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The article is devoted to the study of the problems of the training of physical therapists associated with the formation in students of a sufficient amount of knowledge and skills in etiology, diagnosis of deviations in the health of patients with disorders of the cardiovascular system, means and methods of physical therapy. The revealed topics are presented in the program of training students in the methods and technologies of working as a physical therapist with clients who have diseases of the cardiovascular system. As a result of studying the discipline, the student should know: basic concepts of general nosology; the role of factors, conditions and reactivity of the body in the occurrence, development and termination of diseases of the cardiovascular system; causes and mechanisms of diseases of the cardiovascular system, their manifestations and prognosis for the body during their development; etiology, pathogenesis, manifestations and consequences of the most frequent diseases of the cardiovascular system, principles of their etiological and pathogenetic therapy; – the value of the experimental method (modeling of diseases and painful states) in the study of diseases of the cardiovascular system; its possibilities, limitations and prospects. The student should be able to: – analyze clinical and laboratory, experimental and other data and formulate possible causes and mechanisms of development of diseases of the cardiovascular system based on them; apply the acquired knowledge when studying other clinical disciplines in further treatment and prevention activities; to analyze the problems of diseases of the cardiovascular system from the point of view of critical assessment of modern theoretical concepts and trends in medicine; to interpret the results of the most common methods of diagnosing diseases of the cardiovascular system; solve situational problems; skillfully conduct system surveys and collect history; to be able to conduct a physical examination, knowing the techniques of palpation, percussion and auscultation; by the nature of the temperature curve, determine the type of fever in inflammatory diseases of the cardiovascular system; interpret the results of basic diagnostic allergy tests; substantiate the principles of pathogenetic therapy of the most common diseases of the cardiovascular The content of the lecture material is revealed. The results of the survey of 38 students on 12 questions are presented. 100% of the surveyed students connected this discipline with the general field of study and felt the need to study it for their future work in the field. The material offered to students contributes to their preparation for work as a physical therapist with clients who have diseases of the cardiovascular system.

The leading method of physical therapy for children with Goldenhar syndrome is the specialization of socialization and communication skills. Goldehar's syndrome is genetically heterogeneous, develops spontaneously and is characterized by underdevelopment of the auricles, deformation and abnormal location, macrostomia, anomalies of the palate, interspinal tongue, and additional frenulums. Tasks of physical therapy: increasing the working capacity of the body, with the help of efforts with normal tolerance to fatigue, development of willpower (perseverance, determination, endurance, etc.); fixing the correct reactions to kinetic, visual, verbal stimuli. The performance of these exercises facilitates initially simple, and over time complex verbal instructions, they may not be supported by the demonstration of movements; to encourage the release of the activity of motor movements, so that they have a meaningful character, motor qualities, and the development of motor functions in the child. All this is aimed at the orderliness of the child's activity, which becomes purposeful, and the behavior is more disciplined; increasing the level of concentration: learning the ability to listen, consider, and perform clear, understandable actions; harmonization of the emotional component, formation of communication skills between adults and the child, precisely because of this, the restlessness and aggression that may arise in the child is removed; encouraging interest in communication, developing collectivism, learning to work in a team, promoting interpersonal interactions in a group. The construction of the process of learning communication and motor actions is determined by the laws of the formation of motor skills and takes place over a certain period. To form this, interaction with the world and physical development are required. Therefore, the formation of these skills is important for determining the directions of the child's integration in society. The use of an improved complex program of physical therapy made it possible to form some new communication stereotypes, which gave children the opportunity to perform new motor actions at a new level of motor functions, combining them with communication skills. This made it possible to increase the quality of children's socialization. The conducted studies show that the improvement of existing physical therapy programs can ensure the achievement of the maximum possible positive result and improvement of the general social and communication status of a child with the orphan disease Goldenhar syndrome.

The article presents myofunctional therapy in young children with special needs. The literature is analyzed and it is shown that this problem is quite rare. It is shown that the influence of anomalies in the structure and functions of the dental system on the formation and development of the musculoskeletal system of the maxillofacial region and the speech-communication mechanism in children). The reasons for the appearance of myofunctional disorders in children are presented. The causes of myofunctional disorders are: dysfunction; bad habits; genetic predisposition. Indications for the correction of disorders of muscle tone of masticatory and facial muscles have been established. Groups of manifestations of myofunctional disorders in children of primary school age are characterized. The following groups of manifestations of myofunctional disorders have been identified: group I – myofunctional disorders caused by biological determinants; group II – myofunctional disorders caused by social determinants; group III – myofunctional disorders caused by biosocial determinants. Systems of work on correction of disorders in children are presented. A comparative quantitative and qualitative analysis of the positive dynamics in overcoming the manifestations of disorders of facial expressions, oral, articulatory praxis and physiological speech breathing is given. The system of work on the correction of myofunctional disorders in children of primary school age with special educational needs. It is proved that the complex application of kinesiotaping, orofacial and articulation massage, myogymnastics and long-term wearing of special trainers in the complex rehabilitation of myofunctional disorders in primary school children with special educational needs helped regulate the tone of facial expressions, chewing gum, and strength; reduction of hypersalivation; normalization of mobility of jaw joints, lower jaw, larynx; partial qualitative improvement of chewing and swallowing processes; reduce swelling and congestion in the muscles.

The prolongation of survival and the improvement of quality of life in patients with hemophilia A and B are only possible if hemostatic disorders caused by coagulation factor VIII and IX deficiency are managed effectively. Recombinant coagulation factors are playing an ever-increasing role in the preventive care of affected patients. The development, production and use of domestic recombinant coagulation factors opened up new treatment opportunities and improved access to preventive care for hemophilia patients. The results of clinical studies on the efficacy and safety of the Russian recombinant factors showed that they had similar efficacy and safety compared to the plasma derived clotting factors.

A thermodynamic model has been formulated for the formation work of a molecular aggregate consisting of molecules of a nonionic surfactant and a solubilisate in a hydrocarbon–surfactant–water solution as a function of temperature, concentrations of the surfactant and hydrocarbon in the solution, and aggregation numbers of the surfactant and hydrocarbon in the aggregate. The model depends on the structural parameters and physical characteristics of surfactant and solubilisate molecules. Predictions of the model concerning the minimum and the saddle point of the aggregation work have been considered and the distributions of relative concentrations of aggregates over the aggregation numbers of the surfactant and solubilisate have been plotted at different concentrations of surfactant and hydrocarbon monomers in the solution. The fractions of the surfactant and solubilisate in the aggregates have been numerically estimated relative to the equilibrium concentrations of surfactant and solubilisate monomers, and the average aggregation numbers of the surfactant and solubilisate in the aggregates have been found. The possibility of the colossal accumulation of solubilisate molecules in the molecular aggregates has been shown. The aggregation and solubilization have been considered at equilibrium surfactant concentrations that are markedly lower than the critical micelle concentration in a pure surfactant solution. It has been found that the limiting concentrations of the nonionic surfactant and the solubilisate corresponding to the formation of stable nanoemulsions lie in rather narrow ranges, and it is unlikely to get into them as a result of the random search in laboratory experiments.

All-atom molecular dynamics has been employed to study the processes of self-aggregation and solubilization in aqueous solutions that contain decane, ionic and nonionic surfactants, and additives of salts. In particular, micellization of an anionic surfactant (sodium dodecyl sulfate) in an aqueous solution has been simulated in the presence of a hydrocarbon (decane) at preset temperature and pressure and different initial surfactant and hydrocarbon concentrations in the solution. Moreover, self-aggregation has been simulated in systems containing water, decane, and a mixture of anionic (sodium dodecyl sulfate) and nonionic (hexaethylene glycol monodecyl ether, C10E6) both in a salt-free solution and in the presence of sodium chloride, calcium chloride, or a mixture thereof. Diffusion coefficients have been calculated for aggregates consisting of hydrocarbon and surfactant aggregates, and the viscosities of corresponding aqueous solutions have been estimated. The viscosities have been calculated in simulation cells containing either one or several aggregates.

The article is devoted to the study of the influence of the development of innovations on the economic security of the regions. Based on the assumption that innovative development plays a key role in the process of ensuring the economic security of the region, the authors proposed a system of indicators for assessing the innovative component of the economic security of the region, including the indicators of economic security reflected in the Decree «On the Strategy of Economic Security of the Russian Federation for the Period up to 2030». The impact of innovations is realized through the achievement of the goals of ensuring the country's security, among which is the dynamic and progressive development of the economy. The authors proposed a methodology for assessing the innovative component of economic security based on the scoring method, developed an assessment scale for interpreting the results of calculations, assessed the innovative security of regional economic systems of the Federal Districts of Russia for the period 2015–2019. As a result of the analysis, factors were identified that hinder innovative development and negatively affect the provision of economic security at the regional level: underdevelopment, low efficiency of the innovation infrastructure, reduction of internal costs for research and development, a decrease in the number of developed advanced production technologies, and others. It has been established that the economic security of a region depends on its ability to perceive innovations, while institutional factors have a significant impact on the pace of development. The work has improved the methodological tools for diagnosing the innovative security of the regions of the Russian Federation by optimizing the system of criteria for its assessment. The results of the empirical studies carried out confirmed the possibility of practical use of the developed methodology for diagnosing the innovative security of the regions of the Russian Federation and identifying priority areas for its improvement.

The expansion of viticulture in the world is accompanied by the spread of diseases and plant pests. Phylloxera is one of those organisms causing enormous damage to the world’s viticulture. The discovery of the possibility of grafting varieties on stock has led to the development of the breeding of stock originating from North America. Currently, the active use of different types of molecular markers for the identification and study of the genetic diversity of grapes allows to more accurately and efficiently study the biological peculiarities and genetics of plants. Obtaining good reproducibility of the analysis results and revealing the polymorphism between varieties and clones when using different types of markers, you can further use this knowledge for breeding in the selection of crossed pairs. The aim of the study in the present article was to study the common stock grape varieties - hybrids of American species. The article presents a study of the five most famous stock grape varieties: Kober 5BB and 420-A, Paulsen 1103, 101-14 and Richter 57 to identify genetic relationships and polymorphism between samples, based on the use of IRAP and iPBS primers. We used thirteen selected DNA markers that generated a total of 308 polymorphic DNA bands with 54.95 % polymorphism. The effectiveness of iPBS markers was comparable or even more effective than the markers based on retrotransposons. As a result of research, differences and commonality between stocks were clearly demonstrated by both cluster analysis and PCoA analysis.

Сьогодні Україна займає дев’яте місце у світі за кількістю внутрішньо переміщених осіб (ВПО). Масштабні вимушені внутрішні міграції останніх років не могли не відобразитися на стані здоров’я як певної соціальної групи, так і на стані здоров’я населення у цілому. Мета – вивчення факторів психічної травматизації, їх динаміки у часі та впливу на стан психічного здоров’я, визначення стресостійкості та соціальної адаптації у ВПО. Матеріал і методи. Методи обстеження включали клініко-психопатологічний з оцінкою факторів психічної травматизації, методику визначення стресостійкості та соціальної адаптації Т. Холмса і Р. Раге для оцінки актуального рівня стресу протягом останнього року, статистичні методи. Дослідження проведено в ДУ «Інститут неврології, психіатрії та наркології НАМН України» у відділі пограничної психіатрії. Всього було обстежено 213 ВПО. Усі обстежені були поділені на 3 групи: до І групи увійшли 94 ВПО із загальної популяції, у яких не було виявлено психічних розладів (умовно здорові); 68 осіб, у яких були визначені окремі психічні симптоми, що не сягали клінічного рівня, склали ІІ групу (група ризику) та 51 особа, що звернулася за медичною допомогою та мала діагностовані психічні розлади, увійшли до ІІІ групи (обстежені з психічними розладами). Результати. Всім обстеженим була проведена оцінка стресогенних факторів (СФ), що включали фізіологічні, психоемоційні, соціально-психологічні та інформаційні чинники та відображала їх динаміку в часі. Рівень опірності стресу відрізнявся у здорових, хворих та осіб з групи ризику. Висновки. Загальна оцінка впливу стресогенних чинників на ВПО свідчить про їх поєднану дію, різний ступінь патогенності та динаміки у часі.

This article is devoted to one of the main problems in marketing - development of marketing strategy for e-commerce in modern competitive conditions. The article deals with different methods of using marketing schemes, the main methods of information distribution and attracting new customers.

The article examines the issues of risk assessment for reducing the financial stability of the enterprise. The content of the risk of financial stability is considered and the main approaches to its analysis are determined. The study revealed that the most common is the traditional approach. In the framework of this approach, key areas for analyzing the financial stability of an organization are defined and their meaningful characteristics are given. The results of the calculation and analysis of the risk of a decrease in financial stability depend on the presence/absence of distortions in the financial statements. Based on the conducted research, the organization's operations were identified, which can lead to a deterioration in the structure of the balance sheet and a decrease in financial stability. It is noted that the forecasting of financial difficulties will allow timely reacting to changes and developing adequate measures to reduce financial risks. The risk of reducing financial sustainability is multifaceted, and there is a high correlation between risk factors. In this regard, it seems appropriate to talk about the advisability of using a risk-oriented approach in the practice of financial stability management. This approach will solve the problem of ineffective management and non-compliance with legislation in the process of reflecting the facts of economic life, which will improve the quality of analysis of the financial situation of the enterprise. The proposed algorithm for managing the risk of reducing financial stability will make it possible to draw up a plan of action to minimize adverse impacts. In conclusion, it was concluded that sustainable development and stable status of economic entities in modern conditions is determined by their ability to respond in a timely manner to changing conditions of the functioning environment, which reflects the indicators of financial stability. Therefore, the necessary condition for the effective operation of the organization is its financial sustainability.

Periodic disease or Familial Mediterranean fever is an inherited monogenic disease widespread among the ancient peoples of the countries of Mediterranean region: Armenians, Jews, Turks, Arabs. MEFV gene (Familian Mediterranean Fever Gene) located on chromosome 16 in the region 16р13.3, is responsible for the development of the disease. MEFV gene encodes marenostrin protein (Pirin) involved in the regulation of inflammatory processes. Typical manifestations of the disease are recurrent fever, peritonitis, synovitis, pleuritis, and rarely pericarditis, meningitis, erysipeloid skin lesions, development of amyloidosis, mainly kidneys, is also characteristic. In the described clinical case the disease has manifested as recurrent interstitial lung disease and morphea-like skin lesion. Over 5 years the lung pathology was considered as cryptogenic organizing pneumonia, so the patient was administered corticosteroids (with no effect). In 2013, molecular genetic study detected mutations V726A and A744S in compaud-heterozygous state, the diagnosis of periodic disease was confirmed. Receiving colchicine for over 3.5 years induced remission of the disease: there were no episodes of febrile fever and exacerbations of pneumonia, radiologic regression of lung lesions and elimination of morphea-like skin lesion was observed. Clinical symptoms of periodic disease in this case are rarely encountered.

Purpose. Determination of efficiency and tolerance of Sotret product in treatment of patients with different clinical forms and severe acne in three clinical investigations. Materials and methods. 103 patients with acne (moderate and severe acne, acne conglobata and acne inversa) were examined and treated. All patients underwent monotherapy with Sotret with clinical effectiveness assessment and records of adverse events. Results. Sotret therapy facilitated clinical remission of acne in 90-100% of cases. Adverse events were easily tolerated and were not serious. Conclusion. Established therapeutic efficiency of Sotret determines its potential in treating various severity and various forms of acne.

The role of symbols in art and computer graphics for correct plot understanding, when viewing works of art in an electronic library is considered. Special emphasis is placed on mathematical symbols, revealing abstraction beauty side in mathematics and its penetration into artistic images and the spots created by the artists. Due to computer database artist's original intention can be decoded . Based on the semantic meanings of mathematical symbols they are considered to be fundamental pillars in the art of computer graphics: the Universe, the spiritual human development, continuity and discretion, the truth in the search of solving universe problems. Human's willness to develop space implies constructive activities for peaceful purposes when developing new technologies. Analyzing the development of spatial layers by life, we conclude that the emergence of the social and ecological system is aimed to develop new tiers in evolution development, but no to remake developed lower tiers of the existing flora and fauna, and not to achieve world domination. Nature expected the appearance of a mankind for constructive activitiesties in the space exploration. This is evidenced by the activities of Tsiolkovsky, Korolev, Gagarin. Instead of developing new living spaces and living peacefully with all representatives of flora and fauna, mankind conflics destroying everything around including Itself. The notions 'chance', 'luck' acquire visial representation thanks to computer graphics in accordance with the edu-cational standards indicating certain amount of academic hours given to mathematics, including modeling, and the-oretical-probabilistic methods of research, processing of experimental results.

Environmental impact assessment (EIA) in planning any economic activity is an important point not only for its resolution, but also for the preservation or replenishment of biological objects of nature. Scientists of the Federal State Budgetary Scientific Institution “Krasnodar Research Centre for Animal Husbandry and Veterinary Medicine” have developed a simplified electronic template for calculating the amount of damage to aquatic biological resources when planning the economic activities of enterprises in the immediate vicinity of water bodies. It allows you to determine the harm from the implementation of economic and other activities, as well as calculate the amount of damage to aquatic biological resources from its conduct, including their habitat.

Legal documents that provide laboratory diagnosis of syphilis in the Russian Federation, have been published for more than 10 years and does not fully correspond to the current state of syphilis and its level of diagnostic methods. At the same, the existing orders and guidelines emphasizes the need based on the specific situation with the incidence of sexually transmitted infections, systematically review the “at risk” population to be screened. Treatment-and-prophylactic institutions of the Moscow Department of health done by step work on the transition to modern diagnostic tests for diagnosis of syphilis. Currently, the available equipment and trained personnel can replace the use of a complex of serological tests on the reaction of passive hemagglutination and enzyme immunoassay.

The article presents the results of a survey of patients of dermatovenerological institutions of Moscow. Analyzes their views on syphilis as a medical-social problem. The characteristic views of respondents about prevention, possible ways of infection and the relationship to the self-treatment of syphilitic infection are described. Provides data about the negative consequences of untreated syphilis in the opinion of the respondents.

The article examines the issues of economic security. The operation of enterprises is being implemented in a volatile market environment, which requires a comprehensive assessment of not only the individual factors affecting the operation of the enterprise, but also encourages the need to develop a comprehensive system for the enterprise to ensure economic security. The purpose of this study is to examine the theoretical and methodological approaches to assessing and ensuring the economic security of the enterprise, the development of a mechanism to ensure the economic security of the enterprise. Measures to ensure the safety of personnel suggest preventive work with the personnel, training personnel of the security services division, formation of personnel reserve of security personnel, the organization of work with new employees, reducing staff turnover. Preventive measures to minimize include activities not directly related to the activities of security units, but to minimize losses of commercial enterprise in the course of maintenance operations: control of inventories; control document; scheduled and unscheduled inspections during the reception of the goods; selection and organization of the movement control risk goods. Development of guidelines and regulations involves the planning of a clear legal regulation of all processes for the operation of commercial facility, potentially dangerous from the point of view of any commercial activity or threats to the security risks. The success of the activities is largely determined by the speed and accuracy of enterprise responses to emerging threats, where a key determinant of the effectiveness of business, is to create a system to ensure the economic security of the enterprise.

In this paper we consider the formation of such an indicator of the urban environment as comfort. The aim of the study is to identify factors affecting this indicator and to draw up possible development paths in the conditions of our country. The main method used to study this topic is the analysis of received information on carrying out activities in foreign countries. As a result, it has been concluded that some projects can be implemented in Russia, but this topic requires more detailed study, as well as the development and implementation of a large number of projects in order to create a truly comfortable urban environment.

The aim of the work is to develop an algorithm for designing building constructions, namely their geometric construction (the geometrical location of points) in the form of an expression using the formula (equation) of geometric property of construction expressed in the projection by nonlinear functions. The article gives an algorithm for finding analytical dependencies of nonlinear functions used in applications. You must select a coordinate system before composing the curve equation. The type of the desired equation depends on the choice of the coordinate system. There are no rules that could guide one in choosing a coordinate system, and the ability to make the most rational choice is given only by experience. In this paper, the examples of the choice of coordinate systems show the form of functions, namely, their simplification. In some cases, geometric construction is the only way to present a graphic image of the building structure itself, no matter how complex it may be in the Cartesian coordinate system. The polar coordinate system is presented here as an alternative for unique structures and structures of increased complexity in the Cartesian coordinate system. This is achieved by establishing a relationship between the current coordinates of the point located on the projection of the construction and constants characterizing the properties of this construction, called a function on the plane and a surface in space in researches. The prospect of this approach has proven itself: in the construction of exquisite palace temples, beautiful architectural ensembles that make the space surrounding a person comfortable.

Приведены числа хромосом (2n) для 12 видов (8 семейств) сосудистых растений с острова Сахалин. Впервые установлены хромосомные числа для трех видов с Сахалина. Один вид исследован впервые для России и один – для российского Дальнего Востока.

Infections sexually transmitted and their complications lead to considerable social and economic expenses entering into ten the most frequent reasons of the request for medical care and making the essential item of expenditure both national budgets of health care and family expenses. Social expenses also include the conflicts between sexual partners and violence in their family.

Исследована эпидерма листьев у Conioselinum longifolium и C. tataricum трибы Ligusticeae сем. Apiaceae, собранных в Сибири. Изученные виды имеют гипостоматные листья и выявлено несколько типов устьичного аппарата: аномоцитный, анизоцитный, гемипарацитный, гемидиацитный. Иногда встречаются диацитные, парацитные и тетрацитные стоматотипы. На одном листе встречается одновременно несколько типов устьиц. Преобладающий тип устьиц – аномоцитный. Основными диагностическими признаками у изученных видов являются: количество устьиц и клеток на единице площади, форма и характер очертаний эпидермальных клеток, а также количество прилегающих к устьицам клеток. У обоих видов устьица окружены 3–6 клетками и наиболее распространенными являются аномоцитные устьица с 4 окружающими клетками, которых у C. tataricum в 2 раза больше, чем у C. longifolium. Аномоцитный тип у C. longifolium составляет 75 % от общего количества устьиц, C. tataricum имеет около 90 %. Устьичные комплексы с 6 соседними клетками встречаются очень редко. Число устьиц и клеток на 1 мм2 у C. longifolium приблизительно в 1,5 раза больше, чем у C. tataricum. Очертания эпидермальных клеток адаксиальной поверхности листа C. longifolium прямолинейно округлые, C. tataricum имеет крупно-извилистые стенки. На абаксиальной стороне очертания клеток извилистые и волнистые у C. longifolium, крупно-извилистые у C. tataricum. Встречаются устьица-близнецы и смежные устьица. Устьичные индексы отличаются незначительно. Вариабельность признаков эпидермы у изученных видов не превышает средний показатель., The leaf epidermis in Conioselinum longifolium and C. tataricum tribe Ligusticeae family Apiaceae has been studied. The plants have hypostomatous leaves, and anomocytic, anisocytic, gemiparacytic, gemidiacytic of stomatal apparatus identified. Sometimes there are diacytic, paracytic and tetracytic stomatotypes. The prevailing stomatal apparatus type is anomocytic. There are several types of stomata on the one leaf at the same time. The main diagnostic features in the studied species are: the number of cells and stomata per unit area, the shape and character of the outline of the epidermal cells and the number of cells adjacent to the stomata. Both types of stomatas surrounded by 3–6 cells. The most common type is anomocytic stomata surrounding 4 cells. Anomocytic type compiles 75 % of the total number of the stomatas, and C. tataricum has 90 % of the stomatas this type. Stomatal complexes with 6 neighboring cell are very rary. The number of the stomatas and cell per 1 mm2 in C. longifolium is about 1.5 times greater than in C. tataricum. Outlines of the leaf epidermal cells on the adaxial surface of C. longifolium are straight-forward rounded. C. tataricum has a large-winding wall of the cells. There are twisting and waving outlines of the epidermal cell on the abaxial side in C. longifolium, and large-twisting in C. tataricum. Stomatal index differs insig­nificantly. The variability of the characteristics of the leaf epidermis is less average.

The effect of heat exchange conditions during various vulcanizing methods is studied. A dependence of chemical resistance on temperature distribution through a coating thickness during heat treatment is demonstrated.

This paper investigates the interrelation between plastic-deformation and heat-and-mass exchange during fabrication of roll-formed sections fashioned from rubberized metallic sheets. A generalized expression is derived for determination of their maximum bend angle. The stresses in the compression and tension zones of the metallic base and rubber covering, and the radii of the neutral layer of a rubberized sheet subject to plastic deformation are determined.

Aim. To determine plasmic concentrations of NT-proBNP, TNFalpha and IL-6 in patients with coronary heart disease (CHD) complicated with chronic cardiac failure (CCF); to compare these parameters with hemodynamic and functional ones. Material and methods. A total of 157 CHD patients (84.1% males, mean age 54.3 ± 6.8 years) were divided into 3 groups matched by sex and age according to the presence of CCF and left ventricular (LV) or systolic dysfunction. Results. CCF patients with LV dysfunction or intact LV function had much higher plasmic concentrations of neurohumoral mediators than CHD patients without CCF. A plasmic NT-proBNP level over 1000 fmol/ml was associated with a 5.5-fold increase in the relative risk of LV diastolic dysfunction for CCF patients (rR 5.6; 95% CI 1.4-30.0; p = 0.0065) while an IL-6 level over 6.1 pg/ml was associated with a 9-fold increase in this risk (rR 8.9; 95% CI 2.3-35.4; p = 0.00001). Plasmic NT-proBNP and IL-6 levels went up in correlation with a CCF functional class. A plasmic level of TNFalpha correlated with anginal functional class. Conclusion. Changes in plasmic levels of the above neuromediators are associated with changes in some LV function and functional parameters of CCF patients.