo, S, Fabrizi, M, 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Fracasso, P, Fasolino, C, Tresoldi, M, Bozzolo, E, Damanti, S, Porta, M, Crisafulli E., Sartori G., Vianello A., Busti F., Nobili A., Mannucci P. M., Girelli D., Sesti G., Pietrangelo A., Perticone F., Violi F., Corrao S., Marengoni A., Tettamanti M., Pasina L., Franchi C., Novella A., Miglio G., Galbussera A. A., Ardoino I., Prisco D., Silvestri E., Emmi G., Bettiol A., Mattioli I., Biolo G., Zanetti M., Bartelloni G., Zaccari M., Chiuch M., Vanoli M., Grignani G., Pulixi E. A., Pirro M., Lupattelli G., Bianconi V., Alcidi R., Giotta A., Mannarino M. R., Marchi G., Barbagallo M., Dominguez L., Beneduce V., Cacioppo F., Natoli G., Mularo S., Raspanti M., Argano C., Cavallaro F., Zoli M., Matacena M. L., Orio G., Magnolfi E., Serafini G., Simili A., Brunori M., Lazzari I., Cappellini M. D., Fabio G., De Amicis M. M., De Luca G., Scaramellini N., Di Stefano V., Leoni S., Seghezzi S., Di Mauro A. D., Maira D., Mancarella M., Lucchi T., Rossi P. D., Clerici M., Bonini G., Conti F., Prolo S., Fabrizi M., Martelengo M., Vigani G., Nicolini P., Di Sabatino A., Miceli E., Lenti M. V., Pisati M., Pitotti L., Padula D., Antoci V., Cambie G., Pontremoli R., Beccati V., Nobili G., Leoncini G., Alberto J., Cattaneo F., Anastasio L., Sofia L., Carbone M., Cipollone F., Guagnano M. T., Rossi I., Valeriani E., D'Ardes D., Esposito L., Sestili S., Angelucci E., Mancuso G., Calipari D., Bartone M., Delitala G., Berria M., Delitala A., Muscaritoli M., Molfino A., Petrillo E., Giorgi A., Gracin C., Imbimbo G., Zuccala G., D'Aurizio G., Romanelli G., Volpini A., Lucente D., Manzoni F., Pirozzi A., Zucchelli A., Picardi A., Gentilucci U. V., Gallo P., Dell'Unto C., Bellelli G., Corsi M., Antonucci C., Sidoli C., Principato G., Bonfanti A., Szabo H., Mazzola P., Piazzoli A., Arturi F., Succurro E., Tassone B., Giofre F., Serra M. G., Bleve M. A., Brucato A., De Falco T., Negro E., Brenna M., Trotta L., Squintani G. L., Randi M. L., Fabris F., Bertozzi I., Bogoni G., Rabuini M. V., Prandini T., Ratti F., Zurlo C., Cerruti L., Cosi E., Manfredini R., Boari B., De Giorgi A., Tiseo R., Viglione G. M., Savrie C., Paolisso G., Rizzo M. R., Catalano C., Di Meo I., Borghi C., Strocchi E., Ianniello E., Soldati M., Schiavone S., Bragagni A., Leoni F. G., De Sando V., Scarduelli S., Cammarosano M., Pareo I., Sabba C., Vella F. S., Suppressa P., De Vincenzo G. M., Comitangelo A., Amoruso E., Custodero C., Re G., Schilardi A., Loparco F., Fenoglio L., Falcetta A., Giraudo A. V., D'Aniano S., Fracanzani A. L., Tiraboschi S., Cespiati A., Oberti G., Sigon G., Cinque F., Peyvandi F., Rossio R., Colombo G., Agosti P., Pagliaro E., Semproni E., Ciro C., Monzani V., Savojardo V., Ceriani G., Folli C., Salerno F., Pallini G., Montecucco F., Ottonello L., Caserza L., Vischi G., Kassem S., Liberale L., Liberato N. L., Tognin T., Purrello F., Di Pino A., Piro S., Rozzini R., Falanga L., Pisciotta M. S., Bellucci F. B., Buffelli S., Ferrandina C., Mazzeo F., Spazzini E., Cono G., Cesaroni G., Montrucchio G., Peasso P., Favale E., Poletto C., Margaria C., Sanino M., Perri L., Guasti L., Rotunno F., Castiglioni L., Maresca A., Squizzato A., Campiotti L., Grossi A., Diprizio R. D., Dentali F., Bertolotti M., Mussi C., Lancellotti G., Libbra M. V., Galassi M., Grassi Y., Greco A., Bigi E., Pellegrini E., Orlandi L., Dondi G., Carulli L., Sciacqua A., Perticone M., Battaglia R., Maio R., Scozzafava A., Condoleo V., Falbo T., Colangelo L., Filice M., Clausi E., Stanghellini V., Ruggeri E., Del Vecchio S., Benzoni I., Salvi A., Leonardi R., Damiani G., Moroncini G., Capeci W., Mattioli M., Martino G. P., Biondi L., Pettinari P., Ormas M., Filippini E., Benfaremo D., Romiti R., Ghio R., Dal Col A., Minisola S., Cilli M., Labbadia G., Afeltra A., Marigliano B., Pipita M. E., Castellino P., Zanoli L., Gennaro A., Gaudio A., Pignataro S., Mete F., Gino M., Moreo G., Pina G., Ballestrero A., Ferrando F., Gonella R., Cerminara D., Setti P., Traversa C., Scarsi C., Graziella B., Baldassarre S., Fragapani S., Gruden G., Berti F., Famularo G., Tarsitani P., Castello R., Pasino M., Gian Paolo Ceda M. G. M., Morganti S., Artoni A., Grossi M., Del Giacco S., Firinu D., Costanzo G., Argiolas G., Paoletti G., Losa F., Montalto G., Licata A., Montalto F. A., Rizzo A., Corica F., Basile G., Catalano A., Bellone F., Principato C., Malatino L., Stancanelli B., Terranova V., Di Marca S., Di Quattro R., La Malfa L., Caruso R., Mecocci P., Ruggiero C., Boccardi V., Meschi T., Ticinesi A., Nouvenne A., Minuz P., Fondrieschi L., Imperiale G. N., Morellini S., Pirisi M., Fra G. P., Sola D., Bellan M., Quadri R., Larovere E., Novelli M., Simeone E., Scurti R., Tolloso F., Tarquini R., Valoriani A., Dolenti S., Vannini G., Volpi R., Bocchi P., Vignali A., Harari S., Lonati C., Napoli F., Aiello I., Salvatore T., Monaco L., Ricozzi C., Pilotto A., Indiano I., Gandolfo F., Pasini F. L., Capecchi P. L., Nuti R., Valenti R., Ruvio M., Cappelli S., Palazzuoli A., Bernardi M., Li Bassi S., Santi L., Zaccherini G., Durante V., Tirotta D., Eusebi G., Cattaneo M., Amoruso M. V., Fracasso P., Fasolino C., Tresoldi M., Bozzolo E., Damanti S., and Porta M.

Abstract

Background and objective: Chronic obstructive pulmonary disease (COPD) and heart failure (HF) mutually increase the risk of being present in the same patient, especially if older. Whether or not this coexistence may be associated with a worse prognosis is debated. Therefore, employing data derived from the REPOSI register, we evaluated the clinical features and outcomes in a population of elderly patients admitted to internal medicine wards and having COPD, HF or COPD + HF. Methods: We measured socio-demographic and anthropometric characteristics, severity and prevalence of comorbidities, clinical and laboratory features during hospitalization, mood disorders, functional independence, drug prescriptions and discharge destination. The primary study outcome was the risk of death. Results: We considered 2,343 elderly hospitalized patients (median age 81 years), of whom 1,154 (49%) had COPD, 813 (35%) HF, and 376 (16%) COPD + HF. Patients with COPD + HF had different characteristics than those with COPD or HF, such as a higher prevalence of previous hospitalizations, comorbidities (especially chronic kidney disease), higher respiratory rate at admission and number of prescribed drugs. Patients with COPD + HF (hazard ratio HR 1.74, 95% confidence intervals CI 1.16–2.61) and patients with dementia (HR 1.75, 95% CI 1.06–2.90) had a higher risk of death at one year. The Kaplan–Meier curves showed a higher mortality risk in the group of patients with COPD + HF for all causes (p = 0.010), respiratory causes (p = 0.006), cardiovascular causes (p = 0.046) and respiratory plus cardiovascular causes (p = 0.009). Conclusion: In this real-life cohort of hospitalized elderly patients, the coexistence of COPD and HF significantly worsened prognosis at one year. This finding may help to better define the care needs of this population.

Published
2023

38. Correction to: Prescription appropriateness of anti-diabetes drugs in elderly patients hospitalized in a clinical setting: evidence from the REPOSI Register (Internal and Emergency Medicine, (2023), 18, 4, (1049-1063), 10.1007/s11739-023-03254-3)

Author

Succurro E., Succurro, E, Novella, A, Nobili, A, Giofre, F, Arturi, F, Sciacqua, A, Andreozzi, F, Pietrangelo, A, Sesti, G, Perticone, F, Violi, F, Corrao, S, Marengoni, A, Tettamanti, M, Pasina, L, Franchi, C, Miglio, G, Ardoino, I, Cantiero, S, Prisco, D, Silvestri, E, Emmi, G, Bettiol, A, Mattioli, I, Mazzetti, M, Biolo, G, Zanetti, M, Bartelloni, G, Zaccari, M, Chiuch, M, Martini, I, Pirro, M, Lupattelli, G, Bianconi, V, Alcidi, R, Giotta, A, Mannarino, M, Girelli, D, Busti, F, Marchi, G, Barbagallo, M, Dominguez, L, Beneduce, V, Cacioppo, F, Natoli, G, Mularo, S, Raspanti, M, Argano, C, Cavallaro, F, Zoli, M, Orio, G, Magnolfi, E, Serafini, G, Brunori, M, Lazzari, I, Simili, A, Fabio, G, De Amicis, M, Luca, G, Scaramellini, N, Stefano, V, Leoni, S, Seghezzi, S, Di Mauro, A, Maira, D, Mancarella, M, Lucchi, T, Clerici, M, Bonini, G, Conti, F, Prolo, S, Fabrizi, M, Martelengo, M, Vigani, G, Nicolini, P, Sabatino, A, Miceli, E, Pisati, M, Pitotti, L, Antoci, V, Cambie, G, Pontremoli, R, Beccati, V, Nobili, G, Leoncini, G, Alberto, J, Cattaneo, F, Anastasio, L, Sofia, L, Carbone, M, Cipollone, F, Rossi, I, Valeriani, E, D'Ardes, D, Cipollone, A, Esposito, L, Sestili, S, Angelucci, E, Mancuso, G, Calipari, D, Bartone, M, Manetti, R, Sircana, M, Berria, M, Delitala, A, Muscaritoli, M, Molfino, A, Petrillo, E, Giorgi, A, Gracin, C, Imbimbo, G, Romanelli, G, Volpini, A, Lucente, D, Manzoni, F, Pirozzi, A, Zucchelli, A, Geneletti, T, Picardi, A, Bellelli, G, Corsi, M, Antonucci, C, Sidoli, C, Principato, G, Bonfanti, A, Szabo, H, Mazzola, P, Piazzoli, A, Tassone, B, De Falco, A, Negro, E, Brenna, M, Trotta, L, Fabris, F, Bertozzi, I, Bogoni, G, Prandini, T, Ratti, F, Zurlo, C, Cerruti, L, Cosi, E, Reni, E, Manfredini, R, Boari, B, Tiseo, R, Savrie, C, Fabbian, F, Paolisso, G, Catalano, C, Meo, I, Sabba, C, Suppressa, P, De Vincenzo, G, Comitangelo, A, Amoruso, E, Custodero, C, Re, G, Barnaba, I, Schilardi, A, Fenoglio, L, Falcetta, A, D'Aniano, S, Tiraboschi, S, Cespiati, A, Oberti, G, Sigon, G, Cinque, F, Colavolpe, L, Curra, J, Alletto, F, Benzoni, G, Peyvandi, F, Rossio, R, Colombo, G, Agosti, P, Pagliaro, E, Semproni, E, Canetta, C, Monzani, V, Savojardo, V, Ceriani, G, Folli, C, Tognin, T, Purrello, F, Pino, A, Piro, S, Rozzini, R, Falanga, L, Boffelli, S, Ferrandina, C, Mazzeo, F, Spazzini, E, Cono, G, Cesaroni, G, Perri, L, Guasti, L, Rotunno, F, Castiglioni, L, Maresca, A, Squizzato, A, Campiotti, L, Grossi, A, Dentali, F, Behnke, V, Perticone, M, Maio, R, Scozzafava, A, Condoleo, V, Clausi, E, Armentaro, G, Panza, A, Stanghellini, V, Ruggeri, E, Vecchio, S, Benzoni, I, Minisola, S, Colangelo, L, Cilli, M, Labbadia, G, Pepe, J, Castellino, P, Zanoli, L, Gaudio, A, Xourafa, A, Spichetti, C, Torre, S, Gennaro, A, Ballestrero, A, Ferrando, F, Gonella, R, Cerminara, D, Setti, P, Traversa, C, Scarsi, C, Famularo, G, Tarsitani, P, Morretti, T, Aglitti, A, Giacco, S, Firinu, D, Costanzo, G, Chessa, S, Montalto, G, Licata, A, Rizzo, A, Corica, F, Basile, G, Catalano, A, Bellone, F, Principato, C, Cocuzza, A, Mecocci, P, Ruggiero, C, Boccardi, V, Meschi, T, Ticinesi, A, Nouvenne, A, Pirisi, M, Sola, D, Bellan, M, Quadri, R, Larovere, E, Novelli, M, Simeone, E, Scurti, R, Tolloso, F, Tarquini, R, Valoriani, A, Dolenti, S, Vannini, G, Volpi, R, Bocchi, P, Vignali, A, Harari, S, Lonati, C, Napoli, F, Aiello, I, Salvatore, T, Monaco, L, Ricozzi, C, Coviello, F, Catalini, C, Pilotto, A, Indiano, I, Gandolfo, F, Gonella, D, Nuti, R, Valenti, R, Ruvio, M, Cappelli, S, Palazzuoli, A, Durante, V, Tirotta, D, Eusebi, G, Tresoldi, M, Bozzolo, E, Damanti, S, Porta, M, Gino, M, Pari, B, Pace, E, Succurro E., Novella A., Nobili A., Giofre F., Arturi F., Sciacqua A., Andreozzi F., Pietrangelo A., Sesti G., Perticone F., Violi F., Corrao S., Marengoni A., Tettamanti M., Pasina L., Franchi C., Miglio G., Ardoino I., Cantiero S., Prisco D., Silvestri E., Emmi G., Bettiol A., Mattioli I., Mazzetti M., Biolo G., Zanetti M., Bartelloni G., Zaccari M., Chiuch M., Martini I., Pirro M., Lupattelli G., Bianconi V., Alcidi R., Giotta A., Mannarino M. R., Girelli D., Busti F., Marchi G., Barbagallo M., Dominguez L., Beneduce V., Cacioppo F., Natoli G., Mularo S., Raspanti M., Argano C., Cavallaro F., Zoli M., Orio G., Magnolfi E., Serafini G., Brunori M., Lazzari I., Simili A., Fabio G., De Amicis M. M., Luca G., Scaramellini N., Stefano V., Leoni S., Seghezzi S., Di Mauro A. D., Maira D., Mancarella M., Lucchi T., Clerici M., Bonini G., Conti F., Prolo S., Fabrizi M., Martelengo M., Vigani G., Nicolini P., Sabatino A., Miceli E., Pisati M., Pitotti L., Antoci V., Cambie G., Pontremoli R., Beccati V., Nobili G., Leoncini G., Alberto J., Cattaneo F., Anastasio L., Sofia L., Carbone M., Cipollone F., Rossi I., Valeriani E., D'Ardes D., Cipollone A., Esposito L., Sestili S., Angelucci E., Mancuso G., Calipari D., Bartone M., Manetti R., Sircana M., Berria M., Delitala A., Muscaritoli M., Molfino A., Petrillo E., Giorgi A., Gracin C., Imbimbo G., Romanelli G., Volpini A., Lucente D., Manzoni F., Pirozzi A., Zucchelli A., Geneletti T., Picardi A., Bellelli G., Corsi M., Antonucci C., Sidoli C., Principato G., Bonfanti A., Szabo H., Mazzola P., Piazzoli A., Tassone B., De Falco A. B. T., Negro E., Brenna M., Trotta L., Fabris F., Bertozzi I., Bogoni G., Prandini T., Ratti F., Zurlo C., Cerruti L., Cosi E., Reni E., Manfredini R., Boari B., Tiseo R., Savrie C., Fabbian F., Paolisso G., Catalano C., Meo I., Sabba C., Suppressa P., De Vincenzo G. M., Comitangelo A., Amoruso E., Custodero C., Re G., Barnaba I., Schilardi A., Fenoglio L., Falcetta A., D'Aniano S., Tiraboschi S., Cespiati A., Oberti G., Sigon G., Cinque F., Colavolpe L., Curra J., Alletto F., Benzoni G., Peyvandi F., Rossio R., Colombo G., Agosti P., Pagliaro E., Semproni E., Canetta C., Monzani V., Savojardo V., Ceriani G., Folli C., Tognin T., Purrello F., Pino A., Piro S., Rozzini R., Falanga L., Boffelli S., Ferrandina C., Mazzeo F., Spazzini E., Cono G., Cesaroni G., Perri L., Guasti L., Rotunno F., Castiglioni L., Maresca A., Squizzato A., Campiotti L., Grossi A., Dentali F., Behnke V., Perticone M., Maio R., Scozzafava A., Condoleo V., Clausi E., Armentaro G., Panza A., Stanghellini V., Ruggeri E., Vecchio S., Benzoni I., Minisola S., Colangelo L., Cilli M., Labbadia G., Pepe J., Castellino P., Zanoli L., Gaudio A., Xourafa A., Spichetti C., Torre S., Gennaro A., Ballestrero A., Ferrando F., Gonella R., Cerminara D., Setti P., Traversa C., Scarsi C., Famularo G., Tarsitani P., Morretti T., Aglitti A., Giacco S., Firinu D., Costanzo G., Chessa S., Montalto G., Licata A., Rizzo A., Corica F., Basile G., Catalano A., Bellone F., Principato C., Cocuzza A., Mecocci P., Ruggiero C., Boccardi V., Meschi T., Ticinesi A., Nouvenne A., Pirisi M., Sola D., Bellan M., Quadri R., Larovere E., Novelli M., Simeone E., Scurti R., Tolloso F., Tarquini R., Valoriani A., Dolenti S., Vannini G., Volpi R., Bocchi P., Vignali A., Harari S., Lonati C., Napoli F., Aiello I., Salvatore T., Monaco L., Ricozzi C., Coviello F., Catalini C., Pilotto A., Indiano I., Gandolfo F., Gonella D., Nuti R., Valenti R., Ruvio M., Cappelli S., Palazzuoli A., Durante V., Tirotta D., Eusebi G., Tresoldi M., Bozzolo E., Damanti S., Porta M., Gino M., Pari B., Pace E., Succurro E., Succurro, E, Novella, A, Nobili, A, Giofre, F, Arturi, F, Sciacqua, A, Andreozzi, F, Pietrangelo, A, Sesti, G, Perticone, F, Violi, F, Corrao, S, Marengoni, A, Tettamanti, M, Pasina, L, Franchi, C, Miglio, G, Ardoino, I, Cantiero, S, Prisco, D, Silvestri, E, Emmi, G, Bettiol, A, Mattioli, I, Mazzetti, M, Biolo, G, Zanetti, M, Bartelloni, G, Zaccari, M, Chiuch, M, Martini, I, Pirro, M, Lupattelli, G, Bianconi, V, Alcidi, R, Giotta, A, Mannarino, M, Girelli, D, Busti, F, Marchi, G, Barbagallo, M, Dominguez, L, Beneduce, V, Cacioppo, F, Natoli, G, Mularo, S, Raspanti, M, Argano, C, Cavallaro, F, Zoli, M, Orio, G, Magnolfi, E, Serafini, G, Brunori, M, Lazzari, I, Simili, A, Fabio, G, De Amicis, M, Luca, G, Scaramellini, N, Stefano, V, Leoni, S, Seghezzi, S, Di Mauro, A, Maira, D, Mancarella, M, Lucchi, T, Clerici, M, Bonini, G, Conti, F, Prolo, S, Fabrizi, M, Martelengo, M, Vigani, G, Nicolini, P, Sabatino, A, Miceli, E, Pisati, M, Pitotti, L, Antoci, V, Cambie, G, Pontremoli, R, Beccati, V, Nobili, G, Leoncini, G, Alberto, J, Cattaneo, F, Anastasio, L, Sofia, L, Carbone, M, Cipollone, F, Rossi, I, Valeriani, E, D'Ardes, D, Cipollone, A, Esposito, L, Sestili, S, Angelucci, E, Mancuso, G, Calipari, D, Bartone, M, Manetti, R, Sircana, M, Berria, M, Delitala, A, Muscaritoli, M, Molfino, A, Petrillo, E, Giorgi, A, Gracin, C, Imbimbo, G, Romanelli, G, Volpini, A, Lucente, D, Manzoni, F, Pirozzi, A, Zucchelli, A, Geneletti, T, Picardi, A, Bellelli, G, Corsi, M, Antonucci, C, Sidoli, C, Principato, G, Bonfanti, A, Szabo, H, Mazzola, P, Piazzoli, A, Tassone, B, De Falco, A, Negro, E, Brenna, M, Trotta, L, Fabris, F, Bertozzi, I, Bogoni, G, Prandini, T, Ratti, F, Zurlo, C, Cerruti, L, Cosi, E, Reni, E, Manfredini, R, Boari, B, Tiseo, R, Savrie, C, Fabbian, F, Paolisso, G, Catalano, C, Meo, I, Sabba, C, Suppressa, P, De Vincenzo, G, Comitangelo, A, Amoruso, E, Custodero, C, Re, G, Barnaba, I, Schilardi, A, Fenoglio, L, Falcetta, A, D'Aniano, S, Tiraboschi, S, Cespiati, A, Oberti, G, Sigon, G, Cinque, F, Colavolpe, L, Curra, J, Alletto, F, Benzoni, G, Peyvandi, F, Rossio, R, Colombo, G, Agosti, P, Pagliaro, E, Semproni, E, Canetta, C, Monzani, V, Savojardo, V, Ceriani, G, Folli, C, Tognin, T, Purrello, F, Pino, A, Piro, S, Rozzini, R, Falanga, L, Boffelli, S, Ferrandina, C, Mazzeo, F, Spazzini, E, Cono, G, Cesaroni, G, Perri, L, Guasti, L, Rotunno, F, Castiglioni, L, Maresca, A, Squizzato, A, Campiotti, L, Grossi, A, Dentali, F, Behnke, V, Perticone, M, Maio, R, Scozzafava, A, Condoleo, V, Clausi, E, Armentaro, G, Panza, A, Stanghellini, V, Ruggeri, E, Vecchio, S, Benzoni, I, Minisola, S, Colangelo, L, Cilli, M, Labbadia, G, Pepe, J, Castellino, P, Zanoli, L, Gaudio, A, Xourafa, A, Spichetti, C, Torre, S, Gennaro, A, Ballestrero, A, Ferrando, F, Gonella, R, Cerminara, D, Setti, P, Traversa, C, Scarsi, C, Famularo, G, Tarsitani, P, Morretti, T, Aglitti, A, Giacco, S, Firinu, D, Costanzo, G, Chessa, S, Montalto, G, Licata, A, Rizzo, A, Corica, F, Basile, G, Catalano, A, Bellone, F, Principato, C, Cocuzza, A, Mecocci, P, Ruggiero, C, Boccardi, V, Meschi, T, Ticinesi, A, Nouvenne, A, Pirisi, M, Sola, D, Bellan, M, Quadri, R, Larovere, E, Novelli, M, Simeone, E, Scurti, R, Tolloso, F, Tarquini, R, Valoriani, A, Dolenti, S, Vannini, G, Volpi, R, Bocchi, P, Vignali, A, Harari, S, Lonati, C, Napoli, F, Aiello, I, Salvatore, T, Monaco, L, Ricozzi, C, Coviello, F, Catalini, C, Pilotto, A, Indiano, I, Gandolfo, F, Gonella, D, Nuti, R, Valenti, R, Ruvio, M, Cappelli, S, Palazzuoli, A, Durante, V, Tirotta, D, Eusebi, G, Tresoldi, M, Bozzolo, E, Damanti, S, Porta, M, Gino, M, Pari, B, Pace, E, Succurro E., Novella A., Nobili A., Giofre F., Arturi F., Sciacqua A., Andreozzi F., Pietrangelo A., Sesti G., Perticone F., Violi F., Corrao S., Marengoni A., Tettamanti M., Pasina L., Franchi C., Miglio G., Ardoino I., Cantiero S., Prisco D., Silvestri E., Emmi G., Bettiol A., Mattioli I., Mazzetti M., Biolo G., Zanetti M., Bartelloni G., Zaccari M., Chiuch M., Martini I., Pirro M., Lupattelli G., Bianconi V., Alcidi R., Giotta A., Mannarino M. R., Girelli D., Busti F., Marchi G., Barbagallo M., Dominguez L., Beneduce V., Cacioppo F., Natoli G., Mularo S., Raspanti M., Argano C., Cavallaro F., Zoli M., Orio G., Magnolfi E., Serafini G., Brunori M., Lazzari I., Simili A., Fabio G., De Amicis M. M., Luca G., Scaramellini N., Stefano V., Leoni S., Seghezzi S., Di Mauro A. D., Maira D., Mancarella M., Lucchi T., Clerici M., Bonini G., Conti F., Prolo S., Fabrizi M., Martelengo M., Vigani G., Nicolini P., Sabatino A., Miceli E., Pisati M., Pitotti L., Antoci V., Cambie G., Pontremoli R., Beccati V., Nobili G., Leoncini G., Alberto J., Cattaneo F., Anastasio L., Sofia L., Carbone M., Cipollone F., Rossi I., Valeriani E., D'Ardes D., Cipollone A., Esposito L., Sestili S., Angelucci E., Mancuso G., Calipari D., Bartone M., Manetti R., Sircana M., Berria M., Delitala A., Muscaritoli M., Molfino A., Petrillo E., Giorgi A., Gracin C., Imbimbo G., Romanelli G., Volpini A., Lucente D., Manzoni F., Pirozzi A., Zucchelli A., Geneletti T., Picardi A., Bellelli G., Corsi M., Antonucci C., Sidoli C., Principato G., Bonfanti A., Szabo H., Mazzola P., Piazzoli A., Tassone B., De Falco A. B. T., Negro E., Brenna M., Trotta L., Fabris F., Bertozzi I., Bogoni G., Prandini T., Ratti F., Zurlo C., Cerruti L., Cosi E., Reni E., Manfredini R., Boari B., Tiseo R., Savrie C., Fabbian F., Paolisso G., Catalano C., Meo I., Sabba C., Suppressa P., De Vincenzo G. M., Comitangelo A., Amoruso E., Custodero C., Re G., Barnaba I., Schilardi A., Fenoglio L., Falcetta A., D'Aniano S., Tiraboschi S., Cespiati A., Oberti G., Sigon G., Cinque F., Colavolpe L., Curra J., Alletto F., Benzoni G., Peyvandi F., Rossio R., Colombo G., Agosti P., Pagliaro E., Semproni E., Canetta C., Monzani V., Savojardo V., Ceriani G., Folli C., Tognin T., Purrello F., Pino A., Piro S., Rozzini R., Falanga L., Boffelli S., Ferrandina C., Mazzeo F., Spazzini E., Cono G., Cesaroni G., Perri L., Guasti L., Rotunno F., Castiglioni L., Maresca A., Squizzato A., Campiotti L., Grossi A., Dentali F., Behnke V., Perticone M., Maio R., Scozzafava A., Condoleo V., Clausi E., Armentaro G., Panza A., Stanghellini V., Ruggeri E., Vecchio S., Benzoni I., Minisola S., Colangelo L., Cilli M., Labbadia G., Pepe J., Castellino P., Zanoli L., Gaudio A., Xourafa A., Spichetti C., Torre S., Gennaro A., Ballestrero A., Ferrando F., Gonella R., Cerminara D., Setti P., Traversa C., Scarsi C., Famularo G., Tarsitani P., Morretti T., Aglitti A., Giacco S., Firinu D., Costanzo G., Chessa S., Montalto G., Licata A., Rizzo A., Corica F., Basile G., Catalano A., Bellone F., Principato C., Cocuzza A., Mecocci P., Ruggiero C., Boccardi V., Meschi T., Ticinesi A., Nouvenne A., Pirisi M., Sola D., Bellan M., Quadri R., Larovere E., Novelli M., Simeone E., Scurti R., Tolloso F., Tarquini R., Valoriani A., Dolenti S., Vannini G., Volpi R., Bocchi P., Vignali A., Harari S., Lonati C., Napoli F., Aiello I., Salvatore T., Monaco L., Ricozzi C., Coviello F., Catalini C., Pilotto A., Indiano I., Gandolfo F., Gonella D., Nuti R., Valenti R., Ruvio M., Cappelli S., Palazzuoli A., Durante V., Tirotta D., Eusebi G., Tresoldi M., Bozzolo E., Damanti S., Porta M., Gino M., Pari B., and Pace E.

Abstract

In this article the names of a few collaborators and some data in Table 5 were missing. It has been corrected. The original article has been corrected.

Published
2023

39. Prescription appropriateness of anti-diabetes drugs in elderly patients hospitalized in a clinical setting: evidence from the REPOSI Register

Author

Succurro, E, Novella, A, Nobili, A, Giofre, F, Arturi, F, Sciacqua, A, Andreozzi, F, Pietrangelo, A, Sesti, G, Perticone, F, Violi, F, Corrao, S, Marengoni, A, Tettamanti, M, Pasina, L, Franchi, C, Miglio, G, Ardoino, I, Cantiero, S, Prisco, D, Silvestri, E, Emmi, G, Bettiol, A, Mattioli, I, Mazzetti, M, Biolo, G, Zanetti, M, Bartelloni, G, Zaccari, M, Chiuch, M, Martini, I, Pirro, M, Lupattelli, G, Bianconi, V, Alcidi, R, Giotta, A, Mannarino, M, Girelli, D, Busti, F, Marchi, G, Barbagallo, M, Dominguez, L, Beneduce, V, Cacioppo, F, Natoli, G, Mularo, S, Raspanti, M, Argano, C, Cavallaro, F, Zoli, M, Orio, G, Magnolfi, E, Serafini, G, Brunori, M, Lazzari, I, Simili, A, Fabio, G, De Amicis, M, Luca, G, Scaramellini, N, Stefano, V, Leoni, S, Seghezzi, S, Di Mauro, A, Maira, D, Mancarella, M, Lucchi, T, Clerici, M, Bonini, G, Conti, F, Prolo, S, Fabrizi, M, Martelengo, M, Vigani, G, Nicolini, P, Sabatino, A, Miceli, E, Pisati, M, Pitotti, L, Antoci, V, Cambie, G, Pontremoli, R, Beccati, V, Nobili, G, Leoncini, G, Alberto, J, Cattaneo, F, Anastasio, L, Sofia, L, Carbone, M, Cipollone, F, Rossi, I, Valeriani, E, D'Ardes, D, Cipollone, A, Esposito, L, Sestili, S, Angelucci, E, Mancuso, G, Calipari, D, Bartone, M, Manetti, R, Sircana, M, Berria, M, Delitala, A, Muscaritoli, M, Molfino, A, Petrillo, E, Giorgi, A, Gracin, C, Imbimbo, G, Romanelli, G, Volpini, A, Lucente, D, Manzoni, F, Pirozzi, A, Zucchelli, A, Geneletti, T, Picardi, A, Bellelli, G, Corsi, M, Antonucci, C, Sidoli, C, Principato, G, Bonfanti, A, Szabo, H, Mazzola, P, Piazzoli, A, Tassone, B, De Falco, A, Negro, E, Brenna, M, Trotta, L, Fabris, F, Bertozzi, I, Bogoni, G, Prandini, T, Ratti, F, Zurlo, C, Cerruti, L, Cosi, E, Reni, E, Manfredini, R, Boari, B, Tiseo, R, Savrie, C, Fabbian, F, Paolisso, G, Catalano, C, Meo, I, Sabba, C, Suppressa, P, De Vincenzo, G, Comitangelo, A, Amoruso, E, Custodero, C, Re, G, Barnaba, I, Schilardi, A, Fenoglio, L, Falcetta, A, D'Aniano, S, Tiraboschi, S, Cespiati, A, Oberti, G, Sigon, G, Cinque, F, Colavolpe, L, Curra, J, Alletto, F, Benzoni, G, Peyvandi, F, Rossio, R, Colombo, G, Agosti, P, Pagliaro, E, Semproni, E, Canetta, C, Monzani, V, Savojardo, V, Ceriani, G, Folli, C, Tognin, T, Purrello, F, Pino, A, Piro, S, Rozzini, R, Falanga, L, Boffelli, S, Ferrandina, C, Mazzeo, F, Spazzini, E, Cono, G, Cesaroni, G, Perri, L, Guasti, L, Rotunno, F, Castiglioni, L, Maresca, A, Squizzato, A, Campiotti, L, Grossi, A, Dentali, F, Behnke, V, Perticone, M, Maio, R, Scozzafava, A, Condoleo, V, Clausi, E, Armentaro, G, Panza, A, Stanghellini, V, Ruggeri, E, Vecchio, S, Benzoni, I, Minisola, S, Colangelo, L, Cilli, M, Labbadia, G, Pepe, J, Castellino, P, Zanoli, L, Gaudio, A, Xourafa, A, Spichetti, C, Torre, S, Gennaro, A, Ballestrero, A, Ferrando, F, Gonella, R, Cerminara, D, Setti, P, Traversa, C, Scarsi, C, Famularo, G, Tarsitani, P, Morretti, T, Aglitti, A, Giacco, S, Firinu, D, Costanzo, G, Chessa, S, Montalto, G, Licata, A, Rizzo, A, Corica, F, Basile, G, Catalano, A, Bellone, F, Principato, C, Cocuzza, A, Mecocci, P, Ruggiero, C, Boccardi, V, Meschi, T, Ticinesi, A, Nouvenne, A, Pirisi, M, Sola, D, Bellan, M, Quadri, R, Larovere, E, Novelli, M, Simeone, E, Scurti, R, Tolloso, F, Tarquini, R, Valoriani, A, Dolenti, S, Vannini, G, Volpi, R, Bocchi, P, Vignali, A, Harari, S, Lonati, C, Napoli, F, Aiello, I, Salvatore, T, Monaco, L, Ricozzi, C, Coviello, F, Catalini, C, Pilotto, A, Indiano, I, Gandolfo, F, Gonella, D, Nuti, R, Valenti, R, Ruvio, M, Cappelli, S, Palazzuoli, A, Durante, V, Tirotta, D, Eusebi, G, Tresoldi, M, Bozzolo, E, Damanti, S, Porta, M, Gino, M, Pari, B, Pace, E, Succurro E., Novella A., Nobili A., Giofre F., Arturi F., Sciacqua A., Andreozzi F., Pietrangelo A., Sesti G., Perticone F., Violi F., Corrao S., Marengoni A., Tettamanti M., Pasina L., Franchi C., Miglio G., Ardoino I., Cantiero S., Prisco D., Silvestri E., Emmi G., Bettiol A., Mattioli I., Mazzetti M., Biolo G., Zanetti M., Bartelloni G., Zaccari M., Chiuch M., Martini I., Pirro M., Lupattelli G., Bianconi V., Alcidi R., Giotta A., Mannarino M. R., Girelli D., Busti F., Marchi G., Barbagallo M., Dominguez L., Beneduce V., Cacioppo F., Natoli G., Mularo S., Raspanti M., Argano C., Cavallaro F., Zoli M., Orio G., Magnolfi E., Serafini G., Brunori M., Lazzari I., Simili A., Fabio G., De Amicis M. M., Luca G., Scaramellini N., Stefano V., Leoni S., Seghezzi S., Di Mauro A. D., Maira D., Mancarella M., Lucchi T., Clerici M., Bonini G., Conti F., Prolo S., Fabrizi M., Martelengo M., Vigani G., Nicolini P., Sabatino A., Miceli E., Pisati M., Pitotti L., Antoci V., Cambie G., Pontremoli R., Beccati V., Nobili G., Leoncini G., Alberto J., Cattaneo F., Anastasio L., Sofia L., Carbone M., Cipollone F., Rossi I., Valeriani E., D'Ardes D., Cipollone A., Esposito L., Sestili S., Angelucci E., Mancuso G., Calipari D., Bartone M., Manetti R., Sircana M., Berria M., Delitala A., Muscaritoli M., Molfino A., Petrillo E., Giorgi A., Gracin C., Imbimbo G., Romanelli G., Volpini A., Lucente D., Manzoni F., Pirozzi A., Zucchelli A., Geneletti T., Picardi A., Bellelli G., Corsi M., Antonucci C., Sidoli C., Principato G., Bonfanti A., Szabo H., Mazzola P., Piazzoli A., Tassone B., De Falco A. B. T., Negro E., Brenna M., Trotta L., Fabris F., Bertozzi I., Bogoni G., Prandini T., Ratti F., Zurlo C., Cerruti L., Cosi E., Reni E., Manfredini R., Boari B., Tiseo R., Savrie C., Fabbian F., Paolisso G., Catalano C., Meo I., Sabba C., Suppressa P., De Vincenzo G. M., Comitangelo A., Amoruso E., Custodero C., Re G., Barnaba I., Schilardi A., Fenoglio L., Falcetta A., D'Aniano S., Tiraboschi S., Cespiati A., Oberti G., Sigon G., Cinque F., Colavolpe L., Curra J., Alletto F., Benzoni G., Peyvandi F., Rossio R., Colombo G., Agosti P., Pagliaro E., Semproni E., Canetta C., Monzani V., Savojardo V., Ceriani G., Folli C., Tognin T., Purrello F., Pino A., Piro S., Rozzini R., Falanga L., Boffelli S., Ferrandina C., Mazzeo F., Spazzini E., Cono G., Cesaroni G., Perri L., Guasti L., Rotunno F., Castiglioni L., Maresca A., Squizzato A., Campiotti L., Grossi A., Dentali F., Behnke V., Perticone M., Maio R., Scozzafava A., Condoleo V., Clausi E., Armentaro G., Panza A., Stanghellini V., Ruggeri E., Vecchio S., Benzoni I., Minisola S., Colangelo L., Cilli M., Labbadia G., Pepe J., Castellino P., Zanoli L., Gaudio A., Xourafa A., Spichetti C., Torre S., Gennaro A., Ballestrero A., Ferrando F., Gonella R., Cerminara D., Setti P., Traversa C., Scarsi C., Famularo G., Tarsitani P., Morretti T., Aglitti A., Giacco S., Firinu D., Costanzo G., Chessa S., Montalto G., Licata A., Rizzo A., Corica F., Basile G., Catalano A., Bellone F., Principato C., Cocuzza A., Mecocci P., Ruggiero C., Boccardi V., Meschi T., Ticinesi A., Nouvenne A., Pirisi M., Sola D., Bellan M., Quadri R., Larovere E., Novelli M., Simeone E., Scurti R., Tolloso F., Tarquini R., Valoriani A., Dolenti S., Vannini G., Volpi R., Bocchi P., Vignali A., Harari S., Lonati C., Napoli F., Aiello I., Salvatore T., Monaco L., Ricozzi C., Coviello F., Catalini C., Pilotto A., Indiano I., Gandolfo F., Gonella D., Nuti R., Valenti R., Ruvio M., Cappelli S., Palazzuoli A., Durante V., Tirotta D., Eusebi G., Tresoldi M., Bozzolo E., Damanti S., Porta M., Gino M., Pari B., Pace E., Succurro, E, Novella, A, Nobili, A, Giofre, F, Arturi, F, Sciacqua, A, Andreozzi, F, Pietrangelo, A, Sesti, G, Perticone, F, Violi, F, Corrao, S, Marengoni, A, Tettamanti, M, Pasina, L, Franchi, C, Miglio, G, Ardoino, I, Cantiero, S, Prisco, D, Silvestri, E, Emmi, G, Bettiol, A, Mattioli, I, Mazzetti, M, Biolo, G, Zanetti, M, Bartelloni, G, Zaccari, M, Chiuch, M, Martini, I, Pirro, M, Lupattelli, G, Bianconi, V, Alcidi, R, Giotta, A, Mannarino, M, Girelli, D, Busti, F, Marchi, G, Barbagallo, M, Dominguez, L, Beneduce, V, Cacioppo, F, Natoli, G, Mularo, S, Raspanti, M, Argano, C, Cavallaro, F, Zoli, M, Orio, G, Magnolfi, E, Serafini, G, Brunori, M, Lazzari, I, Simili, A, Fabio, G, De Amicis, M, Luca, G, Scaramellini, N, Stefano, V, Leoni, S, Seghezzi, S, Di Mauro, A, Maira, D, Mancarella, M, Lucchi, T, Clerici, M, Bonini, G, Conti, F, Prolo, S, Fabrizi, M, Martelengo, M, Vigani, G, Nicolini, P, Sabatino, A, Miceli, E, Pisati, M, Pitotti, L, Antoci, V, Cambie, G, Pontremoli, R, Beccati, V, Nobili, G, Leoncini, G, Alberto, J, Cattaneo, F, Anastasio, L, Sofia, L, Carbone, M, Cipollone, F, Rossi, I, Valeriani, E, D'Ardes, D, Cipollone, A, Esposito, L, Sestili, S, Angelucci, E, Mancuso, G, Calipari, D, Bartone, M, Manetti, R, Sircana, M, Berria, M, Delitala, A, Muscaritoli, M, Molfino, A, Petrillo, E, Giorgi, A, Gracin, C, Imbimbo, G, Romanelli, G, Volpini, A, Lucente, D, Manzoni, F, Pirozzi, A, Zucchelli, A, Geneletti, T, Picardi, A, Bellelli, G, Corsi, M, Antonucci, C, Sidoli, C, Principato, G, Bonfanti, A, Szabo, H, Mazzola, P, Piazzoli, A, Tassone, B, De Falco, A, Negro, E, Brenna, M, Trotta, L, Fabris, F, Bertozzi, I, Bogoni, G, Prandini, T, Ratti, F, Zurlo, C, Cerruti, L, Cosi, E, Reni, E, Manfredini, R, Boari, B, Tiseo, R, Savrie, C, Fabbian, F, Paolisso, G, Catalano, C, Meo, I, Sabba, C, Suppressa, P, De Vincenzo, G, Comitangelo, A, Amoruso, E, Custodero, C, Re, G, Barnaba, I, Schilardi, A, Fenoglio, L, Falcetta, A, D'Aniano, S, Tiraboschi, S, Cespiati, A, Oberti, G, Sigon, G, Cinque, F, Colavolpe, L, Curra, J, Alletto, F, Benzoni, G, Peyvandi, F, Rossio, R, Colombo, G, Agosti, P, Pagliaro, E, Semproni, E, Canetta, C, Monzani, V, Savojardo, V, Ceriani, G, Folli, C, Tognin, T, Purrello, F, Pino, A, Piro, S, Rozzini, R, Falanga, L, Boffelli, S, Ferrandina, C, Mazzeo, F, Spazzini, E, Cono, G, Cesaroni, G, Perri, L, Guasti, L, Rotunno, F, Castiglioni, L, Maresca, A, Squizzato, A, Campiotti, L, Grossi, A, Dentali, F, Behnke, V, Perticone, M, Maio, R, Scozzafava, A, Condoleo, V, Clausi, E, Armentaro, G, Panza, A, Stanghellini, V, Ruggeri, E, Vecchio, S, Benzoni, I, Minisola, S, Colangelo, L, Cilli, M, Labbadia, G, Pepe, J, Castellino, P, Zanoli, L, Gaudio, A, Xourafa, A, Spichetti, C, Torre, S, Gennaro, A, Ballestrero, A, Ferrando, F, Gonella, R, Cerminara, D, Setti, P, Traversa, C, Scarsi, C, Famularo, G, Tarsitani, P, Morretti, T, Aglitti, A, Giacco, S, Firinu, D, Costanzo, G, Chessa, S, Montalto, G, Licata, A, Rizzo, A, Corica, F, Basile, G, Catalano, A, Bellone, F, Principato, C, Cocuzza, A, Mecocci, P, Ruggiero, C, Boccardi, V, Meschi, T, Ticinesi, A, Nouvenne, A, Pirisi, M, Sola, D, Bellan, M, Quadri, R, Larovere, E, Novelli, M, Simeone, E, Scurti, R, Tolloso, F, Tarquini, R, Valoriani, A, Dolenti, S, Vannini, G, Volpi, R, Bocchi, P, Vignali, A, Harari, S, Lonati, C, Napoli, F, Aiello, I, Salvatore, T, Monaco, L, Ricozzi, C, Coviello, F, Catalini, C, Pilotto, A, Indiano, I, Gandolfo, F, Gonella, D, Nuti, R, Valenti, R, Ruvio, M, Cappelli, S, Palazzuoli, A, Durante, V, Tirotta, D, Eusebi, G, Tresoldi, M, Bozzolo, E, Damanti, S, Porta, M, Gino, M, Pari, B, Pace, E, Succurro E., Novella A., Nobili A., Giofre F., Arturi F., Sciacqua A., Andreozzi F., Pietrangelo A., Sesti G., Perticone F., Violi F., Corrao S., Marengoni A., Tettamanti M., Pasina L., Franchi C., Miglio G., Ardoino I., Cantiero S., Prisco D., Silvestri E., Emmi G., Bettiol A., Mattioli I., Mazzetti M., Biolo G., Zanetti M., Bartelloni G., Zaccari M., Chiuch M., Martini I., Pirro M., Lupattelli G., Bianconi V., Alcidi R., Giotta A., Mannarino M. R., Girelli D., Busti F., Marchi G., Barbagallo M., Dominguez L., Beneduce V., Cacioppo F., Natoli G., Mularo S., Raspanti M., Argano C., Cavallaro F., Zoli M., Orio G., Magnolfi E., Serafini G., Brunori M., Lazzari I., Simili A., Fabio G., De Amicis M. M., Luca G., Scaramellini N., Stefano V., Leoni S., Seghezzi S., Di Mauro A. D., Maira D., Mancarella M., Lucchi T., Clerici M., Bonini G., Conti F., Prolo S., Fabrizi M., Martelengo M., Vigani G., Nicolini P., Sabatino A., Miceli E., Pisati M., Pitotti L., Antoci V., Cambie G., Pontremoli R., Beccati V., Nobili G., Leoncini G., Alberto J., Cattaneo F., Anastasio L., Sofia L., Carbone M., Cipollone F., Rossi I., Valeriani E., D'Ardes D., Cipollone A., Esposito L., Sestili S., Angelucci E., Mancuso G., Calipari D., Bartone M., Manetti R., Sircana M., Berria M., Delitala A., Muscaritoli M., Molfino A., Petrillo E., Giorgi A., Gracin C., Imbimbo G., Romanelli G., Volpini A., Lucente D., Manzoni F., Pirozzi A., Zucchelli A., Geneletti T., Picardi A., Bellelli G., Corsi M., Antonucci C., Sidoli C., Principato G., Bonfanti A., Szabo H., Mazzola P., Piazzoli A., Tassone B., De Falco A. B. T., Negro E., Brenna M., Trotta L., Fabris F., Bertozzi I., Bogoni G., Prandini T., Ratti F., Zurlo C., Cerruti L., Cosi E., Reni E., Manfredini R., Boari B., Tiseo R., Savrie C., Fabbian F., Paolisso G., Catalano C., Meo I., Sabba C., Suppressa P., De Vincenzo G. M., Comitangelo A., Amoruso E., Custodero C., Re G., Barnaba I., Schilardi A., Fenoglio L., Falcetta A., D'Aniano S., Tiraboschi S., Cespiati A., Oberti G., Sigon G., Cinque F., Colavolpe L., Curra J., Alletto F., Benzoni G., Peyvandi F., Rossio R., Colombo G., Agosti P., Pagliaro E., Semproni E., Canetta C., Monzani V., Savojardo V., Ceriani G., Folli C., Tognin T., Purrello F., Pino A., Piro S., Rozzini R., Falanga L., Boffelli S., Ferrandina C., Mazzeo F., Spazzini E., Cono G., Cesaroni G., Perri L., Guasti L., Rotunno F., Castiglioni L., Maresca A., Squizzato A., Campiotti L., Grossi A., Dentali F., Behnke V., Perticone M., Maio R., Scozzafava A., Condoleo V., Clausi E., Armentaro G., Panza A., Stanghellini V., Ruggeri E., Vecchio S., Benzoni I., Minisola S., Colangelo L., Cilli M., Labbadia G., Pepe J., Castellino P., Zanoli L., Gaudio A., Xourafa A., Spichetti C., Torre S., Gennaro A., Ballestrero A., Ferrando F., Gonella R., Cerminara D., Setti P., Traversa C., Scarsi C., Famularo G., Tarsitani P., Morretti T., Aglitti A., Giacco S., Firinu D., Costanzo G., Chessa S., Montalto G., Licata A., Rizzo A., Corica F., Basile G., Catalano A., Bellone F., Principato C., Cocuzza A., Mecocci P., Ruggiero C., Boccardi V., Meschi T., Ticinesi A., Nouvenne A., Pirisi M., Sola D., Bellan M., Quadri R., Larovere E., Novelli M., Simeone E., Scurti R., Tolloso F., Tarquini R., Valoriani A., Dolenti S., Vannini G., Volpi R., Bocchi P., Vignali A., Harari S., Lonati C., Napoli F., Aiello I., Salvatore T., Monaco L., Ricozzi C., Coviello F., Catalini C., Pilotto A., Indiano I., Gandolfo F., Gonella D., Nuti R., Valenti R., Ruvio M., Cappelli S., Palazzuoli A., Durante V., Tirotta D., Eusebi G., Tresoldi M., Bozzolo E., Damanti S., Porta M., Gino M., Pari B., and Pace E.

Abstract

Diabetes is an increasing global health burden with the highest prevalence (24.0%) observed in elderly people. Older diabetic adults have a greater risk of hospitalization and several geriatric syndromes than older nondiabetic adults. For these conditions, special care is required in prescribing therapies including anti- diabetes drugs. Aim of this study was to evaluate the appropriateness and the adherence to safety recommendations in the prescriptions of glucose-lowering drugs in hospitalized elderly patients with diabetes. Data for this cross-sectional study were obtained from the REgistro POliterapie–Società Italiana Medicina Interna (REPOSI) that collected clinical information on patients aged ≥ 65 years acutely admitted to Italian internal medicine and geriatric non-intensive care units (ICU) from 2010 up to 2019. Prescription appropriateness was assessed according to the 2019 AGS Beers Criteria and anti-diabetes drug data sheets.Among 5349 patients, 1624 (30.3%) had diagnosis of type 2 diabetes. At admission, 37.7% of diabetic patients received treatment with metformin, 37.3% insulin therapy, 16.4% sulfonylureas, and 11.4% glinides. Surprisingly, only 3.1% of diabetic patients were treated with new classes of anti- diabetes drugs. According to prescription criteria, at admission 15.4% of patients treated with metformin and 2.6% with sulfonylureas received inappropriately these treatments. At discharge, the inappropriateness of metformin therapy decreased (10.2%, P < 0.0001). According to Beers criteria, the inappropriate prescriptions of sulfonylureas raised to 29% both at admission and at discharge. This study shows a poor adherence to current guidelines on diabetes management in hospitalized elderly people with a high prevalence of inappropriate use of sulfonylureas according to the Beers criteria.

Published
2023

40. Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers

Author

Pauthner, Matthias G., Nkolola, Joseph P., Havenar-Daughton, Colin, Murrell, Ben, Reiss, Samantha M., Bastidas, Raiza, Prévost, Jérémie, Nedellec, Rebecca, von Bredow, Benjamin, Abbink, Peter, Cottrell, Christopher A., Kulp, Daniel W., Tokatlian, Talar, Nogal, Bartek, Bianchi, Matteo, Li, Hui, Lee, Jeong Hyun, Butera, Salvatore T., Evans, David T., Hangartner, Lars, Finzi, Andrés, Wilson, Ian A., Wyatt, Richard T., Irvine, Darrell J., Schief, William R., Ward, Andrew B., Sanders, Rogier W., Crotty, Shane, Shaw, George M., Barouch, Dan H., and Burton, Dennis R.

Published
2019
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41. Short-Term Dietary Restriction Potentiates an Anti-Inflammatory Circulating Mucosal-Associated Invariant T-Cell Response.

Author

Fazzone, Brian, Anderson, Erik M., Rozowsky, Jared M., Yu, Xuanxuan, O'Malley, Kerri A., Robinson, Scott, Scali, Salvatore T., Cai, Guoshuai, and Berceli, Scott A.

Abstract

Short-term protein-calorie dietary restriction (StDR) is a promising preoperative strategy for modulating postoperative inflammation. We have previously shown marked gut microbial activity during StDR, but relationships between StDR, the gut microbiome, and systemic immunity remain poorly understood. Mucosal-associated invariant T-cells (MAITs) are enriched on mucosal surfaces and in circulation, bridge innate and adaptive immunity, are sensitive to gut microbial changes, and may mediate systemic responses to StDR. Herein, we characterized the MAIT transcriptomic response to StDR using single-cell RNA sequencing of human PBMCs and evaluated gut microbial species-level changes through sequencing of stool samples. Healthy volunteers underwent 4 days of DR during which blood and stool samples were collected before, during, and after DR. MAITs composed 2.4% of PBMCs. More MAIT genes were differentially downregulated during DR, particularly genes associated with MAIT activation (CD69), regulation of pro-inflammatory signaling (IL1, IL6, IL10, TNFα), and T-cell co-stimulation (CD40/CD40L, CD28), whereas genes associated with anti-inflammatory IL10 signaling were upregulated. Stool analysis showed a decreased abundance of multiple MAIT-stimulating Bacteroides species during DR. The analyses suggest that StDR potentiates an anti-inflammatory MAIT immunophenotype through modulation of TCR-dependent signaling, potentially secondary to gut microbial species-level changes. [ABSTRACT FROM AUTHOR]

Published
2024
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44. Single-Nuclei RNA-Sequencing of the Gastrocnemius Muscle in Peripheral Artery Disease

Author

Pass, Caroline, primary, Palzkill, Victoria, additional, Tan, Jianna, additional, Kim, Kyoungrae, additional, Thome, Trace, additional, Yang, Qingping, additional, Fazzone, Brian, additional, Robinson, Scott T., additional, O’Malley, Kerri A., additional, Yue, Feng, additional, Scali, Salvatore T., additional, Berceli, Scott A., additional, and Ryan, Terence E., additional

Published
2023
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47. Venoarterial Extracorporeal Membrane Oxygenation for "Protected" Percutaneous Coronary Intervention Secondary to Refractory Polymorphic Ventricular Tachycardia and Cardiac Arrest.

Author

Phillips, Jordan D., Spratt, John R., Choi, Calvin Y., Scali, Salvatore T., and Maybauer, Marc O.

Subjects
RETURN of spontaneous circulation, ARTIFICIAL blood circulation, PERCUTANEOUS coronary intervention, EXTRACORPOREAL membrane oxygenation, VENTRICULAR tachycardia, CARDIOGENIC shock
Abstract

We present a case of cardiogenic shock secondary to refractory polymorphic ventricular tachycardia associated with coronary ischemia resulting in cardiac arrest. Following the return of spontaneous circulation, the patient was cannulated for peripheral venoarterial extracorporeal membrane oxygenation (V-A ECMO) in anticipation of high-risk "protected" percutaneous coronary intervention (PCI). Under full V-A ECMO support, inotropes and vasopressors were weaned off, and the patient underwent uneventful PCI of left circumflex and obtuse marginal lesions. After 48 hours, the patient was decannulated and could be discharged home alive 16 days after his initial cardiac arrest. [ABSTRACT FROM AUTHOR]

Published
2024
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48. Metabolomic profiling reveals muscle metabolic changes following iliac arteriovenous fistula creation in mice

Author

Ram B. Khattri, Kyoungrae Kim, Erik M. Anderson, Brian Fazzone, Kenneth C. Harland, Qiongyao Hu, Victoria R. Palzkill, Tomas A. Cort, Kerri A. O’Malley, Scott A. Berceli, Salvatore T. Scali, and Terence E. Ryan

Subjects
Mice, Adenosine Triphosphate, Arteriovenous Shunt, Surgical, Physiology, Renal Dialysis, Adenine, Muscles, Arteriovenous Fistula, Animals, Kidney Failure, Chronic, Renal Insufficiency, Chronic, Creatine, Adenosine Monophosphate
Abstract

End-stage kidney disease, the most advanced stage of chronic kidney disease (CKD), requires renal replacement therapy or kidney transplant to sustain life. To accomplish durable dialysis access, the creation of an arteriovenous fistula (AVF) has emerged as a preferred approach. Unfortunately, a significant proportion of patients that receive an AVF experience some form of hand dysfunction; however, the mechanisms underlying these side effects are not understood. In this study, we used nuclear magnetic resonance spectroscopy to investigate the muscle metabolome following iliac AVF placement in mice with CKD. To induce CKD, C57BL6J mice were fed an adenine-supplemented diet for 3 wk and then randomized to receive AVF or sham surgery. Two weeks following surgery, the quadriceps muscles were rapidly dissected and snap frozen for metabolite extraction and subsequent nuclear magnetic resonance analysis. Principal component analysis demonstrated clear separation between groups, confirming a unique metabolome in mice that received an AVF. AVF creation resulted in reduced levels of creatine, ATP, and AMP as well as increased levels of IMP and several tricarboxylic acid cycle metabolites suggesting profound energetic stress. Pearson correlation and multiple linear regression analyses identified several metabolites that were strongly linked to measures of limb function (grip strength, gait speed, and mitochondrial respiration). In summary, AVF creation generates a unique metabolome profile in the distal skeletal muscle indicative of an energetic crisis and myosteatosis.

Published
2023

50. Assessing the quality of reporting of studies using Vascular Quality Initiative (VQI) data

Author

Amin A. Mirzaie, Amanda M. Delgado, Danielle T. DuPuis, Bankole Olowofela, Scott A. Berceli, Salvatore T. Scali, Thomas S. Huber, Gilbert R. Upchurch, and Samir K. Shah

Subjects
Surgery, Cardiology and Cardiovascular Medicine
Abstract

The Society for Vascular Surgery Vascular Quality Initiative (VQI) has become an increasingly popular data source for retrospective observational vascular surgery studies. There are published guidelines on the reporting of data in such studies to promote transparency and rigor, but these have not been used to evaluate studies using VQI data. Our objective was to appraise the methodological reporting quality of studies using VQI data by evaluating their adherence to these guidelines.The Society for Vascular Surgery VQI publication repository was queried for all articles published in 2020. The REporting of studies Conducted using Observational Routinely-collected Health Data (RECORD) statement and the Journal of American Medical Association-Surgical Section (JAMA-Surgery) checklist were utilized to assess the quality of each article's reporting. Five and three items from the RECORD statement and JAMA-Surgery checklist were excluded, respectively, because they were either inapplicable or nonassessable. Journal impact factor (IF) was queried for each article to elucidate any difference in reporting standards between high and low IF journals.Ninety studies were identified and analyzed. The median score on the RECORD checklist was 6 (of 8). The most commonly missed item was discussing data cleaning methods (93% missed). The median score on the JAMA-Surgery checklist was 3 (of 7). The most commonly missed items were the identification of competing risks (98% missed), the use of a flow chart to clearly define sample exclusion and inclusion criteria (84% missed), and the inclusion of a solid research question and hypothesis (81% missed). There were no differences in JAMA-Surgery checklist or RECORD statement median scores among studies published in low vs high IF journals.Studies using VQI data demonstrate a poor to moderate adherence to reporting standards. Key areas for improvement in research reporting include articulating a clear hypothesis, using flow charts to clearly define inclusion and exclusion criteria, identifying competing risks, and discussing data cleaning methods. Additionally, future efforts should center on creating tailored instruments to better guide reporting in studies using VQI data.

Published
2023
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