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1. Serum dihydrotestosterone is associated with adverse myocardial remodeling in patients with aortic valve stenosis before and after aortic valve replacement

Author

Schafstedde, M., Nordmeyer, J., Berger, F., Knosalla, C., Mertins, P., Regitz-Zagrosek, V., Kuehne, T., Kraus, M., and Nordmeyer, S.

Subjects
Technology Platforms
Abstract

AIMS: Animal studies show a pivotal role of dihydrotestosterone (DHT) in pressure overload induced myocardial hypertrophy and dysfunction. The aim of our study was to evaluate the role of DHT levels and myocardial hypertrophy and myocardial protein expression in patients with severe aortic valve stenosis (AS). METHODS AND RESULTS: 43 patients (median age 68 (41-80) years) with severe AS and indication for surgical aortic valve replacement (SAVR) were prospectively enrolled. Cardiac magnetic resonance imaging including analysis of left ventricular muscle mass (LVM), fibrosis and function and laboratory tests including serum DHT levels were performed before and after SAVR. During SAVR left ventricular (LV) biopsies were performed for proteomic profiling. Serum DHT levels correlated positively with indexed LVM (LVMi, R=0.64, p

Published
2022

2. Socio-economic factors determine maternal and noenatal outcomes in women with peripartum cardiomyopathy: a study of the ESC EORP PPCM registry

Author

Sliwa-Hahnle, K, primary, Van Der Meer, P, additional, Viljoen, C, additional, Jackson, A M, additional, Petrie, M C, additional, Maggioni, A P, additional, Laroche, C, additional, Regitz-Zagrosek, V, additional, Tavazzi, L, additional, Roos-Hesselink, J W, additional, Seferovic, P, additional, Frogoudaki, A, additional, Ibrahim, B, additional, Al-Farham, H, additional, and Bauersachs, J, additional

Published
2022
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3. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice

Author

Visseren, F, Mach, F, Smulders, Y, Carballo, D, Koskinas, K, Back, M, Benetos, A, Biffi, A, Boavida, J, Capodanno, D, Cosyns, B, Crawford, C, Davos, C, Desormais, I, Di Angelantonio, E, Duran, O, Halvorsen, S, Richard Hobbs, F, Hollander, M, Jankowska, E, Michal, M, Sacco, S, Sattar, N, Tokgozoglu, L, Tonstad, S, Tsioufis, K, van Dis, I, van Gelder, I, Wanner, C, Williams, B, De Backer, G, Regitz-Zagrosek, V, Aamodt, A, Abdelhamid, M, Aboyans, V, Albus, C, Asteggiano, R, Borger, M, Brotons, C, Celutkiene, J, Cifkova, R, Cikes, M, Cosentino, F, Dagres, N, De Backer, T, De Bacquer, D, Delgado, V, Ruijter, H, Dendale, P, Drexel, H, Falk, V, Fauchier, L, Ference, B, Ferrieres, J, Ferrini, M, Fisher, M, Fliser, D, Fras, Z, Gaita, D, Giampaoli, S, Gielen, S, Graham, I, Jennings, C, Jorgensen, T, Kautzky-Willer, A, Kavousi, M, Koenig, W, Konradi, A, Kotecha, D, Landmesser, U, Lettino, M, Lewis, B, Linhart, A, Lochen, M, Makrilakis, K, Mancia, G, Marques-Vidal, P, Mcevoy, J, Mcgreavy, P, Merkely, B, Neubeck, L, Nielsen, J, Perk, J, Petersen, S, Petronio, A, Piepoli, M, Pogosova, N, Prescott, E, Ray, K, Reiner, Z, Richter, D, Ryden, L, Shlyakhto, E, Sitges, M, Sousa-Uva, M, Sudano, I, Tiberi, M, Touyz, R, Ungar, A, Monique Verschuren, W, Wiklund, O, Wood, D, Zamorano, J, Visseren F., Mach F., Smulders Y. M., Carballo D., Koskinas K. C., Back M., Benetos A., Biffi A., Boavida J. -M., Capodanno D., Cosyns B., Crawford C. A., Davos C. H., Desormais I., Di Angelantonio E., Duran O. H. F., Halvorsen S., Richard Hobbs F. D., Hollander M., Jankowska E. A., Michal M., Sacco S., Sattar N., Tokgozoglu L., Tonstad S., Tsioufis K. P., van Dis I., van Gelder I. C., Wanner C., Williams B., De Backer G., Regitz-Zagrosek V., Aamodt A. H., Abdelhamid M., Aboyans V., Albus C., Asteggiano R., Borger M. A., Brotons C., Celutkiene J., Cifkova R., Cikes M., Cosentino F., Dagres N., De Backer T., De Bacquer D., Delgado V., Ruijter H. D., Dendale P., Drexel H., Falk V., Fauchier L., Ference B. A., Ferrieres J., Ferrini M., Fisher M., Fliser D., Fras Z., Gaita D., Giampaoli S., Gielen S., Graham I., Jennings C., Jorgensen T., Kautzky-Willer A., Kavousi M., Koenig W., Konradi A., Kotecha D., Landmesser U., Lettino M., Lewis B. S., Linhart A., Lochen M. -L., Makrilakis K., Mancia G., Marques-Vidal P., McEvoy J. W., McGreavy P., Merkely B., Neubeck L., Nielsen J. C., Perk J., Petersen S. E., Petronio A. S., Piepoli M., Pogosova N. G., Prescott E. I. B., Ray K. K., Reiner Z., Richter D. J., Ryden L., Shlyakhto E., Sitges M., Sousa-Uva M., Sudano I., Tiberi M., Touyz R. M., Ungar A., Monique Verschuren W. M., Wiklund O., Wood D., Zamorano J. L., Visseren, F, Mach, F, Smulders, Y, Carballo, D, Koskinas, K, Back, M, Benetos, A, Biffi, A, Boavida, J, Capodanno, D, Cosyns, B, Crawford, C, Davos, C, Desormais, I, Di Angelantonio, E, Duran, O, Halvorsen, S, Richard Hobbs, F, Hollander, M, Jankowska, E, Michal, M, Sacco, S, Sattar, N, Tokgozoglu, L, Tonstad, S, Tsioufis, K, van Dis, I, van Gelder, I, Wanner, C, Williams, B, De Backer, G, Regitz-Zagrosek, V, Aamodt, A, Abdelhamid, M, Aboyans, V, Albus, C, Asteggiano, R, Borger, M, Brotons, C, Celutkiene, J, Cifkova, R, Cikes, M, Cosentino, F, Dagres, N, De Backer, T, De Bacquer, D, Delgado, V, Ruijter, H, Dendale, P, Drexel, H, Falk, V, Fauchier, L, Ference, B, Ferrieres, J, Ferrini, M, Fisher, M, Fliser, D, Fras, Z, Gaita, D, Giampaoli, S, Gielen, S, Graham, I, Jennings, C, Jorgensen, T, Kautzky-Willer, A, Kavousi, M, Koenig, W, Konradi, A, Kotecha, D, Landmesser, U, Lettino, M, Lewis, B, Linhart, A, Lochen, M, Makrilakis, K, Mancia, G, Marques-Vidal, P, Mcevoy, J, Mcgreavy, P, Merkely, B, Neubeck, L, Nielsen, J, Perk, J, Petersen, S, Petronio, A, Piepoli, M, Pogosova, N, Prescott, E, Ray, K, Reiner, Z, Richter, D, Ryden, L, Shlyakhto, E, Sitges, M, Sousa-Uva, M, Sudano, I, Tiberi, M, Touyz, R, Ungar, A, Monique Verschuren, W, Wiklund, O, Wood, D, Zamorano, J, Visseren F., Mach F., Smulders Y. M., Carballo D., Koskinas K. C., Back M., Benetos A., Biffi A., Boavida J. -M., Capodanno D., Cosyns B., Crawford C. A., Davos C. H., Desormais I., Di Angelantonio E., Duran O. H. F., Halvorsen S., Richard Hobbs F. D., Hollander M., Jankowska E. A., Michal M., Sacco S., Sattar N., Tokgozoglu L., Tonstad S., Tsioufis K. P., van Dis I., van Gelder I. C., Wanner C., Williams B., De Backer G., Regitz-Zagrosek V., Aamodt A. H., Abdelhamid M., Aboyans V., Albus C., Asteggiano R., Borger M. A., Brotons C., Celutkiene J., Cifkova R., Cikes M., Cosentino F., Dagres N., De Backer T., De Bacquer D., Delgado V., Ruijter H. D., Dendale P., Drexel H., Falk V., Fauchier L., Ference B. A., Ferrieres J., Ferrini M., Fisher M., Fliser D., Fras Z., Gaita D., Giampaoli S., Gielen S., Graham I., Jennings C., Jorgensen T., Kautzky-Willer A., Kavousi M., Koenig W., Konradi A., Kotecha D., Landmesser U., Lettino M., Lewis B. S., Linhart A., Lochen M. -L., Makrilakis K., Mancia G., Marques-Vidal P., McEvoy J. W., McGreavy P., Merkely B., Neubeck L., Nielsen J. C., Perk J., Petersen S. E., Petronio A. S., Piepoli M., Pogosova N. G., Prescott E. I. B., Ray K. K., Reiner Z., Richter D. J., Ryden L., Shlyakhto E., Sitges M., Sousa-Uva M., Sudano I., Tiberi M., Touyz R. M., Ungar A., Monique Verschuren W. M., Wiklund O., Wood D., and Zamorano J. L.

Published
2021

4. Gender and Social Inequalities in Awareness of Coronary Artery Disease in European Countries

Author

Daponte-Codina, Antonio, Knox, Emily C., Mateo-Rodriguez, Inmaculada, Seims, Amanda, Regitz-Zagrosek, V., Maas, A.H.E.M., Barnhoorn, Floris, Rosell-Ortiz, Fernando, Daponte-Codina, Antonio, Knox, Emily C., Mateo-Rodriguez, Inmaculada, Seims, Amanda, Regitz-Zagrosek, V., Maas, A.H.E.M., Barnhoorn, Floris, and Rosell-Ortiz, Fernando

Abstract

Contains fulltext : 247673.pdf (Publisher’s version ) (Open Access)

Published
2022

5. Gender and Social Inequalities in Awareness of Coronary Artery Disease in European Countries

Author

Daponte-Codina, A, Knox, EC, Mateo-Rodriguez, I, Seims, A, Regitz-Zagrosek, V, Maas, AHEM, White, A, Barnhoorn, F, Rosell-Ortiz, F, Daponte-Codina, A, Knox, EC, Mateo-Rodriguez, I, Seims, A, Regitz-Zagrosek, V, Maas, AHEM, White, A, Barnhoorn, F, and Rosell-Ortiz, F

Abstract

Coronary artery disease (CAD) is the single leading cause of death in Europe and the most common form of cardiovascular disease. Little is known about awareness in the European population. A cross-sectional telephone survey of 2609 individuals from six European countries was conducted to gather information on perceptions of CAD, risk factors, preventive measures, knowledge of heart attack symptoms and ability to seek emergency medical care. Level of awareness was compared according to gender, age, socioeconomic status (SES) and educational level. Women were approximately five times less likely than men to consider heart disease as a main health issue or leading cause of death (OR = 0.224, 95% CI: 0.178-0.280, OR = 0.196, 95% CI: 0.171-0.226). Additionally, women were significantly less likely to have ever had a cardiovascular screening test (OR = 0.515, 95% CI: 0.459-0.578). Only 16.3% of men and 15.3% of women were able to spontaneously identify the main symptoms of a heart attack. Almost half of the sample failed to state that they would call emergency services in case of a cardiac event. Significant differences according to age, SES and education were found for many indicators amongst both men and women. Development of a European strategy targeting improved awareness of CAD and reduced gender and social inequalities within the European population is warranted.

Published
2022

6. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice

Author

Visseren, F, Mach, F, Smulders, Y, Carballo, D, Koskinas, K, Bäck, M, Benetos, A, Biffi, A, Boavida, J, Capodanno, D, Cosyns, B, Crawford, C, Davos, C, Desormais, I, Di Angelantonio, E, Franco, O, Halvorsen, S, Hobbs, F, Hollander, M, Jankowska, E, Michal, M, Sacco, S, Sattar, N, Tokgozoglu, L, Tonstad, S, Tsioufis, K, van Dis, I, van Gelder, I, Wanner, C, Williams, B, De Backer, G, Regitz-Zagrosek, V, Aamodt, A, Abdelhamid, M, Aboyans, V, Albus, C, Asteggiano, R, Borger, M, Brotons, C, Celutkiene, J, Cifkova, R, Cikes, M, Cosentino, F, Dagres, N, De Backer, T, De Bacquer, D, Delgado, V, Den Ruijter, H, Dendale, P, Drexel, H, Falk, V, Fauchier, L, Ference, B, Ferrières, J, Ferrini, M, Fisher, M, Fliser, D, Fras, Z, Gaita, D, Giampaoli, S, Gielen, S, Graham, I, Jennings, C, Jorgensen, T, Kautzky-Willer, A, Kavousi, M, Koenig, W, Konradi, A, Kotecha, D, Landmesser, U, Lettino, M, Lewis, B, Linhart, A, Lochen, M, Makrilakis, K, Mancia, G, Marques-Vidal, P, Mcevoy, J, Mcgreavy, P, Merkely, B, Neubeck, L, Nielsen, J, Perk, J, Petersen, S, Petronio, A, Piepoli, M, Pogosova, N, Prescott, E, Ray, K, Reiner, Z, Richter, D, Rydén, L, Shlyakhto, E, Sitges, M, Sousa-Uva, M, Sudano, I, Tiberi, M, Touyz, R, Ungar, A, Verschuren, W, Wiklund, O, Wood, D, Zamorano, J, Visseren, FLJ, Smulders, YM, Koskinas, KC, Boavida, JM, Davos, CH, Franco, OH, Hobbs, FDR, Jankowska, EA, Tsioufis, KP, van Gelder, IC, Aamodt, AH, Borger, MA, Ference, BA, Lewis, BS, Lochen, ML, McEvoy, JW, McGreavy, P, Nielsen, JC, Petersen, SE, Petronio, AS, Pogosova, NG, Prescott, EIB, Ray, KK, Richter, DJ, Touyz, RM, Verschuren, WMM, Zamorano, JL, Visseren, F, Mach, F, Smulders, Y, Carballo, D, Koskinas, K, Bäck, M, Benetos, A, Biffi, A, Boavida, J, Capodanno, D, Cosyns, B, Crawford, C, Davos, C, Desormais, I, Di Angelantonio, E, Franco, O, Halvorsen, S, Hobbs, F, Hollander, M, Jankowska, E, Michal, M, Sacco, S, Sattar, N, Tokgozoglu, L, Tonstad, S, Tsioufis, K, van Dis, I, van Gelder, I, Wanner, C, Williams, B, De Backer, G, Regitz-Zagrosek, V, Aamodt, A, Abdelhamid, M, Aboyans, V, Albus, C, Asteggiano, R, Borger, M, Brotons, C, Celutkiene, J, Cifkova, R, Cikes, M, Cosentino, F, Dagres, N, De Backer, T, De Bacquer, D, Delgado, V, Den Ruijter, H, Dendale, P, Drexel, H, Falk, V, Fauchier, L, Ference, B, Ferrières, J, Ferrini, M, Fisher, M, Fliser, D, Fras, Z, Gaita, D, Giampaoli, S, Gielen, S, Graham, I, Jennings, C, Jorgensen, T, Kautzky-Willer, A, Kavousi, M, Koenig, W, Konradi, A, Kotecha, D, Landmesser, U, Lettino, M, Lewis, B, Linhart, A, Lochen, M, Makrilakis, K, Mancia, G, Marques-Vidal, P, Mcevoy, J, Mcgreavy, P, Merkely, B, Neubeck, L, Nielsen, J, Perk, J, Petersen, S, Petronio, A, Piepoli, M, Pogosova, N, Prescott, E, Ray, K, Reiner, Z, Richter, D, Rydén, L, Shlyakhto, E, Sitges, M, Sousa-Uva, M, Sudano, I, Tiberi, M, Touyz, R, Ungar, A, Verschuren, W, Wiklund, O, Wood, D, Zamorano, J, Visseren, FLJ, Smulders, YM, Koskinas, KC, Boavida, JM, Davos, CH, Franco, OH, Hobbs, FDR, Jankowska, EA, Tsioufis, KP, van Gelder, IC, Aamodt, AH, Borger, MA, Ference, BA, Lewis, BS, Lochen, ML, McEvoy, JW, McGreavy, P, Nielsen, JC, Petersen, SE, Petronio, AS, Pogosova, NG, Prescott, EIB, Ray, KK, Richter, DJ, Touyz, RM, Verschuren, WMM, and Zamorano, JL

Published
2022

7. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice

Author

Visseren, F. L. J., Mach, F., Smulders, Y. M., Carballo, D., Koskinas, K. C., Back, M., Benetos, A., Biffi, A., Boavida, J. -M., Capodanno, D., Cosyns, B., Crawford, C., Davos, C. H., Desormais, I., DI Angelantonio, E., Franco, O. H., Halvorsen, S., Hobbs, F. D. R., Hollander, M., Jankowska, E. A., Michal, M., Sacco, S., Sattar, N., Tokgozoglu, L., Tonstad, S., Tsioufis, K. P., Van DIs, I., Van Gelder, I. C., Wanner, C., Williams, B., De Backer, G., Regitz-Zagrosek, V., Aamodt, A. H., Abdelhamid, M., Aboyans, V., Albus, C., Asteggiano, R., Borger, M. A., Brotons, C., Ielutkiene, J., Cifkova, R., Cikes, M., Cosentino, F., Dagres, N., De Backer, T., De Bacquer, D., Delgado, V., Den Ruijter, H., Dendale, P., Drexel, H., Falk, V., Fauchier, L., Ference, B. A., Ferrieres, J., Ferrini, M., Fisher, M., Fliser, D., Fras, Z., Gaita, D., Giampaoli, S., Gielen, S., Graham, I., Jennings, C., Jorgensen, T., Kautzky-Willer, A., Kavousi, M., Koenig, W., Konradi, A., Kotecha, D., Landmesser, U., Lettino, M., Lewis, B. S., Linhart, A., Lochen, M. -L., Makrilakis, K., Mancia, G., Marques-Vidal, P., Mcevoy, J. W., Mcgreavy, P., Merkely, B., Neubeck, L., Nielsen, J. C., Perk, J., Petersen, S. E., Petronio, A. S., Piepoli, M., Pogosova, N. G., Prescott, E. I. B., Ray, K. K., Reiner, Z., Richter, D. J., Ryden, L., Shlyakhto, E., Sitges, M., Sousa-Uva, M., Sudano, I., Tiberi, M., Touyz, R. M., Ungar, A., Verschuren, W. M. M., Wiklund, O., Wood, D., Zamorano, J. L., Crawford, C. A., Franco Duran, O. H., Richard Hobbs, F. D., Dis, I. V., Group, ESC Scientific Document, Clinical sciences, Cardio-vascular diseases, and Cardiology

Subjects
medicine.medical_specialty, Epidemiology, Population, air pollution, population, Guidelines, blood pressure, climate change, diabetes, healthy lifestyle, lifetime benefit, lifetime risk, lipids, nutrition, personalized, prevention, psychosocial factors, risk estimation, risk management, shared decision-making, smoking, stepwise approach, Risk Assessment, Humans, Primary Prevention, Risk Factors, Cardiovascular Diseases, Diabetes mellitus, medicine, Intensive care medicine, education, 610 Medicine & health, Risk management, education.field_of_study, business.industry, medicine.disease, Clinical Practice, Blood pressure, guidelines, Heart failure, Lifetime risk, Disease prevention, Cardiology and Cardiovascular Medicine, business, Stepwise approach, 360 Social problems & social services
Abstract

These are the clinical practice guidelines from the European Society of Cardiology on cardiovascular disease prevention in clinical practice, from 2021.

Published
2022

11. Improving translational research in sex-specific effects of comorbidities and risk factors in ischaemic heart disease and cardioprotection: Position Paper and Recommendations of the ESC Working Group on Cellular Biology of the Heart

Author

Onderzoek Vrouw Hart & Vaatziekten, Circulatory Health, Onderzoek Cardiovasculair Reg. Med., Regenerative Medicine and Stem Cells, Team Medisch, Perrino, C, Ferdinandy, P, Bøtker, H E, Brundel, B J J M, Collins, P, Davidson, S M, den Ruijter, H M, Engel, F B, Gerdts, E, Girao, H, Gyöngyösi, M, Hausenloy, D J, Lecour, S, Madonna, R, Marber, M, Murphy, E, Pesce, M, Regitz-Zagrosek, V, Sluijter, J P G, Steffens, S, Gollmann-Tepeköylü, C, Van Laake, L W, Van Linthout, S, Schulz, R, Ytrehus, K, Onderzoek Vrouw Hart & Vaatziekten, Circulatory Health, Onderzoek Cardiovasculair Reg. Med., Regenerative Medicine and Stem Cells, Team Medisch, Perrino, C, Ferdinandy, P, Bøtker, H E, Brundel, B J J M, Collins, P, Davidson, S M, den Ruijter, H M, Engel, F B, Gerdts, E, Girao, H, Gyöngyösi, M, Hausenloy, D J, Lecour, S, Madonna, R, Marber, M, Murphy, E, Pesce, M, Regitz-Zagrosek, V, Sluijter, J P G, Steffens, S, Gollmann-Tepeköylü, C, Van Laake, L W, Van Linthout, S, Schulz, R, and Ytrehus, K

Published
2021

16. 2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy

Author

Regitz-Zagrosek, V, Roos-Hesselink, JW, Bauersachs, J, Blomström-Lundqvist, C, Cífková, R, De Bonis, M, Iung, B, Johnson, MR, Kintscher, U, Kranke, P, Lang, IM, Morais, J, Pieper, PG, Presbitero, P, Price, S, Rosano, GMC, Seeland, U, Simoncini, T, Swan, L, Warnes, CA, Deaton, C, Simpson, IA, Aboyans, V, Agewall, S, Barbato, E, Calda, P, Coca, A, Coman, IM, De Backer, J, Delgado, V, Di Salvo, G, Fitzsimmons, S, Fitzsimons, D, Garbi, M, Gevaert, S, Hindricks, G, Jondeau, G, Kluin, J, Lionis, C, McDonagh, TA, Meier, P, Moons, P, Pantazis, A, Piepoli, MF, Rocca, B, Roffi, M, Rosenkranz, S, Sarkozy, A, Shlyakhto, E, Silversides, CK, Sliwa, K, Sousa-Uva, M, Tamargo, J, Thorne, S, Van de Velde, M, Williams, B, Zamorano, JL, Windecker, S, Bueno, H, Collet, J-P, Dean, V, Gaemperli, O, Jüni, P, Katus, HA, Knuuti, J, Lancellotti, P, Leclercq, C, Ponikowski, P, Richter, DJ, Hammoudi, N, Piruzyan, A, Mascherbauer, J, Samadov, F, Prystrom, A, Pasquet, A, Caluk, J, Gotcheva, N, Skoric, B, Heracleous, H, Vejlstrup, N, Maser, M, Kaaja, RJ, Srbinovska-Kostovska, E, Mounier-Vehier, C, Vakhtangadze, T, Rybak, K, Giannakoulas, G, Kiss, RG, Thrainsdottir, IS, Erwin, RJ, Porter, A, Geraci, G, Ibrahimi, P, Lunegova, O, Mintale, I, Kadri, Z, Benlamin, H, Barysiene, J, Banu, CA, Caruana, M, Gratii, C, Haddour, L, Bouma, BJ, Estensen, M-E, Hoffman, P, Petris, AO, Moiseeva, O, Bertelli, L, Tesic, BV, Dubrava, J, Koželj, M, Prieto-Arévalo, R, Furenäs, E, Schwerzmann, M, Mourali, MS, Ozer, N, Mitchenko, O, Nelson-Piercy, C, Regitz-Zagrosek, V., Roos-Hesselink, J. W., Bauersachs, J., Blomstrom-Lundqvist, C., Cifkova, R., De Bonis, M., Iung, B., Johnson, M. R., Kintscher, U., Kranke, P., Lang, I. M., Morais, J., Pieper, P. G., Presbitero, P., Price, S., Rosano, G. M. C., Seeland, U., Simoncini, T., Swan, L., Warnes, C. A., Regitz-Zagrosek, Vera, Roos-Hesselink, Jolien W, Bauersachs, Johann, Blomström-Lundqvist, Carina, Cífková, Renata, De Bonis, Michele, Iung, Bernard, Johnson, Mark Richard, Kintscher, Ulrich, Kranke, Peter, Lang, Irene Marthe, Morais, Joao, Pieper, Petronella G, Presbitero, Patrizia, Price, Susanna, Rosano, Giuseppe MC, Seeland, Ute, Simoncini, Tommaso, Swan, Lorna, Warnes, Carole A, and Cardiology

Subjects
Counseling, Prenatal Diagnosi, 030204 cardiovascular system & hematology, Guideline, Cardiovascular, 0302 clinical medicine, Pregnancy, Prenatal Diagnosis, 030212 general & internal medicine, 1102 Cardiorespiratory Medicine and Haematology, Societies, Medical, Risk assessment, Advisory Committee, Advisory Committees, Cardiology, Cardiovascular Agents, Europe, Female, Humans, Poland, Pregnancy Complications, Cardiovascular, Practice Guidelines as Topic, valvular heart disease, Cardiovascular disease, Management, Hypertension, Drug therapy, Cardiology and Cardiovascular Medicine, Arrhythmia, Human, medicine.medical_specialty, Settore BIO/14 - FARMACOLOGIA, Cardiomyopathy, Heart failure, Cardiovascular therapy, Pulmonary hypertension, Aortic pathology, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Medical, medicine, Cardiovascular diagnosis, Intensive care medicine, Congenital heart disease, Pharmacology, business.industry, ta3121, medicine.disease, Valvular heart disease, Pregnancy Complications, Cardiovascular System & Hematology, Cardiovascular Agent, Societies, business
Published
2019

17. Peripartum management of hypertension: a position paper of the ESC Council on Hypertension and the European Society of Hypertension

Author

Cífková, R. Johnson, M.R. Kahan, T. Brguljan, J. Williams, B. Coca, A. Manolis, A. Thomopoulos, C. Borghi, C. Tsioufis, C. Parati, G. Sudano, I. Mcmanus, R.J. Van Den Born, B.-J.H. Regitz-Zagrosek, V. De Simone, G.

Subjects
reproductive and urinary physiology
Abstract

Hypertensive disorders are the most common medical complications in the peripartum period associated with a substantial increase in morbidity and mortality. Hypertension in the peripartum period may be due to the continuation of pre-existing or gestational hypertension, de novo development of pre-eclampsia or it may be also induced by some drugs used for analgesia or suppression of postpartum haemorrhage. Women with severe hypertension and hypertensive emergencies are at high risk of life-threatening complications, therefore, despite the lack of evidence-based data, based on expert opinion, antihypertensive treatment is recommended. Labetalol intravenously and methyldopa orally are then the two most frequently used drugs. Short-acting oral nifedipine is suggested to be used only if other drugs or iv access are not available. Induction of labour is associated with improved maternal outcome and should be advised for women with gestational hypertension or mild pre-eclampsia at 37 weeks' gestation. This position paper provides the first interdisciplinary approach to the management of hypertension in the peripartum period based on the best available evidence and expert consensus. © The Author(s) 2019.

Published
2020

19. ESC Core Curriculum for the General Cardiologist (2013)

Author

Gillebert, Thierry C., Brooks, Nicholas, Fontes-Carvalho, Ricardo, Fras, Zlatko, Gueret, Pascal, Lopez-Sendon, Jose, Salvador, Maria Jesus, van den Brink, Renee B. A., Smiseth, Otto A., Griebenow, Reinhard, Kearney, Peter, Vahanian, Alec, Bauersachs, J., Bax, J., Burri, H., Caforio, A.L.P., Calvo, F., Charron, P., Ertl, G., Flachskampf, F., Giannuzzi, P., Gibbs, S., Gonçalves, L., González-Juanatey, J.R., Hall, J., Herpin, D., Iaccarino, G., Iung, B., Kitsiou, A., Lancellotti, P., McDonough, T., Monsuez, J.J., Nuñez, I.J., Plein, S., Porta-Sánchez, A., Priori, S., Price, S., Regitz-Zagrosek, V., Reiner, Z., Ruilope, L.M., Schmid, J.P., Sirnes, P. A., Sousa-Ouva, M., Stępińska, J., Szymanski, C., Taggart, D., Tendera, M., Tokgözog[Combining Caron]lu, L., Trindade, P., Zeppenfeld, K., Joubert, L., and Carrera, C.

Published
2013
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23. Age-dependent cardiac remodelling – role of sex hormones

Author

Haider, A, primary, Bengs, S, additional, Warnock, G, additional, Akhmedov, A, additional, Kozerke, S, additional, Kwiatkowski, G, additional, Mueller Herde, A, additional, Kraemer, S.D, additional, Weber, B, additional, Schibli, R, additional, Mu, L, additional, Kaufmann, P.A, additional, Regitz-Zagrosek, V, additional, Ametamey, S.M, additional, and Gebhard, C, additional

Published
2020
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31. Ergebnisse einer Befragung von Absolvierenden des Modell- und Regelstudiengangs Medizin der Charité Berlin zu gendermedizinischem Wissen und Kompetenzen [Bericht über Forschungsergebnisse]

Author

Ludwig, S., Peters, H., Regitz-Zagrosek, V., and Seeland, U.

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Problemstellung/Ziele: Mit der Einführung des Modellstudiengangs Medizin gehören gendermedizinisches Wissen und die Berücksichtigung von Geschlechterunterschieden bei der Prävention, Diagnostik und Therapie von Erkrankungen zu den prüfungsrelevanten Inhalten. Das Ziel war[zum vollständigen Text gelangen Sie über die oben angegebene URL], Jahrestagung der Gesellschaft für Medizinische Ausbildung (GMA)

Published
2018

32. Right heart function in impaired left ventricular diastolic function: 2D speckle tracking echocardiography-based and Doppler tissue imaging-based analysis of right atrial and ventricular function

Author

Brand, A., Bathe, M., Oertelt-Prigione, S., Seeland, U., Rucke, M., Regitz-Zagrosek, V., Stangl, K., Knebel, F., Stangl, V., Dreger, H., Brand, A., Bathe, M., Oertelt-Prigione, S., Seeland, U., Rucke, M., Regitz-Zagrosek, V., Stangl, K., Knebel, F., Stangl, V., and Dreger, H.

Abstract

Item does not contain fulltext, AIM: The aim of our study was to describe right atrial (RA) and right ventricular (RV) function, assessed by Doppler tissue imaging and 2D speckle tracking echocardiography (2DSTE), in women with signs of early impaired left ventricular diastolic function (DD). METHODS AND RESULTS: In a cross-sectional trial, standard parameters of diastolic and right heart function were investigated in 438 women of the Berlin Female Risk Evaluation (BEFRI) study. In a subset of women, average peak systolic RA strain (RAS), as well as the average peak systolic RV strain of the free wall (RVS free wall) and of all RV segments (average RV strain; RVS Avg), was analyzed using 2DSTE. Compared to women with normal diastolic function (DD0), RAS, RVS free wall and RVS Avg were significantly reduced in DD (43.1% +/- 11.9%, -26.7% +/- 5.6%, and -23.3% +/- 3.5% in DD0; vs 35.1% +/- 10.4%, -23.9% +/- 5.5%, and -20.6% +/- 3.8% in DD; P < .01). Peak RV myocardial velocity (RV-IVV) and acceleration during isovolumetric contraction (RV-IVA) were markedly higher in DD (15.0 +/- 3.9 cm/s and 3.1 +/- 1.0 m/s(2) in DD vs 11.9 +/- 3.2 cm/s and 2.8 +/- 0.8 m/s(2) in DD0; P < .05). RAS and RV-IVV were significantly associated with DD after adjustment to age, BMI, and left atrial strain in multivariate regression analysis. CONCLUSION: Systolic right heart function is significantly altered in DD. DTI as well as 2DSTE constitute sensitive echocardiographic tools that enable the diagnosis of impaired right heart mechanics in early-staged DD.

Published
2018

34. Exome-wide association study reveals novel susceptibility genes to sporadic dilated cardiomyopathy

Author

Esslinger, U, Garnier, S, Korniat, A, Proust, C, Kararigas, G, Mueller-Nurasyid, M, Empana, J-P, Morley, MP, Perret, C, Stark, K, Bick, AG, Prasad, SK, Kriebel, J, Li, J, Tiret, L, Strauch, K, O'Regan, DP, Marguiles, KB, Seidman, JG, Boutouyrie, P, Lacolley, P, Jouven, X, Hengstenberg, C, Komajda, M, Hakonarson, H, Isnard, R, Arbustini, E, Grallert, H, Cook, SA, Seidman, CE, Regitz-Zagrosek, V, Cappola, TP, Charron, P, Cambien, F, Villard, E, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Helmholtz Zentrum München = German Research Center for Environmental Health, Ludwig-Maximilians-Universität München (LMU), German Center for Cardiovascular Research (DZHK), Berlin Institute of Health (BIH), Munich Heart Alliance [Munich, Allemagne] (MHA), Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), University of Pennsylvania, University of Regensburg, Harvard Medical School [Boston] (HMS), Royal Brompton Hospital, German Center for Diabetes Research - Deutsches Zentrum für Diabetesforschung [Neuherberg] (DZD), Children’s Hospital of Philadelphia (CHOP ), Imperial College London, Howard Hughes Medical Institute [Chevy Chase] (HHMI), Howard Hughes Medical Institute (HHMI), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), Fondazione IRCCS Policlinico San Matteo [Pavia], Università degli Studi di Pavia = University of Pavia (UNIPV), National Heart Centre Singapore (NHCS), Duke-NUS Medical School [Singapore], Howard Hughes Medical Institute [Boston] (HHMI), Howard Hughes Medical Institute (HHMI)-Harvard Medical School [Boston] (HMS), Hôpital Ambroise Paré [AP-HP], LACOLLEY, Patrick, Ludwig-Maximilians University [Munich] (LMU), Technische Universität München = Technical University of Munich (TUM), Garnier, Sophie, Fondation Leducq, National Institute for Health Research, British Heart Foundation, Wellcome Trust, and Department of Health

Subjects
[SDV]Life Sciences [q-bio], PROTEIN, Biochemistry, Heat Shock Response, Myofibrils, Animal Cells, Medicine and Health Sciences, Cellular Stress Responses, ARCHITECTURE, Computer-Aided Drug Design, COMMON VARIANTS, Genomics, Precipitation Techniques, Multidisciplinary Sciences, [SDV] Life Sciences [q-bio], DIFFERENTIATION, Cell Processes, Science & Technology - Other Topics, HEART-FAILURE, Medicine, HSPB7, Cellular Types, Anatomy, Cardiomyopathies, Research Article, Sarcomeres, Drug Research and Development, General Science & Technology, Science, Cardiology, Muscle Tissue, Research and Analysis Methods, MD Multidisciplinary, Genetics, Genome-Wide Association Studies, Immunoprecipitation, SKELETAL-MUSCLES, Pharmacology, Muscle Cells, Science & Technology, MUTATIONS, Biology and Life Sciences, Computational Biology, Proteins, Human Genetics, Cell Biology, Genome Analysis, Co-Immunoprecipitation, Chaperone Proteins, Biological Tissue, Genetic Loci, Drug Design, FHOD3, P19CL6 CELLS
Abstract

International audience; Aims: Dilated cardiomyopathy (DCM) is an important cause of heart failure with a strong familial component. We performed an exome-wide array-based association study (EWAS) to assess the contribution of missense variants to sporadic DCM.Methods and results: 116,855 single nucleotide variants (SNVs) were analyzed in 2796 DCM patients and 6877 control subjects from 6 populations of European ancestry. We confirmed two previously identified associations with SNVs in BAG3 and ZBTB17 and discovered six novel DCM-associated loci (Q-value

Published
2017

37. Sex differences in cardiovascular disease : Impact on care and outcomes

Author

Humphries, K. H., Izadnegandar, M., Sedlak, T., Saw, J., Johnston, Nina, Schenck-Gustafsson, K., Shah, R. U., Regitz-Zagrosek, V., Grewal, J., Vaccarino, V., Wei, J., Merz, C. N. Bairey, Humphries, K. H., Izadnegandar, M., Sedlak, T., Saw, J., Johnston, Nina, Schenck-Gustafsson, K., Shah, R. U., Regitz-Zagrosek, V., Grewal, J., Vaccarino, V., Wei, J., and Merz, C. N. Bairey

Published
2017
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38. Gynecological Practice Represents the Ideal Setting for Early Opportunistic Cardiovascular Prevention: A Cross-Sectional Survey in an Urban Female Population

Author

Oertelt-Prigione, S., Ruecke, M., Seeland, U., Regitz-Zagrosek, V., Oertelt-Prigione, S., Ruecke, M., Seeland, U., and Regitz-Zagrosek, V.

Abstract

Item does not contain fulltext, BACKGROUND: Cardiovascular diseases are the main cause of mortality for women worldwide, yet their impact is frequently underestimated. To raise awareness for preventative lifestyle measures other contacts with the healthcare system should be exploited. We analyzed access patterns to other healthcare specialists and population screening measures to identify options for opportunistic counseling on cardiovascular risk. MATERIALS AND METHODS: We enrolled 1062 randomly selected German urban women aged 25-74 years in 2012-2013, divided into 5 age bands. Women were asked about sociodemographic characteristics, clinical and gynecological history, physician attendance patterns, screening behavior and primary sources of health and preventative information, and clinical examination attendance. RESULTS: Obstetrician/gynecologists (OBGYN) were the most frequently consulted physicians within the last 12 months (75.3%), more than general practitioners (GP; 74%). Attendance rates to OBGYNs were not affected by education or income, solely a body mass index (BMI) >30 associated with significantly reduced rates of attendance (OR = 0.4, CI 95% = 0.17-0.78, p = 0.009). Women with low to medium Framingham risk scores were more likely to attend an OBGYN than a GP if they attended only one specialist. Attendance of population screening measures is limited (<60% for all offers) and hence unsuitable for systematic cardiovascular counseling. CONCLUSION: OBGYN represent a very popular and equitable healthcare contact for women of all ages and this could be exploited for cardiovascular screening. Furthermore, the strikingly different sources of health information reported highlight a need for improved health communication and differentiation of messages.

Published
2017

39. Integration von Diversity-Aspekten in die klinischen Module des Modellstudiengangs Medizin der Charité Berlin

Author

Ludwig, S, Oertelt-Prigione, S, Seeland, U, Regitz-Zagrosek, V, and Peters, H

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Fragestellung/Zielsetzung: Im Rahmen der Einführung des Modellstudiengangs Medizin der Charité-Universitätsmedizin Berlin konnten Diversity, insbesondere geschlechterspezifische Aspekte, erfolgreich in die Module des 1.-8. Semesters integriert werden. Das Ziel war nun die Entwicklung[zum vollständigen Text gelangen Sie über die oben angegebene URL], Jahrestagung der Gesellschaft für Medizinische Ausbildung (GMA)

Published
2016
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40. Cardiomyocyte-specific overexpression of estrogen receptor beta improves survival and cardiac function after myocardial infarction in female and male mice

Author

Schuster, I., Mahmoodzadeh, S., Dworatzek, E., Jaisser, F., Messaoudi, S., Morano, I., and Regitz-Zagrosek, V.

Subjects
Cardiovascular and Metabolic Diseases, hormones, hormone substitutes, and hormone antagonists
Abstract

BACKGROUND: Estrogen receptor beta (ERbeta) activation has been shown to be cardioprotective, but the involved cell types and mechanisms are not understood. To investigate whether ERbeta restricted to cardiomyocytes contributes to observed cardioprotection, we tested the effects of a cardiomyocyte-specific ERbeta overexpression (ERbeta-OE) on survival, cardiac remodelling and function after myocardial infarction (MI) and studied potentially involved molecular pathways. METHODS AND RESULTS: Female and male mice with cardiomyocyte-specific ERbeta-OE and wild type (WT) littermates were subjected to chronic anterior coronary artery ligation or sham surgery. Two weeks after MI, ERbeta-OE mice showed improved survival (100 and 83% vs 76 and 58% in WT females and males respectively). ERbeta-OE was associated with attenuated left ventricular (LV) dilatation, smaller increase in heart weight, less lung congestion at similar MI size, and improved systolic and diastolic function in both sexes. We identified two potential pathways for ERbeta mediated myocardial protection. First, male and female ERbeta-OE mice had a lower reduction of SERCA2a expression after MI, suggesting less reduction in diastolic Ca2+-reuptake into sarcoplasmic reticulum post MI. Second, male ERbeta-OE revealed attenuated cardiac fibrosis in the remote LV tissue and expression of fibrosis markers Col I, Col III, periostin, and miR21. CONCLUSIONS: Cardiomyocyte-specific ERbeta-OE improved survival associated with reduced maladaptive remodelling, improved cardiac function and less heart failure development after MI in both sexes. These effects seem to be related, at least in part, to a better maintenance of Ca2+-cycling in both sexes and a lower induction of cardiac fibrosis in males after MI.

Published
2016

41. Gender in cardiovascular diseases: impact on clinical manifestations, management, and outcomes

Author

EUGenMed, Cardiovascular Clinical Study Group (), Regitz-Zagrosek, V., Oertelt-Prigione, S., Prescott, E., Franconi, F., Gerdts, E., Foryst-Ludwig, A., Maas, A.H., Kautzky-Willer, A., Knappe-Wegner, D., Kintscher, U., Ladwig, K.-H., Schenck-Gustafsson, K., and Stangl, V.

Subjects
Male, medicine.medical_specialty, Pathology, Drug-Related Side Effects and Adverse Reactions, Heart Diseases, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], MEDLINE, Disease, 030204 cardiovascular system & hematology, Affect (psychology), 03 medical and health sciences, Sex Factors, 0302 clinical medicine, Epidemiology, medicine, Humans, 030212 general & internal medicine, business.industry, Cardiovascular Agents, Human development (humanity), Sexual hormones, Treatment Outcome, Hypertension, Needs assessment, Female, Cardiology and Cardiovascular Medicine, Vascular function, business, Needs Assessment, Clinical psychology
Abstract

In the vast majority of cardiovascular diseases (CVDs), there are well-described differences between women and men in epidemiology, pathophysiology, clinical manifestations, effects of therapy, and outcomes.1–3 These differences arise on one hand from biological differences among women and men, which are called sex differences. They are due to differences in gene expression from the sex chromosomes and subsequent differences in sexual hormones leading to differences in gene expression and function in the CV system, e.g. in vascular function and NO signalling, in myocardial remodelling under stress, or metabolism of drugs by sex-specific cytochrome expression. Sex differences are frequently reproducible in animal models. In contrast, gender differences are unique to the human. They arise from sociocultural processes, such as different behaviours of women and men; exposure to specific influences of the environment; different forms of nutrition, lifestyle, or stress; or attitudes towards treatments and prevention. These are equally important for CVDs. Both sex and gender (S&G) influence human development ( Figure 1 ). Since it is almost impossible to distinguish properly between effects of S&G in the medical field, the EUGenMed writing group decided to discuss both of them together and to use the term S&G for all medical relevant differences between women and men in the present review. Figure 1 Interaction between sex and gender during lifetime: societal conditions (upper) as well as biological facts (lower) affect germ cells, the newborn, the adult, and the development of disease in women and men. In its current research framework programme ‘Horizon 2020’, the EU calls for the inclusion of the gender dimension into biomedical research since ‘it helps improve the scientific quality …

Published
2016

43. HIT Poster session 2P479Strain concordance in a real-world setting: experience in our laboratory after equipment upgradeP4803D echocardiography is a fast-learning and reliable method for the measurements of left atrial volumesP481Echocardiographic parameters associated with long-term appropriate antiarrhythmic therapies in cardiac resynchronization therapy defibrillator patientsP482Noninvasively measured global wasted myocardial work allows for quantitative assessment of typical left ventricular mechanical dyssynchrony pattern in patients with left bundle branch blockP483The impact of adherence to physical exercise on the improvement of cardiovascular remodeling and metabolic status in healthy untrained postmenopausal womenP484The impact of the latest chamber quantification recommendations on the prediction of left atrial appendage thrombus presenceP485The cardiac-enriched miRNAs plasma levels (miR-1, miR-133a, miR-499) reflect the impaired left ventricular systolic function and correlate with cardiac necrosis markers in early phase of NSTE-ACSP486Acute regional myocardial deformation changes in patients with severe aortic stenosis and preserved ejection fraction after isolated aortic valve replacementP487Left ventricular rotational deformation in asymptomatic patients with chronic aortic regurgitation and normal left ventricular ejection fraction P488The appropriate use of transthoracic echocardiography for the exclusion of infective endocarditisP489In patients with hypertrophic cardiomyopathy, left ventricular mass and shape by three-dimensional echocardiography are related with dynamic obstruction and functional capacityP490Mitral leaflet sizing in hypertrophic cardiomyopathy: impact of method and timingP491Echocardiographic predictors of atrial fibrillation in obese womenP492Echocardiographic risk factors for 30 day mortality after the hybrid procedure for hypoplastic left heart syndromeP493Left ventricular mass is an independent predictor of coronary flow reserve: insights from a single centre stress echo cohortP494Transesophageal echocardigoraphy uner conscious sedation for guiding cryoballoon pulmonary vein isolation in paroxysmal atrial fibrillation - the safety and feasibility studyP495Transesophageal echocardigoraphy under conscious sedation for guiding cryoballoon pulmonary vein isolation in paroxysmal atrial fibrillation - the safety and feasibility studyP496Three-dimensional trans-esophageal echocardiography assessment of the immediate morphological changes of the mitral annulus after percutaneous mitral edge-to-edge repairP497Clinical value of global and regional longitudinal strain in prediction of myocardial ischemia in asymptomatic diabetes type 2 patientsP499Comparison of prognostic operative risk impact on the global longitudinal strain right ventricle (GLS RV) and tricuspid annular plane systolic excursion (TAPSE) values in patients with ischemic cardioP498Right heart function in early diastolic dysfunction: 2D speckle-tracking echocardiography-based assessment of right atrial and right ventricular functionP500 Comparison of 2D, 3D transesophageal echocardiography and computed tomography during the assessment of left atrial appendage closure

Author

Cueva Recalde, JF., primary, Velcea, A., primary, Aguiar Rosa, S., primary, Surkova, E., primary, Bucciarelli, V., primary, Kupczynska, K., primary, Miskowiec, D., primary, Reskovic Luksic, V., primary, Verseckaite, R., primary, Jillott, N., primary, Muraru, D., primary, Borizanova, A., primary, Caroli, S., primary, Guerreiro, S., primary, Mahmoud, HM., primary, Peovska Mitevska, I., primary, Babukov, R., primary, Brecht, A., primary, Garcia-Sanchez, MJ., primary, Gayan Ordas, J., additional, Lacambra Blasco, I., additional, Mihaila, S., additional, Andronic, AA., additional, Marcu, S., additional, Vinereanu, D., additional, Galrinho, A., additional, Branco, L., additional, Timoteo, A., additional, Cunha, P., additional, Lousinha, A., additional, Valente, B., additional, Pereira Silva, T., additional, Oliveira, M., additional, Cruz Ferreira, R., additional, Aalen, J., additional, Samset, E., additional, Bidviene, J., additional, Aruta, P., additional, Romeo, G., additional, Sambugaro, F., additional, Badano, LP., additional, Muraru, D., additional, Bianco, F., additional, Di Blasio, A., additional, Izzicupo, P., additional, Ghinassi, B., additional, Napolitano, G., additional, Di Baldassarre, A., additional, Gallina, S., additional, Michalski, B., additional, Miskowiec, D., additional, Kasprzak, JD., additional, Lipiec, P., additional, Kupczynska, K., additional, Simiera, M., additional, Wejner-Mik, P., additional, Wierzbowska-Drabik, K., additional, Ojrzanowski, M., additional, Pasalic, M., additional, Separovic Hanzevacki, J., additional, Mizariene, V., additional, Montvilaite, A., additional, Unikaite, R., additional, Bieseviciene, M., additional, Jurkevicius, R., additional, Wilson, S., additional, Marotta, C., additional, Calore, C., additional, Surkova, E., additional, Palermo, C., additional, Iliceto, S., additional, Kinova, E., additional, Kundurzhiev, T., additional, Goudev, A., additional, Bellsham-Revell, HR., additional, Bell, AJ., additional, Miller, OI., additional, Simpson, JM., additional, Raposo, L., additional, Andrade, MJ., additional, Horta, E., additional, Reis, C., additional, Almeida, M., additional, Mendes, M., additional, Qawoq, HD., additional, Zycinski, P., additional, Wcislo, T., additional, Abdel Raouf, O., additional, Kheir, A., additional, Halawa, S., additional, Al-Ghamdi, M., additional, Ghabashi, A., additional, Srbinovska, E., additional, Antova, E., additional, Bosevski, M., additional, Bazilev, VV., additional, Bartosh, FL., additional, Bathe, M., additional, Oertelt-Prigione, S., additional, Seeland, U., additional, Regitz-Zagrosek, V., additional, Baumann, G., additional, Stangl, K., additional, Stangl, V., additional, Knebel, F., additional, Dreger, H., additional, Barreiro-Perez, M., additional, Arribas-Jimenez, A., additional, Martin-Garcia, A., additional, Diaz-Pelaez, E., additional, Rama-Merchan, JC., additional, Cruz-Gonzalez, I., additional, and Sanchez, PL., additional

Published
2016
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44. ESC core curriculum for the general cardiologist (2013)

Author

European Society of Cardiology, Committee for Education, Authors/Task Force Members, Gillebert, Tc, Brooks, N, Fontes-Carvalho, R, Fras, Z, Gueret, P, Lopez-Sendon, J, Salvador, Mj, van den Brink RB, Smiseth, Oa, Observer on behalf of the UEMS (Cardiology Section), Griebenow, R, Review, Coordinators, Kearney, P, Vahanian, A, Contributors and reviewers, Bauersachs, J, Bax, J, Burri, H, Caforio, A, Calvo, F, Charron, P, Ertl, G, Flachskampf, F, Giannuzzi, P, Gibbs, S, Gonçalves, L, González-Juanatey, Jr, Hall, J, Herpin, D, Iaccarino, G, Iung, B, Kitsiou, A, Lancellotti, P, Mcdonough, T, Monsuez, Jj, Nuñez, Ij, Plein, S, Porta-Sánchez, A, Priori, S, Price, S, Regitz-Zagrosek, V, Reiner, Z, Ruilope, Lm, Schmid, Jp, Sirnes, Pa, Sousa-Ouva, M, Stepinska, J, Szymanski, C, Taggart, D, Tendera, M, Tokgözoglu, L, Trindade, P, Zeppenfeld, K, Esc, Staff, Joubert, L, Carrera, C., Gillebert, T. C., Brooks, N., Fontes-Carvalho, R., Fras, Z., Gueret, P., Lopez-Sendon, J., Salvador, M. J., Van Den Brink, R. B. A., Smiseth, O. A., Griebenow, R., Kearney, P., Vahanian, A., Bauersachs, J., Bax, J., Burri, H., Caforio, A. L. P., Calvo, F., Charron, P., Ertl, G., Flachskampf, F., Giannuzzi, P., Gibbs, S., Goncalves, L., Gonzalez-Juanatey, J. R., Hall, J., Herpin, D., Iaccarino, G., Iung, B., Kitsiou, A., Lancellotti, P., Mcdonough, T., Monsuez, J. J., Nunez, I. J., Plein, S., Porta-Sanchez, A., Priori, S., Price, S., Regitz-Zagrosek, V., Reiner, Z., Ruilope, L. M., Schmid, J. P., Sirnes, P. A., Sousa-Ouva, M., Stepinska, J., Szymanski, C., Taggart, D., Tendera, M., Tokgozoglu, L., Trindade, P., Zeppenfeld, K., Joubert, L., and Carrera, C.

Subjects
health care facilities, manpower, and services, Teaching method, Behaviours, Certification, Sports Medicine, GUIDELINES, RECOMMENDATIONS, Electrocardiography, Pregnancy, Competence, CME, Medicine and Health Sciences, Heart Team, Medical History Taking, health care economics and organizations, Schools, Medical, Societies, Medical, Skills, Rehabilitation, VERSION 2009, ASSOCIATION, Objectives, EUROPEAN-SOCIETY, Europe, Obstetrics, Knowledge, CARDIOVASCULAR-DISEASE, Pharmacology, Clinical, Cardiology, HEART-FAILURE, Female, Clinical Competence, Curriculum, Cardiology and Cardiovascular Medicine, medicine.medical_specialty, Attitude of Health Personnel, Genetics, Medical, education, Heart Centre, Specialty, MEDLINE, Expertise, DIAGNOSIS, Core curriculum, Education, health services administration, Internal medicine, medicine, Internal Medicine, MANAGEMENT, Humans, Training, cardiovascular diseases, Competence (human resources), Physical Examination, Preventive healthcare, business.industry, Teaching, Subspecialties, Cardiopulmonary Resuscitation, Cardiac Imaging Techniques, Education, Medical, Graduate, Attitudes, Preventive Medicine, business, End-terms, TASK-FORCE
Abstract

The previous Core Curriculum for the General Cardiologist defined a model for cardiology training in Europe and it has been adopted as the standard for regulating training, for access to the specialty (certification), and for revalidation in several countries.1 During the last 5 years we have witnessed profound changes in cardiological practice. The work of both hospital and independent cardiologists has been better integrated with that of general practitioners. It has taken into account the requirements of national authorities, re-imbursement organizations, and hospital administrations. Cardiologists face changing patient expectations. General cardiologists, interventional …

Published
2013

45. Gender in cardiovascular diseases: impact on clinical manifestations, management, and outcomes

Author

Regitz-Zagrosek, V., Oertelt, S., Prescott, E., Franconi, F., Gerdts, E., Foryst-Ludwig, A., Maas, A.H.E.M., Kautzky-Willer, A., Knappe-Wegner, D., Kintscher, U., Ladwig, K.H., Schenck-Gustafsson, K., Stangl, V., Regitz-Zagrosek, V., Oertelt, S., Prescott, E., Franconi, F., Gerdts, E., Foryst-Ludwig, A., Maas, A.H.E.M., Kautzky-Willer, A., Knappe-Wegner, D., Kintscher, U., Ladwig, K.H., Schenck-Gustafsson, K., and Stangl, V.

Abstract

Item does not contain fulltext

Published
2016

46. Integrating topics of sex and gender into medical curricula : lessons from the international community

Author

Miller, V, Kararigas, G, Seeland, U, Regitz-Zagrosek, V, Kublickiene, K, Einstein, Gillian, Casanova, R, Legato, M, Miller, V, Kararigas, G, Seeland, U, Regitz-Zagrosek, V, Kublickiene, K, Einstein, Gillian, Casanova, R, and Legato, M

Abstract

In the era of individualized medicine, training future scientists and health-care providers in the principles of sex- and gender-based differences in health and disease is critical in order to optimize patient care. International successes to incorporate these concepts into medical curricula can provide a template for others to follow. Methodologies and resources are provided that can be adopted and adapted to specific needs of other institutions and learning situations.

Published
2016
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47. Molecular mechanism regulating myosin and cardiac functions by ELC

Author

Lossie, J., Köhncke, C., Mahmoodzadeh, S., Steffen, W., Canepari, M., Maffei, M., Taube, M., Larchevêque, O., Baumert, P., Haase, H., Bottinelli, R., Regitz-Zagrosek, V., and Morano, I.

Subjects
Cardiovascular and Metabolic Diseases, Function and Dysfunction of the Nervous System
Abstract

The essential myosin light chain (ELC) is involved in modulation of force generation of myosin motors and cardiac contraction, while its mechanism of action remains elusive. We hypothesized that ELC could modulate myosin stiffness which subsequently determines its force production and cardiac contraction. We therefore generated heterologous transgenic mouse (TgM) strains with cardiomyocyte-specific expression of ELC with human ventricular ELC (hVLC-1; TgM(hVLC-1)) or E56G-mutated hVLC-1 (hVLC-1(E56G); TgM(E56G)). hVLC-1 or hVLC-1(E56G) expression in TgM was around 39% and 41%, respectively of total VLC-1. Laser trap and in vitro motility assays showed that stiffness and actin sliding velocity of myosin with hVLC-1 prepared from TgM(hVLC-1) (1.67pN/nm and 2.3{my}m/s, respectively) were significantly higher than myosin with hVLC-1(E56G) prepared from TgM(E56G) (1.25pN/nm and 1.7{my}m/s, respectively) or myosin with mouse VLC-1 (mVLC-1) prepared from C57/BL6 (1.41 pN/nm and 1.5+-0.03 {my}m/s, respectively). Maximal left ventricular pressure development of isolated perfused hearts in vitro prepared from TgM(hVLC-1) (80.0mmHg) were significantly higher than hearts from TgM(E56G) (66.2mmHg) or C57/BL6 (59.3+-3.9 mmHg). These findings show that ELCs decreased myosin stiffness, in vitro motility, and thereby cardiac functions in the order hVLC-1 > hVLC-1(E56G) ≈ mVLC-1. They also suggest a molecular pathomechanism of cardiomyopathies caused by hVLC-1 mutations.

Published
2014

48. HIT Poster session 1P154Preclinical diastolic dysfunction is related to impaired endothelial function in patients with chronic kidney diseaseP155Early detection of left atrial and left ventricular abnormalities in hypertensive and obese womenP156Right ventricle preserved systolic function irrespective of right ventricular hypertrophy and disease severity in anderson fabry diseaseP157Left atrial volume and function in patients undergoing percutaneous mitral valve repairP158Impact of left ventricular dysfunction on outcomes of patients undergoing direct TAVI with a self-expanding bioprosthesisP159Anatomic Doppler spectrum – retrospective spectral tissue Doppler from ultra high frame rate tissue Doppler imaging for evaluation of tissue deformationP160Phasic dynamics of ischaemic mitral regurgitation after primary coronary intervention in acute myocardial infarction: serial echocardiographic assessment from emergency room to long-term follow-upP161Reproducibility of 3DE RV volumes - novel insights at a regional levelP162Pulmonary vascular capacitance as assessed by echocardiography in pulmonary arterial hypertensionP163Three-dimensional endocardial area strain: a novel parameter for quantitative assessment of global left ventricular systolic functionP164Role of exercise hemodynamics assessed by echocardiography on symptom reduction after MitraClipP165Early identification of ventricular dysfunction in patients with juvenile systemic sclerosisP166Heart failure with and without preserved ejection fraction - the role of biomarkers in the aspect of global longitudinal strainP167Complex systolic deformation of aortic root: insights from two dimensional speckle tracking imageP168Volumetric and deformational imaging usind 2d strain and 3d echocardiography in patients with pulmonary hypertensionP169Influence of pressure load and right ventricular morphology and function on tricuspid regurgitation in pulmonary arterial hypertensionP170Left ventricular myocardial diastolic deformation analysis by 2D speckle tracking echocardiography and relationship with conventional diastolic parameters in chronic aortic regurgitationP171Extracellular volume, and not native T1 time, distinguishes diffuse fibrosis in dilated or hypertrophic cardiomyopathy at 3TP172Left atrial strain is significantly reduced in arterial hypertensionP173Symptomatic severe secondary mitral regurgitation: LV enddiastolic diameter (LVEDD) as preferable parameter for risk stratificationP174Left ventricular mechanics in isolated left bundle branch block at rest and when exercising: exploration of the concept of conductive cardiomyopathyP175Assessment of myocardial scar by 2D contrast echocardiographyP176Chronic pericarditis - expression of a rare disease: Erdheim Chester diseaseP177Aortic arch mechanics with two-dimensional speckle tracking echocardiography to estimate the left ventricular remodelling in hypertensive patientsP178Strain analysis by tissue doppler imaging: comparison of conventional manual measurement with a semi-automated approachP179Distribution of extravascular lung water in heart failure patients assessed by lung ultrasoudP180Surrogate markers for obstructive coronary artery diseaseP181LA deformation and LV longitudinal strain by two-dimensional speckle tracking echocardiography as predictors of postoperative AF development after aortic valve replacement in ASP182Left ventricular diastolic dysfunction in type 2 diabetic patients with non alcoholic fatty liver diseaseP183Myocardial strain by speckle-tracking and evaluation of 3D ejection fraction in drug-induced cardiotoxicity's approach in breast cancer

Author

Gevaert, AB, primary, Borizanova, A, primary, Graziani, F, primary, Galuszka, O M, primary, Stathogiannis, K, primary, Lervik Nilsen, L C, primary, Nishino, S, primary, Willis, J, primary, Venner, C, primary, Luo, XX, primary, Van De Heyning, C M, primary, Castaldi, B, primary, Michalski, BW, primary, Wang, TL, primary, Aktemur, T, primary, Dorlet, S, primary, Verseckaite, R, primary, Amzulescu, MS, primary, Brecht, A, primary, Brand, M, primary, Galli, E, primary, Murzilli, R, primary, Bica, R, primary, Teixeira, R, primary, Schmid, J, primary, Miglioranza, MH, primary, Cherneva, ZH, primary, Gheghici, S, primary, Pernigo, M, primary, Rafael, D, primary, Van Craenenbroeck, AH, additional, Shivalkar, B, additional, Lemmens, K, additional, Vrints, CJ, additional, Van Craenenbroeck, EM, additional, Somleva, D, additional, Zlatareva- Gronkova, N, additional, Kinova, E, additional, Goudev, A, additional, Camporeale, A, additional, Pieroni, M, additional, Pedicino, D, additional, Laurito, MP, additional, Verrecchia, E, additional, Lanza, GA, additional, Manna, R, additional, Crea, F, additional, Reinthaler, M, additional, Rutschow, S, additional, Gross, M, additional, Landmesser, U, additional, Kasner, M, additional, Toutouzas, K, additional, Drakopoulou, M, additional, Latsios, G, additional, Synetos, A, additional, Kaitozis, O, additional, Trantalis, G, additional, Mastrokostopoulos, A, additional, Kotronias, R, additional, Tousoulis, D, additional, Brekke, BB, additional, Aase, SA, additional, Lonnebakken, MT, additional, Stensvag, D, additional, Amundsen, B, additional, Torp, H, additional, Stoylen, A, additional, Watanabe, N, additional, Kimura, T, additional, Nakama, T, additional, Furugen, M, additional, Koiwaya, H, additional, Ashikaga, K, additional, Kuriyama, N, additional, Shibata, Y, additional, Augustine, DX, additional, Knight, D, additional, Sparey, J, additional, Coghlan, G, additional, Easaw, J, additional, Huttin, O, additional, Voilliot, D, additional, Mercy, M, additional, Villemin, T, additional, Olivier, A, additional, Mandry, D, additional, Chaouat, A, additional, Juilliere, Y, additional, Selton-Suty, C, additional, Fang, F, additional, Li, S, additional, Zhang, ZH, additional, Yu, CM, additional, Bertrand, PB, additional, De Maeyer, C, additional, De Bock, D, additional, Paelinck, BP, additional, Claeys, MJ, additional, Reffo, E, additional, Balzarin, M, additional, Zulian, F, additional, Milanesi, O, additional, Miskowiec, D, additional, Kupczynska, K, additional, Peczek, L, additional, Nawrot, B, additional, Lipiec, P, additional, Kasprzak, JD, additional, Li, H, additional, Jin, XY, additional, Poci, N, additional, Kaymaz, C, additional, Venner, C, additional, Manenti, V, additional, Carillo, S, additional, Chabot, F, additional, Mizariene, V, additional, Rimkeviciute, D, additional, Bieseviciene, M, additional, Jonkaitiene, R, additional, Jurkevicius, R, additional, Roy, C, additional, Slimani, A, additional, Boileau, L, additional, De Meester, C, additional, Vancraeynest, D, additional, Pasquet, A, additional, Vanoverschelde, JL, additional, Pouleur, AC, additional, Gerber, BL, additional, Oertelt-Prigione, S, additional, Seeland, U, additional, Ruecke, M, additional, Regitz-Zagrosek, V, additional, Stangl, V, additional, Knebel, F, additional, Laux, D, additional, Roeing, J, additional, Butz, T, additional, Christ, M, additional, Grett, M, additional, Wennemann, R, additional, Trappe, H- J, additional, Fournet, M, additional, Leclercq, C, additional, Samset, E, additional, Daubert, J-C, additional, Donal, E, additional, Leo, LA, additional, Pasotti, E, additional, Klersy, C, additional, Moccetti, T, additional, Faletra, FF, additional, Dobre, D, additional, Darmon, S, additional, Dumitrescu, S, additional, Calistru, P, additional, Monteiro, R, additional, Ribeiro, M, additional, Garcia, J, additional, Cardim, N, additional, Goncalves, L, additional, Kaufmann, R, additional, Grubler, MR, additional, Verheyen, N, additional, Weidemann, F, additional, Binder, JS, additional, Santanna, RT, additional, Rover, MM, additional, Leiria, T, additional, Kalil, R, additional, Picano, E, additional, Gargani, L, additional, Kuneva, ZK, additional, Vasilev, DV, additional, Ianula, R, additional, Dasoveanu, M, additional, Calin, C, additional, Homentcovsci, C, additional, Siliste, R, additional, Bergamini, C, additional, Mantovani, A, additional, Bonapace, S, additional, Lipari, P, additional, Barbieri, E, additional, Bonora, E, additional, Targher, G, additional, Camarozano, AC, additional, Pereira Da Cunha, CL, additional, Padilha, SL, additional, Souza, AM, additional, and Freitas, AKE, additional

Published
2015
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49. CYP2J2 overexpression protects against arrhythmia susceptibility in cardiac hypertrophy

Author

Westphal, C., Spallek, B., Konkel, A., Marko, L., Qadri, F., Degraff, L.M., Schubert, C., Bradbury, J.A., Regitz-Zagrosek, V., Falck, J.R., Zeldin, D.C., Müller, D.N., Schunck, W.H., and Fischer, R.

Subjects
Cardiovascular and Metabolic Diseases, cardiovascular system
Abstract

Maladaptive cardiac hypertrophy predisposes one to arrhythmia and sudden death. Cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) promote anti-inflammatory and antiapoptotic mechanisms, and are involved in the regulation of cardiac Ca(2+)-, K(+)- and Na(+)-channels. To test the hypothesis that enhanced cardiac EET biosynthesis counteracts hypertrophy-induced electrical remodeling, male transgenic mice with cardiomyocyte-specific overexpression of the human epoxygenase CYP2J2 (CYP2J2-TG) and wildtype littermates (WT) were subjected to chronic pressure overload (transverse aortic constriction, TAC) or {beta}-adrenergic stimulation (isoproterenol infusion, ISO). TAC caused progressive mortality that was higher in WT (42% over 8 weeks after TAC), compared to CYP2J2-TG mice (6%). In vivo electrophysiological studies, 4 weeks after TAC, revealed high ventricular tachyarrhythmia inducibility in WT (47% of the stimulation protocols), but not in CYP2J2-TG mice (0%). CYP2J2 overexpression also enhanced ventricular refractoriness and protected against TAC-induced QRS prolongation and delocalization of left ventricular connexin-43. ISO for 14 days induced high vulnerability for atrial fibrillation in WT mice (54%) that was reduced in CYP-TG mice (17%). CYP2J2 overexpression also protected against ISO-induced reduction of atrial refractoriness and development of atrial fibrosis. In contrast to these profound effects on electrical remodeling, CYP2J2 overexpression only moderately reduced TAC-induced cardiac hypertrophy and did not affect the hypertrophic response to {beta}-adrenergic stimulation. These results demonstrate that enhanced cardiac EET biosynthesis protects against electrical remodeling, ventricular tachyarrhythmia, and atrial fibrillation susceptibility during maladaptive cardiac hypertrophy.

Published
2013

50. ESC guidelines on the management of cardiovascular diseases during pregnancy

Author

Regitz-Zagrosek, V, Bomstrom Lundqvist, C, Borghi, C, Cifkova, R, Ferreira, RJ, Foidart, JM, Gibbs, JSR, Gohlke-Bearvolf, C, Gorenek, B, Lund, B, Kirby, M, Maas, AHEM, Morais, J, Nihoyannopolous, P, Pieper, R, Presbitero, P, Roos - Hesselink, Jolien, Schaufelberger, M, Seeland, U, Torracca, L, and Cardiology

Subjects
SDG 3 - Good Health and Well-being
Published
2012

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