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3. A prognostic model for tumor recurrence and progression after meningioma surgery: preselection for further molecular work-up

Author

Padevit, Luis, primary, Vasella, Flavio, additional, Friedman, Jason, additional, Mutschler, Valentino, additional, Jenkins, Freya, additional, Held, Ulrike, additional, Rushing, Elisabeth Jane, additional, Wirsching, Hans-Georg, additional, Weller, Michael, additional, Regli, Luca, additional, and Neidert, Marian Christoph, additional

Published
2023
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5. A Prognostic Model For Tumor Recurrence And Progression After Meningioma Surgery: Preselection For Further Molecular Work

Author

Padevit, Luis, primary, Vasella, Flavio, additional, Friedman, Jason, additional, Mutschler, Valentino, additional, Jenkins, Freya, additional, Held, Ulrike, additional, Rushing, Elisabeth Jane, additional, Wirsching, Hans-Georg, additional, Weller, Michael, additional, Regli, Luca, additional, and Neidert, Marian Christoph, additional

Published
2023
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6. Mutational Landscape and Expression of PD-L1 in Patients with Non-Small Cell Lung Cancer Harboring Genomic Alterations of the MET gene

Author

Fischer, Alessa, Bankel, Lorenz, Hiltbrunner, Stefanie, Rechsteiner, Markus, Rüschoff, Jan H, Rushing, Elisabeth Jane, Britschgi, Christian, Curioni-Fontecedro, Alessandra, University of Zurich, and Curioni-Fontecedro, Alessandra

Subjects
Proto-Oncogene Proteins B-raf, Cancer Research, Lung Neoplasms, DNA Copy Number Variations, 610 Medicine & health, Genomics, Proto-Oncogene Proteins c-met, B7-H1 Antigen, Proto-Oncogene Proteins p21(ras), Oncology, Carcinoma, Non-Small-Cell Lung, 10049 Institute of Pathology and Molecular Pathology, Mutation, 10032 Clinic for Oncology and Hematology, Humans, 2736 Pharmacology (medical), Pharmacology (medical), 2730 Oncology, 1306 Cancer Research
Abstract

Mesenchymal-to-epithelial transition (MET) exon 14 skipping mutations and MET gene amplification occur in 3-5% of non-small cell lung cancer (NSCLC) patients. Tyrosine kinase inhibitors (TKIs) targeting MET alterations have shown promising results in these patients.The aim of this study was to describe the genomic profile, PD-L1 expression and clinicopathological features of MET dysregulated NSCLC.We identified 188 patients with advanced-stage NSCLC with data on MET expression by immunohistochemistry (IHC). IHC for PD-L1 expression was performed in 131 patient samples, and next-generation sequencing (NGS) analysis was performed in 109 patient samples.MET exon 14 skipping alterations were identified in 16 (14.7%) samples, MET amplifications with cut-off ≥4 copy number variations were identified in 11 (10.1%) samples, and an oncogenic MET mutation (MET p.D1228N) was identified in 1 (0.9%) sample. 12/15 tumors (80.0%) harboring MET exon 14 alterations and 7/11 (63.6%) MET-amplified tumors expressed PD-L1 in ≥1% of tumor cells. Tumors harboring MET exon 14 skipping alterations expressed PD-L1 more frequently than MET wild-type IHC-positive tumors (p = 0.045). Twenty-five percent of MET exon 14-altered cases and 33% of MET-amplified cases harbored potentially targetable oncogenic co-mutations in KRAS, BRAF, and EGFR. The most frequent co-occurring mutations in all MET-altered tumors were TP53, KRAS, BRAF, and CDK4.We demonstrated that MET exon 14 skipping alterations and MET amplification are not mutually exclusive to other oncogenic co-mutations, and report the association of genomic MET alterations with PD-L1 expression. Since genomic MET alterations are emerging targets requiring upfront treatment, optimal understanding of the co-mutational landscape for this patient population is needed.

Published
2022

7. Anaplastic ganglioglioma-A diagnosis comprising several distinct tumour types

Author

Reinhardt, Annekathrin, Pfister, Kristin, Schrimpf, Daniel, et al, Gramatzki, Dorothee, Weller, Michael, Rushing, Elisabeth Jane, and University of Zurich

Subjects
2734 Pathology and Forensic Medicine, 2728 Neurology (clinical), 2737 Physiology (medical), 2808 Neurology, 610 Medicine & health, 2722 Histology, 10040 Clinic for Neurology
Published
2022

8. MEDB-04. Young children with metastatic medulloblastoma: frequent requirement for radiotherapy in children with non-WNT/non-SHH medulloblastoma despite highly intensified chemotherapy – Results of the MET-HIT2000-BIS4 trial

Author

Mynarek, Martin, primary, Goschzik, Tobias, additional, Kool, Marcel, additional, von Hoff, Katja, additional, Ottensmeier, Holger, additional, Warmuth-Metz, Monika, additional, Bison, Brigitte, additional, Sill, Martin, additional, Rushing, Elisabeth Jane, additional, Hasselblatt, Martin, additional, Koch, Arend, additional, Schüller, Ulrich, additional, von Deimling, Andreas, additional, Riemenschneider, Markus J, additional, Dohmen, Hildegard, additional, Monoranu, Camelia-Maria, additional, Sommer, Clemens, additional, Staszewski, Ori, additional, Mawrin, Christian, additional, Schittenhelm, Jens, additional, Brück, Wolfgang, additional, Filipski, Katharina, additional, Hartmann, Christian, additional, Meinhardt, Matthias, additional, Pietschmann, Klaus, additional, Haberler, Christine, additional, Slavc, Irene, additional, Gerber, Nicolas U, additional, Grotzer, Michael, additional, Benesch, Martin, additional, Schlegel, Paul-Gerhardt, additional, Deinlein, Frank, additional, Bode, Udo, additional, von Bueren, André O, additional, Friedrich, Carsten, additional, Obrecht, Denise, additional, Fleischhack, Gudrun, additional, Kwiecien, Robert, additional, Faldum, Andreas, additional, Kortmann, Rolf-Dieter, additional, Pietsch, Torsten, additional, Pfister, Stefan, additional, and Rutkowski, Stefan, additional

Published
2022
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13. MODL-22. DEVELOPING A REAL-TIME PERSONALIZED DRUG TESTING PLATFORM FOR PEDIATRIC CNS CANCERS

Author

Laternser, Sandra, primary, Cosentino, Chiara Cianciolo, additional, Przystal, Justyna M, additional, Dettwiler, Susanne, additional, Rushing, Elisabeth Jane, additional, Gerber, Nicolas U, additional, Stücklin, Ana Guerreiro, additional, Prasad, Rachna, additional, Grotzer, Michael, additional, Krayenbühl, Niklaus, additional, Müller, Sabine, additional, and Nazarian, Javad, additional

Published
2020
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14. MBCL-07. NON-METASTATIC MEDULLOBLASTOMA OF EARLY CHILDHOOD: RESULTS FROM THE PROSPECTIVE CLINICAL TRIAL HIT-2000 AND AN EXTENDED VALIDATION COHORT

Author

Mynarek, Martin, primary, von Hoff, Katja, additional, Pietsch, Torsten, additional, Ottensmeier, Holger, additional, Warmuth-Metz, Monika, additional, Bison, Brigitte, additional, Pfister, Stefan, additional, Korshunov, Andrey, additional, Sharma, Tanvi, additional, Jaeger, Natalie, additional, Ryzhova, Marina, additional, Zheludkova, Olga, additional, Golanov, Andrey, additional, Rushing, Elisabeth Jane, additional, Hasselblatt, Martin, additional, Koch, Arend, additional, Schüller, Ulrich, additional, von Deimling, Andreas, additional, Sahm, Felix, additional, Sill, Martin, additional, Riemenschneider, Markus J, additional, Dohmen, Hildegard, additional, Monoranu, Camelia-Maria, additional, Sommer, Clemens, additional, Staszewski, Ori, additional, Mawrin, Christian, additional, Schittenhelm, Jens, additional, Brück, Wolfgang, additional, Filipski, Katharina, additional, Hartmann, Christian, additional, Meinhardt, Matthias, additional, Pietschmann, Klaus, additional, Haberler, Christine, additional, Slavc, Irene, additional, Gerber, Nicolas U, additional, Grotzer, Michael, additional, Benesch, Martin, additional, Schlegel, Paul-Gerhardt, additional, Deinlein, Frank, additional, von Bueren, André O, additional, Friedrich, Carsten, additional, Obrecht, Denise, additional, Fleischhack, Gudrun, additional, Kwiecien, Robert, additional, Faldum, Andreas, additional, Kortmann, Rolf-Dieter, additional, Kool, Marcel, additional, and Rutkowski, Stefan, additional

Published
2020
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16. Single-Cell Mapping of Human Brain Cancer Reveals Tumor-Specific Instruction of Tissue-Invading Leukocytes

Author

Friebel, Ekaterina, primary, Kapolou, Konstantina, additional, Unger, Susanne, additional, Núñez, Nicolás Gonzalo, additional, Utz, Sebastian, additional, Rushing, Elisabeth Jane, additional, Regli, Luca, additional, Weller, Michael, additional, Greter, Melanie, additional, Tugues, Sonia, additional, Neidert, Marian Christoph, additional, and Becher, Burkhard, additional

Published
2020
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18. ACTR-05. THE RANDOMIZED PHASE II ARTE TRIAL: BEVACIZUMAB PLUS HYPOFRACTIONATED RADIOTHERAPY VERSUS RADIOTHERAPY ALONE IN ELDERLY PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA

Author

Weller, Michael, primary, Tabatabai, Ghazaleh, additional, Roelcke, Ulrich, additional, Hottinger, Andreas, additional, Joerger, Francisca, additional, Schmid, Andrea, additional, Plasswilm, Ludwig, additional, Schrimpf, Daniel, additional, Mancao, Christoph, additional, Capper, David, additional, Conen, Katrin, additional, Hundsberger, Thomas, additional, Caparrotti, Francesca, additional, von Moos, Roger, additional, Riklin, Christian, additional, Felsberg, Jörg, additional, Roth, Patrick, additional, Jones, David, additional, Pfister, Stefan M, additional, Rushing, Elisabeth Jane, additional, Abrey, Lauren, additional, Reifenberger, Guido, additional, Held, Leonhard, additional, von Deimling, Andreas, additional, Ochsenbein, Adrian, additional, and Wirsching, Hans-Georg, additional

Published
2017
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19. MNGI-02. PREOPERATIVE EMBOLIZATION OF MENINGIOMA: INFERIOR NEUROLOGICAL OUTCOME, INCREASED RISK OF CARDIOVASCULAR COMPLICATIONS AND SHORTER TIME TO RECURRENCE?

Author

Wirsching, Hans-Georg, primary, Richter, Johannes Konstantin, additional, Sahm, Felix, additional, Morel, Corinne, additional, Krayenbuehl, Niklaus, additional, Rushing, Elisabeth Jane, additional, von Deimling, Andreas, additional, Valavanis, Antonios, additional, and Weller, Michael, additional

Published
2017
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20. CMET-26. DIAGNOSTIC VALUE OF FDG-PET/CT FOR PATIENTS WITH BRAIN METASTASIS FROM UNKNOWN PRIMARY SITE

Author

Wolpert, Fabian, primary, Weller, Michael, additional, Berghoff, Anna Sophie, additional, Rushing, Elisabeth Jane, additional, Füreder, Lisa Michaela, additional, Petyt, Gregory, additional, Leske, Henning, additional, Andratschke, Nicolaus, additional, Regli, Luca, additional, Neidert, Marian Christoph, additional, Stupp, Roger, additional, Stahel, Rolf, additional, Dummer, Reinhard, additional, Frauenfelder, Thomas, additional, Roth, Patrick, additional, Reyns, Nicolas, additional, Kaufmann, Philipp Antonio, additional, and Rhun, Emilie Le, additional

Published
2017
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21. Protease resistance of infectious prions is suppressed by removal of a single atom in the cellular prion protein

Author

Leske, Henning, primary, Hornemann, Simone, additional, Herrmann, Uli Simon, additional, Zhu, Caihong, additional, Dametto, Paolo, additional, Li, Bei, additional, Laferriere, Florent, additional, Polymenidou, Magdalini, additional, Pelczar, Pawel, additional, Reimann, Regina Rose, additional, Schwarz, Petra, additional, Rushing, Elisabeth Jane, additional, Wüthrich, Kurt, additional, and Aguzzi, Adriano, additional

Published
2017
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24. Predicting outcome of epilepsy after meningioma resection

Author

Wirsching, Hans-Georg, primary, Morel, Corinne, additional, Gmür, Corinne, additional, Neidert, Marian Christoph, additional, Baumann, Christian Richard, additional, Valavanis, Antonios, additional, Rushing, Elisabeth Jane, additional, Krayenbühl, Niklaus, additional, and Weller, Michael, additional

Published
2015
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25. Soluble alpha-Klotho: A novel serum biomarker for the activity of growth hormone producing pituitary adenomas

Author

Neidert, Marian Christoph, Sze, Lisa, Zwimpfer, Cornelia, Sarnthein, Johannes, Seifert, Burkhardt, Frei, Karl, Leske, Henning, Rushing, Elisabeth Jane, Schmid, Christoph, Bernays, Rene, University of Zurich, and Neidert, Marian Christoph

Subjects
10208 Institute of Neuropathology, 10265 Clinic for Endocrinology and Diabetology, 610 Medicine & health, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI), 610 Medical sciences, Medicine, urologic and male genital diseases, pituitary, female genital diseases and pregnancy complications, Klotho, 1310 Endocrinology, 10180 Clinic for Neurosurgery, 2712 Endocrinology, Diabetes and Metabolism, ddc: 610, 570 Life sciences, biology, acromegaly
Abstract

Objective: Klotho is a lifespan-influencing gene expressed in the kidneys and other tissues, including the pituitary gland. Soluble alpha-Klotho (alpha-KL) is released into the circulation. The aim of this prospective controlled study is to present baseline serum levels of alpha-KL in patients with [for full text, please go to the a.m. URL], 64. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Published
2013

28. Non-metastatic medulloblastoma of early childhood : results from the prospective clinical trail HIT-2000 and an extended validation cohort

Author

Mynarek, Martin, von Hoff, Katja, Pietsch, Torsten, Ottensmeier, Holger, Warmuth-Metz, Monika, Bison, Brigitte, Pfister, Stefan, Korshunov, Andrey, Sharma, Tanvi, Jaeger, Natalie, Ryzhova, Marina, Zheludkova, Olga, Golanov, Andrey, Rushing, Elisabeth Jane, Hasselblatt, Martin, Koch, Arend, Schüller, Ulrich, von Deimling, Andreas, Sahm, Felix, Sill, Martin, Riemenschneider, Markus J, Dohmen, Hildegard, Monoranu, Camelia-Maria, Sommer, Clemens, Staszewski, Ori, Mawrin, Christian, Schittenhelm, Jens, Brück, Wolfgang, Filipski, Katharina, Hartmann, Christian, Meinhardt, Matthias, Pietschmann, Klaus, Haberler, Christine, Slavc, Irene, Gerber, Nicolas U, Grotzer, Michael, Benesch, Martin, Schlegel, Paul-Gerhardt, Deinlein, Frank, von Bueren, André O, Friedrich, Carsten, Obrecht, Denise, Fleischhack, Gudrun, Kwiecien, Robert, Faldum, Andreas, Kortmann, Rolf-Dieter, Kool, Marcel, and Rutkowski, Stefan

Subjects
Medizin
Published
2000

30. Predicting outcome of epilepsy after meningioma resection.

Author

Wirsching HG, Morel C, Gmür C, Neidert MC, Baumann CR, Valavanis A, Rushing EJ, Krayenbühl N, and Weller M

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Anticonvulsants therapeutic use, Electroencephalography methods, Epilepsy physiopathology, Female, Humans, Male, Meningeal Neoplasms diagnosis, Meningioma diagnosis, Middle Aged, Postoperative Period, Retrospective Studies, Seizures etiology, Treatment Outcome, Young Adult, Epilepsy etiology, Meningeal Neoplasms complications, Meningeal Neoplasms surgery, Meningioma complications, Meningioma surgery
Abstract

Background: Surgical excision is the standard treatment for intracranial meningiomas. Epilepsy is a major cause of morbidity in meningioma patients, but postoperative control of epilepsy is not achieved in a substantial fraction of patients. The purpose of this study was to define risk factors for postoperative epilepsy., Methods: Patients treated for histologically confirmed intracranial meningioma at the University Hospital Zurich between 2000 and 2013 were retrospectively analyzed. Demographic, clinical, imaging, and electroencephalographic data were assessed. A binary regression model was applied to identify risk factors for postoperative epilepsy., Results: Of the 779 patients analyzed, epileptic seizures occurred in 244 (31.3%) patients before surgery and in 204 (26.6%) patients after surgery. Of the 244 patients with preoperative epilepsy, 144 (59.0%) became seizure-free after surgery; of the 535 patients without preoperative seizures, 104 (19.4%) suffered from epilepsy after surgery. Risk factors for postoperative epilepsy were preoperative epilepsy (odds ratio [OR]: 3.46 [95% confidence interval {CI}: 2.32-5.16]), major surgical complications including CNS infections (OR: 5.89 [95% CI: 1.53-22.61]), hydrocephalus (OR: 3.27 [95% CI: 1.35-7.95]), recraniotomy (OR: 2.91 [95% CI: 1.25-6.78]), and symptomatic intracranial hemorrhage (OR: 2.60 [95% CI: 1.17-5.76]) as well as epileptiform EEG potentials (OR: 2.52 [95% CI: 1.36-4.67]), younger age (OR: 1.74 [(95% CI: 1.18-2.58]), and tumor progression (OR: 1.92 [95% CI: 1.16-3.18]). Postoperative improvement or recovery from preoperative neurologic deficits was associated with improved seizure control (OR: 0.46 [95% CI: 0.25-0.85], P = .013)., Conclusion: We suggest prospective validation of a score ("STAMPE2") based on clinical findings, EEG, and brain-imaging measures to estimate postoperative seizure risk and guide anticonvulsant treatment in meningioma patients., (© The Author(s) 2015. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

Published
2016
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