350 results on '"Salum, Giovanni A"'
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2. Translation and cross-cultural adaptation of seventeen widely-used assessment instruments for child and adolescent mental health in Greece
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Karagiorga, Vasiliki Eirini, Schafer, Julia Luiza, Marchionatti, Lauro Estivalete, Caye, Arthur, Serdari, Aspasia, Kotsis, Konstantinos, Basta, Maria, Balikou, Panagiota, Kapsimalli, Efstathia, Mitropoulou, Andromachi, Klavdianou, Nikanthi, Zeleni, Domna, Mitroulaki, Sotiria, Botzaki, Anna, Gerostergios, Giorgos, Samiotakis, Giorgos, Simioni, André, Georgiades, Katholiki, Salum, Giovanni Abrahão, and Koumoula, Anastasia
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- 2024
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3. Volume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group.
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Groenewold, Nynke, Bas-Hoogendam, Janna, Amod, Alyssa, Laansma, Max, Van Velzen, Laura, Aghajani, Moji, Hilbert, Kevin, Oh, Hyuntaek, Salas, Ramiro, Jackowski, Andrea, Pan, Pedro, Salum, Giovanni, Blair, James, Blair, Karina, Hirsch, Joy, Pantazatos, Spiro, Schneier, Franklin, Talati, Ardesheer, Roelofs, Karin, Volman, Inge, Blanco-Hinojo, Laura, Cardoner, Narcís, Pujol, Jesus, Beesdo-Baum, Katja, Ching, Christopher, Thomopoulos, Sophia, Jansen, Andreas, Kircher, Tilo, Krug, Axel, Nenadić, Igor, Stein, Frederike, Dannlowski, Udo, Grotegerd, Dominik, Lemke, Hannah, Meinert, Susanne, Winter, Alexandra, Erb, Michael, Kreifelts, Benjamin, Gong, Qiyong, Lui, Su, Zhu, Fei, Mwangi, Benson, Soares, Jair, Wu, Mon-Ju, Bayram, Ali, Canli, Mesut, Tükel, Raşit, Westenberg, P, Heeren, Alexandre, Cremers, Henk, Hofmann, David, Straube, Thomas, Doruyter, Alexander, Lochner, Christine, Peterburs, Jutta, Van Tol, Marie-José, Gur, Raquel, Kaczkurkin, Antonia, Larsen, Bart, Satterthwaite, Theodore, Filippi, Courtney, Gold, Andrea, Harrewijn, Anita, Zugman, André, Bülow, Robin, Grabe, Hans, Völzke, Henry, Wittfeld, Katharina, Böhnlein, Joscha, Dohm, Katharina, Kugel, Harald, Schrammen, Elisabeth, Zwanzger, Peter, Leehr, Elisabeth, Sindermann, Lisa, Ball, Tali, Fonzo, Gregory, Paulus, Martin, Stein, Murray, Klumpp, Heide, Phan, K, Furmark, Tomas, Månsson, Kristoffer, Manzouri, Amirhossein, Avery, Suzanne, Blackford, Jennifer, Clauss, Jacqueline, Feola, Brandee, Harper, Jennifer, Sylvester, Chad, Lueken, Ulrike, Veltman, Dick, Winkler, Anderson, Jahanshad, Neda, Pine, Daniel, Thompson, Paul, Stein, Dan, Van der Wee, Nic, and Simmons, Alan
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Adult ,Adolescent ,Humans ,Phobia ,Social ,Magnetic Resonance Imaging ,Brain ,Anxiety ,Neuroimaging - Abstract
There is limited convergence in neuroimaging investigations into volumes of subcortical brain regions in social anxiety disorder (SAD). The inconsistent findings may arise from variations in methodological approaches across studies, including sample selection based on age and clinical characteristics. The ENIGMA-Anxiety Working Group initiated a global mega-analysis to determine whether differences in subcortical volumes can be detected in adults and adolescents with SAD relative to healthy controls. Volumetric data from 37 international samples with 1115 SAD patients and 2775 controls were obtained from ENIGMA-standardized protocols for image segmentation and quality assurance. Linear mixed-effects analyses were adjusted for comparisons across seven subcortical regions in each hemisphere using family-wise error (FWE)-correction. Mixed-effects d effect sizes were calculated. In the full sample, SAD patients showed smaller bilateral putamen volume than controls (left: d = -0.077, pFWE = 0.037; right: d = -0.104, pFWE = 0.001), and a significant interaction between SAD and age was found for the left putamen (r = -0.034, pFWE = 0.045). Smaller bilateral putamen volumes (left: d = -0.141, pFWE
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- 2023
4. Alterations in microRNA of extracellular vesicles associated with major depression, attention-deficit/hyperactivity and anxiety disorders in adolescents
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Honorato-Mauer, Jessica, Xavier, Gabriela, Ota, Vanessa Kiyomi, Chehimi, Samar Nasser, Mafra, Fernanda, Cuóco, Cássia, Ito, Lucas Toshio, Ormond, Rafaella, Asprino, Paula Fontes, Oliveira, Adrielle, Bugiga, Amanda Victoria Gomes, Torrecilhas, Ana Claudia, Bressan, Rodrigo, Manfro, Gisele Gus, Miguel, Euripedes Constantino, Rohde, Luis Augusto, Pan, Pedro Mario, Salum, Giovanni Abrahão, Pellegrino, Renata, Belangero, Sintia, and Santoro, Marcos Leite
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- 2023
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5. Comparing mental health semi-structured diagnostic interviews and symptom checklists to predict poor life outcomes: an 8-year cohort study from childhood to young adulthood in Brazil
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Hoffmann, Mauricio Scopel, Pine, Daniel S, Georgiades, Katholiki, Szatmari, Peter, Miguel, Euripedes Constantino, Pan, Pedro Mario, Gadelha, Ary, Rohde, Luis Augusto, Merikangas, Kathleen Ries, Milham, Michael Peter, Satterthwaite, Theodore Daniel, and Salum, Giovanni Abrahão
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- 2024
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6. Mental health care delivery and quality of service provision in Brazil
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Marchionatti, Lauro Estivalete, Rocha, Kátia Bones, Becker, Natalia, Gosmann, Natan Pereira, and Salum, Giovanni A.
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- 2023
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7. Measuring strengths and weaknesses in dimensional psychiatry
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Alexander, Lindsay M, Salum, Giovanni A, Swanson, James M, and Milham, Michael P
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Biomedical and Clinical Sciences ,Clinical Sciences ,Psychology ,Brain Disorders ,Behavioral and Social Science ,Mental Health ,Depression ,Mental health ,Adolescent ,Child ,Female ,Humans ,Male ,Mental Disorders ,Psychiatric Status Rating Scales ,Psychiatry ,Psychometrics ,Questionnaires ,rating scales ,methodology ,Cognitive Sciences ,Developmental & Child Psychology ,Clinical sciences ,Applied and developmental psychology ,Clinical and health psychology - Abstract
BackgroundThe Extended Strengths and Weaknesses Assessment of Normal Behavior (E-SWAN) reconceptualizes each diagnostic criterion for selected DSM-5 disorders as a behavior, which can range from high (strengths) to low (weaknesses). Initial development focused on Panic Disorder, Social Anxiety, Major Depression, and Disruptive Mood Dysregulation Disorder.MethodsData were collected from 523 participants (ages 6-17). Parents completed each of the four E-SWAN scales and traditional unidirectional scales addressing the same disorders. Distributional properties, Item Response Theory Analysis (IRT), and Receiver Operating Characteristic (ROC) curves were used to assess and compare the performance of E-SWAN and traditional scales.ResultsIn contrast to the traditional scales, which exhibited truncated distributions, all four E-SWAN scales had symmetric distributions. IRT analyses indicate the E-SWAN subscales provided reliable information about respondents throughout the population distribution; traditional scales only provided reliable information about respondents at the high end of the distribution. Predictive value for DSM-5 diagnoses was comparable to prior scales.ConclusionsE-SWAN bidirectional scales can capture the full spectrum of the population distribution of behavior underlying DSM disorders. The additional information provided can better inform examination of inter-individual variation in population studies, as well as facilitate the identification of factors related to resiliency in clinical samples.
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- 2020
8. Childhood individual and family modifiable risk factors for criminal conviction: a 7-year cohort study from Brazil
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Ziebold, Carolina, Evans-Lacko, Sara, Andrade, Mário César Rezende, Hoffmann, Maurício Scopel, Fonseca, Lais, Barbosa, Matheus Ghossain, Pan, Pedro Mario, Miguel, Euripedes, Bressan, Rodrigo Affonseca, Rohde, Luis Augusto, Salum, Giovanni Abrahão, de Jesus Mari, Jair, and Gadelha, Ary
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- 2022
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9. Childhood Anxiety Symptoms as a Predictor of Psychotic Experiences in Adolescence in a High-Risk Cohort for Psychiatric Disorders
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Machado, Viviane, primary, Fonseca, Lais, additional, Barbosa, Matheus Ghossain, additional, Bressan, Rodrigo A, additional, Pan, Pedro, additional, Rohde, Luis Augusto, additional, Miguel, Euripedes Constantino, additional, Salum, Giovanni A, additional, Ziebold, Carolina, additional, and Gadelha, Ary, additional
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- 2024
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10. Is waiting for rewards good for you? No association between impulsive choice, psychopathology, and functional outcomes in a large cohort sample
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Bado, Patricia P., primary, Salum, Giovanni A., additional, Rohde, Luis A., additional, Gadelha, Ary, additional, Pan, Pedro M., additional, Miguel, Eurípedes C., additional, Tripp, Gail, additional, and Furukawa, Emi, additional
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- 2024
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11. Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
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Brauer, M, Roth, G, Aravkin, A, Zheng, P, Abate, K, Abate, Y, Abbafati, C, Abbasgholizadeh, R, Abbasi, M, Abbasian, M, Abbasifard, M, Abbasi-Kangevari, M, Abd ElHafeez, S, Abd-Elsalam, S, Abdi, P, Abdollahi, M, Abdoun, M, Abdulah, D, Abdullahi, A, Abebe, M, Abedi, A, Abegaz, T, Abeldaño Zuñiga, R, Abiodun, O, Abiso, T, Aboagye, R, Abolhassani, H, Abouzid, M, Aboye, G, Abreu, L, Abualruz, H, Abubakar, B, Abu-Gharbieh, E, Abukhadijah, H, Aburuz, S, Abu-Zaid, A, Adane, M, Addo, I, Addolorato, G, Adedoyin, R, Adekanmbi, V, Aden, B, Adetunji, J, Adeyeoluwa, T, Adha, R, Adibi, A, Adnani, Q, Adzigbli, L, Afolabi, A, Afolabi, R, Afshin, A, Afyouni, S, Afzal, M, Afzal, S, Agampodi, S, Agbozo, F, Aghamiri, S, Agodi, A, Agrawal, A, Agyemang-Duah, W, Ahinkorah, B, Ahmad, A, Ahmad, D, Ahmad, F, Ahmad, N, Ahmad, S, Ahmad, T, Ahmed, A, Ahmed, L, Ahmed, M, Ahmed, S, Ajami, M, Akalu, G, Akara, E, Akbarialiabad, H, Akhlaghi, S, Akinosoglou, K, Akinyemiju, T, Akkaif, M, Akkala, S, Akombi-Inyang, B, Al Awaidy, S, Al Hasan, S, Alahdab, F, AL-Ahdal, T, Alalalmeh, S, Alalwan, T, Al-Aly, Z, Alam, K, Alam, N, Alanezi, F, Alanzi, T, Albakri, A, Albataineh, M, Aldhaleei, W, Aldridge, R, Alemayohu, M, Alemu, Y, Al-Fatly, B, Al-Gheethi, A, Al-Habbal, K, Alhabib, K, Alhassan, R, Ali, A, Ali, B, Ali, I, Ali, L, Ali, M, Ali, R, Ali, S, Ali, W, Alicandro, G, Alif, S, Aljunid, S, Alla, F, Al-Marwani, S, Al-Mekhlafi, H, Almustanyir, S, Alomari, M, Alonso, J, Alqahtani, J, Alqutaibi, A, Al-Raddadi, R, Alrawashdeh, A, Al-Rifai, R, Alrousan, S, Al-Sabah, S, Alshahrani, N, Altaany, Z, Altaf, A, Al-Tawfiq, J, Altirkawi, K, Aluh, D, Alvis-Guzman, N, Alvis-Zakzuk, N, Alwafi, H, Al-Wardat, M, Al-Worafi, Y, Aly, H, Aly, S, Alzoubi, K, Al-Zyoud, W, Amaechi, U, Aman Mohammadi, M, Amani, R, Amiri, S, Amirzade-Iranaq, M, Ammirati, E, Amu, H, Amugsi, D, Amusa, G, Ancuceanu, R, Anderlini, D, Anderson, J, Andrade, P, Andrei, C, Andrei, T, Anenberg, S, Angappan, D, Angus, C, Anil, A, Anil, S, Anjum, A, Anoushiravani, A, Antonazzo, I, Antony, C, Antriyandarti, E, Anuoluwa, B, Anvari, D, Anvari, S, Anwar, S, Anwer, R, Anyabolo, E, Anyasodor, A, Apostol, G, Arabloo, J, Arabzadeh Bahri, R, Arafat, M, Areda, D, Aregawi, B, Aremu, A, Armocida, B, Arndt, M, Ärnlöv, J, Arooj, M, Artamonov, A, Artanti, K, Aruleba, I, Arumugam, A, Asbeutah, A, Asgary, S, Asgedom, A, Ashbaugh, C, Ashemo, M, Ashraf, T, Askarinejad, A, Assmus, M, Astell-Burt, T, Athar, M, Athari, S, Atorkey, P, Atreya, A, Aujayeb, A, Ausloos, M, Avila-Burgos, L, Awoke, A, Ayala Quintanilla, B, Ayatollahi, H, Ayestas Portugal, C, Ayuso-Mateos, J, Azadnajafabad, S, Azevedo, R, Azhar, G, Azizi, H, Azzam, A, Backhaus, I, Badar, M, Badiye, A, Bagga, A, Baghdadi, S, Bagheri, N, Bagherieh, S, Bahrami Taghanaki, P, Bai, R, Baig, A, Baker, J, Bakkannavar, S, Balasubramanian, M, Baltatu, O, Bam, K, Bandyopadhyay, S, Banik, B, Banik, P, Banke-Thomas, A, Bansal, H, Barchitta, M, Bardhan, M, Bardideh, E, Barker-Collo, S, Bärnighausen, T, Barone-Adesi, F, Barqawi, H, Barrero, L, Barrow, A, Barteit, S, Basharat, Z, Basiru, A, Basso, J, Bastan, M, Basu, S, Batchu, S, Batra, K, Batra, R, Baune, B, Bayati, M, Bayileyegn, N, Beaney, T, Behnoush, A, Beiranvand, M, Béjot, Y, Bekele, A, Belgaumi, U, Bell, A, Bell, M, Bello, M, Bello, O, Belo, L, Beloukas, A, Bendak, S, Bennett, D, Bennitt, F, Bensenor, I, Benzian, H, Beran, A, Berezvai, Z, Bernabe, E, Bernstein, R, Bettencourt, P, Bhagavathula, A, Bhala, N, Bhandari, D, Bhardwaj, N, Bhardwaj, P, Bhaskar, S, Bhat, A, Bhat, V, Bhatti, G, Bhatti, J, Bhatti, M, Bhatti, R, Bhuiyan, M, Bhutta, Z, Bikbov, B, Bishai, J, Bisignano, C, Biswas, A, Biswas, B, Biswas, R, Bjørge, T, Boachie, M, Boakye, H, Bockarie, M, Bodolica, V, Bodunrin, A, Bogale, E, Bolla, S, Boloor, A, Bonakdar Hashemi, M, Boppana, S, Bora Basara, B, Borhany, H, Botero Carvajal, A, Bouaoud, S, Boufous, S, Bourne, R, Boxe, C, Braithwaite, D, Brant, L, Brar, A, Breitborde, N, Breitner, S, Brenner, H, Briko, A, Britton, G, Brown, C, Browne, A, Brunoni, A, Bryazka, D, Bulamu, N, Bulto, L, Buonsenso, D, Burkart, K, Burns, R, Busse, R, Bustanji, Y, Butt, N, Butt, Z, Caetano dos Santos, F, Cagney, J, Cahuana-Hurtado, L, Calina, D, Cámera, L, Campos, L, Campos-Nonato, I, Cao, C, Cao, F, Cao, Y, Capodici, A, Cárdenas, R, Carr, S, Carreras, G, Carrero, J, Carugno, A, Carvalho, F, Carvalho, M, Castaldelli-Maia, J, Castañeda-Orjuela, C, Castelpietra, G, Catalá-López, F, Catapano, A, Cattaruzza, M, Caye, A, Cederroth, C, Cegolon, L, Cenderadewi, M, Cercy, K, Cerin, E, Chadwick, J, Chakraborty, C, Chakraborty, P, Chakraborty, S, Chan, J, Chan, R, Chandan, J, Chandika, R, Chaturvedi, P, Chen, A, Chen, C, Chen, H, Chen, M, Chen, S, Cheng, C, Cheng, E, Cherbuin, N, Chi, G, Chichagi, F, Chimed-Ochir, O, Chimoriya, R, Ching, P, Chirinos-Caceres, J, Chitheer, A, Cho, W, Chong, B, Chopra, H, Chowdhury, R, Christopher, D, Chu, D, Chukwu, I, Chung, E, Chung, S, Chutiyami, M, Cioffi, I, Cogen, R, Cohen, A, Columbus, A, Conde, J, Corlateanu, A, Cortese, S, Cortesi, P, Costa, V, Costanzo, S, Criqui, M, Cruz, J, Cruz-Martins, N, Culbreth, G, da Silva, A, Dadras, O, Dai, X, Dai, Z, Daikwo, P, Dalli, L, Damiani, G, D'Amico, E, D'Anna, L, Darwesh, A, Das, J, Das, S, Dash, N, Dashti, M, Dávila-Cervantes, C, Davis Weaver, N, Davitoiu, D, De la Hoz, F, de la Torre-Luque, A, De Leo, D, Debopadhaya, S, Degenhardt, L, Del Bo', C, Delgado-Enciso, I, Delgado-Saborit, J, Demoze, C, Denova-Gutiérrez, E, Dervenis, N, Dervišević, E, Desai, H, Desai, R, Devanbu, V, Dewan, S, Dhali, A, Dhama, K, Dhane, A, Dhimal, M, Dhingra, S, Dhulipala, V, Dhungana, R, Dias da Silva, D, Diaz, D, Diaz, L, Diaz, M, Dima, A, Ding, D, Dinu, M, Djalalinia, S, Do, T, do Prado, C, Dodangeh, M, Dohare, S, Dokova, K, Dong, W, Dongarwar, D, D'Oria, M, Dorostkar, F, Dorsey, E, Doshi, R, Doshmangir, L, Dowou, R, Driscoll, T, Dsouza, A, Dsouza, H, Dumith, S, Duncan, B, Duraes, A, Duraisamy, S, Dushpanova, A, Dzianach, P, Dziedzic, A, Ebrahimi, A, Echieh, C, Ed-Dra, A, Edinur, H, Edvardsson, D, Edvardsson, K, Efendi, F, Eftekharimehrabad, A, Eini, E, Ekholuenetale, M, Ekundayo, T, El Arab, R, El Sayed Zaki, M, El-Dahiyat, F, Elemam, N, Elgar, F, Elgohary, G, Elhabashy, H, Elhadi, M, Elmehrath, A, Elmeligy, O, Elshaer, M, Elsohaby, I, Emeto, T, Esfandiari, N, Eshrati, B, Eslami, M, Esmaeili, S, Estep, K, Etaee, F, Fabin, N, Fagbamigbe, A, Fagbule, O, Fahimi, S, Falzone, L, Fareed, M, Farinha, C, Faris, M, Faris, P, Faro, A, Fasina, F, Fatehizadeh, A, Fauk, N, Fazylov, T, Feigin, V, Feng, X, Fereshtehnejad, S, Feroze, A, Ferrara, P, Ferrari, A, Ferreira, N, Fetensa, G, Feyisa, B, Filip, I, Fischer, F, Fitriana, I, Flavel, J, Flohr, C, Flood, D, Flor, L, Foigt, N, Folayan, M, Force, L, Fortuna, D, Foschi, M, Franklin, R, Freitas, A, Friedman, S, Fux, B, G, S, Gaal, P, Gaihre, S, Gajdács, M, Galali, Y, Gallus, S, Gandhi, A, Ganesan, B, Ganiyani, M, Garcia, V, Gardner, W, Garg, R, Gautam, R, Gebi, T, Gebregergis, M, Gebrehiwot, M, Gebremariam, T, Gebremeskel, T, Gerema, U, Getacher, L, Getahun, G, Getie, M, Ghadirian, F, Ghafarian, S, Ghaffari Jolfayi, A, Ghailan, K, Ghajar, A, Ghasemi, M, Ghasempour Dabaghi, G, Ghasemzadeh, A, Ghassemi, F, Ghazy, R, Gholami, A, Gholamrezanezhad, A, Gholizadeh, N, Ghorbani, M, Gil, A, Gil, G, Gilbertson, N, Gill, P, Gill, T, Gindaba, E, Girmay, A, Glasbey, J, Gnedovskaya, E, Göbölös, L, Godinho, M, Goel, A, Golechha, M, Goleij, P, Golinelli, D, Gomes, N, Gopalani, S, Gorini, G, Goudarzi, H, Goulart, A, Gouravani, M, Goyal, A, Graham, S, Grivna, M, Grosso, G, Guan, S, Guarducci, G, Gubari, M, Guha, A, Guicciardi, S, Gulati, S, Gulisashvili, D, Gunawardane, D, Guo, C, Gupta, A, Gupta, B, Gupta, M, Gupta, R, Gupta, S, Gupta, V, Habibzadeh, F, Habibzadeh, P, Hadaro, T, Hadian, Z, Haep, N, Haghi-Aminjan, H, Haghmorad, D, Hagins, H, Haile, D, Hailu, A, Hajj Ali, A, Halboub, E, Halimi, A, Hall, B, Haller, S, Halwani, R, Hamadeh, R, Hamdy, N, Hameed, S, Hamidi, S, Hammoud, A, Hanif, A, Hanifi, N, Haq, Z, Haque, M, Harapan, H, Hargono, A, Haro, J, Hasaballah, A, Hasan, I, Hasan, M, Hasan, S, Hasani, H, Hasanian, M, Hashmeh, N, Hasnain, M, Hassan, A, Hassan, I, Hassan Zadeh Tabatabaei, M, Hassani, S, Hassanipour, S, Hassankhani, H, Haubold, J, Havmoeller, R, Hay, S, Hebert, J, Hegazi, O, Hegena, T, Heidari, G, Heidari, M, Helfer, B, Hemmati, M, Henson, C, Herbert, M, Herteliu, C, Heuer, A, Hezam, K, Hinneh, T, Hiraike, Y, Hoan, N, Holla, R, Hon, J, Hoque, M, Horita, N, Hossain, S, Hosseini, S, Hosseinzadeh, H, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Hoven, H, Hsairi, M, Hsu, J, Hu, C, Huang, J, Huda, M, Hulland, E, Hultström, M, Hushmandi, K, Hussain, J, Hussein, N, Huynh, C, Huynh, H, Ibitoye, S, Idowu, O, Ihler, A, Ikeda, N, Ikuta, K, Ilesanmi, O, Ilic, I, Ilic, M, Imam, M, Immurana, M, Inbaraj, L, Irham, L, Isa, M, Islam, M, Ismail, F, Ismail, N, Iso, H, Isola, G, Iwagami, M, Iwu, C, Iwu-Jaja, C, J, V, Jaafari, J, Jacob, L, Jacobsen, K, Jadidi-Niaragh, F, Jahankhani, K, Jahanmehr, N, Jahrami, H, Jain, A, Jain, N, Jairoun, A, Jaiswal, A, Jakovljevic, M, Jalilzadeh Yengejeh, R, Jamora, R, Jatau, A, Javadov, S, Javaheri, T, Jayaram, S, Jeganathan, J, Jeswani, B, Jiang, H, Johnson, C, Jokar, M, Jomehzadeh, N, Jonas, J, Joo, T, Joseph, A, Joseph, N, Joshi, V, Joshua, C, Jozwiak, J, Jürisson, M, Kaambwa, B, Kabir, A, Kabir, Z, Kadashetti, V, Kahn, E, Kalani, R, Kaliyadan, F, Kalra, S, Kamath, R, Kanagasabai, T, Kanchan, T, Kandel, H, Kanmiki, E, Kanmodi, K, Kansal, S, Kapner, D, Kapoor, N, Karagiannidis, E, Karajizadeh, M, Karakasis, P, Karanth, S, Karaye, I, Karch, A, Karim, A, Karimi, H, Karmakar, S, Kashoo, F, Kasraei, H, Kassahun, W, Kassebaum, N, Kassel, M, Katikireddi, S, Kauppila, J, Kawakami, N, Kaydi, N, Kayode, G, Kazemi, F, Keiyoro, P, Kemmer, L, Kempen, J, Kerr, J, Kesse-Guyot, E, Khader, Y, Khafaie, M, Khajuria, H, Khalaji, A, Khalil, M, Khalilian, A, Khamesipour, F, Khan, A, Khan, M, Khanmohammadi, S, Khatab, K, Khatatbeh, H, Khatatbeh, M, Khatib, M, Khavandegar, A, Khayat Kashani, H, Khidri, F, Khodadoust, E, Khormali, M, Khorrami, Z, Khosla, A, Khosrowjerdi, M, Khreis, H, Khusun, H, Kifle, Z, Kim, K, Kim, M, Kim, Y, Kimokoti, R, Kisa, A, Kisa, S, Knibbs, L, Knudsen, A, Koh, D, Kolahi, A, Kompani, F, Kong, J, Koren, G, Korja, M, Korshunov, V, Korzh, O, Kosen, S, Kothari, N, Koul, P, Koulmane Laxminarayana, S, Krishan, K, Krishnamoorthy, V, Krishnamoorthy, Y, Krishnan, B, Krohn, K, Kuate Defo, B, Kucuk Bicer, B, Kuddus, M, Kugbey, N, Kuitunen, I, Kulimbet, M, Kulkarni, V, Kumar, A, Kumar, N, Kumar, V, Kundu, S, Kurmi, O, Kusnali, A, Kusuma, D, Kutluk, T, La Vecchia, C, Ladan, M, Laflamme, L, Lahariya, C, Lai, D, Lal, D, Lallukka, T, Lám, J, Lan, Q, Lan, T, Landires, I, Lanfranchi, F, Langguth, B, Lansingh, V, Laplante-Lévesque, A, Larijani, B, Larsson, A, Lasrado, S, Lauriola, P, Le, H, Le, L, Le, N, Le, T, Leasher, J, Ledda, C, Lee, M, Lee, P, Lee, S, Lee, Y, Legrand, K, Leigh, J, Leong, E, Lerango, T, 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Singh, Narinder Pal, Singh, Paramdeep, Singh, Surjit, Sinto, Robert, Sivakumar, Shravan, Siwal, Samarjeet Singh, Skhvitaridze, Natia, Skou, Søren T, Sleet, David A, Sobia, Farrukh, Soboka, Matiwos, Socea, Bogdan, Solaimanian, Shahabaddin, Solanki, Ranjan, Solanki, Shipra, Soliman, Sameh S M, Somayaji, Ranjani, Song, Yi, Sorensen, Reed J D, Soriano, Joan B, Soyiri, Ireneous N, Spartalis, Michael, Spearman, Sandra, Spencer, Cory N, Sreeramareddy, Chandrashekhar T, Stachteas, Panagiotis, Stafford, Lauryn K, Stanaway, Jeffrey D, Stanikzai, Muhammad Haroon, Stein, Caroline, Stein, Dan J, Steinbeis, Fridolin, Steiner, Caitlyn, Steinke, Sabine, Steiropoulos, Paschalis, Stockfelt, Leo, Stokes, Mark A, Straif, Kurt, Stranges, Saverio, Subedi, Narayan, Subramaniyan, Vetriselvan, Suleman, Muhammad, Suliankatchi Abdulkader, Rizwan, Sundström, Johan, Sunkersing, David, Sunnerhagen, Katharina S, Suresh, Vinay, Swain, Chandan Kumar, Szarpak, Lukasz, Szeto, Mindy D, Tabaee Damavandi, Payam, Tabarés-Seisdedos, Rafael, Tabatabaei, Seyyed Mohammad, Tabatabaei Malazy, Ozra, Tabatabaeizadeh, Seyed-Amir, Tabatabai, Shima, Tabche, Celine, Tabish, Mohammad, Tadakamadla, Santosh Kumar, Taheri Abkenar, Yasaman, Taheri Soodejani, Moslem, Taherkhani, Amir, Taiba, Jabeen, Takahashi, Ken, Talaat, Iman M, Tamuzi, Jacques Lukenze, Tan, Ker-Kan, Tang, Haosu, Tat, Nathan Y, Taveira, Nuno, Tefera, Yibekal Manaye, Tehrani-Banihashemi, Arash, Temesgen, Worku Animaw, Temsah, Mohamad-Hani, Teramoto, Masayuki, Terefa, Dufera Rikitu, Teye-Kwadjo, Enoch, Thakur, Ramna, Thangaraju, Pugazhenthan, Thankappan, Kavumpurathu Raman, Thapar, Rekha, Thayakaran, Rasiah, Thirunavukkarasu, Sathish, Thomas, Nihal, Thomas, Nikhil Kenny, Tian, Jing, Tichopad, Ales, Ticoalu, Jansje Henny Vera, Tiruye, Tenaw Yimer, Tobe-Gai, Ruoyan, Tolani, Musliu Adetola, Tolossa, Tadesse, Tonelli, Marcello, Topor-Madry, Roman, Topouzis, Fotis, Touvier, Mathilde, Tovani-Palone, Marcos Roberto, Trabelsi, Khaled, Tran, Jasmine T, Tran, Mai Thi Ngoc, Tran, Nghia Minh, Trico, Domenico, Trihandini, Indang, Troeger, Christopher E, Tromans, Samuel Joseph, Truyen, Thien Tan Tri Tai, Tsatsakis, Aristidis, Tsermpini, Evangelia Eirini, Tumurkhuu, Munkhtuya, Udoakang, Aniefiok John, Udoh, Arit, Ullah, Atta, Ullah, Saeed, Ullah, Sana, Umair, Muhammad, Umakanthan, Srikanth, Unim, Brigid, Unnikrishnan, Bhaskaran, Upadhyay, Era, Urso, Daniele, Usman, Jibrin Sammani, Vaithinathan, Asokan Govindaraj, Vakili, Omid, Valenti, Mario, Valizadeh, Rohollah, Van den Eynde, Jef, van Donkelaar, Aaron, Varga, Orsolya, Vart, Priya, Varthya, Shoban Babu, Vasankari, Tommi Juhani, Vasic, Milena, Vaziri, Siavash, Venketasubramanian, Narayanaswamy, Verghese, Nicholas Alexander, Verma, Madhur, Veroux, Massimiliano, Verras, Georgios-Ioannis, Vervoort, Dominique, Villafañe, Jorge Hugo, Villalobos-Daniel, Victor E, Villani, Leonardo, Villanueva, Gabriela Ines, Vinayak, Manish, Violante, Francesco S, Vlassov, Vasily, Vo, Bay, Vollset, Stein Emil, Volovat, Simona Ruxandra, Vos, Theo, Vujcic, Isidora S, Waheed, Yasir, Wang, Cong, Wang, Fang, Wang, Shu, Wang, Yanzhong, Wang, Yuan-Pang, Wanjau, Mary Njeri, Waqas, Muhammad, Ward, Paul, Waris, Abdul, Wassie, Emebet Gashaw, Weerakoon, Kosala Gayan, Weintraub, Robert G, Weiss, Daniel J, Weiss, Eli J, Weldetinsaa, Haftom Legese Legese, Wells, Katherine M, Wen, Yi Feng, Wiangkham, Taweewat, Wickramasinghe, Nuwan Darshana, Wilkerson, Caroline, Willeit, Peter, Wilson, Shadrach, Wong, Yen Jun, Wongsin, Utoomporn, Wozniak, Sarah, Wu, Chenkai, Wu, Dongze, Wu, Felicia, Wu, Zenghong, Xia, Juan, Xiao, Hong, Xu, Suowen, Xu, Xiaoyue, Xu, Yvonne Yiru, Yadav, Mukesh Kumar, Yaghoubi, Sajad, Yamagishi, Kazumasa, Yang, Lin, Yano, Yuichiro, Yaribeygi, Habib, Yasufuku, Yuichi, Ye, Pengpeng, Yesodharan, Renjulal, Yesuf, Subah Abderehim, Yezli, Saber, Yi, Siyan, Yiğit, Arzu, Yigzaw, Zeamanuel Anteneh, Yin, Dehui, Yip, Paul, Yismaw, Malede Berihun, Yon, Dong Keon, Yonemoto, Naohiro, You, Yuyi, Younis, Mustafa Z, Yousefi, Zabihollah, Yu, Chuanhua, Yu, Yong, Zadey, Siddhesh, Zadnik, Vesna, Zakham, Fathiah, Zaki, Nazar, Zakzuk, Josefina, Zamagni, Giulia, Zaman, Sojib Bin, Zandieh, Ghazal G Z, Zanghì, Aurora, Zar, Heather J, Zare, Iman, Zarimeidani, Fatemeh, Zastrozhin, Mikhail Sergeevich, Zeng, Youjie, Zhai, Chunxia, Zhang, Anthony Lin, Zhang, Haijun, Zhang, Liqun, Zhang, Meixin, Zhang, Yunquan, Zhang, Zhenyu, Zhang, Zhi-Jiang, Zhao, Hanqing, Zhao, Jeff T, Zhao, Xiu-Ju George, Zhao, Yang, Zhao, Yong, Zhong, Chenwen, Zhou, Jingjing, Zhou, Juexiao, Zhou, Shangcheng, Zhu, Bin, Zhu, Lei, Zhu, Zhaohua, Ziaeian, Boback, Ziafati, Makan, Zielińska, Magdalena, Zimsen, Stephanie R M, Zoghi, Ghazal, Zoller, Thomas, Zumla, Alimuddin, Zyoud, Sa'ed H, Zyoud, Samer H, Murray, Christopher J L, and Gakidou, Emmanuela
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- 2024
12. Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder
- Author
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Nievergelt, Caroline M., Maihofer, Adam X., Atkinson, Elizabeth G., Chen, Chia Yen, Choi, Karmel W., Coleman, Jonathan R.I., Daskalakis, Nikolaos P., Duncan, Laramie E., Polimanti, Renato, Aaronson, Cindy, Amstadter, Ananda B., Andersen, Soren B., Andreassen, Ole A., Arbisi, Paul A., Ashley-Koch, Allison E., Austin, S. Bryn, Avdibegoviç, Esmina, Babić, Dragan, Bacanu, Silviu Alin, Baker, Dewleen G., Batzler, Anthony, Beckham, Jean C., Belangero, Sintia, Benjet, Corina, Bergner, Carisa, Bierer, Linda M., Biernacka, Joanna M., Bierut, Laura J., Bisson, Jonathan I., Boks, Marco P., Bolger, Elizabeth A., Brandolino, Amber, Breen, Gerome, Bressan, Rodrigo Affonseca, Bryant, Richard A., Bustamante, Angela C., Bybjerg-Grauholm, Jonas, Bækvad-Hansen, Marie, Børglum, Anders D., Børte, Sigrid, Cahn, Leah, Calabrese, Joseph R., Caldas-de-Almeida, Jose Miguel, Chatzinakos, Chris, Cheema, Sheraz, Clouston, Sean A.P., Colodro-Conde, Lucía, Coombes, Brandon J., Cruz-Fuentes, Carlos S., Dale, Anders M., Dalvie, Shareefa, Davis, Lea K., Deckert, Jürgen, Delahanty, Douglas L., Dennis, Michelle F., Desarnaud, Frank, DiPietro, Christopher P., Disner, Seth G., Docherty, Anna R., Domschke, Katharina, Dyb, Grete, Kulenović, Alma Džubur, Edenberg, Howard J., Evans, Alexandra, Fabbri, Chiara, Fani, Negar, Farrer, Lindsay A., Feder, Adriana, Feeny, Norah C., Flory, Janine D., Forbes, David, Franz, Carol E., Galea, Sandro, Garrett, Melanie E., Gelaye, Bizu, Gelernter, Joel, Geuze, Elbert, Gillespie, Charles F., Goleva, Slavina B., Gordon, Scott D., Goçi, Aferdita, Grasser, Lana Ruvolo, Guindalini, Camila, Haas, Magali, Hagenaars, Saskia, Hauser, Michael A., Heath, Andrew C., Hemmings, Sian M.J., Hesselbrock, Victor, Hickie, Ian B., Hogan, Kelleigh, Hougaard, David Michael, Huang, Hailiang, Huckins, Laura M., Hveem, Kristian, Jakovljević, Miro, Javanbakht, Arash, Jenkins, Gregory D., Johnson, Jessica, Jones, Ian, Jovanovic, Tanja, Karstoft, Karen Inge, Kaufman, Milissa L., Kennedy, James L., Kessler, Ronald C., Khan, Alaptagin, Kimbrel, Nathan A., King, Anthony P., Koen, Nastassja, Kotov, Roman, Kranzler, Henry R., Krebs, Kristi, Kremen, William S., Kuan, Pei Fen, Lawford, Bruce R., Lebois, Lauren A.M., Lehto, Kelli, Levey, Daniel F., Lewis, Catrin, Liberzon, Israel, Linnstaedt, Sarah D., Logue, Mark W., Lori, Adriana, Lu, Yi, Luft, Benjamin J., Lupton, Michelle K., Luykx, Jurjen J., Makotkine, Iouri, Maples-Keller, Jessica L., Marchese, Shelby, Marmar, Charles, Martin, Nicholas G., Martínez-Levy, Gabriela A., McAloney, Kerrie, McFarlane, Alexander, McLaughlin, Katie A., McLean, Samuel A., Medland, Sarah E., Mehta, Divya, Meyers, Jacquelyn, Michopoulos, Vasiliki, Mikita, Elizabeth A., Milani, Lili, Milberg, William, Miller, Mark W., Morey, Rajendra A., Morris, Charles Phillip, Mors, Ole, Mortensen, Preben Bo, Mufford, Mary S., Nelson, Elliot C., Nordentoft, Merete, Norman, Sonya B., Nugent, Nicole R., O’Donnell, Meaghan, Orcutt, Holly K., Pan, Pedro M., Panizzon, Matthew S., Pathak, Gita A., Peters, Edward S., Peterson, Alan L., Peverill, Matthew, Pietrzak, Robert H., Polusny, Melissa A., Porjesz, Bernice, Powers, Abigail, Qin, Xue Jun, Ratanatharathorn, Andrew, Risbrough, Victoria B., Roberts, Andrea L., Rothbaum, Alex O., Rothbaum, Barbara O., Roy-Byrne, Peter, Ruggiero, Kenneth J., Rung, Ariane, Runz, Heiko, Rutten, Bart P.F., de Viteri, Stacey Saenz, Salum, Giovanni Abrahão, Sampson, Laura, Sanchez, Sixto E., Santoro, Marcos, Seah, Carina, Seedat, Soraya, Seng, Julia S., Shabalin, Andrey, Sheerin, Christina M., Silove, Derrick, Smith, Alicia K., Smoller, Jordan W., Sponheim, Scott R., Stein, Dan J., Stensland, Synne, Stevens, Jennifer S., Sumner, Jennifer A., Teicher, Martin H., Thompson, Wesley K., Tiwari, Arun K., Trapido, Edward, Uddin, Monica, Ursano, Robert J., Valdimarsdóttir, Unnur, Van Hooff, Miranda, Vermetten, Eric, Vinkers, Christiaan H., Voisey, Joanne, Wang, Yunpeng, Wang, Zhewu, Waszczuk, Monika, Weber, Heike, Wendt, Frank R., Werge, Thomas, Williams, Michelle A., Williamson, Douglas E., Winsvold, Bendik S., Winternitz, Sherry, Wolf, Christiane, Wolf, Erika J., Xia, Yan, Xiong, Ying, Yehuda, Rachel, Young, Keith A., Young, Ross Mc D., Zai, Clement C., Zai, Gwyneth C., Zervas, Mark, Zhao, Hongyu, Zoellner, Lori A., Zwart, John Anker, deRoon-Cassini, Terri, van Rooij, Sanne J.H., van den Heuvel, Leigh L., Stein, Murray B., Ressler, Kerry J., Koenen, Karestan C., Nievergelt, Caroline M., Maihofer, Adam X., Atkinson, Elizabeth G., Chen, Chia Yen, Choi, Karmel W., Coleman, Jonathan R.I., Daskalakis, Nikolaos P., Duncan, Laramie E., Polimanti, Renato, Aaronson, Cindy, Amstadter, Ananda B., Andersen, Soren B., Andreassen, Ole A., Arbisi, Paul A., Ashley-Koch, Allison E., Austin, S. Bryn, Avdibegoviç, Esmina, Babić, Dragan, Bacanu, Silviu Alin, Baker, Dewleen G., Batzler, Anthony, Beckham, Jean C., Belangero, Sintia, Benjet, Corina, Bergner, Carisa, Bierer, Linda M., Biernacka, Joanna M., Bierut, Laura J., Bisson, Jonathan I., Boks, Marco P., Bolger, Elizabeth A., Brandolino, Amber, Breen, Gerome, Bressan, Rodrigo Affonseca, Bryant, Richard A., Bustamante, Angela C., Bybjerg-Grauholm, Jonas, Bækvad-Hansen, Marie, Børglum, Anders D., Børte, Sigrid, Cahn, Leah, Calabrese, Joseph R., Caldas-de-Almeida, Jose Miguel, Chatzinakos, Chris, Cheema, Sheraz, Clouston, Sean A.P., Colodro-Conde, Lucía, Coombes, Brandon J., Cruz-Fuentes, Carlos S., Dale, Anders M., Dalvie, Shareefa, Davis, Lea K., Deckert, Jürgen, Delahanty, Douglas L., Dennis, Michelle F., Desarnaud, Frank, DiPietro, Christopher P., Disner, Seth G., Docherty, Anna R., Domschke, Katharina, Dyb, Grete, Kulenović, Alma Džubur, Edenberg, Howard J., Evans, Alexandra, Fabbri, Chiara, Fani, Negar, Farrer, Lindsay A., Feder, Adriana, Feeny, Norah C., Flory, Janine D., Forbes, David, Franz, Carol E., Galea, Sandro, Garrett, Melanie E., Gelaye, Bizu, Gelernter, Joel, Geuze, Elbert, Gillespie, Charles F., Goleva, Slavina B., Gordon, Scott D., Goçi, Aferdita, Grasser, Lana Ruvolo, Guindalini, Camila, Haas, Magali, Hagenaars, Saskia, Hauser, Michael A., Heath, Andrew C., Hemmings, Sian M.J., Hesselbrock, Victor, Hickie, Ian B., Hogan, Kelleigh, Hougaard, David Michael, Huang, Hailiang, Huckins, Laura M., Hveem, Kristian, Jakovljević, Miro, Javanbakht, Arash, Jenkins, Gregory D., Johnson, Jessica, Jones, Ian, Jovanovic, Tanja, Karstoft, Karen Inge, Kaufman, Milissa L., Kennedy, James L., Kessler, Ronald C., Khan, Alaptagin, Kimbrel, Nathan A., King, Anthony P., Koen, Nastassja, Kotov, Roman, Kranzler, Henry R., Krebs, Kristi, Kremen, William S., Kuan, Pei Fen, Lawford, Bruce R., Lebois, Lauren A.M., Lehto, Kelli, Levey, Daniel F., Lewis, Catrin, Liberzon, Israel, Linnstaedt, Sarah D., Logue, Mark W., Lori, Adriana, Lu, Yi, Luft, Benjamin J., Lupton, Michelle K., Luykx, Jurjen J., Makotkine, Iouri, Maples-Keller, Jessica L., Marchese, Shelby, Marmar, Charles, Martin, Nicholas G., Martínez-Levy, Gabriela A., McAloney, Kerrie, McFarlane, Alexander, McLaughlin, Katie A., McLean, Samuel A., Medland, Sarah E., Mehta, Divya, Meyers, Jacquelyn, Michopoulos, Vasiliki, Mikita, Elizabeth A., Milani, Lili, Milberg, William, Miller, Mark W., Morey, Rajendra A., Morris, Charles Phillip, Mors, Ole, Mortensen, Preben Bo, Mufford, Mary S., Nelson, Elliot C., Nordentoft, Merete, Norman, Sonya B., Nugent, Nicole R., O’Donnell, Meaghan, Orcutt, Holly K., Pan, Pedro M., Panizzon, Matthew S., Pathak, Gita A., Peters, Edward S., Peterson, Alan L., Peverill, Matthew, Pietrzak, Robert H., Polusny, Melissa A., Porjesz, Bernice, Powers, Abigail, Qin, Xue Jun, Ratanatharathorn, Andrew, Risbrough, Victoria B., Roberts, Andrea L., Rothbaum, Alex O., Rothbaum, Barbara O., Roy-Byrne, Peter, Ruggiero, Kenneth J., Rung, Ariane, Runz, Heiko, Rutten, Bart P.F., de Viteri, Stacey Saenz, Salum, Giovanni Abrahão, Sampson, Laura, Sanchez, Sixto E., Santoro, Marcos, Seah, Carina, Seedat, Soraya, Seng, Julia S., Shabalin, Andrey, Sheerin, Christina M., Silove, Derrick, Smith, Alicia K., Smoller, Jordan W., Sponheim, Scott R., Stein, Dan J., Stensland, Synne, Stevens, Jennifer S., Sumner, Jennifer A., Teicher, Martin H., Thompson, Wesley K., Tiwari, Arun K., Trapido, Edward, Uddin, Monica, Ursano, Robert J., Valdimarsdóttir, Unnur, Van Hooff, Miranda, Vermetten, Eric, Vinkers, Christiaan H., Voisey, Joanne, Wang, Yunpeng, Wang, Zhewu, Waszczuk, Monika, Weber, Heike, Wendt, Frank R., Werge, Thomas, Williams, Michelle A., Williamson, Douglas E., Winsvold, Bendik S., Winternitz, Sherry, Wolf, Christiane, Wolf, Erika J., Xia, Yan, Xiong, Ying, Yehuda, Rachel, Young, Keith A., Young, Ross Mc D., Zai, Clement C., Zai, Gwyneth C., Zervas, Mark, Zhao, Hongyu, Zoellner, Lori A., Zwart, John Anker, deRoon-Cassini, Terri, van Rooij, Sanne J.H., van den Heuvel, Leigh L., Stein, Murray B., Ressler, Kerry J., and Koenen, Karestan C.
- Abstract
Post-traumatic stress disorder (PTSD) genetics are characterized by lower discoverability than most other psychiatric disorders. The contribution to biological understanding from previous genetic studies has thus been limited. We performed a multi-ancestry meta-analysis of genome-wide association studies across 1,222,882 individuals of European ancestry (137,136 cases) and 58,051 admixed individuals with African and Native American ancestry (13,624 cases). We identified 95 genome-wide significant loci (80 new). Convergent multi-omic approaches identified 43 potential causal genes, broadly classified as neurotransmitter and ion channel synaptic modulators (for example, GRIA1, GRM8 and CACNA1E), developmental, axon guidance and transcription factors (for example, FOXP2, EFNA5 and DCC), synaptic structure and function genes (for example, PCLO, NCAM1 and PDE4B) and endocrine or immune regulators (for example, ESR1, TRAF3 and TANK). Additional top genes influence stress, immune, fear and threat-related processes, previously hypothesized to underlie PTSD neurobiology. These findings strengthen our understanding of neurobiological systems relevant to PTSD pathophysiology, while also opening new areas for investigation., Post-traumatic stress disorder (PTSD) genetics are characterized by lower discoverability than most other psychiatric disorders. The contribution to biological understanding from previous genetic studies has thus been limited. We performed a multi-ancestry meta-analysis of genome-wide association studies across 1,222,882 individuals of European ancestry (137,136 cases) and 58,051 admixed individuals with African and Native American ancestry (13,624 cases). We identified 95 genome-wide significant loci (80 new). Convergent multi-omic approaches identified 43 potential causal genes, broadly classified as neurotransmitter and ion channel synaptic modulators (for example, GRIA1, GRM8 and CACNA1E), developmental, axon guidance and transcription factors (for example, FOXP2, EFNA5 and DCC), synaptic structure and function genes (for example, PCLO, NCAM1 and PDE4B) and endocrine or immune regulators (for example, ESR1, TRAF3 and TANK). Additional top genes influence stress, immune, fear and threat-related processes, previously hypothesized to underlie PTSD neurobiology. These findings strengthen our understanding of neurobiological systems relevant to PTSD pathophysiology, while also opening new areas for investigation.
- Published
- 2024
13. Cortical and subcortical brain structure in generalized anxiety disorder: findings from 28 research sites in the ENIGMA-Anxiety Working Group
- Author
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Harrewijn, Anita, Cardinale, Elise M., Groenewold, Nynke A., Bas-Hoogendam, Janna Marie, Aghajani, Moji, Hilbert, Kevin, Cardoner, Narcis, Porta-Casteràs, Daniel, Gosnell, Savannah, Salas, Ramiro, Jackowski, Andrea P., Pan, Pedro M., Salum, Giovanni A., Blair, Karina S., Blair, James R., Hammoud, Mira Z., Milad, Mohammed R., Burkhouse, Katie L., Phan, K. Luan, Schroeder, Heidi K., Strawn, Jeffrey R., Beesdo-Baum, Katja, Jahanshad, Neda, Thomopoulos, Sophia I., Buckner, Randy, Nielsen, Jared A., Smoller, Jordan W., Soares, Jair C., Mwangi, Benson, Wu, Mon-Ju, Zunta-Soares, Giovana B., Assaf, Michal, Diefenbach, Gretchen J., Brambilla, Paolo, Maggioni, Eleonora, Hofmann, David, Straube, Thomas, Andreescu, Carmen, Berta, Rachel, Tamburo, Erica, Price, Rebecca B., Manfro, Gisele G., Agosta, Federica, Canu, Elisa, Cividini, Camilla, Filippi, Massimo, Kostić, Milutin, Munjiza Jovanovic, Ana, Alberton, Bianca A. V., Benson, Brenda, Freitag, Gabrielle F., Filippi, Courtney A., Gold, Andrea L., Leibenluft, Ellen, Ringlein, Grace V., Werwath, Kathryn E., Zwiebel, Hannah, Zugman, André, Grabe, Hans J., Van der Auwera, Sandra, Wittfeld, Katharina, Völzke, Henry, Bülow, Robin, Balderston, Nicholas L., Ernst, Monique, Grillon, Christian, Mujica-Parodi, Lilianne R., van Nieuwenhuizen, Helena, Critchley, Hugo D., Makovac, Elena, Mancini, Matteo, Meeten, Frances, Ottaviani, Cristina, Ball, Tali M., Fonzo, Gregory A., Paulus, Martin P., Stein, Murray B., Gur, Raquel E., Gur, Ruben C., Kaczkurkin, Antonia N., Larsen, Bart, Satterthwaite, Theodore D., Harper, Jennifer, Myers, Michael, Perino, Michael T., Sylvester, Chad M., Yu, Qiongru, Lueken, Ulrike, Veltman, Dick J., Thompson, Paul M., Stein, Dan J., Van der Wee, Nic J. A., Winkler, Anderson M., and Pine, Daniel S.
- Published
- 2021
- Full Text
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14. Telomere length and epigenetic age acceleration in adolescents with anxiety disorders
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Cerveira de Baumont, Angelica, Hoffmann, Mauricio Scopel, Bortoluzzi, Andressa, Fries, Gabriel R., Lavandoski, Patrícia, Grun, Lucas K., Guimarães, Luciano S. P., Guma, Fátima T. C. R., Salum, Giovanni Abrahão, Barbé-Tuana, Florencia M., and Manfro, Gisele G.
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- 2021
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15. Parent-Perceived Benefits and Harms Associated With Internet Use by Adolescent Offspring
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Kimball, Harry Graff, primary, Fernandez, Francesca, additional, Moskowitz, Kathleen Anne, additional, Kang, Minji, additional, Alexander, Lindsay M., additional, Conway, Kevin P., additional, Merikangas, Kathleen Ries, additional, Salum, Giovanni Abrahão, additional, and Milham, Michael Peter, additional
- Published
- 2023
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16. Gene expression changes associated with trajectories of psychopathology in a longitudinal cohort of children and adolescents
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Ota, Vanessa Kiyomi, Santoro, Marcos Leite, Spindola, Leticia Maria, Pan, Pedro Mario, Simabucuro, Andressa, Xavier, Gabriela, Vieira-Fonseca, Tamiris, Zanardo, Evelin Aline, dos Santos, Felipe Rodolfo Camargo, Schäfer, Julia Luiza, Kulikowski, Leslie Domenici, Galante, Pedro A. F., Asprino, Paula Fontes, Brietzke, Elisa, Grassi-Oliveira, Rodrigo, Rohde, Luis Augusto, Miguel, Euripedes Constantino, Gadelha, Ary, Mari, Jair Jesus, Bressan, Rodrigo Affonseca, Salum, Giovanni Abrahao, and Belangero, Sintia Iole
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- 2020
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17. Parental Preferences for Mental Health Screening of Youths From a Multinational Survey
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Kass, Mirelle, primary, Alexander, Lindsay, additional, Moskowitz, Kathleen, additional, James, Najé, additional, Salum, Giovanni Abrahão, additional, Leventhal, Bennett, additional, Merikangas, Kathleen, additional, and Milham, Michael Peter, additional
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- 2023
- Full Text
- View/download PDF
18. Problematic internet use in children and adolescents: associations with psychiatric disorders and impairment
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Restrepo, Anita, Scheininger, Tohar, Clucas, Jon, Alexander, Lindsay, Salum, Giovanni A., Georgiades, Kathy, Paksarian, Diana, Merikangas, Kathleen R., and Milham, Michael P.
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- 2020
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19. Translating measurement into practice: Brazilian norms for depressive symptom assessment with the Patient Health Questionnaire (PHQ-9)
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Damiano, Rodolfo Furlan, Hoffmann, Maurício Scopel, Gosmann, Natan Pereira, Pan, Pedro Mario, Miguel, Eurípedes Constantino, and Salum, Giovanni Abrahão
- Subjects
Psychometrics ,community psychiatry ,measurement-based care ,depression severity - Abstract
Objectives: To provide practical norms for measuring depressive symptoms with the Patient Health Questionnaire 9 (PHQ-9) in Brazil through a state-of-the-art psychometrics analysis. Methods: We used a large representative dataset from the 2019 Brazilian National Health Survey (Pesquisa Nacional de Saúde – 2019), which included 90,846 Brazilian citizens. To assess scale structure, we assessed a unidimensional model using confirmatory factor analysis. Item response theory was used to characterize the distribution of depressive symptoms. Summed- and mean-based PHQ-9 scores were then linked using item response theory-based scores in generalized additive models. Finally, percentiles, T scores, and a newly developed score, called the decimal score (D score), were generated to describe PHQ-9 norms for the Brazilian population. Results: Confirmatory factor analysis revealed a good fit to the unidimensional model, being invariant to age and sex. Item response theory captured item-level information about the latent trait (reliable from 1 to 3 SDs above the mean). Brazilian norms were presented using summed scores, T scores, and D scores. Conclusion: This is the first study to determine Brazilian norms for the PHQ-9 among a large representative sample using robust psychometric tools. More precise PHQ-9 scores are now available and may be widely used in primary and specialized clinical care settings.
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- 2023
20. Diagnostic operationalization and phenomenological heterogeneity in psychiatry: the case of attention deficit hyperactivity disorder
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Salum, Giovanni Abrahao, Gadelha, Ary, Polanczyk, Guilherme Vanoni, Miguel, Euripedes Constantino, and Rohde, Luis Augusto
- Published
- 2018
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21. Selective serotonin reuptake inhibitors, and serotonin and norepinephrine reuptake inhibitors for anxiety, obsessive-compulsive, and stress disorders: A 3-level network meta-analysis
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Gosmann, Natan Pereira, Costa, Marianna de Abreu, Jaeger, Marianna de Barros, Motta, Luis Souza, Frozi, Júlia, Spanemberg, Lucas, Manfro, Gisele Gus, Cuijpers, Pim, Pine, Daniel Samuel, and Salum, Giovanni Abrahão
- Subjects
Noradrenaline -- Usage -- Patient outcomes ,Obsessive-compulsive disorder -- Drug therapy -- Patient outcomes ,Serotonin uptake inhibitors -- Usage -- Patient outcomes ,Serotonin agonists -- Usage -- Patient outcomes ,Post-traumatic stress disorder -- Drug therapy -- Patient outcomes ,Anxiety -- Drug therapy -- Patient outcomes ,Biological sciences - Abstract
Background Anxiety, obsessive-compulsive, and stress-related disorders frequently co-occur, and patients often present symptoms of several domains. Treatment involves the use of selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs), but data on comparative efficacy and acceptability are lacking. We aimed to compare the efficacy of SSRIs, SNRIs, and placebo in multiple symptom domains in patients with these diagnoses over the lifespan through a 3-level network meta-analysis. Methods and findings We searched for published and unpublished randomized controlled trials that aimed to assess the efficacy of SSRIs or SNRIs in participants (adults and children) with diagnosis of any anxiety, obsessive-compulsive, or stress-related disorder in MEDLINE, PsycINFO, Embase, and Cochrane Library from inception to 23 April 2015, with an update on 11 November 2020. We supplemented electronic database searches with manual searches for published and unpublished randomized controlled trials registered in publicly accessible clinical trial registries and pharmaceutical companies' databases. No restriction was made regarding comorbidities with any other mental disorder, participants' age and sex, blinding of participants and researchers, date of publication, or study language. The primary outcome was the aggregate measure of internalizing symptoms of these disorders. Secondary outcomes included specific symptom domains and treatment discontinuation rate. We estimated standardized mean differences (SMDs) with 3-level network meta-analysis with random slopes by study for medication and assessment instrument. Risk of bias appraisal was performed using the Cochrane Collaboration's risk of bias tool. This study was registered in PROSPERO (CRD42017069090). We analyzed 469 outcome measures from 135 studies (n = 30,245). All medications were more effective than placebo for the aggregate measure of internalizing symptoms (SMD -0.56, 95% CI -0.62 to -0.51, p < 0.001), for all symptom domains, and in patients from all diagnostic categories. We also found significant results when restricting to the most used assessment instrument for each diagnosis; nevertheless, this restriction led to exclusion of 72.71% of outcome measures. Pairwise comparisons revealed only small differences between medications in efficacy and acceptability. Limitations include the moderate heterogeneity found in most outcomes and the moderate risk of bias identified in most of the trials. Conclusions In this study, we observed that all SSRIs and SNRIs were effective for multiple symptom domains, and in patients from all included diagnostic categories. We found minimal differences between medications concerning efficacy and acceptability. This three-level network meta-analysis contributes to an ongoing discussion about the true benefit of antidepressants with robust evidence, considering the significantly larger quantity of data and higher statistical power when compared to previous studies. The 3-level approach allowed us to properly assess the efficacy of these medications on internalizing psychopathology, avoiding potential biases related to the exclusion of information due to distinct assessment instruments, and to explore the multilevel structure of transdiagnostic efficacy., Author(s): Natan Pereira Gosmann 1,2,*, Marianna de Abreu Costa 2, Marianna de Barros Jaeger 2, Luis Souza Motta 1, Júlia Frozi 1, Lucas Spanemberg 1,3, Gisele Gus Manfro 2, Pim [...]
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- 2021
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22. Country-level gender inequality is associated with structural differences in the brains of women and men
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Zugman, André, Alliende, Luz María, Medel, Vicente, Bethlehem, Richard A.I., Seidlitz, Jakob, Ringlein, Grace, Arango, Celso, Arnatkevičiūtė, Aurina, Asmal, Laila, Bellgrove, Mark, Benegal, Vivek, Bernardo, Miquel, Billeke, Pablo, Bosch-Bayard, Jorge, Bressan, Rodrigo, Busatto, Geraldo F., Castro, Mariana N., Chaim-Avancini, Tiffany, Compte, Albert, Costanzi, Monise, Czepielewski, Leticia, Dazzan, Paola, de la Fuente-Sandoval, Camilo, Di Forti, Marta, Díaz-Caneja, Covadonga M., María Díaz-Zuluaga, Ana, Du Plessis, Stefan, Duran, Fabio L. S., Fittipaldi, Sol, Fornito, Alex, Freimer, Nelson B., Gadelha, Ary, Gama, Clarissa S., Garani, Ranjini, Garcia-Rizo, Clemente, Gonzalez Campo, Cecilia, Gonzalez-Valderrama, Alfonso, Guinjoan, Salvador, Holla, Bharath, Ibañez, Agustín, Ivanovic, Daniza, Jackowski, Andrea, Leon-Ortiz, Pablo, Lochner, Christine, López-Jaramillo, Carlos, Luckhoff, Hilmar, Massuda, Raffael, McGuire, Philip, Miyata, Jun, Mizrahi, Romina, Murray, Robin, Ozerdem, Aysegul, Pan, Pedro M., Parellada, Mara, Phahladira, Lebogan, Ramirez-Mahaluf, Juan P., Reckziegel, Ramiro, Reis Marques, Tiago, Reyes-Madrigal, Francisco, Roos, Annerine, Rosa, Pedro, Salum, Giovanni, Scheffler, Freda, Schumann, Gunter, Serpa, Mauricio, Stein, Dan J., Tepper, Angeles, Tiego, Jeggan, Ueno, Tsukasa, Undurraga, Juan, Undurraga, Eduardo A., Valdes-Sosa, Pedro, Valli, Isabel, Villarreal, Mirta, Winton-Brown, Toby T., Yalin, Nefize, Zamorano, Francisco, Zanetti, Marcus V., cVEDA, Winkler, Anderson M., Pine, Daniel S., Evans-Lacko, Sara, Crossley, Nicolas A., Zugman, André, Alliende, Luz María, Medel, Vicente, Bethlehem, Richard A.I., Seidlitz, Jakob, Ringlein, Grace, Arango, Celso, Arnatkevičiūtė, Aurina, Asmal, Laila, Bellgrove, Mark, Benegal, Vivek, Bernardo, Miquel, Billeke, Pablo, Bosch-Bayard, Jorge, Bressan, Rodrigo, Busatto, Geraldo F., Castro, Mariana N., Chaim-Avancini, Tiffany, Compte, Albert, Costanzi, Monise, Czepielewski, Leticia, Dazzan, Paola, de la Fuente-Sandoval, Camilo, Di Forti, Marta, Díaz-Caneja, Covadonga M., María Díaz-Zuluaga, Ana, Du Plessis, Stefan, Duran, Fabio L. S., Fittipaldi, Sol, Fornito, Alex, Freimer, Nelson B., Gadelha, Ary, Gama, Clarissa S., Garani, Ranjini, Garcia-Rizo, Clemente, Gonzalez Campo, Cecilia, Gonzalez-Valderrama, Alfonso, Guinjoan, Salvador, Holla, Bharath, Ibañez, Agustín, Ivanovic, Daniza, Jackowski, Andrea, Leon-Ortiz, Pablo, Lochner, Christine, López-Jaramillo, Carlos, Luckhoff, Hilmar, Massuda, Raffael, McGuire, Philip, Miyata, Jun, Mizrahi, Romina, Murray, Robin, Ozerdem, Aysegul, Pan, Pedro M., Parellada, Mara, Phahladira, Lebogan, Ramirez-Mahaluf, Juan P., Reckziegel, Ramiro, Reis Marques, Tiago, Reyes-Madrigal, Francisco, Roos, Annerine, Rosa, Pedro, Salum, Giovanni, Scheffler, Freda, Schumann, Gunter, Serpa, Mauricio, Stein, Dan J., Tepper, Angeles, Tiego, Jeggan, Ueno, Tsukasa, Undurraga, Juan, Undurraga, Eduardo A., Valdes-Sosa, Pedro, Valli, Isabel, Villarreal, Mirta, Winton-Brown, Toby T., Yalin, Nefize, Zamorano, Francisco, Zanetti, Marcus V., cVEDA, Winkler, Anderson M., Pine, Daniel S., Evans-Lacko, Sara, and Crossley, Nicolas A.
- Abstract
Gender inequality across the world has been associated with a higher risk to mental health problems and lower academic achievement in women compared to men. We also know that the brain is shaped by nurturing and adverse socio-environmental experiences. Therefore, unequal exposure to harsher conditions for women compared to men in gender-unequal countries might be reflected in differences in their brain structure, and this could be the neural mechanism partly explaining women’s worse outcomes in gender-unequal countries. We examined this through a random-effects meta-analysis on cortical thickness and surface area differences between adult healthy men and women, including a meta-regression in which country-level gender inequality acted as an explanatory variable for the observed differences. A total of 139 samples from 29 different countries, totaling 7, 876 MRI scans, were included. Thickness of the right hemisphere, and particularly the right caudal anterior cingulate, right medial orbitofrontal, and left lateral occipital cortex, presented no differences or even thicker regional cortices in women compared to men in gender-equal countries, reversing to thinner cortices in countries with greater gender inequality. These results point to the potentially hazardous effect of gender inequality on women’s brains and provide initial evidence for neuroscience-informed policies for gender equality.
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- 2023
23. Volume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group
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UCL - SSH/IPSY - Psychological Sciences Research Institute, UCL - SSS/IONS/NEUR - Clinical Neuroscience, Groenewold, Nynke A., Bas-Hoogendam, Janna Marie, Amod, Alyssa R., Laansma, Max A., Van Velzen, Laura S., Aghajani, Moji, Hilbert, Kevin, Oh, Hyuntaek, Salas, Ramiro, Jackowski, Andrea P., Pan, Pedro M., Salum, Giovanni A., Blair, James R., Blair, Karina S., Hirsch, Joy, Pantazatos, Spiro P., Schneier, Franklin R., Talati, Ardesheer, Roelofs, Karin, Volman, Inge, Blanco-Hinojo, Laura, Cardoner, Narcís, Pujol, Jesus, Beesdo-Baum, Katja, Ching, Christopher R. K., Thomopoulos, Sophia I., Jansen, Andreas, Kircher, Tilo, Krug, Axel, Nenadić, Igor, Stein, Frederike, Dannlowski, Udo, Grotegerd, Dominik, Lemke, Hannah, Meinert, Susanne, Winter, Alexandra, Erb, Michael, Kreifelts, Benjamin, Gong, Qiyong, Lui, Su, Zhu, Fei, Mwangi, Benson, Soares, Jair C., Wu, Mon-Ju, Bayram, Ali, Canli, Mesut, Tükel, Raşit, Westenberg, P. Michiel, Heeren, Alexandre, Cremers, Henk R., Hofmann, David, Straube, Thomas, Doruyter, Alexander G. G., Lochner, Christine, Peterburs, Jutta, Van Tol, Marie-José, Gur, Raquel E., Kaczkurkin, Antonia N., Larsen, Bart, Satterthwaite, Theodore D., Filippi, Courtney A., Gold, Andrea L., Harrewijn, Anita, Zugman, André, Bülow, Robin, Grabe, Hans J., Völzke, Henry, Wittfeld, Katharina, Böhnlein, Joscha, Dohm, Katharina, Kugel, Harald, Schrammen, Elisabeth, Zwanzger, Peter, Leehr, Elisabeth J., Sindermann, Lisa, Ball, Tali M., Fonzo, Gregory A., Paulus, Martin P., Simmons, Alan, Stein, Murray B., Klumpp, Heide, Phan, K. Luan, Furmark, Tomas, Månsson, Kristoffer N. T., Manzouri, Amirhossein, Avery, Suzanne N., Blackford, Jennifer Urbano, Clauss, Jacqueline A., Feola, Brandee, Harper, Jennifer C., Sylvester, Chad M., Lueken, Ulrike, Veltman, Dick J., Winkler, Anderson M., Jahanshad, Neda, Pine, Daniel S., Thompson, Paul M., Stein, Dan J., Van der Wee, Nic J. A., UCL - SSH/IPSY - Psychological Sciences Research Institute, UCL - SSS/IONS/NEUR - Clinical Neuroscience, Groenewold, Nynke A., Bas-Hoogendam, Janna Marie, Amod, Alyssa R., Laansma, Max A., Van Velzen, Laura S., Aghajani, Moji, Hilbert, Kevin, Oh, Hyuntaek, Salas, Ramiro, Jackowski, Andrea P., Pan, Pedro M., Salum, Giovanni A., Blair, James R., Blair, Karina S., Hirsch, Joy, Pantazatos, Spiro P., Schneier, Franklin R., Talati, Ardesheer, Roelofs, Karin, Volman, Inge, Blanco-Hinojo, Laura, Cardoner, Narcís, Pujol, Jesus, Beesdo-Baum, Katja, Ching, Christopher R. K., Thomopoulos, Sophia I., Jansen, Andreas, Kircher, Tilo, Krug, Axel, Nenadić, Igor, Stein, Frederike, Dannlowski, Udo, Grotegerd, Dominik, Lemke, Hannah, Meinert, Susanne, Winter, Alexandra, Erb, Michael, Kreifelts, Benjamin, Gong, Qiyong, Lui, Su, Zhu, Fei, Mwangi, Benson, Soares, Jair C., Wu, Mon-Ju, Bayram, Ali, Canli, Mesut, Tükel, Raşit, Westenberg, P. Michiel, Heeren, Alexandre, Cremers, Henk R., Hofmann, David, Straube, Thomas, Doruyter, Alexander G. G., Lochner, Christine, Peterburs, Jutta, Van Tol, Marie-José, Gur, Raquel E., Kaczkurkin, Antonia N., Larsen, Bart, Satterthwaite, Theodore D., Filippi, Courtney A., Gold, Andrea L., Harrewijn, Anita, Zugman, André, Bülow, Robin, Grabe, Hans J., Völzke, Henry, Wittfeld, Katharina, Böhnlein, Joscha, Dohm, Katharina, Kugel, Harald, Schrammen, Elisabeth, Zwanzger, Peter, Leehr, Elisabeth J., Sindermann, Lisa, Ball, Tali M., Fonzo, Gregory A., Paulus, Martin P., Simmons, Alan, Stein, Murray B., Klumpp, Heide, Phan, K. Luan, Furmark, Tomas, Månsson, Kristoffer N. T., Manzouri, Amirhossein, Avery, Suzanne N., Blackford, Jennifer Urbano, Clauss, Jacqueline A., Feola, Brandee, Harper, Jennifer C., Sylvester, Chad M., Lueken, Ulrike, Veltman, Dick J., Winkler, Anderson M., Jahanshad, Neda, Pine, Daniel S., Thompson, Paul M., Stein, Dan J., and Van der Wee, Nic J. A.
- Abstract
There is limited convergence in neuroimaging investigations into volumes of subcortical brain regions in social anxiety disorder (SAD). The inconsistent findings may arise from variations in methodological approaches across studies, including sample selection based on age and clinical characteristics. The ENIGMA-Anxiety Working Group initiated a global mega-analysis to determine whether differences in subcortical volumes can be detected in adults and adolescents with SAD relative to healthy controls. Volumetric data from 37 international samples with 1115 SAD patients and 2775 controls were obtained from ENIGMA-standardized protocols for image segmentation and quality assurance. Linear mixed-effects analyses were adjusted for comparisons across seven subcortical regions in each hemisphere using family-wise error (FWE)-correction. Mixed-effects d effect sizes were calculated. In the full sample, SAD patients showed smaller bilateral putamen volume than controls (left: d = −0.077, pFWE = 0.037; right: d = −0.104, pFWE = 0.001), and a significant interaction between SAD and age was found for the left putamen (r = −0.034, pFWE = 0.045). Smaller bilateral putamen volumes (left: d = −0.141, pFWE < 0.001; right: d = −0.158, pFWE < 0.001) and larger bilateral pallidum volumes (left: d = 0.129, pFWE = 0.006; right: d = 0.099, pFWE = 0.046) were detected in adult SAD patients relative to controls, but no volumetric differences were apparent in adolescent SAD patients relative to controls. Comorbid anxiety disorders and age of SAD onset were additional determinants of SAD-related volumetric differences in subcortical regions. To conclude, subtle volumetric alterations in subcortical regions in SAD were detected. Heterogeneity in age and clinical characteristics may partly explain inconsistencies in previous findings. The association between alterations in subcortical volumes and SAD illness progression deserves further investigation, especially from adolescence into adulthood.
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- 2023
24. Volume of subcortical brain regions in social anxiety disorder : mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group
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Groenewold, Nynke A., Bas-Hoogendam, Janna Marie, Amod, Alyssa R., Laansma, Max A., Van Velzen, Laura S., Aghajani, Moji, Hilbert, Kevin, Oh, Hyuntaek, Salas, Ramiro, Jackowski, Andrea P., Pan, Pedro M., Salum, Giovanni A., Blair, James R., Blair, Karina S., Hirsch, Joy, Pantazatos, Spiro P., Schneier, Franklin R., Talati, Ardesheer, Roelofs, Karin, Volman, Inge, Blanco-Hinojo, Laura, Cardoner, Narcís, Pujol, Jesus, Beesdo-Baum, Katja, Ching, Christopher R. K., Thomopoulos, Sophia I., Jansen, Andreas, Kircher, Tilo, Krug, Axel, Nenadić, Igor, Stein, Frederike, Dannlowski, Udo, Grotegerd, Dominik, Lemke, Hannah, Meinert, Susanne, Winter, Alexandra, Erb, Michael, Kreifelts, Benjamin, Gong, Qiyong, Lui, Su, Zhu, Fei, Mwangi, Benson, Soares, Jair C., Wu, Mon-Ju, Bayram, Ali, Canli, Mesut, Tükel, Raşit, Westenberg, P. Michiel, Heeren, Alexandre, Cremers, Henk R., Hofmann, David, Straube, Thomas, Doruyter, Alexander G. G., Lochner, Christine, Peterburs, Jutta, Van Tol, Marie-José, Gur, Raquel E., Kaczkurkin, Antonia N., Larsen, Bart, Satterthwaite, Theodore D., Filippi, Courtney A., Gold, Andrea L., Harrewijn, Anita, Zugman, André, Bülow, Robin, Grabe, Hans J., Völzke, Henry, Wittfeld, Katharina, Böhnlein, Joscha, Dohm, Katharina, Kugel, Harald, Schrammen, Elisabeth, Zwanzger, Peter, Leehr, Elisabeth J., Sindermann, Lisa, Ball, Tali M., Fonzo, Gregory A., Paulus, Martin P., Simmons, Alan, Stein, Murray B., Klumpp, Heide, Phan, K. Luan, Furmark, Tomas, Månsson, Kristoffer N. T., Manzouri, Amirhossein, Avery, Suzanne N., Blackford, Jennifer Urbano, Clauss, Jacqueline A., Feola, Brandee, Harper, Jennifer C., Sylvester, Chad M., Lueken, Ulrike, Veltman, Dick J., Winkler, Anderson M., Jahanshad, Neda, Pine, Daniel S., Thompson, Paul M., Stein, Dan J., Van der Wee, Nic J. A., Groenewold, Nynke A., Bas-Hoogendam, Janna Marie, Amod, Alyssa R., Laansma, Max A., Van Velzen, Laura S., Aghajani, Moji, Hilbert, Kevin, Oh, Hyuntaek, Salas, Ramiro, Jackowski, Andrea P., Pan, Pedro M., Salum, Giovanni A., Blair, James R., Blair, Karina S., Hirsch, Joy, Pantazatos, Spiro P., Schneier, Franklin R., Talati, Ardesheer, Roelofs, Karin, Volman, Inge, Blanco-Hinojo, Laura, Cardoner, Narcís, Pujol, Jesus, Beesdo-Baum, Katja, Ching, Christopher R. K., Thomopoulos, Sophia I., Jansen, Andreas, Kircher, Tilo, Krug, Axel, Nenadić, Igor, Stein, Frederike, Dannlowski, Udo, Grotegerd, Dominik, Lemke, Hannah, Meinert, Susanne, Winter, Alexandra, Erb, Michael, Kreifelts, Benjamin, Gong, Qiyong, Lui, Su, Zhu, Fei, Mwangi, Benson, Soares, Jair C., Wu, Mon-Ju, Bayram, Ali, Canli, Mesut, Tükel, Raşit, Westenberg, P. Michiel, Heeren, Alexandre, Cremers, Henk R., Hofmann, David, Straube, Thomas, Doruyter, Alexander G. G., Lochner, Christine, Peterburs, Jutta, Van Tol, Marie-José, Gur, Raquel E., Kaczkurkin, Antonia N., Larsen, Bart, Satterthwaite, Theodore D., Filippi, Courtney A., Gold, Andrea L., Harrewijn, Anita, Zugman, André, Bülow, Robin, Grabe, Hans J., Völzke, Henry, Wittfeld, Katharina, Böhnlein, Joscha, Dohm, Katharina, Kugel, Harald, Schrammen, Elisabeth, Zwanzger, Peter, Leehr, Elisabeth J., Sindermann, Lisa, Ball, Tali M., Fonzo, Gregory A., Paulus, Martin P., Simmons, Alan, Stein, Murray B., Klumpp, Heide, Phan, K. Luan, Furmark, Tomas, Månsson, Kristoffer N. T., Manzouri, Amirhossein, Avery, Suzanne N., Blackford, Jennifer Urbano, Clauss, Jacqueline A., Feola, Brandee, Harper, Jennifer C., Sylvester, Chad M., Lueken, Ulrike, Veltman, Dick J., Winkler, Anderson M., Jahanshad, Neda, Pine, Daniel S., Thompson, Paul M., Stein, Dan J., and Van der Wee, Nic J. A.
- Abstract
There is limited convergence in neuroimaging investigations into volumes of subcortical brain regions in social anxiety disorder (SAD). The inconsistent findings may arise from variations in methodological approaches across studies, including sample selection based on age and clinical characteristics. The ENIGMA-Anxiety Working Group initiated a global mega-analysis to determine whether differences in subcortical volumes can be detected in adults and adolescents with SAD relative to healthy controls. Volumetric data from 37 international samples with 1115 SAD patients and 2775 controls were obtained from ENIGMA-standardized protocols for image segmentation and quality assurance. Linear mixed-effects analyses were adjusted for comparisons across seven subcortical regions in each hemisphere using family-wise error (FWE)-correction. Mixed-effects d effect sizes were calculated. In the full sample, SAD patients showed smaller bilateral putamen volume than controls (left: d = −0.077, pFWE = 0.037; right: d = −0.104, pFWE = 0.001), and a significant interaction between SAD and age was found for the left putamen (r = −0.034, pFWE = 0.045). Smaller bilateral putamen volumes (left: d = −0.141, pFWE < 0.001; right: d = −0.158, pFWE < 0.001) and larger bilateral pallidum volumes (left: d = 0.129, pFWE = 0.006; right: d = 0.099, pFWE = 0.046) were detected in adult SAD patients relative to controls, but no volumetric differences were apparent in adolescent SAD patients relative to controls. Comorbid anxiety disorders and age of SAD onset were additional determinants of SAD-related volumetric differences in subcortical regions. To conclude, subtle volumetric alterations in subcortical regions in SAD were detected. Heterogeneity in age and clinical characteristics may partly explain inconsistencies in previous findings. The association between alterations in subcortical volumes and SAD illness progression deserves further investigation, especially from adolescence into adul
- Published
- 2023
- Full Text
- View/download PDF
25. Incidence of adverse events and comparative tolerability of selective serotonin reuptake inhibitors, and serotonin and norepinephrine reuptake inhibitors for the treatment of anxiety, obsessive-compulsive, and stress disorders: A systematic review and network meta-analysis
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Gosmann, Natan Pereira, Costa, Marianna De Abreu, Jaeger, Marianna De Barros, Frozi, Júlia, Spanemberg, Lucas, Manfro, Gisele Gus, Cortese, Samuele, Cuijpers, Pim, Pine, Daniel Samuel, Salum, Giovanni Abrahão, Gosmann, Natan Pereira, Costa, Marianna De Abreu, Jaeger, Marianna De Barros, Frozi, Júlia, Spanemberg, Lucas, Manfro, Gisele Gus, Cortese, Samuele, Cuijpers, Pim, Pine, Daniel Samuel, and Salum, Giovanni Abrahão
- Abstract
Selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) show similar efficacy as treatments for anxiety, obsessive-compulsive, and stress-related disorders. Hence, comparisons of adverse event rates across medications are an essential component of clinical decision-making. We aimed to compare patterns of adverse events associated with SSRIs and SNRIs in the treatment of children and adults diagnosed with these disorders through a network meta-analysis. We searched MEDLINE, PsycINFO, Embase, Cochrane, websites of regulatory agencies, and international registers from inception to 09 September 2022, for randomized controlled trials assessing the efficacy of SSRIs or SNRIs. We analyzed the proportion of participants experiencing at least one adverse event and incidence rates of 17 specific adverse events. We estimated incidence rates and odds ratios through network meta-analysis with random effects and three-level models. We analyzed 799 outcome measures from 80 studies (n = 21 338). Participants in medication groups presented higher rates of adverse events (80.22%, 95% CI 76.13-83.76) when compared to placebo groups (71.21%, 67.00-75.09). Nausea was the most common adverse event (25.71%, CI 23.96-27.54), while weight change was the least common (3.56%, 1.68-7.37). We found higher rates of adverse events of medications over placebo for most medications, except sertraline and fluoxetine. We found significant differences between medications for overall tolerability and for autonomic, gastrointestinal, and sleep-related symptoms. Adverse events are a common reason that patients discontinue SSRIs and SNRIs. Results presented here guide clinical decision-making when clinicians weigh one medication over another. This might improve treatment acceptability and compliance.
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- 2023
- Full Text
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26. Volume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group
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Groenewold, Nynke A, Bas-Hoogendam, Janna Marie, Amod, Alyssa R, Laansma, Max A, Van Velzen, Laura S, Aghajani, Moji, Hilbert, Kevin, Oh, Hyuntaek, Salas, Ramiro, Jackowski, Andrea P, Pan, Pedro M, Salum, Giovanni A, Blair, James R, Blair, Karina S, Hirsch, Joy, Pantazatos, Spiro P, Schneier, Franklin R, Talati, Ardesheer, Roelofs, Karin, Volman, Inge, Blanco-Hinojo, Laura, Cardoner, Narcís, Pujol, Jesus, Beesdo-Baum, Katja, Ching, Christopher R K, Thomopoulos, Sophia I, Jansen, Andreas, Kircher, Tilo, Krug, Axel, Nenadić, Igor, Stein, Frederike, Dannlowski, Udo, Grotegerd, Dominik, Lemke, Hannah, Meinert, Susanne, Winter, Alexandra, Erb, Michael, Kreifelts, Benjamin, Gong, Qiyong, Lui, Su, Zhu, Fei, Mwangi, Benson, Soares, Jair C, Wu, Mon-Ju, Bayram, Ali, Canli, Mesut, Tükel, Raşit, Westenberg, P Michiel, Heeren, Alexandre, Cremers, Henk R, Hofmann, David, Straube, Thomas, Doruyter, Alexander G G, Lochner, Christine, Peterburs, Jutta, Van Tol, Marie-José, Gur, Raquel E, Kaczkurkin, Antonia N, Larsen, Bart, Satterthwaite, Theodore D, Filippi, Courtney A, Gold, Andrea L, Harrewijn, Anita, Zugman, André, Bülow, Robin, Grabe, Hans J, Völzke, Henry, Wittfeld, Katharina, Böhnlein, Joscha, Dohm, Katharina, Kugel, Harald, Schrammen, Elisabeth, Zwanzger, Peter, Leehr, Elisabeth J, Sindermann, Lisa, Ball, Tali M, Fonzo, Gregory A, Paulus, Martin P, Simmons, Alan, Stein, Murray B, Klumpp, Heide, Phan, K Luan, Furmark, Tomas, Månsson, Kristoffer N T, Manzouri, Amirhossein, Avery, Suzanne N, Blackford, Jennifer Urbano, Clauss, Jacqueline A, Feola, Brandee, Harper, Jennifer C, Sylvester, Chad M, Lueken, Ulrike, Veltman, Dick J, Winkler, Anderson M, Jahanshad, Neda, Pine, Daniel S, Thompson, Paul M, Stein, Dan J, Van der Wee, Nic J A, Groenewold, Nynke A, Bas-Hoogendam, Janna Marie, Amod, Alyssa R, Laansma, Max A, Van Velzen, Laura S, Aghajani, Moji, Hilbert, Kevin, Oh, Hyuntaek, Salas, Ramiro, Jackowski, Andrea P, Pan, Pedro M, Salum, Giovanni A, Blair, James R, Blair, Karina S, Hirsch, Joy, Pantazatos, Spiro P, Schneier, Franklin R, Talati, Ardesheer, Roelofs, Karin, Volman, Inge, Blanco-Hinojo, Laura, Cardoner, Narcís, Pujol, Jesus, Beesdo-Baum, Katja, Ching, Christopher R K, Thomopoulos, Sophia I, Jansen, Andreas, Kircher, Tilo, Krug, Axel, Nenadić, Igor, Stein, Frederike, Dannlowski, Udo, Grotegerd, Dominik, Lemke, Hannah, Meinert, Susanne, Winter, Alexandra, Erb, Michael, Kreifelts, Benjamin, Gong, Qiyong, Lui, Su, Zhu, Fei, Mwangi, Benson, Soares, Jair C, Wu, Mon-Ju, Bayram, Ali, Canli, Mesut, Tükel, Raşit, Westenberg, P Michiel, Heeren, Alexandre, Cremers, Henk R, Hofmann, David, Straube, Thomas, Doruyter, Alexander G G, Lochner, Christine, Peterburs, Jutta, Van Tol, Marie-José, Gur, Raquel E, Kaczkurkin, Antonia N, Larsen, Bart, Satterthwaite, Theodore D, Filippi, Courtney A, Gold, Andrea L, Harrewijn, Anita, Zugman, André, Bülow, Robin, Grabe, Hans J, Völzke, Henry, Wittfeld, Katharina, Böhnlein, Joscha, Dohm, Katharina, Kugel, Harald, Schrammen, Elisabeth, Zwanzger, Peter, Leehr, Elisabeth J, Sindermann, Lisa, Ball, Tali M, Fonzo, Gregory A, Paulus, Martin P, Simmons, Alan, Stein, Murray B, Klumpp, Heide, Phan, K Luan, Furmark, Tomas, Månsson, Kristoffer N T, Manzouri, Amirhossein, Avery, Suzanne N, Blackford, Jennifer Urbano, Clauss, Jacqueline A, Feola, Brandee, Harper, Jennifer C, Sylvester, Chad M, Lueken, Ulrike, Veltman, Dick J, Winkler, Anderson M, Jahanshad, Neda, Pine, Daniel S, Thompson, Paul M, Stein, Dan J, and Van der Wee, Nic J A
- Abstract
There is limited convergence in neuroimaging investigations into volumes of subcortical brain regions in social anxiety disorder (SAD). The inconsistent findings may arise from variations in methodological approaches across studies, including sample selection based on age and clinical characteristics. The ENIGMA-Anxiety Working Group initiated a global mega-analysis to determine whether differences in subcortical volumes can be detected in adults and adolescents with SAD relative to healthy controls. Volumetric data from 37 international samples with 1115 SAD patients and 2775 controls were obtained from ENIGMA-standardized protocols for image segmentation and quality assurance. Linear mixed-effects analyses were adjusted for comparisons across seven subcortical regions in each hemisphere using family-wise error (FWE)-correction. Mixed-effects d effect sizes were calculated. In the full sample, SAD patients showed smaller bilateral putamen volume than controls (left: d = -0.077, p FWE = 0.037; right: d = -0.104, p FWE = 0.001), and a significant interaction between SAD and age was found for the left putamen (r = -0.034, p FWE = 0.045). Smaller bilateral putamen volumes (left: d = -0.141, p FWE < 0.001; right: d = -0.158, p FWE < 0.001) and larger bilateral pallidum volumes (left: d = 0.129, p FWE = 0.006; right: d = 0.099, p FWE = 0.046) were detected in adult SAD patients relative to controls, but no volumetric differences were apparent in adolescent SAD patients relative to controls. Comorbid anxiety disorders and age of SAD onset were additional determinants of SAD-related volumetric differences in subcortical regions. To conclude, subtle volumetric alterations in subcortical regions in SAD were detected. Heterogeneity in age and clinical characteristics may partly explain inconsistencies in previous findings. The association between alterations in subcortical volumes and SAD illness progression deserves further investigation, especially from adol
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- 2023
27. Genetic variants associated with longitudinal changes in brain structure across the lifespan
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Brouwer, Rachel M, Klein, Marieke, Kremen, William S, Guimaraes, Joao P O F T, Homuth, Georg, Hottenga, Jouke-Jan, Knol, Maria J, Kwok, John B J, Le Hellard, Stephanie, Mather, Karen A, Milaneschi, Yuri, Morris, Derek W, Nöthen, Markus M., Panizzon, Matthew S, Papiol, Sergi, Rietschel, Marcella, Santoro, Marcos L, Steen, Vidar M, Stein, Jason L, Streit, Fabian, Tankard, Rick M, Teumer, Alexander, van 't Ent, Dennis, van der Meer, Dennis, Olde Loohuis, Loes M, van Eijk, Kristel R, Vassos, Evangelos, Vázquez-Bourgon, Javier, Witt, Stephanie H, Consortium, IMAGEN, Adams, Hieab H H, Agartz, Ingrid, Ames, David, Amunts, Katrin, Andreassen, Ole A, Whelan, Christopher D, Arango, Celso, Banaschewski, Tobias, Baune, Bernhard T, Belangero, Sintia I, Bokde, Arun L W, Boomsma, Dorret I, Bressan, Rodrigo A, Brodaty, Henry, Buitelaar, Jan K, Cahn, Wiepke, Aghajani, Moji, Caspers, Svenja, Cichon, Sven, Crespo-Facorro, Benedicto, Cox, Simon R, Dannlowski, Udo, Elvsåshagen, Torbjørn, Espeseth, Thomas, Falkai, Peter, Fisher, Simon E, Flor, Herta, Alloza, Clara, Fullerton, Janice M, Garavan, Hugh, Gowland, Penny A, Grabe, Hans, Hahn, Tim, Heinz, Andreas, Hillegers, Manon, Hoare, Jacqueline, Hoekstra, Pieter J, Ikram, Mohammad A, Alnæs, Dag, Jackowski, Andrea P, Jansen, Andreas, Jönsson, Erik G, Kahn, Rene S, Kircher, Tilo, Korgaonkar, Mayuresh S, Krug, Axel, Lemaitre, Herve, Malt, Ulrik F, Martinot, Jean-Luc, Artiges, Eric, McDonald, Colm, Mitchell, Philip B, Muetzel, Ryan L, Murray, Robin M, Nees, Frauke, Nenadić, Igor, Oosterlaan, Jaap, Ophoff, Roel A, Pan, Pedro M, Penninx, Brenda W J H, Ayesa-Arriola, Rosa, Poustka, Luise, Sachdev, Perminder S, Salum, Giovanni A, Schofield, Peter R, Schumann, Gunter, Shaw, Philip, Sim, Kang, Smolka, Michael N, Stein, Dan J, Trollor, Julian N, Barker, Gareth J, van den Berg, Leonard H, Veldink, Jan H, Walter, Henrik, Westlye, Lars T, Whelan, Robert, White, Tonya, Wright, Margaret J, Medland, Sarah E, Franke, Barbara, Thompson, Paul M, Grasby, Katrina L, Bastin, Mark E, Hulshoff Pol, Hilleke E, Brühl, Rüdiger, Papadopoulos Orfanos, Dimitri, Paus, Tomáš, Millenet, Sabina, Blok, Elisabet, Bøen, Erlend, Breukelaar, Isabella A, Bright, Joanna K, Buimer, Elizabeth E L, Bülow, Robin, Cannon, Dara M, Ciufolini, Simone, Crossley, Nicolas A, Schnack, Hugo G, Damatac, Christienne G, Dazzan, Paola, de Mol, Casper L, de Zwarte, Sonja M C, Desrivières, Sylvane, Díaz-Caneja, Covadonga M, Doan, Nhat Trung, Dohm, Katharina, Fröhner, Juliane H, Goltermann, Janik, Jahanshad, Neda, Grigis, Antoine, Grotegerd, Dominik, Han, Laura K M, Harris, Mathew, Hartman, Catharina A, Heany, Sarah J, Heindel, Walter, Heslenfeld, Dirk J., Hohmann, Sarah, Ittermann, Bernd, Teeuw, Jalmar, Jansen, Philip R, Janssen, Joost, Jia, Tianye, Jiang, Jiyang, Jockwitz, Christiane, Karali, Temmuz, Keeser, Daniel, Koevoets, Martijn G J C, Lenroot, Rhoshel K, Malchow, Berend, Thomopoulos, Sophia I, Mandl, René C W, Medel, Vicente, Meinert, Susanne, Morgan, Catherine A, Mühleisen, Thomas W, Nabulsi, Leila, Opel, Nils, de la Foz, Víctor Ortiz-García, Overs, Bronwyn J, Paillère Martinot, Marie-Laure, Sprooten, Emma, Redlich, Ronny, Marques, Tiago Reis, Repple, Jonathan, Roberts, Gloria, Roshchupkin, Gennady V, Setiaman, Nikita, Shumskaya, Elena, Stein, Frederike, Sudre, Gustavo, Takahashi, Shun, Franz, Carol E, Thalamuthu, Anbupalam, Tordesillas-Gutiérrez, Diana, van der Lugt, Aad, van Haren, Neeltje E M, Wardlaw, Joanna M, Wen, Wei, Westeneng, Henk-Jan, Wittfeld, Katharina, Zhu, Alyssa H, Zugman, Andre, Gogtay, Nitin, Armstrong, Nicola J, Bonfiglio, Gaia, Bralten, Janita, Dalvie, Shareefa, Davies, Gail, Di Forti, Marta, Ding, Linda, Donohoe, Gary, Forstner, Andreas J, Gonzalez-Peñas, Javier, Child and Adolescent Psychiatry / Psychology, Erasmus MC other, Anesthesiology, Epidemiology, Radiology & Nuclear Medicine, Clinical Genetics, Psychiatry, the IMAGEN Consortium, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Human genetics, Amsterdam Neuroscience - Complex Trait Genetics, Pediatric surgery, APH - Aging & Later Life, APH - Mental Health, APH - Digital Health, European Commission, European Research Council, Comunidad de Madrid, Instituto de Salud Carlos III, Fundación Mutua Madrileña, Fundación Alicia Koplowitz, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Clinical Cognitive Neuropsychiatry Research Program (CCNP), Psychiatry 2, RS: MHeNs - R2 - Mental Health, Psychiatrie & Neuropsychologie, Complex Trait Genetics, Cognitive Psychology, Biological Psychology, APH - Health Behaviors & Chronic Diseases, APH - Personalized Medicine, APH - Methodology, Clinical Neuropsychology, IBBA, General Paediatrics, ARD - Amsterdam Reproduction and Development, and Paediatrics
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Neuroinformatics ,EXPRESSION ,Aging ,SUSCEPTIBILITY LOCI ,Longevity ,SURFACE-AREA ,INDIVIDUAL-DIFFERENCES ,All institutes and research themes of the Radboud University Medical Center ,SDG 3 - Good Health and Well-being ,Aging/genetics ,Humans ,ddc:610 ,GENOME-WIDE ASSOCIATION ,METAANALYSIS ,RISK ,Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7] ,General Neuroscience ,220 Statistical Imaging Neuroscience ,Longevity/genetics ,Brain ,Magnetic Resonance Imaging ,genetics [Aging] ,VOLUME ,RELIABILITY ,sense organs ,CORTICAL THICKNESS ,genetics [Longevity] ,Genome-Wide Association Study - Abstract
et al., Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases. In this study, we identified common genetic variants that affect rates of brain growth or atrophy in what is, to our knowledge, the first genome-wide association meta-analysis of changes in brain morphology across the lifespan. Longitudinal magnetic resonance imaging data from 15,640 individuals were used to compute rates of change for 15 brain structures. The most robustly identified genes GPR139, DACH1 and APOE are associated with metabolic processes. We demonstrate global genetic overlap with depression, schizophrenia, cognitive functioning, insomnia, height, body mass index and smoking. Gene set findings implicate both early brain development and neurodegenerative processes in the rates of brain changes. Identifying variants involved in structural brain changes may help to determine biological pathways underlying optimal and dysfunctional brain development and aging., The ENIGMA-Plasticity Working Group is part of the ENIGMA World Aging Center, funded by NIA grants R56 AG058854 and R01 AG058854. The ENIGMA Consortium core funding was supported by NIH Consortium Grant U54 EB020403, supported by a cross-NIH alliance that funds Big Data to Knowledge Centers of Excellence. 1000BRAINS: 1000BRAINS is a population-based cohort based on the Heinz-Nixdorf Recall Study and is supported, in part, by the German National Cohort. We thank the Heinz Nixdorf Foundation (Germany) for their generous support in terms of the Heinz Nixdorf Study. The authors are supported by the Initiative and Networking Fund of the Helmholtz Association (Svenja Caspers) and the European Union’s Horizon 2020 Research and Innovation Programme under grant agreements 785907 (Human Brain Project SGA2; Svenja Caspers, Sven Cichon and Katrin Amunts). This work was further supported by the German Federal Ministry of Education and Research (BMBF) through the Integrated Network IntegraMent (Integrated Understanding of Causes and Mechanisms in Mental Disorders) under the auspices of the e:Med Program (grant 01ZX1314A; Sven Cichon) and by the Swiss National Science Foundation (SNSF, grant 156791; Sven Cichon). The authors acknowledge grants supporting their work from the European Union’s Horizon 2020 Research and Innovation Programme (H2020/2014–2020) under grant agreements 667302 (CoCA), 728018 (Eat2beNICE), 785907 (HBP SGA2) and 772376 (EScORIAL) and the Netherlands ALS Foundation.Additional support is received from the European Community’s Seventh Framework Programme (FP7/2007—2013) under grant agreements n° 602805 (Aggressotype), n° 603016 (MATRICS), n° 602450 (IMAGEMEND) and n° 278948 (TACTICS) and from the European Community’s Horizon 2020 Programme (H2020/2014—2020) under grant agreements n° 643051 (MiND) and n° 667302 (CoCA). FP7 Ideas: the European Research Council (ERC-230374 to D.B.). This work was supported by Spanish Ministry of Science and Innovation, Instituto de Salud Carlos III (SAM16PE07CP1, PI16/02012 and PI19/024), co-financed by ERDF Funds from the European Commission, ‘A way of making Europe’, CIBERSAM; Madrid Regional Government (B2017/BMD-3740 AGES-CM-2), European Union Structural Funds; European Union Seventh Framework Program under grant agreements FP7- HEALTH-2013-2.2.1-2-603196 (Project PSYSCAN) and European Union H2020 Program under the Innovative Medicines Initiative 2 Joint Undertaking (grant agreement 115916, Project PRISM and grant agreement 777394, Project AIMS-2-TRIALS), Fundación Familia Alonso, Fundación Alicia Koplowitz and Fundación Mutua Madrileña. The Horizon 2020 funded ERC Advanced Grant ‘STRATIFY’ (Brain network based stratification of reinforcement-related disorders) (695313). The FP7 project MATRICS (603016). The research leading to these results also received support from the European Community’s Seventh Framework Programme (FP7/2007-2013) under grant agreement 278948 (TACTICS), 602805 (Aggressotype), 603016 (MATRICS) and 602450 (Imagemend) and the Innovation Medicine Initiative grants 115300 (EU-AIMS) and 777394 (AIMS-2-TRIALS).PAFIP: PAFIP was supported by the Instituto de Salud Carlos III (PI14/00639, PI14/00918 and PI17/01056) and Fundación Instituto de Investigación Marqués de Valdecilla (NCT0235832 and NCT025KG Jebsen Stiftelsen and H2020 CoMorMent (847776).34363). European Union Marie Curie Research Training Network (MRTN-CT-2006-035987).
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- 2022
28. Assessing risk of bias in randomized controlled trials of methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD)
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Rodrigues‐Tartari, Raíssa, Swardfager, Walter, Salum, Giovanni A., Rohde, Luís A., and Cogo‐Moreira, Hugo
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- 2018
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29. Detecting multiple differentially methylated CpG sites and regions related to dimensional psychopathology in youths
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Spindola, Leticia M., Santoro, Marcos L., Pan, Pedro M., Ota, Vanessa K., Xavier, Gabriela, Carvalho, Carolina M., Talarico, Fernanda, Sleiman, Patrick, March, Michael, Pellegrino, Renata, Brietzke, Elisa, Grassi-Oliveira, Rodrigo, Mari, Jair J., Gadelha, Ary, Miguel, Euripedes C., Rohde, Luis A., Bressan, Rodrigo A., Mazzotti, Diego R., Sato, João R., Salum, Giovanni A., Hakonarson, Hakon, and Belangero, Sintia I.
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- 2019
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30. Harmonizing bifactor models of psychopathology between distinct assessment instruments: Reliability, measurement invariance, and authenticity.
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Hoffmann, Maurício Scopel, Moore, Tyler Maxwell, Axelrud, Luiza Kvitko, Tottenham, Nim, Rohde, Luis Augusto, Milham, Michael Peter, Satterthwaite, Theodore Daniel, and Salum, Giovanni Abrahão
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CHILD Behavior Checklist ,CONFIRMATORY factor analysis ,DATA harmonization ,PSYCHIATRIC research ,MENTAL health - Abstract
Objectives: Model configuration is important for mental health data harmonization. We provide a method to investigate the performance of different bifactor model configurations to harmonize different instruments. Methods: We used data from six samples from the Reproducible Brain Charts initiative (N = 8,606, ages 5–22 years, 41.0% females). We harmonized items from two psychopathology instruments, Child Behavior Checklist (CBCL) and GOASSESS, based on semantic content. We estimated bifactor models using confirmatory factor analysis, and calculated their model fit, factor reliability, between‐instrument invariance, and authenticity (i.e., the correlation and factor score difference between the harmonized and original models). Results: Five out of 12 model configurations presented acceptable fit and were instrument‐invariant. Correlations between the harmonized factor scores and the original full‐item models were high for the p‐factor (>0.89) and small to moderate (0.12–0.81) for the specific factors. 6.3%–50.9% of participants presented factor score differences between harmonized and original models higher than 0.5 z‐score. Conclusions: The CBCL‐GOASSESS harmonization indicates that few models provide reliable specific factors and are instrument‐invariant. Moreover, authenticity was high for the p‐factor and moderate for specific factors. Future studies can use this framework to examine the impact of harmonizing instruments in psychiatric research. [ABSTRACT FROM AUTHOR]
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- 2023
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31. Polygenic risk score for attention‐deficit/hyperactivity disorder and brain functional networks segregation in a community‐based sample
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Sato, João Ricardo, primary, Biazoli, Claudinei Eduardo, additional, Bueno, Ana Paula Arantes, additional, Caye, Arthur, additional, Pan, Pedro Mario, additional, Santoro, Marcos, additional, Honorato‐Mauer, Jessica, additional, Salum, Giovanni Abrahão, additional, Hoexter, Marcelo Queiroz, additional, Bressan, Rodrigo Affonseca, additional, Jackowski, Andrea Parolin, additional, Miguel, Euripedes Constantino, additional, Belangero, Sintia, additional, and Rohde, Luis Augusto, additional
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- 2023
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32. Assessing atypical brain functional connectivity development: An approach based on generative adversarial networks
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Dos Santos, Pedro Machado Nery, primary, Mendes, Sérgio Leonardo, additional, Biazoli, Claudinei, additional, Gadelha, Ary, additional, Salum, Giovanni Abrahão, additional, Miguel, Euripedes Constantino, additional, Rohde, Luis Augusto, additional, and Sato, João Ricardo, additional
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- 2023
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33. Translating measurement into practice: Brazilian norms for the Patient Health Questionnaire (PHQ-9) for assessing depressive symptoms
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Damiano, Rodolfo Furlan, primary, Hoffmann, Maurício Scopel, additional, Gosmann, Natan Pereira, additional, Pan, Pedro Mario, additional, Miguel, Eurípedes Constantino, additional, and Salum, Giovanni Abrahão, additional
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- 2023
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34. Statistical and functional convergence of common and rare genetic influences on autism at chromosome 16p
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Weiner, Daniel J., Ling, Emi, Erdin, Serkan, Tai, Derek J. C., Yadav, Rachita, Grove, Jakob, Fu, Jack M., Nadig, Ajay, Carey, Caitlin E., Baya, Nikolas, Bybjerg-Grauholm, Jonas, Mortensen, Preben B., Werge, Thomas, Demontis, Ditte, Mors, Ole, Nordentoft, Merete, Als, Thomas D., Baekvad-Hansen, Marie, Rosengren, Anders, Havdahl, Alexandra, Hedemand, Anne, Palotie, Aarno, Chakravarti, Aravinda, Arking, Dan, Sulovari, Arvis, Starnawska, Anna, Thiruvahindrapuram, Bhooma, de Leeuw, Christiaan, Carey, Caitlin, Ladd-Acosta, Christine, van der Merwe, Celia, Devlin, Bernie, Cook, Edwin H., Eichler, Evan, Corfield, Elisabeth, Dieleman, Gwen, Schellenberg, Gerard, Hakonarson, Hakon, Coon, Hilary, Dziobek, Isabel, Vorstman, Jacob, Girault, Jessica, Sutcliffe, James S., Duan, Jinjie, Nurnberger, John, Hallmayer, Joachim, Buxbaum, Joseph, Piven, Joseph, Weiss, Lauren, Davis, Lea, Janecka, Magdalena, Mattheisen, Manuel, State, Matthew W., Gill, Michael, Daly, Mark, Uddin, Mohammed, Andreassen, Ole, Szatmari, Peter, Lee, Phil Hyoun, Anney, Richard, Ripke, Stephan, Satterstrom, Kyle, Santangelo, Susan, Kuo, Susan, van Elst, Ludger Tebartz, Rolland, Thomas, Bougeron, Thomas, Polderman, Tinca, Turner, Tychele, Underwood, Jack, Manikandan, Veera, Pillalamarri, Vamsee, Warrier, Varun, Philipsen, Alexandra, Reif, Andreas, Hinney, Anke, Cormand, Bru, Bau, Claiton H. D., Rovaris, Diego Luiz, Sonuga-Barke, Edmund, Corfield, Elizabeth, Grevet, Eugenio Horacio, Salum, Giovanni, Larsson, Henrik, Buitelaar, Jan, Haavik, Jan, McGough, James, Kuntsi, Jonna, Elia, Josephine, Lesch, Klaus-Peter, Klein, Marieke, Bellgrove, Mark, Tesli, Martin, Leung, Patrick W. L., Pan, Pedro M., Dalsgaard, Soren, Loo, Sandra, Medland, Sarah, Faraone, Stephen V., Reichborn-Kjennerud, Ted, Banaschewski, Tobias, Hawi, Ziarih, Berretta, Sabina, Macosko, Evan Z., Sebat, Jonathan, O’Connor, Luke J., Hougaard, David M., Børglum, Anders D., Talkowski, Michael E., McCarroll, Steven A., Robinson, Elise B., Pediatrics, Amsterdam Neuroscience - Complex Trait Genetics, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, Hinney, Anke (Beitragende*r), Child and Adolescent Psychiatry / Psychology, Centre of Excellence in Complex Disease Genetics, Research Programs Unit, Aarno Palotie / Principal Investigator, Institute for Molecular Medicine Finland, Genomics of Neurological and Neuropsychiatric Disorders, Complex Trait Genetics, and Clinical Developmental Psychology
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Genètica humana ,DNA Copy Number Variations ,Autism ,3112 Neurosciences ,Medizin ,Chromosomes ,Cromosomes ,Human genetics ,Genetics ,Humans ,Autistic Disorder ,Chromosome Deletion ,Chromosomes, Human, Pair 16/genetics ,Autisme ,Chromosomes, Human, Pair 16 ,Autistic Disorder/genetics - Abstract
in press, weitere Verfasser:innen aus Einrichtungen außerhalb der Universität Duisburg-Essen sind nicht aufgeführt. The canonical paradigm for converting genetic association to mechanism involves iteratively mapping individual associations to the proximal genes through which they act. In contrast, in the present study we demonstrate the feasibility of extracting biological insights from a very large region of the genome and leverage this strategy to study the genetic influences on autism. Using a new statistical approach, we identified the 33-Mb p-arm of chromosome 16 (16p) as harboring the greatest excess of autism’s common polygenic influences. The region also includes the mechanistically cryptic and autism-associated 16p11.2 copy number variant. Analysis of RNA-sequencing data revealed that both the common polygenic influences within 16p and the 16p11.2 deletion were associated with decreased average gene expression across 16p. The transcriptional effects of the rare deletion and diffuse common variation were correlated at the level of individual genes and analysis of Hi-C data revealed patterns of chromatin contact that may explain this transcriptional convergence. These results reflect a new approach for extracting biological insight from genetic association data and suggest convergence of common and rare genetic influences on autism at 16p.
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- 2022
35. Is the 9-item Patient Health Questionnaire sufficiently sensitive to detect clinical risk of suicide in essential workers seeking emotional support during the COVID-19 pandemic?
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Motta, Luis Souza, Costa, Marianna de Abreu, Spanemberg, Lucas, Dreher, Carolina Blaya, and Salum, Giovanni Abrahão
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- 2022
36. Utilisation and costs of mental health-related service use among adolescents
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Ziebold, Carolina, primary, Silva-Ribeiro, Wagner, additional, King, Derek, additional, McDaid, David, additional, Hoffmann, Mauricio Scopel, additional, Romeo, Renee, additional, Pan, Pedro Mario, additional, Miguel, Eurípedes Constantino, additional, Bressan, Rodrigo Affonseca, additional, Rohde, Luis Augusto, additional, Salum, Giovanni Abrahão, additional, Mari, Jair de Jesus, additional, and Evans-Lacko, Sara, additional
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- 2022
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37. Associations between child disciplinary practices and bullying behavior in adolescents
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Zottis, Graziela A.H., Salum, Giovanni A., Isolan, Luciano R., Manfro, Gisele G., and Heldt, Elizeth
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- 2014
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38. Psychometric properties of the dimensional anxiety scales for DSM‐5 in a Brazilian community sample
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DeSousa, Diogo A., Moreno, André L., Osório, Flávia L., Crippa, José Alexandre S., LeBeau, Richard, Manfro, Gisele G., Salum, Giovanni A., and Koller, Silvia H.
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- 2017
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39. DNA methylation in adolescents with anxiety disorder: a longitudinal study
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Bortoluzzi, Andressa, Salum, Giovanni Abrahão, da Rosa, Eduarda Dias, Chagas, Vinicius de Saraiva, Castro, Mauro Antônio Alves, and Manfro, Gisele Gus
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- 2018
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40. Disentangling the influences of parental genetics on offspring's cognition, education, and psychopathology via genetic and phenotypic pathways
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Axelrud, Luiza, Hoffmann, Mauricio, Vosberg, Daniel, Santoro, Marcos, Pan, Pedro, Gadelha, Ary, Belangero, Sinita, Euripedes, Miguel, Shin, Jean, Thapar, Anita, Smoller, Jordan, Pausova, Zdenka, Rohde, Luis, Keller, Matthew, Paus, Tomas, and Salum, Giovanni
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- 2022
41. Structural brain correlates of childhood inhibited temperament:An ENIGMA-anxiety mega-analysis
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Bas-Hoogendam, Janna Marie, Bernstein, Rachel, Benson, Brenda E., Buss, Kristin A., Gunther, Kelley E., Pérez-Edgar, Koraly, Salum, Giovanni A., Jackowski, Andrea P., Bressan, Rodrigo A., Zugman, André, Degnan, Kathryn A., Filippi, Courtney A., Fox, Nathan A., Henderson, Heather A., Tang, Alva, Zeytinoglu, Selin, Harrewijn, Anita, Hillegers, Manon H.J., White, Tonya, van IJzendoorn, Marinus H., Schwartz, Carl E., Felicione, Julia M., DeYoung, Kathryn A., Shackman, Alexander J., Smith, Jason F., Tillman, Rachael M., van den Berg, Yvonne H.M., Cillessen, Antonius H.N., Roelofs, Karin, Tyborowska, Anna, Hill, Shirley Y., Battaglia, Marco, Tettamanti, Marco, Dougherty, Lea R., Jin, Jingwen, Klein, Daniel N., Leung, Hoi Chung, Avery, Suzanne N., Blackford, Jennifer Urbano, Clauss, Jacqueline A., Hayden, Elizabeth P., Liu, Pan, Vandermeer, Matthew R.J., Goldsmith, H. Hill, Planalp, Elizabeth M., Nichols, Thomas E., Thompson, Paul M., Westenberg, P. Michiel, van der Wee, Nic J.A., Groenewold, Nynke A., Bas-Hoogendam, Janna Marie, Bernstein, Rachel, Benson, Brenda E., Buss, Kristin A., Gunther, Kelley E., Pérez-Edgar, Koraly, Salum, Giovanni A., Jackowski, Andrea P., Bressan, Rodrigo A., Zugman, André, Degnan, Kathryn A., Filippi, Courtney A., Fox, Nathan A., Henderson, Heather A., Tang, Alva, Zeytinoglu, Selin, Harrewijn, Anita, Hillegers, Manon H.J., White, Tonya, van IJzendoorn, Marinus H., Schwartz, Carl E., Felicione, Julia M., DeYoung, Kathryn A., Shackman, Alexander J., Smith, Jason F., Tillman, Rachael M., van den Berg, Yvonne H.M., Cillessen, Antonius H.N., Roelofs, Karin, Tyborowska, Anna, Hill, Shirley Y., Battaglia, Marco, Tettamanti, Marco, Dougherty, Lea R., Jin, Jingwen, Klein, Daniel N., Leung, Hoi Chung, Avery, Suzanne N., Blackford, Jennifer Urbano, Clauss, Jacqueline A., Hayden, Elizabeth P., Liu, Pan, Vandermeer, Matthew R.J., Goldsmith, H. Hill, Planalp, Elizabeth M., Nichols, Thomas E., Thompson, Paul M., Westenberg, P. Michiel, van der Wee, Nic J.A., and Groenewold, Nynke A.
- Published
- 2022
42. Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-analysis
- Author
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Bas-Hoogendam, J, Bernstein, R, Benson, B, Buss, K, Gunther, K, Pérez-Edgar, K, Salum, G, Jackowski, A, Bressan, R, Zugman, A, Degnan, K, Filippi, C, Fox, N, Henderson, H, Tang, A, Zeytinoglu, S, Harrewijn, A, Hillegers, M, White, T, van IJzendoorn, M, Schwartz, C, Felicione, J, Deyoung, K, Shackman, A, Smith, J, Tillman, R, van den Berg, Y, Cillessen, A, Roelofs, K, Tyborowska, A, Hill, S, Battaglia, M, Tettamanti, M, Dougherty, L, Jin, J, Klein, D, Leung, H, Avery, S, Blackford, J, Clauss, J, Hayden, E, Liu, P, Vandermeer, M, Goldsmith, H, Planalp, E, Nichols, T, Thompson, P, Westenberg, P, van der Wee, N, Groenewold, N, Stein, D, Winkler, A, Pine, D, Bas-Hoogendam, Janna Marie, Bernstein, Rachel A., Benson, Brenda E., Buss, Kristin A., Gunther, Kelley E., Pérez-Edgar, Koraly, Salum, Giovanni A., Jackowski, Andrea, Bressan, Rodrigo A., Zugman, André, Degnan, Kathryn A., Filippi, Courtney A., Fox, Nathan A., Henderson, Heather A., Tang, Alva, Zeytinoglu, Selin, Harrewijn, Anita, Hillegers, Manon H. J., White, Tonya, van IJzendoorn, Marinus H., Schwartz, Carl E., Felicione, Julia M., DeYoung, Kathryn A., Shackman, Alexander J., Smith, Jason F., Tillman, Rachael, van den Berg, Yvonne H. M., Cillessen, Antonius H. N., Roelofs, Karin, Tyborowska, Anna, Hill, Shirley Y., Battaglia, Marco, Tettamanti, Marco, Dougherty, Lea R., Jin, Jingwen, Klein, Daniel N., Leung, Hoi-Chung, Avery, Suzanne N., Blackford, Jennifer Urbano, Clauss, Jacqueline A., Hayden, Elizabeth P., Liu, Pan, Vandermeer, Matthew R. J., Goldsmith, H. Hill, Planalp, Elizabeth M., Nichols, Thomas E., Thompson, Paul M., Westenberg, P. Michiel, van der Wee, Nic J. A., Groenewold, Nynke A., Stein, Dan J., Winkler, Anderson M., Pine, Daniel S., Bas-Hoogendam, J, Bernstein, R, Benson, B, Buss, K, Gunther, K, Pérez-Edgar, K, Salum, G, Jackowski, A, Bressan, R, Zugman, A, Degnan, K, Filippi, C, Fox, N, Henderson, H, Tang, A, Zeytinoglu, S, Harrewijn, A, Hillegers, M, White, T, van IJzendoorn, M, Schwartz, C, Felicione, J, Deyoung, K, Shackman, A, Smith, J, Tillman, R, van den Berg, Y, Cillessen, A, Roelofs, K, Tyborowska, A, Hill, S, Battaglia, M, Tettamanti, M, Dougherty, L, Jin, J, Klein, D, Leung, H, Avery, S, Blackford, J, Clauss, J, Hayden, E, Liu, P, Vandermeer, M, Goldsmith, H, Planalp, E, Nichols, T, Thompson, P, Westenberg, P, van der Wee, N, Groenewold, N, Stein, D, Winkler, A, Pine, D, Bas-Hoogendam, Janna Marie, Bernstein, Rachel A., Benson, Brenda E., Buss, Kristin A., Gunther, Kelley E., Pérez-Edgar, Koraly, Salum, Giovanni A., Jackowski, Andrea, Bressan, Rodrigo A., Zugman, André, Degnan, Kathryn A., Filippi, Courtney A., Fox, Nathan A., Henderson, Heather A., Tang, Alva, Zeytinoglu, Selin, Harrewijn, Anita, Hillegers, Manon H. J., White, Tonya, van IJzendoorn, Marinus H., Schwartz, Carl E., Felicione, Julia M., DeYoung, Kathryn A., Shackman, Alexander J., Smith, Jason F., Tillman, Rachael, van den Berg, Yvonne H. M., Cillessen, Antonius H. N., Roelofs, Karin, Tyborowska, Anna, Hill, Shirley Y., Battaglia, Marco, Tettamanti, Marco, Dougherty, Lea R., Jin, Jingwen, Klein, Daniel N., Leung, Hoi-Chung, Avery, Suzanne N., Blackford, Jennifer Urbano, Clauss, Jacqueline A., Hayden, Elizabeth P., Liu, Pan, Vandermeer, Matthew R. J., Goldsmith, H. Hill, Planalp, Elizabeth M., Nichols, Thomas E., Thompson, Paul M., Westenberg, P. Michiel, van der Wee, Nic J. A., Groenewold, Nynke A., Stein, Dan J., Winkler, Anderson M., and Pine, Daniel S.
- Published
- 2022
43. Thrifty-Eating Behavior Phenotype at the Food Court – Programming Goes Beyond Food Preferences
- Author
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Dalle Molle, Roberta, primary, de Mendonça Filho, Euclides José, additional, Minuzzi, Luciano, additional, Machado, Tania Diniz, additional, Reis, Roberta Sena, additional, Rodrigues, Danitsa Marcos, additional, Mucellini, Amanda Brondani, additional, Franco, Alexandre Rosa, additional, Buchweitz, Augusto, additional, Toazza, Rudineia, additional, Bortoluzzi, Andressa, additional, Salum, Giovanni Abrahão, additional, Boscenco, Sonia, additional, Meaney, Michael J., additional, Levitan, Robert D., additional, Manfro, Gisele Gus, additional, and Silveira, Patricia Pelufo, additional
- Published
- 2022
- Full Text
- View/download PDF
44. Implementation of Group Interpersonal Psychotherapy in primary care
- Author
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Mattos, Maria Isabel Perez, primary, Mosqueiro, Bruno Paz, additional, Stuart, Scott, additional, Salum, Giovanni, additional, Duzzo, Rosana de Lima, additional, Souza, Laura Wolf de, additional, Chini, Ariane, additional, and Fleck, Marcelo Pio de Almeida, additional
- Published
- 2022
- Full Text
- View/download PDF
45. Predictors of gaming disorder in Brazilian children and adolescents: a school-based study
- Author
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Ferreira, Felipe de M., Bambini, Beatriz B., Tonsig, Gabriela K., Fonseca, Lais, Picon, Felipe A., Pan, Pedro M., Salum, Giovanni A., Jackowski, Andrea, Miguel, Eurípedes C., Rohde, Luis A., Bressan, Rodrigo A., and Gadelha, Ary
- Subjects
game genres ,Internet ,Schools ,Adolescent ,Gaming disorder ,online games ,Brief Communication ,mental disorders ,Behavior, Addictive ,Disruptive, Impulse Control, and Conduct Disorders ,predictors ,Video Games ,Humans ,Child ,human activities ,Brazil ,gaming session - Abstract
Objective: To determine whether psychiatric and gaming pattern variables are associated with gaming disorder in a school-based sample. Methods: We analyzed data from the Brazilian High-Risk Cohort for Psychiatric Disorders, a community sample aged 10 to 18, using questionnaires on gaming use patterns. We applied the Gaming Addiction Scale to diagnose gaming disorder and the Development and Well-Being Behavior Assessment for other diagnoses. Results: Out of 407 subjects, 83 (20.4%) fulfilled the criteria for gaming disorder. More role-playing game players were diagnosed with gaming disorder that any other genre. Gaming disorder rates increased proportionally to the number of genres played. Playing online, being diagnosed with a mental disorder, and more hours of non-stop gaming were associated with higher rates of gaming disorder. When all variables (including age and gender) were considered in a logistic regression model, the number of genres played, the number of non-stop hours, the proportion of online games, and having a diagnosed mental disorder emerged as significant predictors of gaming disorder. Conclusion: Each variable seems to add further risk of gaming disorder among children and adolescents. Monitoring the length of gaming sessions, the number and type of genres played, time spent gaming online, and behavior changes may help parents or guardians identify unhealthy patterns of gaming behavior.
- Published
- 2020
46. Screen time and psychopathology. [Carta]: investigating directionality using cross-lagged panel models
- Author
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Salum, Giovanni A
- Subjects
ADOLESCENTES - Published
- 2022
47. Mental health conditions in lesbian, gay, bisexual, transgender, queer and asexual youth in Brazil: a call for action
- Author
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Salum, Giovanni A
- Subjects
BRASIL - Published
- 2022
48. General Psychopathology, Cognition, and the Cerebral Cortex in 10-Year-Old Children: Insights From the Adolescent Brain Cognitive Development Study
- Author
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Patel, Yash, primary, Parker, Nadine, additional, Salum, Giovanni A., additional, Pausova, Zdenka, additional, and Paus, Tomáš, additional
- Published
- 2022
- Full Text
- View/download PDF
49. Youth mental health services: the right time for a global reach
- Author
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Kieling, Christian, primary, Salum, Giovanni A., additional, Pan, Pedro M., additional, and Bressan, Rodrigo A., additional
- Published
- 2022
- Full Text
- View/download PDF
50. Is the PHQ-9 item of suicide thoughts good enough to detect clinical risk of suicide in workers from essential services seeking emotional support during the COVID-19 pandemic?
- Author
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Motta, Luis Souza, primary, Costa, Marianna de Abreu, additional, Spanemberg, Lucas, additional, Dreher, Carolina Blaya, additional, and Salum, Giovanni Abrahão, additional
- Published
- 2022
- Full Text
- View/download PDF
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