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1. Ion emission from warm dense matter produced by irradiation with a soft x-ray free-electron laser

Author

(0000-0002-3888-8370) Krása, J., (0000-0003-3982-9978) Burian, T., (0000-0002-0776-6012) Hájková, V., (0000-0001-6930-1774) Chalupský, J., (0000-0002-1999-811X) Jelínek, Š., (0000-0001-8743-9531) Frantálová, K., (0000-0003-0784-4145) Krupka, M., (0000-0002-5939-4097) Kuglerová, Z., (0000-0001-5754-2431) Kumar Singh, S., (0000-0002-5426-1519) Vozda, V., (0000-0002-8549-0859) Vyšín, L., (0000-0002-7162-7500) Smid, M., (0000-0002-2767-9995) Perez-Martin, P., (0009-0003-3427-3082) Kühlman, M., (0000-0002-4243-0282) Pintor, J., (0000-0002-8222-8038) Cikhardt, J., (0009-0008-0393-6580) Dreimann, M., Eckermann, D., Rosenthal, F., (0000-0003-1016-0975) Vinko, S. M., (0000-0002-2872-7223) Forte, A., (0000-0001-9998-3606) Gawne, T. D., (0000-0002-0104-1424) Campbell, T., Ren, S., (0000-0002-7723-2331) Shi, Y., (0000-0003-1882-3702) Hutchinson, T., (0000-0001-6748-0422) Humphries, O. S., (0000-0003-1228-2263) Preston, T., (0000-0003-1513-9198) Makita, M., (0000-0003-0868-4745) Nakatsutsumi, M., (0000-0002-3882-510X) Pan, X., (0000-0001-9759-1166) Köhler, A., (0000-0003-0713-5824) Harmand, M., (0009-0008-2136-7780) Toleikis, S., (0000-0001-5975-776X) Falk, K., (0000-0003-4189-8753) Juha, L., (0000-0002-3888-8370) Krása, J., (0000-0003-3982-9978) Burian, T., (0000-0002-0776-6012) Hájková, V., (0000-0001-6930-1774) Chalupský, J., (0000-0002-1999-811X) Jelínek, Š., (0000-0001-8743-9531) Frantálová, K., (0000-0003-0784-4145) Krupka, M., (0000-0002-5939-4097) Kuglerová, Z., (0000-0001-5754-2431) Kumar Singh, S., (0000-0002-5426-1519) Vozda, V., (0000-0002-8549-0859) Vyšín, L., (0000-0002-7162-7500) Smid, M., (0000-0002-2767-9995) Perez-Martin, P., (0009-0003-3427-3082) Kühlman, M., (0000-0002-4243-0282) Pintor, J., (0000-0002-8222-8038) Cikhardt, J., (0009-0008-0393-6580) Dreimann, M., Eckermann, D., Rosenthal, F., (0000-0003-1016-0975) Vinko, S. M., (0000-0002-2872-7223) Forte, A., (0000-0001-9998-3606) Gawne, T. D., (0000-0002-0104-1424) Campbell, T., Ren, S., (0000-0002-7723-2331) Shi, Y., (0000-0003-1882-3702) Hutchinson, T., (0000-0001-6748-0422) Humphries, O. S., (0000-0003-1228-2263) Preston, T., (0000-0003-1513-9198) Makita, M., (0000-0003-0868-4745) Nakatsutsumi, M., (0000-0002-3882-510X) Pan, X., (0000-0001-9759-1166) Köhler, A., (0000-0003-0713-5824) Harmand, M., (0009-0008-2136-7780) Toleikis, S., (0000-0001-5975-776X) Falk, K., and (0000-0003-4189-8753) Juha, L.

Abstract

We report on an experiment performed at the FLASH2 free-electron laser (FEL) aimed at producing warm dense matter via soft x-ray isochoric heating. In the experiment, we focus on study of the ions emitted during the soft x-ray ablation process using time-of-flight electron multipliers and a shifted Maxwell–Boltzmann velocity distribution model. We find that most emitted ions are thermal, but that some impurities chemisorbed on the target surface, such as protons, are accelerated by the electrostatic field created in the plasma by escaped electrons. The morphology of the complex crater structure indicates the presence of several ion groups with varying temperatures. We find that the ion sound velocity is controlled by the ion temperature and show how the ion yield depends on the FEL radiation attenuation length in different materials.

Published
2024

2. Ion emission from plasmas produced by femtosecond pulses of short-wavelength free-electron laser radiation focused on massive targets: an overview and comparison with long-wavelength laser ablation

Author

Krása, J, Nassisi, V, Burian, T, Hájková, V, Chalupský, J, Jelinek, S, Frantálová, K, Krupka, M, Kuglerová, Z, Singh, SK, Vozda, V, Vyšín, L, Wild, J, Šmíd, M, Perez-Martin, P, Pan, X, Kühlman, M, Pintor, J, Cikhardt, J, Dreimann, M, Eckermann, D, Rosenthal, F, Vinko, SM, Forte, A, Gawne, T, Campbell, T, Ren, S, Shi, Y, Hutchinson, T, Humphries, O, Preston, T, Makita, M, Nakatsutsumi, M, Köhler, A, Harmand, M, Toleikis, S, Falk, K, and Juha, L

Abstract

We report on ion emission from plasma produced on thick targets irradiated with nanosecond and femtosecond pulses delivered by mid-ultraviolet and soft x-ray lasers, respectively. To distinguish between different ion acceleration mechanisms, the maximum kinetic energy of ions produced under different interaction conditions is plotted versus laser fluence. The transformation of the time-of-flight detector signal into ion charge density distance-of-flight spectra makes it possible to determine the mean kinetic energy of the fastest ion groups based on the influence of the acoustic velocity of ion expansion. This allows obtaining additional characteristics of the ion production. The final energy of the group of fast ions determined using the ion sound velocity model is an order of magnitude larger in the fs-XFEL interaction than in the ns-UV one. On the contrary, the ablation yield of ions in our experiment is seven orders of magnitude greater when applying ns-UV laser pulses, not only due to higher energies of UV laser pulses, but also due to a significant difference in interaction and ion formation mechanisms.

Published
2023

3. Data publication: Ion emission from warm dense matter produced by irradiation with a soft x-ray free-electron laser

Author

(0000-0002-3888-8370) Krása, J., (0000-0003-3982-9978) Burian, T., (0000-0002-0776-6012) Hájková, V., (0000-0001-6930-1774) Chalupský, J., (0000-0002-1999-811X) Jelínek, Š., (0000-0001-8743-9531) Frantálová, K., (0000-0003-0784-4145) Krupka, M., (0000-0002-5939-4097) Kuglerová, Z., (0000-0001-5754-2431) Kumar Singh, S., (0000-0002-5426-1519) Vozda, V., (0000-0002-8549-0859) Vyšín, L., (0000-0002-7162-7500) Smid, M., (0000-0002-2767-9995) Perez-Martin, P., (0009-0003-3427-3082) Kühlman, M., (0000-0002-4243-0282) Pintor, J., (0000-0002-8222-8038) Cikhardt, J., (0009-0008-0393-6580) Dreimann, M., Eckermann, D., Rosenthal, F., (0000-0003-1016-0975) Vinko, S. M., (0000-0002-2872-7223) Forte, A., (0000-0001-9998-3606) Gawne, T. D., (0000-0002-0104-1424) Campbell, T., Ren, S., (0000-0002-7723-2331) Shi, Y., (0000-0003-1882-3702) Hutchinson, T., (0000-0001-6748-0422) Humphries, O. S., (0000-0003-1228-2263) Preston, T., (0000-0003-1513-9198) Makita, M., (0000-0003-0868-4745) Nakatsutsumi, M., (0000-0002-3882-510X) Pan, X., (0000-0001-9759-1166) Köhler, A., (0000-0003-0713-5824) Harmand, M., (0009-0008-2136-7780) Toleikis, S., (0000-0001-5975-776X) Falk, K., (0000-0003-4189-8753) Juha, L., (0000-0002-3888-8370) Krása, J., (0000-0003-3982-9978) Burian, T., (0000-0002-0776-6012) Hájková, V., (0000-0001-6930-1774) Chalupský, J., (0000-0002-1999-811X) Jelínek, Š., (0000-0001-8743-9531) Frantálová, K., (0000-0003-0784-4145) Krupka, M., (0000-0002-5939-4097) Kuglerová, Z., (0000-0001-5754-2431) Kumar Singh, S., (0000-0002-5426-1519) Vozda, V., (0000-0002-8549-0859) Vyšín, L., (0000-0002-7162-7500) Smid, M., (0000-0002-2767-9995) Perez-Martin, P., (0009-0003-3427-3082) Kühlman, M., (0000-0002-4243-0282) Pintor, J., (0000-0002-8222-8038) Cikhardt, J., (0009-0008-0393-6580) Dreimann, M., Eckermann, D., Rosenthal, F., (0000-0003-1016-0975) Vinko, S. M., (0000-0002-2872-7223) Forte, A., (0000-0001-9998-3606) Gawne, T. D., (0000-0002-0104-1424) Campbell, T., Ren, S., (0000-0002-7723-2331) Shi, Y., (0000-0003-1882-3702) Hutchinson, T., (0000-0001-6748-0422) Humphries, O. S., (0000-0003-1228-2263) Preston, T., (0000-0003-1513-9198) Makita, M., (0000-0003-0868-4745) Nakatsutsumi, M., (0000-0002-3882-510X) Pan, X., (0000-0001-9759-1166) Köhler, A., (0000-0003-0713-5824) Harmand, M., (0009-0008-2136-7780) Toleikis, S., (0000-0001-5975-776X) Falk, K., and (0000-0003-4189-8753) Juha, L.

Abstract

Data set on the ion emission of different materials. Each dataset is separate and titled with the chemical symbol or abbreviation of the specific material.

Published
2023

13. "Tissue Thyrotoxicosis"

Author

Jennings, P. E., Griffin, K. E., Rosenthal, F. D., O'Malley, B. P., and Northover, B.

Published
1985

14. Modeling microcylinder-assisted conventional, interference and confocal microscopy

Author

Pahl Tobias, Hüser Lucie, Eckhardt Tim, Hagemeier Sebastian, Rosenthal Felix, Diehl Michael, and Lehmann Peter

Subjects
Physics, QC1-999
Abstract

We present how to develop virtual microcylinder- or microsphere-assisted surface topography measurement instruments. As the most critical part, the interaction between light, microcylinder and measurement object is considered based on the finite element method (FEM). Results are obtained for microcylinder-assisted conventional, interference, and confocal microscopes without necessity to repeat the time-consuming FEM simulations for each sensor.

Published
2024
Full Text
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21. Particular Treatment Procedures

Author

Deschler, Barbara, Waller, Cornelius, Engelhardt, Monika, Müller, Antonia, Luebbert, Michael, Finke, Jürgen, Bertz, Hartmut, Illerhaus, Gerald, Kaskel, Anna-Katharina, Mackensen, A., Veelken, Hendrik, Rosenthal, F. M., Müller, Claudia I., Scheele, Jürgen, and Martens, Uwe

Subjects
Umbilical Cord Blood, Stem Cell, Graft Versus Host Disease, Total Body Irradiation, Hematopoietic Cell Transplantation, Article
Published
2008

37. Proteome-wide Identification of Poly(ADP-Ribosyl)ation Targets in Different Genotoxic Stress Responses

Author

Jungmichel, S., Rosenthal, F., Altmeyer, M., Lukas, J., Hottiger, M.O., Nielsen, M.L., Jungmichel, S., Rosenthal, F., Altmeyer, M., Lukas, J., Hottiger, M.O., and Nielsen, M.L.

Abstract

Poly(ADP-ribos)ylation (PARylation) is a reversible posttranslational modification found in higher eukaryotes. However, little is known about PARylation acceptor proteins. Here, we describe a sensitive proteomics approach based on high-accuracy quantitative mass spectrometry for the identification of PARylated proteins induced under different cellular stress conditions. While confirming the majority of known PARylated substrates, our screen identifies numerous additional PARylation targets. In vivo and in vitro validation of acceptor proteins confirms that our methodology targets covalent PARylation. Nuclear proteins encompassing nucleic acid binding properties are prominently PARylated upon genotoxic stress, consistent with the nuclear localization of ARTD1/PARP1 and ARTD2/PARP2. Distinct differences in proteins becoming PARylated upon various genotoxic insults are observed, exemplified by the PARylation of RNA-processing factors THRAP3 and TAF15 under oxidative stress. High-content imaging reveals that PARylation affects the nuclear relocalization of THRAP3 and TAF15, demonstrating the potential of our approach to uncover hitherto unappreciated processes being controlled by specific genotoxic-stress-induced PARylation.

Published
2013

38. In vitro differentiation of CD34+ hematopoietic progenitor cells toward distinct dendritic cell subsets of the birbeck granule and MIIC-positive Langerhans cell and the interdigitating dendritic cell type

Author

Herbst, B., Köhler, G., Mackensen, A., Hendrik Veelken, Kulmburg, P., Rosenthal, F. M., Schaefer, H. E., Mertelsmann, R., Fisch, P., and Lindemann, A.

Subjects
Antigens, CD34, Cytoplasmic Granules, Immunophenotyping, Antigens, CD, Bone Marrow, T-Lymphocyte Subsets, Tetanus Toxoid, Humans, Ifosfamide, Cells, Cultured, Epirubicin, Etoposide, Antigen Presentation, Stem Cell Factor, Interleukin-6, Tumor Necrosis Factor-alpha, Cell Differentiation, Drug Synergism, Epithelial Cells, Dendritic Cells, HLA-DR Antigens, Hematopoietic Stem Cells, Recombinant Proteins, Langerhans Cells, Interleukin-3, Interleukin-4, Lymph Nodes, Cisplatin, Spleen
Abstract

We have demonstrated recently that Birbeck granule-positive Langerhans cells (LC) can be derived from CD34+ peripheral blood progenitor cells in the presence of a seven-cytokine cocktail (CC7-7). Here, we show that the sequential use of early-acting hematopoietic growth factors, stem cell factor, interleukin (IL)-3, and IL-6, followed on day 8 by differentiation in the two-factor combination IL-4 plus granulocytemacrophage colony-stimulating factor (GM-CSF) (CC4GM) is more efficient and allows the cells to be arrested in the LC stage for more than 1 week while continuous maturation occurs in CC7-7. Maturation of LC to interdigitating dendritic cells (DC) could specifically be induced within 60 hours by addition of tumor necrosis factor-alpha (20 ng/mL) or lipopolysaccharide (100 ng/mL). Using LC that had been enriched to greater than 90% CD1a+ cells by an immunoaffinity column, we were able to define clear-cut differences between LC and DC that corroborate data of the respective cells derived from epithelial borders (LC) or from lymph nodes (LN) and spleen (DC). Thus, molecules and functions involved in antigen (AG) uptake and processing were highly expressed in LC, while those involved in AG presentation were at maximum in DC. LC were CD1a+2 DR+2, CD23+, CD36+, CD80-, CD86-, and CD25-, while DC were CD1a+/- DR+3, CD23-, CD36-, CD80+, CD86+2, and CD25+, CD40 and CD32 were moderately expressed and nearly unchanged on maturation, in contrast to monocyte-derived DC. Macropinocytosis of fluorescein isothiocyanate-dextran was dominant in LC, as were multilamellar major histocompatibility complex (MHC) class II compartments (MIICs), which were detected by electron microscopy. The functional dichotomy of these cell types was finally supported by testing the AG-presenting cell function for tetanus toxoid to primed autologous T-cell lines, which was optimal when cells were loaded with AG as LC and subsequently induced to become DC.

Published
1996

39. Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin (IL)-2, IL-4, IL-6, IL-7, IL-10, tumor necrosis factor alpha, granulocyte-macrophage colony-stimulating factor, and gamma-interferon gene or admixed with conventional adjuvants

Author

Allione, A., Consalvo, M., Nanni, P., Lollini, P. L., Cavallo, F., Giovarelli, M., Forni, M., Gulino, A., Colombo, M. P., Dellabona, P., Hock, H., Blankenstein, T., Rosenthal, F. M., Gansbacher, B., Musso, T., Gusella, L., and Forni, G.

Subjects
Mice, Inbred BALB C, Tumor Necrosis Factor-alpha, Interleukins, Granulocyte-Macrophage Colony-Stimulating Factor, Mammary Neoplasms, Experimental, Adenocarcinoma, Transfection, Interferon-gamma, Mice, Adjuvants, Immunologic, Animals, Cytokines, Female, Immunization, Neoplasm Transplantation
Abstract

To evaluate the efficacy of vaccinations with cytokine-gene-transduced tumor cells, BALB/c mice were challenged with 1 x 10(5) parental cells of a syngeneic adenocarcinoma cell line (TSA-pc). No protection was observed in mice immunized 30 days earlier with 1 x 10(5) nonreplicating mitomycin-C-treated TSA-pc alone, or with Corynebacterium parvum or Complete Freund Adjuvant (CFA). Ten to 30% of mice immunized with nonreplicating cells engineered to produce interleukin (IL)-2, IL-4, IL-6, IL-7, IL-10, tumor necrosis factor alpha, granulocyte-macrophage colony-stimulating factor, and gamma-interferon gene were protected. Fifty % of mice immunized with replicating TSA-pc admixed with C. parvum and 80-100% of mice immunized with replicating tumor cells transduced with IL-2, IL-4, IL-7, IL-10, or gamma-interferon gene were protected. No cure was afforded by TSA cells admixed with C. parvum or CFA, nor by TSA cells engineered with IL-6, granulocyte-macrophage colony-stimulating factor, and tumor necrosis factor alpha gene injected starting 1 day after TSA-pc challenge. Complete tumor regression, however, was obtained in 10-20% of mice treated with TSA cells transduced with IL-2, IL-4, IL-7, or IL-10 and in 30% of those treated with TSA cells transduced with gamma-interferon gene.

Published
1994

49. The association of HLA-B8 with visceral disease in systemic sclerosis.

Author

Hughes, P., Gelsthorpe, K., Doughty, R. W., Rowell, N. R., Rosenthal, F. D., and Sneddon, I. B.

Subjects
SYSTEMIC scleroderma, COLLAGEN diseases, PHYTOHEMAGGLUTININS, PLANT lectins, HEMAGGLUTININ, MUCOPROTEINS
Abstract

Seventy-one patients with systemic sclerosis (SS) were typed for twenty-seven HLA alleles of the A and B loci, and the findings were related to both the extent of visceral disease and tests of cellular immune competence in a subgroup of fifty-two of these patients. Nineteen patients with widespread visceral involvement and more rapidly progressive disease had an increased frequency of HLA-B8 (relative risk = 4-14; P < 0.05) when compared to thirty-three less severely affected patients and 3000 controls. Patients with severe and progressive disease also had defective cell mediated immunity with reductions in both the numbers of circulating thymus-dependent (T) lymphocytes and in the lymphocyte transformation response to phytohaemagglutinin. These findings suggest that a genetic factor, such as an abnormal immune response gene, may be involved in the progression of the disease. [ABSTRACT FROM AUTHOR]

Published
1978

50. Gilbert's syndrome: evidence of morphological heterogeneity.

Author

Dawson, J, Carr-Locke, D L, Talbot, I C, and Rosenthal, F D

Abstract

Hepatic ultrastructure was examined by electron microscopy in 25 patients with Gilbert's syndrome and the changes in the smooth endoplasmic reticulum quantified by grid technique. Thirteen patients showed gross hypertrophy of the smooth endoplasmic reticulum (SER). These were designated Gilbert's EM Positive. The remaining 12, designated Gilbert's EM Negative, did not differ significantly from normal controls. The EM Positive group showed a significantly greater percentage response to caloric restriction (P less than 0.01) and an exaggerated response to nicotinic acid stimulation when compared with the EM Negative group and normal controls. These results suggest that SER hypertrophy is not, as previously suggested, a constant feature of Gilbert's syndrome but rather a characteristic of a distinct subpopulation. [ABSTRACT FROM PUBLISHER]

Published
1979

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