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1. NFκB and NLRP3/NLRC4 inflammasomes regulate differentiation, activation and functional properties of monocytes in response to distinct SARS-CoV-2 proteins

Author

Tsukalov, Ilya, Sánchez-Cerrillo, Ildefonso, Rajas, Olga, Avalos, Elena, Iturricastillo, Gorane, Esparcia, Laura, Buzón, María José, Genescà, Meritxell, Scagnetti, Camila, Popova, Olga, Martin-Cófreces, Noa, Calvet-Mirabent, Marta, Marcos-Jimenez, Ana, Martínez-Fleta, Pedro, Delgado-Arévalo, Cristina, de los Santos, Ignacio, Muñoz-Calleja, Cecilia, Calzada, María José, González Álvaro, Isidoro, Palacios-Calvo, José, Alfranca, Arantzazu, Ancochea, Julio, Sánchez-Madrid, Francisco, and Martin-Gayo, Enrique

Published
2024
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2. Expanding HIV clinical monitoring: the role of CD4, CD8, and CD4/CD8 ratio in predicting non-AIDS events

Author

Jarrín, Inma, Dalmau, David, Navarro, M. Luisa, González, M. Isabel, Garcia, Federico, Poveda, Eva, Iribarren, Jose Antonio, Gutiérrez, Félix, Rubio, Rafael, Vidal, Francesc, Berenguer, Juan, González, Juan, Muñoz-Fernández, M. Ángeles, Jarrín, Inmaculada, Moreno, Cristina, Rava, Marta, Izquierdo, Rebeca, Mauleón, Elba, Portilla, Joaquín, Portilla, Irene, Merino, Esperanza, García, Gema, Agea, Iván, Sánchez-Payá, José, Rodríguez, Juan Carlos, Giner, Livia, Reus, Sergio, Boix, Vicente, Torrus, Diego, Pérez, Verónica, Portilla, Julia, Gómez, Juan Luís, Hernández, Jehovana, Lirola, Ana López, García, Dácil, Díaz-Flores, Felicitas, Alonso, M. Mar, Pelazas, Ricardo, Alemán, M. Remedios, Asensi, Víctor, Rivas Carmenado, María Eugenia, Suarez-Zarracina, Tomás, Pulido, Federico, Bisbal, Otilia, Hernando, M. Asunción, Rial, David, de Lagarde, María, Arce, Octavio, Pinto, Adriana, Bermejo, Laura, Santacreu, Mireia, Navarro, Roser, Gonzalez, Candela, Aramburu, M. José, Camino, Xabier, Ángel von Wichmann, Miguel, Goenaga, Miguel Ángel, Bustinduy, M. Jesús, Azkune, Harkaitz, Ibarguren, Maialen, Kortajarena, Xabier, Álvarez-Rodriguez, Ignacio, Gil, Leire, Martínez, Lourdes, Robledano, Catalina, Masiá, Mar, Padilla, Sergio, Adsuar, Araceli, Pascual, Rafael, Fernández, Marta, Galiana, Antonio, García, José Alberto, Barber, Xavier, Agullo, Vanessa, Abellán, Javier Garcia, Pascual, Reyes, Telenti, Guillermo, Guillén, Lucia, Botella, Ángela, Muga, Roberto, Sanvisens, Arantza, Fuster, Daniel, Gutierrez, Isabel, López, Juan Carlos, Ramírez, Margarita, Padilla, Belén, Gijón, Paloma, Aldamiz-Echevarría, Teresa, Tejerina, Francisco, Diez, Cristina, Pérez, Leire, Fanciulli, Chiara, Corral, Saray, Martí, Anna, Peraire, Joaquín, Viladés, Consuelo, Vargas, Montserrat, Olona, Montserrat, Rull, Anna, Alba, Verónica, Yeregui, Elena, Masip, Jenifer, García-Pardo, Graciano, Bertomeu, Frederic Gómez, Espineira, Sonia, Montero, Marta, Cuéllar, Sandra, Blanes, Marino, Tasias, María, Calabuig, Eva, Salavert, Miguel, Fernández, Juan, Segarra, Inmaculada, González-García, Juan, Delgado, Ana, Arnalich, Francisco, Arribas, José Ramón, Bernardino, Jose Ignacio, Castro, Juan Miguel, Escosa, Luis, Herranz, Pedro, Hontañón, Victor, García-Bujalance, Silvia, García, Milagros, González-Baeza, Alicia, Martín-Carbonero, M. Luz, Mayoral, Mario, Mellado, M. Jose, Esteban, Rafael, Montejano, Rocío, Montes, M. Luisa, Moreno, Victoria, Pérez-Valero, Ignacio, Rodés, Berta, Rúa, Guadalupe, Sainz, Talía, Sendagorta, Elena, Valencia, Eulalia, Busca, Carmen, Cano, Joanna, Cardiñanos, Julen, de Miguel, Rosa, Blanco, Jose Ramón, Pérez-Martínez, Laura, Oteo, José Antonio, Ibarra, Valvanera, Metola, Luis, Sanz, Mercedes, Arazo, Piedad, Sampériz, Gloria, Martinez, Marina, Jaén, Angels, Sanmartí, Montse, Cairó, Mireia, Martinez-Lacasa, Javier, Velli, Pablo, Font, Roser, Xercavins, Mariona, Alonso, Noemí, Aiello, Francesco, Rivero, María, Piérola, Beatriz, Goikoetxea, Maider, Gracia, María, Ibero, Carlos, Moreno, Estela, Repáraz, Jesús, Navarro, Gemma, Garcia, Manel Cervantes, Isbert, Sonia Calzado, Vilasaro, Marta Navarro, Garcia, Belen Lopez, Santos, Ignacio de los, Santos, Alejandro de los, Sanz, Jesús, García-Fraile, Lucio, Martín, Enrique, Sánchez-Cerrillo, Ildefonso, Calvet, Marta, Barrios, Ana, Bautista, Azucena, Sáez, Carmen, Ciudad, Marianela, Gutiérrez, Ángela, Moreno, Santiago, Campo, Santos del, Casado, José Luis, Dronda, Fernando, Moreno, Ana, Pérez, M. Jesús, Serrano, Sergio, Vivancos, M<ce:sup loc='post">a</ce:sup> Jesús, Martínez-Sanz, Javier, Vallejo, Alejandro, Sanchez, Matilde, Pérez-Molina, Jose Antonio, Hermida, José Manuel, Bernal, Enrique, Alcaraz, Antonia, Bravo, Joaquín, Muñoz, Ángeles, Tomás, Cristina, Martínez, Mónica, Villalba, M. Carmen, García, Federico, Martínez, Clara, Hernández, José, Medina, Leopoldo Muñoz, Álvarez, Marta, Chueca, Natalia, Vinuesa, David, de Salazar, Adolfo, Fuentes, Ana, Guirao, Emilio, Viñuela, Laura, Ruiz-Sancho, Andrés, Anguita, Francisco, Del Romero, Jorge, Raposo, Montserrat, Rodríguez, Carmen, Puerta, Teresa, Carrió, Juan Carlos, Vera, Mar, Ballesteros, Juan, Ayerdi, Oskar, Baza, Begoña, Orviz, Eva, Antela, Antonio, Losada, Elena, Riera, Melchor, Peñaranda, María, Ribas, M. Angels, Campins, Antoni A., Garcia-Gazalla, Mercedes, Fanjul, Francisco J., Murillas, Javier, Homar, Francisco, Vilchez, Helem H., Martin, Luisa, Payeras, Antoni, Santos, Jesús, López, María, Gómez, Crisitina, Viciana, Isabel, Palacios, Rosario, López-Cortés, Luis Fernando, Espinosa, Nuria, Roca, Cristina, Llaves, Silvia, Tiraboschi, Juan Manuel, Imaz, Arkaitz, Silva, Ana Karina, Saumoy, María, Scévola, Sofía Catalina, Curran, Adrián, Falcó, Vicenç, Navarro, Jordi, Burgos, Joaquin, Suanzes, Paula, García, Jorge, Descalzo, Vicente, Álvarez, Patricia, Planas, Bibiana, Sanchiz, Marta, Rodríguez, Lucía, Olalla, Julián, Sánchez, M José, Pérez, Javier, Arco, Alfonso del, Torre, Javier de la, Prada, José Luis, Martínez, Onofre Juan, Martinez, Lorena, Vera, Francisco Jesús, García, Josefina, Alcaraz, Begoña, Sánchez Guirao, Antonio Jesús, Mena, Alvaro, Castro, Angeles, Pernas, Berta, Vázquez, Pilar, López, Soledad, Ibarra, Sofía, García, Guillermo, Mirena, Josu, Ferrero, Oscar Luis, López, Josefina, Cámara, M. Mar, Peña, Mireia de la, Lopez, Miriam, Lopez, Iñigo, Lombide, Itxaso, Polo, Victor, de Miguel, Joana, Galera, Carlos, Fernández, Marian, Albendin, Helena, Castillo, Antonia, Iborra, Asunción, Moreno, Antonio, Merlos, M. Angustias, Vidal, Asunción, Amador, Concha, Pasquau, Francisco, Gil, Concepcion, Algado, Jose Tomás, Suarez-García, Inés, Malmierca, Eduardo, González-Ruano, Patricia, Ruiz, M. Pilar, Pascual, José Francisco, Sáez, Elena, Balsalobre, Luz, López, M. Villa, Omar, Mohamed, Herrero, Carmen, Gómez, M. Amparo, Alberto de Zarraga, Miguel, Pérez, Desiré, Estrada, Vicente, Sanz, Nieves, Cabello, Noemí, García, Jorge Vergas, Núñez, Maria Jose, Sagastagoitia, Iñigo, Górgolas, Miguel, Cabello, Alfonso, Álvarez, Beatriz, Prieto, Laura, Carrillo, Irene, Sanz, José, Arranz, Alberto, Hernández, Cristina, Novella, María, Galindo, M. José, Ferrer, Ana, Román, Antonio Rivero, Ruíz, Inma, Juárez, Antonio Rivero, López, Pedro, Machuca, Isabel, Frias, Mario, Camacho, Ángela, Pérez, Ignacio, Corona, Diana, Cervero, Miguel, Torres, Rafael, Pineda, Juan Antonio, Rincón, Pilar, Macías, Juan, Real, Luis Miguel, Corma, Anais, Gonzalez-Serna, Alejandro, Pérez, Alexandre, Morano, Luis, Miralles, Celia, Ocampo, Antonio, Pousada, Guillermo, Patiño, Lucía, Dueñas, Carlos, Gutiérrez, Sara, Tapia, Elena, Novoa, Cristina, Egües, Xjoylin, Telleria, Pablo, Díaz-Álvarez, Jorge, Rosas Cancio-Suarez, Marta, Ron, Raquel, Iribarren, José Antonio, Ruiz Sancho, Andrés, Cabello, Noemi, and Serrano-Villar, Sergio

Published
2023
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3. Antiretroviral therapy duration and immunometabolic state determine efficacy of ex vivo dendritic cell-based treatment restoring functional HIV-specific CD8+ T cells in people living with HIV

Author

Calvet-Mirabent, Marta, Sánchez-Cerrillo, Ildefonso, Martín-Cófreces, Noa, Martínez-Fleta, Pedro, de la Fuente, Hortensia, Tsukalov, Ilya, Delgado-Arévalo, Cristina, Calzada, María José, de los Santos, Ignacio, Sanz, Jesús, García-Fraile, Lucio, Sánchez-Madrid, Francisco, Alfranca, Arantzazu, Muñoz-Fernández, María Ángeles, Buzón, Maria J., and Martín-Gayo, Enrique

Published
2022
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4. Single-cell multi-omics analysis of COVID-19 patients with pre-existing autoimmune diseases shows aberrant immune responses to infection

Author

Gates Cambridge Scholarships, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Chan Zuckerberg Biohub, Wellcome Sanger Institute, Josep Carreras Leukemia Foundation, Andrés-León, Eduardo [0000-0002-0621-9914], https://ror.org/02gfc7t72, Barmada, Anis, Handfield, Louis-François, Godoy-Tena, Gerard, de la Calle-Fabregat, Carlos, Ciudad, Laura, Arutyunyan, Anna, Andrés-León, Eduardo, Hoo, Regina, Porter, Tarryn, Oszlanczi, Agnes, Richardson, Laura, Calero-Nieto, Fernando J., Wilson, Nicola K., Marchese, Domenica, Sancho-Serra, Carmen, Carrillo, Jorge, Presas-Rodríguez, Silvia, Ramo-Tello, Cristina, Ruiz-Sanmartin, Adolfo, Ferrer, Ricard, Ruiz-Rodriguez, Juan Carlos, Martínez-Gallo, Mónica, Munera-Campos, Mónica, Carrascosa, Jose Manuel, Göttgens, Berthold, Heyn, Holger, Prigmore, Elena, Casafont-Solé, Ivette, Solanich, Xavier, Sánchez-Cerrillo, Ildefonso, González-Álvaro, Isidoro, Raimondo, Maria Gabriella, Ramming, Andreas, Martin, Javier, Martínez-Cáceres, Eva, Ballestar, Esteban, Vento-Tormo, Roser, Rodríguez-Ubreva, Javier, Gates Cambridge Scholarships, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Chan Zuckerberg Biohub, Wellcome Sanger Institute, Josep Carreras Leukemia Foundation, Andrés-León, Eduardo [0000-0002-0621-9914], https://ror.org/02gfc7t72, Barmada, Anis, Handfield, Louis-François, Godoy-Tena, Gerard, de la Calle-Fabregat, Carlos, Ciudad, Laura, Arutyunyan, Anna, Andrés-León, Eduardo, Hoo, Regina, Porter, Tarryn, Oszlanczi, Agnes, Richardson, Laura, Calero-Nieto, Fernando J., Wilson, Nicola K., Marchese, Domenica, Sancho-Serra, Carmen, Carrillo, Jorge, Presas-Rodríguez, Silvia, Ramo-Tello, Cristina, Ruiz-Sanmartin, Adolfo, Ferrer, Ricard, Ruiz-Rodriguez, Juan Carlos, Martínez-Gallo, Mónica, Munera-Campos, Mónica, Carrascosa, Jose Manuel, Göttgens, Berthold, Heyn, Holger, Prigmore, Elena, Casafont-Solé, Ivette, Solanich, Xavier, Sánchez-Cerrillo, Ildefonso, González-Álvaro, Isidoro, Raimondo, Maria Gabriella, Ramming, Andreas, Martin, Javier, Martínez-Cáceres, Eva, Ballestar, Esteban, Vento-Tormo, Roser, and Rodríguez-Ubreva, Javier

Abstract

In COVID-19, hyperinflammatory and dysregulated immune responses contribute to severity. Patients with pre-existing autoimmune conditions can therefore be at increased risk of severe COVID-19 and/or associated sequelae, yet SARS-CoV-2 infection in this group has been little studied. Here, we performed single-cell analysis of peripheral blood mononuclear cells from patients with three major autoimmune diseases (rheumatoid arthritis, psoriasis, or multiple sclerosis) during SARS-CoV-2 infection. We observed compositional differences between the autoimmune disease groups coupled with altered patterns of gene expression, transcription factor activity, and cell-cell communication that substantially shape the immune response under SARS-CoV-2 infection. While enrichment of HLA-DRlow CD14+ monocytes was observed in all three autoimmune disease groups, type-I interferon signaling as well as inflammatory T cell and monocyte responses varied widely between the three groups of patients. Our results reveal disturbed immune responses to SARS-CoV-2 in patients with pre-existing autoimmunity, highlighting important considerations for disease treatment and follow-up.

Published
2024

5. MICa/b‐dependent activation of natural killer cells by CD64+ inflammatory type 2 dendritic cells contributes to autoimmunity

Author

Sánchez‐Cerrillo, Ildefonso, primary, Calzada‐Fraile, Diego, additional, Triguero‐Martínez, Ana, additional, Calvet‐Mirabent, Marta, additional, Popova, Olga, additional, Delgado‐Arévalo, Cristina, additional, Valdivia‐Mazeyra, Mariel, additional, Ramírez‐Huesca, Marta, additional, de Luis, Enrique Vázquez, additional, Benguría, Alberto, additional, Aceña‐Gonzalo, Teresa, additional, Moreno‐Vellisca, Roberto, additional, de Llano, Magdalena Adrados, additional, de la Fuente, Hortensia, additional, Tsukalov, Ilya, additional, Delgado‐Wicke, Pablo, additional, Fernández‐Ruiz, Elena, additional, Roy‐Vallejo, Emilia, additional, Tejedor‐Lázaro, Reyes, additional, Ramiro, Almudena, additional, Iborra, Salvador, additional, Sánchez‐Madrid, Francisco, additional, Dopazo, Ana, additional, Álvaro, Isidoro González, additional, Castañeda, Santos, additional, and Martin‐Gayo, Enrique, additional

Published
2023
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6. Expanding HIV clinical monitoring: the role of CD4, CD8, and CD4/CD8 ratio in predicting non-AIDS events

Author

Martínez-Sanz, Javier, primary, Díaz-Álvarez, Jorge, additional, Rosas Cancio-Suarez, Marta, additional, Ron, Raquel, additional, Iribarren, José Antonio, additional, Bernal, Enrique, additional, Gutiérrez, Félix, additional, Ruiz Sancho, Andrés, additional, Cabello, Noemi, additional, Olalla, Julián, additional, Moreno, Santiago, additional, Serrano-Villar, Sergio, additional, Jarrín, Inma, additional, Dalmau, David, additional, Navarro, M. Luisa, additional, González, M. Isabel, additional, Garcia, Federico, additional, Poveda, Eva, additional, Iribarren, Jose Antonio, additional, Rubio, Rafael, additional, Vidal, Francesc, additional, Berenguer, Juan, additional, González, Juan, additional, Muñoz-Fernández, M. Ángeles, additional, Jarrín, Inmaculada, additional, Moreno, Cristina, additional, Rava, Marta, additional, Izquierdo, Rebeca, additional, Mauleón, Elba, additional, Portilla, Joaquín, additional, Portilla, Irene, additional, Merino, Esperanza, additional, García, Gema, additional, Agea, Iván, additional, Sánchez-Payá, José, additional, Rodríguez, Juan Carlos, additional, Giner, Livia, additional, Reus, Sergio, additional, Boix, Vicente, additional, Torrus, Diego, additional, Pérez, Verónica, additional, Portilla, Julia, additional, Gómez, Juan Luís, additional, Hernández, Jehovana, additional, Lirola, Ana López, additional, García, Dácil, additional, Díaz-Flores, Felicitas, additional, Alonso, M. Mar, additional, Pelazas, Ricardo, additional, Alemán, M. Remedios, additional, Asensi, Víctor, additional, Rivas Carmenado, María Eugenia, additional, Suarez-Zarracina, Tomás, additional, Pulido, Federico, additional, Bisbal, Otilia, additional, Hernando, M. Asunción, additional, Rial, David, additional, de Lagarde, María, additional, Arce, Octavio, additional, Pinto, Adriana, additional, Bermejo, Laura, additional, Santacreu, Mireia, additional, Navarro, Roser, additional, Gonzalez, Candela, additional, Aramburu, M. José, additional, Camino, Xabier, additional, Ángel von Wichmann, Miguel, additional, Goenaga, Miguel Ángel, additional, Bustinduy, M. Jesús, additional, Azkune, Harkaitz, additional, Ibarguren, Maialen, additional, Kortajarena, Xabier, additional, Álvarez-Rodriguez, Ignacio, additional, Gil, Leire, additional, Martínez, Lourdes, additional, Robledano, Catalina, additional, Masiá, Mar, additional, Padilla, Sergio, additional, Adsuar, Araceli, additional, Pascual, Rafael, additional, Fernández, Marta, additional, Galiana, Antonio, additional, García, José Alberto, additional, Barber, Xavier, additional, Agullo, Vanessa, additional, Abellán, Javier Garcia, additional, Pascual, Reyes, additional, Telenti, Guillermo, additional, Guillén, Lucia, additional, Botella, Ángela, additional, Muga, Roberto, additional, Sanvisens, Arantza, additional, Fuster, Daniel, additional, Gutierrez, Isabel, additional, López, Juan Carlos, additional, Ramírez, Margarita, additional, Padilla, Belén, additional, Gijón, Paloma, additional, Aldamiz-Echevarría, Teresa, additional, Tejerina, Francisco, additional, Diez, Cristina, additional, Pérez, Leire, additional, Fanciulli, Chiara, additional, Corral, Saray, additional, Martí, Anna, additional, Peraire, Joaquín, additional, Viladés, Consuelo, additional, Vargas, Montserrat, additional, Olona, Montserrat, additional, Rull, Anna, additional, Alba, Verónica, additional, Yeregui, Elena, additional, Masip, Jenifer, additional, García-Pardo, Graciano, additional, Bertomeu, Frederic Gómez, additional, Espineira, Sonia, additional, Montero, Marta, additional, Cuéllar, Sandra, additional, Blanes, Marino, additional, Tasias, María, additional, Calabuig, Eva, additional, Salavert, Miguel, additional, Fernández, Juan, additional, Segarra, Inmaculada, additional, González-García, Juan, additional, Delgado, Ana, additional, Arnalich, Francisco, additional, Arribas, José Ramón, additional, Bernardino, Jose Ignacio, additional, Castro, Juan Miguel, additional, Escosa, Luis, additional, Herranz, Pedro, additional, Hontañón, Victor, additional, García-Bujalance, Silvia, additional, García, Milagros, additional, González-Baeza, Alicia, additional, Martín-Carbonero, M. Luz, additional, Mayoral, Mario, additional, Mellado, M. Jose, additional, Esteban, Rafael, additional, Montejano, Rocío, additional, Montes, M. Luisa, additional, Moreno, Victoria, additional, Pérez-Valero, Ignacio, additional, Rodés, Berta, additional, Rúa, Guadalupe, additional, Sainz, Talía, additional, Sendagorta, Elena, additional, Valencia, Eulalia, additional, Busca, Carmen, additional, Cano, Joanna, additional, Cardiñanos, Julen, additional, de Miguel, Rosa, additional, Blanco, Jose Ramón, additional, Pérez-Martínez, Laura, additional, Oteo, José Antonio, additional, Ibarra, Valvanera, additional, Metola, Luis, additional, Sanz, Mercedes, additional, Arazo, Piedad, additional, Sampériz, Gloria, additional, Martinez, Marina, additional, Jaén, Angels, additional, Sanmartí, Montse, additional, Cairó, Mireia, additional, Martinez-Lacasa, Javier, additional, Velli, Pablo, additional, Font, Roser, additional, Xercavins, Mariona, additional, Alonso, Noemí, additional, Aiello, Francesco, additional, Rivero, María, additional, Piérola, Beatriz, additional, Goikoetxea, Maider, additional, Gracia, María, additional, Ibero, Carlos, additional, Moreno, Estela, additional, Repáraz, Jesús, additional, Navarro, Gemma, additional, Garcia, Manel Cervantes, additional, Isbert, Sonia Calzado, additional, Vilasaro, Marta Navarro, additional, Garcia, Belen Lopez, additional, Santos, Ignacio de los, additional, Santos, Alejandro de los, additional, Sanz, Jesús, additional, García-Fraile, Lucio, additional, Martín, Enrique, additional, Sánchez-Cerrillo, Ildefonso, additional, Calvet, Marta, additional, Barrios, Ana, additional, Bautista, Azucena, additional, Sáez, Carmen, additional, Ciudad, Marianela, additional, Gutiérrez, Ángela, additional, Campo, Santos del, additional, Casado, José Luis, additional, Dronda, Fernando, additional, Moreno, Ana, additional, Pérez, M. Jesús, additional, Serrano, Sergio, additional, Vivancos, Ma Jesús, additional, Martínez-Sanz, Javier, additional, Vallejo, Alejandro, additional, Sanchez, Matilde, additional, Pérez-Molina, Jose Antonio, additional, Hermida, José Manuel, additional, Alcaraz, Antonia, additional, Bravo, Joaquín, additional, Muñoz, Ángeles, additional, Tomás, Cristina, additional, Martínez, Mónica, additional, Villalba, M. Carmen, additional, García, Federico, additional, Martínez, Clara, additional, Hernández, José, additional, Medina, Leopoldo Muñoz, additional, Álvarez, Marta, additional, Chueca, Natalia, additional, Vinuesa, David, additional, de Salazar, Adolfo, additional, Fuentes, Ana, additional, Guirao, Emilio, additional, Viñuela, Laura, additional, Ruiz-Sancho, Andrés, additional, Anguita, Francisco, additional, Del Romero, Jorge, additional, Raposo, Montserrat, additional, Rodríguez, Carmen, additional, Puerta, Teresa, additional, Carrió, Juan Carlos, additional, Vera, Mar, additional, Ballesteros, Juan, additional, Ayerdi, Oskar, additional, Baza, Begoña, additional, Orviz, Eva, additional, Antela, Antonio, additional, Losada, Elena, additional, Riera, Melchor, additional, Peñaranda, María, additional, Ribas, M. Angels, additional, Campins, Antoni A., additional, Garcia-Gazalla, Mercedes, additional, Fanjul, Francisco J., additional, Murillas, Javier, additional, Homar, Francisco, additional, Vilchez, Helem H., additional, Martin, Luisa, additional, Payeras, Antoni, additional, Santos, Jesús, additional, López, María, additional, Gómez, Crisitina, additional, Viciana, Isabel, additional, Palacios, Rosario, additional, López-Cortés, Luis Fernando, additional, Espinosa, Nuria, additional, Roca, Cristina, additional, Llaves, Silvia, additional, Tiraboschi, Juan Manuel, additional, Imaz, Arkaitz, additional, Silva, Ana Karina, additional, Saumoy, María, additional, Scévola, Sofía Catalina, additional, Curran, Adrián, additional, Falcó, Vicenç, additional, Navarro, Jordi, additional, Burgos, Joaquin, additional, Suanzes, Paula, additional, García, Jorge, additional, Descalzo, Vicente, additional, Álvarez, Patricia, additional, Planas, Bibiana, additional, Sanchiz, Marta, additional, Rodríguez, Lucía, additional, Sánchez, M José, additional, Pérez, Javier, additional, Arco, Alfonso del, additional, Torre, Javier de la, additional, Prada, José Luis, additional, Martínez, Onofre Juan, additional, Martinez, Lorena, additional, Vera, Francisco Jesús, additional, García, Josefina, additional, Alcaraz, Begoña, additional, Sánchez Guirao, Antonio Jesús, additional, Mena, Alvaro, additional, Castro, Angeles, additional, Pernas, Berta, additional, Vázquez, Pilar, additional, López, Soledad, additional, Ibarra, Sofía, additional, García, Guillermo, additional, Mirena, Josu, additional, Ferrero, Oscar Luis, additional, López, Josefina, additional, Cámara, M. Mar, additional, Peña, Mireia de la, additional, Lopez, Miriam, additional, Lopez, Iñigo, additional, Lombide, Itxaso, additional, Polo, Victor, additional, de Miguel, Joana, additional, Galera, Carlos, additional, Fernández, Marian, additional, Albendin, Helena, additional, Castillo, Antonia, additional, Iborra, Asunción, additional, Moreno, Antonio, additional, Merlos, M. Angustias, additional, Vidal, Asunción, additional, Amador, Concha, additional, Pasquau, Francisco, additional, Gil, Concepcion, additional, Algado, Jose Tomás, additional, Suarez-García, Inés, additional, Malmierca, Eduardo, additional, González-Ruano, Patricia, additional, Ruiz, M. Pilar, additional, Pascual, José Francisco, additional, Sáez, Elena, additional, Balsalobre, Luz, additional, López, M. Villa, additional, Omar, Mohamed, additional, Herrero, Carmen, additional, Gómez, M. Amparo, additional, Alberto de Zarraga, Miguel, additional, Pérez, Desiré, additional, Estrada, Vicente, additional, Sanz, Nieves, additional, Cabello, Noemí, additional, García, Jorge Vergas, additional, Núñez, Maria Jose, additional, Sagastagoitia, Iñigo, additional, Górgolas, Miguel, additional, Cabello, Alfonso, additional, Álvarez, Beatriz, additional, Prieto, Laura, additional, Carrillo, Irene, additional, Sanz, José, additional, Arranz, Alberto, additional, Hernández, Cristina, additional, Novella, María, additional, Galindo, M. José, additional, Ferrer, Ana, additional, Román, Antonio Rivero, additional, Ruíz, Inma, additional, Juárez, Antonio Rivero, additional, López, Pedro, additional, Machuca, Isabel, additional, Frias, Mario, additional, Camacho, Ángela, additional, Pérez, Ignacio, additional, Corona, Diana, additional, Cervero, Miguel, additional, Torres, Rafael, additional, Pineda, Juan Antonio, additional, Rincón, Pilar, additional, Macías, Juan, additional, Real, Luis Miguel, additional, Corma, Anais, additional, Gonzalez-Serna, Alejandro, additional, Pérez, Alexandre, additional, Morano, Luis, additional, Miralles, Celia, additional, Ocampo, Antonio, additional, Pousada, Guillermo, additional, Patiño, Lucía, additional, Dueñas, Carlos, additional, Gutiérrez, Sara, additional, Tapia, Elena, additional, Novoa, Cristina, additional, Egües, Xjoylin, additional, and Telleria, Pablo, additional

Published
2023
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7. MICa/b‐dependent activation of natural killer cells by CD64+ inflammatory type 2 dendritic cells contributes to autoimmunity.

Author

Sánchez‐Cerrillo, Ildefonso, Calzada‐Fraile, Diego, Triguero‐Martínez, Ana, Calvet‐Mirabent, Marta, Popova, Olga, Delgado‐Arévalo, Cristina, Valdivia‐Mazeyra, Mariel, Ramírez‐Huesca, Marta, de Luis, Enrique Vázquez, Benguría, Alberto, Aceña‐Gonzalo, Teresa, Moreno‐Vellisca, Roberto, de Llano, Magdalena Adrados, de la Fuente, Hortensia, Tsukalov, Ilya, Delgado‐Wicke, Pablo, Fernández‐Ruiz, Elena, Roy‐Vallejo, Emilia, Tejedor‐Lázaro, Reyes, and Ramiro, Almudena

Subjects
*KILLER cells, *DENDRITIC cells, *INTERFERON receptors, *INTERFERON gamma, *SJOGREN'S syndrome, *AUTOIMMUNITY
Abstract

Primary Sjögren's syndrome (pSS) is an inflammatory autoimmune disorder largely mediated by type I and II interferon (IFN). The potential contribution of innate immune cells, such as natural killer (NK) cells and dendritic cells (DC), to the pSS pathology remains understudied. Here, we identified an enriched CD16+ CD56hi NK cell subset associated with higher cytotoxic function, as well as elevated proportions of inflammatory CD64+ conventional dendritic cell (cDC2) subtype that expresses increased levels of MICa/b, the ligand for the activating receptor NKG2D, in pSS individuals. Circulating cDC2 from pSS patients efficiently induced activation of cytotoxic NK cells ex vivo and were found in proximity to CD56+ NK cells in salivary glands (SG) from pSS patients. Interestingly, transcriptional activation of IFN signatures associated with the RIG‐I/DDX60 pathway, IFN I receptor, and its target genes regulate the expression of NKG2D ligands on cDC2 from pSS patients. Finally, increased proportions of CD64hi RAE‐1+ cDC2 and NKG2D+CD11b+CD27+ NK cells were present in vivo in the SG after poly I:C injection. Our study provides novel insight into the contribution and interplay of NK and cDC2 in pSS pathology and identifies new potential therapy targets. Synopsis: Primary Sjögren´s syndrome (pSS) is an autoimmune disease characterized by inflammation and the development of autoimmunity. Here, we provide phenotypical and functional characteristics of the contribution of innate immune cells, such as natural killer (NK) and dendritic cell (DC) subsets, to pSS pathology. pSS patients show increased proportions of a high cytotoxicity‐associated CD16+ CD56hi NK subset.pSS patients show elevated levels of inflammatory CD64+ dendritic cell subset (cDC2) that expresses increased levels of MICa/b, a ligand for the activating receptor NKG2D.MICa/b expression in cDC2 is upregulated in response to poly I:C stimulation and associated with RIG‐I‐IFN‐INF Receptor signaling.In vivo activation of the RIG‐I/TLR3 pathway leads to recruitment of NK cells and cDC2 to salivary glands and their activation similar to what is seen in pSS patients. [ABSTRACT FROM AUTHOR]

Published
2023
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8. NLRC4-mediated activation of CD1c+ DC contributes to perpetuation of synovitis in rheumatoid arthritis

Author

Delgado-Arévalo, Cristina, primary, Calvet-Mirabent, Marta, additional, Triguero-Martínez, Ana, additional, Vázquez de Luis, Enrique, additional, Benguría-Filippini, Alberto, additional, Largo, Raquel, additional, Calzada-Fraile, Diego, additional, Popova, Olga, additional, Sánchez-Cerrillo, Ildefonso, additional, Tsukalov, Ilya, additional, Moreno-Vellisca, Roberto, additional, de la Fuente, Hortensia, additional, Herrero-Beaumont, Gabriel, additional, Ramiro, Almudena, additional, Sánchez-Madrid, Francisco, additional, Castañeda, Santos, additional, Dopazo, Ana, additional, González Álvaro, Isidoro, additional, and Martin-Gayo, Enrique, additional

Published
2022
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9. NLRC4 -mediated activation of CD1c+ dendritic cells contributes to perpetuation of synovitis in rheumatoid arthritis

Author

Delgado-Arévalo, Cristina, Calvet-Mirabent, Marta, Triguero-Martinez, Ana, Vázquez de Luis, Enrique, Benguría-Filippini, Alberto, Largo, Raquel, Calzada-Fraile, Diego, Popova, Olga, Sánchez-Cerrillo, Ildefonso, Tsukalov, Ilya, Moreno-Vellisca, Roberto, de la Fuente, Hortensia, Herrero-Beaumont, Gabriel, Ramiro, Almudena R, Sánchez-Madrid, Francisco, Castañeda, Santos, Dopazo, Ana, González-Álvaro, Isidoro, Martin-Gayo, Enrique, Comunidad de Madrid (España), Ramón y Cajal Program, Ministerio de Economía y Competitividad (España), Fundación La Caixa, Fundación La Marató TV3, Ministerio de Ciencia e Innovación (España), Instituto de Salud Carlos III, and Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)

Abstract

The individual contribution of specific myeloid subsets such as CD1c+ conventional dendritic cells (cDC) to perpetuation of Rheumatoid Arthritis (RA) pathology remains unclear. In addition, the specific innate sensors driving pathogenic activation of CD1c+ cDCs in RA patients and their functional implications have not been characterized. Here, we assessed phenotypical, transcriptional and functional characteristics of CD1c+ and CD141+ cDCs and monocytes from the blood and synovial fluid of RA patients. Increased levels of CCR2 and the IgG receptor CD64 on circulating CD1c+ cDC associated with the presence of this DC subset in the synovial membrane in RA patients. Moreover, synovial CD1c+ cDCs are characterized by increased expression of proinflammatory cytokines and high abilities to induce pathogenic IFNγ+IL-17+ CD4+ T cells in vitro. Finally, we identified the crosstalk between Fcγ Receptors and NLRC4 as a new potential molecular mechanism mediating pathogenic activation, CD64 upregulation and functional specialization of CD1c+ cDCs in response to dsDNA-IgG in RA patients. E.M.G. was supported by Comunidad de Madrid Talento Program (2017-T1/BMD5396), Ramón y Cajal Program (RYC2018-024374-I), the MINECO RETOS program (RTI2018-097485-A-I00), La Caixa Foundation (HR20-00218), CIBERINF (CB21/13/00107) and the TV3 Marató (REDINCOV). C.D.A. was supported by Comunidad de Madrid Talento Program (2017-T1/BMD-5396). M.C.M was supported by the NIH (R21AI140930). HR17-00016 grant from “La Caixa Banking Foundation to F.S.M also supported the study. D.C-F. is supported by the Fellowship “la Caixa” Foundation LCF/BQ/DR19/11740010. A.T.M. was supported by a PhD fellowship from the Autonomous Region of Madrid (PEJD-2019-PRE/BMD-16851) and the RD21/0002/0027 grant. R.L. and G.H.B. were supported by PI18/00261 AND PI20/00349 grants from Ministerio de Ciencia e Innovación and Instituto de Salud Carlos III, respectively. O.P. was supported by the TV3 Marató (REDINCOV) and I.T. was funded by grant for the promotion of research studies master-UAM 2021. S.C. was supported by PI21/01474 grant from the Instituto de Salud Carlos III and co-funded by The European Regional Development Fund (ERDF). I.G.A was supported by RD21/0002/0027 and PI21/00526 grants from the Spanish MINECO and Instituto de Salud Carlos III and co-funded by The European Regional Development Fund (ERDF) “A way to make Europe. Sí

Published
2022

10. COVID-19 severity associates with pulmonary redistribution of CD1c+ DCs and inflammatory transitional and nonclassical monocytes

Author

Sánchez-Cerrillo, Ildefonso, primary, Landete, Pedro, additional, Aldave, Beatriz, additional, Sánchez-Alonso, Santiago, additional, Sánchez-Azofra, Ana, additional, Marcos-Jiménez, Ana, additional, Ávalos, Elena, additional, Alcaraz-Serna, Ana, additional, de los Santos, Ignacio, additional, Mateu-Albero, Tamara, additional, Esparcia, Laura, additional, López-Sanz, Celia, additional, Martínez-Fleta, Pedro, additional, Gabrie, Ligia, additional, del Campo Guerola, Luciana, additional, de la Fuente, Hortensia, additional, Calzada, María J., additional, González-Álvaro, Isidoro, additional, Alfranca, Arantzazu, additional, Sánchez-Madrid, Francisco, additional, Muñoz-Calleja, Cecilia, additional, Soriano, Joan B., additional, Ancochea, Julio, additional, and Martín-Gayo, Enrique, additional

Published
2020
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11. Deregulated cellular circuits driving immunoglobulins and complement consumption associate with the severity of COVID‐19 patients

Author

Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Fundación la Caixa, European Commission, Comunidad de Madrid, Marcos Jiménez, Ana, Sánchez‐Alonso, Santiago, Alcaraz‐Serna, Ana, Esparcia-Pinedo, Laura, López‐Sanz, Celia, Sampedro-Nuñez, Miguel, Mateu‐Albero, Tamara, Sánchez‐Cerrillo, Ildefonso, Martínez‐Fleta, Petra, Gabrie, Ligia, Campo Guerola, Luciana del, Rodríguez-Frade, José Miguel, Casasnovas, José María, Reyburn, H. T., Valés-Gómez, Mar, López Trascasa, Margarita, Martín‐Gayo, Enrique, Calzada, María José, Castañeda, Santos, Fuente, Hortensia de la, González-Álvaro, Isidoro, Sánchez‐Madrid, Francisco, Muñoz‐Calleja, Cecilia, Alfranca, Arántzazu, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Fundación la Caixa, European Commission, Comunidad de Madrid, Marcos Jiménez, Ana, Sánchez‐Alonso, Santiago, Alcaraz‐Serna, Ana, Esparcia-Pinedo, Laura, López‐Sanz, Celia, Sampedro-Nuñez, Miguel, Mateu‐Albero, Tamara, Sánchez‐Cerrillo, Ildefonso, Martínez‐Fleta, Petra, Gabrie, Ligia, Campo Guerola, Luciana del, Rodríguez-Frade, José Miguel, Casasnovas, José María, Reyburn, H. T., Valés-Gómez, Mar, López Trascasa, Margarita, Martín‐Gayo, Enrique, Calzada, María José, Castañeda, Santos, Fuente, Hortensia de la, González-Álvaro, Isidoro, Sánchez‐Madrid, Francisco, Muñoz‐Calleja, Cecilia, and Alfranca, Arántzazu

Abstract

SARS‐CoV‐2 infection causes an abrupt response by the host immune system, which is largely responsible for the outcome of COVID‐19. We investigated whether the specific immune responses in the peripheral blood of 276 patients associated to severity and progression of COVID‐19. At admission, dramatic lymphopenia of T, B and NK cells associated to severity. Conversely, the proportion of B cells, plasmablasts, circulating follicular helper T cells (cTfh) and CD56‐CD16+ NK‐cells increased. Regarding humoral immunity, levels of IgM, IgA and IgG were unaffected, but when degrees of severity were considered, IgG was lower in severe patients. Compared to healthy donors, complement C3 and C4 protein levels were higher in mild and moderate, but not in severe patients, while the activation peptide of C5 (C5a) increased from the admission in every patient, regardless their severity. Moreover, total IgG, the IgG1 and IgG3 isotypes and C4 decreased from day 0 to day 10 in patients who were hospitalized for more than two weeks, but not in patients who were discharged earlier. Our study provides important clues to understand the immune response observed in COVID‐19 patients, associating severity with an imbalanced humoral response and identifying new targets for therapeutic intervention.

Published
2020

13. Occurrence of SARS-CoV-2 viremia is associated with genetic variants of genes related to COVID-19 pathogenesis.

Author

Roy-Vallejo E, Fernández De Córdoba-Oñate S, Delgado-Wicke P, Triguero-Martínez A, Montes N, Carracedo-Rodríguez R, Zurita-Cruz N, Marcos-Jiménez A, Lamana A, Galván-Román JM, Villapalos García G, Zubiaur P, Ciudad M, Rabes L, Sanz M, Rodríguez C, Villa A, Rodríguez JÁ, Marcos C, Hernando J, Díaz-Fernández P, Abad F, de Los Santos I, Rodríguez Serrano DA, García-Vicuña R, Suárez Fernández C, P Gomariz R, Muñoz-Calleja C, Fernández-Ruiz E, González-Álvaro I, Cardeñoso L, Barrios A, Sanz J, Casado P, Gutiérrez Á, Bautista A, Hernández P, Ruiz Giménez N, Moyano B, Gil P, Jesús Delgado M, Parra P, Sánchez B, Sáez C, Fernández Rico M, Arévalo Román C, Castañeda S, Llorente I, G Tomero E, García Castañeda N, Uriarte M, Fontán García-Rodrigo L, Domingo García D, Alarcón Cavero T, Auxiliadora Semiglia Chong M, Gutiérrez Cobos A, Sánchez-Madrid F, Martín Gayo E, Sánchez-Cerrillo I, Martínez-Fleta P, López-Sanz C, Gabrie L, Del Campo Guerola L, Tejedor R, Ancochea J, García Castillo E, Ávalos E, Sánchez-Azofra A, Alonso T, Cisneros C, Valenzuela C, Javier García Pérez F, María Girón R, Aspa J, Marcos C, Del Perpetuo Socorro Churruca M, Zamora E, Martínez A, Barrio Mayo M, Henares Espi R, Méndez R, Arribas D, Chicot Llano M, González B, Quicios B, Patiño P, Trigueros M, Dominguez Peña C, Jiménez Jiménez D, Villamayor P, Canabal A, de la Cámara R, Ortiz J, and Iturrate I

Abstract

Introduction: SARS-CoV-2 viral load has been related to COVID-19 severity. The main aim of this study was to evaluate the relationship between SARS-CoV-2 viremia and SNPs in genes previously studied by our group as predictors of COVID-19 severity., Materials and Methods: Retrospective observational study including 340 patients hospitalized for COVID-19 in the University Hospital La Princesa between March 2020 and December 2021, with at least one viremia determination. Positive viremia was considered when viral load was above the quantifiable threshold (20 copies/ml). A total of 38 SNPs were genotyped. To study their association with viremia a multivariate logistic regression was performed., Results: The mean age of the studied population was 64.5 years (SD 16.6), 60.9% patients were male and 79.4% white non-Hispanic. Only 126 patients (37.1%) had at least one positive viremia. After adjustment by confounders, the presence of the minor alleles of rs2071746 ( HMOX1 ; T/T genotype OR 9.9 p  < 0.0001), rs78958998 (probably associated with SERPING1 expression; A/T genotype OR 2.3, p  = 0.04 and T/T genotype OR 12.9, p  < 0.0001), and rs713400 (eQTL for TMPRSS2 ; C/T + T/T genotype OR 1.86, p  = 0.10) were associated with higher risk of viremia, whereas the minor alleles of rs11052877 ( CD69 ; A/G genotype OR 0.5, p = 0.04 and G/G genotype OR 0.3, p  = 0.01), rs2660 ( OAS1 ; A/G genotype OR 0.6, p  = 0.08), rs896 ( VIPR1 ; T/T genotype OR 0.4, p  = 0.02) and rs33980500 ( TRAF3IP2 ; C/T + T/T genotype OR 0.3, p  = 0.01) were associated with lower risk of viremia., Conclusion: Genetic variants in HMOX1 (rs2071746), SERPING1 (rs78958998), TMPRSS2 (rs713400), CD69 (rs11052877), TRAF3IP2 (rs33980500), OAS1 (rs2660) and VIPR1 (rs896) could explain heterogeneity in SARS-CoV-2 viremia in our population., Competing Interests: FA, has been consultant or investigator in clinical trials sponsored by the following pharmaceutical companies: Abbott, Alter, Aptatargets, Chemo, FAES, Farmalíder, Ferrer, Galenicum, GlaxoSmithKline, Gilead, Italfarmaco, Janssen-Cilag, Kern, Normon, Novartis, Servier, Teva and Zambon. IG-Á reports grants from Instituto de Salud Carlos III, during the course of the study; personal fees from Lilly and Sanofi; personal fees and non-financial support from BMS; personal fees and non-financial support from Abbvie; research support, personal fees and non-financial support from Roche Laboratories; research support from Gebro Pharma; non-financial support from MSD, Pfizer and Novartis, not related to the submitted work. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Roy-Vallejo, Fernández de Córdoba-Oñate, Delgado-Wicke, Triguero-Martínez, Montes, Carracedo-Rodríguez, Zurita-Cruz, Marcos-Jiménez, Lamana, Galván-Román, Villapalos García, Zubiaur, Ciudad, Rabes, Sanz, Rodríguez, Villa, Rodríguez, Marcos, Hernando, Díaz-Fernández, Abad, de los Santos, Rodríguez Serrano, García-Vicuña, Suárez Fernández, P. Gomariz, Muñoz-Calleja, Fernández-Ruiz, González-Álvaro Cardeñoso and the PREDINMUN-COVID Group.)

Published
2023
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