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1. Mild sonochemical exfoliation of bromine-intercalated graphite: a new route towards graphene

Author

Widenkvist, E., Boukhvalov, D. W., Rubino, S., Akhtar, S., Lu, J., Quinlan, R. A., Katsnelson, M. I., Leifer, K., Grennberg, H., and Jansson, U.

Subjects
Condensed Matter - Materials Science
Abstract

A method to produce suspensions of graphene sheets by combining solution-based bromine intercalation and mild sonochemical exfoliation is presented. Ultrasonic treatment of graphite in water leads to the formation of suspensions of graphite flakes. The delamination is dramatically improved by intercalation of bromine into the graphite before sonication. The bromine intercalation was verified by Raman spectroscopy as well as by x-ray photoelectron spectroscopy (XPS), and density functional theory (DFT) calculations show an almost ten times lower interlayer binding energy after introducing Br2 into the graphite. Analysis of the suspended material by transmission and scanning electron microscopy (TEM and SEM) revealed a significant content of few-layer graphene with sizes up to 30 $mu$m, corresponding to the grain size of the starting material., Comment: 10 pages 4 figures

Published
2009
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4. ERAS program adherence-institutionalization, major morbidity and anastomotic leakage after elective colorectal surgery: the iCral2 multicenter prospective study

Author

Catarci, M, Ruffo, G, Viola, M, Pirozzi, F, Delrio, P, Borghi, F, Garulli, G, Baldazzi, G, Marini, P, Sica, G, Guercioni, G, Ciano, P, Benedetti, M, Cicconi, S, Marziali, I, Bertocchi, E, Altamura, A, Rubichi, F, Sciuto, A, Pace, U, Fares Bucci, A, Cianflocca, D, Migliore, M, Pirrera, B, Alagna, V, Cassini, D, Attinà, G, Arcudi, C, Sensi, B, Bucci, A, Campagnacci, R, Maurizi, A, Basti, M, Frazzini, D, Caracino, V, Pedrazzani, C, Turri, G, Mancini, S, Sagnotta, A, Scatizzi, M, Pandolfini, L, Falsetto, A, Baiocchi, G, Molfino, S, Totis, M, Braga, M, Liverani, A, Cesare, T, Scabini, S, Martino, A, Luca, R, Simone, M, Carrara, A, Tirone, G, Motter, M, Caricato, M, Capolupo, G, Amodio, P, Palmieri, R, Pavanello, M, Marco, C, Muratore, A, Marsanic, P, Patriti, A, Sisti, V, Lucchi, A, Martorelli, G, Clementi, M, Guadagni, S, Longo, G, Tomassini, F, Santoni, S, Vettoretto, N, Botteri, E, Armellini, A, Brisinda, G, Chiarello, M, Cariati, M, Berti, S, Gennai, A, Anania, G, Rubino, S, Siquini, W, Cardinali, A, Catarci M., Ruffo G., Viola M. G., Pirozzi F., Delrio P., Borghi F., Garulli G., Baldazzi G., Marini P., Sica G., Guercioni G., Ciano P., Benedetti M., Cicconi S., Marziali I., Bertocchi E., Altamura A., Rubichi F., Sciuto A., Pace U., Fares Bucci A., Cianflocca D., Migliore M., Pirrera B., Alagna V., Cassini D., Attinà G. M., Arcudi C., Sensi B., Bucci A. F., Campagnacci R., Maurizi A., Basti M., Frazzini D., Caracino V., Pedrazzani C., Turri G., Mancini S., Sagnotta A., Scatizzi M., Pandolfini L., Falsetto A., Baiocchi G. L., Molfino S., Totis M., Braga M., Liverani A., Cesare T. D., Scabini S., Martino A., Luca R. D., Simone M., Carrara A., Tirone G., Motter M., Caricato M., Capolupo G. T., Amodio P., Palmieri R. M., Pavanello M., Marco C. D., Muratore A., Marsanic P., Patriti A., Sisti V., Lucchi A., Martorelli G., Clementi M., Guadagni S., Longo G., Tomassini F., Santoni S., Vettoretto N., Botteri E., Armellini A., Brisinda G., Chiarello M. M., Cariati M., Berti S., Gennai A., Anania G., Rubino S., Siquini W., Cardinali A., Catarci, M, Ruffo, G, Viola, M, Pirozzi, F, Delrio, P, Borghi, F, Garulli, G, Baldazzi, G, Marini, P, Sica, G, Guercioni, G, Ciano, P, Benedetti, M, Cicconi, S, Marziali, I, Bertocchi, E, Altamura, A, Rubichi, F, Sciuto, A, Pace, U, Fares Bucci, A, Cianflocca, D, Migliore, M, Pirrera, B, Alagna, V, Cassini, D, Attinà, G, Arcudi, C, Sensi, B, Bucci, A, Campagnacci, R, Maurizi, A, Basti, M, Frazzini, D, Caracino, V, Pedrazzani, C, Turri, G, Mancini, S, Sagnotta, A, Scatizzi, M, Pandolfini, L, Falsetto, A, Baiocchi, G, Molfino, S, Totis, M, Braga, M, Liverani, A, Cesare, T, Scabini, S, Martino, A, Luca, R, Simone, M, Carrara, A, Tirone, G, Motter, M, Caricato, M, Capolupo, G, Amodio, P, Palmieri, R, Pavanello, M, Marco, C, Muratore, A, Marsanic, P, Patriti, A, Sisti, V, Lucchi, A, Martorelli, G, Clementi, M, Guadagni, S, Longo, G, Tomassini, F, Santoni, S, Vettoretto, N, Botteri, E, Armellini, A, Brisinda, G, Chiarello, M, Cariati, M, Berti, S, Gennai, A, Anania, G, Rubino, S, Siquini, W, Cardinali, A, Catarci M., Ruffo G., Viola M. G., Pirozzi F., Delrio P., Borghi F., Garulli G., Baldazzi G., Marini P., Sica G., Guercioni G., Ciano P., Benedetti M., Cicconi S., Marziali I., Bertocchi E., Altamura A., Rubichi F., Sciuto A., Pace U., Fares Bucci A., Cianflocca D., Migliore M., Pirrera B., Alagna V., Cassini D., Attinà G. M., Arcudi C., Sensi B., Bucci A. F., Campagnacci R., Maurizi A., Basti M., Frazzini D., Caracino V., Pedrazzani C., Turri G., Mancini S., Sagnotta A., Scatizzi M., Pandolfini L., Falsetto A., Baiocchi G. L., Molfino S., Totis M., Braga M., Liverani A., Cesare T. D., Scabini S., Martino A., Luca R. D., Simone M., Carrara A., Tirone G., Motter M., Caricato M., Capolupo G. T., Amodio P., Palmieri R. M., Pavanello M., Marco C. D., Muratore A., Marsanic P., Patriti A., Sisti V., Lucchi A., Martorelli G., Clementi M., Guadagni S., Longo G., Tomassini F., Santoni S., Vettoretto N., Botteri E., Armellini A., Brisinda G., Chiarello M. M., Cariati M., Berti S., Gennai A., Anania G., Rubino S., Siquini W., and Cardinali A.

Abstract

Background: Enhanced recovery after surgery (ERAS) programs influence morbidity rates and length of stay after colorectal surgery (CRS), and may also impact major complications and anastomotic leakage rates. A prospective multicenter observational study to investigate the interactions between ERAS program adherence and early outcomes after elective CRS was carried out. Methods: Prospective enrolment of patients submitted to elective CRS with anastomosis in 18 months. Adherence to 21 items of ERAS program was measured upon explicit criteria in every case. After univariate analysis, independent predictors of primary endpoints [major morbidity (MM) and anastomotic leakage (AL) rates] were identified through logistic regression analyses including all significant variables, presenting odds ratios (OR). Results: Institutional ERAS protocol was declared by 27 out of 38 (71.0%) participating centers. Median overall adherence to ERAS program items was 71.4%. Among 3830 patients included in the study, MM and AL rates were 4.7% and 4.2%, respectively. MM rates were independently influenced by intra- and/or postoperative blood transfusions (OR 7.79, 95% CI 5.46–11.10; p < 0.0001) and standard anesthesia protocol (OR 0.68, 95% CI 0.48–0.96; p = 0.028). AL rates were independently influenced by male gender (OR 1.48, 95% CI 1.06–2.07; p = 0.021), intra- and/or postoperative blood transfusions (OR 4.29, 95% CI 2.93–6.50; p < 0.0001) and non-standard resections (OR 1.49, 95% CI 1.01–2.22; p = 0.049). Conclusions: This study disclosed wide room for improvement in compliance to several ERAS program items. It failed to detect any significant association between institutionalization and/or adherence rates to ERAS program with primary endpoints. These outcomes were independently influenced by gender, intra- and postoperative blood transfusions, non-standard resections, and standard anesthesia protocol.

Published
2022

6. Italy's health performance, 1990–2017: findings from the Global Burden of Disease Study 2017

Author

Monasta, L, Abbafati, C, Logroscino, G, Remuzzi, G, Perico, N, Bikbov, B, Tamburlini, G, Beghi, E, Traini, E, Boston Redford, S, Ariani, F, Borzì, AM, Bosetti, C, Carreras, G, Caso, V, Castelpietra, G, Cirillo, Massimo, Conti, S, Cortesi, PA, Damiani, G, D’Angiolella, LS, Fanzo, J, Farioli, A, Fornari, C, Gallus, S, Giussani, G, Gorini, G, Grosso, G, Guido, D, La Vecchia, C, Lauriola, P, Leonardi, M, Levi, M, Madotto, F, Mondello, S, Naldi, L, Olgiati, S, Palladino, Raffaele, Piccinelli, C, Piccininni, M, Pupillo, P, Raggi, A, Rubino, S, Santalucia, P, Vacante, M, Vidale, S, Violante, FS, Naghavi, M, and Ronfani, Monasta, L, Abbafati, C, Logroscino, G, Remuzzi, G, Perico, N, Bikbov, B, Tamburlini, G, Beghi, E, Traini, E, Boston Redford, S, Ariani, F, Borzì, Am, Bosetti, C, Carreras, G, Caso, V, Castelpietra, G, Cirillo, Massimo, Conti, S, Cortesi, Pa, Damiani, G, D’Angiolella, L, Fanzo, J, Farioli, A, Fornari, C, Gallus, S, Giussani, G, Gorini, G, Grosso, G, Guido, D, La, Vecchia, Lauriola, P, Leonardi, M, Levi, M, Madotto, F, Mondello, S, Naldi, L, Olgiati, S, Palladino, Raffaele, Piccinelli, C, Piccininni, M, Pupillo, P, Raggi, A, Rubino, S, Santalucia, P, Vacante, M, Vidale, S, Violante, F, Naghavi, M, And, Ronfani, GBD 2017 Italy Collaborators, Andrea Farioli, Francesco S. Violante, Monasta, L., Abbafati, C., Logroscino, G., Remuzzi, G., Perico, N., Bikbov, B., Tamburlini, G., Beghi, E., Traini, E., Redford, S. B., Ariani, F., Borzi, A. M., Bosetti, C., Carreras, G., Caso, V., Castelpietra, G., Cirillo, M., Conti, S., Cortesi, P. A., Damiani, G., D'Angiolella, L. S., Fanzo, J., Fornari, C., Gallus, S., Giussani, G., Gorini, G., Grosso, G., Guido, D., La Vecchia, C., Lauriola, P., Leonardi, M., Levi, M., Madotto, F., Mondello, S., Naldi, L., Olgiati, S., Palladino, R., Piccinelli, C., Piccininni, M., Pupillo, E., Raggi, A., Rubino, S., Santalucia, P., Vacante, M., Vidale, S., Violante, F. S., Naghavi, M., Ronfani, L., Redford, S, Borzì, A, Cirillo, M, Cortesi, P, D'Angiolella, L, La Vecchia, C, Palladino, R, Pupillo, E, and Ronfani, L

Subjects
Male, GBD 2017 Italy Collaborators, Health Status, Demographic transition, Disease, Global Health, 01 natural sciences, Global Burden of Disease, Health Statu, 0302 clinical medicine, Universal Health Insurance, Cause of Death, Health care, Medicine, 030212 general & internal medicine, Public, Environmental & Occupational Health, global burden of disease, Italy, health performance, health-care system, lcsh:Public aspects of medicine, Mortality rate, 1. No poverty, Italian health loss, 3. Good health, Female, TERRITORIES, Life Sciences & Biomedicine, Human, Population ageing, medicine.medical_specialty, Cost Control, Waiting Lists, GBD, 195 COUNTRIES, World Health Organization, Article, 03 medical and health sciences, Life Expectancy, SYSTEMATIC ANALYSIS, Delivery of Health Care, Humans, 0101 mathematics, Science & Technology, SEX-SPECIFIC MORTALITY, health care system, business.industry, DISABILITY, Public health, 010102 general mathematics, Public Health, Environmental and Occupational Health, lcsh:RA1-1270, xxx, Years of potential life lost, Life expectancy, INJURIES, GBD Italy, business, Demography
Abstract

Summary Background Through a comprehensive analysis of Italy's estimates from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017, we aimed to understand the patterns of health loss and response of the health-care system, and offer evidence-based policy indications in light of the demographic transition and government health spending in the country. Methods Estimates for Italy were extracted from GBD 2017. Data on Italy are presented for 1990 and 2017, on prevalence, causes of death, years of life lost, years lived with disability, disability-adjusted life-years (DALYs), life expectancy at birth and at age 65 years, healthy life expectancy, and Healthcare Access and Quality (HAQ) Index. We compared the estimates for Italy with those of 15 other western European countries. Findings The quality of the universal health system and healthy behaviours contribute to favourable overall health, even in comparison with other western European countries. In 2017, life expectancy and HAQ Index score in Italy were among the highest globally, with life expectancy at birth reaching 85·3 years for females and 80·8 for males in 2017, ranking Italy eighth globally for females and sixth for males, and an HAQ Index score of 94·9 in 2016 compared with 81·54 in 1990, keeping Italy ranked as ninth globally. Between 1990 and 2017 age-standardised death rates for cardiovascular diseases decreased by 53·7% (95% uncertainty interval −56·1 to −51·4), for neoplasms decreased by 28·2% (−32·3 to −24·6), and for transport injuries decreased by 62·1% (−64·6 to −59·2). However, population ageing is causing an increase in the burden of specific diseases, such as Alzheimer's disease and other dementias (DALYs increased by 77·9% [68·4 to 87·2]) and pancreatic (DALYs increased by 39·7% [28·4 to 51·7]) and uterine cancers (DALYs increased by 164·7% [129·7 to 202·5]). Behavioural risk factors, which are potentially modifiable, still have a strong effect, particularly on cardiovascular diseases and neoplasms. For instance, in 2017, 44 400 (41 200 to 47 800) cancer deaths were attributed to smoking, 12 000 (9600 to 14 800) to alcohol use, and 9500 (5400 to 14 200) to high body-mass index, while 47 000 (31 100 to 65 700) deaths due to cardiovascular diseases could be attributed to high LDL cholesterol, 28 700 (19 700 to 38 500) to diets low in whole grains, and 15 900 (8500 to 24 900) to low physical activity. Interpretation Italy provides an interesting example of the results that can be achieved by a mix of relatively healthy lifestyles and a universal health system. Two main issues require attention, population ageing and gradual decrease of public health financing, which both pose several challenges to the future of Italy's health status. Our findings should be useful to Italy's policy makers and health system experts elsewhere. Funding Bill & Melinda Gates Foundation.

Published
2019

10. DIAGNOSTIC ACCURACY OF IXIP INDEX AND PROSTATE MRI IN THE DIAGNOSIS OF PROSTATE CANCER: PRELIMINARY RESULTS ON A COMBINED APPROACH

Author

Cutaia G., Cannella R., Coraci G., Vernuccio F., Purpura P., Leto C., Rubino S., Calamia M., Raitano E., Salvaggio L., Tona G. L., Midiri M., Salvaggio G., Cutaia G., Cannella R., Coraci G., Vernuccio F., Purpura P., Leto C., Rubino S., Calamia M., Raitano E., Salvaggio L., Tona G.L., Midiri M., and Salvaggio G.

Subjects
Prostate cancer, Multiparametric Magnetic Resonance Imaging, Prostate-Specific Antigen, iXip, Settore MED/36 - Diagnostica Per Immagini E Radioterapia
Abstract

The purpose of this study was to assess whether Immune CompleX Predictive Index (iXip) improves diagnostic accuracy of multiparametric prostate MRI (mpMRI) for clinically significant prostate cancer. This study included 72 patients (mean age: 68±8 years) with suspicion of prostate cancer and available iXip score. mpMRI images were evaluated by two radiologists according to the PI-RADS v2.1. Reference standard was based on fusion biopsy and standard transperineal 12-point biopsy. Diagnostic accuracy of iXip, mpMRI and their combination were calculated. Optimal cutoff of iXip with sensitivity and specificity was identified using the Youden index. Patients with clinically significant prostate cancers had significantly higher iXip values compared to patients without clinically significant prostate cancers (median 0.411 vs 0.273; p=0.026). The AUROC for iXip was 0.795 (95% CI 0.579-1.000, p=0.026). Sensitivity and specificity were 75% and 100% respectively for mpMRI alone, and 100% and 80% respectively for mpMRI combined with iXip > 0.375. The combination of mpMRI with a cutoff value of iXip > 0.375 has a very high sensitivity for the diagnosis of prostate cancer and a moderately high specificity.

Published
2021

11. Laparoscopic right hemicolectomy: the SICE (Società Italiana di Chirurgia Endoscopica e Nuove Tecnologie) network prospective trial on 1225 cases comparing intra corporeal versus extra corporeal ileo-colic side-to-side anastomosis

Author

Anania G., Agresta F., Artioli E., Rubino S., Resta G., Vettoretto N., Petz W. L., Bergamini C., Arezzo A., Valpiani G., Morotti C., Silecchia G., Adamo V., Agrusa A., Alemanno G., Allaix M. E., Alo A., Altamura A., Ambrosi A., Antoniutti M., Apa D., Arcuri G., Baiocchi G. L., Balani A., Baldazzi G., Basti M., Benvenuto C., Berti S., Boni L., Borghi F., Botteri E., Brachet Contul R., Brescia A., Budassi A., Cafagna L., Calgaro M., Calo P. G., Campagnacci R., Canova G., Canu G. L., Caracino V., Carcoforo P., Carlini M., Casali L., Cassetti D., Cassinotti E., Catarci M., Cesari M., Checcacci P., Ciano P., Clementi M., Cocorullo G., Colombo F., Concone G., Contine A., Coppola M., Coratti A., Corcione F., Corleone P., Covotta L., Cuccurullo D., Cumbo P., D'ambrosio G., De Angelis F., De Luca M., De Manzini N., De Nisco C., De Palma G. D., De Paolis P., Degiuli M., Delogu D., Delrio P., Deserra A., Donini A., Elmore U., Ercolani G., Erdas E., Fabris L., Ferrari G., Feo G., Fidanza F., Foschi D., Galleano R., Garulli G., Gatti F., Gattolin A., Gelati S., Gelmini R., Ghazouani O., Gioffre A., Gobbi S., Grammatico V., Guariniello A., Giannessi S., Guerrieri M., Guerriero L., Gullotta G., Impellizzeri H., Izzo M., Jovine E., Lezoche G., Lirusso C., Lombardi R., Longoni M., Lucchi A., Luzzi A. P., Marini P., Marrosu A. G., Martino A., Mazza R., Mazzoccato S., Medas F., Meloni A., Milone M., Minciotti E., Monari F., Moretto G., Muttillo I. A., Navarra G., Neri S., Oldani A., Olmi S., Opocher E., Osenda E., Ottonello R., Panebianco V., Pavanello M., Pecchini F., Pellegrino L., Pennisi D., Perrotta N., Pertile D., Petri R., Picchetto A., Piccoli M., Pirrera B., Pisani Ceretti A., Pisano M., Podda M., Portolani N., Presenti L., Puzziello A., Razzi S., Rega D., Restini E., Ricci G., Rigamonti M., Rivolta U., Robustelli V., Romairone E., Rosati R., Rosso E., Roviello F., Sala S., Santarelli M., Sarro G., Sartori A., Scabini S., Scognamillo F., Sechi R., Solaini L., Soliani G., Soliani P., Soligo E., Sorrentino M., Spinoglio G., Stratta E., Taddei A., Talamo G., Targa S., Tartaglia N., Testa S., Ubiali P., Valeri A., Vasta F., Verzelli A., Vicentini R., Viola G., Violi V., Zago M., Zampino L., Anania, G., Agresta, F., Artioli, E., Rubino, S., Resta, G., Vettoretto, N., Petz, W. L., Bergamini, C., Arezzo, A., Valpiani, G., Morotti, C., Silecchia, G., Adamo, V., Agrusa, A., Alemanno, G., Allaix, M. E., Alo, A., Altamura, A., Ambrosi, A., Antoniutti, M., Apa, D., Arcuri, G., Baiocchi, G. L., Balani, A., Baldazzi, G., Basti, M., Benvenuto, C., Berti, S., Boni, L., Borghi, F., Botteri, E., Brachet Contul, R., Brescia, A., Budassi, A., Cafagna, L., Calgaro, M., Calo, P. G., Campagnacci, R., Canova, G., Canu, G. L., Caracino, V., Carcoforo, P., Carlini, M., Casali, L., Cassetti, D., Cassinotti, E., Catarci, M., Cesari, M., Checcacci, P., Ciano, P., Clementi, M., Cocorullo, G., Colombo, F., Concone, G., Contine, A., Coppola, M., Coratti, A., Corcione, F., Corleone, P., Covotta, L., Cuccurullo, D., Cumbo, P., D'Ambrosio, G., De Angelis, F., De Luca, M., De Manzini, N., De Nisco, C., De Palma, G. D., De Paolis, P., Degiuli, M., Delogu, D., Delrio, P., Deserra, A., Donini, A., Elmore, U., Ercolani, G., Erdas, E., Fabris, L., Ferrari, G., Feo, G., Fidanza, F., Foschi, D., Galleano, R., Garulli, G., Gatti, F., Gattolin, A., Gelati, S., Gelmini, R., Ghazouani, O., Gioffre, A., Gobbi, S., Grammatico, V., Guariniello, A., Giannessi, S., Guerrieri, M., Guerriero, L., Gullotta, G., Impellizzeri, H., Izzo, M., Jovine, E., Lezoche, G., Lirusso, C., Lombardi, R., Longoni, M., Lucchi, A., Luzzi, A. P., Marini, P., Marrosu, A. G., Martino, A., Mazza, R., Mazzoccato, S., Medas, F., Meloni, A., Milone, M., Minciotti, E., Monari, F., Moretto, G., Muttillo, I. A., Navarra, G., Neri, S., Oldani, A., Olmi, S., Opocher, E., Osenda, E., Ottonello, R., Panebianco, V., Pavanello, M., Pecchini, F., Pellegrino, L., Pennisi, D., Perrotta, N., Pertile, D., Petri, R., Picchetto, A., Piccoli, M., Pirrera, B., Pisani Ceretti, A., Pisano, M., Podda, M., Portolani, N., Presenti, L., Puzziello, A., Razzi, S., Rega, D., Restini, E., Ricci, G., Rigamonti, M., Rivolta, U., Robustelli, V., Romairone, E., Rosati, R., Rosso, E., Roviello, F., Sala, S., Santarelli, M., Sarro, G., Sartori, A., Scabini, S., Scognamillo, F., Sechi, R., Solaini, L., Soliani, G., Soliani, P., Soligo, E., Sorrentino, M., Spinoglio, G., Stratta, E., Taddei, A., Talamo, G., Targa, S., Tartaglia, N., Testa, S., Ubiali, P., Valeri, A., Vasta, F., Verzelli, A., Vicentini, R., Viola, G., Violi, V., Zago, M., Zampino, L., Anania G., Agresta F., Artioli E., Rubino S., Resta G., Vettoretto N., Petz W.L., Bergamini C., Arezzo A., Valpiani G., Morotti C., Silecchia G, and Adamo V, Agrusa A, Alemanno G, Allaix ME, Alò A, Altamura A, Ambrosi A, Antoniutti M, Apa D, Arcuri G, Baiocchi GL, Balani A, Baldazzi G, Basti M, Benvenuto C, Berti S, Boni L, Borghi F, Botteri E, Brachet Contul R, Brescia A, Budassi A, Cafagna L, Calgaro M, Calò PG, Campagnacci R, Canova G, Canu GL, Caracino V, Carcoforo P, Carlini M, Casali L, Cassetti D, Cassinotti E, Catarci M, Cesari M, Checcacci P, Ciano P, Clementi M, Cocorullo G, Colombo F, Concone G, Contine A, Coppola M, Coratti A, Corcione F, Corleone P, Covotta L, Cuccurullo D, Cumbo P, D'Ambrosio G, De Angelis F, De Luca M, De Manzini N, De Nisco C, De Palma GD, De Paolis P, Degiuli M, Delogu D, Delrio P, Deserra A, Donini A, Elmore U, Ercolani G, Erdas E, Fabris L, Ferrari G, Feo C, Fidanza F, Foschi D, Galleano R, Garulli G, Gatti F, Gattolin A, Gelati S, Gelmini R, Ghazouani O, Gioffrè A, Gobbi S, Grammatico V, Guariniello A, Giannessi S, Guerrieri M, Guerriero L, Guerriero G, Impellizzeri H, Izzo M, Jovine E, Lezoche G, Lirusso C, Lombardi R, Longoni M, Lucchi A, Luzzi AP, Marini P, Marrosu AG, Martino A, Mazza R, Mazzoccato S, Medas F, Meloni A, Milone M, Minciotti E, Monari F, Moretto G, Muttillo IA, Navarra G, Neri S, Oldani A, Olmi S, Opocher E, Osenda E, Ottonello R, Panebianco V, Pavanello M, Pecchini F, Pellegrino L, Pennisi D, Perrotta N, Pertile D, Petri R, Picchetto A, Piccoli M, Pirrera B, Pisani Ceretti A, Pisano M, Podda M, Portolani N, Presenti L, Puzziello A, Razzi S, Rega D, Restini E, Ricci G, Rigamonti M, Rivolta U, Robustelli V, Romairone E, Rosati R, Rosso E, Roviello F, Sala S, Santarelli M, Sarro G, Sartori A, Scabini S, Scognamillo F, Sechi R, Solaini L, Soliani G, Soliani P, Soligo E, Sorrentino M, Spinoglio G, Stratta E, Taddei A, Talamo G, Targa S, Tartaglia N, Testa S, Ubiali P, Valeri A, Vasta F, Verzelli A, Vicentini R, Viola G, Violi V, Zago M, Zampino L.

Subjects
Male, medicine.medical_specialty, Anastomosis, Colon, Intracorporeal anastomosis, Outcomes, Laparoscopic colectomy, Article, Intracorporeal anastomosi, Ileo-colic anastomosis, Laparoscopy, Postoperative complications, Right hemicolectomy, Aged, Anastomosis, Surgical, Colectomy, Colonic Neoplasms, Female, Humans, Prospective Studies, Treatment Outcome, Economica, Surgical, medicine, LS7_1, LS7_4, Right hemicolectomy, Ileo-colic anastomosis, Laparoscopy, Postoperative complications, Intracorporeal anastomosis, Outcomes, Outcome, LS7_9, medicine.diagnostic_test, business.industry, General surgery, Right hemicolectomy · Ileo-colic anastomosis · Laparoscopy · Postoperative complications · Intracorporeal anastomosis · Outcomes, Correction, Postoperative complication, Ileo-colic anastomosi, Prospective trial, Surgery, Side to side anastomosis, business, Laparoscopic right hemicolectomy
Abstract

Background While laparoscopic approach for right hemicolectomy (LRH) is considered appropriate for the surgical treatment of both malignant and benign diseases of right colon, there is still debate about how to perform the ileo-colic anastomosis. The ColonDxItalianGroup (CoDIG) was designed as a cohort, observational, prospective, multi-center national study with the aims of evaluating the surgeons’ attitude regarding the intracorporeal (ICA) or extra-corporeal (ECA) anastomotic technique and the related surgical outcomes. Methods One hundred and twenty-five Surgical Units experienced in colorectal and advanced laparoscopic surgery were invited and 85 of them joined the study. Each center was asked not to change its surgical habits. Data about demographic characteristics, surgical technique and postoperative outcomes were collected through the official SICE website database. One thousand two hundred and twenty-five patients were enrolled between March 2018 and September 2018. Results ICA was performed in 70.4% of cases, ECA in 29.6%. Isoperistaltic anastomosis was completed in 85.6%, stapled in 87.9%. Hand-sewn enterotomy closure was adopted in 86%. Postoperative complications were reported in 35.4% for ICA and 50.7% for ECA; no significant difference was found according to patients’ characteristics and technologies used. Median hospital stay was significantly shorter for ICA (7.3 vs. 9 POD). Postoperative pain in patients not prescribed opioids was significantly lower in ICA group. Conclusions In our survey, a side-to-side isoperistaltic stapled ICA with hand-sewn enterotomy closure is the most frequently adopted technique to perform ileo-colic anastomosis after any indications for elective LRH. According to literature, our study confirmed better short-term outcomes for ICA, with reduction of hospital stay and postoperative pain. Trial registration Clinical trial (Identifier: NCT03934151).

Published
2020

13. Co-circulation of SARS-CoV-2 Alpha and Gamma variants in Italy, February and March 2021

Author

Stefanelli, P., Trentini, F., Guzzetta, G., Marziano, V., Mammone, A., Schepisi, M. S., Poletti, P., Grane, C. M., Manica, M., del Manso, M., Andrianou, X., Ajelli, M., Rezza, G., Brusaferro, S., Merler, S., Di Martino, A., Ambrosio, L., Lo Presti, A., Fiore, S., Fabiani, C., Benedetti, E., Di Mario, G., Facchini, M., Puzelli, S., Calzoletti, L., Fontana, S., Venturi, G., Fortuna, C., Marsili, G., Amendola, A., Stuppia, L., Savini, G., Picerno, A., Lopizzo, T., Dell'Edera, D., Minchella, P., Greco, F., Viglietto, G., Atripaldi, L., Limone, A., D'Agaro, P., Licastro, D., Pongolini, S., Sambri, V., Dirani, G., Zannoli, S., Affanni, P., Colucci, M. E., Capobianchi, M. R., Icardi, G., Bruzzone, B., Lillo, F., Orsi, A., Pariani, E., Baldanti, F., Molecolare, U. V., Gismondo, M. R., Maggi, F., Caruso, A., Ceriotti, F., Boniotti, M. B., Barbieri, I., Bagnarelli, P., Menzo, S., Garofalo, S., Scutella, M., Pagani, E., Collini, L., Ghisetti, V., Brossa, S., Ru, G., Bozzetta, E., Chironna, M., Parisi, A., Rubino, S., Serra, C., Piras, G., Coghe, F., Vitale, F., Tramuto, F., Scalia, G., Palermo, C. I., Mancuso, G., Pollicino, T., Di Gaudio, F., Vullo, S., Reale, S., Cusi, M. G., Rossolini, G. M., Pistello, M., Mencacci, A., Camilloni, B., Severini, S., Di Benedetto, M., Terregino, C., Monne, I., Biscaro, V., Stefanelli P, Trentini F, Guzzetta G, Marziano V, Mammone A, Sane Schepisi M, Poletti P, Molina Grané C, Manica M, Del Manso M, Andrianou X, Ajelli M, Rezza G, Brusaferro S, Merler S, Vitale F, Tramuto F, Stefanelli P., Trentini F., Guzzetta G., Marziano V., Mammone A., Sane Schepisi M., Poletti P., Molina Grane C., Manica M., Del Manso M., Andrianou X., Ajelli M., Rezza G., Brusaferro S., Merler S., Sambri V, and (membro del COVID-19 National Microbiology Surveillance Study Group)

Subjects
Epidemiology, SARS-CoV-2, Public Health, Environmental and Occupational Health, COVID-19, co-circulation, lineage, SARS-CoV-2 variant of concern, transmissibility, Humans, Italy, Models, Theoretical, Settore MED/42 - Igiene Generale E Applicata, SARS-COV-2 VARIANT OF CONCERN, CO-CIRCULATION, LINEAGE, TRANSMISSIBILITY, HUMANS, ITALY, MODELS, THEORETICAL, COVID-19, SARS-COV-2, Theoretical, Models, Virology, Human
Abstract

Background Several SARS-CoV-2 variants of concern (VOC) have emerged through 2020 and 2021. There is need for tools to estimate the relative transmissibility of emerging variants of SARS-CoV-2 with respect to circulating strains. Aim We aimed to assess the prevalence of co-circulating VOC in Italy and estimate their relative transmissibility. Methods We conducted two genomic surveillance surveys on 18 February and 18 March 2021 across the whole Italian territory covering 3,243 clinical samples and developed a mathematical model that describes the dynamics of co-circulating strains. Results The Alpha variant was already dominant on 18 February in a majority of regions/autonomous provinces (national prevalence: 54%) and almost completely replaced historical lineages by 18 March (dominant across Italy, national prevalence: 86%). We found a substantial proportion of the Gamma variant on 18 February, almost exclusively in central Italy (prevalence: 19%), which remained similar on 18 March. Nationally, the mean relative transmissibility of Alpha ranged at 1.55–1.57 times the level of historical lineages (95% CrI: 1.45–1.66). The relative transmissibility of Gamma varied according to the assumed degree of cross-protection from infection with other lineages and ranged from 1.12 (95% CrI: 1.03–1.23) with complete immune evasion to 1.39 (95% CrI: 1.26–1.56) for complete cross-protection. Conclusion We assessed the relative advantage of competing viral strains, using a mathematical model assuming different degrees of cross-protection. We found substantial co-circulation of Alpha and Gamma in Italy. Gamma was not able to outcompete Alpha, probably because of its lower transmissibility.

Published
2022

14. Characteristics of SARS-CoV-2 variants of concern B.1.1.7, B.1.351 or P.1: data from seven EU/EEA countries, weeks 38/2020 to 10/2021

Author

Funk T., Pharris A., Spiteri G., Bundle N., Melidou A., Carr M., Gonzalez G., Garcia-Leon A., Crispie F., O'Connor L., Murphy N., Mossong J., Vergison A., Wienecke-Baldacchino A. K., Abdelrahman T., Riccardo F., Stefanelli P., Di Martino A., Bella A., Lo Presti A., Casaca P., Moreno J., Borges V., Isidro J., Ferreira R., Gomes J. P., Dotsenko L., Suija H., Epstein J., Sadikova O., Sepp H., Ikonen N., Savolainen-Kopra C., Blomqvist S., Mottonen T., Helve O., Gomes-Dias J., Adlhoch C., Macori G., Russell L., Yandle Z., Bennett C., O'Byrne E., Murphy A., Tuite G., Conroy A., Duffy M., Morley U., Keoghan B., Ford I., Kennedy M., McDonnell S., Flynn A., Clarke A., Crowley A., Martin C., Kelly E., Foxton J., Hare D., Dunford L., Connell J., Moran J., Dean J., Fanning S., Rajan L., De Gascun C., Kenny J., Cotter P., Walsh C., Lawton E., Fitzpatrick A., Mullins E., Della Bartola M., McCabe M., Stapleton P., Meaney C., Fanning L., Prentice M., MacSharry J., Dempsey C., Mallon P., Leon A., Chaturvedi A., Coughlan S., McAndrew G., Reddington K., Walsh F., Fitzpatrick D., Smyth C., O'Dwyer T., Chambers T., Clarke L., Jebb D., Klopp J., Kavanagh D., Haslam K., Buckley P., Lemass K., Fitzpatrick F., Burns K., Cafferkey J., Richmond A., Foley M., Sanchez-Morgado J., Chalapati S., Pinnamaneni N., Crosbie C., Limbachiya D., Tinago W., Garcia Leon A. A., Miles S., Alalwan D., Negi R., Macken A., Feeney E., Kenny G., McCann K., Kelly N., Blair M., McCann R., Kenny C., O'Brion C., Waqas S., Savinelli S., Doran P., Bracken T., Varghese P., Lambert J. S., Cotter A., Muldoon E., Sheehan G., McGinty T., Lambert J., Green S., Leamy K., de Barra E., McConkey S., Kelly C., Horgan M., Sadlier C., Yousif O., O'Donnell J., Fitzgerald M., Petty-Saphon N., Cuddihy J., Fiore S., Fabiani C., Benedetti E., Di Mario G., Facchini M., Puzelli S., Calzoletti L., Fontana S., Venturi G., Fortuna C., Marsili G., Amendola A., Stuppia L., Savini G., Picerno A., Lopizzo T., Dell'Edera D., Minchella P., Greco F., Mauro M. V., Viglietto G., Atripaldi L., Limone A., D'Agaro P., Licastro D., Marcello A., Capobianchi M. R., Icardi G., Bruzzone B., Lillo F., Orsi A., Pariani E., Baldanti F., Gismondo M. R., Maggi F., Caruso A., Ceriotti F., Boniotti B., Bagnarelli P., Garofalo S., Scutella M., Pagani E., Collini L., Ghisetti V., Ru G., Chironna M., Parisi A., Rubino S., Serra C., Piras G., Coghe F., Vitale F., Tramuto F., Scalia G., Palermo C. I., Mancuso G., Di Gaudio F., Vullo S., Reale S., Cusi M. G., Rossolini G. M., Pistello M., Mencacci A., Camilloni B., Severini S., Di Benedetto M., Calogero T., Monne I., Biscaro V., COVID Study Groups, Funk T., Pharris A., Spiteri G., Bundle N., Melidou A., Carr M., Gonzalez G., Garcia-Leon A., Crispie F., O'Connor L., Murphy N., Mossong J., Vergison A., Wienecke-Baldacchino A.K., Abdelrahman T., Riccardo F., Stefanelli P., Di Martino A., Bella A., Lo Presti A., Casaca P., Moreno J., Borges V., Isidro J., Ferreira R., Gomes J.P., Dotsenko L., Suija H., Epstein J., Sadikova O., Sepp H., Ikonen N., Savolainen-Kopra C., Blomqvist S., Mottonen T., Helve O., Gomes-Dias J., Adlhoch C., Macori G., Russell L., Yandle Z., Bennett C., O'Byrne E., Murphy A., Tuite G., Conroy A., Duffy M., Morley U., Keoghan B., Ford I., Kennedy M., McDonnell S., Flynn A., Clarke A., Crowley A., Martin C., Kelly E., Foxton J., Hare D., Dunford L., Connell J., Moran J., Dean J., Fanning S., Rajan L., De Gascun C., Kenny J., Cotter P., Walsh C., Lawton E., Fitzpatrick A., Mullins E., Della Bartola M., McCabe M., Stapleton P., Meaney C., Fanning L., Prentice M., MacSharry J., Dempsey C., Mallon P., Leon A., Chaturvedi A., Coughlan S., McAndrew G., Reddington K., Walsh F., Fitzpatrick D., Smyth C., O'Dwyer T., Chambers T., Clarke L., Jebb D., Klopp J., Kavanagh D., Haslam K., Buckley P., Lemass K., Fitzpatrick F., Burns K., Cafferkey J., Richmond A., Foley M., Sanchez-Morgado J., Chalapati S., Pinnamaneni N., Crosbie C., Limbachiya D., Tinago W., Garcia Leon A.A., Miles S., Alalwan D., Negi R., Macken A., Feeney E., Kenny G., McCann K., Kelly N., Blair M., McCann R., Kenny C., O'Brion C., Waqas S., Savinelli S., Doran P., Bracken T., Varghese P., Lambert J.S., Cotter A., Muldoon E., Sheehan G., McGinty T., Lambert J., Green S., Leamy K., de Barra E., McConkey S., Kelly C., Horgan M., Sadlier C., Yousif O., O'Donnell J., Fitzgerald M., Petty-Saphon N., Cuddihy J., Fiore S., Fabiani C., Benedetti E., Di Mario G., Facchini M., Puzelli S., Calzoletti L., Fontana S., Venturi G., Fortuna C., Marsili G., Amendola A., Stuppia L., Savini G., Picerno A., Lopizzo T., Dell'Edera D., Minchella P., Greco F., Mauro M.V., Viglietto G., Atripaldi L., Limone A., D'Agaro P., Licastro D., Marcello A., Capobianchi M.R., Icardi G., Bruzzone B., Lillo F., Orsi A., Pariani E., Baldanti F., Gismondo M.R., Maggi F., Caruso A., Ceriotti F., Boniotti B., Bagnarelli P., Garofalo S., Scutella M., Pagani E., Collini L., Ghisetti V., Ru G., Chironna M., Parisi A., Rubino S., Serra C., Piras G., Coghe F., Vitale F., Tramuto F., Scalia G., Palermo C.I., Mancuso G., Di Gaudio F., Vullo S., Reale S., Cusi M.G., Rossolini G.M., Pistello M., Mencacci A., Camilloni B., Severini S., Di Benedetto M., Calogero T., Monne I., Biscaro V., and COVID Study Groups

Subjects
Infecções Respiratórias, 2019-20 coronavirus outbreak, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Critical Care, Epidemiology, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), variants of concern, Settore MED/42 - Igiene Generale E Applicata, 03 medical and health sciences, 0302 clinical medicine, Virology, Internal medicine, Medicine, Humans, Intensive care admission, 030212 general & internal medicine, COVID-19, Europe, SARS-CoV-2, surveillance, Surveillance, business.industry, 030503 health policy & services, Public Health, Environmental and Occupational Health, Odds ratio, Confidence interval, Variants of Concern, COVID-19, Europe, SARS-CoV-2, surveillance, variants of concern, 0305 other medical science, business, Rapid Communication, Human
Abstract

COVID study groups - PORTUGAL: Portuguese Laboratory Network for the Diagnosis of COVID-19 and Public Health Department of the Health Administrative Regions, Physicians that provided data and samples from suspected cases and SARS-CoV-2 genetic characterization. INSA laboratory team for the diagnosis of SARS-CoV-2. Algarve Biomedical Center and Unilabs. We compared 19,207 cases of SARS-CoV-2 variant B.1.1.7/S gene target failure (SGTF), 436 B.1.351 and 352 P.1 to non-variant cases reported by seven European countries. COVID-19 cases with these variants had significantly higher adjusted odds ratios for hospitalisation (B.1.1.7/SGTF: 1.7, 95% confidence interval (CI): 1.0-2.9; B.1.351: 3.6, 95% CI: 2.1-6.2; P.1: 2.6, 95% CI: 1.4-4.8) and B.1.1.7/SGTF and P.1 cases also for intensive care admission (B.1.1.7/SGTF: 2.3, 95% CI: 1.4-3.5; P.1: 2.2, 95% CI: 1.7-2.8). ECDC internal funds. The ICSC and the AIID Cohort are supported by Science Foundation Ireland under the Science Foundation Ireland, Enterprise Ireland, IDA Ireland COVID-19 Rapid Response Funding Call (Grant number: COVID-RRC 20/COV/0103 and COVID-RRC 20/COV/0305). info:eu-repo/semantics/publishedVersion

Published
2021

15. Determinants of SARS-CoV-2 infection in Italian healthcare workers: a multicenter study

Author

Boffetta P., Violante F., Durando P., De Palma G., Pira E., Vimercati L., Cristaudo A., Icardi G., Sala E., Coggiola M., Tafuri S., Gattini V., Apostoli P., Spatari G., De Maria L., Caputi A., Sponselli S., Mastrippolito C., Zunarelli C., Di Felice G., Visci G., Albini E., Sansone E., Tomasi C., Bisioli A., Cipriani L., De Bellis A., Tiraboschi M. M., Paraggio E., Rubino S., Capuzzi M., Dini G., Bruzzone B., Debarbieri N., Montecucco A., Orsi A., Rahmani A., Ricucci V., Guglielmi G., Fiorentino L., Brilli C., Godono A., Declementi M., Mansour I., Milanesio N., Garzaro G., Scarmozzino A., Gullino A., Boffetta P., Violante F., Durando P., De Palma G., Pira E., Vimercati L., Cristaudo A., Icardi G., Sala E., Coggiola M., Tafuri S., Gattini V., Apostoli P., Spatari G., De Maria L., Caputi A., Sponselli S., Mastrippolito C., Zunarelli C., Di Felice G., Visci G., Albini E., Sansone E., Tomasi C., Bisioli A., Cipriani L., De Bellis A., Tiraboschi M.M., Paraggio E., Rubino S., Capuzzi M., Dini G., Bruzzone B., Debarbieri N., Montecucco A., Orsi A., Rahmani A., Ricucci V., Guglielmi G., Fiorentino L., Brilli C., Godono A., Declementi M., Mansour I., Milanesio N., Garzaro G., Scarmozzino A., and Gullino A.

Subjects
Adult, Male, medicine.medical_specialty, Science, Health Personnel, 030501 epidemiology, Logistic regression, Lower risk, Article, Malaise, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, COVID-19, Female, Humans, Italy, Mass Screening, Middle Aged, Occupational Diseases, SARS-CoV-2, Epidemiology, Medicine, 030212 general & internal medicine, Risk factor, Personal protective equipment, Mass screening, Multidisciplinary, business.industry, Risk of infection, Odds ratio, Confidence interval, Occupational Disease, Risk factors, Emergency medicine, medicine.symptom, 0305 other medical science, business, Health occupations, Human
Abstract

BackgroundHealthcare workers (HCW) are at increased risk of being infected with SARS-CoV-2, yet limited information is available on risk factors of infection.MethodsWe pooled data on occupational surveillance of 10,654 HCW who were tested for SARS-CoV-2 infection in six Italian centers. Information was available on demographics, job title, department of employment, source of exposure, use of personal protective equipment (PPE), and COVID-19-related symptoms. We fitted multivariable logistic regression models to calculate odds ratios (OR) and 95% confidence intervals (CI).FindingsThe prevalence of infection varied across centers and ranged from 3.0% to 22.0%, being strongly correlated with that of the respective areas. Women were at lower risk of infection compared to men. Fever, cough, dyspnea and malaise were the symptoms most strongly associated with infection, together with anosmia and ageusia. No differences in the risk of infection were detected between job titles, or working in a COVID-19 designated department. Reported contact with a patient inside or outside the workplace was a risk factor. Use of a mask was strongly protective against risk of infection as was use of gloves. The use of a mask by the source of exposure (patient or colleague) had an independent effect in reducing infection risk.

Published
2021

18. Past, present, and future of global health financing: A review of development assistance, government, out-of-pocket, and other private spending on health for 195 countries, 1995-2050

Author

Chang, A, Cowling, K, Micah, A, Chapin, A, Chen, C, Ikilezi, G, Sadat, N, Tsakalos, G, Wu, J, Younker, T, Zhao, Y, Zlavog, B, Abbafati, C, Ahmed, A, Alam, K, Alipour, V, Aljunid, S, Almalki, M, Alvis-Guzman, N, Ammar, W, Andrei, C, Anjomshoa, M, Antonio, C, Arabloo, J, Aremu, O, Ausloos, M, Avila-Burgos, L, Awasthi, A, Ayanore, M, Azari, S, Azzopardi-Muscat, N, Bagherzadeh, M, Barnighausen, T, Baune, B, Bayati, M, Belay, Y, Belete, H, Berbada, D, Berman, A, Beuran, M, Bijani, A, Busse, R, Cahuana-Hurtado, L, Camera, L, Catala-Lopez, F, Chauhan, B, Constantin, M, Crowe, C, Cucu, A, Dalal, K, De Neve, J, Deiparine, S, Demeke, F, Do, H, Dubey, M, Tantawi, M, Eskandarieh, S, Esmaeili, R, Fakhar, M, Fazaeli, A, Fischer, F, Foigt, N, Fukumoto, T, Fullman, N, Galan, A, Gamkrelidze, A, Gezae, K, Ghajar, A, Ghashghaee, A, Goginashvili, K, Haakenstad, A, Bidgoli, H, Hamidi, S, Harb, H, Hasanpoor, E, Hassen, H, Hay, S, Hendrie, D, Henok, A, Heredia-Pi, I, Herteliu, C, Hoang, C, Hole, M, Rad, E, Hossain, N, Hosseinzadeh, M, Hostiuc, S, Ilesanmi, O, Irvani, S, Jakovljevic, M, Jalali, A, James, S, Jonas, J, Jurisson, M, Kadel, R, Matin, B, Kasaeian, A, Kasaye, H, Kassaw, M, Karyani, A, Khabiri, R, Khan, J, Khan, M, Khang, Y, Kisa, A, Kissimova-Skarbek, K, Kohler, S, Koyanagi, A, Krohn, K, Leung, R, Lim, L, Lorkowski, S, Majeed, A, Malekzadeh, R, Mansourian, M, Mantovani, L, Massenburg, B, Mckee, M, Mehta, V, Meretoja, A, Meretoja, T, Kostova, N, Miller, T, Mirrakhimov, E, Mohajer, B, Darwesh, A, Mohammed, S, Mohebi, F, Mokdad, A, Morrison, S, Mousavi, S, Muthupandian, S, Nagarajan, A, Nangia, V, Negoi, I, Nguyen, C, Nguyen, H, Nguyen, S, Nosratnejad, S, Oladimeji, O, Olgiati, S, Olusanya, J, Onwujekwe, O, Otstavnov, S, Pana, A, Pereira, D, Piroozi, B, Prada, S, Qorbani, M, Rabiee, M, Rabiee, N, Rafiei, A, Rahim, F, Rahimi-Movaghar, V, Ram, U, Ranabhat, C, Ranta, A, Rawaf, D, Rawaf, S, Rezaei, S, Roro, E, Rostami, A, Rubino, S, Salahshoor, M, Samy, A, Sanabria, J, Santos, J, Milicevic, M, Jose, B, Savic, M, Schwendicke, F, Sepanlou, S, Sepehrimanesh, M, Sheikh, A, Shrime, M, Sisay, S, Soltani, S, Soofi, M, Srinivasan, V, Tabares-Seisdedos, R, Torre, A, Tovani-Palone, M, Tran, B, Tran, K, Undurraga, E, Valdez, P, Van Boven, J, Vargas, V, Veisani, Y, Violante, F, Vladimirov, S, Vlassov, V, Vollmer, S, Vu, G, Wolfe, C, Yonemoto, N, Younis, M, Yousefifard, M, Zaman, S, Zangeneh, A, Zegeye, E, Ziapour, A, Chew, A, Murray, C, Dieleman, J, Chang A. Y., Cowling K., Micah A. E., Chapin A., Chen C. S., Ikilezi G., Sadat N., Tsakalos G., Wu J., Younker T., Zhao Y., Zlavog B. S., Abbafati C., Ahmed A. E., Alam K., Alipour V., Aljunid S. M., Almalki M. J., Alvis-Guzman N., Ammar W., Andrei C. L., Anjomshoa M., Antonio C. A. T., Arabloo J., Aremu O., Ausloos M., Avila-Burgos L., Awasthi A., Ayanore M. A., Azari S., Azzopardi-Muscat N., Bagherzadeh M., Barnighausen T. W., Baune B. T., Bayati M., Belay Y. B., Belay Y. A., Belete H., Berbada D. A., Berman A. E., Beuran M., Bijani A., Busse R., Cahuana-Hurtado L., Camera L. A., Catala-Lopez F., Chauhan B. G., Constantin M. -M., Crowe C. S., Cucu A., Dalal K., De Neve J. -W., Deiparine S., Demeke F. M., Do H. P., Dubey M., Tantawi M. E., Eskandarieh S., Esmaeili R., Fakhar M., Fazaeli A. A., Fischer F., Foigt N. A., Fukumoto T., Fullman N., Galan A., Gamkrelidze A., Gezae K. E., Ghajar A., Ghashghaee A., Goginashvili K., Haakenstad A., Bidgoli H. H., Hamidi S., Harb H. L., Hasanpoor E., Hassen H. Y., Hay S. I., Hendrie D., Henok A., Heredia-Pi I., Herteliu C., Hoang C. L., Hole M. K., Rad E. H., Hossain N., Hosseinzadeh M., Hostiuc S., Ilesanmi O. S., Irvani S. S. N., Jakovljevic M., Jalali A., James S. L., Jonas J. B., Jurisson M., Kadel R., Matin B. K., Kasaeian A., Kasaye H. K., Kassaw M. W., Karyani A. K., Khabiri R., Khan J., Khan M. N., Khang Y. -H., Kisa A., Kissimova-Skarbek K., Kohler S., Koyanagi A., Krohn K. J., Leung R., Lim L. -L., Lorkowski S., Majeed A., Malekzadeh R., Mansourian M., Mantovani L. G., Massenburg B. B., Mckee M., Mehta V., Meretoja A., Meretoja T. J., Kostova N. M., Miller T. R., Mirrakhimov E. M., Mohajer B., Darwesh A. M., Mohammed S., Mohebi F., Mokdad A. H., Morrison S. D., Mousavi S. M., Muthupandian S., Nagarajan A. J., Nangia V., Negoi I., Nguyen C. T., Nguyen H. L. T., Nguyen S. H., Nosratnejad S., Oladimeji O., Olgiati S., Olusanya J. O., Onwujekwe O. E., Otstavnov S. S., Pana A., Pereira D. M., Piroozi B., Prada S. I., Qorbani M., Rabiee M., Rabiee N., Rafiei A., Rahim F., Rahimi-Movaghar V., Ram U., Ranabhat C. L., Ranta A., Rawaf D. L., Rawaf S., Rezaei S., Roro E. M., Rostami A., Rubino S., Salahshoor M., Samy A. M., Sanabria J., Santos J. V., Milicevic M. M. S., Jose B. P. S., Savic M., Schwendicke F., Sepanlou S. G., Sepehrimanesh M., Sheikh A., Shrime M. G., Sisay S., Soltani S., Soofi M., Srinivasan V., Tabares-Seisdedos R., Torre A., Tovani-Palone M. R., Tran B. X., Tran K. B., Undurraga E. A., Valdez P. R., Van Boven J. F. M., Vargas V., Veisani Y., Violante F. S., Vladimirov S. K., Vlassov V., Vollmer S., Vu G. T., Wolfe C. D. A., Yonemoto N., Younis M. Z., Yousefifard M., Zaman S. B., Zangeneh A., Zegeye E. A., Ziapour A., Chew A., Murray C. J. L., Dieleman J. L., Chang, A, Cowling, K, Micah, A, Chapin, A, Chen, C, Ikilezi, G, Sadat, N, Tsakalos, G, Wu, J, Younker, T, Zhao, Y, Zlavog, B, Abbafati, C, Ahmed, A, Alam, K, Alipour, V, Aljunid, S, Almalki, M, Alvis-Guzman, N, Ammar, W, Andrei, C, Anjomshoa, M, Antonio, C, Arabloo, J, Aremu, O, Ausloos, M, Avila-Burgos, L, Awasthi, A, Ayanore, M, Azari, S, Azzopardi-Muscat, N, Bagherzadeh, M, Barnighausen, T, Baune, B, Bayati, M, Belay, Y, Belete, H, Berbada, D, Berman, A, Beuran, M, Bijani, A, Busse, R, Cahuana-Hurtado, L, Camera, L, Catala-Lopez, F, Chauhan, B, Constantin, M, Crowe, C, Cucu, A, Dalal, K, De Neve, J, Deiparine, S, Demeke, F, Do, H, Dubey, M, Tantawi, M, Eskandarieh, S, Esmaeili, R, Fakhar, M, Fazaeli, A, Fischer, F, Foigt, N, Fukumoto, T, Fullman, N, Galan, A, Gamkrelidze, A, Gezae, K, Ghajar, A, Ghashghaee, A, Goginashvili, K, Haakenstad, A, Bidgoli, H, Hamidi, S, Harb, H, Hasanpoor, E, Hassen, H, Hay, S, Hendrie, D, Henok, A, Heredia-Pi, I, Herteliu, C, Hoang, C, Hole, M, Rad, E, Hossain, N, Hosseinzadeh, M, Hostiuc, S, Ilesanmi, O, Irvani, S, Jakovljevic, M, Jalali, A, James, S, Jonas, J, Jurisson, M, Kadel, R, Matin, B, Kasaeian, A, Kasaye, H, Kassaw, M, Karyani, A, Khabiri, R, Khan, J, Khan, M, Khang, Y, Kisa, A, Kissimova-Skarbek, K, Kohler, S, Koyanagi, A, Krohn, K, Leung, R, Lim, L, Lorkowski, S, Majeed, A, Malekzadeh, R, Mansourian, M, Mantovani, L, Massenburg, B, Mckee, M, Mehta, V, Meretoja, A, Meretoja, T, Kostova, N, Miller, T, Mirrakhimov, E, Mohajer, B, Darwesh, A, Mohammed, S, Mohebi, F, Mokdad, A, Morrison, S, Mousavi, S, Muthupandian, S, Nagarajan, A, Nangia, V, Negoi, I, Nguyen, C, Nguyen, H, Nguyen, S, Nosratnejad, S, Oladimeji, O, Olgiati, S, Olusanya, J, Onwujekwe, O, Otstavnov, S, Pana, A, Pereira, D, Piroozi, B, Prada, S, Qorbani, M, Rabiee, M, Rabiee, N, Rafiei, A, Rahim, F, Rahimi-Movaghar, V, Ram, U, Ranabhat, C, Ranta, A, Rawaf, D, Rawaf, S, Rezaei, S, Roro, E, Rostami, A, Rubino, S, Salahshoor, M, Samy, A, Sanabria, J, Santos, J, Milicevic, M, Jose, B, Savic, M, Schwendicke, F, Sepanlou, S, Sepehrimanesh, M, Sheikh, A, Shrime, M, Sisay, S, Soltani, S, Soofi, M, Srinivasan, V, Tabares-Seisdedos, R, Torre, A, Tovani-Palone, M, Tran, B, Tran, K, Undurraga, E, Valdez, P, Van Boven, J, Vargas, V, Veisani, Y, Violante, F, Vladimirov, S, Vlassov, V, Vollmer, S, Vu, G, Wolfe, C, Yonemoto, N, Younis, M, Yousefifard, M, Zaman, S, Zangeneh, A, Zegeye, E, Ziapour, A, Chew, A, Murray, C, Dieleman, J, Chang A. Y., Cowling K., Micah A. E., Chapin A., Chen C. S., Ikilezi G., Sadat N., Tsakalos G., Wu J., Younker T., Zhao Y., Zlavog B. S., Abbafati C., Ahmed A. E., Alam K., Alipour V., Aljunid S. M., Almalki M. J., Alvis-Guzman N., Ammar W., Andrei C. L., Anjomshoa M., Antonio C. A. T., Arabloo J., Aremu O., Ausloos M., Avila-Burgos L., Awasthi A., Ayanore M. A., Azari S., Azzopardi-Muscat N., Bagherzadeh M., Barnighausen T. W., Baune B. T., Bayati M., Belay Y. B., Belay Y. A., Belete H., Berbada D. A., Berman A. E., Beuran M., Bijani A., Busse R., Cahuana-Hurtado L., Camera L. A., Catala-Lopez F., Chauhan B. G., Constantin M. -M., Crowe C. S., Cucu A., Dalal K., De Neve J. -W., Deiparine S., Demeke F. M., Do H. P., Dubey M., Tantawi M. E., Eskandarieh S., Esmaeili R., Fakhar M., Fazaeli A. A., Fischer F., Foigt N. A., Fukumoto T., Fullman N., Galan A., Gamkrelidze A., Gezae K. E., Ghajar A., Ghashghaee A., Goginashvili K., Haakenstad A., Bidgoli H. H., Hamidi S., Harb H. L., Hasanpoor E., Hassen H. Y., Hay S. I., Hendrie D., Henok A., Heredia-Pi I., Herteliu C., Hoang C. L., Hole M. K., Rad E. H., Hossain N., Hosseinzadeh M., Hostiuc S., Ilesanmi O. S., Irvani S. S. N., Jakovljevic M., Jalali A., James S. L., Jonas J. B., Jurisson M., Kadel R., Matin B. K., Kasaeian A., Kasaye H. K., Kassaw M. W., Karyani A. K., Khabiri R., Khan J., Khan M. N., Khang Y. -H., Kisa A., Kissimova-Skarbek K., Kohler S., Koyanagi A., Krohn K. J., Leung R., Lim L. -L., Lorkowski S., Majeed A., Malekzadeh R., Mansourian M., Mantovani L. G., Massenburg B. B., Mckee M., Mehta V., Meretoja A., Meretoja T. J., Kostova N. M., Miller T. R., Mirrakhimov E. M., Mohajer B., Darwesh A. M., Mohammed S., Mohebi F., Mokdad A. H., Morrison S. D., Mousavi S. M., Muthupandian S., Nagarajan A. J., Nangia V., Negoi I., Nguyen C. T., Nguyen H. L. T., Nguyen S. H., Nosratnejad S., Oladimeji O., Olgiati S., Olusanya J. O., Onwujekwe O. E., Otstavnov S. S., Pana A., Pereira D. M., Piroozi B., Prada S. I., Qorbani M., Rabiee M., Rabiee N., Rafiei A., Rahim F., Rahimi-Movaghar V., Ram U., Ranabhat C. L., Ranta A., Rawaf D. L., Rawaf S., Rezaei S., Roro E. M., Rostami A., Rubino S., Salahshoor M., Samy A. M., Sanabria J., Santos J. V., Milicevic M. M. S., Jose B. P. S., Savic M., Schwendicke F., Sepanlou S. G., Sepehrimanesh M., Sheikh A., Shrime M. G., Sisay S., Soltani S., Soofi M., Srinivasan V., Tabares-Seisdedos R., Torre A., Tovani-Palone M. R., Tran B. X., Tran K. B., Undurraga E. A., Valdez P. R., Van Boven J. F. M., Vargas V., Veisani Y., Violante F. S., Vladimirov S. K., Vlassov V., Vollmer S., Vu G. T., Wolfe C. D. A., Yonemoto N., Younis M. Z., Yousefifard M., Zaman S. B., Zangeneh A., Zegeye E. A., Ziapour A., Chew A., Murray C. J. L., and Dieleman J. L.

Abstract

Background: Comprehensive and comparable estimates of health spending in each country are a key input for health policy and planning, and are necessary to support the achievement of national and international health goals. Previous studies have tracked past and projected future health spending until 2040 and shown that, with economic development, countries tend to spend more on health per capita, with a decreasing share of spending from development assistance and out-of-pocket sources. We aimed to characterise the past, present, and predicted future of global health spending, with an emphasis on equity in spending across countries. Methods: We estimated domestic health spending for 195 countries and territories from 1995 to 2016, split into three categories-government, out-of-pocket, and prepaid private health spending-and estimated development assistance for health (DAH) from 1990 to 2018. We estimated future scenarios of health spending using an ensemble of linear mixed-effects models with time series specifications to project domestic health spending from 2017 through 2050 and DAH from 2019 through 2050. Data were extracted from a broad set of sources tracking health spending and revenue, and were standardised and converted to inflation-adjusted 2018 US dollars. Incomplete or low-quality data were modelled and uncertainty was estimated, leading to a complete data series of total, government, prepaid private, and out-of-pocket health spending, and DAH. Estimates are reported in 2018 US dollars, 2018 purchasing-power parity-adjusted dollars, and as a percentage of gross domestic product. We used demographic decomposition methods to assess a set of factors associated with changes in government health spending between 1995 and 2016 and to examine evidence to support the theory of the health financing transition. We projected two alternative future scenarios based on higher government health spending to assess the potential ability of governments to generate more reso

Published
2019

19. Mapping routine measles vaccination in low- and middle-income countries

Author

Sbarra, AN, Rolfe, S, Nguyen, JQ, Earl, L, Galles, NC, Marks, A, Abbas, KM, Abbasi-Kangevari, M, Abbastabar, H, Abd-Allah, F, Abdelalim, A, Abdollahi, M, Abegaz, KH, Abiy, HAA, Abolhassani, H, Abreu, LG, Abrigo, MRM, Abushouk, AI, Accrombessi, MMK, Adabi, M, Adebayo, OM, Adekanmbi, V, Adetokunboh, OO, Adham, D, Afarideh, M, Aghaali, M, Ahmad, T, Ahmadi, R, Ahmadi, K, Ahmed, MB, Alanezi, FM, Alanzi, TM, Alcalde-Rabanal, JE, Alemnew, BT, Ali, BA, Ali, M, Alijanzadeh, M, Alinia, C, Alipoor, R, Alipour, V, Alizade, H, Aljunid, SM, Almasi, A, Almasi-Hashiani, A, Al-Mekhlafi, HM, Altirkawi, KA, Amare, B, Amini, S, Amini-Rarani, M, Amiri, F, Amit, AML, Amugsi, DA, Ancuceanu, R, Andrei, CL, Anjomshoa, M, Ansari, F, Ansari-Moghaddam, A, Ansha, MG, Antonio, CAT, Antriyandarti, E, Anvari, D, Arabloo, J, Arab-Zozani, M, Aremu, O, Armoon, B, Aryal, KK, Arzani, A, Asadi-Aliabadi, M, Asgari, S, Atafar, Z, Ausloos, M, Awoke, N, Quintanilla, BPA, Ayanore, MA, Aynalem, YA, Azadmehr, A, Azari, S, Babaee, E, Badawi, A, Badiye, AD, Bahrami, MA, Baig, AA, Bakhtiari, A, Balakrishnan, S, Banach, M, Banik, PC, Barac, A, Baradaran-Seyed, Z, Baraki, AG, Basu, S, Bayati, M, Bayou, YT, Bedi, N, Behzadifar, M, Bell, ML, Berbada, DA, Berhe, K, Bhattarai, S, Bhutta, ZA, Bijani, A, Birhanu, M, Bisanzio, D, Biswas, A, Bohlouli, S, Bolla, SR, Borzouei, S, Brady, OJ, Bragazzi, NL, Briko, AN, Briko, NI, Nagaraja, SB, Butt, ZA, Cámera, LA, Campos-Nonato, IR, Car, J, Cárdenas, R, Carvalho, F, Castaldelli-Maia, JM, Castro, F, Chattu, VK, Chehrazi, M, Chin, KL, Chu, D-T, Cook, AJ, Cormier, NM, Cunningham, B, Dahlawi, SMA, Damiani, G, Dandona, R, Dandona, L, Danovaro, MC, Dansereau, E, Daoud, F, Darwesh, AM, Darwish, AH, Das, JK, Weaver, ND, De Neve, J-W, Demeke, FM, Demis, AB, Denova-Gutiérrez, E, Desalew, A, Deshpande, A, Desta, DM, Dharmaratne, SD, Dhungana, GP, Dianatinasab, M, Diaz, D, Dipeolu, IO, Djalalinia, S, Do, HT, Dorostkar, F, Doshmangir, L, Doyle, KE, Dunachie, SJ, Duraes, AR, Kalan, ME, Leylabadlo, HE, Edinur, HA, Effiong, A, Eftekhari, A, El, Sayed, I, El, Sayed, Zaki, M, Elema, TB, Elhabashy, HR, El-Jaafary, SI, Elsharkawy, A, Emamian, MH, Enany, S, Eshrati, B, Eskandari, K, Eskandarieh, S, Esmaeilnejad, S, Esmaeilzadeh, F, Esteghamati, A, Etisso, AE, Farahmand, M, Faraon, EJA, Fareed, M, Faridnia, R, Farioli, A, Farzadfar, F, Fattahi, N, Fazlzadeh, M, Fereshtehnejad, S-M, Fernandes, E, Filip, I, Fischer, F, Foigt, NA, Folayan, MO, Foroutan, M, Fukumoto, T, Fullman, N, Gad, MM, Geberemariyam, BS, Gebrehiwot, TT, Gebrehiwot, AM, Gebremariam, KT, Gebremedhin, KB, Gebremeskel, GG, Gebreslassie, AA, Gedefaw, GA, Gezae, KE, Ghadiri, K, Ghaffari, R, Ghaffarifar, F, Ghajarzadeh, M, Gheshlagh, RG, Ghashghaee, A, Ghiasvand, H, Gholamian, A, Gilani, SA, Gill, PS, Girmay, A, Gomes, NGM, Gopalani, SV, Goulart, BNG, Grada, A, Guimarães, RA, Guo, Y, Gupta, R, Hafezi-Nejad, N, Haj-Mirzaian, A, Handiso, DW, Hanif, A, Haririan, H, Hasaballah, AI, Hasan, MM, Hasanpoor, E, Hasanzadeh, A, Hassanipour, S, Hassankhani, H, Heidari-Soureshjani, R, Henry, NJ, Herteliu, C, Heydarpour, F, Hollerich, GI, Rad, EH, Hoogar, P, Hossain, N, Hosseini, M, Hosseinzadeh, M, Househ, M, Hu, G, Huda, TM, Humayun, A, Ibitoye, SE, Ikilezi, G, Ilesanmi, OS, Ilic, IM, Ilic, MD, Imani-Nasab, MH, Inbaraj, LR, Iqbal, U, Irvani, SSN, Islam, SMS, Islam, MM, Iwu, CJ, Iwu, CCD, Jadidi-Niaragh, F, Jafarinia, M, Jahanmehr, N, Jakovljevic, M, Jalali, A, Jalilian, F, Javidnia, J, Jenabi, E, Jha, V, Ji, JS, John, O, Johnson, KB, Joukar, F, Jozwiak, JJ, Kabir, Z, Kabir, A, Kalani, H, Kalankesh, LR, Kalhor, R, Kamal, Z, Kanchan, T, Kapoor, N, Karami, M, Matin, BK, Karch, A, Karimi, SE, Kayode, GA, Karyani, AK, Keiyoro, PN, Khader, YS, Khafaie, MA, Khammarnia, M, Khan, MS, Khan, EA, Khan, J, Khan, MN, Khatab, K, Khater, MM, Khatib, MN, Khayamzadeh, M, Khazaei, M, Khazaei, S, Khosravi, A, Khubchandani, J, Kianipour, N, Kim, YJ, Kimokoti, RW, Kinyoki, DK, Kisa, A, Kisa, S, Kolola, T, Komaki, H, Kosen, S, Koul, PA, Koyanagi, A, Kraemer, MUG, Krishan, K, Kuate Defo, B, Kumar, M, Kumar, P, Kumar, GA, Kusuma, D, La Vecchia, C, Lacey, B, Lad, SD, Lal, DK, Lam, F, Lami, FH, Lansingh, VC, Larson, HJ, Lasrado, S, Lee, SWH, Lee, PH, LeGrand, KE, Lenjebo, TL, Li, S, Liang, X, Liu, PY, Lopukhov, PD, Machado, DB, Mahasha, PW, Mahdavi, MM, Maheri, M, Mahotra, NB, Maled, V, Maleki, S, Malik, MA, Malta, DC, Mansour-Ghanaei, F, Mansouri, B, Mansourian, M, Mansournia, MA, Martins-Melo, FR, Masaka, A, Mayala, BK, Mehndiratta, MM, Mehri, F, Mehta, KM, Memiah, PTN, Mendoza, W, Menezes, RG, Mengesha, MB, Mengesha, EW, Mestrovic, T, Mihretie, KM, Miller-Petrie, MK, Mills, EJ, Milne, GJ, Mirabi, P, Mirrakhimov, EM, Mirzaei, R, Mirzaei, M, Mirzaei, HR, Mirzaei, H, Mirzaei-Alavijeh, M, Moazen, B, Moghadaszadeh, M, Mohamadi, E, Mohammad, DK, Mohammad, Y, Mohammad, KA, Mohammad Gholi Mezerji, N, Mohammadbeigi, A, Mohammadian-Hafshejani, A, Mohammadpourhodki, R, Mohammed, S, Mohammed, AS, Mohammed, H, Mohebi, F, Mokdad, AH, Monasta, L, Moosavi, MA, Moosazadeh, M, Moradi, G, Moradi, M, Moradi-Joo, M, Moradi-Lakeh, M, Moradzadeh, R, Moraga, P, Mosapour, A, Mouodi, S, Mousavi, SM, Khaneghah, AM, Mueller, UO, Muluneh, AG, Munro, SB, Murray, CJL, Murthy, GVS, Muthupandian, S, Naderi, M, Nagarajan, AJ, Naghavi, M, Nangia, V, Nansseu, JR, Nayak, VC, Nazari, J, Ndwandwe, DE, Negoi, I, Ngunjiri, JW, Nguyen, HLT, Nguyen, CTK, Nguyen, TH, Nigatu, YT, Nikbakhsh, R, Nikfar, S, Nikpoor, AR, Ningrum, DNA, Nnaji, CA, Oh, I-H, Oladnabi, M, Olagunju, AT, Olusanya, JO, Olusanya, BO, Bali, AO, Omer, MO, Onwujekwe, OE, Osgood-Zimmerman, AE, Owolabi, MO, P, A, M, Padubidri, JR, Pakshir, K, Pana, A, Pandey, A, Pando-Robles, V, Pashaei, T, Pasupula, DK, Paternina-Caicedo, AJ, Patton, GC, Pazoki Toroudi, H, Pepito, VCF, Pescarini, JM, Pigott, DM, Pilgrim, T, Pirsaheb, M, Poljak, M, Postma, MJ, Pourjafar, H, Pourmalek, F, Pourmirza, Kalhori, R, Prada, SI, Prakash, S, Quazi Syed, Z, Quintana, H, Rabiee, N, Rabiee, M, Radfar, A, Rafiei, A, Rahim, F, Rajati, F, Rameto, MA, Ramezanzadeh, K, Ranabhat, CL, Rao, SJ, Rasella, D, Rastogi, P, Rathi, P, Rawaf, S, Rawaf, DL, Rawal, L, Rawassizadeh, R, Rawat, R, Renjith, V, Renzaho, AMN, Reshmi, B, Reta, MA, Rezaei, N, Rezai, MS, Rezapour, A, Riahi, SM, Ribeiro, AI, Rickard, J, Rios-Blancas, M, Rios-González, CM, Roever, L, Rostamian, M, Rubino, S, Rwegerera, GM, Saad, AM, Saadatagah, S, Sabour, S, Sadeghi, E, Moghaddam, SS, Saeidi, S, Sagar, R, Sahebkar, A, Sahraian, MA, Sajadi, SM, Salahshoor, MR, Salam, N, Salem, H, Salem, MR, Salomon, JA, Kafil, HS, Sambala, EZ, Samy, AM, Saraswathy, SYI, Sarmiento-Suárez, R, Saroshe, S, Sartorius, B, Sarveazad, A, Sathian, B, Sathish, T, Schaeffer, LE, Schwebel, DC, Senthilkumaran, S, Shabaninejad, H, Shahabi, S, Shaheen, AA, Shaikh, MA, Shalash, AS, Shams-Beyranvand, M, Shamsi, MB, Shamsizadeh, M, Sharafi, K, Sharifi, H, Sheikh, A, Sheikhtaheri, A, Shetty, RS, Shiferaw, WS, Shigematsu, M, Shin, JI, Shirkoohi, R, Siabani, S, Siddiqi, TJ, Silverberg, JIS, Simonetti, B, Singh, JA, Sinha, DN, Sinke, AH, Soheili, A, Sokhan, A, Soltani, S, Soofi, M, Sorrie, MB, Soyiri, IN, Spotin, A, Spurlock, EE, Sreeramareddy, CT, Sudaryanto, A, Sufiyan, MB, Suleria, HAR, Abdulkader, RS, Taherkhani, A, Tapak, L, Taveira, N, Taymoori, P, Tefera, YM, Tehrani-Banihashemi, A, Teklehaimanot, BF, Tekulu, GH, Tesfay, BE, Tessema, ZT, Tessema, B, Thankappan, KR, Tohidinik, HR, Topor-Madry, R, Tovani-Palone, MR, Tran, BX, Uddin, R, Ullah, I, Umeokonkwo, CD, Unnikrishnan, B, Upadhyay, E, Usman, MS, Vaezi, M, Valadan, Tahbaz, S, Valdez, PR, Vasseghian, Y, Veisani, Y, Violante, FS, Vollmer, S, Waheed, Y, Wakefield, J, Wang, Y, Wang, Y-P, Weldesamuel, GT, Werdecker, A, Westerman, R, Wiangkham, T, Wiens, KE, Wiysonge, CS, Woldu, G, Wondafrash, DZ, Wonde, TE, Wu, A-M, Yadollahpour, A, Jabbari, SHY, Yamada, T, Yaya, S, Yazdi-Feyzabadi, V, Yeheyis, TY, Yeshaw, Y, Yilgwan, CS, Yip, P, Yonemoto, N, Younis, MZ, Yousefi, Z, Yousefifard, M, Yousefinezhadi, T, Yu, C, Yusefzadeh, H, Zadey, S, Zahirian, Moghadam, T, Zaki, L, Zaman, SB, Zamani, M, Zamanian, M, Zandian, H, Zangeneh, A, Zarei, F, Zerfu, TA, Zhang, Y, Zhang, Z-J, Zhao, X-JG, Zhou, M, Ziapour, A, Hay, SI, Lim, SS, Mosser, JF, Local Burden of Disease Vaccine Coverage Collaborators, Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Value, Affordability and Sustainability (VALUE), Microbes in Health and Disease (MHD), HUS Comprehensive Cancer Center, Clinicum, Department of Oncology, Sbarra, Alyssa N., Rolfe, Sam, Nguyen, Jason Q., Earl, Lucas, Ahmed, MB, Mosser, Jonathan F, Collaborators, Local Burden of Disease Vaccine Coverage, Bill & Melinda Gates Foundation, Alexander von Humboldt-Stiftung, Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Universiti Sains Malaysia (Malasia), Panjab University (India), NIHR - Oxford Biomedical Research Centre (Reino Unido), Australian Research Council, Instituto de Saúde Pública da Universidade do Porto, Local Burden Dis Educ Attainment C, Local Burden of Disease Vaccine Coverage Collaborator, and Violante FS

Subjects
and promotion of well-being, Vacunación Masiva, Internationality, Disease prevention, children under 5 years old, Geographic Mapping, Rural Health, medicine.disease_cause, Cross-reactivity, 0302 clinical medicine, RA0421, Vaccination Refusal, 030212 general & internal medicine, Child, immunity patterns, Pediatric, 0303 health sciences, Public health, Multidisciplinary, biology, Vaccination, Uncertainty, IMMUNIZATION, 3142 Public health care science, environmental and occupational health, COVERAGE, 3. Good health, TIME, 3.4 Vaccines, Child, Preschool, Infectious diseases, A990 Medicine and Dentistry not elsewhere classified, Antibody, Engineering sciences. Technology, AFRICA, General Science & Technology, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), COVID-19, 610 Medicine & health, Global Vaccine Action Plan (GVAP), Local Burden of Disease Vaccine Coverage Collaborators, Article, Vaccine Related, 03 medical and health sciences, measles vaccine, Measels, Low- and middle-income countries, Local burden of disease, Clinical Research, medicine, Humans, Healthcare Disparities, Preschool, PROGRESS, 030304 developmental biology, business.industry, MORTALITY, Developed Countries, Prevention, Comment, Vacunación, Urban Health, Prevention of disease and conditions, Virology, Coronavirus, Good Health and Well Being, Cobertura de Vacunación, biology.protein, Immunization, business, Measles
Abstract

The safe, highly effective measles vaccine has been recommended globally since 1974, yet in 2017 there were more than 17 million cases of measles and 83,400 deaths in children under 5 years old, and more than 99% of both occurred in low- and middle-income countries (LMICs)1–4. Globally comparable, annual, local estimates of routine first-dose measles-containing vaccine (MCV1) coverage are critical for understanding geographically precise immunity patterns, progress towards the targets of the Global Vaccine Action Plan (GVAP), and high-risk areas amid disruptions to vaccination programmes caused by coronavirus disease 2019 (COVID-19)5–8. Here we generated annual estimates of routine childhood MCV1 coverage at 5 × 5-km2 pixel and second administrative levels from 2000 to 2019 in 101 LMICs, quantified geographical inequality and assessed vaccination status by geographical remoteness. After widespread MCV1 gains from 2000 to 2010, coverage regressed in more than half of the districts between 2010 and 2019, leaving many LMICs far from the GVAP goal of 80% coverage in all districts by 2019. MCV1 coverage was lower in rural than in urban locations, although a larger proportion of unvaccinated children overall lived in urban locations; strategies to provide essential vaccination services should address both geographical contexts. These results provide a tool for decision-makers to strengthen routine MCV1 immunization programmes and provide equitable disease protection for all children., Although progress in the coverage of routine measles vaccination in children in low- and middle-income countries was made during 2000–2019, many countries remain far from the goal of 80% coverage in all districts by 2019.

Published
2021

20. Predicting the environmental suitability for onchocerciasis in Africa as an aid to elimination planning.

Author

Cromwell E.A., Osborne J.C.P., Unnasch T.R., Basanez M., Gass K.M., Barbre K.A., Hill E., Johnson K.B., Donkers K.M., Shirude S., Schmidt C.A., Adekanmbi V., Adetokunboh O.O., Afarideh M., Ahmadpour E., Beshir Ahmed M., Yihunie Akalu T., Al-Aly Z., Alanezi F.M., Alanzi T.M., Alipour V., Andrei C.L., Ansari F., Ansha M.G., Anvari D., Yaw Appiah S.C., Arabloo J., Arnold B.F., Ausloos M., Ayanore M.A., Amin Baig A., Banach M., Barac A., Barnighausen T.W., Bayati M., Bhattacharyya K., Bhutta Z.A., Bibi S., Bijani A., Bohlouli S., Bohluli M., Brady O.J., Bragazzi N.L., Butt Z.A., Carvalho F., Chatterjee S., Chattu V.K., Chattu S.K., Cormier N.M., Dahlawi S.M.A., Damiani G., Daoud F., Darwesh A.M., Daryani A., Deribe K., Dharmaratne S.D., Diaz D., Do H.T., El Sayed Zak M., El Tantawi M., Elemineh D.A., Faraj A., Harandi M.F., Fatahi Y., Feigin V.L., Fernandes E., Foigt N.A., Foroutan M., Franklin R.C., Mohialdeen Gubari M.I., Guido D., Guo Y., Haj-Mirzaian A., Abdullah K.H., Hamidi S., Herteliu C., De Hidru H.D., Higazi T.B., Hossain N., Hosseinzadeh M., Househ M., Ilesanmi O.S., Ilic M.D., Ilic I.M., Iqbal U., Naghibi Irvani S.S., Jha R.P., Joukar F., Jozwiak J.J., Kabir Z., Kalankesh L.R., Kalhor R., Matin B.K., Karimi S.E., Kasaeian A., Kavetskyy T., Kayode G.A., Karyani A.K., Kelbore A.G., Keramati M., Khalilov R., Khan E.A., Nuruzzaman Khan M.N., Khatab K., Khater M.M., Kianipour N., Kibret K.T., Kim Y.J., Kosen S., Krohn K.J., Kusuma D., Vecchia C.L., Lansingh V.C., Lee P.H., Legrand K.E., Li S., Longbottom J., Abd El Razek H.M., Abd El Razek M.M., Maleki A., Mamun A.A., Manafi A., Manafi N., Mansournia M.A., Martins-Melo F.R., Mazidi M., McAlinden C., Meharie B.G., Mendoza W., Mengesha E.W., Mengistu D.T., Mereta S.T., Mestrovic T., Miller T.R., Miri M., Moghadaszadeh M., Hafshejani A.M., Mohammadpourhodki R., Mohammed S., Moradi M., Moradzadeh R., Moraga P., Mosser J.F., Naderi M., Nagarajan A.J., Naik G., Negoi I., Nguyen C.T., Nguyen H.L.T., Nguyen T.H., Nikbakhsh R., Oancea B., Olagunju T.O., Olagunju A.T., Bali A.O., Onwujekwe O.E., Pana A., Pourjafar H., Rahim F., Ur Rahman M.H., Rathi P., Rawaf S., Rawaf D.L., Rawassizadeh R., Resnikoff S., Reta M.A., Rezapour A., Rubagotti E., Rubino S., Sadeghi E., Saghafipour A., Sajadi S.M., Samy A.M., Sarmiento-Suarez R., Sawhney M., Schipp M.F., Shaheen A.A., Shaikh M.A., Shamsizadeh M., Sharafi K., Sheikh A., Kumar Shetty B.S., Shin J.I., Shivakumar K.M., Simonetti B., Singh J.A., Skiadaresi E., Soheili A., Soltani S., Spurlock E.E., Sufiyan M.B., Tabuchi T., Tapak L., Thompson R.L., Thomson A.J., Traini E., Tran B.X., Ullah I., Ullah S., Uneke C.J., Unnikrishnan B., Uthman O.A., Melchers N.V.S.V., Violante F.S., Wolde H.F., Wonde T.E., Yamada T., Yaya S., Yazdi Feyzabadi V., Yip P., Yonemoto N., Yousof H.-A.S.A., Yu C., Yu Y., Yusefzadeh H., Zaki L., Zaman S.B., Zamanian M., Zhang Z.-J., Zhang Y., Ziapour A., Hay S.I., Pigott D.M., Cromwell E.A., Osborne J.C.P., Unnasch T.R., Basanez M., Gass K.M., Barbre K.A., Hill E., Johnson K.B., Donkers K.M., Shirude S., Schmidt C.A., Adekanmbi V., Adetokunboh O.O., Afarideh M., Ahmadpour E., Beshir Ahmed M., Yihunie Akalu T., Al-Aly Z., Alanezi F.M., Alanzi T.M., Alipour V., Andrei C.L., Ansari F., Ansha M.G., Anvari D., Yaw Appiah S.C., Arabloo J., Arnold B.F., Ausloos M., Ayanore M.A., Amin Baig A., Banach M., Barac A., Barnighausen T.W., Bayati M., Bhattacharyya K., Bhutta Z.A., Bibi S., Bijani A., Bohlouli S., Bohluli M., Brady O.J., Bragazzi N.L., Butt Z.A., Carvalho F., Chatterjee S., Chattu V.K., Chattu S.K., Cormier N.M., Dahlawi S.M.A., Damiani G., Daoud F., Darwesh A.M., Daryani A., Deribe K., Dharmaratne S.D., Diaz D., Do H.T., El Sayed Zak M., El Tantawi M., Elemineh D.A., Faraj A., Harandi M.F., Fatahi Y., Feigin V.L., Fernandes E., Foigt N.A., Foroutan M., Franklin R.C., Mohialdeen Gubari M.I., Guido D., Guo Y., Haj-Mirzaian A., Abdullah K.H., Hamidi S., Herteliu C., De Hidru H.D., Higazi T.B., Hossain N., Hosseinzadeh M., Househ M., Ilesanmi O.S., Ilic M.D., Ilic I.M., Iqbal U., Naghibi Irvani S.S., Jha R.P., Joukar F., Jozwiak J.J., Kabir Z., Kalankesh L.R., Kalhor R., Matin B.K., Karimi S.E., Kasaeian A., Kavetskyy T., Kayode G.A., Karyani A.K., Kelbore A.G., Keramati M., Khalilov R., Khan E.A., Nuruzzaman Khan M.N., Khatab K., Khater M.M., Kianipour N., Kibret K.T., Kim Y.J., Kosen S., Krohn K.J., Kusuma D., Vecchia C.L., Lansingh V.C., Lee P.H., Legrand K.E., Li S., Longbottom J., Abd El Razek H.M., Abd El Razek M.M., Maleki A., Mamun A.A., Manafi A., Manafi N., Mansournia M.A., Martins-Melo F.R., Mazidi M., McAlinden C., Meharie B.G., Mendoza W., Mengesha E.W., Mengistu D.T., Mereta S.T., Mestrovic T., Miller T.R., Miri M., Moghadaszadeh M., Hafshejani A.M., Mohammadpourhodki R., Mohammed S., Moradi M., Moradzadeh R., Moraga P., Mosser J.F., Naderi M., Nagarajan A.J., Naik G., Negoi I., Nguyen C.T., Nguyen H.L.T., Nguyen T.H., Nikbakhsh R., Oancea B., Olagunju T.O., Olagunju A.T., Bali A.O., Onwujekwe O.E., Pana A., Pourjafar H., Rahim F., Ur Rahman M.H., Rathi P., Rawaf S., Rawaf D.L., Rawassizadeh R., Resnikoff S., Reta M.A., Rezapour A., Rubagotti E., Rubino S., Sadeghi E., Saghafipour A., Sajadi S.M., Samy A.M., Sarmiento-Suarez R., Sawhney M., Schipp M.F., Shaheen A.A., Shaikh M.A., Shamsizadeh M., Sharafi K., Sheikh A., Kumar Shetty B.S., Shin J.I., Shivakumar K.M., Simonetti B., Singh J.A., Skiadaresi E., Soheili A., Soltani S., Spurlock E.E., Sufiyan M.B., Tabuchi T., Tapak L., Thompson R.L., Thomson A.J., Traini E., Tran B.X., Ullah I., Ullah S., Uneke C.J., Unnikrishnan B., Uthman O.A., Melchers N.V.S.V., Violante F.S., Wolde H.F., Wonde T.E., Yamada T., Yaya S., Yazdi Feyzabadi V., Yip P., Yonemoto N., Yousof H.-A.S.A., Yu C., Yu Y., Yusefzadeh H., Zaki L., Zaman S.B., Zamanian M., Zhang Z.-J., Zhang Y., Ziapour A., Hay S.I., and Pigott D.M.

Abstract

Recent evidence suggests that, in some foci, elimination of onchocerciasis from Africa may be feasible with mass drug administration (MDA) of ivermectin. To achieve continental elimination of transmission, mapping surveys will need to be conducted across all implementation units (IUs) for which endemicity status is currently unknown. Using boosted regression tree models with optimised hyperparameter selection, we estimated environmental suitability for onchocerciasis at the 5 x 5-km resolution across Africa. In order to classify IUs that include locations that are environmentally suitable, we used receiver operating characteristic (ROC) analysis to identify an optimal threshold for suitability concordant with locations where onchocerciasis has been previously detected. This threshold value was then used to classify IUs (more suitable or less suitable) based on the location within the IU with the largest mean prediction. Mean estimates of environmental suitability suggest large areas across West and Central Africa, as well as focal areas of East Africa, are suitable for onchocerciasis transmission, consistent with the presence of current control and elimination of transmission efforts. The ROC analysis identified a mean environmental suitability index of 0.71 as a threshold to classify based on the location with the largest mean prediction within the IU. Of the IUs considered for mapping surveys, 50.2% exceed this threshold for suitability in at least one 5x5-km location. The formidable scale of data collection required to map onchocerciasis endemicity across the African continent presents an opportunity to use spatial data to identify areas likely to be suitable for onchocerciasis transmission. National onchocerciasis elimination programmes may wish to consider prioritising these IUs for mapping surveys as human resources, laboratory capacity, and programmatic schedules may constrain survey implementation, and possibly delaying MDA initiation in areas that would ult

Published
2021

21. Mapping routine measles vaccination in low- and middle-income countries.

Author

Sambala E.Z., Waheed Y., Wakefield J., Wang Y., Wang Y.-P., Weldesamuel G.T., Werdecker A., Westerman R., Wiangkham T., Wiens K.E., Wiysonge C.S., Woldu G., Wondafrash D.Z., Wonde T.E., Wu A.-M., Yadollahpour A., Jabbari S.H.Y., Yamada T., Yaya S., Yazdi-Feyzabadi V., Yeheyis T.Y., Yeshaw Y., Yilgwan C.S., Yip P., Yonemoto N., Younis M.Z., Yousefi Z., Yousefifard M., Yousefinezhadi T., Yu C., Yusefzadeh H., Zadey S., Zahirian Moghadam T., Zaki L., Zaman S.B., Zamani M., Zamanian M., Zandian H., Zangeneh A., Zarei F., Zerfu T.A., Zhang Y., Zhang Z.-J., Zhao X.-J.G., Zhou M., Ziapour A., Hay S.I., Lim S.S., Mosser J.F., Biswas A., Sbarra A.N., Rolfe S., Nguyen J.Q., Earl L., Galles N.C., Marks A., Abbas K.M., Abbasi-Kangevari M., Abbastabar H., Abd-Allah F., Abdelalim A., Abdollahi M., Abegaz K.H., Abiy H.A.A., Abolhassani H., Abreu L.G., Abrigo M.R.M., Abushouk A.I., Accrombessi M.M.K., Adabi M., Adebayo O.M., Adekanmbi V., Adetokunboh O.O., Adham D., Afarideh M., Aghaali M., Ahmad T., Ahmadi R., Ahmadi K., Ahmed M.B., Alanezi F.M., Alanzi T.M., Alcalde-Rabanal J.E., Alemnew B.T., Ali B.A., Ali M., Alijanzadeh M., Alinia C., Alipoor R., Alipour V., Alizade H., Aljunid S.M., Almasi A., Almasi-Hashiani A., Al-Mekhlafi H.M., Altirkawi K.A., Amare B., Amini S., Amini-Rarani M., Amiri F., Amit A.M.L., Amugsi D.A., Ancuceanu R., Andrei C.L., Anjomshoa M., Ansari F., Ansari-Moghaddam A., Ansha M.G., Antonio C.A.T., Antriyandarti E., Anvari D., Arabloo J., Arab-Zozani M., Aremu O., Armoon B., Aryal K.K., Arzani A., Asadi-Aliabadi M., Asgari S., Atafar Z., Ausloos M., Awoke N., Quintanilla B.P.A., Ayanore M.A., Aynalem Y.A., Azadmehr A., Azari S., Babaee E., Badawi A., Badiye A.D., Bahrami M.A., Baig A.A., Bakhtiari A., Balakrishnan S., Banach M., Banik P.C., Barac A., Baradaran-Seyed Z., Baraki A.G., Basu S., Bayati M., Bayou Y.T., Bedi N., Behzadifar M., Bell M.L., Berbada D.A., Berhe K., Bhattarai S., Bhutta Z.A., Bijani A., Birhanu M., Bisanzio D., Bohlouli S., Bolla S.R., Borzouei S., Brady O.J., Bragazzi N.L., Briko A.N., Briko N.I., Nagaraja S.B., Butt Z.A., Camera L.A., Campos-Nonato I.R., Car J., Cardenas R., Carvalho F., Castaldelli-Maia J.M., Castro F., Chattu V.K., Chehrazi M., Chin K.L., Chu D.-T., Cook A.J., Cormier N.M., Cunningham B., Dahlawi S.M.A., Damiani G., Dandona R., Dandona L., Danovaro M.C., Dansereau E., Daoud F., Darwesh A.M., Darwish A.H., Das J.K., Weaver N.D., De Neve J.-W., Demeke F.M., Demis A.B., Denova-Gutierrez E., Desalew A., Deshpande A., Desta D.M., Dharmaratne S.D., Dhungana G.P., Dianatinasab M., Diaz D., Dipeolu I.O., Djalalinia S., Do H.T., Dorostkar F., Doshmangir L., Doyle K.E., Dunachie S.J., Duraes A.R., Kalan M.E., Leylabadlo H.E., Edinur H.A., Effiong A., Eftekhari A., El Sayed I., El Sayed Zaki M., Elema T.B., Elhabashy H.R., El-Jaafary S.I., Elsharkawy A., Emamian M.H., Enany S., Eshrati B., Eskandari K., Eskandarieh S., Esmaeilnejad S., Esmaeilzadeh F., Esteghamati A., Etisso A.E., Farahmand M., Faraon E.J.A., Fareed M., Faridnia R., Farioli A., Farzadfar F., Fattahi N., Fazlzadeh M., Fereshtehnejad S.-M., Fernandes E., Filip I., Fischer F., Foigt N.A., Folayan M.O., Foroutan M., Fukumoto T., Fullman N., Gad M.M., Geberemariyam B.S., Gebrehiwot T.T., Gebrehiwot A.M., Gebremariam K.T., Gebremedhin K.B., Gebremeskel G.G., Gebreslassie A.A., Gedefaw G.A., Gezae K.E., Ghadiri K., Ghaffari R., Ghaffarifar F., Ghajarzadeh M., Gheshlagh R.G., Ghashghaee A., Ghiasvand H., Gholamian A., Gilani S.A., Gill P.S., Girmay A., Gomes N.G.M., Gopalani S.V., Goulart B.N.G., Grada A., Guimaraes R.A., Guo Y., Gupta R., Hafezi-Nejad N., Haj-Mirzaian A., Handiso D.W., Hanif A., Haririan H., Hasaballah A.I., Hasan M.M., Hasanpoor E., Hasanzadeh A., Hassanipour S., Hassankhani H., Heidari-Soureshjani R., Henry N.J., Herteliu C., Heydarpour F., Hollerich G.I., Rad E.H., Hoogar P., Hossain N., Hosseini M., Hosseinzadeh M., Househ M., Hu G., Huda T.M., Humayun A., Ibitoye S.E., Ikilezi G., Ilesanmi O.S., Ilic I.M., Ilic M.D., Imani-Nasab M.H., Inbaraj L.R., Iqbal U., Irvani S.S.N., Islam S.M.S., Islam M.M., Iwu C.J., Iwu C.C.D., Jadidi-Niaragh F., Jafarinia M., Jahanmehr N., Jakovljevic M., Jalali A., Jalilian F., Javidnia J., Jenabi E., Jha V., Ji J.S., John O., Johnson K.B., Joukar F., Jozwiak J.J., Kabir Z., Kabir A., Kalani H., Kalankesh L.R., Kalhor R., Kamal Z., Kanchan T., Kapoor N., Karami M., Matin B.K., Karch A., Karimi S.E., Kayode G.A., Karyani A.K., Keiyoro P.N., Khader Y.S., Khafaie M.A., Khammarnia M., Khan M.S., Khan E.A., Khan J., Khan M.N., Khatab K., Khater M.M., Khatib M.N., Khayamzadeh M., Khazaei M., Khazaei S., Khosravi A., Khubchandani J., Kianipour N., Kim Y.J., Kimokoti R.W., Kinyoki D.K., Kisa A., Kisa S., Kolola T., Komaki H., Kosen S., Koul P.A., Koyanagi A., Kraemer M.U.G., Krishan K., Kuate Defo B., Kumar M., Kumar P., Kumar G.A., Kusuma D., La Vecchia C., Lacey B., Lad S.D., Lal D.K., Lam F., Lami F.H., Lansingh V.C., Larson H.J., Lasrado S., Lee S.W.H., Lee P.H., LeGrand K.E., Lenjebo T.L., Li S., Liang X., Liu P.Y., Lopukhov P.D., Machado D.B., Mahasha P.W., Mahdavi M.M., Maheri M., Mahotra N.B., Maled V., Maleki S., Malik M.A., Malta D.C., Mansour-Ghanaei F., Mansouri B., Mansourian M., Mansournia M.A., Martins-Melo F.R., Masaka A., Mayala B.K., Mehndiratta M.M., Mehri F., Mehta K.M., Memiah P.T.N., Mendoza W., Menezes R.G., Mengesha M.B., Mengesha E.W., Mestrovic T., Mihretie K.M., Miller-Petrie M.K., Mills E.J., Milne G.J., Mirabi P., Mirrakhimov E.M., Mirzaei R., Mirzaei M., Mirzaei H.R., Mirzaei H., Mirzaei-Alavijeh M., Moazen B., Moghadaszadeh M., Mohamadi E., Mohammad D.K., Mohammad Y., Mohammad K.A., Mohammad Gholi Mezerji N., Mohammadbeigi A., Mohammadian-Hafshejani A., Mohammadpourhodki R., Mohammed S., Mohammed A.S., Mohammed H., Mohebi F., Mokdad A.H., Monasta L., Moosavi M.A., Moosazadeh M., Moradi G., Moradi M., Moradi-Joo M., Moradi-Lakeh M., Moradzadeh R., Moraga P., Mosapour A., Mouodi S., Mousavi S.M., Khaneghah A.M., Mueller U.O., Muluneh A.G., Munro S.B., Murray C.J.L., Murthy G.V.S., Muthupandian S., Naderi M., Nagarajan A.J., Naghavi M., Nangia V., Nansseu J.R., Nayak V.C., Nazari J., Ndwandwe D.E., Negoi I., Ngunjiri J.W., Nguyen H.L.T., Nguyen C.T.K., Nguyen T.H., Nigatu Y.T., Nikbakhsh R., Nikfar S., Nikpoor A.R., Ningrum D.N.A., Nnaji C.A., Oh I.-H., Oladnabi M., Olagunju A.T., Olusanya J.O., Olusanya B.O., Bali A.O., Omer M.O., Onwujekwe O.E., Osgood-Zimmerman A.E., Owolabi M.O., P A M., Padubidri J.R., Pakshir K., Pana A., Pandey A., Pando-Robles V., Pashaei T., Pasupula D.K., Paternina-Caicedo A.J., Patton G.C., Pazoki Toroudi H., Pepito V.C.F., Pescarini J.M., Pigott D.M., Pilgrim T., Pirsaheb M., Poljak M., Postma M.J., Pourjafar H., Pourmalek F., Pourmirza Kalhori R., Prada S.I., Prakash S., Quazi Syed Z., Quintana H., Rabiee N., Rabiee M., Radfar A., Rafiei A., Rahim F., Rajati F., Rameto M.A., Ramezanzadeh K., Ranabhat C.L., Rao S.J., Rasella D., Rastogi P., Rathi P., Rawaf S., Rawaf D.L., Rawal L., Rawassizadeh R., Rawat R., Renjith V., Renzaho A.M.N., Reshmi B., Reta M.A., Rezaei N., Rezai M.S., Rezapour A., Riahi S.M., Ribeiro A.I., Rickard J., Rios-Blancas M., Rios-Gonzalez C.M., Roever L., Rostamian M., Rubino S., Rwegerera G.M., Saad A.M., Saadatagah S., Sabour S., Sadeghi E., Moghaddam S.S., Saeidi S., Sagar R., Sahebkar A., Sahraian M.A., Sajadi S.M., Salahshoor M.R., Salam N., Salem H., Salem M.R., Salomon J.A., Kafil H.S., Samy A.M., Saraswathy S.Y.I., Sarmiento-Suarez R., Saroshe S., Sartorius B., Sarveazad A., Sathian B., Sathish T., Schaeffer L.E., Schwebel D.C., Senthilkumaran S., Shabaninejad H., Shahabi S., Shaheen A.A., Shaikh M.A., Shalash A.S., Shams-Beyranvand M., Shamsi M.B., Shamsizadeh M., Sharafi K., Sharifi H., Sheikh A., Sheikhtaheri A., Shetty R.S., Shiferaw W.S., Shigematsu M., Shin J.I., Shirkoohi R., Siabani S., Siddiqi T.J., Silverberg J.I.S., Simonetti B., Singh J.A., Sinha D.N., Sinke A.H., Soheili A., Sokhan A., Soltani S., Soofi M., Sorrie M.B., Soyiri I.N., Spotin A., Spurlock E.E., Sreeramareddy C.T., Sudaryanto A., Sufiyan M.B., Suleria H.A.R., Abdulkader R.S., Taherkhani A., Tapak L., Taveira N., Taymoori P., Tefera Y.M., Tehrani-Banihashemi A., Teklehaimanot B.F., Tekulu G.H., Tesfay B.E., Tessema Z.T., Tessema B., Thankappan K.R., Tohidinik H.R., Topor-Madry R., Tovani-Palone M.R., Tran B.X., Uddin R., Ullah I., Umeokonkwo C.D., Unnikrishnan B., Upadhyay E., Usman M.S., Vaezi M., Valadan Tahbaz S., Valdez P.R., Vasseghian Y., Veisani Y., Violante F.S., Vollmer S., Sambala E.Z., Waheed Y., Wakefield J., Wang Y., Wang Y.-P., Weldesamuel G.T., Werdecker A., Westerman R., Wiangkham T., Wiens K.E., Wiysonge C.S., Woldu G., Wondafrash D.Z., Wonde T.E., Wu A.-M., Yadollahpour A., Jabbari S.H.Y., Yamada T., Yaya S., Yazdi-Feyzabadi V., Yeheyis T.Y., Yeshaw Y., Yilgwan C.S., Yip P., Yonemoto N., Younis M.Z., Yousefi Z., Yousefifard M., Yousefinezhadi T., Yu C., Yusefzadeh H., Zadey S., Zahirian Moghadam T., Zaki L., Zaman S.B., Zamani M., Zamanian M., Zandian H., Zangeneh A., Zarei F., Zerfu T.A., Zhang Y., Zhang Z.-J., Zhao X.-J.G., Zhou M., Ziapour A., Hay S.I., Lim S.S., Mosser J.F., Biswas A., Sbarra A.N., Rolfe S., Nguyen J.Q., Earl L., Galles N.C., Marks A., Abbas K.M., Abbasi-Kangevari M., Abbastabar H., Abd-Allah F., Abdelalim A., Abdollahi M., Abegaz K.H., Abiy H.A.A., Abolhassani H., Abreu L.G., Abrigo M.R.M., Abushouk A.I., Accrombessi M.M.K., Adabi M., Adebayo O.M., Adekanmbi V., Adetokunboh O.O., Adham D., Afarideh M., Aghaali M., Ahmad T., Ahmadi R., Ahmadi K., Ahmed M.B., Alanezi F.M., Alanzi T.M., Alcalde-Rabanal J.E., Alemnew B.T., Ali B.A., Ali M., Alijanzadeh M., Alinia C., Alipoor R., Alipour V., Alizade H., Aljunid S.M., Almasi A., Almasi-Hashiani A., Al-Mekhlafi H.M., Altirkawi K.A., Amare B., Amini S., Amini-Rarani M., Amiri F., Amit A.M.L., Amugsi D.A., Ancuceanu R., Andrei C.L., Anjomshoa M., Ansari F., Ansari-Moghaddam A., Ansha M.G., Antonio C.A.T., Antriyandarti E., Anvari D., Arabloo J., Arab-Zozani M., Aremu O., Armoon B., Aryal K.K., Arzani A., Asadi-Aliabadi M., Asgari S., Atafar Z., Ausloos M., Awoke N., Quintanilla B.P.A., Ayanore M.A., Aynalem Y.A., Azadmehr A., Azari S., Babaee E., Badawi A., Badiye A.D., Bahrami M.A., Baig A.A., Bakhtiari A., Balakrishnan S., Banach M., Banik P.C., Barac A., Baradaran-Seyed Z., Baraki A.G., Basu S., Bayati M., Bayou Y.T., Bedi N., Behzadifar M., Bell M.L., Berbada D.A., Berhe K., Bhattarai S., Bhutta Z.A., Bijani A., Birhanu M., Bisanzio D., Bohlouli S., Bolla S.R., Borzouei S., Brady O.J., Bragazzi N.L., Briko A.N., Briko N.I., Nagaraja S.B., Butt Z.A., Camera L.A., Campos-Nonato I.R., Car J., Cardenas R., Carvalho F., Castaldelli-Maia J.M., Castro F., Chattu V.K., Chehrazi M., Chin K.L., Chu D.-T., Cook A.J., Cormier N.M., Cunningham B., Dahlawi S.M.A., Damiani G., Dandona R., Dandona L., Danovaro M.C., Dansereau E., Daoud F., Darwesh A.M., Darwish A.H., Das J.K., Weaver N.D., De Neve J.-W., Demeke F.M., Demis A.B., Denova-Gutierrez E., Desalew A., Deshpande A., Desta D.M., Dharmaratne S.D., Dhungana G.P., Dianatinasab M., Diaz D., Dipeolu I.O., Djalalinia S., Do H.T., Dorostkar F., Doshmangir L., Doyle K.E., Dunachie S.J., Duraes A.R., Kalan M.E., Leylabadlo H.E., Edinur H.A., Effiong A., Eftekhari A., El Sayed I., El Sayed Zaki M., Elema T.B., Elhabashy H.R., El-Jaafary S.I., Elsharkawy A., Emamian M.H., Enany S., Eshrati B., Eskandari K., Eskandarieh S., Esmaeilnejad S., Esmaeilzadeh F., Esteghamati A., Etisso A.E., Farahmand M., Faraon E.J.A., Fareed M., Faridnia R., Farioli A., Farzadfar F., Fattahi N., Fazlzadeh M., Fereshtehnejad S.-M., Fernandes E., Filip I., Fischer F., Foigt N.A., Folayan M.O., Foroutan M., Fukumoto T., Fullman N., Gad M.M., Geberemariyam B.S., Gebrehiwot T.T., Gebrehiwot A.M., Gebremariam K.T., Gebremedhin K.B., Gebremeskel G.G., Gebreslassie A.A., Gedefaw G.A., Gezae K.E., Ghadiri K., Ghaffari R., Ghaffarifar F., Ghajarzadeh M., Gheshlagh R.G., 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G.A., Karyani A.K., Keiyoro P.N., Khader Y.S., Khafaie M.A., Khammarnia M., Khan M.S., Khan E.A., Khan J., Khan M.N., Khatab K., Khater M.M., Khatib M.N., Khayamzadeh M., Khazaei M., Khazaei S., Khosravi A., Khubchandani J., Kianipour N., Kim Y.J., Kimokoti R.W., Kinyoki D.K., Kisa A., Kisa S., Kolola T., Komaki H., Kosen S., Koul P.A., Koyanagi A., Kraemer M.U.G., Krishan K., Kuate Defo B., Kumar M., Kumar P., Kumar G.A., Kusuma D., La Vecchia C., Lacey B., Lad S.D., Lal D.K., Lam F., Lami F.H., Lansingh V.C., Larson H.J., Lasrado S., Lee S.W.H., Lee P.H., LeGrand K.E., Lenjebo T.L., Li S., Liang X., Liu P.Y., Lopukhov P.D., Machado D.B., Mahasha P.W., Mahdavi M.M., Maheri M., Mahotra N.B., Maled V., Maleki S., Malik M.A., Malta D.C., Mansour-Ghanaei F., Mansouri B., Mansourian M., Mansournia M.A., Martins-Melo F.R., Masaka A., Mayala B.K., Mehndiratta M.M., Mehri F., Mehta K.M., Memiah P.T.N., Mendoza W., Menezes R.G., Mengesha M.B., Mengesha E.W., Mestrovic T., Mihretie K.M., Miller-Petrie M.K., Mills E.J., Milne G.J., Mirabi P., Mirrakhimov E.M., Mirzaei R., Mirzaei M., Mirzaei H.R., Mirzaei H., Mirzaei-Alavijeh M., Moazen B., Moghadaszadeh M., Mohamadi E., Mohammad D.K., Mohammad Y., Mohammad K.A., Mohammad Gholi Mezerji N., Mohammadbeigi A., Mohammadian-Hafshejani A., Mohammadpourhodki R., Mohammed S., Mohammed A.S., Mohammed H., Mohebi F., Mokdad A.H., Monasta L., Moosavi M.A., Moosazadeh M., Moradi G., Moradi M., Moradi-Joo M., Moradi-Lakeh M., Moradzadeh R., Moraga P., Mosapour A., Mouodi S., Mousavi S.M., Khaneghah A.M., Mueller U.O., Muluneh A.G., Munro S.B., Murray C.J.L., Murthy G.V.S., Muthupandian S., Naderi M., Nagarajan A.J., Naghavi M., Nangia V., Nansseu J.R., Nayak V.C., Nazari J., Ndwandwe D.E., Negoi I., Ngunjiri J.W., Nguyen H.L.T., Nguyen C.T.K., Nguyen T.H., Nigatu Y.T., Nikbakhsh R., Nikfar S., Nikpoor A.R., Ningrum D.N.A., Nnaji C.A., Oh I.-H., Oladnabi M., Olagunju A.T., Olusanya J.O., Olusanya B.O., Bali A.O., Omer M.O., Onwujekwe 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Upadhyay E., Usman M.S., Vaezi M., Valadan Tahbaz S., Valdez P.R., Vasseghian Y., Veisani Y., Violante F.S., and Vollmer S.

Abstract

The safe, highly effective measles vaccine has been recommended globally since 1974, yet in 2017 there were more than 17 million cases of measles and 83,400 deaths in children under 5 years old, and more than 99% of both occurred in low- and middle-income countries (LMICs)1-4. Globally comparable, annual, local estimates of routine first-dose measles-containing vaccine (MCV1) coverage are critical for understanding geographically precise immunity patterns, progress towards the targets of the Global Vaccine Action Plan (GVAP), and high-risk areas amid disruptions to vaccination programmes caused by coronavirus disease 2019 (COVID-19)5-8. Here we generated annual estimates of routine childhood MCV1 coverage at 5 x 5-km2 pixel and second administrative levels from 2000 to 2019 in 101 LMICs, quantified geographical inequality and assessed vaccination status by geographical remoteness. After widespread MCV1 gains from 2000 to 2010, coverage regressed in more than half of the districts between 2010 and 2019, leaving many LMICs far from the GVAP goal of 80% coverage in all districts by 2019. MCV1 coverage was lower in rural than in urban locations, although a larger proportion of unvaccinated children overall lived in urban locations; strategies to provide essential vaccination services should address both geographical contexts. These results provide a tool for decision-makers to strengthen routine MCV1 immunization programmes and provide equitable disease protection for all children.Copyright © 2020, The Author(s).

Published
2021

22. SipA, SopA, SopB, SopD and SopE2 effector proteins of Salmonella enterica serovar Typhimurium are synthesized at late stages of infection in mice

Author

Giacomodonato, M.N., Uzzau, S., Bacciu, D., Caccuri, R., Sarnacki, S.H., Rubino, S., and Cerquetti, M.C.

Subjects
Salmonella typhimurium -- Research, Virulence (Microbiology) -- Research, Biological sciences
Abstract

Salmonella pathogenicity island (SPI)-1 is essential for invasion of non-phagocytic cells, whereas SPI-2 is required for intracellular survival and proliferation in phagocytes. Some SPI-1 effectors, however, are induced upon invasion of both phagocytic and non-phagocytic cells, suggesting that they may also be required post-invasion. In the present work, the presence was analysed of SipA, SopA, SopB, SopD and SopE2 effector proteins of Salmonella enterica serovar Typhimurium in vitro and in vivo during murine salmonellosis. Tagged (3 x FLAG) strains of S. enterica serovar Typhimurium were inoculated intraperitoneally or intragastrically to BALB/c mice and recovered from the spleen and mesenteric lymph nodes of moribund mice. Tagged proteins were detected by SDS-PAGE and immunoblotting with anti-FLAG antibodies. In vitro experiments showed that SPI-1 effector proteins SipA, SopA, SopB, SopD and SopE2 were secreted under SPI-1 conditions. Interestingly, it was found that S. enterica serovar Typhimurium continued to synthesize SipA, SopB, SopD and SopE2 in colonized organs for several days, regardless of the route of inoculation. Together, these results indicate that SPI-1 effector proteins may participate in the late stages of Salmonella infection in mice.

Published
2007

23. Mapping geographical inequalities in oral rehydration therapy coverage in low-income and middle-income countries, 2000-17.

Author

Sathish T., Tesfay B.E., Tesfay F.H., Tessema B., Tessema Z.T., Thankappan K.R., Thomas N., Toma A., Topor-Madry R., Tovani-Palone M.R., Traini E., Tran B.X., Tran K.B., Ullah I., Unnikrishnan B., Usman M.S., Uzochukwu B.S.C., Valdez P.R., Varughese S., Violante F.S., Vollmer S., Whawariat F.G., Waheed Y., Wallin M.T., Wang Y., Wang Y.-P., Weaver M., Weji B.G., Weldesamuel G.T., Welgan C.A., Werdecker A., Westerman R., Wiangkham T., Wiysonge C.S., Wolde H.F., Wondafrash D.Z., Wonde T.E., Worku G.T., Wu A.-M., Xu G., Yadollahpour A., Yahyazadeh Jabbari S.H., Yamada T., Yatsuya H., Yeshaneh A., Yilgwan C.S., Yilma M.T., Yip P., Yisma E., Yonemoto N., Yoon S.-J., Younis M.Z., Yousefifard M., Yousof H.-A.S.A., Yu C., Yusefzadeh H., Zadey S., Zaidi Z., Zaman S.B., Zamani M., Zandian H., Zepro N.B., Zerfu T.A., Zhang Y., Zhao X.-J.G., Ziapour A., Zodpey S., Zuniga Y.M.H., Hay S.I., Reiner R.C., Singh A., Wiens K.E., Lindstedt P.A., Blacker B.F., Johnson K.B., Baumann M.M., Schaeffer L.E., Abbastabar H., Abd-Allah F., Abdelalim A., Abdollahpour I., Abegaz K.H., Abejie A.N., Abreu L.G., Abrigo M.R.M., Abualhasan A., Accrombessi M.M.K., Acharya D., Adabi M., Adamu A.A., Adebayo O.M., Adedoyin R.A., Adekanmbi V., Adetokunboh O.O., Adhena B.M., Afarideh M., Ahmad S., Ahmadi K., Ahmed A.E., Ahmed M.B., Ahmed R., Akalu T.Y., Alahdab F., Al-Aly Z., Alam N., Alam S., Alamene G.M., Alanzi T.M., Alcalde-Rabanal J.E., Ali B.A., Alijanzadeh M., Alipour V., Aljunid S.M., Almasi A., Almasi-Hashiani A., Al-Mekhlafi H.M., Altirkawi K.A., Alvis-Guzman N., Alvis-Zakzuk N.J., Amini S., Amit A.M.L., Andrei C.L., Anjomshoa M., Anoushiravani A., Ansari F., Antonio C.A.T., Antony B., Antriyandarti E., Arabloo J., Aref H.M.A., Aremu O., Armoon B., Arora A., Aryal K.K., Arzani A., Asadi-Aliabadi M., Atalay H.T., Athari S.S., Athari S.M., Atre S.R., Ausloos M., Awoke N., Ayala Quintanilla B.P., Ayano G., Ayanore M.A., Aynalem Y.A., Azari S., Azzopardi P.S., Babaee E., Babalola T.K., Badawi A., Bairwa M., Bakkannavar S.M., Balakrishnan S., Bali A.G., Banach M., Banoub J.A.M., Barac A., Barnighausen T.W., Basaleem H., Basu S., Bay V.D., Bayati M., Baye E., Bedi N., Beheshti M., Behzadifar M., Bekele B.B., Belayneh Y.M., Bell M.L., Bennett D.A., Berbada D.A., Bernstein R.S., Bhat A.G., Bhattacharyya K., Bhattarai S., Bhaumik S., Bhutta Z.A., Bijani A., Bikbov B., Birihane B.M., Biswas R.K., Bohlouli S., Bojia H.A., Boufous S., Brady O.J., Bragazzi N.L., Briko A.N., Briko N.I., Britton G.B., Burugina Nagaraja S., Busse R., Butt Z.A., Camera L.A., Campos-Nonato I.R., Cano J., Car J., Cardenas R., Carvalho F., Castaneda-Orjuela C.A., Castro F., Chanie W.F., Chatterjee P., Chattu V.K., Chichiabellu T.Y., Chin K.L., Christopher D.J., Chu D.-T., Cormier N.M., Costa V.M., Culquichicon C., Daba M.S., Damiani G., Dandona L., Dandona R., Dang A.K., Darwesh A.M., Darwish A.H., Daryani A., Das J.K., Das Gupta R.D., Dash A.P., Davey G., Davila-Cervantes C.A., Davis A.C., Davitoiu D.V., De la Hoz F.P., Demis A.B., Demissie D.B., Demissie G.D., Demoz G.T., Denova-Gutierrez E., Deribe K., Desalew A., Deshpande A., Dharmaratne S.D., Dhillon P., Dhimal M., Dhungana G.P., Diaz D., Dipeolu I.O., Djalalinia S., Doyle K.E., Dubljanin E., Duko B., Duraes A.R., Ebrahimi Kalan M., Edinur H.A., Effiong A., Eftekhari A., El Nahas N., El Sayed I., El Sayed Zaki M., El Tantawi M., Elema T.B., Elhabashy H.R., El-Jaafary S.I., Elkout H., Elsharkawy A., Elyazar I.R.F., Endalamaw A., Endalew D.A., Eskandarieh S., Esteghamati A., Esteghamati S., Etemadi A., Ezekannagha O., Fareed M., Faridnia R., Farzadfar F., Fazlzadeh M., Feigin V.L., Fereshtehnejad S.-M., Fernandes E., Filip I., Fischer F., Foigt N.A., Folayan M.O., Foroutan M., Franklin R.C., Fukumoto T., Gad M.M., Gayesa R.T., Gebre T., Gebremedhin K.B., Gebremeskel G.G., Gesesew H.A., Gezae K.E., Ghadiri K., Ghashghaee A., Ghimire P.R., Gill P.S., Gill T.K., Ginindza T.G., Gomes N.G., Gopalani S.V., Goulart A.C., Goulart B.N.G., Grada A., Gubari M.I.M., Gugnani H.C., Guido D., Guimaraes R.A., Guo Y., Gupta R., Hafezi-Nejad N., Haile D.H., Hailu G.B., Haj-Mirzaian A., Hamadeh R.R., Hamidi S., Handiso D.W., Haririan H., Hariyani N., Hasaballah A.I., Hasan M.M., Hasanpoor E., Hasanzadeh A., Hassankhani H., Hassen H.Y., Hegazy M.I., Heibati B., Heidari B., Hendrie D., Henry N.J., Herteliu C., Heydarpour F., Hidru H.D.D., Hird T.R., Hoang C.L., Homaie Rad E.H., Hoogar P., Hoseini M., Hossain N., Hosseini M., Hosseinzadeh M., Househ M., Hsairi M., Hu G., Hussen M.M., Ibitoye S.E., Igumbor E.U., Ilesanmi O.S., Ilic M.D., Imani-Nasab M.H., Iqbal U., Irvani S.S.N., Islam S.M.S., Iwu C.J., Izadi N., Jaca A., Jahanmehr N., Jakovljevic M., Jalali A., Jayatilleke A.U., Jha R.P., Jha V., Ji J.S., Jonas J.B., Jozwiak J.J., Kabir A., Kabir Z., Kahsay A., Kalani H., Kanchan T., Karami Matin B., Karch A., Karim M.A., Karimi-Sari Surendra Karki H., Kasaeian A., Kasahun G.G., Kasahun Y.C., Kasaye H.K., Kassa G.G., Kassa G.M., Kayode G.A., Kazemi Karyani A., Kebede M.M., Keiyoro P.N., Kelbore A.G., Kengne A.P., Ketema D.B., Khader Y.S., Khafaie M.A., Khalid N., Khalilov R., Khan E.A., Khan J., Khan M.N., Khan M.S., Khatab K., Khater A.M., Khater M.M., Khayamzadeh M., Khazaei M., Khazaei S., Khosravi M.H., Khubchandani J., Kiadaliri A., Kim Y.J., Kimokoti R.W., Kisa A., Kisa S., Kissoon N., Shivakumar K.M., Kochhar S., Kolola T., Komaki H., Kosen S., Koul P.A., Koyanagi A., Kraemer M.U.G., Krishan K., Kugbey N., Kumar G.A., Kumar M., Kumar P., Kumar V., Kusuma D., La Vecchia C., Lacey B., Lad S.D., Lal D.K., Lam F., Lami F.H., Lamichhane P., Lansingh V.C., Lasrado S., Laxmaiah A., Lee P.H., LeGrand K.E., Leili M., Lenjebo T.L., Leshargie C.T., Levine A.J., Li S., Linn S., Liu S., Lodha R., Longbottom J., Lopez J.C.F., Magdy Abd El Razek H., Magdy Abd El Razek M., Mahadeshwara Prasad DR., Mahasha P.W., Mahotra N.B., Majeed A., Malekzadeh R., Malta D.C., Mamun A.A., Manafi N., Manda A.L., Manohar N.D.D., Mansournia M.A., Mapoma C.C., Maravilla J.C., Martinez G., Martini S., Martins-Melo F.R., Masaka A., Massenburg B.B., Mathur M.R., Mayala B.K., Mazidi M., McAlinden C., Meharie B.G., Mehndiratta M.M., Mehta K.M., Mekonnen T.C., Meles G.G., Memiah P.T.N., Memish Z.A., Mendoza W., Menezes R.G., Mereta S.T., Meretoja T.J., Mestrovic T., Miazgowski B., Mihretie K.M., Miller T.R., Mini G.K., Mirrakhimov E.M., Moazen B., Mohajer B., Mohamadi-Bolbanabad A., Mohammad D.K., Mohammad K.A., Mohammad Y., Mohammad Gholi Mezerji N., Mohammadibakhsh R., Mohammadifard N., Mohammed J.A., Mohammed S., Mohebi F., Mokdad A.H., Molokhia M., Monasta L., Moodley Y., Moore C.E., Moradi G., Moradi M., Moradi-Joo M., Moradi-Lakeh M., Moraga P., Morales L., Moreno Velasquez I., Mosapour A., Mouodi S., Mousavi S.M., Mozaffor M., Muchie K.F., Mulaw G.F., Munro S.B., Muriithi M.K., Murray C.J., Murthy G.V.S., Musa K.I., Mustafa G., Muthupandian S., Nabhan A.F., Naderi M., Nagarajan A.J., Naidoo K.S., Naik G., Najafi F., 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D.A.S., Singh J.A., Singh N.P., Singh V., Sisay M.M., Skiadaresi E., Sobhiyeh M.R., Sokhan A., Soltani S., Somayaji R., Soofi M., Sorrie M.B., Soyiri I.N., Sreeramareddy C.T., Sudaryanto A., Sufiyan M.B., Suleria H.A.R., Sultana M., Sunguya B.F., Sykes B.L., Tabares-Seisdedos R., Tabuchi T., Tadesse D.B., Tarigan I.U., Tasew A.A., Tefera Y.M., Tekle M.G., Temsah M., Sathish T., Tesfay B.E., Tesfay F.H., Tessema B., Tessema Z.T., Thankappan K.R., Thomas N., Toma A., Topor-Madry R., Tovani-Palone M.R., Traini E., Tran B.X., Tran K.B., Ullah I., Unnikrishnan B., Usman M.S., Uzochukwu B.S.C., Valdez P.R., Varughese S., Violante F.S., Vollmer S., Whawariat F.G., Waheed Y., Wallin M.T., Wang Y., Wang Y.-P., Weaver M., Weji B.G., Weldesamuel G.T., Welgan C.A., Werdecker A., Westerman R., Wiangkham T., Wiysonge C.S., Wolde H.F., Wondafrash D.Z., Wonde T.E., Worku G.T., Wu A.-M., Xu G., Yadollahpour A., Yahyazadeh Jabbari S.H., Yamada T., Yatsuya H., Yeshaneh A., Yilgwan C.S., Yilma M.T., Yip P., Yisma E., Yonemoto N., Yoon S.-J., Younis M.Z., Yousefifard M., Yousof H.-A.S.A., Yu C., Yusefzadeh H., Zadey S., Zaidi Z., Zaman S.B., Zamani M., Zandian H., Zepro N.B., Zerfu T.A., Zhang Y., Zhao X.-J.G., Ziapour A., Zodpey S., Zuniga Y.M.H., Hay S.I., Reiner R.C., Singh A., Wiens K.E., Lindstedt P.A., Blacker B.F., Johnson K.B., Baumann M.M., Schaeffer L.E., Abbastabar H., Abd-Allah F., Abdelalim A., Abdollahpour I., Abegaz K.H., Abejie A.N., Abreu L.G., Abrigo M.R.M., Abualhasan A., Accrombessi M.M.K., Acharya D., Adabi M., Adamu A.A., Adebayo O.M., Adedoyin R.A., Adekanmbi V., Adetokunboh O.O., Adhena B.M., Afarideh M., Ahmad S., Ahmadi K., Ahmed A.E., Ahmed M.B., Ahmed R., Akalu T.Y., Alahdab F., Al-Aly Z., Alam N., Alam S., Alamene G.M., Alanzi T.M., Alcalde-Rabanal J.E., Ali B.A., Alijanzadeh M., Alipour V., Aljunid S.M., Almasi A., Almasi-Hashiani A., Al-Mekhlafi H.M., Altirkawi K.A., Alvis-Guzman N., Alvis-Zakzuk N.J., Amini S., Amit A.M.L., Andrei C.L., Anjomshoa M., Anoushiravani A., Ansari F., Antonio C.A.T., Antony B., Antriyandarti E., Arabloo J., Aref H.M.A., Aremu O., Armoon B., Arora A., Aryal K.K., Arzani A., Asadi-Aliabadi M., Atalay H.T., Athari S.S., Athari S.M., Atre S.R., Ausloos M., Awoke N., Ayala Quintanilla B.P., Ayano G., Ayanore M.A., Aynalem Y.A., Azari S., Azzopardi P.S., Babaee E., Babalola T.K., Badawi A., Bairwa M., Bakkannavar S.M., Balakrishnan S., Bali A.G., Banach M., Banoub J.A.M., Barac A., Barnighausen T.W., Basaleem H., Basu S., Bay V.D., Bayati M., Baye E., Bedi N., Beheshti M., Behzadifar M., Bekele B.B., Belayneh Y.M., Bell M.L., Bennett D.A., Berbada D.A., Bernstein R.S., Bhat A.G., Bhattacharyya K., Bhattarai S., Bhaumik S., Bhutta Z.A., Bijani A., Bikbov B., Birihane B.M., Biswas R.K., Bohlouli S., Bojia H.A., Boufous S., Brady O.J., Bragazzi N.L., Briko A.N., Briko N.I., Britton G.B., Burugina Nagaraja S., Busse R., Butt Z.A., Camera L.A., Campos-Nonato I.R., Cano J., Car J., Cardenas R., Carvalho F., Castaneda-Orjuela C.A., Castro F., Chanie W.F., Chatterjee P., Chattu V.K., Chichiabellu T.Y., Chin K.L., Christopher D.J., Chu D.-T., Cormier N.M., Costa V.M., Culquichicon C., Daba M.S., Damiani G., Dandona L., Dandona R., Dang A.K., Darwesh A.M., Darwish A.H., Daryani A., Das J.K., Das Gupta R.D., Dash A.P., Davey G., Davila-Cervantes C.A., Davis A.C., Davitoiu D.V., De la Hoz F.P., Demis A.B., Demissie D.B., Demissie G.D., Demoz G.T., Denova-Gutierrez E., Deribe K., Desalew A., Deshpande A., Dharmaratne S.D., Dhillon P., Dhimal M., Dhungana G.P., Diaz D., Dipeolu I.O., Djalalinia S., Doyle K.E., Dubljanin E., Duko B., Duraes A.R., Ebrahimi Kalan M., Edinur H.A., Effiong A., Eftekhari A., El Nahas N., El Sayed I., El Sayed Zaki M., El Tantawi M., Elema T.B., Elhabashy H.R., El-Jaafary S.I., Elkout H., Elsharkawy A., Elyazar I.R.F., Endalamaw A., Endalew D.A., Eskandarieh S., Esteghamati A., Esteghamati S., Etemadi A., Ezekannagha O., Fareed M., Faridnia R., Farzadfar F., Fazlzadeh M., Feigin V.L., Fereshtehnejad S.-M., Fernandes E., Filip I., Fischer F., Foigt N.A., Folayan M.O., Foroutan M., Franklin R.C., Fukumoto T., Gad M.M., Gayesa R.T., Gebre T., Gebremedhin K.B., Gebremeskel G.G., Gesesew H.A., Gezae K.E., Ghadiri K., Ghashghaee A., Ghimire P.R., Gill P.S., Gill T.K., Ginindza T.G., Gomes N.G., Gopalani S.V., Goulart A.C., Goulart B.N.G., Grada A., Gubari M.I.M., Gugnani H.C., Guido D., Guimaraes R.A., Guo Y., Gupta R., Hafezi-Nejad N., Haile D.H., Hailu G.B., Haj-Mirzaian A., Hamadeh R.R., Hamidi S., Handiso D.W., Haririan H., Hariyani N., Hasaballah A.I., Hasan M.M., Hasanpoor E., Hasanzadeh A., Hassankhani H., Hassen H.Y., Hegazy M.I., Heibati B., Heidari B., Hendrie D., Henry N.J., Herteliu C., Heydarpour F., Hidru H.D.D., Hird T.R., Hoang C.L., Homaie Rad E.H., Hoogar P., Hoseini M., Hossain N., Hosseini M., Hosseinzadeh M., Househ M., Hsairi M., Hu G., Hussen M.M., Ibitoye S.E., Igumbor E.U., Ilesanmi O.S., Ilic M.D., Imani-Nasab M.H., Iqbal U., Irvani S.S.N., Islam S.M.S., Iwu C.J., Izadi N., Jaca A., Jahanmehr N., Jakovljevic M., Jalali A., Jayatilleke A.U., Jha R.P., Jha V., Ji J.S., Jonas J.B., Jozwiak J.J., Kabir A., Kabir Z., Kahsay A., Kalani H., Kanchan T., Karami Matin B., Karch A., Karim M.A., Karimi-Sari Surendra Karki H., Kasaeian A., Kasahun G.G., Kasahun Y.C., Kasaye H.K., Kassa G.G., Kassa G.M., Kayode G.A., Kazemi Karyani A., Kebede M.M., Keiyoro P.N., Kelbore A.G., Kengne A.P., Ketema D.B., Khader Y.S., Khafaie M.A., Khalid N., Khalilov R., Khan E.A., Khan J., Khan M.N., Khan M.S., Khatab K., Khater A.M., Khater M.M., Khayamzadeh M., Khazaei M., Khazaei S., Khosravi M.H., Khubchandani J., Kiadaliri A., Kim Y.J., Kimokoti R.W., Kisa A., Kisa S., Kissoon N., Shivakumar K.M., Kochhar S., Kolola T., Komaki H., Kosen S., Koul P.A., Koyanagi A., Kraemer M.U.G., Krishan K., Kugbey N., Kumar G.A., Kumar M., Kumar P., Kumar V., Kusuma D., La Vecchia C., Lacey B., Lad S.D., Lal D.K., Lam F., Lami F.H., Lamichhane P., Lansingh V.C., Lasrado S., Laxmaiah A., Lee P.H., LeGrand K.E., Leili M., Lenjebo T.L., Leshargie C.T., Levine A.J., Li S., Linn S., Liu S., Lodha R., Longbottom J., Lopez J.C.F., Magdy Abd El Razek H., Magdy Abd El Razek M., Mahadeshwara Prasad DR., Mahasha P.W., Mahotra N.B., Majeed A., Malekzadeh R., Malta D.C., Mamun A.A., Manafi N., Manda A.L., Manohar N.D.D., Mansournia M.A., Mapoma C.C., Maravilla J.C., Martinez G., Martini S., Martins-Melo F.R., Masaka A., Massenburg B.B., Mathur M.R., Mayala B.K., Mazidi M., McAlinden C., Meharie B.G., Mehndiratta M.M., Mehta K.M., Mekonnen T.C., Meles G.G., Memiah P.T.N., Memish Z.A., Mendoza W., Menezes R.G., Mereta S.T., Meretoja T.J., Mestrovic T., Miazgowski B., Mihretie K.M., Miller T.R., Mini G.K., Mirrakhimov E.M., Moazen B., Mohajer B., Mohamadi-Bolbanabad A., Mohammad D.K., Mohammad K.A., Mohammad Y., Mohammad Gholi Mezerji N., Mohammadibakhsh R., Mohammadifard N., Mohammed J.A., Mohammed S., Mohebi F., Mokdad A.H., Molokhia M., Monasta L., Moodley Y., Moore C.E., Moradi G., Moradi M., Moradi-Joo M., Moradi-Lakeh M., Moraga P., Morales L., Moreno Velasquez I., Mosapour A., Mouodi S., Mousavi S.M., Mozaffor M., Muchie K.F., Mulaw G.F., Munro S.B., Muriithi M.K., Murray C.J., Murthy G.V.S., Musa K.I., Mustafa G., Muthupandian S., Nabhan A.F., Naderi M., Nagarajan A.J., Naidoo K.S., Naik G., Najafi F., Nangia V., Nansseu J.R., Nascimento B.R., Nazari J., Ndwandwe D.E., Negoi I., Netsere H.B., Ngunjiri J.W., Nguyen C.T., Nguyen H.L.T., Nguyen T.H., Nigatu D., Nigatu S.G., Ningrum D.N.A., Nnaji C.A., Nojomi M., Nong V.M., Norheim O.F., Noubiap J.J., Nouraei Motlagh S., Oancea B., Ogah O.S., Ogbo F.A., Oh I.-H., Olagunju A.T., Olagunju T.O., Olusanya B.O., Olusanya J.O., Onwujekwe O.E., Oren E., Ortega-Altamirano D.V., Osarenotor O., Osei F.B., Owolabi M.O., P A M., Padubidri J.R., Pakhale S., Patel S.K., Paternina-Caicedo A.J., Pathak A., Patton G.C., Paudel D., Paulos K., Pepito V.C.F., Pereira A., Perico N., Pervaiz A., Pescarini J.M., Piroozi B., Pirsaheb M., Postma M.J., Pourjafar H., Pourmalek F., Pourshams A., Poustchi H., Prada S.I., Prasad N., Preotescu L., Quintana H., Rabiee N., Radfar A., Rafiei A., Rahim F., Rahimi-Movaghar A., Rahimi-Movaghar V., Rahman M.H.U., Rahman M.A., Rahman S., Rajati F., Rana S.M., Ranabhat C.L., Rasella D., Rawaf D.L., Rawaf S., Rawal L., Rawasia W.F., Renjith V., Renzaho A.M.N., Resnikoff S., Reta M.A., Rezaei N., Rezai M.S., Riahi S.M., Ribeiro A.I., Rickard J., Rios-Blancas M., Roever L., Ronfani L., Roro E.M., Ross J.M., Rubagotti E., Rubino S., Saad A.M., Sabde Y.D., Sabour S., Sadeghi E., Safari Y., Safari-Faramani R., Sagar R., Sahebkar A., Sahraian M.A., Sajadi S.M., Salahshoor M.R., Salam N., Salamati P., Salem H., Salem M.R., Salimi Y., Salimzadeh H., Samy A.M., Sanabria J., Santric-Milicevic M.M., Sao Jose B.P., Saraswathy S.Y.I., Sarkar K., Sarker A.R., Sarrafzadegan N., Sartorius B., Sathian B., Sawhney M., Saxena S., Schwebel D.C., Senbeta A.M., Senthilkumaran S., Sepanlou S.G., Servan-Mori E., Shabaninejad H., Shafieesabet A., Shaikh M.A., Shalash A.S., Shallo S.A., Shams-Beyranvand M., Shamsi M.B., Shamsizadeh M., Shannawaz M., Sharafi K., Sharifi H., Shehata H.S., Sheikh A., Shetty B.S.K., Shibuya K., Shiferaw W.S., Shifti D.M., Shigematsu M., Shin J.I., Shiri R., Shirkoohi R., Siabani S., Siddiqi T.J., Silva D.A.S., Singh J.A., Singh N.P., Singh V., Sisay M.M., Skiadaresi E., Sobhiyeh M.R., Sokhan A., Soltani S., Somayaji R., Soofi M., Sorrie M.B., Soyiri I.N., Sreeramareddy C.T., Sudaryanto A., Sufiyan M.B., Suleria H.A.R., Sultana M., Sunguya B.F., Sykes B.L., Tabares-Seisdedos R., Tabuchi T., Tadesse D.B., Tarigan I.U., Tasew A.A., Tefera Y.M., Tekle M.G., and Temsah M.

Abstract

Background: Oral rehydration solution (ORS) is a form of oral rehydration therapy (ORT) for diarrhoea that has the potential to drastically reduce child mortality; yet, according to UNICEF estimates, less than half of children younger than 5 years with diarrhoea in low-income and middle-income countries (LMICs) received ORS in 2016. A variety of recommended home fluids (RHF) exist as alternative forms of ORT; however, it is unclear whether RHF prevent child mortality. Previous studies have shown considerable variation between countries in ORS and RHF use, but subnational variation is unknown. This study aims to produce high-resolution geospatial estimates of relative and absolute coverage of ORS, RHF, and ORT (use of either ORS or RHF) in LMICs. Method(s): We used a Bayesian geostatistical model including 15 spatial covariates and data from 385 household surveys across 94 LMICs to estimate annual proportions of children younger than 5 years of age with diarrhoea who received ORS or RHF (or both) on continuous continent-wide surfaces in 2000-17, and aggregated results to policy-relevant administrative units. Additionally, we analysed geographical inequality in coverage across administrative units and estimated the number of diarrhoeal deaths averted by increased coverage over the study period. Uncertainty in the mean coverage estimates was calculated by taking 250 draws from the posterior joint distribution of the model and creating uncertainty intervals (UIs) with the 2.5th and 97.5th percentiles of those 250 draws. Finding(s): While ORS use among children with diarrhoea increased in some countries from 2000 to 2017, coverage remained below 50% in the majority (62.6%; 12 417 of 19 823) of second administrative-level units and an estimated 6 519 000 children (95% UI 5 254 000-7 733 000) with diarrhoea were not treated with any form of ORT in 2017. Increases in ORS use corresponded with declines in RHF in many locations, resulting in relatively constant overall ORT co

Published
2020

24. Mapping geographical inequalities in access to drinking water and sanitation facilities in low-income and middle-income countries, 2000–17

Author

Deshpande, A. (Aniruddha), Miller-Petrie, M. K. (Molly K.), Lindstedt, P. A. (Paulina A.), Baumann, M. M. (Mathew M.), Johnson, K. B. (Kimberly B.), Blacker, B. F. (Brigette F.), Abbastabar, H. (Hedayat), Abd-Allah, F. (Foad), Abdelalim, A. (Ahmed), Abdollahpour, I. (Ibrahim), Abegaz, K. H. (Kedir Hussein), Abejie, A. N. (Ayenew Negesse), Abreu, L. G. (Lucas Guimaraes), Abrigo, M. R. (Michael R. M.), Abualhasan, A. (Ahmed), Accrombessi, M. M. (Manfred Mario Kokou), Adamu, A. A. (Abdu A.), Adebayo, O. M. (Oladimeji M.), Adedeji, I. A. (Isaac Akinkunmi), Adedoyin, R. A. (Rufus Adesoji), Adekanmbi, V. (Victor), Adetokunboh, O. O. (Olatunji O.), Adhikari, T. B. (Tara Ballav), Afarideh, M. (Mohsen), Agudelo-Botero, M. (Marcela), Ahmadi, M. (Mehdi), Ahmadi, K. (Keivan), Ahmed, M. B. (Muktar Beshir), Ahmed, A. E. (Anwar E.), Akalu, T. Y. (Temesgen Yihunie), Akanda, A. S. (Ali S.), Alahdab, F. (Fares), Al-Aly, Z. (Ziyad), Alam, S. (Samiah), Alam, N. (Noore), Alamene, G. M. (Genet Melak), Alanzi, T. M. (Turki M.), Albright, J. (James), Albujeer, A. (Ammar), Alcalde-Rabanal, J. E. (Jacqueline Elizabeth), Alebel, A. (Animut), Alemu, Z. A. (Zewdie Aderaw), Ali, M. (Muhammad), Alijanzadeh, M. (Mehran), Alipour, V. (Vahid), Aljunid, S. M. (Syed Mohamed), Almasi, A. (Ali), Almasi-Hashiani, A. (Amir), Al-Mekhlafi, H. M. (Hesham M.), Altirkawi, K. A. (Khalid A.), Alvis-Guzman, N. (Nelson), Alvis-Zakzuk, N. J. (Nelson J.), Amini, S. (Saeed), Amit, A. M. (Arianna Maever L.), Amul, G. G. (Gianna Gayle Herrera), Andrei, C. L. (Catalina Liliana), Anjomshoa, M. (Mina), Ansariadi, A. (Ansariadi), Antonio, C. A. (Carl Abelardo T.), Antony, B. (Benny), Antriyandarti, E. (Ernoiz), Arabloo, J. (Jalal), Aref, H. M. (Hany Mohamed Amin), Aremu, O. (Olatunde), Armoon, B. (Bahram), Arora, A. (Amit), Aryal, K. K. (Krishna K.), Arzani, A. (Afsaneh), Asadi-Aliabadi, M. (Mehran), Asmelash, D. (Daniel), Atalay, H. T. (Hagos Tasew), Athari, S. M. (Seyyede Masoume), Athari, S. S. (Seyyed Shamsadin), Atre, S. R. (Sachin R.), Ausloos, M. (Marcel), Awasthi, S. (Shally), Awoke, N. (Nefsu), Quintanilla, B. P. (Beatriz Paulina Ayala), Ayano, G. (Getinet), Ayanore, M. A. (Martin Amogre), Aynalem, Y. A. (Yared Asmare), Azari, S. (Samad), Azman, A. S. (Andrew S.), Babaee, E. (Ebrahim), Badawi, A. (Alaa), Bagherzadeh, M. (Mojtaba), Bakkannavar, S. M. (Shankar M.), Balakrishnan, S. (Senthilkumar), Banach, M. (Maciej), Banoub, J. A. (Joseph Adel Mattar), Barac, A. (Aleksandra), Barboza, M. A. (Miguel A.), Barnighausen, T. W. (Till Winfried), Basu, S. (Sanjay), . (), Bayati, M. (Mohsen), Bedi, N. (Neeraj), Beheshti, M. (Mahya), Behzadifar, M. (Meysam), Behzadifar, M. (Masoud), Ramirez, D. F. (Diana Fernanda Bejarano), Bell, M. L. (Michelle L.), Bennett, D. A. (Derrick A.), Benzian, H. (Habib), Berbada, D. A. (Dessalegn Ajema), Bernstein, R. S. (Robert S.), Bhat, A. G. (Anusha Ganapati), Bhattacharyya, K. (Krittika), Bhaumik, S. (Soumyadeep), Bhutta, Z. A. (Zulfiqar A.), Bijani, A. (Ali), Bikbov, B. (Boris), Bin Sayeed, M. S. (Muhammad Shahdaat), Biswas, R. K. (Raaj Kishore), Bohlouli, S. (Somayeh), Boufous, S. (Soufiane), Brady, O. J. (Oliver J.), Briko, A. N. (Andrey Nikolaevich), Briko, N. I. (Nikolay Ivanovich), Britton, G. B. (Gabrielle B.), Brown, A. (Alexandria), Nagaraja, S. B. (Sharath Burugina), Butt, Z. A. (Zahid A.), Camera, L. A. (Luis Alberto), Campos-Nonato, I. R. (Ismael R.), Rincon, J. C. (Julio Cesar Campuzano), Cano, J. (Jorge), Car, J. (Josip), Cardenas, R. (Rosario), Carvalho, F. (Felix), Castaneda-Orjuela, C. A. (Carlos A.), Castro, F. (Franz), Cerin, E. (Ester), Chalise, B. (Binaya), Chattu, V. K. (Vijay Kumar), Chin, K. L. (Ken Lee), Christopher, D. J. (Devasahayam J.), Chu, D.-T. (Dinh-Toi), Cormier, N. M. (Natalie Maria), Costa, V. M. (Vera Marisa), Cromwell, E. A. (Elizabeth A.), Dadi, A. F. (Abel Fekadu Fekadu), Dahiru, T. (Tukur), Dahlawi, S. M. (Saad M. A.), Dandona, R. (Rakhi), Dandona, L. (Lalit), Dang, A. K. (Anh Kim), Daoud, F. (Farah), Darwesh, A. M. (Aso Mohammad), Darwish, A. H. (Amira Hamed), Daryani, A. (Ahmad), Das, J. K. (Jai K.), Das Gupta, R. (Rajat), Dash, A. P. (Aditya Prasad), Davila-Cervantes, C. A. (Claudio Alberto), Weaver, N. D. (Nicole Davis), De la Hoz, F. P. (Fernando Pio), De Neve, J.-W. (Jan-Walter), Demissie, D. B. (Dereje Bayissa), Demoz, G. T. (Gebre Teklemariam), Denova-Gutierrez, E. (Edgar), Deribe, K. (Kebede), Desalew, A. (Assefa), Dharmaratne, S. D. (Samath Dhamminda), Dhillon, P. (Preeti), Dhimal, M. (Meghnath), Dhungana, G. P. (Govinda Prasad), Diaz, D. (Daniel), Dipeolu, I. O. (Isaac Oluwafemi), Dolecek, C. (Christiane), Doyle, K. E. (Kerrie E.), Dubljanin, E. (Eleonora), Duraes, A. R. (Andre Rodrigues), Edinur, H. A. (Hisham Atan), Effiong, A. (Andem), Eftekhari, A. (Aziz), El Nahas, N. (Nevine), Zaki, M. E. (Maysaa El Sayed), El Tantawi, M. (Maha), Elhabashy, H. R. (Hala Rashad), El-Jaafary, S. I. (Shaimaa, I), El-Khatib, Z. (Ziad), Elkout, H. (Hajer), Elsharkawy, A. (Aisha), Enany, S. (Shymaa), Endalew, D. A. (Daniel Adane), Eshrati, B. (Babak), Eskandarieh, S. (Sharareh), Etemadi, A. (Arash), Ezekannagha, O. (Oluchi), Faraon, E. J. (Emerito Jose A.), Fareed, M. (Mohammad), Faro, A. (Andre), Farzadfar, F. (Farshad), Fasil, A. F. (Alebachew Fasil), Fazlzadeh, M. (Mehdi), Feigin, V. L. (Valery L.), Fekadu, W. (Wubalem), Fentahun, N. (Netsanet), Fereshtehnejad, S.-M. (Seyed-Mohammad), Fernandes, E. (Eduarda), Filip, I. (Irina), Fischer, F. (Florian), Flohr, C. (Carsten), Foigt, N. A. (Nataliya A.), Folayan, M. O. (Morenike Oluwatoyin), Foroutan, M. (Masoud), Franklin, R. C. (Richard Charles), Frostad, J. J. (Joseph Jon), Fukumoto, T. (Takeshi), Gad, M. M. (Mohamed M.), Garcia, G. M. (Gregory M.), Gatotoh, A. M. (Augustine Mwangi), Gayesa, R. T. (Reta Tsegaye), Gebremedhin, K. B. (Ketema Bizuwork), Geramo, Y. C. (Yilma Chisha Dea), Gesesew, H. A. (Hailay Abrha), Gezae, K. E. (Kebede Embaye), Ghashghaee, A. (Ahmad), Sherbaf, F. G. (Farzaneh Ghazi), Gill, T. K. (Tiffany K.), Gill, P. S. (Paramjit Singh), Ginindza, T. G. (Themba G.), Girmay, A. (Alem), Gizaw, Z. (Zemichael), Goodridge, A. (Amador), Gopalani, S. V. (Sameer Vali), Goulart, B. N. (Barbara Niegia Garcia), Goulart, A. C. (Alessandra C.), Grada, A. (Ayman), Green, M. S. (Manfred S.), Gubari, M. I. (Mohammed Ibrahim Mohialdeen), Gugnani, H. C. (Harish Chander), Guido, D. (Davide), Guimaraes, R. A. (Rafael Alves), Guo, Y. (Yuming), Gupta, R. (Rajeev), Gupta, R. (Rahul), Ha, G. H. (Giang Hai), Haagsma, J. A. (Juanita A.), Hafezi-Nejad, N. (Nima), Haile, D. H. (Dessalegn H.), Haile, M. T. (Michael Tamene), Hall, B. J. (Brian J.), Hamidi, S. (Samer), Handiso, D. W. (Demelash Woldeyohannes), Haririan, H. (Hamidreza), Hariyani, N. (Ninuk), Hasaballah, A. I. (Ahmed, I), Hasan, M. (Mehedi), Hasanzadeh, A. (Amir), Hassen, H. Y. (Hamid Yimam), Hayelom, D. H. (Desta Haftu), Hegazy, M. I. (Mohamed, I), Heibati, B. (Behzad), Heidari, B. (Behnam), Hendrie, D. (Delia), Henok, A. (Andualem), Herteliu, C. (Claudiu), Heydarpour, F. (Fatemeh), de Hidru, H. D. (Hagos Degefa), Hird, T. R. (Thomas R.), Hollerich, G. I. (Gillian, I), Hoogar, P. (Praveen), Hossain, N. (Naznin), Hosseinzadeh, M. (Mehdi), Househ, M. (Mowafa), Hu, G. (Guoqing), Humayun, A. (Ayesha), Hussain, S. A. (Syed Ather), Hussen, M. A. (Mamusha Aman A.), Ibitoye, S. E. (Segun Emmanuel), Ilesanmi, O. S. (Olayinka Stephen), Ilic, M. D. (Milena D.), Imani-Nasab, M. H. (Mohammad Hasan), Iqbal, U. (Usman), Irvani, S. S. (Seyed Sina Naghibi), Islam, S. M. (Sheikh Mohammed Shariful), Ivers, R. Q. (Rebecca Q.), Iwu, C. J. (Chinwe Juliana), Jahanmehr, N. (Nader), Jakovljevic, M. (Mihajlo), Jalali, A. (Amir), Jayatilleke, A. U. (Achala Upendra), Jenabi, E. (Ensiyeh), Jha, R. P. (Ravi Prakash), Jha, V. (Vivekanand), Ji, J. S. (John S.), Jonas, J. B. (Jost B.), Jozwiak, J. J. (Jacek Jerzy), Kabir, A. (Ali), Kabir, Z. (Zubair), Kanchan, T. (Tanuj), Karch, A. (Andre), Karki, S. (Surendra), Kasaeian, A. (Amir), Kasahun, G. G. (Gebremicheal Gebreslassie), Kasaye, H. K. (Habtamu Kebebe), Kassa, G. G. (Gebrehiwot G.), Kassa, G. M. (Getachew Mullu), Kayode, G. A. (Gbenga A.), Kebede, M. M. (Mihiretu M.), Keiyoro, P. N. (Peter Njenga), Ketema, D. B. (Daniel Bekele), Khader, Y. S. (Yousef Saleh), Khafaie, M. A. (Morteza Abdullatif), Khalid, N. (Nauman), Khalilov, R. (Rovshan), Khan, E. A. (Ejaz Ahmad), Khan, J. (Junaid), Khan, N. (Nuruzzaman), Khatab, K. (Khaled), Khater, M. M. (Mona M.), Khater, A. M. (Amir M.), Khayamzadeh, M. (Maryam), Khazaei, M. (Mohammad), Khosravi, M. H. (Mohammad Hossein), Khubchandani, J. (Jagdish), Kiadaliri, A. (Ali), Kim, Y. J. (Yun Jin), Kimokoti, R. W. (Ruth W.), Kisa, S. (Sezer), Kisa, A. (Adnan), Kochhar, S. (Sonali), Kolola, T. (Tufa), Komaki, H. (Hamidreza), Kosen, S. (Soewarta), Koul, P. A. (Parvaiz A.), Koyanagi, A. (Ai), Krishan, K. (Kewal), Defo, B. K. (Barthelemy Kuate), Kugbey, N. (Nuworza), Kumar, P. (Pushpendra), Kumar, G. A. (G. Anil), Kumar, M. (Manasi), Kusuma, D. (Dian), La Vecchia, C. (Carlo), Lacey, B. (Ben), Lal, A. (Aparna), Lal, D. K. (Dharmesh Kumar), Lam, H. (Hilton), Lami, F. H. (Faris Hasan), Lansingh, V. C. (Van Charles), Lasrado, S. (Savita), Lebedev, G. (Georgy), Lee, P. H. (Paul H.), LeGrand, K. E. (Kate E.), Leili, M. (Mostafa), Lenjebo, T. L. (Tsegaye Lolaso), Leshargie, C. T. (Cheru Tesema), Levine, A. J. (Aubrey J.), Lewycka, S. (Sonia), Li, S. (Shanshan), Linn, S. (Shai), Liu, S. (Shiwei), Lopez, J. C. (Jaifred Christian F.), Lopukhov, P. D. (Platon D.), Abd El Razek, M. M. (Muhammed Magdy), Prasad, D. R. (D. R. Mahadeshwara), Mahasha, P. W. (Phetole Walter), Mahotra, N. B. (Narayan B.), Majeed, A. (Azeem), Malekzadeh, R. (Reza), Malta, D. C. (Deborah Carvalho), Mamun, A. A. (Abdullah A.), Manafi, N. (Navid), Mansournia, M. A. (Mohammad Ali), Mapoma, C. C. (Chabila Christopher), Martinez, G. (Gabriel), Martini, S. (Santi), Martins-Melo, F. R. (Francisco Rogerlandio), Mathur, M. R. (Manu Raj), Mayala, B. K. (Benjamin K.), Mazidi, M. (Mohsen), McAlinden, C. (Colm), Meharie, B. G. (Birhanu Geta), Mehndiratta, M. M. (Man Mohan), Nasab, E. M. (Entezar Mehrabi), Mehta, K. M. (Kala M.), Mekonnen, T. (Teferi), Mekonnen, T. C. (Tefera Chane), Meles, G. G. (Gebrekiros Gebremichael), Meles, H. G. (Hagazi Gebre), Memiah, P. T. (Peter T. N.), Memish, Z. A. (Ziad A.), Mendoza, W. (Walter), Menezes, R. G. (Ritesh G.), Mereta, S. T. (Seid Tiku), Meretoja, T. J. (Tuomo J.), Mestrovic, T. (Tomislav), Metekiya, W. M. (Workua Mekonnen), Miazgowski, B. (Bartosz), Miller, T. R. (Ted R.), Mini, G. K. (G. K.), Mirrakhimov, E. M. (Erkin M.), Moazen, B. (Babak), Mohajer, B. (Bahram), Mohammad, Y. (Yousef), Mohammad, D. K. (Dara K.), Mezerji, N. M. (Naser Mohammad Gholi), Mohammadibakhsh, R. (Roghayeh), Mohammed, S. (Shafiu), Mohammed, J. A. (Jemal Abdu), Mohammed, H. (Hassen), Mohebi, F. (Farnam), Mokdad, A. H. (Ali H.), Moodley, Y. (Yoshan), Moradi, M. (Masoud), Moradi, G. (Ghobad), Moradi-Joo, M. (Mohammad), Moraga, P. (Paula), Morales, L. (Linda), Mosapour, A. (Abbas), Mosser, J. F. (Jonathan F.), Mouodi, S. (Simin), Mousavi, S. M. (Seyyed Meysam), Mozaffor, M. (Miliva), Munro, S. B. (Sandra B.), Muriithi, M. K. (Moses K.), Murray, C. J. (Christopher J. L.), Musa, K. I. (Kamarul Imran), Mustafa, G. (Ghulam), Muthupandian, S. (Saravanan), Naderi, M. (Mehdi), Nagarajan, A. J. (Ahamarshan Jayaraman), Naghavi, M. (Mohsen), Naik, G. (Gurudatta), Nangia, V. (Vinay), Nascimento, B. R. (Bruno Ramos), Nazari, J. (Javad), Ndwandwe, D. E. (Duduzile Edith), Negoi, I. (Ionut), Netsere, H. B. (Henok Biresaw), Ngunjiri, J. W. (Josephine W.), Nguyen, Q. P. (QuynhAnh P.), Nigatu, S. G. (Solomon Gedlu), Ningrum, D. N. (Dina Nur Anggraini), Nnaji, C. A. (Chukwudi A.), Nojomi, M. (Marzieh), Norheim, O. F. (Ole F.), Noubiap, J. J. (Jean Jacques), Oancea, B. (Bogdan), Ogbo, F. A. (Felix Akpojene), Oh, I.-H. (In-Hwan), Olagunju, A. T. (Andrew T.), Olusanya, J. O. (Jacob Olusegun), Olusanya, B. O. (Bolajoko Olubukunola), Onwujekwe, O. E. (Obinna E.), Ortega-Altamirano, D. V. (Doris, V), Osarenotor, O. (Osayomwanbo), Osei, F. B. (Frank B.), Owolabi, M. O. (Mayowa O.), Mahesh, P. A. (P. A.), Padubidri, J. R. (Jagadish Rao), Pakhale, S. (Smita), Pana, A. (Adrian), Park, E.-K. (Eun-Kee), Patel, S. K. (Sangram Kishor), Pathak, A. (Ashish), Patle, A. (Ajay), Paulos, K. (Kebreab), Pepito, V. C. (Veincent Christian Filipino), Perico, N. (Norberto), Pervaiz, A. (Aslam), Pescarini, J. M. (Julia Moreira), Pesudovs, K. (Konrad), Pham, H. Q. (Hai Quang), Pigott, D. M. (David M.), Pilgrim, T. (Thomas), Pirsaheb, M. (Meghdad), Poljak, M. (Mario), Pollock, I. (Ian), Postma, M. J. (Maarten J.), Pourmalek, F. (Farshad), Pourshams, A. (Akram), Prada, S. I. (Sergio, I), Preotescu, L. (Liliana), Quintana, H. (Hedley), Rabiee, N. (Navid), Rabiee, M. (Mohammad), Radfar, A. (Amir), Rafiei, A. (Alireza), Rahim, F. (Fakher), Rahimi, S. (Siavash), Rahimi-Movaghar, V. (Vafa), Rahman, M. A. (Muhammad Aziz), Rahman, M. H. (Mohammad Hifz Ur), Rajati, F. (Fatemeh), Ranabhat, C. L. (Chhabi Lal), Rao, P. C. (Puja C.), Rasella, D. (Davide), Rath, G. K. (Goura Kishor), Rawaf, S. (Salman), Rawal, L. (Lal), Rawasia, W. F. (Wasiq Faraz), Remuzzi, G. (Giuseppe), Renjith, V. (Vishnu), Renzaho, A. M. (Andre M. N.), Resnikoff, S. (Serge), Riahi, S. M. (Seyed Mohammad), Ribeiro, A. I. (Ana Isabel), Rickard, J. (Jennifer), Roever, L. (Leonardo), Ronfani, L. (Luca), Rubagotti, E. (Enrico), Rubino, S. (Salvatore), Saad, A. M. (Anas M.), Sabour, S. (Siamak), Sadeghi, E. (Ehsan), Moghaddam, S. S. (Sahar Saeedi), Safari, Y. (Yahya), Sagar, R. (Rajesh), Sahraian, M. A. (Mohammad Ali), Sajadi, S. M. (S. Mohammad), Salahshoor, M. R. (Mohammad Reza), Salam, N. (Nasir), Saleem, A. (Ahsan), Salem, H. (Hosni), Salem, M. R. (Marwa Rashad), Salimi, Y. (Yahya), Salimzadeh, H. (Hamideh), Samy, A. M. (Abdallah M.), Sanabria, J. (Juan), Santos, I. S. (Itamar S.), Santric-Milicevic, M. M. (Milena M.), Sao Jose, B. P. (Bruno Piassi), Saraswathy, S. Y. (Sivan Yegnanarayana Iyer), Sarrafzadegan, N. (Nizal), Sartorius, B. (Benn), Sathian, B. (Brijesh), Sathish, T. (Thirunavukkarasu), Satpathy, M. (Maheswar), Sawhney, M. (Monika), Sayyah, M. (Mehdi), Sbarra, A. N. (Alyssa N.), Schaeffer, L. E. (Lauren E.), Schwebel, D. C. (David C.), Senbeta, A. M. (Anbissa Muleta), Senthilkumaran, S. (Subramanian), Sepanlou, S. G. (Sadaf G.), Servan-Mori, E. (Edson), Shafieesabet, A. (Azadeh), Shaheen, A. A. (Amira A.), Shahid, I. (Izza), Shaikh, M. A. (Masood Ali), Shalash, A. S. (Ali S.), Shams-Beyranvand, M. (Mehran), Shamsi, M. (MohammadBagher), Shamsizadeh, M. (Morteza), Shannawaz, M. (Mohammed), Sharafi, K. (Kiomars), Sharma, R. (Rajesh), Sheikh, A. (Aziz), Shetty, B. S. (B. Suresh Kumar), Shiferaw, W. S. (Wondimeneh Shibabaw), Shigematsu, M. (Mika), Shin, J. I. (Jae Il), Shiri, R. (Rahman), Shirkoohi, R. (Reza), Shivakumar, K. M. (K. M.), Si, S. (Si), Siabani, S. (Soraya), Siddiqi, T. J. (Tariq Jamal), Silva, D. A. (Diego Augusto Santos), Singh, V. (Virendra), Singh, N. P. (Narinder Pal), Singh, B. B. (Balbir Bagicha Singh), Singh, J. A. (Jasvinder A.), Singh, A. (Ambrish), Sinha, D. N. (Dhirendra Narain), Sisay, M. M. (Malede Mequanent), Skiadaresi, E. (Eirini), Smith, D. L. (David L.), Filho, A. M. (Adauto Martins Soares), Sobhiyeh, M. R. (Mohammad Reza), Sokhan, A. (Anton), Soriano, J. B. (Joan B.), Sorrie, M. B. (Muluken Bekele), Soyiri, I. N. (Ireneous N.), Spurlock, E. E. (Emma Elizabeth), Sreeramareddy, C. T. (Chandrashekhar T.), Sudaryanto, A. (Agus), Sufiyan, M. B. (Mu'awiyyah Babale), Suleria, H. A. (Hafiz Ansar Rasul), Sykes, B. L. (Bryan L.), Tabares-Seisdedos, R. (Rafael), Tabuchi, T. (Takahiro), Tadesse, D. B. (Degena Bahrey), Tarigan, I. U. (Ingan Ukur), Taye, B. (Bineyam), Tefera, Y. M. (Yonatal Mesfin), Tehrani-Banihashemi, A. (Arash), Tekelemedhin, S. W. (Shishay Wahdey), Tekle, M. G. (Merhawi Gebremedhin), Temsah, M.-H. (Mohamad-Hani), Tesfay, B. E. (Berhe Etsay), Tesfay, F. H. (Fisaha Haile), Tessema, Z. T. (Zemenu Tadesse), Thankappan, K. R. (Kavumpurathu Raman), ThekkePurakkal, A. S. (Akhil Soman), Thomas, N. (Nihal), Thompson, R. L. (Robert L.), Thomson, A. J. (Alan J.), Topor-Madry, R. (Roman), Tovani-Palone, M. R. (Marcos Roberto), Traini, E. (Eugenio), Ullah, I. (Irfan), Unnikrishnan, B. (Bhaskaran), Usman, M. S. (Muhammad Shariq), Uthman, O. A. (Olalekan A.), Uzochukwu, B. S. (Benjamin S. Chudi), Valdez, P. R. (Pascual R.), Varughese, S. (Santosh), Veisani, Y. (Yousef), Violante, F. S. (Francesco S.), Vollmer, S. (Sebastian), Whawariat, F. G. (Feleke Gebremeskel), Waheed, Y. (Yasir), Wallin, M. T. (Mitchell Taylor), Wang, Y.-P. (Yuan-Pang), Wang, Y. (Yafeng), Wangdi, K. (Kinley), Weiss, D. J. (Daniel J.), Weldesamuel, G. T. (Girmay Teklay), Werkneh, A. A. (Adhena Ayaliew), Westerman, R. (Ronny), Wiangkham, T. (Taweewat), Wiens, K. E. (Kirsten E.), Wijeratne, T. (Tissa), Wiysonge, C. S. (Charles Shey), Wolde, H. F. (Haileab Fekadu), Wondafrash, D. Z. (Dawit Zewdu), Wonde, T. E. (Tewodros Eshete), Worku, G. T. (Getasew Taddesse), Yadollahpour, A. (Ali), Jabbari, S. H. (Seyed Hossein Yahyazadeh), Yamada, T. (Tomohide), Yaseri, M. (Mehdi), Yatsuya, H. (Hiroshi), Yeshaneh, A. (Alex), Yilma, M. T. (Mekdes Tigistu), Yip, P. (Paul), Yisma, E. (Engida), Yonemoto, N. (Naohiro), Younis, M. Z. (Mustafa Z.), Yousof, H. S. (Hebat-Allah Salah A.), Yu, C. (Chuanhua), Yusefzadeh, H. (Hasan), Zadey, S. (Siddhesh), Moghadam, T. Z. (Telma Zahirian), Zaidi, Z. (Zoubida), Bin Zaman, S. (Sojib), Zamani, M. (Mohammad), Zandian, H. (Hamed), Zar, H. J. (Heather J.), Zerfu, T. A. (Taddese Alemu), Zhang, Y. (Yunquan), Ziapour, A. (Arash), Zodpey, S. (Sanjay), Zuniga, Y. M. (Yves Miel H.), Hay, S. I. (Simon, I), Reiner, R. C. (Robert C., Jr.), Deshpande, A. (Aniruddha), Miller-Petrie, M. K. (Molly K.), Lindstedt, P. A. (Paulina A.), Baumann, M. M. (Mathew M.), Johnson, K. B. (Kimberly B.), Blacker, B. F. (Brigette F.), Abbastabar, H. (Hedayat), Abd-Allah, F. (Foad), Abdelalim, A. (Ahmed), Abdollahpour, I. (Ibrahim), Abegaz, K. H. (Kedir Hussein), Abejie, A. N. (Ayenew Negesse), Abreu, L. G. (Lucas Guimaraes), Abrigo, M. R. (Michael R. M.), Abualhasan, A. (Ahmed), Accrombessi, M. M. (Manfred Mario Kokou), Adamu, A. A. (Abdu A.), Adebayo, O. M. (Oladimeji M.), Adedeji, I. A. (Isaac Akinkunmi), Adedoyin, R. A. (Rufus Adesoji), Adekanmbi, V. (Victor), Adetokunboh, O. O. (Olatunji O.), Adhikari, T. B. (Tara Ballav), Afarideh, M. (Mohsen), Agudelo-Botero, M. (Marcela), Ahmadi, M. (Mehdi), Ahmadi, K. (Keivan), Ahmed, M. B. (Muktar Beshir), Ahmed, A. E. (Anwar E.), Akalu, T. Y. (Temesgen Yihunie), Akanda, A. S. (Ali S.), Alahdab, F. (Fares), Al-Aly, Z. (Ziyad), Alam, S. (Samiah), Alam, N. (Noore), Alamene, G. M. (Genet Melak), Alanzi, T. M. (Turki M.), Albright, J. (James), Albujeer, A. (Ammar), Alcalde-Rabanal, J. E. (Jacqueline Elizabeth), Alebel, A. (Animut), Alemu, Z. A. (Zewdie Aderaw), Ali, M. (Muhammad), Alijanzadeh, M. (Mehran), Alipour, V. (Vahid), Aljunid, S. M. (Syed Mohamed), Almasi, A. (Ali), Almasi-Hashiani, A. (Amir), Al-Mekhlafi, H. M. (Hesham M.), Altirkawi, K. A. (Khalid A.), Alvis-Guzman, N. (Nelson), Alvis-Zakzuk, N. J. (Nelson J.), Amini, S. (Saeed), Amit, A. M. (Arianna Maever L.), Amul, G. G. (Gianna Gayle Herrera), Andrei, C. L. (Catalina Liliana), Anjomshoa, M. (Mina), Ansariadi, A. (Ansariadi), Antonio, C. A. (Carl Abelardo T.), Antony, B. (Benny), Antriyandarti, E. (Ernoiz), Arabloo, J. (Jalal), Aref, H. M. (Hany Mohamed Amin), Aremu, O. (Olatunde), Armoon, B. (Bahram), Arora, A. (Amit), Aryal, K. K. (Krishna K.), Arzani, A. (Afsaneh), Asadi-Aliabadi, M. (Mehran), Asmelash, D. (Daniel), Atalay, H. T. (Hagos Tasew), Athari, S. M. (Seyyede Masoume), Athari, S. S. (Seyyed Shamsadin), Atre, S. R. (Sachin R.), Ausloos, M. (Marcel), Awasthi, S. (Shally), Awoke, N. (Nefsu), Quintanilla, B. P. (Beatriz Paulina Ayala), Ayano, G. (Getinet), Ayanore, M. A. (Martin Amogre), Aynalem, Y. A. (Yared Asmare), Azari, S. (Samad), Azman, A. S. (Andrew S.), Babaee, E. (Ebrahim), Badawi, A. (Alaa), Bagherzadeh, M. (Mojtaba), Bakkannavar, S. M. (Shankar M.), Balakrishnan, S. (Senthilkumar), Banach, M. (Maciej), Banoub, J. A. (Joseph Adel Mattar), Barac, A. (Aleksandra), Barboza, M. A. (Miguel A.), Barnighausen, T. W. (Till Winfried), Basu, S. (Sanjay), . (), Bayati, M. (Mohsen), Bedi, N. (Neeraj), Beheshti, M. (Mahya), Behzadifar, M. (Meysam), Behzadifar, M. (Masoud), Ramirez, D. F. (Diana Fernanda Bejarano), Bell, M. L. (Michelle L.), Bennett, D. A. (Derrick A.), Benzian, H. (Habib), Berbada, D. A. (Dessalegn Ajema), Bernstein, R. S. (Robert S.), Bhat, A. G. (Anusha Ganapati), Bhattacharyya, K. (Krittika), Bhaumik, S. (Soumyadeep), Bhutta, Z. A. (Zulfiqar A.), Bijani, A. (Ali), Bikbov, B. (Boris), Bin Sayeed, M. S. (Muhammad Shahdaat), Biswas, R. K. (Raaj Kishore), Bohlouli, S. (Somayeh), Boufous, S. (Soufiane), Brady, O. J. (Oliver J.), Briko, A. N. (Andrey Nikolaevich), Briko, N. I. (Nikolay Ivanovich), Britton, G. B. (Gabrielle B.), Brown, A. (Alexandria), Nagaraja, S. B. (Sharath Burugina), Butt, Z. A. (Zahid A.), Camera, L. A. (Luis Alberto), Campos-Nonato, I. R. (Ismael R.), Rincon, J. C. (Julio Cesar Campuzano), Cano, J. (Jorge), Car, J. (Josip), Cardenas, R. (Rosario), Carvalho, F. (Felix), Castaneda-Orjuela, C. A. (Carlos A.), Castro, F. (Franz), Cerin, E. (Ester), Chalise, B. (Binaya), Chattu, V. K. (Vijay Kumar), Chin, K. L. (Ken Lee), Christopher, D. J. (Devasahayam J.), Chu, D.-T. (Dinh-Toi), Cormier, N. M. (Natalie Maria), Costa, V. M. (Vera Marisa), Cromwell, E. A. (Elizabeth A.), Dadi, A. F. (Abel Fekadu Fekadu), Dahiru, T. (Tukur), Dahlawi, S. M. (Saad M. A.), Dandona, R. (Rakhi), Dandona, L. (Lalit), Dang, A. K. (Anh Kim), Daoud, F. (Farah), Darwesh, A. M. (Aso Mohammad), Darwish, A. H. (Amira Hamed), Daryani, A. (Ahmad), Das, J. K. (Jai K.), Das Gupta, R. (Rajat), Dash, A. P. (Aditya Prasad), Davila-Cervantes, C. A. (Claudio Alberto), Weaver, N. D. (Nicole Davis), De la Hoz, F. P. (Fernando Pio), De Neve, J.-W. (Jan-Walter), Demissie, D. B. (Dereje Bayissa), Demoz, G. T. (Gebre Teklemariam), Denova-Gutierrez, E. (Edgar), Deribe, K. (Kebede), Desalew, A. (Assefa), Dharmaratne, S. D. (Samath Dhamminda), Dhillon, P. (Preeti), Dhimal, M. (Meghnath), Dhungana, G. P. (Govinda Prasad), Diaz, D. (Daniel), Dipeolu, I. O. (Isaac Oluwafemi), Dolecek, C. (Christiane), Doyle, K. E. (Kerrie E.), Dubljanin, E. (Eleonora), Duraes, A. R. (Andre Rodrigues), Edinur, H. A. (Hisham Atan), Effiong, A. (Andem), Eftekhari, A. (Aziz), El Nahas, N. (Nevine), Zaki, M. E. (Maysaa El Sayed), El Tantawi, M. (Maha), Elhabashy, H. R. (Hala Rashad), El-Jaafary, S. I. (Shaimaa, I), El-Khatib, Z. (Ziad), Elkout, H. (Hajer), Elsharkawy, A. (Aisha), Enany, S. (Shymaa), Endalew, D. A. (Daniel Adane), Eshrati, B. (Babak), Eskandarieh, S. (Sharareh), Etemadi, A. (Arash), Ezekannagha, O. (Oluchi), Faraon, E. J. (Emerito Jose A.), Fareed, M. (Mohammad), Faro, A. (Andre), Farzadfar, F. (Farshad), Fasil, A. F. (Alebachew Fasil), Fazlzadeh, M. (Mehdi), Feigin, V. L. (Valery L.), Fekadu, W. (Wubalem), Fentahun, N. (Netsanet), Fereshtehnejad, S.-M. (Seyed-Mohammad), Fernandes, E. (Eduarda), Filip, I. (Irina), Fischer, F. (Florian), Flohr, C. (Carsten), Foigt, N. A. (Nataliya A.), Folayan, M. O. (Morenike Oluwatoyin), Foroutan, M. (Masoud), Franklin, R. C. (Richard Charles), Frostad, J. J. (Joseph Jon), Fukumoto, T. (Takeshi), Gad, M. M. (Mohamed M.), Garcia, G. M. (Gregory M.), Gatotoh, A. M. (Augustine Mwangi), Gayesa, R. T. (Reta Tsegaye), Gebremedhin, K. B. (Ketema Bizuwork), Geramo, Y. C. (Yilma Chisha Dea), Gesesew, H. A. (Hailay Abrha), Gezae, K. E. (Kebede Embaye), Ghashghaee, A. (Ahmad), Sherbaf, F. G. (Farzaneh Ghazi), Gill, T. K. (Tiffany K.), Gill, P. S. (Paramjit Singh), Ginindza, T. G. (Themba G.), Girmay, A. (Alem), Gizaw, Z. (Zemichael), Goodridge, A. (Amador), Gopalani, S. V. (Sameer Vali), Goulart, B. N. (Barbara Niegia Garcia), Goulart, A. C. (Alessandra C.), Grada, A. (Ayman), Green, M. S. (Manfred S.), Gubari, M. I. (Mohammed Ibrahim Mohialdeen), Gugnani, H. C. (Harish Chander), Guido, D. (Davide), Guimaraes, R. A. (Rafael Alves), Guo, Y. (Yuming), Gupta, R. (Rajeev), Gupta, R. (Rahul), Ha, G. H. (Giang Hai), Haagsma, J. A. (Juanita A.), Hafezi-Nejad, N. (Nima), Haile, D. H. (Dessalegn H.), Haile, M. T. (Michael Tamene), Hall, B. J. (Brian J.), Hamidi, S. (Samer), Handiso, D. W. (Demelash Woldeyohannes), Haririan, H. (Hamidreza), Hariyani, N. (Ninuk), Hasaballah, A. I. (Ahmed, I), Hasan, M. (Mehedi), Hasanzadeh, A. (Amir), Hassen, H. Y. (Hamid Yimam), Hayelom, D. H. (Desta Haftu), Hegazy, M. I. (Mohamed, I), Heibati, B. (Behzad), Heidari, B. (Behnam), Hendrie, D. (Delia), Henok, A. (Andualem), Herteliu, C. (Claudiu), Heydarpour, F. (Fatemeh), de Hidru, H. D. (Hagos Degefa), Hird, T. R. (Thomas R.), Hollerich, G. I. (Gillian, I), Hoogar, P. (Praveen), Hossain, N. (Naznin), Hosseinzadeh, M. (Mehdi), Househ, M. (Mowafa), Hu, G. (Guoqing), Humayun, A. (Ayesha), Hussain, S. A. (Syed Ather), Hussen, M. A. (Mamusha Aman A.), Ibitoye, S. E. (Segun Emmanuel), Ilesanmi, O. S. (Olayinka Stephen), Ilic, M. D. (Milena D.), Imani-Nasab, M. H. (Mohammad Hasan), Iqbal, U. (Usman), Irvani, S. S. (Seyed Sina Naghibi), Islam, S. M. (Sheikh Mohammed Shariful), Ivers, R. Q. (Rebecca Q.), Iwu, C. J. (Chinwe Juliana), Jahanmehr, N. (Nader), Jakovljevic, M. (Mihajlo), Jalali, A. (Amir), Jayatilleke, A. U. (Achala Upendra), Jenabi, E. (Ensiyeh), Jha, R. P. (Ravi Prakash), Jha, V. (Vivekanand), Ji, J. S. (John S.), Jonas, J. B. (Jost B.), Jozwiak, J. J. (Jacek Jerzy), Kabir, A. (Ali), Kabir, Z. (Zubair), Kanchan, T. (Tanuj), Karch, A. (Andre), Karki, S. (Surendra), Kasaeian, A. (Amir), Kasahun, G. G. (Gebremicheal Gebreslassie), Kasaye, H. K. (Habtamu Kebebe), Kassa, G. G. (Gebrehiwot G.), Kassa, G. M. (Getachew Mullu), Kayode, G. A. (Gbenga A.), Kebede, M. M. (Mihiretu M.), Keiyoro, P. N. (Peter Njenga), Ketema, D. B. (Daniel Bekele), Khader, Y. S. (Yousef Saleh), Khafaie, M. A. (Morteza Abdullatif), Khalid, N. (Nauman), Khalilov, R. (Rovshan), Khan, E. A. (Ejaz Ahmad), Khan, J. (Junaid), Khan, N. (Nuruzzaman), Khatab, K. (Khaled), Khater, M. M. (Mona M.), Khater, A. M. (Amir M.), Khayamzadeh, M. (Maryam), Khazaei, M. (Mohammad), Khosravi, M. H. (Mohammad Hossein), Khubchandani, J. (Jagdish), Kiadaliri, A. (Ali), Kim, Y. J. (Yun Jin), Kimokoti, R. W. (Ruth W.), Kisa, S. (Sezer), Kisa, A. (Adnan), Kochhar, S. (Sonali), Kolola, T. (Tufa), Komaki, H. (Hamidreza), Kosen, S. (Soewarta), Koul, P. A. (Parvaiz A.), Koyanagi, A. (Ai), Krishan, K. (Kewal), Defo, B. K. (Barthelemy Kuate), Kugbey, N. (Nuworza), Kumar, P. (Pushpendra), Kumar, G. A. (G. Anil), Kumar, M. (Manasi), Kusuma, D. (Dian), La Vecchia, C. (Carlo), Lacey, B. (Ben), Lal, A. (Aparna), Lal, D. K. (Dharmesh Kumar), Lam, H. (Hilton), Lami, F. H. (Faris Hasan), Lansingh, V. C. (Van Charles), Lasrado, S. (Savita), Lebedev, G. (Georgy), Lee, P. H. (Paul H.), LeGrand, K. E. (Kate E.), Leili, M. (Mostafa), Lenjebo, T. L. (Tsegaye Lolaso), Leshargie, C. T. (Cheru Tesema), Levine, A. J. (Aubrey J.), Lewycka, S. (Sonia), Li, S. (Shanshan), Linn, S. (Shai), Liu, S. (Shiwei), Lopez, J. C. (Jaifred Christian F.), Lopukhov, P. D. (Platon D.), Abd El Razek, M. M. (Muhammed Magdy), Prasad, D. R. (D. R. Mahadeshwara), Mahasha, P. W. (Phetole Walter), Mahotra, N. B. (Narayan B.), Majeed, A. (Azeem), Malekzadeh, R. (Reza), Malta, D. C. (Deborah Carvalho), Mamun, A. A. (Abdullah A.), Manafi, N. (Navid), Mansournia, M. A. (Mohammad Ali), Mapoma, C. C. (Chabila Christopher), Martinez, G. (Gabriel), Martini, S. (Santi), Martins-Melo, F. R. (Francisco Rogerlandio), Mathur, M. R. (Manu Raj), Mayala, B. K. (Benjamin K.), Mazidi, M. (Mohsen), McAlinden, C. (Colm), Meharie, B. G. (Birhanu Geta), Mehndiratta, M. M. (Man Mohan), Nasab, E. M. (Entezar Mehrabi), Mehta, K. M. (Kala M.), Mekonnen, T. (Teferi), Mekonnen, T. C. (Tefera Chane), Meles, G. G. (Gebrekiros Gebremichael), Meles, H. G. (Hagazi Gebre), Memiah, P. T. (Peter T. N.), Memish, Z. A. (Ziad A.), Mendoza, W. (Walter), Menezes, R. G. (Ritesh G.), Mereta, S. T. (Seid Tiku), Meretoja, T. J. (Tuomo J.), Mestrovic, T. (Tomislav), Metekiya, W. M. (Workua Mekonnen), Miazgowski, B. (Bartosz), Miller, T. R. (Ted R.), Mini, G. K. (G. K.), Mirrakhimov, E. M. (Erkin M.), Moazen, B. (Babak), Mohajer, B. (Bahram), Mohammad, Y. (Yousef), Mohammad, D. K. (Dara K.), Mezerji, N. M. (Naser Mohammad Gholi), Mohammadibakhsh, R. (Roghayeh), Mohammed, S. (Shafiu), Mohammed, J. A. (Jemal Abdu), Mohammed, H. (Hassen), Mohebi, F. (Farnam), Mokdad, A. H. (Ali H.), Moodley, Y. (Yoshan), Moradi, M. (Masoud), Moradi, G. (Ghobad), Moradi-Joo, M. (Mohammad), Moraga, P. (Paula), Morales, L. (Linda), Mosapour, A. (Abbas), Mosser, J. F. (Jonathan F.), Mouodi, S. (Simin), Mousavi, S. M. (Seyyed Meysam), Mozaffor, M. (Miliva), Munro, S. B. (Sandra B.), Muriithi, M. K. (Moses K.), Murray, C. J. (Christopher J. L.), Musa, K. I. (Kamarul Imran), Mustafa, G. (Ghulam), Muthupandian, S. (Saravanan), Naderi, M. (Mehdi), Nagarajan, A. J. (Ahamarshan Jayaraman), Naghavi, M. (Mohsen), Naik, G. (Gurudatta), Nangia, V. (Vinay), Nascimento, B. R. (Bruno Ramos), Nazari, J. (Javad), Ndwandwe, D. E. (Duduzile Edith), Negoi, I. (Ionut), Netsere, H. B. (Henok Biresaw), Ngunjiri, J. W. (Josephine W.), Nguyen, Q. P. (QuynhAnh P.), Nigatu, S. G. (Solomon Gedlu), Ningrum, D. N. (Dina Nur Anggraini), Nnaji, C. A. (Chukwudi A.), Nojomi, M. (Marzieh), Norheim, O. F. (Ole F.), Noubiap, J. J. (Jean Jacques), Oancea, B. (Bogdan), Ogbo, F. A. (Felix Akpojene), Oh, I.-H. (In-Hwan), Olagunju, A. T. (Andrew T.), Olusanya, J. O. (Jacob Olusegun), Olusanya, B. O. (Bolajoko Olubukunola), Onwujekwe, O. E. (Obinna E.), Ortega-Altamirano, D. V. (Doris, V), Osarenotor, O. (Osayomwanbo), Osei, F. B. (Frank B.), Owolabi, M. O. (Mayowa O.), Mahesh, P. A. (P. A.), Padubidri, J. R. (Jagadish Rao), Pakhale, S. (Smita), Pana, A. (Adrian), Park, E.-K. (Eun-Kee), Patel, S. K. (Sangram Kishor), Pathak, A. (Ashish), Patle, A. (Ajay), Paulos, K. (Kebreab), Pepito, V. C. (Veincent Christian Filipino), Perico, N. (Norberto), Pervaiz, A. (Aslam), Pescarini, J. M. (Julia Moreira), Pesudovs, K. (Konrad), Pham, H. Q. (Hai Quang), Pigott, D. M. (David M.), Pilgrim, T. (Thomas), Pirsaheb, M. (Meghdad), Poljak, M. (Mario), Pollock, I. (Ian), Postma, M. J. (Maarten J.), Pourmalek, F. (Farshad), Pourshams, A. (Akram), Prada, S. I. (Sergio, I), Preotescu, L. (Liliana), Quintana, H. (Hedley), Rabiee, N. (Navid), Rabiee, M. (Mohammad), Radfar, A. (Amir), Rafiei, A. (Alireza), Rahim, F. (Fakher), Rahimi, S. (Siavash), Rahimi-Movaghar, V. (Vafa), Rahman, M. A. (Muhammad Aziz), Rahman, M. H. (Mohammad Hifz Ur), Rajati, F. (Fatemeh), Ranabhat, C. L. (Chhabi Lal), Rao, P. C. (Puja C.), Rasella, D. (Davide), Rath, G. K. (Goura Kishor), Rawaf, S. (Salman), Rawal, L. (Lal), Rawasia, W. F. (Wasiq Faraz), Remuzzi, G. (Giuseppe), Renjith, V. (Vishnu), Renzaho, A. M. (Andre M. N.), Resnikoff, S. (Serge), Riahi, S. M. (Seyed Mohammad), Ribeiro, A. I. (Ana Isabel), Rickard, J. (Jennifer), Roever, L. (Leonardo), Ronfani, L. (Luca), Rubagotti, E. (Enrico), Rubino, S. (Salvatore), Saad, A. M. (Anas M.), Sabour, S. (Siamak), Sadeghi, E. (Ehsan), Moghaddam, S. S. (Sahar Saeedi), Safari, Y. (Yahya), Sagar, R. (Rajesh), Sahraian, M. A. (Mohammad Ali), Sajadi, S. M. (S. Mohammad), Salahshoor, M. R. (Mohammad Reza), Salam, N. (Nasir), Saleem, A. (Ahsan), Salem, H. (Hosni), Salem, M. R. (Marwa Rashad), Salimi, Y. (Yahya), Salimzadeh, H. (Hamideh), Samy, A. M. (Abdallah M.), Sanabria, J. (Juan), Santos, I. S. (Itamar S.), Santric-Milicevic, M. M. (Milena M.), Sao Jose, B. P. (Bruno Piassi), Saraswathy, S. Y. (Sivan Yegnanarayana Iyer), Sarrafzadegan, N. (Nizal), Sartorius, B. (Benn), Sathian, B. (Brijesh), Sathish, T. (Thirunavukkarasu), Satpathy, M. (Maheswar), Sawhney, M. (Monika), Sayyah, M. (Mehdi), Sbarra, A. N. (Alyssa N.), Schaeffer, L. E. (Lauren E.), Schwebel, D. C. (David C.), Senbeta, A. M. (Anbissa Muleta), Senthilkumaran, S. (Subramanian), Sepanlou, S. G. (Sadaf G.), Servan-Mori, E. (Edson), Shafieesabet, A. (Azadeh), Shaheen, A. A. (Amira A.), Shahid, I. (Izza), Shaikh, M. A. (Masood Ali), Shalash, A. S. (Ali S.), Shams-Beyranvand, M. (Mehran), Shamsi, M. (MohammadBagher), Shamsizadeh, M. (Morteza), Shannawaz, M. (Mohammed), Sharafi, K. (Kiomars), Sharma, R. (Rajesh), Sheikh, A. (Aziz), Shetty, B. S. (B. Suresh Kumar), Shiferaw, W. S. (Wondimeneh Shibabaw), Shigematsu, M. (Mika), Shin, J. I. (Jae Il), Shiri, R. (Rahman), Shirkoohi, R. (Reza), Shivakumar, K. M. (K. M.), Si, S. (Si), Siabani, S. (Soraya), Siddiqi, T. J. (Tariq Jamal), Silva, D. A. (Diego Augusto Santos), Singh, V. (Virendra), Singh, N. P. (Narinder Pal), Singh, B. B. (Balbir Bagicha Singh), Singh, J. A. (Jasvinder A.), Singh, A. (Ambrish), Sinha, D. N. (Dhirendra Narain), Sisay, M. M. (Malede Mequanent), Skiadaresi, E. (Eirini), Smith, D. L. (David L.), Filho, A. M. (Adauto Martins Soares), Sobhiyeh, M. R. (Mohammad Reza), Sokhan, A. (Anton), Soriano, J. B. (Joan B.), Sorrie, M. B. (Muluken Bekele), Soyiri, I. N. (Ireneous N.), Spurlock, E. E. (Emma Elizabeth), Sreeramareddy, C. T. (Chandrashekhar T.), Sudaryanto, A. (Agus), Sufiyan, M. B. (Mu'awiyyah Babale), Suleria, H. A. (Hafiz Ansar Rasul), Sykes, B. L. (Bryan L.), Tabares-Seisdedos, R. (Rafael), Tabuchi, T. (Takahiro), Tadesse, D. B. (Degena Bahrey), Tarigan, I. U. (Ingan Ukur), Taye, B. (Bineyam), Tefera, Y. M. (Yonatal Mesfin), Tehrani-Banihashemi, A. (Arash), Tekelemedhin, S. W. (Shishay Wahdey), Tekle, M. G. (Merhawi Gebremedhin), Temsah, M.-H. (Mohamad-Hani), Tesfay, B. E. (Berhe Etsay), Tesfay, F. H. (Fisaha Haile), Tessema, Z. T. (Zemenu Tadesse), Thankappan, K. R. (Kavumpurathu Raman), ThekkePurakkal, A. S. (Akhil Soman), Thomas, N. (Nihal), Thompson, R. L. (Robert L.), Thomson, A. J. (Alan J.), Topor-Madry, R. (Roman), Tovani-Palone, M. R. (Marcos Roberto), Traini, E. (Eugenio), Ullah, I. (Irfan), Unnikrishnan, B. (Bhaskaran), Usman, M. S. (Muhammad Shariq), Uthman, O. A. (Olalekan A.), Uzochukwu, B. S. (Benjamin S. Chudi), Valdez, P. R. (Pascual R.), Varughese, S. (Santosh), Veisani, Y. (Yousef), Violante, F. S. (Francesco S.), Vollmer, S. (Sebastian), Whawariat, F. G. (Feleke Gebremeskel), Waheed, Y. (Yasir), Wallin, M. T. (Mitchell Taylor), Wang, Y.-P. (Yuan-Pang), Wang, Y. (Yafeng), Wangdi, K. (Kinley), Weiss, D. J. (Daniel J.), Weldesamuel, G. T. (Girmay Teklay), Werkneh, A. A. (Adhena Ayaliew), Westerman, R. (Ronny), Wiangkham, T. (Taweewat), Wiens, K. E. (Kirsten E.), Wijeratne, T. (Tissa), Wiysonge, C. S. (Charles Shey), Wolde, H. F. (Haileab Fekadu), Wondafrash, D. Z. (Dawit Zewdu), Wonde, T. E. (Tewodros Eshete), Worku, G. T. (Getasew Taddesse), Yadollahpour, A. (Ali), Jabbari, S. H. (Seyed Hossein Yahyazadeh), Yamada, T. (Tomohide), Yaseri, M. (Mehdi), Yatsuya, H. (Hiroshi), Yeshaneh, A. (Alex), Yilma, M. T. (Mekdes Tigistu), Yip, P. (Paul), Yisma, E. (Engida), Yonemoto, N. (Naohiro), Younis, M. Z. (Mustafa Z.), Yousof, H. S. (Hebat-Allah Salah A.), Yu, C. (Chuanhua), Yusefzadeh, H. (Hasan), Zadey, S. (Siddhesh), Moghadam, T. Z. (Telma Zahirian), Zaidi, Z. (Zoubida), Bin Zaman, S. (Sojib), Zamani, M. (Mohammad), Zandian, H. (Hamed), Zar, H. J. (Heather J.), Zerfu, T. A. (Taddese Alemu), Zhang, Y. (Yunquan), Ziapour, A. (Arash), Zodpey, S. (Sanjay), Zuniga, Y. M. (Yves Miel H.), Hay, S. I. (Simon, I), and Reiner, R. C. (Robert C., Jr.)

Abstract

Background: Universal access to safe drinking water and sanitation facilities is an essential human right, recognised in the Sustainable Development Goals as crucial for preventing disease and improving human wellbeing. Comprehensive, high-resolution estimates are important to inform progress towards achieving this goal. We aimed to produce high-resolution geospatial estimates of access to drinking water and sanitation facilities. Methods: We used a Bayesian geostatistical model and data from 600 sources across more than 88 low-income and middle-income countries (LMICs) to estimate access to drinking water and sanitation facilities on continuous continent-wide surfaces from 2000 to 2017, and aggregated results to policy-relevant administrative units. We estimated mutually exclusive and collectively exhaustive subcategories of facilities for drinking water (piped water on or off premises, other improved facilities, unimproved, and surface water) and sanitation facilities (septic or sewer sanitation, other improved, unimproved, and open defecation) with use of ordinal regression. We also estimated the number of diarrhoeal deaths in children younger than 5 years attributed to unsafe facilities and estimated deaths that were averted by increased access to safe facilities in 2017, and analysed geographical inequality in access within LMICs. Findings: Across LMICs, access to both piped water and improved water overall increased between 2000 and 2017, with progress varying spatially. For piped water, the safest water facility type, access increased from 40·0% (95% uncertainty interval [UI] 39·4–40·7) to 50·3% (50·0–50·5), but was lowest in sub-Saharan Africa, where access to piped water was mostly concentrated in urban centres. Access to both sewer or septic sanitation and improved sanitation overall also increased across all LMICs during the study period. For sewer or septic sanitation, access was 46·3% (95% UI 46·1–46·5) in 2017, compared with 28·7% (28·5–29·0)

Published
2020

25. Mapping geographical inequalities in oral rehydration therapy coverage in low-income and middle-income countries, 2000–17

Author

Wiens, K. E. (Kirsten E.), Lindstedt, P. A. (Paulina A.), Blacker, B. F. (Brigette F.), Johnson, K. B. (Kimberly B.), Baumann, M. M. (Mathew M.), Schaeffer, L. E. (Lauren E.), Abbastabar, H. (Hedayat), Abd-Allah, F. (Foad), Abdelalim, A. (Ahmed), Abdollahpour, I. (Ibrahim), Abegaz, K. H. (Kedir Hussein), Abejie, A. N. (Ayenew Negesse), Abreu, L. G. (Lucas Guimaraes), Abrigo, M. R. (Michael R. M.), Abualhasan, A. (Ahmed), Accrombessi, M. M. (Manfred Mario Kokou), Acharya, D. (Dilaram), Adabi, M. (Maryam), Adamu, A. A. (Abdu A.), Adebayo, O. M. (Oladimeji M.), Adedoyin, R. A. (Rufus Adesoji), Adekanmbi, V. (Victor), Adetokunboh, O. O. (Olatunji O.), Adhena, B. M. (Beyene Meressa), Afarideh, M. (Mohsen), Ahmad, S. (Sohail), Ahmadi, K. (Keivan), Ahmed, A. E. (Anwar E.), Ahmed, M. B. (Muktar Beshir), Ahmed, R. (Rushdia), Akalu, T. Y. (Temesgen Yihunie), Alahdab, F. (Fares), Al-Aly, Z. (Ziyad), Alam, N. (Noore), Alam, S. (Samiah), Alamene, G. M. (Genet Melak), Alanzi, T. M. (Turki M.), Alcalde-Rabanal, J. E. (Jacqueline Elizabeth), Ali, B. A. (Beriwan Abdulqadir), Alijanzadeh, M. (Mehran), Alipour, V. (Vahid), Aljunid, S. M. (Syed Mohamed), Almasi, A. (Ali), Almasi-Hashiani, A. (Amir), Al-Mekhlafi, H. M. (Hesham M.), Altirkawi, K. A. (Khalid A.), Alvis-Guzman, N. (Nelson), Alvis-Zakzuk, N. J. (Nelson J.), Amini, S. (Saeed), Amit, A. M. (Arianna Maever L.), Andrei, C. L. (Catalina Liliana), Anjomshoa, M. (Mina), Anoushiravani, A. (Amir), Ansari, F. (Fereshteh), Antonio, C. A. (Carl Abelardo T.), Antony, B. (Benny), Antriyandarti, E. (Ernoiz), Arabloo, J. (Jalal), Aref, H. M. (Hany Mohamed Amin), Aremu, O. (Olatunde), Armoon, B. (Bahram), Arora, A. (Amit), Aryal, K. K. (Krishna K.), Arzani, A. (Afsaneh), Asadi-Aliabadi, M. (Mehran), Atalay, H. T. (Hagos Tasew), Athari, S. S. (Seyyed Shamsadin), Athari, S. M. (Seyyede Masoume), Atre, S. R. (Sachin R.), Ausloos, M. (Marcel), Awoke, N. (Nefsu), Quintanilla, B. P. (Beatriz Paulina Ayala), Ayano, G. (Getinet), Ayanore, M. A. (Martin Amogre), Aynalem, Y. A. (Yared Asmare), Azari, S. (Samad), Azzopardi, P. S. (Peter S.), Babaee, E. (Ebrahim), Babalola, T. K. (Tesleem Kayode), Badawi, A. (Alaa), Bairwa, M. (Mohan), Bakkannavar, S. M. (Shankar M.), Balakrishnan, S. (Senthilkumar), Bali, A. G. (Ayele Geleto), Banach, M. (Maciej), Banoub, J. A. (Joseph Adel Mattar), Barac, A. (Aleksandra), Barnighausen, T. W. (Till Winfried), Basaleem, H. (Huda), Basu, S. (Sanjay), Bay, V. D. (Vo Dinh), Bayati, M. (Mohsen), Baye, E. (Estifanos), Bedi, N. (Neeraj), Beheshti, M. (Mahya), Behzadifar, M. (Masoud), Behzadifar, M. (Meysam), Bekele, B. B. (Bayu Begashaw), Belayneh, Y. M. (Yaschilal Muche), Bell, M. L. (Michelle L.), Bennett, D. A. (Derrick A.), Berbada, D. A. (Dessalegn Ajema), Bernstein, R. S. (Robert S.), Bhat, A. G. (Anusha Ganapati), Bhattacharyya, K. (Krittika), Bhattarai, S. (Suraj), Bhaumik, S. (Soumyadeep), Bhutta, Z. A. (Zulfiqar A.), Bijani, A. (Ali), Bikbov, B. (Boris), Birihane, B. M. (Binyam Minuye), Biswas, R. K. (Raaj Kishore), Bohlouli, S. (Somayeh), Bojia, H. A. (Hunduma Amensisa), Boufous, S. (Soufiane), Brady, O. J. (Oliver J.), Bragazzi, N. L. (Nicola Luigi), Briko, A. N. (Andrey Nikolaevich), Briko, N. I. (Nikolay Ivanovich), Britton, G. B. (Gabrielle B.), Nagaraja, S. B. (Sharath Burugina), Busse, R. (Reinhard), Butt, Z. A. (Zahid A.), Camera, L. A. (Luis Alberto), Campos-Nonato, I. R. (Ismael R.), Cano, J. (Jorge), Car, J. (Josip), Cardenas, R. (Rosario), Carvalho, F. (Felix), Castaneda-Orjuela, C. A. (Carlos A.), Castro, F. (Franz), Chanie, W. F. (Wagaye Fentahun), Chatterjee, P. (Pranab), Chattu, V. K. (Vijay Kumar), Chichiabellu, T. Y. (Tesfaye Yitna), Chin, K. L. (Ken Lee), Christopher, D. J. (Devasahayam J.), Chu, D.-T. (Dinh-Toi), Cormier, N. M. (Natalie Maria), Costa, V. M. (Vera Marisa), Culquichicon, C. (Carlos), Daba, M. S. (Matiwos Soboka), Damiani, G. (Giovanni), Dandona, L. (Lalit), Dandona, R. (Rakhi), Dang, A. K. (Anh Kim), Darwesh, A. M. (Aso Mohammad), Darwish, A. H. (Amira Hamed), Daryani, A. (Ahmad), Das, J. K. (Jai K.), Das Gupta, R. (Rajat), Dash, A. P. (Aditya Prasad), Davey, G. (Gail), Davila-Cervantes, C. A. (Claudio Alberto), Davis, A. C. (Adrian C.), Davitoiu, D. V. (Dragos Virgil), De la Hoz, F. P. (Fernando Pio), Demis, A. B. (Asmamaw Bizuneh), Demissie, D. B. (Dereje Bayissa), Demissie, G. D. (Getu Debalkie), Demoz, G. T. (Gebre Teklemariam), Denova-Gutierrez, E. (Edgar), Deribe, K. (Kebede), Desalew, A. (Assefa), Deshpande, A. (Aniruddha), Dharmaratne, S. D. (Samath Dhamminda), Dhillon, P. (Preeti), Dhimal, M. (Meghnath), Dhungana, G. P. (Govinda Prasad), Diaz, D. (Daniel), Dipeolu, I. O. (Isaac Oluwafemi), Djalalinia, S. (Shirin), Doyle, K. E. (Kerrie E.), Dubljanin, E. (Eleonora), Duko, B. (Bereket), Duraes, A. R. (Andre Rodrigues), Kalan, M. E. (Mohammad Ebrahimi), Edinur, H. A. (Hisham Atan), Effiong, A. (Andem), Eftekhari, A. (Aziz), El Nahas, N. (Nevine), El Sayed, I. (Iman), Zaki, M. E. (Maysaa El Sayed), El Tantawi, M. (Maha), Elema, T. B. (Teshome Bekele), Elhabashy, H. R. (Hala Rashad), El-Jaafary, S. I. (Shaimaa I.), Elkout, H. (Hajer), Elsharkawy, A. (Aisha), Elyazar, I. R. (Iqbal R. F.), Endalamaw, A. (Aklilu), Endalew, D. A. (Daniel Adane), Eskandarieh, S. (Sharareh), Esteghamati, A. (Alireza), Esteghamati, S. (Sadaf), Etemadi, A. (Arash), Ezekannagha, O. (Oluchi), Fareed, M. (Mohammad), Faridnia, R. (Roghiyeh), Farzadfar, F. (Farshad), Fazlzadeh, M. (Mehdi), Feigin, V. L. (Valery L.), Fereshtehnejad, S.-M. (Seyed-Mohammad), Fernandes, E. (Eduarda), Filip, I. (Irina), Fischer, F. (Florian), Foigt, N. A. (Nataliya A.), Folayan, M. O. (Morenike Oluwatoyin), Foroutan, M. (Masoud), Franklin, R. C. (Richard Charles), Fukumoto, T. (Takeshi), Gad, M. M. (Mohamed M.), Gayesa, R. T. (Reta Tsegaye), Gebre, T. (Teshome), Gebremedhin, K. B. (Ketema Bizuwork), Gebremeskel, G. G. (Gebreamlak Gebremedhn), Gesesew, H. A. (Hailay Abrha), Gezae, K. E. (Kebede Embaye), Ghadiri, K. (Keyghobad), Ghashghaee, A. (Ahmad), Ghimire, P. R. (Pramesh Raj), Gill, P. S. (Paramjit Singh), Gill, T. K. (Tiffany K.), Ginindza, T. G. (Themba G.), Gomes, N. G. (Nelson G. M.), Gopalani, S. V. (Sameer Vali), Goulart, A. C. (Alessandra C.), Goulart, B. N. (Barbara Niegia Garcia), Grada, A. (Ayman), Gubari, M. I. (Mohammed Ibrahim Mohialdeen), Gugnani, H. C. (Harish Chander), Guido, D. (Davide), Guimaraes, R. A. (Rafael Alves), Guo, Y. (Yuming), Gupta, R. (Rajeev), Hafezi-Nejad, N. (Nima), Haile, D. H. (Dessalegn H.), Hailu, G. B. (Gessessew Bugssa), Haj-Mirzaian, A. (Arvin), Haj-Mirzaian, A. (Arya), Hamadeh, R. R. (Randah R.), Hamidi, S. (Samer), Handiso, D. W. (Demelash Woldeyohannes), Haririan, H. (Hamidreza), Hariyani, N. (Ninuk), Hasaballah, A. I. (Ahmed I.), Hasan, M. M. (Md Mehedi), Hasanpoor, E. (Edris), Hasanzadeh, A. (Amir), Hassankhani, H. (Hadi), Hassen, H. Y. (Hamid Yimam), Hegazy, M. I. (Mohamed I.), Heibati, B. (Behzad), Heidari, B. (Behnam), Hendrie, D. (Delia), Henry, N. J. (Nathaniel J.), Herteliu, C. (Claudiu), Heydarpour, F. (Fatemeh), de Hidru, H. D. (Hagos Degefa), Hird, T. R. (Thomas R.), Hoang, C. L. (Chi Linh), Rad, E. H. (Enayatollah Homaie), Hoogar, P. (Praveen), Hoseini, M. (Mohammad), Hossain, N. (Naznin), Hosseini, M. (Mostafa), Hosseinzadeh, M. (Mehdi), Househ, M. (Mowafa), Hsairi, M. (Mohamed), Hu, G. (Guoqing), Hussen, M. M. (Mohammedaman Mama), Ibitoye, S. E. (Segun Emmanuel), Igumbor, E. U. (Ehimario U.), Ilesanmi, O. S. (Olayinka Stephen), Ilic, M. D. (Milena D.), Imani-Nasab, M. H. (Mohammad Hasan), Iqbal, U. (Usman), Irvani, S. S. (Seyed Sina Naghibi), Islam, S. M. (Sheikh Mohammed Shariful), Iwu, C. J. (Chinwe Juliana), Izadi, N. (Neda), Jaca, A. (Anelisa), Jahanmehr, N. (Nader), Jakovljevic, M. (Mihajlo), Jalali, A. (Amir), Jayatilleke, A. U. (Achala Upendra), Jha, R. P. (Ravi Prakash), Jha, V. (Vivekanand), Ji, J. S. (John S.), Jonas, J. B. (Jost B.), Jozwiak, J. J. (Jacek Jerzy), Kabir, A. (Ali), Kabir, Z. (Zubair), Kahsay, A. (Amaha), Kalani, H. (Hamed), Kanchan, T. (Tanuj), Matin, B. K. (Behzad Karami), Karch, A. (Andre), Karim, M. A. (Mohd Anisul), Karki, H. K. (Hamidreza Karimi-Sari Surendra), Kasaeian, A. (Amir), Kasahun, G. G. (Gebremicheal Gebreslassie), Kasahun, Y. C. (Yawukal Chane), Kasaye, H. K. (Habtamu Kebebe), Kassa, G. G. (Gebrehiwot G.), Kassa, G. M. (Getachew Mullu), Kayode, G. A. (Gbenga A.), Karyani, A. K. (Ali Kazemi), Kebede, M. M. (Mihiretu M.), Keiyoro, P. N. (Peter Njenga), Kelbore, A. G. (Abraham Getachew), Kengne, A. P. (Andre Pascal), Ketema, D. B. (Daniel Bekele), Khader, Y. S. (Yousef Saleh), Khafaie, M. A. (Morteza Abdullatif), Khalid, N. (Nauman), Khalilov, R. (Rovshan), Khan, E. A. (Ejaz Ahmad), Khan, J. (Junaid), Khan, M. N. (Md Nuruzzaman), Khan, M. S. (Muhammad Shahzeb), Khatab, K. (Khaled), Khater, A. M. (Amir M.), Khater, M. M. (Mona M.), Khayamzadeh, M. (Maryam), Khazaei, M. (Mohammad), Khazaei, S. (Salman), Khosravi, M. H. (Mohammad Hossein), Khubchandani, J. (Jagdish), Kiadaliri, A. (Ali), Kim, Y. J. (Yun Jin), Kimokoti, R. W. (Ruth W.), Kisa, A. (Adnan), Kisa, S. (Sezer), Kissoon, N. (Niranjan), Shivakumar, K. M. (K. M.), Kochhar, S. (Sonali), Kolola, T. (Tufa), Komaki, H. (Hamidreza), Kosen, S. (Soewarta), Koul, P. A. (Parvaiz A.), Koyanagi, A. (Ai), Kraemer, M. U. (Moritz U. G.), Krishan, K. (Kewal), Kugbey, N. (Nuworza), Kumar, G. A. (G. Anil), Kumar, M. (Manasi), Kumar, P. (Pushpendra), Kusuma, V. K. (Vivek Kumar Dian), La Vecchia, C. (Carlo), Lacey, B. (Ben), Lad, S. D. (Sheetal D.), Lal, D. K. (Dharmesh Kumar), Lam, F. (Felix), Lami, F. H. (Faris Hasan), Lamichhane, P. (Prabhat), Lansingh, V. C. (Van Charles), Lasrado, S. (Savita), Laxmaiah, A. (Avula), Lee, P. H. (Paul H.), LeGrand, K. E. (Kate E.), Leili, M. (Mostafa), Lenjebo, T. L. (Tsegaye Lolaso), Leshargie, C. T. (Cheru Tesema), Levine, A. J. (Aubrey J.), Li, S. (Shanshan), Linn, S. (Shai), Liu, S. (Shiwei), Liu, S. (Simin), Lodha, R. (Rakesh), Longbottom, J. (Joshua), Lopez, J. C. (Jaifred Christian F.), Abd El Razek, H. M. (Hassan Magdy), Abd El Razek, M. M. (Muhammed Magdy), Prasad, D. R. (D. R. Mahadeshwara), Mahasha, P. W. (Phetole Walter), Mahotra, N. B. (Narayan B.), Majeed, A. (Azeem), Malekzadeh, R. (Reza), Malta, D. C. (Deborah Carvalho), Mamun, A. A. (Abdullah A.), Manafi, N. (Navid), Manda, A. L. (Ana Laura), Manohar, N. D. (Narendar Dawani Dawanu), Mansournia, M. A. (Mohammad Ali), Mapoma, C. C. (Chabila Christopher), Maravilla, J. C. (Joemer C.), Martinez, G. (Gabriel), Martini, S. (Santi), Martins-Melo, F. R. (Francisco Rogerlandio), Masaka, A. (Anthony), Massenburg, B. B. (Benjamin Ballard), Mathur, M. R. (Manu Raj), Mayala, B. K. (Benjamin K.), Mazidi, M. (Mohsen), McAlinden, C. (Colm), Meharie, B. G. (Birhanu Geta), Mehndiratta, M. M. (Man Mohan), Mehta, K. M. (Kala M.), Mekonnen, T. C. (Tefera Chane), Meles, G. G. (Gebrekiros Gebremichael), Memiah, P. T. (Peter T. N.), Memish, Z. A. (Ziad A.), Mendoza, W. (Walter), Menezes, R. G. (Ritesh G.), Mereta, S. T. (Seid Tiku), Meretoja, T. J. (Tuomo J.), Mestrovic, T. (Tomislav), Miazgowski, B. (Bartosz), Mihretie, K. M. (Kebadnew Mulatu), Miller, T. R. (Ted R.), Mini, G. K. (G. K.), Mirrakhimov, E. M. (Erkin M.), Moazen, B. (Babak), Mohajer, B. (Bahram), Mohamadi-Bolbanabad, A. (Amjad), Mohammad, D. K. (Dara K.), Mohammad, K. A. (Karzan Abdulmuhsin), Mohammad, Y. (Yousef), Mezerji, N. M. (Naser Mohammad Gholi), Mohammadibakhsh, R. (Roghayeh), Mohammadifard, N. (Noushin), Mohammed, J. A. (Jemal Abdu), Mohammed, S. (Shafiu), Mohebi, F. (Farnam), Mokdad, A. H. (Ali H.), Molokhia, M. (Mariam), Monasta, L. (Lorenzo), Moodley, Y. (Yoshan), Moore, C. E. (Catrin E.), Moradi, G. (Ghobad), Moradi, M. (Masoud), Moradi-Joo, M. (Mohammad), Moradi-Lakeh, M. (Maziar), Moraga, P. (Paula), Morales, L. (Linda), Velasquez, I. M. (Ilais Moreno), Mosapour, A. (Abbas), Mouodi, S. (Simin), Mousavi, S. M. (Seyyed Meysam), Mozaffor, M. (Miliva), Muchie, K. F. (Kindie Fentahun), Mulaw, G. F. (Getahun Fentaw), Munro, S. B. (Sandra B.), Muriithi, M. K. (Moses K.), Murray, C. J. (Christoper J. L.), Murthy, G. V. (G. V. S.), Musa, K. I. (Kamarul Imran), Mustafa, G. (Ghulam), Muthupandian, S. (Saravanan), Nabhan, A. F. (Ashraf F.), Naderi, M. (Mehdi), Nagarajan, A. J. (Ahamarshan Jayaraman), Naidoo, K. S. (Kovin S.), Naik, G. (Gurudatta), Najafi, F. (Farid), Nangia, V. (Vinay), Nansseu, J. R. (Jobert Richie), Nascimento, B. R. (Bruno Ramos), Nazari, J. (Javad), Ndwandwe, D. E. (Duduzile Edith), Negoi, I. (Ionut), Netsere, H. B. (Henok Biresaw), Ngunjiri, J. W. (Josephine W.), Nguyen, C. T. (Cuong Tat), Nguyen, H. L. (Huong Lan Thi), Nguyen, T. H. (Trang Huyen), Nigatu, D. (Dabere), Nigatu, S. G. (Solomon Gedlu), Ningrum, D. N. (Dina Nur Anggraini), Nnaji, C. A. (Chukwudi A.), Nojomi, M. (Marzieh), Nong, V. M. (Vuong Minh), Norheim, O. F. (Ole F.), Noubiap, J. J. (Jean Jacques), Motlagh, S. N. (Soraya Nouraei), Oancea, B. (Bogdan), Ogah, O. S. (Okechukwu Samuel), Ogbo, F. A. (Felix Akpojene), Oh, I.-H. (In-Hwan), Olagunju, A. T. (Andrew T.), Olagunju, T. O. (Tinuke O.), Olusanya, B. O. (Bolajoko Olubukunola), Olusanya, J. O. (Jacob Olusegun), Onwujekwe, O. E. (Obinna E.), Oren, E. (Eyal), Ortega-Altamirano, D. V. (Doris V.), Osarenotor, O. (Osayomwanbo), Osei, F. B. (Frank B.), Owolabi, M. O. (Mayowa O.), Mahesh, P. A. (P. A.), Padubidri, J. R. (Jagadish Rao), Pakhale, S. (Smita), Patel, S. K. (Sangram Kishor), Paternina-Caicedo, A. J. (Angel J.), Pathak, A. (Ashish), Patton, G. C. (George C.), Paudel, D. (Deepak), Paulos, K. (Kebreab), Pepito, V. C. (Veincent Christian Filipino), Pereira, A. (Alexandre), Perico, N. (Norberto), Pervaiz, A. (Aslam), Pescarini, J. M. (Julia Moreira), Piroozi, B. (Bakhtiar), Pirsaheb, M. (Meghdad), Postma, M. J. (Maarten J.), Pourjafar, H. (Hadi), Pourmalek, F. (Farshad), Pourshams, A. (Akram), Poustchi, H. (Hossein), Prada, S. I. (Sergio I.), Prasad, N. (Narayan), Preotescu, L. (Liliana), Quintana, H. (Hedley), Rabiee, N. (Navid), Radfar, A. (Amir), Rafiei, A. (Alireza), Rahim, F. (Fakher), Rahimi-Movaghar, A. (Afarin), Rahimi-Movaghar, V. (Vafa), Rahman, M. H. (Mohammad Hifz Ur), Rahman, M. A. (Muhammad Aziz), Rahman, S. (Shafiur), Rajati, F. (Fatemeh), Rana, S. M. (Saleem Muhammad), Ranabhat, C. L. (Chhabi Lal), Rasella, D. (Davide), Rawaf, D. L. (David Laith), Rawaf, S. (Salman), Rawal, L. (Lal), Rawasia, W. F. (Wasiq Faraz), Renjith, V. (Vishnu), Renzaho, A. M. (Andre M. N.), Resnikoff, S. (Serge), Reta, M. A. (Melese Abate), Rezaei, N. (Negar), Rezai, M. S. (Mohammad Sadegh), Riahi, S. M. (Seyed Mohammad), Ribeiro, A. I. (Ana Isabel), Rickard, J. (Jennifer), Rios-Blancas, M. (Maria), Roever, L. (Leonardo), Ronfani, L. (Luca), Roro, E. M. (Elias Merdassa), Ross, J. M. (Jennifer M.), Rubagotti, E. (Enrico), Rubino, S. (Salvatore), Saad, A. M. (Anas M.), Sabde, Y. D. (Yogesh Damodar), Sabour, S. (Siamak), Sadeghi, E. (Ehsan), Safari, Y. (Yahya), Safari-Faramani, R. (Roya), Sagar, R. (Rajesh), Sahebkar, A. (Amirhossein), Sahraian, M. A. (Mohammad Ali), Sajadi, S. M. (S. Mohammad), Salahshoor, M. R. (Mohammad Reza), Salam, N. (Nasir), Salamati, P. (Payman), Salem, H. (Hosni), Salem, M. R. (Marwa Rashad), Salimi, Y. (Yahya), Salimzadeh, H. (Hamideh), Samy, A. M. (Abdallah M.), Sanabria, J. (Juan), Santric-Milicevic, M. M. (Milena M.), Jose, B. P. (Bruno Piassi Sao), Saraswathy, S. Y. (Sivan Yegnanarayana Iyer), Sarkar, K. (Kaushik), Sarker, A. R. (Abdur Razzaque), Sarrafzadegan, N. (Nizal), Sartorius, B. (Benn), Sathian, B. (Brijesh), Sathish, T. (Thirunavukkarasu), Sawhney, M. (Monika), Saxena, S. (Sonia), Schwebel, D. C. (David C.), Senbeta, A. M. (Anbissa Muleta), Senthilkumaran, S. (Subramanian), Sepanlou, S. G. (Sadaf G.), Servan-Mori, E. (Edson), Shabaninejad, H. (Hosein), Shafieesabet, A. (Azadeh), Shaikh, M. A. (Masood Ali), Shalash, A. S. (Ali S.), Shallo, S. A. (Seifadin Ahmed), Shams-Beyranvand, M. (Mehran), Shamsi, M. (MohammadBagher), Shamsizadeh, M. (Morteza), Shannawaz, M. (Mohammed), Sharafi, K. (Kiomars), Sharifi, H. (Hamid), Shehata, H. S. (Hatem Samir), Sheikh, A. (Aziz), Shetty, B. S. (B. Suresh Kumar), Shibuya, K. (Kenji), Shiferaw, W. S. (Wondimeneh Shibabaw), Shifti, D. M. (Desalegn Markos), Shigematsu, M. (Mika), Il Shin, J. (Jae), Shiri, R. (Rahman), Shirkoohi, R. (Reza), Siabani, S. (Soraya), Siddiqi, T. J. (Tariq Jamal), Silva, D. A. (Diego Augusto Santos), Singh, A. (Ambrish), Singh, J. A. (Jasvinder A.), Singh, N. P. (Narinder Pal), Singh, V. (Virendra), Sisay, M. M. (Malede Mequanent), Skiadaresi, E. (Eirini), Sobhiyeh, M. R. (Mohammad Reza), Sokhan, A. (Anton), Soltani, S. (Shahin), Somayaji, R. (Ranjani), Soofi, M. (Moslem), Sorrie, M. B. (Muluken Bekele), Soyiri, I. N. (Ireneous N.), Sreeramareddy, C. T. (Chandrashekhar T.), Sudaryanto, A. (Agus), Sufiyan, M. B. (Mu'awiyyah Babale), Suleria, H. A. (Hafiz Ansar Rasul), Sultana, M. (Marufa), Sunguya, B. F. (Bruno Fokas), Sykes, B. L. (Bryan L.), Tabares-Seisdedos, R. (Rafael), Tabuchi, T. (Takahiro), Tadesse, D. B. (Degena Bahrey), Tarigan, I. U. (Ingan Ukur), Tasew, A. A. (Aberash Abay), Tefera, Y. M. (Yonatal Mesfin), Tekle, M. G. (Merhawi Gebremedhin), Temsah, M.-H. (Mohamad-Hani), Tesfay, B. E. (Berhe Etsay), Tesfay, F. H. (Fisaha Haile), Tessema, B. (Belay), Tessema, Z. T. (Zemenu Tadesse), Thankappan, K. R. (Kavumpurathu Raman), Thomas, N. (Nihal), Toma, A. (Alemayehu), Topor-Madry, R. (Roman), Tovani-Palone, M. R. (Marcos Roberto), Traini, E. (Eugenio), Tran, B. X. (Bach Xuan), Tran, K. B. (Khanh Bao), Ullah, I. (Irfan), Unnikrishnan, B. (Bhaskaran), Usman, M. S. (Muhammad Shariq), Uzochukwu, B. S. (Benjamin S. Chudi), Valdez, P. R. (Pascual R.), Varughese, S. (Santosh), Violante, F. S. (Francesco S.), Vollmer, S. (Sebastian), Hawariat, F. G. (Feleke Gebremeskel W.), Waheed, Y. (Yasir), Wallin, M. T. (Mitchell Taylor), Wang, Y. (Yafeng), Wang, Y.-P. (Yuan-Pang), Weaver, M. (Marcia), Weji, B. G. (Bedilu Girma), Weldesamuel, G. T. (Girmay Teklay), Welgan, C. A. (Catherine A.), Werdecker, A. (Andrea), Westerman, R. (Ronny), Wiangkham, T. (Taweewat), Wiysonge, C. S. (Charles Shey), Wolde, H. F. (Haileab Fekadu), Wondafrash, D. Z. (Dawit Zewdu), Wonde, T. E. (Tewodros Eshete), Worku, G. T. (Getasew Taddesse), Wu, A.-M. (Ai-Min), Xu, G. (Gelin), Yadollahpour, A. (Ali), Jabbari, S. H. (Seyed Hossein Yahyazadeh), Yamada, T. (Tomohide), Yatsuya, H. (Hiroshi), Yeshaneh, A. (Alex), Yilgwan, C. S. (Christopher Sabo), Yilma, M. T. (Mekdes Tigistu), Yip, P. (Paul), Yisma, E. (Engida), Yonemoto, N. (Naohiro), Yoon, S.-J. (Seok-Jun), Younis, M. Z. (Mustafa Z.), Yousefifard, M. (Mahmoud), Yousof, H. S. (Hebat-Allah Salah A.), Yu, C. (Chuanhua), Yusefzadeh, H. (Hasan), Zadey, S. (Siddhesh), Zaidi, Z. (Zoubida), Bin Zaman, S. (Sojib), Zamani, M. (Mohammad), Zandian, H. (Hamed), Zepro, N. B. (Nejimu Biza), Zerfu, T. A. (Taddese Alemu), Zhang, Y. (Yunquan), Zhao, X. G. (Xiu-Ju George), Ziapour, A. (Arash), Zodpey, S. (Sanjay), Zuniga, Y. M. (Yves Miel H.), Hay, S. I. (Simon I.), Reiner, R. C. (Robert C., Jr.), Wiens, K. E. (Kirsten E.), Lindstedt, P. A. (Paulina A.), Blacker, B. F. (Brigette F.), Johnson, K. B. (Kimberly B.), Baumann, M. M. (Mathew M.), Schaeffer, L. E. (Lauren E.), Abbastabar, H. (Hedayat), Abd-Allah, F. (Foad), Abdelalim, A. (Ahmed), Abdollahpour, I. (Ibrahim), Abegaz, K. H. (Kedir Hussein), Abejie, A. N. (Ayenew Negesse), Abreu, L. G. (Lucas Guimaraes), Abrigo, M. R. (Michael R. M.), Abualhasan, A. (Ahmed), Accrombessi, M. M. (Manfred Mario Kokou), Acharya, D. (Dilaram), Adabi, M. (Maryam), Adamu, A. A. (Abdu A.), Adebayo, O. M. (Oladimeji M.), Adedoyin, R. A. (Rufus Adesoji), Adekanmbi, V. (Victor), Adetokunboh, O. O. (Olatunji O.), Adhena, B. M. (Beyene Meressa), Afarideh, M. (Mohsen), Ahmad, S. (Sohail), Ahmadi, K. (Keivan), Ahmed, A. E. (Anwar E.), Ahmed, M. B. (Muktar Beshir), Ahmed, R. (Rushdia), Akalu, T. Y. (Temesgen Yihunie), Alahdab, F. (Fares), Al-Aly, Z. (Ziyad), Alam, N. (Noore), Alam, S. (Samiah), Alamene, G. M. (Genet Melak), Alanzi, T. M. (Turki M.), Alcalde-Rabanal, J. E. (Jacqueline Elizabeth), Ali, B. A. (Beriwan Abdulqadir), Alijanzadeh, M. (Mehran), Alipour, V. (Vahid), Aljunid, S. M. (Syed Mohamed), Almasi, A. (Ali), Almasi-Hashiani, A. (Amir), Al-Mekhlafi, H. M. (Hesham M.), Altirkawi, K. A. (Khalid A.), Alvis-Guzman, N. (Nelson), Alvis-Zakzuk, N. J. (Nelson J.), Amini, S. (Saeed), Amit, A. M. (Arianna Maever L.), Andrei, C. L. (Catalina Liliana), Anjomshoa, M. (Mina), Anoushiravani, A. (Amir), Ansari, F. (Fereshteh), Antonio, C. A. (Carl Abelardo T.), Antony, B. (Benny), Antriyandarti, E. (Ernoiz), Arabloo, J. (Jalal), Aref, H. M. (Hany Mohamed Amin), Aremu, O. (Olatunde), Armoon, B. (Bahram), Arora, A. (Amit), Aryal, K. K. (Krishna K.), Arzani, A. (Afsaneh), Asadi-Aliabadi, M. (Mehran), Atalay, H. T. (Hagos Tasew), Athari, S. S. (Seyyed Shamsadin), Athari, S. M. (Seyyede Masoume), Atre, S. R. (Sachin R.), Ausloos, M. (Marcel), Awoke, N. (Nefsu), Quintanilla, B. P. (Beatriz Paulina Ayala), Ayano, G. (Getinet), Ayanore, M. A. (Martin Amogre), Aynalem, Y. A. (Yared Asmare), Azari, S. (Samad), Azzopardi, P. S. (Peter S.), Babaee, E. (Ebrahim), Babalola, T. K. (Tesleem Kayode), Badawi, A. (Alaa), Bairwa, M. (Mohan), Bakkannavar, S. M. (Shankar M.), Balakrishnan, S. (Senthilkumar), Bali, A. G. (Ayele Geleto), Banach, M. (Maciej), Banoub, J. A. (Joseph Adel Mattar), Barac, A. (Aleksandra), Barnighausen, T. W. (Till Winfried), Basaleem, H. (Huda), Basu, S. (Sanjay), Bay, V. D. (Vo Dinh), Bayati, M. (Mohsen), Baye, E. (Estifanos), Bedi, N. (Neeraj), Beheshti, M. (Mahya), Behzadifar, M. (Masoud), Behzadifar, M. (Meysam), Bekele, B. B. (Bayu Begashaw), Belayneh, Y. M. (Yaschilal Muche), Bell, M. L. (Michelle L.), Bennett, D. A. (Derrick A.), Berbada, D. A. (Dessalegn Ajema), Bernstein, R. S. (Robert S.), Bhat, A. G. (Anusha Ganapati), Bhattacharyya, K. (Krittika), Bhattarai, S. (Suraj), Bhaumik, S. (Soumyadeep), Bhutta, Z. A. (Zulfiqar A.), Bijani, A. (Ali), Bikbov, B. (Boris), Birihane, B. M. (Binyam Minuye), Biswas, R. K. (Raaj Kishore), Bohlouli, S. (Somayeh), Bojia, H. A. (Hunduma Amensisa), Boufous, S. (Soufiane), Brady, O. J. (Oliver J.), Bragazzi, N. L. (Nicola Luigi), Briko, A. N. (Andrey Nikolaevich), Briko, N. I. (Nikolay Ivanovich), Britton, G. B. (Gabrielle B.), Nagaraja, S. B. (Sharath Burugina), Busse, R. (Reinhard), Butt, Z. A. (Zahid A.), Camera, L. A. (Luis Alberto), Campos-Nonato, I. R. (Ismael R.), Cano, J. (Jorge), Car, J. (Josip), Cardenas, R. (Rosario), Carvalho, F. (Felix), Castaneda-Orjuela, C. A. (Carlos A.), Castro, F. (Franz), Chanie, W. F. (Wagaye Fentahun), Chatterjee, P. (Pranab), Chattu, V. K. (Vijay Kumar), Chichiabellu, T. Y. (Tesfaye Yitna), Chin, K. L. (Ken Lee), Christopher, D. J. (Devasahayam J.), Chu, D.-T. (Dinh-Toi), Cormier, N. M. (Natalie Maria), Costa, V. M. (Vera Marisa), Culquichicon, C. (Carlos), Daba, M. S. (Matiwos Soboka), Damiani, G. (Giovanni), Dandona, L. (Lalit), Dandona, R. (Rakhi), Dang, A. K. (Anh Kim), Darwesh, A. M. (Aso Mohammad), Darwish, A. H. (Amira Hamed), Daryani, A. (Ahmad), Das, J. K. (Jai K.), Das Gupta, R. (Rajat), Dash, A. P. (Aditya Prasad), Davey, G. (Gail), Davila-Cervantes, C. A. (Claudio Alberto), Davis, A. C. (Adrian C.), Davitoiu, D. V. (Dragos Virgil), De la Hoz, F. P. (Fernando Pio), Demis, A. B. (Asmamaw Bizuneh), Demissie, D. B. (Dereje Bayissa), Demissie, G. D. (Getu Debalkie), Demoz, G. T. (Gebre Teklemariam), Denova-Gutierrez, E. (Edgar), Deribe, K. (Kebede), Desalew, A. (Assefa), Deshpande, A. (Aniruddha), Dharmaratne, S. D. (Samath Dhamminda), Dhillon, P. (Preeti), Dhimal, M. (Meghnath), Dhungana, G. P. (Govinda Prasad), Diaz, D. (Daniel), Dipeolu, I. O. (Isaac Oluwafemi), Djalalinia, S. (Shirin), Doyle, K. E. (Kerrie E.), Dubljanin, E. (Eleonora), Duko, B. (Bereket), Duraes, A. R. (Andre Rodrigues), Kalan, M. E. (Mohammad Ebrahimi), Edinur, H. A. (Hisham Atan), Effiong, A. (Andem), Eftekhari, A. (Aziz), El Nahas, N. (Nevine), El Sayed, I. (Iman), Zaki, M. E. (Maysaa El Sayed), El Tantawi, M. (Maha), Elema, T. B. (Teshome Bekele), Elhabashy, H. R. (Hala Rashad), El-Jaafary, S. I. (Shaimaa I.), Elkout, H. (Hajer), Elsharkawy, A. (Aisha), Elyazar, I. R. (Iqbal R. F.), Endalamaw, A. (Aklilu), Endalew, D. A. (Daniel Adane), Eskandarieh, S. (Sharareh), Esteghamati, A. (Alireza), Esteghamati, S. (Sadaf), Etemadi, A. (Arash), Ezekannagha, O. (Oluchi), Fareed, M. (Mohammad), Faridnia, R. (Roghiyeh), Farzadfar, F. (Farshad), Fazlzadeh, M. (Mehdi), Feigin, V. L. (Valery L.), Fereshtehnejad, S.-M. (Seyed-Mohammad), Fernandes, E. (Eduarda), Filip, I. (Irina), Fischer, F. (Florian), Foigt, N. A. (Nataliya A.), Folayan, M. O. (Morenike Oluwatoyin), Foroutan, M. (Masoud), Franklin, R. C. (Richard Charles), Fukumoto, T. (Takeshi), Gad, M. M. (Mohamed M.), Gayesa, R. T. (Reta Tsegaye), Gebre, T. (Teshome), Gebremedhin, K. B. (Ketema Bizuwork), Gebremeskel, G. G. (Gebreamlak Gebremedhn), Gesesew, H. A. (Hailay Abrha), Gezae, K. E. (Kebede Embaye), Ghadiri, K. (Keyghobad), Ghashghaee, A. (Ahmad), Ghimire, P. R. (Pramesh Raj), Gill, P. S. (Paramjit Singh), Gill, T. K. (Tiffany K.), Ginindza, T. G. (Themba G.), Gomes, N. G. (Nelson G. M.), Gopalani, S. V. (Sameer Vali), Goulart, A. C. (Alessandra C.), Goulart, B. N. (Barbara Niegia Garcia), Grada, A. (Ayman), Gubari, M. I. (Mohammed Ibrahim Mohialdeen), Gugnani, H. C. (Harish Chander), Guido, D. (Davide), Guimaraes, R. A. (Rafael Alves), Guo, Y. (Yuming), Gupta, R. (Rajeev), Hafezi-Nejad, N. (Nima), Haile, D. H. (Dessalegn H.), Hailu, G. B. (Gessessew Bugssa), Haj-Mirzaian, A. (Arvin), Haj-Mirzaian, A. (Arya), Hamadeh, R. R. (Randah R.), Hamidi, S. (Samer), Handiso, D. W. (Demelash Woldeyohannes), Haririan, H. (Hamidreza), Hariyani, N. (Ninuk), Hasaballah, A. I. (Ahmed I.), Hasan, M. M. (Md Mehedi), Hasanpoor, E. (Edris), Hasanzadeh, A. (Amir), Hassankhani, H. (Hadi), Hassen, H. Y. (Hamid Yimam), Hegazy, M. I. (Mohamed I.), Heibati, B. (Behzad), Heidari, B. (Behnam), Hendrie, D. (Delia), Henry, N. J. (Nathaniel J.), Herteliu, C. (Claudiu), Heydarpour, F. (Fatemeh), de Hidru, H. D. (Hagos Degefa), Hird, T. R. (Thomas R.), Hoang, C. L. (Chi Linh), Rad, E. H. (Enayatollah Homaie), Hoogar, P. (Praveen), Hoseini, M. (Mohammad), Hossain, N. (Naznin), Hosseini, M. (Mostafa), Hosseinzadeh, M. (Mehdi), Househ, M. (Mowafa), Hsairi, M. (Mohamed), Hu, G. (Guoqing), Hussen, M. M. (Mohammedaman Mama), Ibitoye, S. E. (Segun Emmanuel), Igumbor, E. U. (Ehimario U.), Ilesanmi, O. S. (Olayinka Stephen), Ilic, M. D. (Milena D.), Imani-Nasab, M. H. (Mohammad Hasan), Iqbal, U. (Usman), Irvani, S. S. (Seyed Sina Naghibi), Islam, S. M. (Sheikh Mohammed Shariful), Iwu, C. J. (Chinwe Juliana), Izadi, N. (Neda), Jaca, A. (Anelisa), Jahanmehr, N. (Nader), Jakovljevic, M. (Mihajlo), Jalali, A. (Amir), Jayatilleke, A. U. (Achala Upendra), Jha, R. P. (Ravi Prakash), Jha, V. (Vivekanand), Ji, J. S. (John S.), Jonas, J. B. (Jost B.), Jozwiak, J. J. (Jacek Jerzy), Kabir, A. (Ali), Kabir, Z. (Zubair), Kahsay, A. (Amaha), Kalani, H. (Hamed), Kanchan, T. (Tanuj), Matin, B. K. (Behzad Karami), Karch, A. (Andre), Karim, M. A. (Mohd Anisul), Karki, H. K. (Hamidreza Karimi-Sari Surendra), Kasaeian, A. (Amir), Kasahun, G. G. (Gebremicheal Gebreslassie), Kasahun, Y. C. (Yawukal Chane), Kasaye, H. K. (Habtamu Kebebe), Kassa, G. G. (Gebrehiwot G.), Kassa, G. M. (Getachew Mullu), Kayode, G. A. (Gbenga A.), Karyani, A. K. (Ali Kazemi), Kebede, M. M. (Mihiretu M.), Keiyoro, P. N. (Peter Njenga), Kelbore, A. G. (Abraham Getachew), Kengne, A. P. (Andre Pascal), Ketema, D. B. (Daniel Bekele), Khader, Y. S. (Yousef Saleh), Khafaie, M. A. (Morteza Abdullatif), Khalid, N. (Nauman), Khalilov, R. (Rovshan), Khan, E. A. (Ejaz Ahmad), Khan, J. (Junaid), Khan, M. N. (Md Nuruzzaman), Khan, M. S. (Muhammad Shahzeb), Khatab, K. (Khaled), Khater, A. M. (Amir M.), Khater, M. M. (Mona M.), Khayamzadeh, M. (Maryam), Khazaei, M. (Mohammad), Khazaei, S. (Salman), Khosravi, M. H. (Mohammad Hossein), Khubchandani, J. (Jagdish), Kiadaliri, A. (Ali), Kim, Y. J. (Yun Jin), Kimokoti, R. W. (Ruth W.), Kisa, A. (Adnan), Kisa, S. (Sezer), Kissoon, N. (Niranjan), Shivakumar, K. M. (K. M.), Kochhar, S. (Sonali), Kolola, T. (Tufa), Komaki, H. (Hamidreza), Kosen, S. (Soewarta), Koul, P. A. (Parvaiz A.), Koyanagi, A. (Ai), Kraemer, M. U. (Moritz U. G.), Krishan, K. (Kewal), Kugbey, N. (Nuworza), Kumar, G. A. (G. Anil), Kumar, M. (Manasi), Kumar, P. (Pushpendra), Kusuma, V. K. (Vivek Kumar Dian), La Vecchia, C. (Carlo), Lacey, B. (Ben), Lad, S. D. (Sheetal D.), Lal, D. K. (Dharmesh Kumar), Lam, F. (Felix), Lami, F. H. (Faris Hasan), Lamichhane, P. (Prabhat), Lansingh, V. C. (Van Charles), Lasrado, S. (Savita), Laxmaiah, A. (Avula), Lee, P. H. (Paul H.), LeGrand, K. E. (Kate E.), Leili, M. (Mostafa), Lenjebo, T. L. (Tsegaye Lolaso), Leshargie, C. T. (Cheru Tesema), Levine, A. J. (Aubrey J.), Li, S. (Shanshan), Linn, S. (Shai), Liu, S. (Shiwei), Liu, S. (Simin), Lodha, R. (Rakesh), Longbottom, J. (Joshua), Lopez, J. C. (Jaifred Christian F.), Abd El Razek, H. M. (Hassan Magdy), Abd El Razek, M. M. (Muhammed Magdy), Prasad, D. R. (D. R. Mahadeshwara), Mahasha, P. W. (Phetole Walter), Mahotra, N. B. (Narayan B.), Majeed, A. (Azeem), Malekzadeh, R. (Reza), Malta, D. C. (Deborah Carvalho), Mamun, A. A. (Abdullah A.), Manafi, N. (Navid), Manda, A. L. (Ana Laura), Manohar, N. D. (Narendar Dawani Dawanu), Mansournia, M. A. (Mohammad Ali), Mapoma, C. C. (Chabila Christopher), Maravilla, J. C. (Joemer C.), Martinez, G. (Gabriel), Martini, S. (Santi), Martins-Melo, F. R. (Francisco Rogerlandio), Masaka, A. (Anthony), Massenburg, B. B. (Benjamin Ballard), Mathur, M. R. (Manu Raj), Mayala, B. K. (Benjamin K.), Mazidi, M. (Mohsen), McAlinden, C. (Colm), Meharie, B. G. (Birhanu Geta), Mehndiratta, M. M. (Man Mohan), Mehta, K. M. (Kala M.), Mekonnen, T. C. (Tefera Chane), Meles, G. G. (Gebrekiros Gebremichael), Memiah, P. T. (Peter T. N.), Memish, Z. A. (Ziad A.), Mendoza, W. (Walter), Menezes, R. G. (Ritesh G.), Mereta, S. T. (Seid Tiku), Meretoja, T. J. (Tuomo J.), Mestrovic, T. (Tomislav), Miazgowski, B. (Bartosz), Mihretie, K. M. (Kebadnew Mulatu), Miller, T. R. (Ted R.), Mini, G. K. (G. K.), Mirrakhimov, E. M. (Erkin M.), Moazen, B. (Babak), Mohajer, B. (Bahram), Mohamadi-Bolbanabad, A. (Amjad), Mohammad, D. K. (Dara K.), Mohammad, K. A. (Karzan Abdulmuhsin), Mohammad, Y. (Yousef), Mezerji, N. M. (Naser Mohammad Gholi), Mohammadibakhsh, R. (Roghayeh), Mohammadifard, N. (Noushin), Mohammed, J. A. (Jemal Abdu), Mohammed, S. (Shafiu), Mohebi, F. (Farnam), Mokdad, A. H. (Ali H.), Molokhia, M. (Mariam), Monasta, L. (Lorenzo), Moodley, Y. (Yoshan), Moore, C. E. (Catrin E.), Moradi, G. (Ghobad), Moradi, M. (Masoud), Moradi-Joo, M. (Mohammad), Moradi-Lakeh, M. (Maziar), Moraga, P. (Paula), Morales, L. (Linda), Velasquez, I. M. (Ilais Moreno), Mosapour, A. (Abbas), Mouodi, S. (Simin), Mousavi, S. M. (Seyyed Meysam), Mozaffor, M. (Miliva), Muchie, K. F. (Kindie Fentahun), Mulaw, G. F. (Getahun Fentaw), Munro, S. B. (Sandra B.), Muriithi, M. K. (Moses K.), Murray, C. J. (Christoper J. L.), Murthy, G. V. (G. V. S.), Musa, K. I. (Kamarul Imran), Mustafa, G. (Ghulam), Muthupandian, S. (Saravanan), Nabhan, A. F. (Ashraf F.), Naderi, M. (Mehdi), Nagarajan, A. J. (Ahamarshan Jayaraman), Naidoo, K. S. (Kovin S.), Naik, G. (Gurudatta), Najafi, F. (Farid), Nangia, V. (Vinay), Nansseu, J. R. (Jobert Richie), Nascimento, B. R. (Bruno Ramos), Nazari, J. (Javad), Ndwandwe, D. E. (Duduzile Edith), Negoi, I. (Ionut), Netsere, H. B. (Henok Biresaw), Ngunjiri, J. W. (Josephine W.), Nguyen, C. T. (Cuong Tat), Nguyen, H. L. (Huong Lan Thi), Nguyen, T. H. (Trang Huyen), Nigatu, D. (Dabere), Nigatu, S. G. (Solomon Gedlu), Ningrum, D. N. (Dina Nur Anggraini), Nnaji, C. A. (Chukwudi A.), Nojomi, M. (Marzieh), Nong, V. M. (Vuong Minh), Norheim, O. F. (Ole F.), Noubiap, J. J. (Jean Jacques), Motlagh, S. N. (Soraya Nouraei), Oancea, B. (Bogdan), Ogah, O. S. (Okechukwu Samuel), Ogbo, F. A. (Felix Akpojene), Oh, I.-H. (In-Hwan), Olagunju, A. T. (Andrew T.), Olagunju, T. O. (Tinuke O.), Olusanya, B. O. (Bolajoko Olubukunola), Olusanya, J. O. (Jacob Olusegun), Onwujekwe, O. E. (Obinna E.), Oren, E. (Eyal), Ortega-Altamirano, D. V. (Doris V.), Osarenotor, O. (Osayomwanbo), Osei, F. B. (Frank B.), Owolabi, M. O. (Mayowa O.), Mahesh, P. A. (P. A.), Padubidri, J. R. (Jagadish Rao), Pakhale, S. (Smita), Patel, S. K. (Sangram Kishor), Paternina-Caicedo, A. J. (Angel J.), Pathak, A. (Ashish), Patton, G. C. (George C.), Paudel, D. (Deepak), Paulos, K. (Kebreab), Pepito, V. C. (Veincent Christian Filipino), Pereira, A. (Alexandre), Perico, N. (Norberto), Pervaiz, A. (Aslam), Pescarini, J. M. (Julia Moreira), Piroozi, B. (Bakhtiar), Pirsaheb, M. (Meghdad), Postma, M. J. (Maarten J.), Pourjafar, H. (Hadi), Pourmalek, F. (Farshad), Pourshams, A. (Akram), Poustchi, H. (Hossein), Prada, S. I. (Sergio I.), Prasad, N. (Narayan), Preotescu, L. (Liliana), Quintana, H. (Hedley), Rabiee, N. (Navid), Radfar, A. (Amir), Rafiei, A. (Alireza), Rahim, F. (Fakher), Rahimi-Movaghar, A. (Afarin), Rahimi-Movaghar, V. (Vafa), Rahman, M. H. (Mohammad Hifz Ur), Rahman, M. A. (Muhammad Aziz), Rahman, S. (Shafiur), Rajati, F. (Fatemeh), Rana, S. M. (Saleem Muhammad), Ranabhat, C. L. (Chhabi Lal), Rasella, D. (Davide), Rawaf, D. L. (David Laith), Rawaf, S. (Salman), Rawal, L. (Lal), Rawasia, W. F. (Wasiq Faraz), Renjith, V. (Vishnu), Renzaho, A. M. (Andre M. N.), Resnikoff, S. (Serge), Reta, M. A. (Melese Abate), Rezaei, N. (Negar), Rezai, M. S. (Mohammad Sadegh), Riahi, S. M. (Seyed Mohammad), Ribeiro, A. I. (Ana Isabel), Rickard, J. (Jennifer), Rios-Blancas, M. (Maria), Roever, L. (Leonardo), Ronfani, L. (Luca), Roro, E. M. (Elias Merdassa), Ross, J. M. (Jennifer M.), Rubagotti, E. (Enrico), Rubino, S. (Salvatore), Saad, A. M. (Anas M.), Sabde, Y. D. (Yogesh Damodar), Sabour, S. (Siamak), Sadeghi, E. (Ehsan), Safari, Y. (Yahya), Safari-Faramani, R. (Roya), Sagar, R. (Rajesh), Sahebkar, A. (Amirhossein), Sahraian, M. A. (Mohammad Ali), Sajadi, S. M. (S. Mohammad), Salahshoor, M. R. (Mohammad Reza), Salam, N. (Nasir), Salamati, P. (Payman), Salem, H. (Hosni), Salem, M. R. (Marwa Rashad), Salimi, Y. (Yahya), Salimzadeh, H. (Hamideh), Samy, A. M. (Abdallah M.), Sanabria, J. (Juan), Santric-Milicevic, M. M. (Milena M.), Jose, B. P. (Bruno Piassi Sao), Saraswathy, S. Y. (Sivan Yegnanarayana Iyer), Sarkar, K. (Kaushik), Sarker, A. R. (Abdur Razzaque), Sarrafzadegan, N. (Nizal), Sartorius, B. (Benn), Sathian, B. (Brijesh), Sathish, T. (Thirunavukkarasu), Sawhney, M. (Monika), Saxena, S. (Sonia), Schwebel, D. C. (David C.), Senbeta, A. M. (Anbissa Muleta), Senthilkumaran, S. (Subramanian), Sepanlou, S. G. (Sadaf G.), Servan-Mori, E. (Edson), Shabaninejad, H. (Hosein), Shafieesabet, A. (Azadeh), Shaikh, M. A. (Masood Ali), Shalash, A. S. (Ali S.), Shallo, S. A. (Seifadin Ahmed), Shams-Beyranvand, M. (Mehran), Shamsi, M. (MohammadBagher), Shamsizadeh, M. (Morteza), Shannawaz, M. (Mohammed), Sharafi, K. (Kiomars), Sharifi, H. (Hamid), Shehata, H. S. (Hatem Samir), Sheikh, A. (Aziz), Shetty, B. S. (B. Suresh Kumar), Shibuya, K. (Kenji), Shiferaw, W. S. (Wondimeneh Shibabaw), Shifti, D. M. (Desalegn Markos), Shigematsu, M. (Mika), Il Shin, J. (Jae), Shiri, R. (Rahman), Shirkoohi, R. (Reza), Siabani, S. (Soraya), Siddiqi, T. J. (Tariq Jamal), Silva, D. A. (Diego Augusto Santos), Singh, A. (Ambrish), Singh, J. A. (Jasvinder A.), Singh, N. P. (Narinder Pal), Singh, V. (Virendra), Sisay, M. M. (Malede Mequanent), Skiadaresi, E. (Eirini), Sobhiyeh, M. R. (Mohammad Reza), Sokhan, A. (Anton), Soltani, S. (Shahin), Somayaji, R. (Ranjani), Soofi, M. (Moslem), Sorrie, M. B. (Muluken Bekele), Soyiri, I. N. (Ireneous N.), Sreeramareddy, C. T. (Chandrashekhar T.), Sudaryanto, A. (Agus), Sufiyan, M. B. (Mu'awiyyah Babale), Suleria, H. A. (Hafiz Ansar Rasul), Sultana, M. (Marufa), Sunguya, B. F. (Bruno Fokas), Sykes, B. L. (Bryan L.), Tabares-Seisdedos, R. (Rafael), Tabuchi, T. (Takahiro), Tadesse, D. B. (Degena Bahrey), Tarigan, I. U. (Ingan Ukur), Tasew, A. A. (Aberash Abay), Tefera, Y. M. (Yonatal Mesfin), Tekle, M. G. (Merhawi Gebremedhin), Temsah, M.-H. (Mohamad-Hani), Tesfay, B. E. (Berhe Etsay), Tesfay, F. H. (Fisaha Haile), Tessema, B. (Belay), Tessema, Z. T. (Zemenu Tadesse), Thankappan, K. R. (Kavumpurathu Raman), Thomas, N. (Nihal), Toma, A. (Alemayehu), Topor-Madry, R. (Roman), Tovani-Palone, M. R. (Marcos Roberto), Traini, E. (Eugenio), Tran, B. X. (Bach Xuan), Tran, K. B. (Khanh Bao), Ullah, I. (Irfan), Unnikrishnan, B. (Bhaskaran), Usman, M. S. (Muhammad Shariq), Uzochukwu, B. S. (Benjamin S. Chudi), Valdez, P. R. (Pascual R.), Varughese, S. (Santosh), Violante, F. S. (Francesco S.), Vollmer, S. (Sebastian), Hawariat, F. G. (Feleke Gebremeskel W.), Waheed, Y. (Yasir), Wallin, M. T. (Mitchell Taylor), Wang, Y. (Yafeng), Wang, Y.-P. (Yuan-Pang), Weaver, M. (Marcia), Weji, B. G. (Bedilu Girma), Weldesamuel, G. T. (Girmay Teklay), Welgan, C. A. (Catherine A.), Werdecker, A. (Andrea), Westerman, R. (Ronny), Wiangkham, T. (Taweewat), Wiysonge, C. S. (Charles Shey), Wolde, H. F. (Haileab Fekadu), Wondafrash, D. Z. (Dawit Zewdu), Wonde, T. E. (Tewodros Eshete), Worku, G. T. (Getasew Taddesse), Wu, A.-M. (Ai-Min), Xu, G. (Gelin), Yadollahpour, A. (Ali), Jabbari, S. H. (Seyed Hossein Yahyazadeh), Yamada, T. (Tomohide), Yatsuya, H. (Hiroshi), Yeshaneh, A. (Alex), Yilgwan, C. S. (Christopher Sabo), Yilma, M. T. (Mekdes Tigistu), Yip, P. (Paul), Yisma, E. (Engida), Yonemoto, N. (Naohiro), Yoon, S.-J. (Seok-Jun), Younis, M. Z. (Mustafa Z.), Yousefifard, M. (Mahmoud), Yousof, H. S. (Hebat-Allah Salah A.), Yu, C. (Chuanhua), Yusefzadeh, H. (Hasan), Zadey, S. (Siddhesh), Zaidi, Z. (Zoubida), Bin Zaman, S. (Sojib), Zamani, M. (Mohammad), Zandian, H. (Hamed), Zepro, N. B. (Nejimu Biza), Zerfu, T. A. (Taddese Alemu), Zhang, Y. (Yunquan), Zhao, X. G. (Xiu-Ju George), Ziapour, A. (Arash), Zodpey, S. (Sanjay), Zuniga, Y. M. (Yves Miel H.), Hay, S. I. (Simon I.), and Reiner, R. C. (Robert C., Jr.)

Abstract

Background: Oral rehydration solution (ORS) is a form of oral rehydration therapy (ORT) for diarrhoea that has the potential to drastically reduce child mortality; yet, according to UNICEF estimates, less than half of children younger than 5 years with diarrhoea in low-income and middle-income countries (LMICs) received ORS in 2016. A variety of recommended home fluids (RHF) exist as alternative forms of ORT; however, it is unclear whether RHF prevent child mortality. Previous studies have shown considerable variation between countries in ORS and RHF use, but subnational variation is unknown. This study aims to produce high-resolution geospatial estimates of relative and absolute coverage of ORS, RHF, and ORT (use of either ORS or RHF) in LMICs. Methods: We used a Bayesian geostatistical model including 15 spatial covariates and data from 385 household surveys across 94 LMICs to estimate annual proportions of children younger than 5 years of age with diarrhoea who received ORS or RHF (or both) on continuous continent-wide surfaces in 2000–17, and aggregated results to policy-relevant administrative units. Additionally, we analysed geographical inequality in coverage across administrative units and estimated the number of diarrhoeal deaths averted by increased coverage over the study period. Uncertainty in the mean coverage estimates was calculated by taking 250 draws from the posterior joint distribution of the model and creating uncertainty intervals (UIs) with the 2·5th and 97·5th percentiles of those 250 draws. Findings: While ORS use among children with diarrhoea increased in some countries from 2000 to 2017, coverage remained below 50% in the majority (62·6%; 12 417 of 19 823) of second administrative-level units and an estimated 6 519 000 children (95% UI 5 254 000–7 733 000) with diarrhoea were not treated with any form of ORT in 2017. Increases in ORS use corresponded with declines in RHF in many locations, resulting in relatively constant overall O

Published
2020

27. Global, regional, and national incidence, prevalence, and mortality of HIV, 1980-2017, and forecasts to 2030, for 195 countries and territories: A systematic analysis for the Global Burden of Diseases, Injuries, and Risk Factors Study 2017

Author

Frank, T.D. Carter, A. Jahagirdar, D. Biehl, M.H. Douwes-Schultz, D. Larson, S.L. Arora, M. Dwyer-Lindgren, L. Steuben, K.M. Abbastabar, H. Abu-Raddad, L.J. Abyu, D.M. Adabi, M. Adebayo, O.M. Adekanmbi, V. Adetokunboh, O.O. Ahmadi, A. Ahmadi, K. Ahmadian, E. Ahmadpour, E. Ahmed, M.B. Akal, C.G. Alahdab, F. Alam, N. Albertson, S.B. Alemnew, B.T.T. Alene, K.A. Alipour, V. Alvis-Guzman, N. Amini, S. Anbari, Z. Anber, N.H. Anjomshoa, M. Antonio, C.A.T. Arabloo, J. Aremu, O. Areri, H.A. Asfaw, E.T. Ashagre, A.F. Asmelash, D. Asrat, A.A. Avokpaho, E.F.G.A. Awasthi, A. Awoke, N. Ayanore, M.A. Azari, S. Badawi, A. Bagherzadeh, M. Banach, M. Barac, A. Bärnighausen, T.W. Basu, S. Bedi, N. Behzadifar, M. Bekele, B.B. Belay, S.A. Belay, Y.B. Belayneh, Y.M.M. Berhane, A. Bhat, A.G. Bhattacharyya, K. Biadgo, B. Bijani, A. Shahdaat Bin Sayeed, M. Bitew, H. Blinov, A. Bogale, K.A. Bojia, H.A. Burugina Nagaraja, S.B.N. Butt, Z.A. Cahuana-Hurtado, L. Campuzano Rincon, J.C. Carvalho, F. Chattu, V.K. Christopher, D.J. Chu, D.-T. Crider, R. Dahiru, T. Dandona, L. Dandona, R. Daryani, A. Das Neves, J. De Neve, J.-W. Degenhardt, L. Demeke, F.M. Demis, A.B.B. Demissie, D.B. Demoz, G.T. Deribe, K. Des Jarlais, D. Dhungana, G.P. Diaz, D. Djalalinia, S. Do, H.P. Doan, L.P. Duber, H. Dubey, M. Dubljanin, E. Duken, E.E. Duko Adema, B. Effiong, A. Eftekhari, A. El Sayed Zaki, M. El-Jaafary, S.I. El-Khatib, Z. Elsharkawy, A. Endries, A.Y. Eskandarieh, S. Eyawo, O. Farzadfar, F. Fatima, B. Fentahun, N. Fernandes, E. Filip, I. Fischer, F. Folayan, M.O. Foroutan, M. Fukumoto, T. Fullman, N. Garcia-Basteiro, A.L. Gayesa, R.T. Gebremedhin, K.B. Gebremeskel, G.G. Gebreyohannes, K.K. Gedefaw, G.A. Gelaw, B.K. Gesesew, H.A. Geta, B. Gezae, K.E. Ghadiri, K. Ghashghaee, A. Ginindza, T.T.G. Gugnani, H.C. Guimarães, R.A. Haile, M.T. Hailu, G.B. Haj-Mirzaian, A. Haj-Mirzaian, A. Hamidi, S. Handanagic, S. Handiso, D.W. Hanfore, L.K. Hasanzadeh, A. Hassankhani, H. Hassen, H.Y. Hay, S.I. Henok, A. Hoang, C.L. Hosgood, H.D. Hosseinzadeh, M. Hsairi, M. Ibitoye, S.E. Idrisov, B. Ikuta, K.S. Ilesanmi, O.S. Irvani, S.S.N. Iwu, C.J. Jacobsen, K.H. James, S.L. Jenabi, E. Jha, R.P. Jonas, J.B. Jorjoran Shushtari, Z. Kabir, A. Kabir, Z. Kadel, R. Kasaeian, A. Kassa, B. Kassa, G.M. Kassa, T.D. Kayode, G.A. Kebede, M.M. Kefale, A.T. Kengne, A.P. Khader, Y.S. Khafaie, M.A. Khalid, N. Khan, E.A. Khan, G. Khan, J. Khang, Y.-H. Khatab, K. Khazaei, S. Khoja, A.T. Kiadaliri, A.A. Kim, Y.J. Kisa, A. Kisa, S. Kochhar, S. Komaki, H. Koul, P.A. Koyanagi, A. Kuate Defo, B. Kumar, G.A. Kumar, M. Kuupiel, D. Lal, D.K. Lee, J.J.-H. Lenjebo, T.L. Leshargie, C.T. Macarayan, E.R.K. Maddison, E.R. Magdy Abd El Razek, H. Magis-Rodriguez, C. Mahasha, P.W. Majdan, M. Majeed, A. Malekzadeh, R. Manafi, N. Mapoma, C.C. Martins-Melo, F.R. Masaka, A. Mayenga, E.N.L. Mehta, V. Meles, G.G. Meles, H.G. Melese, A. Melku, M. Memiah, P.T.N. Memish, Z.A. Mena, A.T. Mendoza, W. Mengistu, D.T. Mengistu, G. Meretoja, T.J. Mestrovic, T. Miller, T.R. Moazen, B. Mohajer, B. Mohamadi-Bolbanabad, A. Mohammad, K.A. Mohammad, Y. Mohammad Darwesh, A. Mohammad Gholi Mezerji, N. Mohammadi, M. Mohammadibakhsh, R. Mohammadoo-Khorasani, M. Mohammed, J.A. Mohammed, S. Mohebi, F. Mokdad, A.H. Moodley, Y. Moossavi, M. Moradi, G. Moradi-Lakeh, M. Moschos, M.M. Mossie, T.B. Mousavi, S.M. Muchie, K.F. Muluneh, A.G. Muriithi, M.K. Mustafa, G. Muthupandian, S. Nagarajan, A.J. Naik, G. Najafi, F. Nazari, J. Ndwandwe, D.E. Nguyen, C.T. Nguyen, H.L.T. Nguyen, S.H. Nguyen, T.H. Ningrum, D.N.A. Nixon, M.R. Nnaji, C.A. Noroozi, M. Noubiap, J.J. Nourollahpour Shiadeh, M. Obsa, M.S. Odame, E.A. Ofori-Asenso, R. Ogbo, F.A. Okoro, A. Oladimeji, O. Olagunju, A.T. Olagunju, T.O. Olum, S. Oppong Asante, K. Oren, E. Otstavnov, S.S. Mahesh, P.A. Padubidri, J.R. Pakhale, S. Pakpour, A.H. Patel, S.K. Paulos, K. Pepito, V.C.F. Peprah, E.K. Piroozi, B. Pourshams, A. Qorbani, M. Rabiee, M. Rabiee, N. Radfar, A. Rafay, A. Rafiei, A. Rahim, F. Rahimi-Movaghar, A. Rahimi-Movaghar, V. Rahman, S.U. Ranabhat, C.L. Rawaf, S. Reis, C. Renjith, V. Reta, M.A. Rezai, M.S. Rios González, C.M. Merdassa Roro, E.E.M. Rostami, A. Rubino, S. Saeedi Moghaddam, S. Safari, S. Sagar, R. Sahraian, M.A. Salem, M.R.R. Salimi, Y. Salomon, J.A. Sambala, E.Z. Samy, A.M. Sartorius, B. Satpathy, M. Sawhney, M. Sayyah, M. Schutte, A.E. Sepanlou, S.G. Seyedmousavi, S. Shabaninejad, H. Shaheen, A.A. Shaikh, M.A. Shallo, S.A. Shamsizadeh, M. Sharifi, H. Shibuya, K. Shin, J.I. Shirkoohi, R. Silva, D.A.S. Silveira, D.G.A. Singh, J.A. Sisay, M.M.M. Sisay, M. Sisay, S. Smith, A.E. Sokhan, A. Somayaji, R. Soshnikov, S. Stein, D.J. Sufiyan, M.B. Sunguya, B.F. Sykes, B.L. Tadesse, B.T. Tadesse, D.B. Tamirat, K.S. Taveira, N. Tekelemedhin, S.W. Temesgen, H.D. Tesfay, F.H. Teshale, M.Y. Thapa, S. Tlaye, K.G. Topp, S.M. Tovani-Palone, M.R. Tran, B.X. Tran, K.B. Ullah, I. Unnikrishnan, B. Uthman, O.A. Veisani, Y. Vladimirov, S.K. Wada, F.W. Waheed, Y. Weldegwergs, K.G. Weldesamuel, G.T.T. Westerman, R. Wijeratne, T. Wolde, H.F. Wondafrash, D.Z. Wonde, T.E. Wondmagegn, B.Y. Yeshanew, A.G. Yilma, M.T. Yimer, E.M. Yonemoto, N. Yotebieng, M. Youm, Y. Yu, C. Zaidi, Z. Zarghi, A. Zenebe, Z.M. Zewale, T.A. Ziapour, A. Zodpey, S. Naghavi, M. Vollset, S.E. Wang, H. Lim, S.S. Kyu, H.H. Murray, C.J.L. GBD 2017 HIV collaborators

Abstract

Background Understanding the patterns of HIV/AIDS epidemics is crucial to tracking and monitoring the progress of prevention and control efforts in countries. We provide a comprehensive assessment of the levels and trends of HIV/AIDS incidence, prevalence, mortality, and coverage of antiretroviral therapy (ART) for 1980-2017 and forecast these estimates to 2030 for 195 countries and territories. Methods We determined a modelling strategy for each country on the basis of the availability and quality of data. For countries and territories with data from population-based seroprevalence surveys or antenatal care clinics, we estimated prevalence and incidence using an open-source version of the Estimation and Projection Package - a natural history model originally developed by the UNAIDS Reference Group on Estimates, Modelling, and Projections. For countries with cause-specific vital registration data, we corrected data for garbage coding (ie, deaths coded to an intermediate, immediate, or poorly defined cause) and HIV misclassification. We developed a process of cohort incidence bias adjustment to use information on survival and deaths recorded in vital registration to back-calculate HIV incidence. For countries without any representative data on HIV, we produced incidence estimates by pulling information from observed bias in the geographical region. We used a re-coded version of the Spectrum model (a cohort component model that uses rates of disease progression and HIV mortality on and off ART) to produce agesex- specific incidence, prevalence, and mortality, and treatment coverage results for all countries, and forecast these measures to 2030 using Spectrum with inputs that were extended on the basis of past trends in treatment scale-up and new infections. Findings Global HIV mortality peaked in 2006 with 1·95 million deaths (95% uncertainty interval 1·87-2·04) and has since decreased to 0·95 million deaths (0·91-1·01) in 2017. New cases of HIV globally peaked in 1999 (3·16 million, 2·79-3·67) and since then have gradually decreased to 1·94 million (1·63-2·29) in 2017. These trends, along with ART scale-up, have globally resulted in increased prevalence, with 36·8 million (34·8-39·2) people living with HIV in 2017. Prevalence of HIV was highest in southern sub-Saharan Africa in 2017, and countries in the region had ART coverage ranging from 65·7% in Lesotho to 85·7% in eSwatini. Our forecasts showed that 54 countries will meet the UNAIDS target of 81% ART coverage by 2020 and 12 countries are on track to meet 90% ART coverage by 2030. Forecasted results estimate that few countries will meet the UNAIDS 2020 and 2030 mortality and incidence targets. Interpretation Despite progress in reducing HIV-related mortality over the past decade, slow decreases in incidence, combined with the current context of stagnated funding for related interventions, mean that many countries are not on track to reach the 2020 and 2030 global targets for reduction in incidence and mortality. With a growing population of people living with HIV, it will continue to be a major threat to public health for years to come. The pace of progress needs to be hastened by continuing to expand access to ART and increasing investments in proven HIV prevention initiatives that can be scaled up to have population-level impact. © 2019 The Author(s).

Published
2019

28. Mortality, morbidity, and hospitalisations due to influenza lower respiratory tract infections, 2017: an analysis for the Global Burden of Disease Study 2017

Author

Troeger C, Blacker B, Khalil I, Zimsen S, Albertson S, Abate D, Abdela J, Adhikari T, Aghayan S, Agrawal S, Ahmadi A, Aichour A, Aichour I, Aichour M, Al-Eyadhy A, Al-Raddadi R, Alahdab F, Alene K, Aljunid S, Alvis-Guzman N, Anber N, Anjomshoa M, Antonio C, Aremu O, Atalay H, Atique S, Attia E, Avokpaho E, Awasthi A, Babazadeh A, Badali H, Badawi A, Banoub J, Barac A, Bassat Q, Bedi N, Belachew A, Bennett D, Bhattacharyya K, Bhutta Z, Bijani A, Carvalho F, Castaneda-Orjuela C, Christopher D, Dandona L, Dandona R, Dang A, Daryani A, Degefa M, Demeke F, Dhimal M, Djalalinia S, Doku D, Dubey M, Dubljanin E, Duken E, Edessa D, Zaki M, Fakhim H, Fernandes E, Fischer F, Flor L, Foreman K, Gebremichael T, Geremew D, Ghadiri K, Goulart A, Guo J, Ha G, Hailu G, Haj-Mirzaian A, Hamidi S, Hassen H, Hoang C, Horita N, Hostiuc M, Irvani S, Jha R, Jonas J, Kahsay A, Karch A, Kasaeian A, Kassa T, Kefale A, Khader Y, Khan E, Khan G, Khan M, Khang Y, Khoja A, Khubchandani J, Kimokoti R, Kisa A, Knibbs L, Kochhar S, Kosen S, Koul P, Koyanagi A, Defo B, Kumar G, Lal D, Lamichhane P, Leshargie C, Levi M, Li S, Macarayan E, Majdan M, Mehta V, Melese A, Memish Z, Mengistu D, Meretoja T, Mestrovic T, Miazgowski B, Milne G, Milosevic B, Mirrakhimov E, Moazen B, Mohammad K, Mohammed S, Monasta L, Morawska L, Mousavi S, Muhammed O, Murthy S, Mustafa G, Naheed A, Nguyen H, Nguyen N, Nguyen S, Nguyen T, Nisar M, Nixon M, Ogbo F, Olagunju A, Olagunju T, Oren E, Ortiz J, Mahesh P, Pakhale S, Patel S, Paudel D, Pigott D, Postma M, Qorbani M, Rafay A, Rafiei A, Rahimi-Movaghar V, Rai R, Rezai M, Roberts N, Ronfani L, Rubino S, Safari S, Safiri S, Saleem Z, Sambala E, Samy A, Milicevic M, Sartorius B, Sarvi S, Savic M, Sawhney M, Saxena S, Seyedmousavi S, Shaikh M, Sharif M, Sheikh A, Shigematsu M, Smith D, Somayaji R, Soriano J, Sreeramareddy C, Sufiyan M, Temsah M, Tessema B, Teweldemedhin M, Tortajada-Girbes M, Tran B, Tran K, Tsadik A, Ukwaja K, Ullah I, Vasankari T, Vollset S, Vu G, Wada F, Waheed Y, West T, Wiysonge C, Yimer E, Yonemoto N, Zaidi Z, Vos T, Lim S, Murray C, Mokdad A, Hay S, Reiner R, and GBD 2017 Influenza Collaborators

Subjects
PNEUMONIA, AFRICA, Adult, Male, BACTERIAL, Internationality, Adolescent, Respiratory System, CHILDREN, Global Health, Global Burden of Disease, 1117 Public Health and Health Services, Young Adult, Age Distribution, Critical Care Medicine, Risk Factors, General & Internal Medicine, VACCINES, Influenza, Human, GBD 2017 Influenza Collaborators, Humans, Child, Respiratory Tract Infections, Aged, Aged, 80 and over, Science & Technology, Incidence, Infant, 1103 Clinical Sciences, Length of Stay, Middle Aged, Hospitalization, Child, Preschool, VACCINATION, Female, Life Sciences & Biomedicine, 1199 Other Medical and Health Sciences
Abstract

Background Although the burden of influenza is often discussed in the context of historical pandemics and the threat of future pandemics, every year a substantial burden of lower respiratory tract infections (LRTIs) and other respiratory conditions (like chronic obstructive pulmonary disease) are attributable to seasonal influenza. The Global Burden of Disease Study (GBD) 2017 is a systematic scientific effort to quantify the health loss associated with a comprehensive set of diseases and disabilities. In this Article, we focus on LRTIs that can be attributed to influenza. Methods We modelled the LRTI incidence, hospitalisations, and mortality attributable to influenza for every country and selected subnational locations by age and year from 1990 to 2017 as part of GBD 2017. We used a counterfactual approach that first estimated the LRTI incidence, hospitalisations, and mortality and then attributed a fraction of those outcomes to influenza. Findings Influenza LRTI was responsible for an estimated 145 000 (95% uncertainty interval [UI] 99 000-200 000) deaths among all ages in 2017. The influenza LRTI mortality rate was highest among adults older than 70 years (16.4 deaths per 100 000 [95% UI 11.6-21.9]), and the highest rate among all ages was in eastern Europe (5.2 per 100 000 population [95% UI 3.5-7.2]). We estimated that influenza LRTIs accounted for 9 459 000 (95% UI 3 709 000-22 935 000) hospitalisations due to LRTIs and 81 536 000 hospital days (24 330 000-259 851 000). We estimated that 11.5% (95% UI 10.0-12.9) of LRTI episodes were attributable to influenza, corresponding to 54 481 000 (38 465 000-73 864 000) episodes and 8 172 000 severe episodes (5 000 000-13 296 000). Interpretation This comprehensive assessment of the burden of influenza LRTIs shows the substantial annual effect of influenza on global health. Although preparedness planning will be important for potential pandemics, health loss due to seasonal influenza LRTIs should not be overlooked, and vaccine use should be considered. Efforts to improve influenza prevention measures are needed. Copyright (c) 2018 The Author(s). Published by Elsevier Ltd.

Published
2018

30. Past, present, and future of global health financing: a review of development assistance, government, out-of-pocket, and other private spending on health for 195 countries, 1995–2050

Author

Chang, A.Y., Cowling, K., Micah, A.E., Chapin, A., Chen, C.S., Ikilezi, G., Sadat, N., Tsakalos, G., Wu, J., Younker, T., Zhao, Y., Zlavog, B.S., Abbafati, C., Ahmed, A.E, Alam, K., Alipour, V., Aljunid, S.M., Almalki, M.J., Alvis-Guzman, N., Ammar, W., Andrei, C.L., Anjomshoa, M., Antonio, C.A.T., Arabloo, J., Aremu, O., Ausloos, M., Avila-Burgos, L., Awasthi, A., Ayanore, M.A., Azari, S., Azzopardi-Muscat, N., Bagherzadeh, M., Bärnighausen, T.W., Baune, B.T., Bayati, M., Belay, Y.B., Belay, Y.A., Belete, H., Berbada, D.A., Berman, A.E., Beuran, M., Bijani, A., Busse, R., Cahuana-Hurtado, L., Cámera, L.A., Catalá-López, F., Chauhan, B.G., Constantin, M-M, Crowe, C.S., Cucu, A., Dalal, K., De Neve, J-W, Deiparine, S., Demeke, F.M., Do, H.P., Dubey, M., El Tantawi, M., Eskandarieh, S., Esmaeili, R., Fakhar, M., Fazaeli, A.A., Fischer, F., Foigt, N.A., Fukumoto, T., Fullman, N., Galan, A., Gamkrelidze, A., Gezae, K.E., Ghajar, A., Ghashghaee, A., Goginashvili, K., Haakenstad, A., Haghparast Bidgoli, H., Hamidi, S., Harb, H.L., Hasanpoor, E., Hassen, H.Y., Hay, S.I., Hendrie, D., Henok, A., Heredia-Pi, I., Herteliu, C., Hoang, C.L., Hole, M.K., Homaie Rad, E., Hossain, N., Hosseinzadeh, M., Hostiuc, S., Ilesanmi, O.S., Irvani, S.S.N., Jakovljevic, M., Jalali, A., James, S.L., Jonas, J.B., Jürisson, M., Kadel, R., Karami Matin, B., Kasaeian, A., Kasaye, H.K., Kassaw, M.W., Kazemi Karyani, A., Khabiri, R., Khan, J., Khan, M.N., Khang, Y-H, Kisa, A., Kissimova-Skarbek, K., Kohler, S., Koyanagi, A., Krohn, K.J., Leung, R., Lim, L-L, Lorkowski, S., Majeed, A., Malekzadeh, R., Mansourian, M., Mantovani, L.G., Massenburg, B.B., McKee, M., Mehta, V., Meretoja, A., Meretoja, T.J., Milevska Kostova, N., Miller, T.R., Mirrakhimov, E.M., Mohajer, B., Mohammad Darwesh, A., Mohammed, S., Mohebi, F., Mokdad, A.H., Morrison, S.D., Mousavi, S.M., Muthupandian, S., Nagarajan, A.J., Nangia, V., Negoi, I., Nguyen, C.T., Nguyen, H.L.T., Nguyen, S.H., Nosratnejad, S., Oladimeji, O., Olgiati, S., Olusanya, J.O., Onwujekwe, O.E., Otstavnov, S.S., Pana, A., Pereira, D.M., Piroozi, B., Prada, S.I., Qorbani, M., Rabiee, M., Rabiee, N., Rafiei, A., Rahim, F., Rahimi-Movaghar, V., Ram, U., Ranabhat, C.L., Ranta, A., Rawaf, D.L., Rawaf, S., Rezaei, S., Roro, E.M., Rostami, A., Rubino, S., Salahshoor, M., Samy, A.M., Sanabria, J., Santos, J.V., Santric Milicevic, M.M., Sao Jose, B.P., Savic, M., Schwendicke, F., Sepanlou, S.G., Sepehrimanesh, M., Sheikh, A., Shrime, M.G, Sisay, S., Soltani, S., Soofi, M., Srinivasan, V., Tabarés-Seisdedos, R., Torre, A., Tovani-Palone, M.R., Tran, B.X., Tran, K.B., Undurraga, E.A., Valdez, P.R., van Boven, J.F.M., Vargas, V., Veisani, Y., Violante, F.S., Vladimirov, S.K., Vlassov, V., Vollmer, S., Vu, G.T., Wolfe, C.D.A., Yonemoto, N., Younis, M.Z., Yousefifard, M., Zaman, S.B., Zangeneh, A., Zegeye, El.A., Ziapour, A., Chew, A., Murray, C.J.L., Dieleman, J.L., Chang, A.Y., Cowling, K., Micah, A.E., Chapin, A., Chen, C.S., Ikilezi, G., Sadat, N., Tsakalos, G., Wu, J., Younker, T., Zhao, Y., Zlavog, B.S., Abbafati, C., Ahmed, A.E, Alam, K., Alipour, V., Aljunid, S.M., Almalki, M.J., Alvis-Guzman, N., Ammar, W., Andrei, C.L., Anjomshoa, M., Antonio, C.A.T., Arabloo, J., Aremu, O., Ausloos, M., Avila-Burgos, L., Awasthi, A., Ayanore, M.A., Azari, S., Azzopardi-Muscat, N., Bagherzadeh, M., Bärnighausen, T.W., Baune, B.T., Bayati, M., Belay, Y.B., Belay, Y.A., Belete, H., Berbada, D.A., Berman, A.E., Beuran, M., Bijani, A., Busse, R., Cahuana-Hurtado, L., Cámera, L.A., Catalá-López, F., Chauhan, B.G., Constantin, M-M, Crowe, C.S., Cucu, A., Dalal, K., De Neve, J-W, Deiparine, S., Demeke, F.M., Do, H.P., Dubey, M., El Tantawi, M., Eskandarieh, S., Esmaeili, R., Fakhar, M., Fazaeli, A.A., Fischer, F., Foigt, N.A., Fukumoto, T., Fullman, N., Galan, A., Gamkrelidze, A., Gezae, K.E., Ghajar, A., Ghashghaee, A., Goginashvili, K., Haakenstad, A., Haghparast Bidgoli, H., Hamidi, S., Harb, H.L., Hasanpoor, E., Hassen, H.Y., Hay, S.I., Hendrie, D., Henok, A., Heredia-Pi, I., Herteliu, C., Hoang, C.L., Hole, M.K., Homaie Rad, E., Hossain, N., Hosseinzadeh, M., Hostiuc, S., Ilesanmi, O.S., Irvani, S.S.N., Jakovljevic, M., Jalali, A., James, S.L., Jonas, J.B., Jürisson, M., Kadel, R., Karami Matin, B., Kasaeian, A., Kasaye, H.K., Kassaw, M.W., Kazemi Karyani, A., Khabiri, R., Khan, J., Khan, M.N., Khang, Y-H, Kisa, A., Kissimova-Skarbek, K., Kohler, S., Koyanagi, A., Krohn, K.J., Leung, R., Lim, L-L, Lorkowski, S., Majeed, A., Malekzadeh, R., Mansourian, M., Mantovani, L.G., Massenburg, B.B., McKee, M., Mehta, V., Meretoja, A., Meretoja, T.J., Milevska Kostova, N., Miller, T.R., Mirrakhimov, E.M., Mohajer, B., Mohammad Darwesh, A., Mohammed, S., Mohebi, F., Mokdad, A.H., Morrison, S.D., Mousavi, S.M., Muthupandian, S., Nagarajan, A.J., Nangia, V., Negoi, I., Nguyen, C.T., Nguyen, H.L.T., Nguyen, S.H., Nosratnejad, S., Oladimeji, O., Olgiati, S., Olusanya, J.O., Onwujekwe, O.E., Otstavnov, S.S., Pana, A., Pereira, D.M., Piroozi, B., Prada, S.I., Qorbani, M., Rabiee, M., Rabiee, N., Rafiei, A., Rahim, F., Rahimi-Movaghar, V., Ram, U., Ranabhat, C.L., Ranta, A., Rawaf, D.L., Rawaf, S., Rezaei, S., Roro, E.M., Rostami, A., Rubino, S., Salahshoor, M., Samy, A.M., Sanabria, J., Santos, J.V., Santric Milicevic, M.M., Sao Jose, B.P., Savic, M., Schwendicke, F., Sepanlou, S.G., Sepehrimanesh, M., Sheikh, A., Shrime, M.G, Sisay, S., Soltani, S., Soofi, M., Srinivasan, V., Tabarés-Seisdedos, R., Torre, A., Tovani-Palone, M.R., Tran, B.X., Tran, K.B., Undurraga, E.A., Valdez, P.R., van Boven, J.F.M., Vargas, V., Veisani, Y., Violante, F.S., Vladimirov, S.K., Vlassov, V., Vollmer, S., Vu, G.T., Wolfe, C.D.A., Yonemoto, N., Younis, M.Z., Yousefifard, M., Zaman, S.B., Zangeneh, A., Zegeye, El.A., Ziapour, A., Chew, A., Murray, C.J.L., and Dieleman, J.L.

Abstract

Background Comprehensive and comparable estimates of health spending in each country are a key input for health policy and planning, and are necessary to support the achievement of national and international health goals. Previous studies have tracked past and projected future health spending until 2040 and shown that, with economic development, countries tend to spend more on health per capita, with a decreasing share of spending from development assistance and out-of-pocket sources. We aimed to characterise the past, present, and predicted future of global health spending, with an emphasis on equity in spending across countries. Methods We estimated domestic health spending for 195 countries and territories from 1995 to 2016, split into three categories—government, out-of-pocket, and prepaid private health spending—and estimated development assistance for health (DAH) from 1990 to 2018. We estimated future scenarios of health spending using an ensemble of linear mixed-effects models with time series specifications to project domestic health spending from 2017 through 2050 and DAH from 2019 through 2050. Data were extracted from a broad set of sources tracking health spending and revenue, and were standardised and converted to inflation-adjusted 2018 US dollars. Incomplete or low-quality data were modelled and uncertainty was estimated, leading to a complete data series of total, government, prepaid private, and out-of-pocket health spending, and DAH. Estimates are reported in 2018 US dollars, 2018 purchasing-power parity-adjusted dollars, and as a percentage of gross domestic product. We used demographic decomposition methods to assess a set of factors associated with changes in government health spending between 1995 and 2016 and to examine evidence to support the theory of the health financing transition. We projected two alternative future scenarios based on higher government health spending to assess the potential ability of governments to generate more resour

Published
2019

31. Past, present, and future of global health financing: a review of development assistance, government, out-of-pocket, and other private spending on health for 195 countries, 1995-2050

Author

Chang, AY, Cowling, K, Micah, AE, Chapin, A, Chen, CS, Ikilezi, G, Sadat, N, Tsakalos, G, Wu, J, Younker, T, Zhao, Y, Zlavog, BS, Abbafati, C, Ahmed, AE, Alam, K, Alipour, V, Aljunid, SM, Almalki, MJ, Alvis-Guzman, N, Ammar, W, Andrei, CL, Anjomshoa, M, Antonio, CAT, Arabloo, J, Aremu, O, Ausloos, M, Avila-Burgos, L, Awasthi, A, Ayanore, MA, Azari, S, Azzopardi-Muscat, N, Bagherzadeh, M, Baernighausen, TW, Baune, BT, Bayati, M, Belay, YB, Belay, YA, Belete, H, Berbada, DA, Berman, AE, Beuran, M, Bijani, A, Busse, R, Cahuana-Hurtado, L, Alberto Camera, L, Catala-Lopez, F, Chauhan, BG, Constantin, M-M, Crowe, CS, Cucu, A, Dalal, K, De Neve, J-W, Deipatine, S, Demeke, FM, Huyen, PD, Dubey, M, El Tantawi, M, Eskandarieh, S, Esmaeili, R, Fakhar, M, Fazaeli, AA, Fischer, F, Foigt, NA, Fukumoto, T, Fullman, N, Galan, A, Gamkrelidze, A, Gezae, KE, Ghajar, A, Ghashghaee, A, Goginashvili, K, Haakenstad, A, Bidgoli, HH, Hamidi, S, Harb, HL, Hasanpoor, E, Hassen, HY, Hay, S, Hendrie, D, Henok, A, Heredia-Pi, I, Herteliu, C, Hoang, CL, Hole, MK, Rad, EH, Hossain, N, Hosseinzadeh, M, Hostiuc, S, Ilesanmi, OS, Irvani, SSN, Jakovljevic, M, Jalali, A, James, SL, Jonas, JB, Jurisson, M, Kadel, R, Matin, BK, Kasaeian, A, Kasaye, HK, Kassaw, MW, Karyani, AK, Khabiri, R, Khan, J, Khan, MN, Khang, Y-H, Kisa, A, Kissimova-Skarbek, K, Kohler, S, Koyanagi, A, Krohn, KJ, Leung, R, Lim, L-L, Lorkowski, S, Majeed, A, Malekzadeh, R, Mansourian, M, Mantovani, LG, Massenburg, BB, Mckee, M, Mehta, V, Meretoja, A, Meretoja, TJ, Kostova, NM, Miller, TR, Mirrakhimov, EM, Mohajer, B, Darwesh, AM, Mohammed, S, Mohebi, F, Mokdad, AH, Morrison, SD, Mousavi, SM, Muthupandian, S, Nagarajan, AJ, Nangia, V, Cuong, TN, Huong, LTN, Son, HN, Nosratnejad, S, Oladimeji, O, Olgiati, S, Olusanya, JO, Onwujekwe, OE, Otstavnov, SS, Pana, A, Pereira, DM, Piroozi, B, Prada, S, Qorbani, M, Rabiee, M, Rabiee, N, Rafiei, A, Rahim, F, Rahimi-Mcwaghar, V, Ram, U, Ranabhat, CL, Ranta, A, Rawaf, DL, Rawaf, S, Rezaei, S, Roro, EM, Rostami, A, Rubino, S, Salahshoor, M, Samy, AM, Sanabria, J, Santos, JV, Santric Milicevic, MM, Sao Jose, BP, Savic, M, Schwendicke, F, Sepanlou, SG, Sepehrimanesh, M, Sheikh, A, Shrime, MG, Sisay, S, Soltani, S, Soofi, M, Srinivasan, V, Tabares-Seisdedos, R, Torre, A, Tovani-Palone, MR, Bach, XT, Khanh, BT, Undurraga, EA, Valdez, PR, Van Boven, JFM, Vargas, V, Veisani, Y, Violante, FS, Vladimirov, SK, Vlassov, V, Vollmer, S, Giang, TV, Wolfe, CDA, Yonemoto, N, Younis, MZ, Yousefifard, M, Bin Zaman, S, Zangeneh, A, Zegeye, EA, Ziapour, A, Chew, A, Murray, CJL, Dieleman, JL, Chang, AY, Cowling, K, Micah, AE, Chapin, A, Chen, CS, Ikilezi, G, Sadat, N, Tsakalos, G, Wu, J, Younker, T, Zhao, Y, Zlavog, BS, Abbafati, C, Ahmed, AE, Alam, K, Alipour, V, Aljunid, SM, Almalki, MJ, Alvis-Guzman, N, Ammar, W, Andrei, CL, Anjomshoa, M, Antonio, CAT, Arabloo, J, Aremu, O, Ausloos, M, Avila-Burgos, L, Awasthi, A, Ayanore, MA, Azari, S, Azzopardi-Muscat, N, Bagherzadeh, M, Baernighausen, TW, Baune, BT, Bayati, M, Belay, YB, Belay, YA, Belete, H, Berbada, DA, Berman, AE, Beuran, M, Bijani, A, Busse, R, Cahuana-Hurtado, L, Alberto Camera, L, Catala-Lopez, F, Chauhan, BG, Constantin, M-M, Crowe, CS, Cucu, A, Dalal, K, De Neve, J-W, Deipatine, S, Demeke, FM, Huyen, PD, Dubey, M, El Tantawi, M, Eskandarieh, S, Esmaeili, R, Fakhar, M, Fazaeli, AA, Fischer, F, Foigt, NA, Fukumoto, T, Fullman, N, Galan, A, Gamkrelidze, A, Gezae, KE, Ghajar, A, Ghashghaee, A, Goginashvili, K, Haakenstad, A, Bidgoli, HH, Hamidi, S, Harb, HL, Hasanpoor, E, Hassen, HY, Hay, S, Hendrie, D, Henok, A, Heredia-Pi, I, Herteliu, C, Hoang, CL, Hole, MK, Rad, EH, Hossain, N, Hosseinzadeh, M, Hostiuc, S, Ilesanmi, OS, Irvani, SSN, Jakovljevic, M, Jalali, A, James, SL, Jonas, JB, Jurisson, M, Kadel, R, Matin, BK, Kasaeian, A, Kasaye, HK, Kassaw, MW, Karyani, AK, Khabiri, R, Khan, J, Khan, MN, Khang, Y-H, Kisa, A, Kissimova-Skarbek, K, Kohler, S, Koyanagi, A, Krohn, KJ, Leung, R, Lim, L-L, Lorkowski, S, Majeed, A, Malekzadeh, R, Mansourian, M, Mantovani, LG, Massenburg, BB, Mckee, M, Mehta, V, Meretoja, A, Meretoja, TJ, Kostova, NM, Miller, TR, Mirrakhimov, EM, Mohajer, B, Darwesh, AM, Mohammed, S, Mohebi, F, Mokdad, AH, Morrison, SD, Mousavi, SM, Muthupandian, S, Nagarajan, AJ, Nangia, V, Cuong, TN, Huong, LTN, Son, HN, Nosratnejad, S, Oladimeji, O, Olgiati, S, Olusanya, JO, Onwujekwe, OE, Otstavnov, SS, Pana, A, Pereira, DM, Piroozi, B, Prada, S, Qorbani, M, Rabiee, M, Rabiee, N, Rafiei, A, Rahim, F, Rahimi-Mcwaghar, V, Ram, U, Ranabhat, CL, Ranta, A, Rawaf, DL, Rawaf, S, Rezaei, S, Roro, EM, Rostami, A, Rubino, S, Salahshoor, M, Samy, AM, Sanabria, J, Santos, JV, Santric Milicevic, MM, Sao Jose, BP, Savic, M, Schwendicke, F, Sepanlou, SG, Sepehrimanesh, M, Sheikh, A, Shrime, MG, Sisay, S, Soltani, S, Soofi, M, Srinivasan, V, Tabares-Seisdedos, R, Torre, A, Tovani-Palone, MR, Bach, XT, Khanh, BT, Undurraga, EA, Valdez, PR, Van Boven, JFM, Vargas, V, Veisani, Y, Violante, FS, Vladimirov, SK, Vlassov, V, Vollmer, S, Giang, TV, Wolfe, CDA, Yonemoto, N, Younis, MZ, Yousefifard, M, Bin Zaman, S, Zangeneh, A, Zegeye, EA, Ziapour, A, Chew, A, Murray, CJL, and Dieleman, JL

Abstract

BACKGROUND: Comprehensive and comparable estimates of health spending in each country are a key input for health policy and planning, and are necessary to support the achievement of national and international health goals. Previous studies have tracked past and projected future health spending until 2040 and shown that, with economic development, countries tend to spend more on health per capita, with a decreasing share of spending from development assistance and out-of-pocket sources. We aimed to characterise the past, present, and predicted future of global health spending, with an emphasis on equity in spending across countries. METHODS: We estimated domestic health spending for 195 countries and territories from 1995 to 2016, split into three categories-government, out-of-pocket, and prepaid private health spending-and estimated development assistance for health (DAH) from 1990 to 2018. We estimated future scenarios of health spending using an ensemble of linear mixed-effects models with time series specifications to project domestic health spending from 2017 through 2050 and DAH from 2019 through 2050. Data were extracted from a broad set of sources tracking health spending and revenue, and were standardised and converted to inflation-adjusted 2018 US dollars. Incomplete or low-quality data were modelled and uncertainty was estimated, leading to a complete data series of total, government, prepaid private, and out-of-pocket health spending, and DAH. Estimates are reported in 2018 US dollars, 2018 purchasing-power parity-adjusted dollars, and as a percentage of gross domestic product. We used demographic decomposition methods to assess a set of factors associated with changes in government health spending between 1995 and 2016 and to examine evidence to support the theory of the health financing transition. We projected two alternative future scenarios based on higher government health spending to assess the potential ability of governments to generate more reso

Published
2019

32. The global burden of typhoid and paratyphoid fevers: a systematic analysis for the Global Burden of Disease Study 2017

Author

Stanaway, JD, Reiner, RC, Blacker, BF, Goldberg, EM, Khalil, IA, Troeger, CE, Andrews, JR, Bhutta, ZA, Crump, JA, Im, J, Marks, F, Mintz, E, Park, SE, Zaidi, AKM, Abebe, Z, Abejie, AN, Adedeji, IA, Ali, BA, Amare, AT, Atalay, HT, Avokpaho, EFGA, Bacha, U, Barac, A, Bedi, N, Berhane, A, Browne, AJ, Chirinos, JL, Chitheer, A, Dolecek, C, Zaki, MES, Eshrati, B, Foreman, KJ, Gemechu, A, Gupta, R, Hailu, GB, Henok, A, Hibstu, DT, Chi, LH, Ilesanmi, OS, Iyer, VJ, Kahsay, A, Kasaeian, A, Kassa, TD, Khan, EA, Khang, Y-H, El Razek, HMA, Melku, M, Mengistu, DT, Mohammad, KA, Mohammed, S, Mokdad, AH, Nachega, JB, Naheed, A, Cuong, TN, Huong, LTN, Long, HN, Nam, BN, Trang, HN, Nirayo, YL, Pangestu, T, Patton, GC, Qorbani, M, Rai, RK, Rana, SM, Ranabhat, CL, Roba, KT, Roberts, NLS, Rubino, S, Safiri, S, Sartorius, B, Sawhney, M, Shiferaw, MS, Smith, DL, Sykes, BL, Bach, XT, Tung, TT, Ukwaja, KN, Giang, TV, Linh, GV, Weldegebreal, F, Yenit, MK, Murray, CJL, Hay, SI, Stanaway, JD, Reiner, RC, Blacker, BF, Goldberg, EM, Khalil, IA, Troeger, CE, Andrews, JR, Bhutta, ZA, Crump, JA, Im, J, Marks, F, Mintz, E, Park, SE, Zaidi, AKM, Abebe, Z, Abejie, AN, Adedeji, IA, Ali, BA, Amare, AT, Atalay, HT, Avokpaho, EFGA, Bacha, U, Barac, A, Bedi, N, Berhane, A, Browne, AJ, Chirinos, JL, Chitheer, A, Dolecek, C, Zaki, MES, Eshrati, B, Foreman, KJ, Gemechu, A, Gupta, R, Hailu, GB, Henok, A, Hibstu, DT, Chi, LH, Ilesanmi, OS, Iyer, VJ, Kahsay, A, Kasaeian, A, Kassa, TD, Khan, EA, Khang, Y-H, El Razek, HMA, Melku, M, Mengistu, DT, Mohammad, KA, Mohammed, S, Mokdad, AH, Nachega, JB, Naheed, A, Cuong, TN, Huong, LTN, Long, HN, Nam, BN, Trang, HN, Nirayo, YL, Pangestu, T, Patton, GC, Qorbani, M, Rai, RK, Rana, SM, Ranabhat, CL, Roba, KT, Roberts, NLS, Rubino, S, Safiri, S, Sartorius, B, Sawhney, M, Shiferaw, MS, Smith, DL, Sykes, BL, Bach, XT, Tung, TT, Ukwaja, KN, Giang, TV, Linh, GV, Weldegebreal, F, Yenit, MK, Murray, CJL, and Hay, SI

Abstract

BACKGROUND: Efforts to quantify the global burden of enteric fever are valuable for understanding the health lost and the large-scale spatial distribution of the disease. We present the estimates of typhoid and paratyphoid fever burden from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017, and the approach taken to produce them. METHODS: For this systematic analysis we broke down the relative contributions of typhoid and paratyphoid fevers by country, year, and age, and analysed trends in incidence and mortality. We modelled the combined incidence of typhoid and paratyphoid fevers and split these total cases proportionally between typhoid and paratyphoid fevers using aetiological proportion models. We estimated deaths using vital registration data for countries with sufficiently high data completeness and using a natural history approach for other locations. We also estimated disability-adjusted life-years (DALYs) for typhoid and paratyphoid fevers. FINDINGS: Globally, 14·3 million (95% uncertainty interval [UI] 12·5-16·3) cases of typhoid and paratyphoid fevers occurred in 2017, a 44·6% (42·2-47·0) decline from 25·9 million (22·0-29·9) in 1990. Age-standardised incidence rates declined by 54·9% (53·4-56·5), from 439·2 (376·7-507·7) per 100 000 person-years in 1990, to 197·8 (172·0-226·2) per 100 000 person-years in 2017. In 2017, Salmonella enterica serotype Typhi caused 76·3% (71·8-80·5) of cases of enteric fever. We estimated a global case fatality of 0·95% (0·54-1·53) in 2017, with higher case fatality estimates among children and older adults, and among those living in lower-income countries. We therefore estimated 135·9 thousand (76·9-218·9) deaths from typhoid and paratyphoid fever globally in 2017, a 41·0% (33·6-48·3) decline from 230·5 thousand (131·2-372·6) in 1990. Overall, typhoid and paratyphoid fevers were responsible for 9·8 million (5·6-15·8) DALYs in 2017, down 43·0% (35·5-50·6) from 17·2 million (9·9-27·8) DALYs in 1990. I

Published
2019

33. Mapping 123 million neonatal, infant and child deaths between 2000 and 2017

Author

Burstein, R., Henry, N. J., Collison, M. L., Marczak, L. B., Sligar, A., Watson, S., Marquez, N., Abbasalizad-Farhangi, M., Abbasi, M., Abd-Allah, F., Abdoli, A., Abdollahi, M., Abdollahpour, I., Abdulkader, R. S., Abrigo, M. R. M., Acharya, D., Adebayo, O. M., Adekanmbi, V., Adham, D., Afshari, M., Aghaali, M., Ahmadi, K., Ahmadi, M., Ahmadpour, E., Ahmed, R., Akal, C. G., Akinyemi, J. O., Alahdab, F., Alam, N., Alamene, G. M., Alene, K. A., Alijanzadeh, M., Alinia, C., Alipour, V., Aljunid, S. M., Almalki, M. J., Al-Mekhlafi, H. M., Altirkawi, K., Alvis-Guzman, N., Amegah, A. K., Amini, S., Amit, A. M. L., Anbari, Z., Androudi, S., Anjomshoa, M., Ansari, F., Antonio, C. A. T., Arabloo, J., Arefi, Z., Aremu, O., Armoon, B., Arora, A., Artaman, A., Asadi, A., Asadi-Aliabadi, M., Ashraf-Ganjouei, A., Assadi, R., Ataeinia, B., Atre, S. R., Quintanilla, B. P. A., Ayanore, M. A., Azari, S., Babaee, E., Babazadeh, A., Badawi, A., Bagheri, S., Bagherzadeh, M., Baheiraei, N., Balouchi, A., Barac, A., Bassat, Q., Baune, B. T., Bayati, M., Bedi, N., Beghi, E., Behzadifar, M., Belay, Y. B., Bell, B., Bell, M. L., Berbada, D. A., Bernstein, R. S., Bhattacharjee, N. V., Bhattarai, S., Bhutta, Z. A., Bijani, A., Bohlouli, S., Breitborde, N. J. K., Britton, G., Browne, A. J., Nagaraja, S. B., Busse, R., Butt, Z. A., Car, J., Cárdenas, R., Castañeda-Orjuela, C. A., Cerin, E., Chanie, W. F., Chatterjee, P., Chu, D. -T, Cooper, C., Costa, V. M., Dalal, Koustuv, Dandona, L., Dandona, R., Daoud, F., Daryani, A., Das Gupta, R., Davis, I., Davis Weaver, N., Davitoiu, D. V., De Neve, J. -W, Demeke, F. M., Demoz, G. T., Deribe, K., Desai, R., Deshpande, A., Desyibelew, H. D., Dey, S., Dharmaratne, S. D., Dhimal, M., Diaz, D., Doshmangir, L., Duraes, A. R., Dwyer-Lindgren, L., Earl, L., Ebrahimi, R., Ebrahimpour, S., Effiong, A., Eftekhari, A., Ehsani-Chimeh, E., El Sayed, I., El Sayed Zaki, M., El Tantawi, M., El-Khatib, Z., Emamian, M. H., Enany, S., Eskandarieh, S., Eyawo, O., Ezalarab, M., Faramarzi, M., Fareed, M., Faridnia, R., Faro, A., Fazaeli, A. A., Fazlzadeh, M., Fentahun, N., Fereshtehnejad, S. -M, Fernandes, J. C., Filip, I., Fischer, F., Foigt, N. A., Foroutan, M., Francis, J. M., Fukumoto, T., Fullman, N., Gallus, S., Gebre, D. G., Gebrehiwot, T. T., Gebremeskel, G. G., Gessner, B. D., Geta, B., Gething, P. W., Ghadimi, R., Ghadiri, K., Ghajarzadeh, M., Ghashghaee, A., Gill, P. S., Gill, T. K., Golding, N., Gomes, N. G. M., Gona, P. N., Gopalani, S. V., Gorini, G., Goulart, B. N. G., Graetz, N., Greaves, F., Green, M. S., Guo, Y., Haj-Mirzaian, A., Hall, B. J., Hamidi, S., Haririan, H., Haro, J. M., Hasankhani, M., Hasanpoor, E., Hasanzadeh, A., Hassankhani, H., Hassen, H. Y., Hegazy, M. I., Hendrie, D., Heydarpour, F., Hird, T. R., Hoang, C. L., Hollerich, G., Rad, E. H., Hoseini-Ghahfarokhi, M., Hossain, N., Hosseini, M., Hosseinzadeh, M., Hostiuc, M., Hostiuc, S., Househ, M., Hsairi, M., Ilesanmi, O. S., Imani-Nasab, M. H., Iqbal, U., Irvani, S. S. N., Islam, N., Islam, S. M. S., JÌrisson, M., Balalami, N. J., Jalali, A., Javidnia, J., Jayatilleke, A. U., Jenabi, E., Ji, J. S., Jobanputra, Y. B., Johnson, K., Jonas, J. B., Shushtari, Z. J., Jozwiak, J. J., Kabir, A., Kahsay, A., Kalani, H., Kalhor, R., Karami, M., Karki, S., Kasaeian, A., Kassebaum, N. J., Keiyoro, P. N., Kemp, G. R., Khabiri, R., Khader, Y. S., Khafaie, M. A., Khan, E. A., Khan, J., Khan, M. S., Khang, Y. -H, Khatab, K., Khater, A., Khater, M. M., Khatony, A., Khazaei, M., Khazaei, S., Khazaei-Pool, M., Khubchandani, J., Kianipour, N., Kim, Y. J., Kimokoti, R. W., Kinyoki, D. K., Kisa, A., Kisa, S., Kolola, T., Kosen, S., Koul, P. A., Koyanagi, A., Kraemer, M. U. G., Krishan, K., Krohn, K. J., Kugbey, N., Kumar, G. A., Kumar, M., Kumar, P., Kuupiel, D., Lacey, B., Lad, S. D., Lami, F. H., Larsson, A. O., Lee, P. H., Leili, M., Levine, A. J., Li, S., Lim, L. -L, Listl, S., Longbottom, J., Lopez, J. C. F., Lorkowski, S., Magdeldin, S., Abd El Razek, H. M., Abd El Razek, M. M., Majeed, A., Maleki, A., Malekzadeh, R., Malta, D. C., Mamun, A. A., Manafi, N., Manda, A. -L, Mansourian, M., Martins-Melo, F. R., Masaka, A., Massenburg, B. B., Maulik, P. K., Mayala, B. K., Mazidi, M., McKee, M., Mehrotra, R., Mehta, K. M., Meles, G. G., Mendoza, W., Menezes, R. G., Meretoja, A., Meretoja, T. J., Mestrovic, T., Miller, T. R., Miller-Petrie, M. K., Mills, E. J., Milne, G. J., Mini, G. K., Mir, S. M., Mirjalali, H., Mirrakhimov, E. M., Mohamadi, E., Mohammad, D. K., Darwesh, A. M., Mezerji, N. M. G., Mohammed, A. S., Mohammed, S., Mokdad, A. H., Molokhia, M., Monasta, L., Moodley, Y., Moosazadeh, M., Moradi, G., Moradi, M., Moradi, Y., Moradi-Lakeh, M., Moradinazar, M., Moraga, P., Morawska, L., Mosapour, A., Mousavi, S. M., Mueller, U. O., Muluneh, A. G., Mustafa, G., Nabavizadeh, B., Naderi, M., Nagarajan, A. J., Nahvijou, A., Najafi, F., Nangia, V., Ndwandwe, D. E., Neamati, N., Negoi, I., Negoi, R. I., Ngunjiri, J. W., Thi Nguyen, H. L., Nguyen, L. H., Nguyen, S. H., Nielsen, K. R., Ningrum, D. N. A., Nirayo, Y. L., Nixon, M. R., Nnaji, C. A., Nojomi, M., Noroozi, M., Nosratnejad, S., Noubiap, J. J., Motlagh, S. N., Ofori-Asenso, R., Ogbo, F. A., Oladimeji, K. E., Olagunju, A. T., Olfatifar, M., Olum, S., Olusanya, B. O., Oluwasanu, M. M., Onwujekwe, O. E., Oren, E., Ortega-Altamirano, D. D. V., Ortiz, A., Osarenotor, O., Osei, F. B., Osgood-Zimmerman, A. E., Otstavnov, S. S., Owolabi, M. O., Mahesh, P. A., Pagheh, A. S., Pakhale, S., Panda-Jonas, S., Pandey, A., Park, E. -K, Parsian, H., Pashaei, T., Patel, S. 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N., Schaeffer, L. E., Schwebel, D. C., Sepanlou, S. G., Seyedmousavi, S., Shaahmadi, F., Shaikh, M. A., Shams-Beyranvand, M., Shamshirian, A., Shamsizadeh, M., Sharafi, K., Sharif, M., Sharif-Alhoseini, M., Sharifi, H., Sharma, J., Sharma, R., Sheikh, A., Shields, C., Shigematsu, M., Shiri, R., Shiue, I., Shuval, K., Siddiqi, T. J., Silva, J. P., Singh, J. A., Sinha, D. N., Sisay, M. M., Sisay, S., Sliwa, K., Smith, D. L., Somayaji, R., Soofi, M., Soriano, J. B., Sreeramareddy, C. T., Sudaryanto, A., Sufiyan, M. B., Sykes, B. L., Sylaja, P. N., Tabarés-Seisdedos, R., Tabb, K. M., Tabuchi, T., Taveira, N., Temsah, M. -H, Terkawi, A. S., Tessema, Z. T., Thankappan, K. R., Thirunavukkarasu, S., To, Q. G., Tovani-Palone, M. R., Tran, B. X., Tran, K. B., Ullah, I., Usman, M. S., Uthman, O. A., Vahedian-Azimi, A., Valdez, P. R., van Boven, J. F. M., Vasankari, T. J., Vasseghian, Y., Veisani, Y., Venketasubramanian, N., Violante, F. S., Vladimirov, S. K., Vlassov, V., Vos, T., Vu, G. T., Vujcic, I. S., Waheed, Y., Wakefield, J., Wang, H., Wang, Y., Wang, Y. -P, Ward, J. L., Weintraub, R. G., Weldegwergs, K. G., Weldesamuel, G. T., Westerman, R., Wiysonge, C. S., Wondafrash, D. Z., Woyczynski, L., Wu, A. -M, Xu, G., Yadegar, A., Yamada, T., Yazdi-Feyzabadi, V., Yilgwan, C. S., Yip, P., Yonemoto, N., Lebni, J. Y., Younis, M. Z., Yousefifard, M., Yousof, H. -AS. A., Yu, C., Yusefzadeh, H., Zabeh, E., Moghadam, T. Z., Bin Zaman, S., Zamani, M., Zandian, H., Zangeneh, A., Zerfu, T. A., Zhang, Y., Ziapour, A., Zodpey, S., Murray, C. J. L., Hay, S. I., Burstein, R., Henry, N. J., Collison, M. L., Marczak, L. B., Sligar, A., Watson, S., Marquez, N., Abbasalizad-Farhangi, M., Abbasi, M., Abd-Allah, F., Abdoli, A., Abdollahi, M., Abdollahpour, I., Abdulkader, R. S., Abrigo, M. R. M., Acharya, D., Adebayo, O. M., Adekanmbi, V., Adham, D., Afshari, M., Aghaali, M., Ahmadi, K., Ahmadi, M., Ahmadpour, E., Ahmed, R., Akal, C. G., Akinyemi, J. O., Alahdab, F., Alam, N., Alamene, G. M., Alene, K. A., Alijanzadeh, M., Alinia, C., Alipour, V., Aljunid, S. M., Almalki, M. J., Al-Mekhlafi, H. M., Altirkawi, K., Alvis-Guzman, N., Amegah, A. K., Amini, S., Amit, A. M. L., Anbari, Z., Androudi, S., Anjomshoa, M., Ansari, F., Antonio, C. A. T., Arabloo, J., Arefi, Z., Aremu, O., Armoon, B., Arora, A., Artaman, A., Asadi, A., Asadi-Aliabadi, M., Ashraf-Ganjouei, A., Assadi, R., Ataeinia, B., Atre, S. R., Quintanilla, B. P. A., Ayanore, M. A., Azari, S., Babaee, E., Babazadeh, A., Badawi, A., Bagheri, S., Bagherzadeh, M., Baheiraei, N., Balouchi, A., Barac, A., Bassat, Q., Baune, B. T., Bayati, M., Bedi, N., Beghi, E., Behzadifar, M., Belay, Y. B., Bell, B., Bell, M. L., Berbada, D. A., Bernstein, R. S., Bhattacharjee, N. V., Bhattarai, S., Bhutta, Z. A., Bijani, A., Bohlouli, S., Breitborde, N. J. K., Britton, G., Browne, A. J., Nagaraja, S. B., Busse, R., Butt, Z. A., Car, J., Cárdenas, R., Castañeda-Orjuela, C. A., Cerin, E., Chanie, W. F., Chatterjee, P., Chu, D. -T, Cooper, C., Costa, V. M., Dalal, Koustuv, Dandona, L., Dandona, R., Daoud, F., Daryani, A., Das Gupta, R., Davis, I., Davis Weaver, N., Davitoiu, D. V., De Neve, J. -W, Demeke, F. M., Demoz, G. T., Deribe, K., Desai, R., Deshpande, A., Desyibelew, H. D., Dey, S., Dharmaratne, S. D., Dhimal, M., Diaz, D., Doshmangir, L., Duraes, A. R., Dwyer-Lindgren, L., Earl, L., Ebrahimi, R., Ebrahimpour, S., Effiong, A., Eftekhari, A., Ehsani-Chimeh, E., El Sayed, I., El Sayed Zaki, M., El Tantawi, M., El-Khatib, Z., Emamian, M. H., Enany, S., Eskandarieh, S., Eyawo, O., Ezalarab, M., Faramarzi, M., Fareed, M., Faridnia, R., Faro, A., Fazaeli, A. A., Fazlzadeh, M., Fentahun, N., Fereshtehnejad, S. -M, Fernandes, J. C., Filip, I., Fischer, F., Foigt, N. A., Foroutan, M., Francis, J. M., Fukumoto, T., Fullman, N., Gallus, S., Gebre, D. G., Gebrehiwot, T. T., Gebremeskel, G. G., Gessner, B. D., Geta, B., Gething, P. W., Ghadimi, R., Ghadiri, K., Ghajarzadeh, M., Ghashghaee, A., Gill, P. S., Gill, T. K., Golding, N., Gomes, N. G. M., Gona, P. N., Gopalani, S. V., Gorini, G., Goulart, B. N. G., Graetz, N., Greaves, F., Green, M. S., Guo, Y., Haj-Mirzaian, A., Hall, B. J., Hamidi, S., Haririan, H., Haro, J. M., Hasankhani, M., Hasanpoor, E., Hasanzadeh, A., Hassankhani, H., Hassen, H. Y., Hegazy, M. I., Hendrie, D., Heydarpour, F., Hird, T. R., Hoang, C. L., Hollerich, G., Rad, E. H., Hoseini-Ghahfarokhi, M., Hossain, N., Hosseini, M., Hosseinzadeh, M., Hostiuc, M., Hostiuc, S., Househ, M., Hsairi, M., Ilesanmi, O. S., Imani-Nasab, M. H., Iqbal, U., Irvani, S. S. N., Islam, N., Islam, S. M. S., JÌrisson, M., Balalami, N. J., Jalali, A., Javidnia, J., Jayatilleke, A. U., Jenabi, E., Ji, J. S., Jobanputra, Y. B., Johnson, K., Jonas, J. B., Shushtari, Z. J., Jozwiak, J. J., Kabir, A., Kahsay, A., Kalani, H., Kalhor, R., Karami, M., Karki, S., Kasaeian, A., Kassebaum, N. J., Keiyoro, P. N., Kemp, G. R., Khabiri, R., Khader, Y. S., Khafaie, M. A., Khan, E. A., Khan, J., Khan, M. S., Khang, Y. -H, Khatab, K., Khater, A., Khater, M. M., Khatony, A., Khazaei, M., Khazaei, S., Khazaei-Pool, M., Khubchandani, J., Kianipour, N., Kim, Y. J., Kimokoti, R. W., Kinyoki, D. K., Kisa, A., Kisa, S., Kolola, T., Kosen, S., Koul, P. A., Koyanagi, A., Kraemer, M. U. G., Krishan, K., Krohn, K. J., Kugbey, N., Kumar, G. A., Kumar, M., Kumar, P., Kuupiel, D., Lacey, B., Lad, S. D., Lami, F. H., Larsson, A. O., Lee, P. H., Leili, M., Levine, A. J., Li, S., Lim, L. -L, Listl, S., Longbottom, J., Lopez, J. C. F., Lorkowski, S., Magdeldin, S., Abd El Razek, H. M., Abd El Razek, M. M., Majeed, A., Maleki, A., Malekzadeh, R., Malta, D. C., Mamun, A. A., Manafi, N., Manda, A. -L, Mansourian, M., Martins-Melo, F. R., Masaka, A., Massenburg, B. B., Maulik, P. K., Mayala, B. K., Mazidi, M., McKee, M., Mehrotra, R., Mehta, K. M., Meles, G. G., Mendoza, W., Menezes, R. G., Meretoja, A., Meretoja, T. J., Mestrovic, T., Miller, T. R., Miller-Petrie, M. K., Mills, E. J., Milne, G. J., Mini, G. K., Mir, S. M., Mirjalali, H., Mirrakhimov, E. M., Mohamadi, E., Mohammad, D. K., Darwesh, A. M., Mezerji, N. M. G., Mohammed, A. S., Mohammed, S., Mokdad, A. H., Molokhia, M., Monasta, L., Moodley, Y., Moosazadeh, M., Moradi, G., Moradi, M., Moradi, Y., Moradi-Lakeh, M., Moradinazar, M., Moraga, P., Morawska, L., Mosapour, A., Mousavi, S. M., Mueller, U. O., Muluneh, A. G., Mustafa, G., Nabavizadeh, B., Naderi, M., Nagarajan, A. J., Nahvijou, A., Najafi, F., Nangia, V., Ndwandwe, D. E., Neamati, N., Negoi, I., Negoi, R. I., Ngunjiri, J. W., Thi Nguyen, H. L., Nguyen, L. H., Nguyen, S. H., Nielsen, K. R., Ningrum, D. N. A., Nirayo, Y. L., Nixon, M. R., Nnaji, C. A., Nojomi, M., Noroozi, M., Nosratnejad, S., Noubiap, J. J., Motlagh, S. N., Ofori-Asenso, R., Ogbo, F. A., Oladimeji, K. E., Olagunju, A. T., Olfatifar, M., Olum, S., Olusanya, B. O., Oluwasanu, M. M., Onwujekwe, O. E., Oren, E., Ortega-Altamirano, D. D. V., Ortiz, A., Osarenotor, O., Osei, F. B., Osgood-Zimmerman, A. E., Otstavnov, S. S., Owolabi, M. O., Mahesh, P. A., Pagheh, A. S., Pakhale, S., Panda-Jonas, S., Pandey, A., Park, E. -K, Parsian, H., Pashaei, T., Patel, S. K., Pepito, V. C. F., Pereira, A., Perkins, S., Pickering, B. V., Pilgrim, T., Pirestani, M., Piroozi, B., Pirsaheb, M., Plana-Ripoll, O., Pourjafar, H., Puri, P., Qorbani, M., Quintana, H., Rabiee, M., Rabiee, N., Radfar, A., Rafiei, A., Rahim, F., Rahimi, Z., Rahimi-Movaghar, V., Rahimzadeh, S., Rajati, F., Raju, S. B., Ramezankhani, A., Ranabhat, C. L., Rasella, D., Rashedi, V., Rawal, L., Reiner Jr, R. C., Renzaho, A. M. N., Rezaei, S., Rezapour, A., Riahi, S. M., Ribeiro, A. I., Roever, L., Roro, E. M., Roser, M., Roshandel, G., Roshani, D., Rostami, A., Rubagotti, E., Rubino, S., Sabour, S., Sadat, N., Sadeghi, E., Saeedi, R., Safari, Y., Safari-Faramani, R., Safdarian, M., Sahebkar, A., Salahshoor, M. 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R., Tran, B. X., Tran, K. B., Ullah, I., Usman, M. S., Uthman, O. A., Vahedian-Azimi, A., Valdez, P. R., van Boven, J. F. M., Vasankari, T. J., Vasseghian, Y., Veisani, Y., Venketasubramanian, N., Violante, F. S., Vladimirov, S. K., Vlassov, V., Vos, T., Vu, G. T., Vujcic, I. S., Waheed, Y., Wakefield, J., Wang, H., Wang, Y., Wang, Y. -P, Ward, J. L., Weintraub, R. G., Weldegwergs, K. G., Weldesamuel, G. T., Westerman, R., Wiysonge, C. S., Wondafrash, D. Z., Woyczynski, L., Wu, A. -M, Xu, G., Yadegar, A., Yamada, T., Yazdi-Feyzabadi, V., Yilgwan, C. S., Yip, P., Yonemoto, N., Lebni, J. Y., Younis, M. Z., Yousefifard, M., Yousof, H. -AS. A., Yu, C., Yusefzadeh, H., Zabeh, E., Moghadam, T. Z., Bin Zaman, S., Zamani, M., Zandian, H., Zangeneh, A., Zerfu, T. A., Zhang, Y., Ziapour, A., Zodpey, S., Murray, C. J. L., and Hay, S. I.

Abstract

Since 2000, many countries have achieved considerable success in improving child survival, but localized progress remains unclear. To inform efforts towards United Nations Sustainable Development Goal 3.2—to end preventable child deaths by 2030—we need consistently estimated data at the subnational level regarding child mortality rates and trends. Here we quantified, for the period 2000–2017, the subnational variation in mortality rates and number of deaths of neonates, infants and children under 5 years of age within 99 low- and middle-income countries using a geostatistical survival model. We estimated that 32% of children under 5 in these countries lived in districts that had attained rates of 25 or fewer child deaths per 1,000 live births by 2017, and that 58% of child deaths between 2000 and 2017 in these countries could have been averted in the absence of geographical inequality. This study enables the identification of high-mortality clusters, patterns of progress and geographical inequalities to inform appropriate investments and implementations that will help to improve the health of all populations. © 2019, The Author(s).

Published
2019
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34. Past, present, and future of global health financing : A review of development assistance, government, out-of-pocket, and other private spending on health for 195 countries, 1995-2050

Author

Chang, A. Y., Cowling, K., Micah, A. E., Chapin, A., Chen, C. S., Ikilezi, G., Sadat, N., Tsakalos, G., Wu, J., Younker, T., Zhao, Y., Zlavog, B. S., Abbafati, C., Ahmed, A. E., Alam, K., Alipour, V., Aljunid, S. M., Almalki, M. J., Alvis-Guzman, N., Ammar, W., Andrei, C. L., Anjomshoa, M., Antonio, C. A. T., Arabloo, J., Aremu, O., Ausloos, M., Avila-Burgos, L., Awasthi, A., Ayanore, M. A., Azari, S., Azzopardi-Muscat, N., Bagherzadeh, M., BÀrnighausen, T. W., Baune, B. T., Bayati, M., Belay, Y. B., Belay, Y. A., Belete, H., Berbada, D. A., Berman, A. E., Beuran, M., Bijani, A., Busse, R., Cahuana-Hurtado, L., Cámera, L. A., Catalá-López, F., Chauhan, B. G., Constantin, M. -M, Crowe, C. S., Cucu, A., Dalal, Koustuv, De Neve, J. -W, Deiparine, S., Demeke, F. M., Do, H. P., Dubey, M., Tantawi, M. E., Eskandarieh, S., Esmaeili, R., Fakhar, M., Fazaeli, A. A., Fischer, F., Foigt, N. A., Fukumoto, T., Fullman, N., Galan, A., Gamkrelidze, A., Gezae, K. E., Ghajar, A., Ghashghaee, A., Goginashvili, K., Haakenstad, A., Bidgoli, H. H., Hamidi, S., Harb, H. L., Hasanpoor, E., Hassen, H. Y., Hay, S. I., Hendrie, D., Henok, A., Heredia-Pi, I., Herteliu, C., Hoang, C. L., Hole, M. K., Rad, E. H., Hossain, N., Hosseinzadeh, M., Hostiuc, S., Ilesanmi, O. S., Irvani, S. S. N., Jakovljevic, M., Jalali, A., James, S. L., Jonas, J. B., JÌrisson, M., Kadel, R., Matin, B. K., Kasaeian, A., Kasaye, H. K., Kassaw, M. W., Karyani, A. K., Khabiri, R., Khan, J., Khan, M. N., Khang, Y. -H, Kisa, A., Kissimova-Skarbek, K., Kohler, S., Koyanagi, A., Krohn, K. J., Leung, R., Lim, L. -L, Lorkowski, S., Majeed, A., Malekzadeh, R., Mansourian, M., Mantovani, L. G., Massenburg, B. B., Mckee, M., Mehta, V., Meretoja, A., Meretoja, T. J., Kostova, N. M., Miller, T. R., Mirrakhimov, E. M., Mohajer, B., Darwesh, A. M., Mohammed, S., Mohebi, F., Mokdad, A. H., Morrison, S. D., Mousavi, S. M., Muthupandian, S., Nagarajan, A. J., Nangia, V., Negoi, I., Nguyen, C. T., Nguyen, H. L. T., Nguyen, S. H., Nosratnejad, S., Oladimeji, O., Olgiati, S., Olusanya, J. O., Onwujekwe, O. E., Otstavnov, S. S., Pana, A., Pereira, D. M., Piroozi, B., Prada, S. I., Qorbani, M., Rabiee, M., Rabiee, N., Rafiei, A., Rahim, F., Rahimi-Movaghar, V., Ram, U., Ranabhat, C. L., Ranta, A., Rawaf, D. L., Rawaf, S., Rezaei, S., Roro, E. M., Rostami, A., Rubino, S., Salahshoor, M., Samy, A. M., Sanabria, J., Santos, J. V., Milicevic, M. M. S., Jose, B. P. S., Savic, M., Schwendicke, F., Sepanlou, S. G., Sepehrimanesh, M., Sheikh, A., Shrime, M. G., Sisay, S., Soltani, S., Soofi, M., Srinivasan, V., Tabarés-Seisdedos, R., Torre, A., Tovani-Palone, M. R., Tran, B. X., Tran, K. B., Undurraga, E. A., Valdez, P. R., Van Boven, J. F. M., Vargas, V., Veisani, Y., Violante, F. S., Vladimirov, S. K., Vlassov, V., Vollmer, S., Vu, G. T., Wolfe, C. D. A., Yonemoto, N., Younis, M. Z., Yousefifard, M., Zaman, S. B., Zangeneh, A., Zegeye, E. A., Ziapour, A., Chew, A., Murray, C. J. L., Dieleman, J. L., Network, Global Burden of Disease Health Financing Collaborator, Chang, A. Y., Cowling, K., Micah, A. E., Chapin, A., Chen, C. S., Ikilezi, G., Sadat, N., Tsakalos, G., Wu, J., Younker, T., Zhao, Y., Zlavog, B. S., Abbafati, C., Ahmed, A. E., Alam, K., Alipour, V., Aljunid, S. M., Almalki, M. J., Alvis-Guzman, N., Ammar, W., Andrei, C. L., Anjomshoa, M., Antonio, C. A. T., Arabloo, J., Aremu, O., Ausloos, M., Avila-Burgos, L., Awasthi, A., Ayanore, M. A., Azari, S., Azzopardi-Muscat, N., Bagherzadeh, M., BÀrnighausen, T. W., Baune, B. T., Bayati, M., Belay, Y. B., Belay, Y. A., Belete, H., Berbada, D. A., Berman, A. E., Beuran, M., Bijani, A., Busse, R., Cahuana-Hurtado, L., Cámera, L. A., Catalá-López, F., Chauhan, B. G., Constantin, M. -M, Crowe, C. S., Cucu, A., Dalal, Koustuv, De Neve, J. -W, Deiparine, S., Demeke, F. M., Do, H. P., Dubey, M., Tantawi, M. E., Eskandarieh, S., Esmaeili, R., Fakhar, M., Fazaeli, A. A., Fischer, F., Foigt, N. A., Fukumoto, T., Fullman, N., Galan, A., Gamkrelidze, A., Gezae, K. E., Ghajar, A., Ghashghaee, A., Goginashvili, K., Haakenstad, A., Bidgoli, H. H., Hamidi, S., Harb, H. L., Hasanpoor, E., Hassen, H. Y., Hay, S. I., Hendrie, D., Henok, A., Heredia-Pi, I., Herteliu, C., Hoang, C. L., Hole, M. K., Rad, E. H., Hossain, N., Hosseinzadeh, M., Hostiuc, S., Ilesanmi, O. S., Irvani, S. S. N., Jakovljevic, M., Jalali, A., James, S. L., Jonas, J. B., JÌrisson, M., Kadel, R., Matin, B. K., Kasaeian, A., Kasaye, H. K., Kassaw, M. W., Karyani, A. K., Khabiri, R., Khan, J., Khan, M. N., Khang, Y. -H, Kisa, A., Kissimova-Skarbek, K., Kohler, S., Koyanagi, A., Krohn, K. J., Leung, R., Lim, L. -L, Lorkowski, S., Majeed, A., Malekzadeh, R., Mansourian, M., Mantovani, L. G., Massenburg, B. B., Mckee, M., Mehta, V., Meretoja, A., Meretoja, T. J., Kostova, N. M., Miller, T. R., Mirrakhimov, E. M., Mohajer, B., Darwesh, A. M., Mohammed, S., Mohebi, F., Mokdad, A. H., Morrison, S. D., Mousavi, S. M., Muthupandian, S., Nagarajan, A. J., Nangia, V., Negoi, I., Nguyen, C. T., Nguyen, H. L. T., Nguyen, S. H., Nosratnejad, S., Oladimeji, O., Olgiati, S., Olusanya, J. O., Onwujekwe, O. E., Otstavnov, S. S., Pana, A., Pereira, D. M., Piroozi, B., Prada, S. I., Qorbani, M., Rabiee, M., Rabiee, N., Rafiei, A., Rahim, F., Rahimi-Movaghar, V., Ram, U., Ranabhat, C. L., Ranta, A., Rawaf, D. L., Rawaf, S., Rezaei, S., Roro, E. M., Rostami, A., Rubino, S., Salahshoor, M., Samy, A. M., Sanabria, J., Santos, J. V., Milicevic, M. M. S., Jose, B. P. S., Savic, M., Schwendicke, F., Sepanlou, S. G., Sepehrimanesh, M., Sheikh, A., Shrime, M. G., Sisay, S., Soltani, S., Soofi, M., Srinivasan, V., Tabarés-Seisdedos, R., Torre, A., Tovani-Palone, M. R., Tran, B. X., Tran, K. B., Undurraga, E. A., Valdez, P. R., Van Boven, J. F. M., Vargas, V., Veisani, Y., Violante, F. S., Vladimirov, S. K., Vlassov, V., Vollmer, S., Vu, G. T., Wolfe, C. D. A., Yonemoto, N., Younis, M. Z., Yousefifard, M., Zaman, S. B., Zangeneh, A., Zegeye, E. A., Ziapour, A., Chew, A., Murray, C. J. L., Dieleman, J. L., and Network, Global Burden of Disease Health Financing Collaborator

Abstract

Background: Comprehensive and comparable estimates of health spending in each country are a key input for health policy and planning, and are necessary to support the achievement of national and international health goals. Previous studies have tracked past and projected future health spending until 2040 and shown that, with economic development, countries tend to spend more on health per capita, with a decreasing share of spending from development assistance and out-of-pocket sources. We aimed to characterise the past, present, and predicted future of global health spending, with an emphasis on equity in spending across countries. Methods: We estimated domestic health spending for 195 countries and territories from 1995 to 2016, split into three categories-government, out-of-pocket, and prepaid private health spending-and estimated development assistance for health (DAH) from 1990 to 2018. We estimated future scenarios of health spending using an ensemble of linear mixed-effects models with time series specifications to project domestic health spending from 2017 through 2050 and DAH from 2019 through 2050. Data were extracted from a broad set of sources tracking health spending and revenue, and were standardised and converted to inflation-adjusted 2018 US dollars. Incomplete or low-quality data were modelled and uncertainty was estimated, leading to a complete data series of total, government, prepaid private, and out-of-pocket health spending, and DAH. Estimates are reported in 2018 US dollars, 2018 purchasing-power parity-adjusted dollars, and as a percentage of gross domestic product. We used demographic decomposition methods to assess a set of factors associated with changes in government health spending between 1995 and 2016 and to examine evidence to support the theory of the health financing transition. We projected two alternative future scenarios based on higher government health spending to assess the potential ability of governments to generate more reso

Published
2019
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37. An Italian Urban 'Fashion' The Urban 1 Programme as a Catalyst for Institutional Planning Shift

Author

Verones, S., Simone Tulumello, Rubino, S., Delponte, I., Verones, S, Tulumello, S, Rubino, S, and Delponte, I

Subjects
Italy, Italian Planning, Development Control, Development Plans, lcsh:NA9000-9428, Urban 1 Initiative, Italian planning, urban government and governance, planning theory, Strategic Environmental Assessment, Environmental Planning, Strategic Plans, Settore ICAR/21 - Urbanistica, Heritage Management, lcsh:Aesthetics of cities. City planning and beautifying
Abstract

Since the 1990s Italy has been going through changes and experiments concerning modes and tools of urban government. New methods, based on public­private partnership, on a consensual basis, were progressively adopted, overcoming the traditional authoritative mechanisms and role of public actors. The contribution of Community policies such as initiatives on urban areas, has been crucial in creating new tools, influencing the existing ones and activating new approaches to planning. This paper builds some theoretical considerations on the contributions the implementation of European Programmes has given to the changes in the conception of urban interventions and thedebated shift in urban policies from “government” to “governance”. The aim is to build a critical analysis about how the Urban 1 initiative acted as a “catalyst” for the evolution of urban practices,accelerating the innovation of the planning cultures and practices. The article examines three cities where an Urban 1 Programme has been developed: Genoa, Naples and Palermo. The cases have beenselected in order to present the variety of interpretations of EU initiatives across Italy, fostering a critical discussion on EU programmes and their relationships with local planning policies.

Published
2014

39. Antibacterial and antitumoral activities of new organotin(IV)-Schiff bases derivatives

Author

Scopelliti, M., Amato, F., Alduina, R., Cancemi, P., Rubino, S., and M. Scopelliti , F. Amato, R. Alduina, P. Cancemi, S. Rubino

Subjects
Schiff base, antibacterial, Organotin, Settore CHIM/03 - Chimica Generale E Inorganica, Schiff bases, antitumor, Settore BIO/06 - Anatomia Comparata E Citologia, Settore BIO/19 - Microbiologia Generale
Abstract

This preliminary report shows eight complexes of triorganotin(IV): Ph3SnOH and (CH3)3SnOH with four chelating imines on new synthesis. Of these ligands, two are salen-like (four coordination sites, two imidic, two phenoxidic) [1], one is a tetradentate pyrrole derivative [2] while the fourth, a vita- min B6 derivative, is pentadentate [3]. Ligands have been characterized by means of FT-IR, UV-Vis, Fluorescence, 1H- and 13C-NMR, LC-MS ESI triple quadrupole; complexes by means FT-IR, 1H- and 119Sn-NMR, LC-MS ESI, using the isotopic distribution pattern as a discriminant [4]. Geometry and nature of coordination complexes have been also evaluated using the 119Sn chemical shifts. Solid-state synthesis of the complexes (with a ball mill [5]) was also explored; such method reduces both solvent consumption and time – from 8-10 h under controlled atmosphere to about 1 h, with results identical to the wet synthesis. Antitumoral and antibacterial activities of the triorganotin (IV) complexes (BS01M, BS01P, BS02M, BS02P, BS03M, BS03P, BS04M, BS04P) were tested in vitro. In both analyses, the Shiff bases alone showed no biological activity. Antimicrobial activity was evaluated by Kirby-Bauer method against the Gram-negative Escherichia coli, and the two Gram-positive Kocuria rizophila and Staphylococcus aureus strains. All the ML2 complexes were active in inhibiting bacterial growth, with BS02P and BS03P showing the best antibacterial performance. Among the ML complexes, BS01M was not active, BS02M showed a weak antibacterial activity only against the Gram-positive bacteria, BS04M was mainly active against the Gram-negative E. coli and BS03M was active against all the tested strains. Antitumor activity was evaluated by MTT assay against cervical (HeLa), colon adenocarcinoma (HT- 29) and breast (MDA-MB231) cancer cell lines. Results showed that ML2 complexes are more active than ML ones, with HeLa cells more sensitive to treatments. These complexes (especially the ML2) showed promising results; their mechanism of action is under investigation. References 1. K. Tayade, S.K. Sahoo, S. Chopra, N. Singh, Inorganica Chimica Acta, 421, 538-543 (2014); https://doi.org/10.1016/j. ica.2014.05.014 2. S. Meghdadi, M. Amirnasr, K. Mereiter, Polyhedron, 30, 1651-1656 (2011); https://doi.org/10.1016/j.poly.2011.03.041 3. D. Sharma, S.K. Sahoo, S. Chaudhary, R. Kanta Bera, J.F. Callan, Analyst, 138, 3646-3650 (2013); https://doi.org/10.1039/ C3AN00199G 4. G. Lawson, R.H. Dahm, N. Ostah, E.D. Woodland, Applied Organometallic Chemistry, 10, 125-133 (1996); https://doi. org/10.1002/(SICI)1099-0739(199603)10:23.0.CO;2-1 5. G.A. Bowmaker, Chemical Communications, 49, 334-348 (2013); http://doi.org/10.1039/C2CC35694E 6. R. Di Stefano, M. Scopelliti, C. Pellerito, G. Casella, T. Fiore, G.C. Stocco, R. Vitturi, L. Ronconi, I.D. Sciacca, L. Pellerito, Journal of Inorganic Biochemistry, 98, 534-546 (2004); https://doi.org/10.1016/j.jinorgbio.2003.12.013 7. C. Pellerito, L. Nagy, L. Pellerito, A. Szorcsik, Journal of Organometallic Chemistry, 691, 1733-1747 (2006); https://doi. org/10.1016/j.jorganchem.2005.12.025

Published
2018

45. Energy-loss magnetic chiral dichroism (EMCD): Magnetic chiral dichroism in the electron microscope

Author

Rubino, S., Schattschneider, P., Stöger-Pollach, M., Hébert, C., Rusz, J., Calmels, L., Warot-Fonrose, B., Houdellier, F., Serin, V., Novak, P., Rubino, S., Schattschneider, P., Stöger-Pollach, M., Hébert, C., Rusz, J., Calmels, L., Warot-Fonrose, B., Houdellier, F., Serin, V., and Novak, P.

Abstract

A new technique called energy-loss magnetic chiral dichroism (EMCD) has recently been developed [P. Schattschneider, et al. Nature 441, 486 (2006)] to measure magnetic circular dichroism in the transmission electron microscope (TEM) with a spatial resolution of 10 nm. This novel technique is the TEM counterpart of x-ray magnetic circular dichroism, which is widely used for the characterization of magnetic materials with synchrotron radiation. In this paper we describe several experimental methods that can be used to measure the EMCD signal [P. Schattschneider, et al. Nature 441, 486 (2006); C. Hébert, et al. Ultramicroscopy 108(3), 277 (2008); B. Warot-Fonrose, et al. Ultramicroscopy 108(5), 393 (2008); L. Calmels, et al. Phys. Rev. B 76, 060409 (2007); P. van Aken, et al. Microsc. Microanal. 13(3), 426 (2007)] and give a review of the recent improvements of this new investigation tool. The dependence of the EMCD on several experimental conditions (such as thickness, relative orientation of beam and sample, collection and convergence angle) is investigated in the transition metals iron, cobalt, and nickel. Different scattering geometries are illustrated; their advantages and disadvantages are detailed, together with current limitations. The next realistic perspectives of this technique consist of measuring atomic specific magnetic moments, using suitable spin and orbital sum rules, [L. Calmels, et al. Phys. Rev. B 76, 060409 (2007); J. Rusz, et al. Phys. Rev. B 76, 060408 (2007)] with a resolution down to 2 to 3 nm

Published
2017

48. Molecular typing of XDR Acinetobacter baumannii strains in an Italian ICU

Author

Piana, A, Palmieri, A, Deidda, S, Mura, E, Are, B, Rubino, S, Sanna, S, Calaresu, E, Cocuzza, C, Sotgiu, G, Mura, I, COCUZZA, CLEMENTINA ELVEZIA, Mura, I., Piana, A, Palmieri, A, Deidda, S, Mura, E, Are, B, Rubino, S, Sanna, S, Calaresu, E, Cocuzza, C, Sotgiu, G, Mura, I, COCUZZA, CLEMENTINA ELVEZIA, and Mura, I.

Abstract

Objective. To investigate the antimicrobial susceptibility and clonal relationship of Acinetobacter baumannii strains isolated in an Italian ICU. Design. Epidemiological, observational, retrospective, longitudinal study. Setting and participants. The ICU of the University Hospital of Sassari, Italy. Main outcome measures. Pulsed Field Gel Electrophoresis (PFGE) and Multi Locus Sequence Typing (MLST) were used to evaluate the genomic features of the isolated strains. Results. Drug susceptibility testing for all isolated strains showed the same resistance pattern, characterized by resistance to the most important antibiotics, with the only exception of colistin. PFGE showed a very poor between-strain variability; three distinct clusters, 11, 4, and 1 isolates in size, were identified (Dice's coefficient: 92.11%). MLST showed that all isolated strains belonged to sequence type 2 (ST2). All isolates collected from the environment and the human samples were positive for the following genes: blaOXA-23, blaOXA-51-like, blaVIM-like, blaIMP-like, andISAba1; however, blaOXA-24-like, blaOXA-58-like, and blaNDM-like were not detected. Conclusions. The survey identified XDR strains belonging to the same cell clone, confirming the wide circulation and environmental persistence of this microorganism.

Published
2015

49. Effect of long-term mesoglycan treatment on fibrinogen plasma levels in patients with ischemic cerebrovascular disease

Author

V. Vecchione, V. Provitera, E. Troisi, Giuseppe Orefice, Rubino S, Pietro Biagio Carrieri, and M. Selvaggio

Subjects
Pharmacology, medicine.medical_specialty, business.industry, Antithrombin, Ischemia, Fibrinogen, medicine.disease, Gastroenterology, Endocrinology, Coagulative necrosis, Mesoglycan, Oral administration, Internal medicine, Blood plasma, Toxicity, medicine, Pharmacology (medical), business, medicine.drug
Abstract

Thirty patients who had previously had an atherothrombotic stroke received mesoglycan 50 mg BID for 3 months to evaluate the effect of the drug on plasma fibrinogen levels, antithrombin III concentration, and other coagulative parameters. After 7 days of treatment, mesoglycan significantly decreased plasma fibrinogen levels ( P P P

Published
1992

50. Immune response to influenza A(H1N1)v in HIV-infected patients

Author

Sansonetti, P, Sali, Michela, Fabbiani, M, Morandi, M, Martucci, R, Danesh, A, Delogu, Giovanni, Bermejo Martin, Jf, Sanguinetti, Maurizio, Kelvin, D, Cauda, R, Fadda, G, Rubino, S., Sali, Michela (ORCID:0000-0003-3609-2990), Delogu, Giovanni (ORCID:0000-0003-0182-8267), Sanguinetti, Maurizio (ORCID:0000-0002-9780-7059), Sansonetti, P, Sali, Michela, Fabbiani, M, Morandi, M, Martucci, R, Danesh, A, Delogu, Giovanni, Bermejo Martin, Jf, Sanguinetti, Maurizio, Kelvin, D, Cauda, R, Fadda, G, Rubino, S., Sali, Michela (ORCID:0000-0003-3609-2990), Delogu, Giovanni (ORCID:0000-0003-0182-8267), and Sanguinetti, Maurizio (ORCID:0000-0002-9780-7059)

Abstract

HIV infection is considered a risk factor for severe outcomes of influenza A(H1N1)v infection. However, data on immune response against influenza A(H1N1)v virus in HIV-infected patients are lacking.

Published
2014

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