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18 results on '"Risberg, Bjørn"'

2. STAMP2 increases oxidative stress and is critical for prostate cancer

Author

Jin, Yang, Wang, Ling, Qu, Su, Sheng, Xia, Kristian, Alexandr, Mælandsmo, Gunhild M, Pällmann, Nora, Yuca, Erkan, Tekedereli, Ibrahim, Gorgulu, Kivanc, Alpay, Neslihan, Sood, Anil, Lopez-Berestein, Gabriel, Fazli, Ladan, Rennie, Paul, Risberg, Bjørn, Wæhre, Håkon, Danielsen, Håvard E, Ozpolat, Bulent, and Saatcioglu, Fahri

Published
2015
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10. [Expressions of thymidine phosphorylase, thymidylate synthase and dihydropyrimidine dehydrogenase in breast cancer and their correlations with prognosis]

Author

Li, Hui-xiang, Zh, Suo, Zhang, Yun-han, Risberg, Bjørn, Karlsson, Mats G, Nesland, Jahn M., Li, Hui-xiang, Zh, Suo, Zhang, Yun-han, Risberg, Bjørn, Karlsson, Mats G, and Nesland, Jahn M.

Abstract

Objective: To study the expression of thymidine phosphorylase (TP), thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) mRNA in breast cancer and its correlation with prognosis. Methods: Expression levels of TP, TS and DPD mRNA in 86 micro-selected breast cancer tissues and 9 normal breast tissues were detected by real-time quantitative PCR. Results: The median expression levels of TP, TS and DPD mRNA in tumor tissue and in normal tissues were 16.54, 0.38, 2.47 and 11.75, 0.25, 8.33, respectively, there were no significant differences (P >0.05). The expression levels of TP, TS and DPD mRNA showed no association with tumor size, lymph node metastasis, pathological grade and clinical stage, except that of DPD showed a negative association with patients' ages. There was no significant difference in disease-free survival or overall survival between the patients with high and low TP or DPD mRNA levels. Disease-free survival tends to be better in the patients with low TS mRNA level than those with high TS mRNA, but the difference was not significant (P=0.069), while the overall survival showed a statistically difference (59.00 month and 70.30 month) (P=0.0496). Conclusion: The expression level of TS mRNA may serve as a prognostic marker for breast cancer patients., Originalspråk: kinesiska

Published
2004

13. The expression of EGFR family ligands in breast carcinomas

Author

Suo, Zhenhe, Risberg, Bjørn, Karlsson, Mats G, Villman, Kenneth, Skovlund, Eva, Nesland, Jahn M., Suo, Zhenhe, Risberg, Bjørn, Karlsson, Mats G, Villman, Kenneth, Skovlund, Eva, and Nesland, Jahn M.

Abstract

Expression of EGF, HB-EGF, TGF-alpha, HRG-alpha, HRG-beta1, and HRG-beta3 in 100 frozen breast carcinoma materials was immunohistochemically studied. Among these tumors, 67% were positive for EGF, 53% for HB-EGF, 57% for TGF-alpha, 60% for HRG-alpha, 53% for HRG-beta1, and 63% for HRG-beta3 in the neoplastic epithelial cells. No significant associations between expression of the growth factors and clinicopathological features like tumor size, histologic grade, node status, ploidy, ER status, and c-erbB-4 expression were observed, with the exceptions that significant relations were present between EGF expression and tumor size (p = 0.01) and between HRG-beta3 expression and node status (p = 0.02). The expressions of these growth factors showed no association with cancer-specific survival by the Kaplan Meier analysis.

Published
2002
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17. Nordic Immunohistochemical Quality Control.

Author

Vyberg, Mogens, Torlakovic, Emina, Seidal, Tomas, Risberg, Bjørn, Helin, Heikki, and Nielsen, Søren

Subjects
*IMMUNOHISTOCHEMISTRY, *PATHOLOGY, *MEDICAL sciences, *DIAGNOSTIC immunohistochemistry, *PREVENTIVE medicine
Abstract

The use of immunohistochemistry by pathologists has been steadily, almost logarithmically increasing during the last decade. There is no scientific indication that this trend will reverse or slow down. At the same time, quality control issues have not followed this tempo. In particular, external quality control has been neglected. In 1999, nine Scandinavian laboratories established organization, Nordic Quality Control (NordiQC), to provide external quality control in immunohistochemistry for Denmark, Norway, Sweden, and Finland. This commentary briefly describes the work of this organization. [ABSTRACT FROM AUTHOR]

Published
2005

18. [Fine-needle aspiration cytology or core biopsy when diagnosing tumours of the breast].

Author

Berner A, Sigstad E, Reed W, and Risberg B

Subjects
Biopsy standards, Biopsy, Needle standards, Female, Humans, Sensitivity and Specificity, Breast pathology, Breast Neoplasms pathology
Abstract

Background: Fine-needle aspiration (FNA) biopsy is an established, highly accurate method for diagnosing breast lesions. In recent years, core biopsy (CB) has been increasingly used. The aim of this study was to compare the quality assessment parameters of FNA and CB in palpable and non-palpable breast lesions., Methods: Data on FNA and CB results were retrieved from the pathology database and 4367 FNA samples and corresponding histology results from 1275 lesions were compared. Quality assessment parameters were calculated using the methodology detailed in the National Health Service breast screening programme guidelines., Results: High absolute and complete specificity, absolute and complete sensitivity and low inadequate rates were found for CB compared with FNA. Low specificity for FNA was particularly seen in collagenous lesions and in submitted specimens sampled by doctors without particular experience with the FNA procedure., Interpretation: CB may be an alternative method for preoperative diagnosis when experienced cytopathologists are not available. CB is superior to FNA in fibrotic and collagenous lesions such as lobular carcinoma and radial scar due to low cellularity. FNA is the more accurate method when an immediate assessment by a cytopathologist is performed for evaluation of adequate material so that additional aspirations can be done if needed.

Published
2003

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