Author: "Rescigno A" / Search Limiters: Available in Library Collection - Searchworks@Jio Institute Digital Library Search Results

Your search keyword '"Rescigno A"' showing total 11,869 results

Start Over Author "Rescigno A" Search Limiters Available in Library Collection

11,869 results on '"Rescigno A"'

1. Non-perturbative thermal QCD at very high temperatures: computational strategy and hadronic screening masses

Author: Giusti, Leonardo, Laudicina, Davide, Bresciani, Matteo, Brida, Mattia Dalla, Harris, Tim, Pepe, Michele, and Rescigno, Pietro
Subjects: High Energy Physics - Lattice, High Energy Physics - Phenomenology
Abstract: We discuss a recently introduced strategy to study non-perturbatively thermal QCD up to temperatures of the order of the electro-weak scale, combining step scaling techniques and shifted boundary conditions. The former allow to renormalize the theory for a range of scales which spans several orders of magnitude with a moderate computational cost. Shifted boundary conditions remove the need for the zero temperature subtraction in the Equation of State. As a consequence, the simulated lattices do not have to accommodate two very different scales, the pion mass and the temperature, at the very same spacing. Effective field theory arguments guarantee that finite volume effects can be kept under control safely. With this strategy the first computation of the hadronic screening spectrum has been carried out over more than two orders of magnitude in the temperature, from $T\sim 1$ GeV up to $\sim 160$ GeV. This study is complemented with the first quantitative computation of the baryonic screening mass at next-to-leading order in the three-dimensional effective theory describing QCD at high temperatures. Both for the mesonic and the baryonic screening masses, the known leading behaviour in the coupling constant is found to be not sufficient to explain the non-perturbative data over the entire range of temperatures. These findings shed further light on the limited applicability of the perturbative approach at finite temperature, even at the electro-weak scale., Comment: arXiv admin note: substantial text overlap with arXiv:2410.12626
Published: 2024

2. CHANCES, The Chilean Cluster Galaxy Evolution Survey: selection and initial characterization of clusters and superclusters

Author: Sifón, Cristóbal, Finoguenov, Alexis, Haines, Christopher P., Jaffé, Yara, Amrutha, B. M., Demarco, Ricardo, Lima, E. V. R., Lima-Dias, Ciria, Méndez-Hernández, Hugo, Merluzzi, Paola, Monachesi, Antonela, Teixeira, Gabriel S. M., Tejos, Nicolas, Araya-Araya, Pablo, Argudo-Fernández, Maria, Baier-Soto, Raúl, Bilton, Lawrence E., Bom, C. R., Calderón, Juan Pablo, Cassarà, Letizia P., Comparat, Johan, Courtois, H. M., D'Ago, Giuseppe, Dupuy, Alexandra, Fritz, Alexander, Haack, Rodrigo F., Herpich, Fabio R., Ibar, E., Kuchner, Ulrike, Lopes, Amanda R., Lopez, Sebastian, Lösch, Elismar, McGee, Sean, de Oliveira, C. Mendes, Morelli, Lorenzo, Moretti, Alessia, Pallero, Diego, Piraino-Cerda, Franco, Pompei, Emanuela, Rescigno, U., Smith, Rory, Castelli, Analía V. Smith, Sodré Jr, Laerte, and Tempel, Elmo
Subjects: Astrophysics - Astrophysics of Galaxies
Abstract: CHANCES, the CHileAN Cluster galaxy Evolution Survey, will study the evolution of galaxies in and around ${\sim}$150 massive galaxy clusters, from the local universe out to z=0.45. CHANCES will use the new 4MOST Spectroscopic Survey Facility on the VISTA 4m telescope to obtain spectra for ${\sim}$500,000 galaxies with magnitudes $r_\mathrm{AB} < 20.5$, providing comprehensive spectroscopic coverage of each cluster out to $5r_{200}$. Its wide and deep scope will trace massive and dwarf galaxies from the surrounding filaments and groups to the cores of galaxy clusters, enabling the study of galaxy pre-processing and the role of the evolving environment on galaxy evolution. In this paper we present and characterize the sample of clusters and superclusters to be targeted by CHANCES. We used literature catalogues based on X-ray emission and Sunyaev-Zel'dovich effect to define the cluster sample in a homogeneous way, with attention to cluster mass and redshift, as well as the availability of ancillary data. We calibrated literature mass estimates from various surveys against each other and provide an initial mass estimate for each cluster, which we used to define the radial extent of the 4MOST coverage. We also present an initial assessment of the structure surrounding these clusters based on the redMaPPer red-sequence algorithm as a preview of some of the science CHANCES will enable., Comment: 11 pages, 9 figures, plus references and appendix containing catalog tables, submitted to A&A
Published: 2024

3. Non-perturbative thermal QCD at very high temperatures

Author: Giusti, Leonardo, Bresciani, Matteo, Brida, Mattia Dalla, Harris, Tim, Laudicina, Davide, Pepe, Michele, and Rescigno, Pietro
Subjects: High Energy Physics - Lattice
Abstract: We present a recently introduced strategy to study non-perturbatively thermal QCD up to temperatures of the order of the electro-weak scale, combining step scaling techniques and shifted boundary conditions. The former allow to renormalize the theory for a range of scales which spans several orders of magnitude with a moderate computational cost. Shifted boundary conditions avoid the need for the zero temperature subtraction in the Equation of State. As a consequence, the simulated lattices do not have to accommodate two very different scales, the pion mass and the temperature. Effective field theory arguments guarantee that finite volume effects can be kept under control safely. As a first application of this strategy, we present the results of the computation of the hadronic screening spectrum in QCD with $N_f=3$ flavours of massless quarks for temperatures from $T\sim 1$ GeV up to $\sim 160$ GeV., Comment: 6 pages, 3 figures, Proceedings of the 42nd International Conference on High Energy Physics (ICHEP2024)
Published: 2024

4. An Efficient Algorithm for Group Testing with Runlength Constraints

Author: Dalai, Marco, Della Fiore, Stefano, Rescigno, Adele A., and Vaccaro, Ugo
Subjects: Computer Science - Information Theory, Computer Science - Data Structures and Algorithms, 05D40
Abstract: In this paper, we provide an efficient algorithm to construct almost optimal $(k,n,d)$-superimposed codes with runlength constraints. A $(k,n,d)$-superimposed code of length $t$ is a $t \times n$ binary matrix such that any two 1's in each column are separated by a run of at least $d$ 0's, and such that for any column $\mathbf{c}$ and any other $k-1$ columns, there exists a row where $\mathbf{c}$ has $1$ and all the remaining $k-1$ columns have $0$. These combinatorial structures were introduced by Agarwal et al. [1], in the context of Non-Adaptive Group Testing algorithms with runlength constraints. By using Moser and Tardos' constructive version of the Lov\'asz Local Lemma, we provide an efficient randomized Las Vegas algorithm of complexity $\Theta(t n^2)$ for the construction of $(k,n,d)$-superimposed codes of length $t=O(dk\log n +k^2\log n)$. We also show that the length of our codes is shorter, for $n$ sufficiently large, than that of the codes whose existence was proved in [1]., Comment: Accepted for publication in Discrete Applied Mathematics
Published: 2024

5. Benchmarking the design of the cryogenics system for the underground argon in DarkSide-20k

Author: Collaboration, DarkSide-20k, Acerbi, F., Adhikari, P., Agnes, P., Ahmad, I., Albergo, S., Albuquerque, I. F. M., Alexander, T., Alton, A. K., Amaudruz, P., Angiolilli, M., Aprile, E., Ardito, R., Corona, M. Atzori, Auty, D. J., Ave, M., Avetisov, I. C., Azzolini, O., Back, H. O., Balmforth, Z., Olmedo, A. Barrado, Barrillon, P., Batignani, G., Bhowmick, P., Blua, S., Bocci, V., Bonivento, W., Bottino, B., Boulay, M. G., Buchowicz, A., Bussino, S., Busto, J., Cadeddu, M., Cadoni, M., Calabrese, R., Camillo, V., Caminata, A., Canci, N., Capra, A., Caravati, M., Cárdenas-Montes, M., Cargioli, N., Carlini, M., Castellani, A., Castello, P., Cavalcante, P., Cebrian, S., Ruiz, J. Cela, Chashin, S., Chepurnov, A., Cifarelli, L., Cintas, D., Citterio, M., Cleveland, B., Coadou, Y., Cocco, V., Colaiuda, D., Vilda, E. Conde, Consiglio, L., Costa, B. S., Czubak, M., D'Aniello, M., D'Auria, S., Rolo, M. D. Da Rocha, Darbo, G., Davini, S., De Cecco, S., De Guido, G., Dellacasa, G., Derbin, A. V., Devoto, A., Di Capua, F., Di Ludovico, A., Di Noto, L., Di Stefano, P., Dias, L. K., Mairena, D. Díaz, Ding, X., Dionisi, C., Dolganov, G., Dordei, F., Dronik, V., Elersich, A., Ellingwood, E., Erjavec, T., Diaz, M. Fernandez, Ficorella, A., Fiorillo, G., Franchini, P., Franco, D., Gatti, H. Frandini, Frolov, E., Gabriele, F., Gahan, D., Galbiati, C., Galiński, G., Gallina, G., Gallus, G., Garbini, M., Abia, P. Garcia, Gawdzik, A., Gendotti, A., Ghisi, A., Giovanetti, G. K., Casanueva, V. Goicoechea, Gola, A., Grandi, L., Grauso, G., di Cortona, G. Grilli, Grobov, A., Gromov, M., Guerzoni, M., Gulino, M., Guo, C., Hackett, B. R., Hallin, A., Hamer, A., Haranczyk, M., Harrop, B., Hessel, T., Hill, S., Horikawa, S., Hu, J., Hubaut, F., Hucker, J., Hugues, T., Hungerford, E. V., Ianni, A., Ippolito, V., Jamil, A., Jillings, C., Jois, S., Kachru, P., Keloth, R., Kemmerich, N., Kemp, A., Kendziora, C. L., Kimura, M., Kish, A., Kondo, K., Korga, G., Kotsiopoulou, L., Koulosousas, S., Kubankin, A., Kunzé, P., Kuss, M., Kuźniak, M., Kuzwa, M., La Commara, M., Lai, M., Guirriec, E. Le, Leason, E., Leoni, A., Lidey, L., Lissia, M., Luzzi, L., Lychagina, O., Macfadyen, O., Machulin, I. N., Manecki, S., Manthos, I., Mapelli, L., Marasciulli, A., Mari, S. M., Mariani, C., Maricic, J., Martinez, M., Martoff, C. J., Matteucci, G., Mavrokoridis, K., McDonald, A. B., Mclaughlin, J., Merzi, S., Messina, A., Milincic, R., Minutoli, S., Mitra, A., Moharana, A., Moioli, S., Monroe, J., Moretti, E., Morrocchi, M., Mroz, T., Muratova, V. N., Murphy, M., Murra, M., Muscas, C., Musico, P., Nania, R., Nessi, M., Nieradka, G., Nikolopoulos, K., Nikoloudaki, E., Nowak, J., Olchanski, K., Oleinik, A., Oleynikov, V., Organtini, P., de Solórzano, A. Ortiz, Pallavicini, M., Pandola, L., Pantic, E., Paoloni, E., Papi, D., Pastuszak, G., Paternoster, G., Peck, A., Pegoraro, P. A., Pelczar, K., Pellegrini, L. A., Perez, R., Perotti, F., Pesudo, V., Piacentini, S. I., Pino, N., Plante, G., Pocar, A., Poehlmann, M., Pordes, S., Pralavorio, P., Price, D., Puglia, S., Bazetto, M. Queiroga, Ragusa, F., Ramachers, Y., Ramirez, A., Ravinthiran, S., Razeti, M., Renshaw, A. L., Rescigno, M., Retiere, F., Rignanese, L. P., Rivetti, A., Roberts, A., Roberts, C., Rogers, G., Romero, L., Rossi, M., Rubbia, A., Rudik, D., Sabia, M., Salomone, P., Samoylov, O., Sandford, E., Sanfilippo, S., Santone, D., Santorelli, R., Santos, E. M., Savarese, C., Scapparone, E., Schillaci, G., Schuckman II, F. G., Scioli, G., Semenov, D. A., Shalamova, V., Sheshukov, A., Simeone, M., Skensved, P., Skorokhvatov, M. D., Smirnov, O., Smirnova, T., Smith, B., Sotnikov, A., Spadoni, F., Spangenberg, M., Stefanizzi, R., Steri, A., Stornelli, V., Stracka, S., Sulis, S., Sung, A., Sunny, C., Suvorov, Y., Szelc, A. M., Taborda, O., Tartaglia, R., Taylor, A., Taylor, J., Tedesco, S., Testera, G., Thieme, K., Thompson, A., Thorpe, T. N., Tonazzo, A., Torres-Lara, S., Tricomi, A., Unzhakov, E. V., Vallivilayil, T. J., Van Uffelen, M., Velazquez-Fernandez, L., Viant, T., Viel, S., Vishneva, A., Vogelaar, R. B., Vossebeld, J., Vyas, B., Wada, M., Walczak, M. B., Wang, H., Wang, Y., Westerdale, S., Williams, L., Wojaczyński, R., Wojcik, M., Wojcik, M. M., Wright, T., Xiao, X., Xie, Y., Yang, C., Yin, J., Zabihi, A., Zakhary, P., Zani, A., Zhang, Y., Zhu, T., Zichichi, A., Zuzel, G., and Zykova, M. P.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: DarkSide-20k (DS-20k) is a dark matter detection experiment under construction at the Laboratori Nazionali del Gran Sasso (LNGS) in Italy. It utilises ~100 t of low radioactivity argon from an underground source (UAr) in its inner detector, with half serving as target in a dual-phase time projection chamber (TPC). The UAr cryogenics system must maintain stable thermodynamic conditions throughout the experiment's lifetime of >10 years. Continuous removal of impurities and radon from the UAr is essential for maximising signal yield and mitigating background. We are developing an efficient and powerful cryogenics system with a gas purification loop with a target circulation rate of 1000 slpm. Central to its design is a condenser operated with liquid nitrogen which is paired with a gas heat exchanger cascade, delivering a combined cooling power of >8 kW. Here we present the design choices in view of the DS-20k requirements, in particular the condenser's working principle and the cooling control, and we show test results obtained with a dedicated benchmarking platform at CERN and LNGS. We find that the thermal efficiency of the recirculation loop, defined in terms of nitrogen consumption per argon flow rate, is 95 % and the pressure in the test cryostat can be maintained within $\pm$(0.1-0.2) mbar. We further detail a 5-day cool-down procedure of the test cryostat, maintaining a cooling rate typically within -2 K/h, as required for the DS-20k inner detector. Additionally, we assess the circuit's flow resistance, and the heat transfer capabilities of two heat exchanger geometries for argon phase change, used to provide gas for recirculation. We conclude by discussing how our findings influence the finalisation of the system design, including necessary modifications to meet requirements and ongoing testing activities., Comment: 45 pages, 24 figures
Published: 2024

6. Spanning Trees Minimizing Branching Costs

Author: Gargano, Luisa and Rescigno, Adele A.
Subjects: Computer Science - Data Structures and Algorithms, Computer Science - Computational Complexity, F.2.2
Abstract: The Minimum Branch Vertices Spanning Tree problem aims to find a spanning tree $T$ in a given graph $G$ with the fewest branch vertices, defined as vertices with a degree three or more in $T$. This problem, known to be NP-hard, has attracted significant attention due to its importance in network design and optimization. Extensive research has been conducted on the algorithmic and combinatorial aspects of this problem, with recent studies delving into its fixed-parameter tractability. In this paper, we focus primarily on the parameter modular-width. We demonstrate that finding a spanning tree with the minimum number of branch vertices is Fixed-Parameter Tractable (FPT) when considered with respect to modular-width. Additionally, in cases where each vertex in the input graph has an associated cost for serving as a branch vertex, we prove that the problem of finding a spanning tree with the minimum branch cost (i.e., minimizing the sum of the costs of branch vertices) is FPT with respect to neighborhood diversity.
Published: 2024

7. DarkSide-20k sensitivity to light dark matter particles

Author: Collaboration, DarkSide-20k, Acerbi, F., Adhikari, P., Agnes, P., Ahmad, I., Albergo, S., Albuquerque, I. F. M., Alexander, T., Alton, A. K., Amaudruz, P., Angiolilli, M., Aprile, E., Ardito, R., Corona, M. Atzori, Auty, D. J., Ave, M., Avetisov, I. C., Azzolini, O., Back, H. O., Balmforth, Z., Olmedo, A. Barrado, Barrillon, P., Batignani, G., Bhowmick, P., Blua, S., Bocci, V., Bonivento, W., Bottino, B., Boulay, M. G., Buchowicz, A., Bussino, S., Busto, J., Cadeddu, M., Cadoni, M., Calabrese, R., Camillo, V., Caminata, A., Canci, N., Capra, A., Caravati, M., Cárdenas-Montes, M., Cargioli, N., Carlini, M., Castellani, A., Castello, P., Cavalcante, P., Cebrian, S., Ruiz, J. M. Cela, Chashin, S., Chepurnov, A., Cifarelli, L., Cintas, D., Citterio, M., Cleveland, B., Coadou, Y., Cocco, V., Colaiuda, D., Vilda, E. Conde, Consiglio, L., Costa, B. S., Czubak, M., D'Aniello, M., D'Auria, S., Rolo, M. D. Da Rocha, Darbo, G., Davini, S., De Cecco, S., De Guido, G., Dellacasa, G., Derbin, A. V., Devoto, A., Di Capua, F., Di Ludovico, A., Di Noto, L., Di Stefano, P., Dias, L. K., Mairena, D. Díaz, Ding, X., Dionisi, C., Dolganov, G., Dordei, F., Dronik, V., Elersich, A., Ellingwood, E., Erjavec, T., Diaz, M. Fernandez, Ficorella, A., Fiorillo, G., Franchini, P., Franco, D., Gatti, H. Frandini, Frolov, E., Gabriele, F., Gahan, D., Galbiati, C., Galiński, G., Gallina, G., Gallus, G., Garbini, M., Abia, P. Garcia, Gawdzik, A., Gendotti, A., Ghisi, A., Giovanetti, G. K., Casanueva, V. Goicoechea, Gola, A., Grandi, L., Grauso, G., di Cortona, G. Grilli, Grobov, A., Gromov, M., Guerzoni, M., Gulino, M., Guo, C., Hackett, B. R., Hallin, A., Hamer, A., Haranczyk, M., Harrop, B., Hessel, T., Hill, S., Horikawa, S., Hu, J., Hubaut, F., Hucker, J., Hugues, T., Hungerford, E. V., Ianni, A., Ippolito, V., Jamil, A., Jillings, C., Jois, S., Kachru, P., Keloth, R., Kemmerich, N., Kemp, A., Kendziora, C. L., Kimura, M., Kondo, K., Korga, G., Kotsiopoulou, L., Koulosousas, S., Kubankin, A., Kunzé, P., Kuss, M., Kuźniak, M., Kuzwa, M., La Commara, M., Lai, M., Guirriec, E. Le, Leason, E., Leoni, A., Lidey, L., Lissia, M., Luzzi, L., Lychagina, O., Macfadyen, O., Machulin, I. N., Manecki, S., Manthos, I., Mapelli, L., Marasciulli, A., Mari, S. M., Mariani, C., Maricic, J., Martinez, M., Martoff, C. J., Matteucci, G., Mavrokoridis, K., McDonald, A. B., Mclaughlin, J., Merzi, S., Messina, A., Milincic, R., Minutoli, S., Mitra, A., Moioli, S., Monroe, J., Moretti, E., Morrocchi, M., Mroz, T., Muratova, V. N., Murphy, M., Murra, M., Muscas, C., Musico, P., Nania, R., Nessi, M., Nieradka, G., Nikolopoulos, K., Nikoloudaki, E., Nowak, J., Olchanski, K., Oleinik, A., Oleynikov, V., Organtini, P., de Solórzano, A. Ortiz, Pallavicini, M., Pandola, L., Pantic, E., Paoloni, E., Papi, D., Pastuszak, G., Paternoster, G., Peck, A., Pegoraro, P. A., Pelczar, K., Pellegrini, L. A., Perez, R., Perotti, F., Pesudo, V., Piacentini, S. I., Pino, N., Plante, G., Pocar, A., Poehlmann, M., Pordes, S., Pralavorio, P., Price, D., Puglia, S., Bazetto, M. Queiroga, Ragusa, F., Ramachers, Y., Ramirez, A., Ravinthiran, S., Razeti, M., Renshaw, A. L., Rescigno, M., Retiere, F., Rignanese, L. P., Rivetti, A., Roberts, A., Roberts, C., Rogers, G., Romero, L., Rossi, M., Rubbia, A., Rudik, D., Sabia, M., Salomone, P., Samoylov, O., Sandford, E., Sanfilippo, S., Santone, D., Santorelli, R., Santos, E. M., Savarese, C., Scapparone, E., Schillaci, G., Schuckman II, F. G., Scioli, G., Semenov, D. A., Shalamova, V., Sheshukov, A., Simeone, M., Skensved, P., Skorokhvatov, M. D., Smirnov, O., Smirnova, T., Smith, B., Sotnikov, A., Spadoni, F., Spangenberg, M., Stefanizzi, R., Steri, A., Stornelli, V., Stracka, S., Sulis, S., Sung, A., Sunny, C., Suvorov, Y., Szelc, A. M., Taborda, O., Tartaglia, R., Taylor, A., Taylor, J., Tedesco, S., Testera, G., Thieme, K., Thompson, A., Tonazzo, A., Torres-Lara, S., Tricomi, A., Unzhakov, E. V., Vallivilayil, T. J., Van Uffelen, M., Velazquez-Fernandez, L., Viant, T., Viel, S., Vishneva, A., Vogelaar, R. B., Vossebeld, J., Vyas, B., Walczak, M. B., Wang, Y., Wang, H., Westerdale, S., Williams, L., Wojaczyński, R., Wojcik, M., Wojcik, M. M., Wright, T., Xie, Y., Yang, C., Yin, J., Zabihi, A., Zakhary, P., Zani, A., Zhang, Y., Zhu, T., Zichichi, A., Zuzel, G., and Zykova, M. P.
Subjects: High Energy Physics - Experiment, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: The dual-phase liquid argon time projection chamber is presently one of the leading technologies to search for dark matter particles with masses below 10 GeV/c$^2$. This was demonstrated by the DarkSide-50 experiment with approximately 50 kg of low-radioactivity liquid argon as target material. The next generation experiment DarkSide-20k, currently under construction, will use 1,000 times more argon and is expected to start operation in 2027. Based on the DarkSide-50 experience, here we assess the DarkSide-20k sensitivity to models predicting light dark matter particles, including Weakly Interacting Massive Particles (WIMPs) and sub-GeV/c$^2$ particles interacting with electrons in argon atoms. With one year of data, a sensitivity improvement to dark matter interaction cross-sections by at least one order of magnitude with respect to DarkSide-50 is expected for all these models. A sensitivity to WIMP--nucleon interaction cross-sections below $1\times10^{-42}$ cm$^2$ is achievable for WIMP masses above 800 MeV/c$^2$. With 10 years exposure, the neutrino fog can be reached for WIMP masses around 5 GeV/c$^2$., Comment: submitted to Nature Communications
Published: 2024

8. Tracking ultrafast non-adiabatic dissociation dynamics of the deuterated water dication molecule

Author: Iskandar, W, Rescigno, TN, Orel, AE, Larsen, KA, Severt, T, Streeter, ZL, Jochim, B, Griffin, B, Call, D, Davis, V, McCurdy, CW, Lucchese, RR, Williams, JB, Ben-Itzhak, I, Slaughter, DS, and Weber, T
Subjects: Physical Sciences, Chemical Sciences, Atomic, Molecular and Optical Physics, Physical Chemistry, Affordable and Clean Energy, Engineering, Chemical Physics, Chemical sciences, Physical sciences
Abstract: We applied reaction microscopy to elucidate fast non-adiabatic dissociation dynamics of deuterated water molecules after direct photo-double ionization at 61 eV with synchrotron radiation. For the very rare D+ + O+ + D breakup channel, the particle momenta, angular, and energy distributions of electrons and ions, measured in coincidence, reveal distinct electronic dication states and their dissociation pathways via spin-orbit coupling and charge transfer at crossings and seams on the potential energy surfaces. Notably, we could distinguish between direct and fast sequential dissociation scenarios. For the latter case, our measurements reveal the geometry and orientation of the deuterated water molecule with respect to the polarization vector that leads to this rare 3-body molecular breakup channel. Aided by multi-reference configuration-interaction calculations, the dissociation dynamics could be traced on the relevant potential energy surfaces and particularly their crossings and seams. This approach also unraveled the ultrafast time scales governing these processes.
Published: 2024

9. The Mean Longitudinal Magnetic Field and its Uses in Radial-Velocity Surveys

Author: Rescigno, F., Mortier, A., Dumusque, X., Lakeland, B. S., Haywood, R., Piskunov, N., Nicholson, B. A., López-Morales, M., Dalal, S., Cretignier, M., Klein, B., Cameron, A. Collier, Ghedina, A., Gonzalez, M., Cosentino, R., Sozzetti, A., and Saar, S. H.
Subjects: Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: This work focuses on the analysis of the mean longitudinal magnetic field as a stellar activity tracer in the context of small exoplanet detection and characterisation in radial-velocity (RV) surveys. We use SDO/HMI filtergrams to derive Sun-as-a-star magnetic field measurements, and show that the mean longitudinal magnetic field is an excellent rotational period detector and a useful tracer of the solar magnetic cycle. To put these results into context, we compare the mean longitudinal magnetic field to three common activity proxies derived from HARPS-N Sun-as-a-star data: the full-width at half-maximum, the bisector span and the S-index. The mean longitudinal magnetic field does not correlate with the RVs and therefore cannot be used as a one-to-one proxy. However, with high cadence and a long baseline, the mean longitudinal magnetic field outperforms all other considered proxies as a solar rotational period detector, and can be used to inform our understanding of the physical processes happening on the surface of the Sun. We also test the mean longitudinal magnetic field as a "stellar proxy" on a reduced solar dataset to simulate stellar-like observational sampling. With a Gaussian Process regression analysis, we confirm that the solar mean longitudinal magnetic field is the most effective of the considered indicators, and is the most efficient rotational period indicator over different levels of stellar activity. This work highlights the need for polarimetric time series observations of stars., Comment: 23 pages, 27 figures
Published: 2024

10. Giant splitting of the hydrogen rotational eigenenergies in the C$_2$ filled ice

Author: Di Cataldo, Simone, Rescigno, Maria, Monacelli, Lorenzo, Ranieri, Umbertoluca, Gaal, Richard, Klotz, Stefan, Ollivier, Jacques, Koza, Michael Marek, De Michele, Cristiano, and Bove, Livia Eleonora
Subjects: Condensed Matter - Soft Condensed Matter, Quantum Physics
Abstract: Hydrogen hydrates present a rich phase diagram influenced by both pressure and temperature, with the so-called C$_2$ phase emerging prominently above 2.5 GPa. In this phase, hydrogen molecules are densely packed within a cubic ice-like lattice and the interaction with the surrounding water molecules profoundly affects their quantum rotational dynamics. Herein, we delve into this intricate interplay by directly solving the Schr\"{o}dinger's equation for a quantum H$_2$ rotor in the C$_2$ crystal field at finite temperature, generated through Density Functional Theory. Our calculations reveal a giant energy splitting relative to the magnetic quantum number of $\pm$3.2 meV for $l=1$. Employing inelastic neutron scattering, we experimentally measure the energy levels of H$_2$ within the C$_2$ phase at 6.0 and 3.4 GPa and low temperatures, finding remarkable agreement with our theoretical predictions. These findings underscore the pivotal role of hydrogen--water interactions in dictating the rotational behavior of the hydrogen molecules within the C$_2$ phase and indicate heightened induced-dipole interactions compared to other hydrogen hydrates., Comment: 4 Figures
Published: 2024

11. Investigating stellar activity through eight years of Sun-as-a-star observations

Author: Klein, Baptiste, Aigrain, Suzanne, Cretignier, Michael, Moulla, Khaled Al, Dumusque, Xavier, Barragán, Oscar, Yu, Haochuan, Mortier, Annelies, Rescigno, Federica, Cameron, Andrew Collier, López-Morales, Mercedes, Meunier, Nadège, Sozzetti, Alessandro, and O'Sullivan, Niamh K.
Subjects: Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Solar and Stellar Astrophysics
Abstract: Stellar magnetic activity induces both distortions and Doppler-shifts in the absorption line profiles of Sun-like stars. Those effects produce apparent radial velocity (RV) signals which greatly hamper the search for potentially habitable, Earth-like planets. In this work, we investigate these distortions in the Sun using cross-correlation functions (CCFs), derived from intensive monitoring with the high-precision spectrograph HARPS-N. We show that the RV signal arising from line-shape variations on time-scales associated with the solar rotation and activity cycle can be robustly extracted from the data, reducing the RV dispersion by half. Once these have been corrected, activity-induced Doppler-shifts remain, that are modulated at the solar rotation period, and that are most effectively modelled in the time domain, using Gaussian Processes (GPs). Planet signatures are still best retrieved with multi-dimensonal GPs, when activity is jointly modelled from the raw RVs and indicators of the line width or of the Ca II H and K emission. After GP modelling, the residual RVs exhibit a dispersion of 0.6-0.8 m/s, likely to be dominated by signals induced by super-granulation. Finally, we find that the statistical properties of the RVs evolve significantly over time, and that this evolution is primarily driven by sunspots, which control the smoothness of the signal. Such evolution, which reduces the sensitivity to long-period planet signatures, is no longer seen in the activity-induced Doppler-shifts, which is promising for long term RV monitoring surveys such as the Terra Hunting Experiment or the PLATO follow-up campaign., Comment: Accepted by MNRAS on the 2024 May 20. 17 pages, 14 figures (plus 8 pages of Appendix, 9 Appendix figures)
Published: 2024

12. Baryonic screening masses in QCD at high temperature

Author: Giusti, L., Harris, T., Laudicina, D., Pepe, M., and Rescigno, P.
Subjects: High Energy Physics - Lattice, High Energy Physics - Phenomenology
Abstract: We compute the baryonic screening masses with nucleon quantum numbers and its negative parity partner in thermal QCD with $N_f=3$ massless quarks for a wide range of temperatures, from $T \sim 1$ GeV up to $\sim 160$ GeV. The computation is performed by Monte Carlo simulations of lattice QCD with $O(a)$-improved Wilson fermions by exploiting a recently proposed strategy to study non-perturbatively QCD at very high temperature. Very large spatial extensions are considered in order to have negligible finite volume effects. For each temperature we have simulated $3$ or $4$ values of the lattice spacing, so as to perform the continuum limit extrapolation with confidence at a few permille accuracy. The degeneracy of the positive and negative parity-state screening masses, expected from Ward identities associated to non-singlet axial transformations, provides further evidence for the restoration of chiral symmetry in the high temperature regime of QCD. In the entire range of temperatures explored, the baryonic masses deviate from the free theory result, $3 \pi T$, by $4$-$8\%$. The contribution due to the interactions is clearly visible up to the highest temperature considered, and cannot be explained by the expected leading behavior in the QCD coupling constant $g$ over the entire range of temperatures explored., Comment: 8 pages, 4 tables and 4 figures. arXiv admin note: substantial text overlap with arXiv:2112.05427
Published: 2024

13. Baryonic thermal screening mass at NLO

Author: Giusti, Leonardo, Laine, M., Laudicina, Davide, Pepe, Michele, and Rescigno, Pietro
Subjects: High Energy Physics - Phenomenology, High Energy Physics - Lattice
Abstract: We determine the resummed 1-loop correction to a baryonic thermal screening mass. The calculation is carried out in the framework of a dimensionally reduced effective theory, where quarks are heavy fields due to their non-zero Matsubara frequencies. The correction due to interactions is computed at O($g^2_{ }$) in the coupling constant. In order to solve a 3-body Schr\"odinger equation, we exploit a two-dimensional generalization of the hyperspherical harmonics method. At electroweak scale temperatures, the NLO correction represents a $\sim 4.6 \%$ increase of the free-theory value $3\pi T$ of the screening mass., Comment: 22 pages. v2: minor updates
Published: 2024
Full Text: View/download PDF

14. A new hybrid gadolinium nanoparticles-loaded polymeric material for neutron detection in rare event searches

Author: Collaboration, DarkSide-20k, Acerbi, F., Adhikari, P., Agnes, P., Ahmad, I., Albergo, S., Albuquerque, I. F., Alexander, T., Alton, A. K., Amaudruz, P., Angiolilli, M., Aprile, E., Ardito, R., Corona, M. Atzori, Auty, D. J., Ave, M., Avetisov, I. C., Azzolini, O., Back, H. O., Balmforth, Z., Olmedo, A. Barrado, Barrillon, P., Batignani, G., Bhowmick, P., Bocci, V., Bonivento, W., Bottino, B., Boulay, M. G., Buchowicz, A., Bussino, S., Busto, J., Cadeddu, M., Cadoni, M., Calabrese, R., Camillo, V., Caminata, A., Canci, N., Capra, A., Caravati, M., Cárdenas-Montes, M., Cargioli, N., Carlini, M., Castellani, A., Castello, P., Cavalcante, P., Cavallo, D., Cebrian, S., Ruiz, J. Cela, Chashin, S., Chepurnov, A., Cifarelli, L., Cintas, D., Citterio, M., Cleveland, B., Coadou, Y., Cocco, V., Colaiuda, D., Vilda, E. Conde, Consiglio, L., Costa, B. S., Czubak, M., D'Auria, S., Rolo, M. D. Da Rocha, Darbo, G., Davini, S., De Cecco, S., De Guido, G., Dellacasa, G., Derbin, A. V., Devoto, A., Di Capua, F., Di Ludovico, A., Di Noto, L., Di Stefano, P., Dias, L. K., Mairena, D. Díaz, Ding, X., Dionisi, C., Dolganov, G., Dordei, F., Dronik, V., Elersich, A., Ellingwood, E., Erjavec, T., Diaz, M. Fernandez, Ficorella, A., Fiorillo, G., Franchini, P., Franco, D., Gatti, H. Frandini, Frolov, E., Gabriele, F., Gahan, D., Galbiati, C., Galinski, G., Gallina, G., Garbini, M., Abia, P. Garcia, Gawdzik, A., Gendotti, A., Ghisi, A., Giovanetti, G. K., Casanueva, V. Goicoechea, Gola, A., Grandi, L., Grauso, G., di Cortona, G. Grilli, Grobov, A., Gromov, M., Guerzoni, M., Gulino, M., Guo, C., Hackett, B. R., Hallin, A., Hamer, A., Haranczyk, M., Harrop, B., Hessel, T., Hill, S., Horikawa, S., Hu, J., Hubaut, F., Hucker, J., Hugues, T., Hungerford, E. V., Ianni, A., Ippolito, V., Jamil, A., Jillings, C., Keloth, R., Kemmerich, N., Kemp, A., Kendziora, C. L., Kimura, M., Kondo, K., Korga, G., Kotsiopoulou, L., Koulosousas, S., Kubankin, A., Kuss, M., Kuzniak, M., Kuzwa, M., La Commara, M., Lai, M., Guirriec, E. Le, Leason, E., Leoni, A., Lidey, L., Lissia, M., Luzzi, L., Lychagina, O., Macfadyen, O., Machulin, I. N., Manecki, S., Manthos, I., Mapelli, L., Marasciulli, A., Mari, S. M., Mariani, C., Maricic, J., Marini, A., Martinez, M., Martoff, C. J., Matteucci, G., Mavrokoridis, K., McDonald, A. B., Mclaughlin, J., Merzi, S., Messina, A., Milincic, R., Minutoli, S., Mitra, A., Moharana, A., Moioli, S., Monroe, J., Moretti, E., Morrocchi, M., Mroz, T., Muratova, V. N., Murphy, M., Murra, M., Muscas, C., Musico, P., Nania, R., Nessi, M., Nieradka, G., Nikolopoulos, K., Nikoloudaki, E., Nowak, J., Olchanski, K., Oleinik, A., Oleynikov, V., Organtini, P., de Solórzano, A. Ortiz, Pallavicini, M., Pandola, L., Pantic, E., Paoloni, E., Papi, D., Pastuszak, G., Paternoster, G., Peddis, D., Pegoraro, P. A., Pelczar, K., Pellegrini, L. A., Perez, R., Perotti, F., Pesudo, V., Piacentini, S. I., Pino, N., Plante, G., Pocar, A., Poehlmann, M., Pordes, S., Pralavorio, P., Price, D., Puglia, S., Bazetto, M. Queiroga, Ragusa, F., Ramachers, Y., Ramirez, A., Ravinthiran, S., Razeti, M., Renshaw, A. L., Rescigno, M., Retiere, F., Rignanese, L. P., Rivetti, A., Roberts, A., Roberts, C., Rogers, G., Romero, L., Rossi, M., Rubbia, A., Rudik, D., Sabia, M., Sadashivajois, S., Salomone, P., Samoylov, O., Sandford, E., Sanfilippo, S., Santone, D., Santorelli, R., Santos, E. M., Savarese, C., Scapparone, E., Schillaci, G., Schuckman II, F. G., Scioli, G., Semenov, D. A., Sheshukov, A., Simeone, M., Skensved, P., Skorokhvatov, M. D., Slimani, S., Smirnov, O., Smirnova, T., Smith, B., Sotnikov, A., Spadoni, F., Spangenberg, M., Stefanizzi, R., Steri, A., Stornelli, V., Stracka, S., Sulis, S., Sung, A., Sunny, C., Suvorov, Y., Szelc, A. M., Taborda, O., Tartaglia, R., Taylor, A., Taylor, J., Tedesco, S., Testera, G., Thieme, K., Thompson, A., Tonazzo, A., Torres-Lara, S., Tosi, S., Tricomi, A., Unzhakov, E. V., Vallivilayil, T. J., Van Uffelen, M., Velazquez-Fernandez, L., Viant, T., Vicini, S., Viel, S., Vishneva, A., Vogelaar, R. B., Vossebeld, J., Vyas, B., Wada, M., Walczak, M. B., Wang, H., Wang, Y., Westerdale, S., Williams, L., Wojaczynski, R., Wojcik, M. M., Wojcik, M., Wright, T., Xie, Y., Yang, C., Yin, J., Zabihi, A., Zakhary, P., Zani, A., Zhang, Y., Zhu, T., Zichichi, A., Zuzel, G., and Zykova, M. P.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: Experiments aimed at direct searches for WIMP dark matter require highly effective reduction of backgrounds and control of any residual radioactive contamination. In particular, neutrons interacting with atomic nuclei represent an important class of backgrounds due to the expected similarity of a WIMP-nucleon interaction, so that such experiments often feature a dedicated neutron detector surrounding the active target volume. In the context of the development of DarkSide-20k detector at INFN Gran Sasso National Laboratory (LNGS), several R&D projects were conceived and developed for the creation of a new hybrid material rich in both hydrogen and gadolinium nuclei to be employed as an essential element of the neutron detector. Thanks to its very high cross-section for neutron capture, gadolinium is one of the most widely used elements in neutron detectors, while the hydrogen-rich material is instrumental in efficiently moderating the neutrons. In this paper results from one of the R&Ds are presented. In this effort the new hybrid material was obtained as a poly(methyl methacrylate) (PMMA) matrix, loaded with gadolinium oxide in the form of nanoparticles. We describe its realization, including all phases of design, purification, construction, characterization, and determination of mechanical properties of the new material.
Published: 2024
Full Text: View/download PDF

15. Successful pregnancy after uterine artery embolization for uterine arterovenous malformation: a rare case report

Author: Guida M, Maffucci D, Iannuzzi G, Giordano M, Luciano G, Di Benedetto L, Cantarella R, Rescigno A, and Giugliano L
Subjects: Uterine artery embolization, fertility, uterine arteriovenous malformation, pregnancy, angiography, Gynecology and obstetrics, RG1-991
Abstract: M Guida,1 D Maffucci,1 G Iannuzzi,1 M Giordano,1 G Luciano,1 L Di Benedetto,2 R Cantarella,3 A Rescigno,3 L Giugliano1 1Università degli studi di Salerno – Dipartimento di Medicina, Chirurgia e Odontoiatria “Scuola Medica Salernitana”, Salerno, Italy; 2Università degli studi di Roma “La Sapienza” – Dipartimento di Scienze Medico-Chirurgiche e di Medicina Traslazionale – Facoltà di Medicina e Psicologia Azienda Ospedaliera Sant’ Andrea, Rome, Italy; 3Azienda Ospedaliera Universitaria San Giovanni di Dio e Ruggi D’Aragona, Salerno, Italy Objective: This paper reports on a rare case of pregnancy after uterine artery embolization (UAE) for uterine arteriovenous malformation (AVM). Debate exists about persistence of fertility in women after UAE. Adverse effects of this technique can modify both uterine echostructure, inducing necrosis and infarction, endometrial atrophy and uterine artery rupture, and ovarian reserve, causing persistent amenorrhea. Ovarian reserve appears to be affected by UAE in premenopausal women. However, younger ovaries (according to biological ovarian age) exhibit a greater capacity for recovery after ovarian damage. Therefore, larger studies are needed for more conclusive results. Case report: A 28-year-old woman was admitted to our department due to life-threatening uterine bleeding, resulting in tachycardia, pallor, and sweating. The patient came with a history of two spontaneous miscarriages. After sonography and computed tomography, AVMs were identified at uterine fundus and anterior wall. Conclusion: The pathogenesis of infertility after UAE is not yet known. The peculiarity of this case was that, only few months later, the patient became pregnant and gave birth to a live fetus at 37 weeks with cesarean delivery. Keywords: uterine artery embolization, fertility, uterine arteriovenous malformation, pregnancy, angiography
Published: 2018

16. Models of Accidental Dark Matter with a Fundamental Scalar

Author: Palmisano, Stefano, Rescigno, Francesco, and Troni, Federica
Subjects: High Energy Physics - Phenomenology
Abstract: We consider models of accidental dark matter, namely models in which the dark matter is a composite state that is stable thanks to an accidental symmetry of the theory. The fundamental constituents are vectorlike fermions, taken to be fragments of representations of the grand unifying gauge group $SU(5)$, as well as a scalar singlet. All the new fields are charged under a new confining gauge group, which we take to be $SU(N)$, leading to models with complex dark matter. We analyse the models in the context of $SU(5)$ grand unification with a non-standard approach recently proposed in the literature. The advantage of including the scalar mainly resides in the fact that it allows several undesired accidental symmetries to be broken, leading to a larger set of viable models with respect to previous literature, in which only fermions (or only scalars) were considered. Moreover these models present distinct novelties, namely dark states with non-zero baryon and lepton number and the existence of composite hybrid states of fermions and scalars. We identify phenomena that are specific to the inclusion of the scalar and discuss possibilities to test this setup., Comment: 27 pages + appendices
Published: 2024

17. Attosecond X-ray Chronoscopy of Core-level Photoemission

Author: Ji, Jia-Bao, Guo, Zhaoheng, Driver, Taran, Trevisan, Cynthia S., Cesar, David, Cheng, Xinxin, Duris, Joseph, Franz, Paris L., Glownia, James, Gong, Xiaochun, Hammerland, Daniel, Han, Meng, Heck, Saijoscha, Hoffmann, Matthias, Kamalov, Andrei, Larsen, Kirk A., Li, Xiang, Lin, Ming-Fu, Liu, Yuchen, McCurdy, C. William, Obaid, Razib, ONeal, Jordan T., Rescigno, Thomas N., Robles, River R., Sudar, Nicholas, Walter, Peter, Wang, Anna L., Wang, Jun, Wolf, Thomas J. A., Zhang, Zhen, Ueda, Kiyoshi, Lucchese, Robert R., Marinelli, Agostino, Cryan, James P., and Wörner, Hans Jakob
Subjects: Physics - Chemical Physics
Abstract: Attosecond photoemission or photoionization delays are a unique probe of the structure and the electronic dynamics of matter. However, spectral congestion and spatial delocalization of valence electron wave functions set fundamental limits to the complexity of systems that can be studied and the information that can be retrieved, respectively. Using attosecond X-ray pulses from LCLS, we demonstrate the key advantages of measuring core-level delays: the photoelectron spectra remain atom-like, the measurements become element specific and the observed scattering dynamics originate from a point-like source. We exploit these unique features to reveal the effects of electronegativity and symmetry on attosecond scattering dynamics by measuring the photoionization delays between N-1s and C-1s core shells of a series of aromatic azabenzene molecules. Remarkably, the delays systematically increase with the number of nitrogen atoms in the molecule and reveal multiple resonances. We identify two previously unknown mechanisms regulating the associated attosecond dynamics, namely the enhanced confinement of the trapped wavefunction with increasing electronegativity of the atoms and the decrease of the coupling strength among the photoemitted partial waves with increasing symmetry. This study demonstrates the unique opportunities opened by measurements of core-level photoionization delays for unravelling attosecond electron dynamics in complex matter.
Published: 2024

18. The first quenched galaxies, when and how?

Author: Xie, Lizhi, De Lucia, Gabriella, Fontanot, Fabio, Hirschmann, Michaela, Bahé, Yannick M, Balogh, Michael L., Muzzin, Adam, Vulcani, Benedetta, Baxter, Devontae C., Forrest, Ben, Wilson, Gillian, Rudnick, Gregory H., Cooper, M. C., and Rescigno, Umberto
Subjects: Astrophysics - Astrophysics of Galaxies
Abstract: Many quiescent galaxies discovered in the early Universe by \textit{JWST} raise fundamental questions on when and how these galaxies became and stayed quenched. Making use of the latest version of the semi-analytic model GAEA that provides good agreement with the observed quenched fractions up to $z\sim 3$, we make predictions for the expected fractions of quiescent galaxies up to $z\sim 7$ and analyze the main quenching mechanism. We find that in a simulated box of $685~{\rm Mpc}$ on a side, the first quenched massive ($M_{\star} \sim 10^{11} {\rm M}_{\odot}$), Milky Way mass, and low mass ($M_{\star} \sim 10^{9.5} {\rm M}_{\odot}$ ) galaxies appear at $z\sim 4.5$, $z\sim 6.2$, and before $z = 7$. Most quenched galaxies identified at early redshifts remain quenched for more than 1 Gyr. Independently of galaxy stellar mass, the dominant quenching mechanism at high redshift is accretion disk feedback (quasar winds) from a central massive black hole, which is triggered by mergers in massive and MW-mass galaxies, and by disk instabilities in low-mass galaxies. Environmental stripping becomes increasingly more important at lower redshift., Comment: 8 pages, 3 figures, Accepted publication in APJL
Published: 2024

19. Long-term temporal stability of the DarkSide-50 dark matter detector

Author: Collaboration, The DarkSide-50, Agnes, P., Albuquerque, I. F. M., Alexander, T., Alton, A. K., Ave, M., Back, H. O., Batignani, G., Biery, K., Bocci, V., Bonivento, W. M., Bottino, B., Bussino, S., Cadeddu, M., Cadoni, M., Calaprice, F., Caminata, A., Campos, M. D., Canci, N., Caravati, M., Cargioli, N., Cariello, M., Carlini, M., Cataudella, V., Cavalcante, P., Cavuoti, S., Chashin, S., Chepurnov, A., Cicalò, C., Covone, G., D'Angelo, D., Davini, S., De Candia, A., De Cecco, S., De Filippis, G., De Rosa, G., Derbin, A. V., Devoto, A., D'Incecco, M., Dionisi, C., Dordei, F., Downing, M., D'Urso, D., Fairbairn, M., Fiorillo, G., Franco, D., Gabriele, F., Galbiati, C., Ghiano, C., Giganti, C., Giovanetti, G. K., Goretti, A. M., di Cortona, G. Grilli, Grobov, A., Gromov, M., Guan, M., Gulino, M., Hackett, B. R., Herner, K., Hessel, T., Hosseini, B., Hubaut, F., Hugues, T., Hungerford, E. V., Ianni, An., Ippolito, V., Keeter, K., Kendziora, C. L., Kimura, M., Kochanek, I., Korablev, D., Korga, G., Kubankin, A., Kuss, M., Kuźniak, M., La Commara, M., Lai, M., Li, X., Lissia, M., Longo, G., Lychagina, O., Machulin, I. N., Mapelli, L. P., Mari, S. M., Maricic, J., Messina, A., Milincic, R., Monroe, J., Morrocchi, M., Mougeot, X., Muratova, V. N., Musico, P., Nozdrina, A. O., Oleinik, A., Ortica, F., Pagani, L., Pallavicini, M., Pandola, L., Pantic, E., Paoloni, E., Pelczar, K., Pelliccia, N., Piacentini, S., Pocar, A., Poehlmann, D. M., Pordes, S., Poudel, S. S., Pralavorio, P., Price, D. D., Ragusa, F., Razeti, M., Razeto, A., Renshaw, A. L., Rescigno, M., Rode, J., Romani, A., Sablone, D., Samoylov, O., Sandford, E., Sands, W., Sanfilippo, S., Savarese, C., Schlitzer, B., Semenov, D. A., Shchagin, A., Sheshukov, A., Skorokhvatov, M. D., Smirnov, O., Sotnikov, A., Stracka, S., Suvorov, Y., Tartaglia, R., Testera, G., Tonazzo, A., Unzhakov, E. V., Vishneva, A., Vogelaar, R. B., Wada, M., Wang, H., Wang, Y., Westerdale, S., Wojcik, M. M., Xiao, X., Yang, C., and Zuzel, G.
Subjects: High Energy Physics - Experiment, Astrophysics - Cosmology and Nongalactic Astrophysics, Physics - Instrumentation and Detectors
Abstract: The stability of a dark matter detector on the timescale of a few years is a key requirement due to the large exposure needed to achieve a competitive sensitivity. It is especially crucial to enable the detector to potentially detect any annual event rate modulation, an expected dark matter signature. In this work, we present the performance history of the DarkSide-50 dual-phase argon time projection chamber over its almost three-year low-radioactivity argon run. In particular, we focus on the electroluminescence signal that enables sensitivity to sub-keV energy depositions. The stability of the electroluminescence yield is found to be better than 0.5%. Finally, we show the temporal evolution of the observed event rate around the sub-keV region being consistent to the background prediction., Comment: 13 pages, 5 figures
Published: 2023
Full Text: View/download PDF

20. A hot mini-Neptune and a temperate, highly eccentric sub-Saturn around the bright K-dwarf TOI-2134

Author: Rescigno, F., Hébrard, G., Vanderburg, A., Mann, A. W., Mortier, A., Morrell, S., Buchhave, L. A., Collins, K. A., Mann, C. R., Hellier, C., Haywood, R. D., West, R., Stalport, M., Heidari, N., Anderson, D., Huang, C. X., López-Morales, M., Cortés-Zuleta, P., Lewis, H. M., Dumusque, X., Boisse, I., Rowden, P., Cameron, A. Collier, Deleuil, M., Vezie, M., Pepe, F. A., Delfosse, X., Charbonneau, D., Rice, K., Demangeon, O., Quinn, S. N., Udry, S., Forveille, T., Winn, J. N., Sozzetti, A., Hoyer, S., Seager, S., Wilson, T. G., Dalal, S., Martioli, E., Striegel, S., Boschin, W., Dragomir, D., Fiorenzano, A. F. Martínez, Cosentino, R., Ghedina, A., Malavolta, L., Affer, L., Lakeland, B. S., Nicholson, B. A., Foschino, S., Wünsche, A., Barkaoui, K., Srdoc, G., Randolph, J., Guillet, B., Conti, D. M., Ghachoui, M., Gillon, M., Benkhaldoun, Z., Pozuelos, F. J., Timmermans, M., Girardin, E., Matutano, S., Bosch-Cabot, P., Muñoz, J. A., and Forés-Toribio, R.
Subjects: Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Solar and Stellar Astrophysics
Abstract: We present the characterisation of an inner mini-Neptune in a 9.2292005$\pm$0.0000063 day orbit and an outer mono-transiting sub-Saturn planet in a 95.50$^{+0.36}_{-0.25}$ day orbit around the moderately active, bright (mv=8.9 mag) K5V star TOI-2134. Based on our analysis of five sectors of TESS data, we determine the radii of TOI-2134b and c to be 2.69$\pm$0.16 R$_{e}$ for the inner planet and 7.27$\pm$0.42 R$_{e}$ for the outer one. We acquired 111 radial-velocity spectra with HARPS-N and 108 radial-velocity spectra with SOPHIE. After careful periodogram analysis, we derive masses for both planets via Gaussian Process regression: 9.13$^{+0.78}_{-0.76}$ M$_{e}$ for TOI-2134b and 41.86$^{+7.69}_{-7.83}$ M$_{e}$ for TOI-2134c. We analysed the photometric and radial-velocity data first separately, then jointly. The inner planet is a mini-Neptune with density consistent with either a water-world or a rocky core planet with a low-mass H/He envelope. The outer planet has a bulk density similar to Saturn's. The outer planet is derived to have a significant eccentricity of 0.67$^{+0.05}_{-0.06}$ from a combination of photometry and RVs. We compute the irradiation of TOI-2134c as 1.45$\pm$0.10 times the bolometric flux received by Earth, positioning it for part of its orbit in the habitable sone of its system. We recommend further RV observations to fully constrain the orbit of TOI-2134c. With an expected Rossiter-McLaughlin (RM) effect amplitude of 7.2$\pm$1.3 m/s, we recommend TOI-2134c for follow-up RM analysis to study the spin-orbit architecture of the system. We calculate the Transmission Spectroscopy Metric, and both planets are suitable for bright-mode NIRCam atmospheric characterisation., Comment: 24 pages, 7 tables, 14 figures
Published: 2023
Full Text: View/download PDF

21. Masses, Revised Radii, and a Third Planet Candidate in the 'Inverted' Planetary System Around TOI-1266

Author: Cloutier, Ryan, Greklek-McKeon, Michael, Wurmser, Serena, Cherubim, Collin, Gillis, Erik, Vanderburg, Andrew, Hadden, Sam, Cadieux, Charles, Artigau, Étienne, Vissapragada, Shreyas, Mortier, Annelies, López-Morales, Mercedes, Latham, David W., Knutson, Heather, Haywood, Raphaëlle D., Pallé, Enric, Doyon, René, Cook, Neil, Andreuzzi, Gloria, Cecconi, Massimo, Cosentino, Rosario, Ghedina, Adriano, Harutyunyan, Avet, Pinamonti, Matteo, Stalport, Manu, Damasso, Mario, Rescigno, Federica, Wilson, Thomas G., Buchhave, Lars A., Charbonneau, David, Cameron, Andrew Collier, Dumusque, Xavier, Lovis, Christophe, Mayor, Michel, Molinari, Emilio, Pepe, Francesco, Piotto, Giampaolo, Rice, Ken, Sasselov, Dimitar, Ségransan, Damien, Sozzetti, Alessandro, Udry, Stéphane, and Watson, Chris A.
Subjects: Astrophysics - Earth and Planetary Astrophysics
Abstract: Is the population of close-in planets orbiting M dwarfs sculpted by thermally driven escape or is it a direct outcome of the planet formation process? A number of recent empirical results strongly suggest the latter. However, the unique architecture of the TOI-1266 system presents a challenge to models of planet formation and atmospheric escape given its seemingly "inverted" architecture of a large sub-Neptune ($P_b=10.9$ days, $R_{p,b}=2.62\pm 0.11\, \mathrm{R}_{\oplus}$) orbiting interior to that of the system's smaller planet ($P_c=18.8$ days, $R_{p,c}=2.13\pm 0.12\, \mathrm{R}_{\oplus}$). Here we present revised planetary radii based on new TESS and diffuser-assisted ground-based transit observations, and characterize both planetary masses using a set of 145 radial velocity measurements from HARPS-N ($M_{p,b}=4.23\pm 0.69\, \mathrm{M}_{\oplus}, M_{p,c}=2.88\pm 0.80\, \mathrm{M}_{\oplus}$). Our analysis also reveals a third planet candidate ($P_d=32.3$ days, $M_{p,d}\sin{i} = 4.59^{+0.96}_{-0.94}\, \mathrm{M}_{\oplus}$), which if real, would form a chain of near 5:3 period ratios, although the system is likely not in a mean motion resonance. Our results indicate that TOI-1266 b and c are among the lowest density sub-Neptunes around M dwarfs and likely exhibit distinct bulk compositions of a gas-enveloped terrestrial ($X_{\mathrm{env},b}=5.5\pm 0.7$%) and a water-rich world (WMF$_c=59\pm 14$%), which is supported by hydrodynamic escape models. If distinct bulk compositions are confirmed through atmospheric characterization, the system's unique architecture would represent an interesting test case of inside-out sub-Neptune formation at pebble traps., Comment: Accepted for publication in MNRAS. 21 pages. Our spectroscopic time series are included in the arXiv source files as table6.csv
Published: 2023

22. Radiotherapy plus pembrolizumab for advanced urothelial carcinoma: results from the ARON-2 real-world study

Author: Rizzo, Mimma, Soares, Andrey, Grande, Enrique, Bamias, Aristotelis, Kopp, Ray Manneh, Lenci, Edoardo, Buttner, Thomas, Salah, Samer, Grillone, Francesco, de Carvalho, Icaro Thiago, Tapia, Jose Carlos, Gucciardino, Calogero, Pinto, Alvaro, Mennitto, Alessia, Abahssain, Halima, Rescigno, Pasquale, Myint, Zin, Takeshita, Hideki, Spinelli, Gian Paolo, Popovic, Lazar, Vitale, Maria Giuseppa, Fiala, Ondrej, Giannatempo, Patrizia, Zakopoulou, Roubini, Carrozza, Francesco, Massari, Francesco, Monteiro, Fernando Sabino Marques, Pace, Maria Paola, Giannini, Massimo, Roviello, Giandomenico, Porta, Camillo, Battelli, Nicola, Kanesvaran, Ravindran, and Santoni, Matteo
Published: 2024
Full Text: View/download PDF

23. International multicenter real-world REGistry for patients with metastatic renAL cell carcinoma – Meet-URO 33 study (REGAL study)

Author: Rebuzzi, Sara Elena, Fornarini, Giuseppe, Signori, Alessio, Buti, Sebastiano, Procopio, Giuseppe, De Giorgi, Ugo, Pignata, Sandro, Naglieri, Emanuele, Maruzzo, Marco, Banna, Giuseppe Luigi, Rescigno, Pasquale, Messina, Carlo, Mattana, Alvise, Basso, Umberto, and Bimbatti, Davide
Published: 2024
Full Text: View/download PDF

24. Microbial composition associated with biliary stents in patients undergoing pancreatic resection for cancer

Author: Blanco-Míguez, Aitor, Carloni, Sara, Cardenas, Cindy, Dioguardi, Carola Conca, Lambroia, Luca, Capretti, Giovanni, Nappo, Gennaro, Fugazza, Alessandro, Capogreco, Antonio, Armanini, Federica, Asnicar, Francesco, Dubois, Leonard, Golzato, Davide, Manghi, Paolo, Pinto, Federica, Scuderi, Cristina, Casari, Erminia, Montorsi, Marco, Anderloni, Andrea, Rescigno, Maria, Repici, Alessandro, Zerbi, Alessandro, Peano, Clelia, Tamburini, Sabrina, Rusconi, Roberto, and Segata, Nicola
Published: 2024
Full Text: View/download PDF

25. Instrumental activities of daily living in older patients with metastatic prostate cancer: results from the meet-URO network ADHERE prospective study

Author: Fratino, Lucia, Polesel, Jerry, Giunta, Emilio Francesco, Maruzzo, Marco, Buti, Sebastiano, Hassan, Mona Ali, Basso, Umberto, Rebuzzi, Sara Elena, De Giorgi, Ugo, Cinausero, Marika, Lipari, Helga, Gamba, Teresa, Bimbatti, Davide, Dri, Arianna, Ermacora, Paola, Vignani, Francesca, Fornarini, Giuseppe, Rescigno, Pasquale, and Banna, Giuseppe Luigi
Published: 2024
Full Text: View/download PDF

26. Association of vaccine status, reinfections, and risk factors with Long COVID syndrome

Author: Romero-Ibarguengoitia, Maria Elena, Rodríguez-Torres, Juan Francisco, Garza-Silva, Arnulfo, Rivera-Cavazos, Andrea, Morales-Rodriguez, Devany Paola, Hurtado-Cabrera, Mauricio, Kalife-Assad, Ricardo, Villarreal-Parra, Diana, Loose-Esparza, Alejandro, Gutiérrez-Arias, Juan José, Mata-Porras, Yaressi Guadalupe, Ojeda-Salazar, Daniela Abigail, Sanz-Sánchez, Miguel Angel, González-Cantú, Arnulfo, Azzolini, Elena, and Rescigno, Maria
Published: 2024
Full Text: View/download PDF

27. Native intra-articular knee microbiome is a matter of facts: a systematic review of clinical evidence

Author: Tommaso Bonanzinga, Pietro Conte, Giuseppe Anzillotti, Vincenzo Longobardi, Elizaveta Kon, Maria Rescigno, and Maurilio Marcacci
Subjects: intraarticular, joint, knee, microbiome, microbiota, osteoarthritis, Orthopedic surgery, RD701-811
Abstract: Purpose: Growing interest surrounds the role of human gut microbiome in the development of degenerative pathologies such as osteoarthritis (OA), but microbes have recently been detected also in other sites previously considered to be sterile. Evidence emerged suggesting that even native and osteoarthritic knee joints may host several microbial species possibly involved in the osteoarthritic degeneration. This is the first systematic review critically collecting all the available evidence on the existence and composition of knee intra-articular microbiome. Methods: A systematic research on the PubMed, Cochrane and Google Scholar databases was performed. Human clinical studies investigating the presence of intra-articular microbiome in native osteoarthritic knee joints with next-generation sequencing techniques were collected. Results: A total of eight studies were included reporting data on 255 knees. All the included studies reported evidence supporting the existence of an intra-articular microbiome in native knee joints, with detection rates varying from 5.8% to 100%. Bacteria from the Proteobacteria phylum were found to be among the most identified followed by the Actinobacteria, Firmicutes, Fusobacteria, and Bacteroideta phyla. Proteobacteria phylum were also found to be more common in osteoarthritic knees when compared to healthy joints. Furthermore, several pathways correlating those microbes to knee OA progression have been suggested and summarized in this review. Conclusions: Evidence collected in this systematic review suggests that the native knee joint, previously presumed to be a sterile environment, hosts a peculiar intra-articular microbiome with a unique composition. Furthermore, its alteration may have a link with the progression of knee osteoarthritis.
Published: 2024
Full Text: View/download PDF

28. Biological Activities and Nutraceutical Potentials of Water Extracts from Different Parts of Cynomorium Coccineum L. (Maltese Mushroom)

Author: Zucca Paolo, Argiolas Antonio, Nieddu Mariella, Pintus Manuela, Rosa Antonella, Sanna Fabrizio, Steri Daniela, and Rescigno Antonio
Subjects: functional food, nutraceuticals, Cynomorium coccineum, Maltese Mushroom, tarthuth, B16F10 melanoma cells, Nutrition. Foods and food supply, TX341-641
Abstract: Maltese Mushroom (Cynomorium coccineum L.) is a non-photosynthetic plant that has been used in traditional medicine for many centuries. In this paper, water extracts from the whole plant, external layer and peeled plant were studied to determine the main components responsible for its biological activities, i.e., its antimicrobial, antioxidant, and anti-tyrosinase activities; its cytotoxicity against mouse melanoma B16F10 cells; and its pro-erectile activity in adult male rats. The results of electron transfer and hydrogen transfer assays showed that the antioxidant activity was mainly due to anthocyanins in the external layer, whereas the external layer and peeled plant extracts both inhibited the microbial growth of several Gram-positive strains. In contrast, the whole plant extract had the highest anti-tyrosinase activity and exhibited pro-erectile activity when administered subcutaneously. Overall, this study elucidated which parts of Maltese Mushroom are responsible for its antimicrobial, antioxidant, and anti-tyrosinase activities and thus which extracts have potential for use in nutraceutical formulations.
Published: 2016
Full Text: View/download PDF

29. Outflowing helium from a mature mini-Neptune

Author: Zhang, Michael, Dai, Fei, Bean, Jacob L., Knutson, Heather A., and Rescigno, Federica
Subjects: Astrophysics - Earth and Planetary Astrophysics
Abstract: We announce the detection of escaping helium from TOI 2134b, a mini-Neptune a few Gyr old. The average in-transit absorption spectrum shows a peak of 0.37 +- 0.05% and an equivalent width of $W_{\rm avg}=3.3 \pm 0.3$ m$\r{A}$. Among all planets with helium detections, TOI 2134b is the only mature mini-Neptune, has the smallest helium signal, and experiences the lowest XUV flux. Putting TOI 2134b in the context of all other helium detections, we report the detection of a strong (p=3.0e-5) and theoretically expected correlation between $F_{\rm XUV}/\rho_{\rm XUV}$ (proportional to the energy-limited mass loss rate) and $R_* W_{\rm avg}$ (roughly proportional to the observationally inferred mass loss rate). Here, $W_{\rm avg}$ is the equivalent width of the helium absorption and $\rho_{\rm XUV}$ is the density of the planet within the XUV photosphere, but the correlation is similarly strong if we use the optical photosphere. TOI 2134b anchors the relation, having the lowest value on both axes. We encourage further observations to fill in missing regions of this parameter space and improve estimates of $F_{\rm XUV}$., Comment: Accepted by ApJL
Published: 2023

30. Directionality of nuclear recoils in a liquid argon time projection chamber

Author: Collaboration, The DarkSide-20k, Agnes, P., Ahmad, I., Albergo, S., Albuquerque, I. F. M., Alexander, T., Alton, A. K., Amaudruz, P., Corona, M. Atzori, Ave, M., Avetisov, I. Ch., Azzolini, O., Back, H. O., Balmforth, Z., Barrado-Olmedo, A., Barrillon, P., Basco, A., Batignani, G., Bocci, V., Bonivento, W. M., Bottino, B., Boulay, M. G., Busto, J., Cadeddu, M., Caminata, A., Canci, N., Cappello, G., Capra, A., Caprioli, S., Caravati, M., Cargioli, N., Carlini, M., Castello, P., Cataudella, V., Cavalcante, P., Cavuoti, S., Cebrian, S., Ruiz, J. M. Cela, Chashin, S., Chepurnov, A., Chyhyrynets, E., Cifarelli, L., Cintas, D., Citterio, M., Cleveland, B., Cocco, V., Vilda, E. Conde, Consiglio, L., Copello, S., Covone, G., Czubak, M., D'Aniello, M., D'Auria, S., Rolo, M. D. Da Rocha, Davini, S., de Candia, A., De Cecco, S., De Gruttola, D., De Filippis, G., Dell'Aquila, D., De Pasquale, S., De Rosa, G., Dellacasa, G., Derbin, A. V., Devoto, A., Di Capua, F., Di Noto, L., Dionisi, C., Di Stefano, P., Dolganov, G., Dordei, F., Elersich, A., Ellingwood, E., Erjavec, T., Diaz, M. Fernandez, Fiorillo, G., Franchini, P., Franco, D., Funicello, N., Gabriele, F., Gahan, D., Galbiati, C., Gallina, G., Gallus, G., Garbini, M., Abia, P. Garcia, Gendotti, A., Ghiano, C., Giganti, C., Giovanetti, G. K., Casanueva, V. Goicoechea, Gola, A., Grauso, G., di Cortona, G. Grilli, Grobov, A., Gromov, M., Guan, M., Guerzoni, M., Gulino, M., Guo, C., Hackett, B. R., Hallin, A. L., Hamer, A., Haranczyk, M., Hessel, T., Hill, S., Horikawa, S., Hubaut, F., Hucker, J., Hugues, T., Ianni, An., Ippolito, V., Jillings, C., Jois, S., Kachru, P., Kemmerich, N., Kemp, A. A., Kendziora, C. L., Kimura, M., Kochanek, I., Kondo, K., Korga, G., Koulosousas, S., Kubankin, A., Kuss, M., Kuzniak, M., La Commara, M., Lai, M., Guirriec, E. Le, Leason, E., Leoni, A., Li, X., Lidey, L., Lissia, M., Luzzi, L., Lychagina, O., Macfadyen, O., Machulin, I. N., Manecki, S., Manthos, I., Mapelli, L., Margotti, A., Marik, S. M., Mariani, C., Maricic, J., Marini, A., Martínez, M., Martoff, C. J., Matteucci, G., Mavrokoridis, K., McDonald, A. B., Messina, A., Milincic, R., Mitra, A., Moharana, A., Monroe, J., Moretti, E., Morrocchi, M., Mróz, T., Muratova, V. N., Muscas, C., Musico, P., Nania, R., Nessi, M., Nieradka, G., Nikolopoulos, K., Nowak, J., Olchansky, K., Oleinik, A., Oleynikov, V., Organtini, P., de Solórzano, A. Ortiz, Pagani, L., Pallavicini, M., Pandola, L., Pantic, E., Paoloni, E., Paternoster, G., Pegoraro, P. A., Pelczar, K., Pesudo, V., Piacentini, S., Pino, N., Pocar, A., Poehlmann, D. M., Pordes, S., Pralavorio, P., Price, D., Ragusa, F., Ramachers, Y., Razeti, M., Renshaw, A. L., Rescigno, M., Retiere, F., Rignanese, L. P., Ripoli, C., Rivetti, A., Roberts, A., Roberts, C., Rode, J., Rogers, G., Romero, L., Rossi, M., Rubbia, A., Sabia, M. A., Salomone, P., Sandford, E., Sanfilippo, S., Santone, D., Santorelli, R., Savarese, C., Scapparone, E., Schillaci, G., Schuckman II, F. G., Scioli, G., Simeone, M., Skensved, P., Skorokhvatov, M. D., Smirnov, O., Smirnova, T., Smith, B., Sosa, A., Spadoni, F., Spangenberg, M., Stefanizzi, R., Steri, A., Stornelli, V., Stracka, S., Stringer, M., Sulis, S., Sung, A., Suvorov, Y., Szelc, A. M., Tartaglia, R., Taylor, A., Taylor, J., Tedesco, S., Testera, G., Thieme, K., Thorpe, T. N., Tonazzo, A., Tricomi, A., Unzhakov, E. V., John, T. Vallivilayil, Van Uffelen, M., Viant, T., Viel, S., Vogelaar, R. B., Vossebeld, J., Wada, M., Walczak, M. B., Wang, H., Wang, Y., Westerdale, S., Williams, L., Wingerter-Seez, I., Wojaczynski, R., Wojcik, Ma. M., Wright, T., Xie, Y., Yang, C., Zabihi, A., Zakhary, P., Zani, A., Zichichi, A., Zuzel, G., and Zykova, M. P.
Subjects: Physics - Instrumentation and Detectors
Abstract: The direct search for dark matter in the form of weakly interacting massive particles (WIMP) is performed by detecting nuclear recoils (NR) produced in a target material from the WIMP elastic scattering. A promising experimental strategy for direct dark matter search employs argon dual-phase time projection chambers (TPC). One of the advantages of the TPC is the capability to detect both the scintillation and charge signals produced by NRs. Furthermore, the existence of a drift electric field in the TPC breaks the rotational symmetry: the angle between the drift field and the momentum of the recoiling nucleus can potentially affect the charge recombination probability in liquid argon and then the relative balance between the two signal channels. This fact could make the detector sensitive to the directionality of the WIMP-induced signal, enabling unmistakable annual and daily modulation signatures for future searches aiming for discovery. The Recoil Directionality (ReD) experiment was designed to probe for such directional sensitivity. The TPC of ReD was irradiated with neutrons at the INFN Laboratori Nazionali del Sud, and data were taken with 72 keV NRs of known recoil directions. The direction-dependent liquid argon charge recombination model by Cataudella et al. was adopted and a likelihood statistical analysis was performed, which gave no indications of significant dependence of the detector response to the recoil direction. The aspect ratio R of the initial ionization cloud is estimated to be 1.037 +/- 0.027 and the upper limit is R < 1.072 with 90% confidence level, Comment: 20 pages, 10 figures, submitted to Eur. Phys. J. C
Published: 2023

31. Search for dark matter annual modulation with DarkSide-50

Author: Collaboration, The DarkSide-50, Agnes, P., Albuquerque, I. F. M., Alexander, T., Alton, A. K., Ave, M., Back, H. O., Batignani, G., Biery, K., Bocci, V., Bonivento, W. M., Bottino, B., Bussino, S., Cadeddu, M., Cadoni, M., Calaprice, F., Caminata, A., Campos, M. D., Canci, N., Caravati, M., Cargioli, N., Cariello, M., Carlini, M., Cataudella, V., Cavalcante, P., Cavuoti, S., Chashin, S., Chepurnov, A., Cicalò, C., Covone, G., D'Angelo, D., Davini, S., De Candia, A., De Cecco, S., De Filippis, G., De Rosa, G., Derbin, A. V., Devoto, A., D'Incecco, M., Dionisi, C., Dordei, F., Downing, M., D'Urso, D., Fairbairn, M., Fiorillo, G., Franco, D., Gabriele, F., Galbiati, C., Ghiano, C., Giganti, C., Giovanetti, G. K., Goretti, A. M., di Cortona, G. Grilli, Grobov, A., Gromov, M., Guan, M., Gulino, M., Hackett, B. R., Herner, K., Hessel, T., Hosseini, B., Hubaut, F., Hugues, T., Hungerford, E. V., Ianni, An., Ippolito, V., Keeter, K., Kendziora, C. L., Kimura, M., Kochanek, I., Korablev, D., Korga, G., Kubankin, A., Kuss, M., Kuźniak, M., La Commara, M., Lai, M., Li, X., Lissia, M., Longo, G., Lychagina, O., Machulin, I. N., Mapelli, L. P., Mari, S. M., Maricic, J., Messina, A., Milincic, R., Monroe, J., Morrocchi, M., Mougeot, X., Muratova, V. N., Musico, P., Nozdrina, A. O., Oleinik, A., Ortica, F., Pagani, L., Pallavicini, M., Pandola, L., Pantic, E., Paoloni, E., Pelczar, K., Pelliccia, N., Piacentini, S., Pocar, A., Poehlmann, D. M., Pordes, S., Poudel, S. S., Pralavorio, P., Price, D. D., Ragusa, F., Razeti, M., Razeto, A., Renshaw, A. L., Rescigno, M., Rode, J., Romani, A., Sablone, D., Samoylov, O., Sandford, E., Sands, W., Sanfilippo, S., Savarese, C., Schlitzer, B., Semenov, D. A., Shchagin, A., Sheshukov, A., Skorokhvatov, M. D., Smirnov, O., Sotnikov, A., Stracka, S., Suvorov, Y., Tartaglia, R., Testera, G., Tonazzo, A., Unzhakov, E. V., Vishneva, A., Vogelaar, R. B., Wada, M., Wang, H., Wang, Y., Westerdale, S., Wojcik, M. M., Xiao, X., Yang, C., and Zuzel, G.
Subjects: High Energy Physics - Experiment, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: Dark matter induced event rate in an Earth-based detector is predicted to show an annual modulation as a result of the Earth's orbital motion around the Sun. We searched for this modulation signature using the ionization signal of the DarkSide-50 liquid argon time projection chamber. No significant signature compatible with dark matter is observed in the electron recoil equivalent energy range above $40~{\rm eV_{ee}}$, the lowest threshold ever achieved in such a search., Comment: 10 pages, 5 figures
Published: 2023
Full Text: View/download PDF

32. The mean longitudinal magnetic field and its uses in radial-velocity surveys

Author: F Rescigno, A Mortier, X Dumusque, B S Lakeland, R Haywood, N Piskunov, B A Nicholson, M López-Morales, S Dalal, M Cretignier, B Klein, A Collier Cameron, A Ghedina, M Gonzalez, R Cosentino, A Sozzetti, and S H Saar
Published: 2024
Full Text: View/download PDF

33. Models of accidental dark matter with a fundamental scalar

Author: Stefano Palmisano, Francesco Rescigno, and Federica Troni
Subjects: Models for Dark Matter, Particle Nature of Dark Matter, Confinement, Grand Unification, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract We consider models of accidental dark matter, namely models in which the dark matter is a composite state that is stable thanks to an accidental symmetry of the theory. The fundamental constituents are vectorlike fermions, taken to be fragments of representations of the grand unifying gauge group SU(5), as well as a scalar singlet. All the new fields are charged under a new confining gauge group, which we take to be SU(N), leading to models with complex dark matter. We analyse the models in the context of SU(5) grand unification with a non-standard approach recently proposed in the literature. The advantage of including the scalar mainly resides in the fact that it allows several undesired accidental symmetries to be broken, leading to a larger set of viable models with respect to previous literature, in which only fermions (or only scalars) were considered. Moreover these models present distinct novelties, namely dark states with non-zero baryon and lepton number and the existence of composite hybrid states of fermions and scalars. We identify phenomena that are specific to the inclusion of the scalar and discuss possibilities to test this setup.
Published: 2024
Full Text: View/download PDF

34. Radiotherapy plus pembrolizumab for advanced urothelial carcinoma: results from the ARON-2 real-world study

Author: Mimma Rizzo, Andrey Soares, Enrique Grande, Aristotelis Bamias, Ray Manneh Kopp, Edoardo Lenci, Thomas Buttner, Samer Salah, Francesco Grillone, Icaro Thiago de Carvalho, Jose Carlos Tapia, Calogero Gucciardino, Alvaro Pinto, Alessia Mennitto, Halima Abahssain, Pasquale Rescigno, Zin Myint, Hideki Takeshita, Gian Paolo Spinelli, Lazar Popovic, Maria Giuseppa Vitale, Ondrej Fiala, Patrizia Giannatempo, Roubini Zakopoulou, Francesco Carrozza, Francesco Massari, Fernando Sabino Marques Monteiro, Maria Paola Pace, Massimo Giannini, Giandomenico Roviello, Camillo Porta, Nicola Battelli, Ravindran Kanesvaran, and Matteo Santoni
Subjects: ARON-2 study, Pembrolizumab, Radiation therapy, Stereotactic radiation therapy, Urothelial carcinoma, Real-world data, Medicine, Science
Abstract: Abstract The addition of metastasis-directed radiotherapy (MDRT) to immunotherapy in patients with advanced urothelial carcinoma (aUC) has shown promising results. We report the real-world data from the ARON-2 study (NCT05290038) on the impact of conventional (CRT) or stereotactic body radiotherapy (SBRT) on the outcome of aUC patients receiving pembrolizumab after platinum-based-chemotherapy. Medical records of 837 patients were reviewed from 60 institutions in 20 countries. Two hundred and sixty-two patients (31%) received radiotherapy (cohort A), of whom 193 (23%) received CRT and 69 (8%) received SBRT. Patients were assessed for overall survival (OS), progression-free survival (PFS), and overall response rate (ORR). Univariate and multivariate analyses were used to explore the association of variables of interest with OS and PFS. With a median follow-up of 22.7 months, the median OS was 10.2 months, 6.8 months and 16.0 months in no RT, CRT and SBRT subgroups (p = 0.005), with an 1y-OS rates of 47%, 34% and 61%, respectively (p
Published: 2024
Full Text: View/download PDF

35. Long-term responders to nivolumab in previously treated advanced renal cell carcinoma: a sub-analysis of meet-URO15 study

Author: Messina, Carlo, Catalano, Martina, Roviello, Giandomenico, Gandini, Annalice, Maruzzo, Marco, De Giorgi, Ugo, Pedrazzoli, Paolo, Sbrana, Andrea, Zucal, Paolo Andrea, Masini, Cristina, Naglieri, Emanuele, Procopio, Giuseppe, Milella, Michele, Catalano, Fabio, Fratino, Lucia, Pipitone, Stefania, Ricotta, Riccardo, Panni, Stefano, Mollica, Veronica, Soraru, Mariella, Prati, Veronica, Atzori, Francesco, Di Napoli, Marilena, Messina, Marco, Morelli, Franco, Prati, Giuseppe, Nole, Franco, Malgeri, Andrea, Tudini, Marianna, Vignani, Francesca, Cavo, Alessia, Signori, Alessio, Banna, Giuseppe Luigi, Rescigno, Pasquale, Buti, Sebastiano, Rebuzzi, Sara Elena, and Fornarini, Giuseppe
Published: 2024
Full Text: View/download PDF

36. Efficiency of charge transfer in changing the dissociation dynamics of OD+ transients formed after the photo-fragmentation of D2O

Author: Iskandar, W, Rescigno, TN, Orel, AE, Severt, T, Larsen, KA, Streeter, ZL, Jochim, B, Griffin, B, Call, D, Davis, V, McCurdy, CW, Lucchese, RR, Williams, JB, Ben-Itzhak, I, Slaughter, DS, and Weber, Th
Subjects: Physical Sciences, Chemical Sciences, Atomic, Molecular and Optical Physics, Physical Chemistry, CSD-46-All CSGB, CSD-01-AMOS-A, Engineering, Chemical Physics, Chemical sciences, Physical sciences
Abstract: We present an investigation of the relaxation dynamics of deuterated water molecules after direct photo-double ionization at 61 eV. We focus on the very rare D+ + O+ + D reaction channel in which the sequential fragmentation mechanisms were found to dominate the dynamics. Aided by theory, the state-selective formation and breakup of the transient OD+(a1Δ, b1Σ+) is traced, and the most likely dissociation path-OD+: a1Δ or b1Σ+ → A 3Π → X 3Σ- → B 3Σ--involving a combination of spin-orbit and non-adiabatic charge transfer transitions is determined. The multi-step transition probability of this complex transition sequence in the intermediate fragment ion is directly evaluated as a function of the energy of the transient OD+ above its lowest dissociation limit from the measured ratio of the D+ + O+ + D and competing D+ + D+ + O sequential fragmentation channels, which are measured simultaneously. Our coupled-channel time-dependent dynamics calculations reproduce the general trends of these multi-state relative transition rates toward the three-body fragmentation channels.
Published: 2023

37. Atomic autoionization in the photo-dissociation of super-excited deuterated water molecules fragmenting into D + + O + + D

Author: Iskandar, W, Rescigno, TN, Orel, AE, Larsen, KA, Griffin, B, Call, D, Davis, V, Jochim, B, Severt, T, Williams, JB, Ben-Itzhak, I, Slaughter, DS, and Weber, Th
Subjects: Physical Sciences, Chemical Sciences, Atomic, Molecular and Optical Physics, Physical Chemistry, CSD-46-All CSGB, CSD-01-AMOS-A, Chemical Physics
Abstract: We present the relaxation dynamics of deuterated water molecules via autoionization, initiated by the absorption of a 61 eV photon, producing the very rare D+ + O+ + D breakup channel. We employ the COLd target recoil ion momentum spectroscopy method to measure the 3D momenta of the ionic fragments and emitted electrons from the dissociating molecule in coincidence. We interpret the results using the potential energy surfaces extracted from multi-reference configuration interaction calculations. The measured particle energy distributions can be related to a super-excited monocationic state located above the double ionization threshold of D2O. The autoionized electron energy shows a sharp distribution centered around 0.5 eV, which is a signature of the atomic oxygen autoionization occurring in the direct and sequential dissociation processes of D2O+* at a large internuclear distance. In this way, an O+ radical fragment and a low-energy electron are created, both of which can trigger secondary reactions in their environment.
Published: 2023

38. Bounds and Algorithms for Frameproof Codes and Related Combinatorial Structures

Author: Dalai, Marco, Della Fiore, Stefano, Rescigno, Adele A., and Vaccaro, Ugo
Subjects: Computer Science - Information Theory, Computer Science - Data Structures and Algorithms
Abstract: In this paper, we study upper bounds on the minimum length of frameproof codes introduced by Boneh and Shaw to protect copyrighted materials. A $q$-ary $(k,n)$-frameproof code of length $t$ is a $t \times n$ matrix having entries in $\{0,1,\ldots, q-1\}$ and with the property that for any column $\mathbf{c}$ and any other $k$ columns, there exists a row where the symbols of the $k$ columns are all different from the corresponding symbol (in the same row) of the column $\mathbf{c}$. In this paper, we show the existence of $q$-ary $(k,n)$-frameproof codes of length $t = O(\frac{k^2}{q} \log n)$ for $q \leq k$, using the Lov\'asz Local Lemma, and of length $t = O(\frac{k}{\log(q/k)}\log(n/k))$ for $q > k$ using the expurgation method. Remarkably, for the practical case of $q \leq k$ our findings give codes whose length almost matches the lower bound $\Omega(\frac{k^2}{q\log k} \log n)$ on the length of any $q$-ary $(k,n)$-frameproof code and, more importantly, allow us to derive an algorithm of complexity $O(t n^2)$ for the construction of such codes., Comment: 5 pages plus extra one reference page, accepted to the IEEE Information Theory Workshop (ITW 2023)
Published: 2023

39. Search for low mass dark matter in DarkSide-50: the bayesian network approach

Author: Collaboration, The DarkSide-50, Agnes, P., Albuquerque, I. F. M., Alexander, T., Alton, A. K., Ave, M., Back, H. O., Batignani, G., Biery, K., Bocci, V., Bonivento, W. M., Bottino, B., Bussino, S., Cadeddu, M., Cadoni, M., Calaprice, F., Caminata, A., Campos, M. D., Canci, N., Caravati, M., Cargioli, N., Cariello, M., Carlini, M., Cataudella, V., Cavalcante, P., Cavuoti, S., Chashin, S., Chepurnov, A., Cicalò, C., Covone, G., D'Angelo, D., Davini, S., De Candia, A., De Cecco, S., De Filippis, G., De Rosa, G., Derbin, A. V., Devoto, A., D'Incecco, M., Dionisi, C., Dordei, F., Downing, M., D'Urso, D., Fairbairn, M., Fiorillo, G., Franco, D., Gabriele, F., Galbiati, C., Ghiano, C., Giganti, C., Giovanetti, G. K., Goretti, A. M., di Cortona, G. Grilli, Grobov, A., Gromov, M., Guan, M., Gulino, M., Hackett, B. R., Herner, K., Hessel, T., Hosseini, B., Hubaut, F., Hungerford, E. V., Ianni, An., Ippolito, V., Keeter, K., Kendziora, C. L., Kimura, M., Kochanek, I., Korablev, D., Korga, G., Kubankin, A., Kuss, M., La Commara, M., Lai, M., Li, X., Lissia, M., Longo, G., Lychagina, O., Machulin, I. N., Mapelli, L. P., Mari, S. M., Maricic, J., Messina, A., Milincic, R., Monroe, J., Morrocchi, M., Mougeot, X., Muratova, V. N., Musico, P., Nozdrina, A. O., Oleinik, A., Ortica, F., Pagani, L., Pallavicini, M., Pandola, L., Pantic, E., Paoloni, E., Pelczar, K., Pelliccia, N., Piacentini, S., Pocar, A., Poehlmann, D. M., Pordes, S., Poudel, S. S., Pralavorio, P., Price, D. D., Ragusa, F., Razeti, M., Razeto, A., Renshaw, A. L., Rescigno, M., Rode, J., Romani, A., Sablone, D., Samoylov, O., Sandford, E., Sands, W., Sanfilippo, S., Savarese, C., Schlitzer, B., Semenov, D. A., Shchagin, A., Sheshukov, A., Skorokhvatov, M. D., Smirnov, O., Sotnikov, A., Stracka, S., Suvorov, Y., Tartaglia, R., Testera, G., Tonazzo, A., Unzhakov, E. V., Vishneva, A., Vogelaar, R. B., Wada, M., Wang, H., Wang, Y., Westerdale, S., Wojcik, M. M., Xiao, X., Yang, C., and Zuzel, G.
Subjects: High Energy Physics - Experiment, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: We present a novel approach for the search of dark matter in the DarkSide-50 experiment, relying on Bayesian Networks. This method incorporates the detector response model into the likelihood function, explicitly maintaining the connection with the quantity of interest. No assumptions about the linearity of the problem or the shape of the probability distribution functions are required, and there is no need to morph signal and background spectra as a function of nuisance parameters. By expressing the problem in terms of Bayesian Networks, we have developed an inference algorithm based on a Markov Chain Monte Carlo to calculate the posterior probability. A clever description of the detector response model in terms of parametric matrices allows us to study the impact of systematic variations of any parameter on the final results. Our approach not only provides the desired information on the parameter of interest, but also potential constraints on the response model. Our results are consistent with recent published analyses and further refine the parameters of the detector response model., Comment: 24 pages, 12 figures, 1 table
Published: 2023
Full Text: View/download PDF

40. Porphyromonas gingivalis fuels colorectal cancer through CHI3L1-mediated iNKT cell-driven immune evasion

Author: Angélica Díaz-Basabe, Georgia Lattanzi, Federica Perillo, Chiara Amoroso, Alberto Baeri, Andrea Farini, Yvan Torrente, Giuseppe Penna, Maria Rescigno, Michele Ghidini, Elisa Cassinotti, Ludovica Baldari, Luigi Boni, Maurizio Vecchi, Flavio Caprioli, Federica Facciotti, and Francesco Strati
Subjects: iNKT cells, CRC, Porphyromonas gingivalis, CHI3L1, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract: The interaction between the gut microbiota and invariant Natural Killer T (iNKT) cells plays a pivotal role in colorectal cancer (CRC). The pathobiont Fusobacterium nucleatum influences the anti-tumor functions of CRC-infiltrating iNKT cells. However, the impact of other bacteria associated with CRC, like Porphyromonas gingivalis, on their activation status remains unexplored. In this study, we demonstrate that mucosa-associated P. gingivalis induces a protumour phenotype in iNKT cells, subsequently influencing the composition of mononuclear-phagocyte cells within the tumor microenvironment. Mechanistically, in vivo and in vitro experiments showed that P. gingivalis reduces the cytotoxic functions of iNKT cells, hampering the iNKT cell lytic machinery through increased expression of chitinase 3-like-1 protein (CHI3L1). Neutralization of CHI3L1 effectively restores iNKT cell cytotoxic functions suggesting a therapeutic potential to reactivate iNKT cell-mediated antitumour immunity. In conclusion, our data demonstrate how P. gingivalis accelerates CRC progression by inducing the upregulation of CHI3L1 in iNKT cells, thus impairing their cytotoxic functions and promoting host tumor immune evasion.
Published: 2024
Full Text: View/download PDF

41. Banana-shaped survival curves of metastatic renal cell carcinoma treated with first-line immune-combinations, not just a matter of 'palateau'

Author: Sara Elena Rebuzzi, Giuseppe Fornarini, Alessio Signori, Pasquale Rescigno, Giuseppe Luigi Banna, and Sebastiano Buti
Subjects: Renal cell carcinoma, immune checkpoint inhibitor, immuno-combination, immunotherapy, survival outcomes, Immunologic diseases. Allergy, RC581-607, Therapeutics. Pharmacology, RM1-950
Abstract: ABSTRACTThe first-line therapy of metastatic renal cell carcinoma (mRCC) has revolutionized with the approval of immune checkpoint inhibitors (ICIs) in combination with or without tyrosine kinase inhibitors (TKIs). The choice among the many different immuno-combinations (ICI-ICI or ICI-TKI) is challenging due to the lack of predictive factors. The different shapes of the Kaplan–Meier survival curves (e.g. “banana-shaped curves”) have raised many questions on the long-term survival benefit. Here, we analyzed the factors that could have impacted the different long-term survival, including the prognostic factors distribution (IMDC score), histological factors (sarcomatoid features, PD-L1 expression), and treatment characteristics (mechanism of action, duration, discontinuation rate). This overview highlights the factors that should be considered in the first-line setting for the patients’ therapeutic choice and prognostic assessment. They are also fundamental parameters to examined for head-to-head studies and real-life, large-scale studies.
Published: 2024
Full Text: View/download PDF

42. Baryonic thermal screening mass at NLO

Author: Leonardo Giusti, M. Laine, Davide Laudicina, Michele Pepe, and Pietro Rescigno
Subjects: Finite Temperature or Finite Density, Properties of Hadrons, Resummation, Quark-Gluon Plasma, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract We determine the resummed 1-loop correction to a baryonic thermal screening mass. The calculation is carried out in the framework of a dimensionally reduced effective theory, where quarks are heavy fields due to their non-zero Matsubara frequencies. The correction due to interactions is computed at O(g 2) in the coupling constant. In order to solve a 3-body Schrödinger equation, we exploit a two-dimensional generalization of the hyperspherical harmonics method. At electroweak scale temperatures, the NLO correction represents a ∼ 4.6% increase of the free-theory value 3πT of the screening mass.
Published: 2024
Full Text: View/download PDF

43. International multicenter real-world REGistry for patients with metastatic renAL cell carcinoma – Meet-URO 33 study (REGAL study)

Author: Sara Elena Rebuzzi, Giuseppe Fornarini, Alessio Signori, Sebastiano Buti, Giuseppe Procopio, Ugo De Giorgi, Sandro Pignata, Emanuele Naglieri, Marco Maruzzo, Giuseppe Luigi Banna, Pasquale Rescigno, Carlo Messina, Alvise Mattana, Umberto Basso, and Davide Bimbatti
Subjects: Metastatic renal cell carcinoma, Immunotherapy, Immune checkpoint inhibitor, Clinical practice, Real-world, IMDC score, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Abstract Background Nowadays, different therapeutic options are available for the first-line treatment of metastatic renal cell carcinoma (mRCC). Immuno-combinations are the standard first-line therapy in all mRCC patients regardless of the International Metastatic RCC Database Consortium (IMDC) risk category, even though TKI monotherapy is still a therapeutic option in selected patients. However, comparisons between the different first-line treatment strategies are lacking and few real-world data are available in this setting. For this reason, the regimen choice represents an important issue in clinical practice and the optimal treatment sequence remains unclear. Methods The REGAL study is a multicentric prospective observational study enrolling mRCC patients treated with first-line systemic therapy according to clinical practice in a real-world setting. A retrospective cohort of mRCC patients who received first-line systemic therapy from the 1st of January 2021 will also be included. The primary objective is to identify potential prognostic and predictive factors that could help guide the treatment choice; secondary objectives included the assessment of the prognostic performance of the novel prognostic Meet-URO score (IMDC score + neutrophil-to-lymphocyte ratio + bone metastases) compared with the IMDC score and the comparison between treatment strategies according to response and survival outcomes and toxicity profile. Discussion Considering the high number of therapeutic first-line strategies available for mRCC, the identification of clinical prognostic and predictive factors to candidate patients to a preferable systemic therapy is still an unmet clinical need. The Meet-URO 33 study aims to provide a large-scale real-world database on mRCC patients, to identify the clinical predictive and prognostic factors and the different performances between the ICI-based combinations according to response, survival and toxicity. Trial Registration CESC IOV 2023-78.
Published: 2024
Full Text: View/download PDF

44. Sensitivity projections for a dual-phase argon TPC optimized for light dark matter searches through the ionization channel

Author: Agnes, P., Ahmad, I., Albergo, S., Albuquerque, I. F. M., Alexander, T., Alton, A. K., Amaudruz, P., Corona, M. Atzori, Auty, D. J., Ave, M., Avetisov, I. Ch., Avetisov, R. I., Azzolini, O., Back, H. O., Balmforth, Z., Barbarian, V., Olmedo, A. Barrado, Barrillon, P., Basco, A., Batignani, G., Berzin, E., Bondar, A., Bonivento, W. M., Borisova, E., Bottino, B., Boulay, M. G., Buccino, G., Bussino, S., Busto, J., Buzulutskov, A., Cadeddu, M., Cadoni, M., Caminata, A., Canci, N., Capra, A., Caprioli, S., Caravati, M., Cárdenas-Montes, M., Cargioli, N., Carlini, M., Castello, P., Cataudella, V., Cavalcante, P., Cavuoti, S., Cebrian, S., Ruiz, J. M. Cela, Chashin, S., Chepurnov, A., Chyhyrynets, E, Cicalò, C., Cifarelli, L., Cintas, D., Cocco, V., Vilda, E. Conde, Consiglio, L., Copello, S., Covone, G., Cross, S., Czudak, P., D'Aniello, M., D'Auria, S., Rolo, M. D. Da Rocha, Dadoun, O., Daniel, M., Davini, S., De Candia, A., De Cecco, S., De Falco, A., De Filippis, G., De Gruttola, D., De Pasquale, S., De Rosa, G., Dellacasa, G., Derbin, A. V., Devoto, A., Di Capua, F., Di Noto, L., Di Stefano, P., Dionisi, C., Dolganov, G., Dordei, F., Doria, L., Erjavec, T., Diaz, M. Fernandez, Fiorillo, G., Franceschi, A., Franchini, P., Franco, D., Frolov, E., Funicello, N., Gabriele, F., Gahan, D., Galbiati, C., Gallina, G., Gallus, G., Garbini, M., Abia, P. Garcia, Gendotti, A., Ghiano, C., Giampaolo, R. A., Giganti, C., Giorgi, M. A., Giovanetti, G. K., Casanueva, V. Goicoechea, Gola, A., Gorman, D., Diaz, R. Graciani, Grauso, G., di Cortona, G. Grilli, Grobov, A., Gromov, M., Guan, M., Guerzoni, M., Gulino, M., Guo, C., Hackett, B. R., Hall, J. B., Hallin, A. L., Hamer, A., Helton, H., Haranczyk, M., Hessel, T., Hill, S., Horikawa, S., Hubaut, F., Hugues, T., Hungerford, E. V., Ianni, An., Ippolito, V., Jillings, C., Kachru, P., Kemp, A. A., Kendziora, C. L., Keppel, G., Khomyakov, A. V., Kimura, M., Kochanek, I., Kondo, K., Korga, G., Koulosousas, S., Kubankin, A., Kuss, M., Kuźniak, M., La Commara, M., Lai, M., Guirriec, E. Le, Leason, E., Li, X., Lidey, L., Lipp, J., Lissia, M., Longo, G., Luzzi, L., Macfadyen, O., Machulin, I. N., Manthos, I., Mapelli, L., Margotti, A., Mari, S. M., Mariani, C., Maricic, J., Marini, A., Martínez, M., Martoff, C. J., Masoni, A., Mavrokoridis, K., Mazzi, A., McDonald, A. B., Messina, A., Milincic, R., Moggi, A., Moharana, A., Monroe, J., Morrocchi, M., Mozhevitina, E. N., Mróz, T., Muratova, V. N., Muscas, C., Musico, P., Nania, R., Napolitano, T., Nessi, M., Nieradka, G., Nikolopoulos, K., Nikulin, I., Nowak, J., Olchansky, K., Oleinik, A., Oleynikov, V., Organtini, P., de Solórzano, A. Ortiz, Pagani, L., Pallavicini, M., Pandola, L., Pantic, E., Paoloni, E., Paternoster, G., Pegoraro, P. A., Pelczar, K., Pellegrino, C., Perotti, F., Pesudo, V., Piacentini, S., Pietropaolo, F., Pino, N., Pira, C., Pocar, A., Poehlmann, D. M., Pordes, S., Pralavorio, P., Price, D., Raffaelli, F., Ragusa, F., Ramachers, Y., Ramirez, A., Razeti, M., Razeto, A., Renshaw, A. L., Rescigno, M., Resnati, F., Retiere, F., Rignanese, L. P., Ripoli, C., Rivetti, A., Roberts, A., Roberts, C., Rode, J., Rogers, G., Romero, L., Rossi, M., Rubbia, A., Sadashivajois, S., Saffold, T. R., Samoylov, O., Sandford, E., Sanfilippo, S., Santone, D., Santorelli, R., Savarese, C., Scapparone, E., Scioli, G., Semenov, D. A., Shchagin, A., Sheshukov, A., Simeone, M., Skensved, P., Skorokhvatov, M. D., Smirnov, O., Smirnova, T., Smith, B., Sokolov, A., Spangenberg, M., Stefanizzi, R., Steri, A., Stracka, S., Strickland, V., Stringer, M., Sulis, S., Sung, A., Suvorov, Y., Szelc, A. M., Türkoğ, C., Tartaglia, R., Taylor, A., Taylor, J., Tedesco, S., Testera, G., Thieme, K., Thorpe, T. N., Tonazzo, A., Torres-Lara, S., Tricomi, A., Unzhakov, E. V., John, T. Vallivilayil, Van Uffelen, M., Viant, T., Viel, S., Vishneva, A., Vogelaar, R. B., Vossebeld, J., Wada, M., Walczak, M. B., Wang, Y., Westerdale, S., Wheadon, R. J., Williams, L., Wingerter-Seez, I., Wojaczyński, R., Wojcik, Ma. M., Wojcik, Ma., Wright, T., Xie, Y., Yang, C., Zabihi, A., Zakhary, P., Zani, A., Zichichi, A., Zuzel, G., and Zykova, M. P.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: Dark matter lighter than 10 GeV/c$^2$ encompasses a promising range of candidates. A conceptual design for a new detector, DarkSide-LowMass, is presented, based on the DarkSide-50 detector and progress toward DarkSide-20k, optimized for a low-threshold electron-counting measurement. Sensitivity to light dark matter is explored for various potential energy thresholds and background rates. These studies show that DarkSide-LowMass can achieve sensitivity to light dark matter down to the solar neutrino floor for GeV-scale masses and significant sensitivity down to 10 MeV/c$^2$ considering the Migdal effect or interactions with electrons. Requirements for optimizing the detector's sensitivity are explored, as are potential sensitivity gains from modeling and mitigating spurious electron backgrounds that may dominate the signal at the lowest energies.
Published: 2022
Full Text: View/download PDF

45. Search for dark matter-nucleon interactions via Migdal effect with DarkSide-50

Author: Collaboration, The DarkSide-50, Agnes, P., Albuquerque, I. F. M., Alexander, T., Alton, A. K., Ave, M., Back, H. O., Batignani, G., Biery, K., Bocci, V., Bonivento, W. M., Bottino, B., Bussino, S., Cadeddu, M., Cadoni, M., Calaprice, F., Caminata, A., Campos, M. D., Canci, N., Caravati, M., Cariello, M., Carlini, M., Carpinelli, M., Cataudella, V., Cavalcante, P., Cavuoti, S., Chashin, S., Chepurnov, A., Cicalò, C., Covone, G., D'Angelo, D., Davini, S., De Candia, A., De Cecco, S., De Filippis, G., De Rosa, G., Derbin, A. V., Devoto, A., D'Incecco, M., Dionisi, C., Dordei, F., Downing, M., D'Urso, D., Fairbairn, M., Fiorillo, G., Franco, D., Gabriele, F., Galbiati, C., Ghiano, C., Giganti, C., Giovanetti, G. K., Goretti, A. M., di Cortona, G. Grilli, Grobov, A., Gromov, M., Guan, M., Gulino, M., Hackett, B. R., Herner, K., Hessel, T., Hosseini, B., Hubaut, F., Hungerford, E. V., Ianni, An., Ippolito, V., Keeter, K., Kendziora, C. L., Kimura, M., Kochanek, I., Korablev, D., Korga, G., Kubankin, A., Kuss, M., La Commara, M., Lai, M., Li, X., Lissia, M., Longo, G., Lychagina, O., Machulin, I. N., Mapelli, L. P., Mari, S. M., Maricic, J., Messina, A., Milincic, R., Monroe, J., Morrocchi, M., Mougeot, X., Muratova, V. N., Musico, P., Nozdrina, A. O., Oleinik, A., Ortica, F., Pagani, L., Pallavicini, M., Pandola, L., Pantic, E., Paoloni, E., Pelczar, K., Pelliccia, N., Piacentini, S., Picciau, E., Pocar, A., Poehlmann, D. M., Pordes, S., Poudel, S. S., Pralavorio, P., Price, D. D., Ragusa, F., Razeti, M., Razeto, A., Renshaw, A. L., Rescigno, M., Rode, J., Romani, A., Sablone, D., Samoylov, O., Sands, W., Sanfilippo, S., Sanford, E., Savarese, C., Schlitzer, B., Semenov, D. A., Shchagin, A., Sheshukov, A., Skorokhvatov, M. D., Smirnov, O., Sotnikov, A., Stracka, S., Suvorov, Y., Tartaglia, R., Testera, G., Tonazzo, A., Unzhakov, E. V., Vishneva, A., Vogelaar, R. B., Wada, M., Wang, H., Wang, Y., Westerdale, S., Wojcik, M. M., Xiao, X., Yang, C., and Zuzel, G.
Subjects: High Energy Physics - Experiment, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: Dark matter elastic scattering off nuclei can result in the excitation and ionization of the recoiling atom through the so-called Migdal effect. The energy deposition from the ionization electron adds to the energy deposited by the recoiling nuclear system and allows for the detection of interactions of sub-GeV/c$^2$ mass dark matter. We present new constraints for sub-GeV/c$^2$ dark matter using the dual-phase liquid argon time projection chamber of the DarkSide-50 experiment with an exposure of (12306 $\pm$ 184) kg d. The analysis is based on the ionization signal alone and significantly enhances the sensitivity of DarkSide-50, enabling sensitivity to dark matter with masses down to 40 MeV/c$^2$. Furthermore, it sets the most stringent upper limit on the spin independent dark matter nucleon cross section for masses below $3.6$ GeV/c$^2$., Comment: 7 pages, 3 figures
Published: 2022
Full Text: View/download PDF

46. Search for dark matter particle interactions with electron final states with DarkSide-50

Author: Collaboration, The DarkSide-50, Agnes, P., Albuquerque, I. F. M., Alexander, T., Alton, A. K., Ave, M., Back, H. O., Batignani, G., Biery, K., Bocci, V., Bonivento, W. M., Bottino, B., Bussino, S., Cadeddu, M., Cadoni, M., Calaprice, F., Caminata, A., Campos, M. D., Canci, N., Caravati, M., Cariello, M., Carlini, M., Carpinelli, M., Cataudella, V., Cavalcante, P., Cavuoti, S., Chashin, S., Chepurnov, A., Cicalò, C., Covone, G., D'Angelo, D., Davini, S., De Candia, A., De Cecco, S., De Filippis, G., De Rosa, G., Derbin, A. V., Devoto, A., D'Incecco, M., Dionisi, C., Dordei, F., Downing, M., D'Urso, D., Fiorillo, G., Franco, D., Gabriele, F., Galbiati, C., Ghiano, C., Giganti, C., Giovanetti, G. K., Goretti, A. M., di Cortona, G. Grilli, Grobov, A., Gromov, M., Guan, M., Gulino, M., Hackett, B. R., Herner, K., Hessel, T., Hosseini, B., Hubaut, F., Hungerford, E. V., Ianni, An., Ippolito, V., Keeter, K., Kendziora, C. L., Kimura, M., Kochanek, I., Korablev, D., Korga, G., Kubankin, A., Kuss, M., La Commara, M., Lai, M., Li, X., Lissia, M., Longo, G., Lychagina, O., Machulin, I. N., Mapelli, L. P., Mari, S. M., Maricic, J., Messina, A., Milincic, R., Monroe, J., Morrocchi, M., Mougeot, X., Muratova, V. N., Musico, P., Nozdrina, A. O., Oleinik, A., Ortica, F., Pagani, L., Pallavicini, M., Pandola, L., Pantic, E., Paoloni, E., Pelczar, K., Pelliccia, N., Piacentini, S., Picciau, E., Pocar, A., Poehlmann, D. M., Pordes, S., Poudel, S. S., Pralavorio, P., Price, D. D., Ragusa, F., Razeti, M., Razeto, A., Renshaw, A. L., Rescigno, M., Rode, J., Romani, A., Sablone, D., Samoylov, O., Sands, W., Sanfilippo, S., Sanford, E., Savarese, C., Schlitzer, B., Semenov, D. A., Shchagin, A., Sheshukov, A., Skorokhvatov, M. D., Smirnov, O., Sotnikov, A., Stracka, S., Suvorov, Y., Tartaglia, R., Testera, G., Tonazzo, A., Unzhakov, E. V., Vishneva, A., Vogelaar, R. B., Wada, M., Wang, H., Wang, Y., Westerdale, S., Wojcik, M. M., Xiao, X., Yang, C., and Zuzel, G.
Subjects: High Energy Physics - Experiment, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: We present a search for dark matter particles with sub-GeV/$c^2$ masses whose interactions have final state electrons using the DarkSide-50 experiment's (12306 $\pm$ 184) kg d low-radioactivity liquid argon exposure. By analyzing the ionization signals, we exclude new parameter space for the dark matter-electron cross section $\bar{\sigma}_e$, the axioelectric coupling constant $g_{Ae}$, and the dark photon kinetic mixing parameter $\kappa$. We also set the first dark matter direct-detection constraints on the mixing angle $\left|U_{e4}\right|^2$ for keV sterile neutrinos., Comment: 6 pages, 2 figures
Published: 2022
Full Text: View/download PDF

47. Search for low-mass dark matter WIMPs with 12 ton-day exposure of DarkSide-50

Author: Collaboration, The DarkSide-50, Agnes, P., Albuquerque, I. F. M., Alexander, T., Alton, A. K., Ave, M., Back, H. O., Batignani, G., Biery, K., Bocci, V., Bonivento, W. M., Bottino, B., Bussino, S., Cadeddu, M., Cadoni, M., Calaprice, F., Caminata, A., Canci, N., Caravati, M., Cariello, M., Carlini, M., Carpinelli, M., Cataudella, V., Cavalcante, P., Cavuoti, S., Chashin, S., Chepurnov, A., Cicalò, C., Covone, G., D'Angelo, D., Davini, S., De Candia, A., De Cecco, S., De Filippis, G., De Rosa, G., Derbin, A. V., Devoto, A., D'Incecco, M., Dionisi, C., Dordei, F., Downing, M., D'Urso, D., Fiorillo, G., Franco, D., Gabriele, F., Galbiati, C., Ghiano, C., Giganti, C., Giovanetti, G. K., Goretti, A. M., di Cortona, G. Grilli, Grobov, A., Gromov, M., Guan, M., Gulino, M., Hackett, B. R., Herner, K., Hessel, T., Hosseini, B., Hubaut, F., Hungerford, E. V., Ianni, An., Ippolito, V., Keeter, K., Kendziora, C. L., Kimura, M., Kochanek, I., Korablev, D., Korga, G., Kubankin, A., Kuss, M., La Commara, M., Lai, M., Li, X., Lissia, M., Longo, G., Lychagina, O., Machulin, I. N., Mapelli, L. P., Mari, S. M., Maricic, J., Messina, A., Milincic, R., Monroe, J., Morrocchi, M., Mougeot, X., Muratova, V. N., Musico, P., Nozdrina, A. O., Oleinik, A., Ortica, F., Pagani, L., Pallavicini, M., Pandola, L., Pantic, E., Paoloni, E., Pelczar, K., Pelliccia, N., Piacentini, S., Picciau, E., Pocar, A., Poehlmann, D. M., Pordes, S., Poudel, S. S., Pralavorio, P., Price, D. D., Ragusa, F., Razeti, M., Razeto, A., Renshaw, A. L., Rescigno, M., Rode, J., Romani, A., Sablone, D., Samoylov, O., Sands, W., Sanfilippo, S., Sanford, E., Savarese, C., Schlitzer, B., Semenov, D. A., Shchagin, A., Sheshukov, A., Skorokhvatov, M. D., Smirnov, O., Sotnikov, A., Stracka, S., Suvorov, Y., Tartaglia, R., Testera, G., Tonazzo, A., Unzhakov, E. V., Vishneva, A., Vogelaar, R. B., Wada, M., Wang, H., Wang, Y., Westerdale, S., Wojcik, M. M., Xiao, X., Yang, C., and Zuzel, G.
Subjects: High Energy Physics - Experiment, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: We report on the search for dark matter WIMPs in the mass range below 10 GeV/c$^2$, from the analysis of the entire dataset acquired with a low-radioactivity argon target by the DarkSide-50 experiment at LNGS. The new analysis benefits from more accurate calibration of the detector response, improved background model, and better determination of systematic uncertainties, allowing us to accurately model the background rate and spectra down to 0.06 keV$_{er}$. A 90% C.L. exclusion limit for the spin-independent cross section of 3 GeV/c$^2$ mass WIMP on nucleons is set at 6$\times$10$^{-43}$ cm$^2$, about a factor 10 better than the previous DarkSide-50 limit. This analysis extends the exclusion region for spin-independent dark matter interactions below the current experimental constraints in the $[1.2, 3.6]$ GeV/c$^2$ WIMP mass range., Comment: 11 pages, 12 figures
Published: 2022
Full Text: View/download PDF

48. Baryonic screening masses in QCD at high temperature

Author: Leonardo Giusti, Tim Harris, Davide Laudicina, Michele Pepe, and Pietro Rescigno
Subjects: Physics, QC1-999
Abstract: We compute the baryonic screening masses of the nucleon and of its negative parity partner in thermal QCD with Nf=3 massless quarks for a wide range of temperatures, from T∼1 GeV up to ∼160 GeV. The computation is performed by Monte Carlo simulations of lattice QCD with O(a)-improved Wilson fermions by exploiting a recently proposed strategy to study non-perturbatively QCD at very high temperature. Very large spatial extensions are considered in order to have negligible finite volume effects. For each temperature we have simulated 3 or 4 values of the lattice spacing, so as to perform the continuum limit extrapolation with confidence at a few permille accuracy. The degeneracy of the positive and negative parity-state screening masses, expected from Ward identities associated to non-singlet axial transformations, provides further evidence for the restoration of chiral symmetry in the high temperature regime of QCD. In the entire range of temperatures explored, the baryonic masses deviate from the free theory result, 3πT, by 4–8%. The contribution due to the interactions is clearly visible up to the highest temperature considered, and cannot be explained by the expected leading behavior in the QCD coupling constant g over the entire range of temperatures explored.
Published: 2024
Full Text: View/download PDF

49. Targeting a STING agonist to perivascular macrophages in prostate tumors delays resistance to androgen deprivation therapy

Author: Christopher Bailey, Johann De Bono, Munitta Muthana, Mateus Crespo, Bora Gurel, Pasquale Rescigno, Matthew Fisher, Wayne A Phillips, Richard Allen, Harry Nunns, Janet E Brown, Haider Al-janabi, Katy Moyes, Anna Junker-Jensen, Helen B Pearson, Mary-Ellen Taplin, and Claire E Lewis
Subjects: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Background Androgen deprivation therapy (ADT) is a front-line treatment for prostate cancer. In some men, their tumors can become refractory leading to the development of castration-resistant prostate cancer (CRPC). This causes tumors to regrow and metastasize, despite ongoing treatment, and impacts negatively on patient survival. ADT is known to stimulate the accumulation of immunosuppressive cells like protumoral tumor-associated macrophages (TAMs), myeloid-derived suppressor cells and regulatory T cells in prostate tumors, as well as hypofunctional T cells. Protumoral TAMs have been shown to accumulate around tumor blood vessels during chemotherapy and radiotherapy in other forms of cancer, where they drive tumor relapse. Our aim was to see whether such perivascular (PV) TAMs also accumulate in ADT-treated prostate tumors prior to CRPC, and, if so, whether selectively inducing them to express a potent immunostimulant, interferon beta (IFNβ), would stimulate antitumor immunity and delay CRPC.Methods We used multiplex immunofluorescence to assess the effects of ADT on the distribution and activation status of TAMs, CD8+T cells, CD4+T cells and NK cells in mouse and/or human prostate tumors. We then used antibody-coated, lipid nanoparticles (LNPs) to selectively target a STING agonist, 2′3′-cGAMP (cGAMP), to PV TAMs in mouse prostate tumors during ADT.Results TAMs accumulated at high density around blood vessels in response to ADT and expressed markers of a protumoral phenotype including folate receptor-beta (FR-β), MRC1 (CD206), CD169 and VISTA. Additionally, higher numbers of inactive (PD-1-) CD8+T cells and reduced numbers of active (CD69+) NK cells were present in these PV tumor areas. LNPs coated with an antibody to FR-β selectively delivered cGAMP to PV TAMs in ADT-treated tumors, where they activated STING and upregulated the expression of IFNβ. This resulted in a marked increase in the density of active CD8+T cells (along with CD4+T cells and NK cells) in PV tumor areas, and significantly delayed the onset of CRPC. Antibody depletion of CD8+T cells during LNP administration demonstrated the essential role of these cells in delay in CRPC induced by LNPs.Conclusion Together, our data indicate that targeting a STING agonist to PV TAMs could be used to extend the treatment window for ADT in prostate cancer.
Published: 2024
Full Text: View/download PDF

50. Sodium levels and immunotherapy efficacy in mRCC patients with bone metastases: sub analysis of Meet-Uro 15 study

Author: Martina Catalano, Sara Elena Rebuzzi, Marco Maruzzo, Ugo De Giorgi, Sebastiano Buti, Luca Galli, Giuseppe Fornarini, Paolo Andrea Zucali, Melanie Claps, Silvia Chiellino, Ilaria Zampiva, Stefania Pipitone, Riccardo Ricotta, Mariella Sorarù, Veronica Mollica, Marianna Tudini, Lucia Fratino, Veronica Prati, Orazio Caffo, Francesco Atzori, Franco Morelli, Giuseppe Prati, Franco Nolè, Francesca Vignani, Alessia Cavo, Marilena Di Napoli, Andrea Malgeri, Emanuele Naglieri, Alessio Signori, Giuseppe Luigi Banna, Pasquale Rescigno, Linda Cerbone, Lorenzo Antonuzzo, and Giandomenico Roviello
Subjects: renal cell carcinoma, bone metastases, immunotherapy, sodium levels, efficacy outcomes, Immunologic diseases. Allergy, RC581-607
Abstract: BackgroundImmune-checkpoint inhibitors (ICIs) have significantly improved metastatic renal cell carcinoma (mRCC) prognosis, although their efficacy in patients with bone metastases (BMs) remains poorly understood. We investigated the prognostic role of natremia in pretreated RCC patients with BMs receiving immunotherapy.Materials and methodsThis retrospective multicenter study included RCC patients with BMs receiving nivolumab as second-line therapy or beyond. Inclusion criteria involved baseline sodium levels (pre-ICI) and sodium levels after 4 weeks of nivolumab initiation (post-ICI). The population was divided into two groups based on the median value, and response rates, progression-free survival (PFS), and overall survival (OS) were assessed.ResultsAmong 120 eligible patients, those with pre-treatment sodium levels ≥140 mEq/L showed longer OS (18.7 vs. 12.0 months, p=0.04). Pre-treatment sodium levels ≥140 mEq/L were associated with better OS compared to levels
Published: 2024
Full Text: View/download PDF

Catalog

Books, media, physical & digital resources

See catalog results

Searchworks

Select search scope, currently: Articles Catalog books, media & more in Jio Institute collections Articles journal articles & other e-resources

Search

Search Constraints

Refine your results

Search Limiters

Topic

Publication Year Range

Language

Publication Type

Journal

Region

Database

Publisher

11,869 results on '"Rescigno A"'

Search Results

Catalog

Select search scope, currently: Articles

Catalog

books, media & more in Jio Institute collections

Articles

journal articles & other e-resources