1,127 results on '"Rajaraman P"'
Search Results
2. Weak Poincar\'e Inequalities, Simulated Annealing, and Sampling from Spherical Spin Glasses
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Huang, Brice, Mohanty, Sidhanth, Rajaraman, Amit, and Wu, David X.
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Mathematics - Probability ,Condensed Matter - Disordered Systems and Neural Networks ,Computer Science - Data Structures and Algorithms ,Mathematical Physics - Abstract
There has been a recent surge of powerful tools to show rapid mixing of Markov chains, via functional inequalities such as Poincar\'e inequalities. In many situations, Markov chains fail to mix rapidly from a worst-case initialization, yet are expected to approximately sample from a random initialization. For example, this occurs if the target distribution has metastable states, small clusters accounting for a vanishing fraction of the mass that are essentially disconnected from the bulk of the measure. Under such conditions, a Poincar\'e inequality cannot hold, necessitating new tools to prove sampling guarantees. We develop a framework to analyze simulated annealing, based on establishing so-called weak Poincar\'e inequalities. These inequalities imply mixing from a suitably warm start, and simulated annealing provides a way to chain such warm starts together into a sampling algorithm. We further identify a local-to-global principle to prove weak Poincar\'e inequalities, mirroring the spectral independence and localization schemes frameworks for analyzing mixing times of Markov chains. As our main application, we prove that simulated annealing samples from the Gibbs measure of a spherical spin glass for inverse temperatures up to a natural threshold, matching recent algorithms based on algorithmic stochastic localization. This provides the first Markov chain sampling guarantee that holds beyond the uniqueness threshold for spherical spin glasses, where mixing from a worst-case initialization is provably slow. As an ingredient in our proof, we prove bounds on the operator norm of the covariance matrix of spherical spin glasses in the full replica-symmetric regime. Additionally, we resolve questions related to the mixing of Glauber dynamics in the ferromagnetic Potts model from a uniform monochromatic coloring, and sampling using data-based initializations., Comment: 101 pages
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- 2024
3. Fully Dynamic (\Delta+1) Coloring Against Adaptive Adversaries
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Behnezhad, Soheil, Rajaraman, Rajmohan, and Wasim, Omer
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Computer Science - Data Structures and Algorithms - Abstract
Over the years, there has been extensive work on fully dynamic algorithms for classic graph problems that admit greedy solutions. Examples include $(\Delta+1)$ vertex coloring, maximal independent set, and maximal matching. For all three problems, there are randomized algorithms that maintain a valid solution after each edge insertion or deletion to the $n$-vertex graph by spending $\polylog n$ time, provided that the adversary is oblivious. However, none of these algorithms work against adaptive adversaries whose updates may depend on the output of the algorithm. In fact, even breaking the trivial bound of $O(n)$ against adaptive adversaries remains open for all three problems. For instance, in the case of $(\Delta+1)$ vertex coloring, the main challenge is that an adaptive adversary can keep inserting edges between vertices of the same color, necessitating a recoloring of one of the endpoints. The trivial algorithm would simply scan all neighbors of one endpoint to find a new available color (which always exists) in $O(n)$ time. In this paper, we break this linear barrier for the $(\Delta+1)$ vertex coloring problem. Our algorithm is randomized, and maintains a valid $(\Delta+1)$ vertex coloring after each edge update by spending $\widetilde{O}(n^{8/9})$ time with high probability., Comment: Full Version of a SODA '25 paper
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- 2024
4. Longitudinal Imaging-Based Clusters in Former Smokers of the COPD Cohort Associate with Clinical Characteristics: The SubPopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS)
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Zou C, Li F, Choi J, Haghighi B, Choi S, Rajaraman PK, Comellas AP, Newell Jnr JD, Lee CH, Barr RG, Bleecker E, Cooper CB, Couper D, Han M, Hansel NN, Kanner RE, Kazerooni EA, Kleerup EC, Martinez FJ, O'Neal W, Paine III R, Rennard SI, Smith BM, Woodruff PG, Hoffman EA, and Lin CL
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computed tomography ,emphysema ,functional small airway disease ,longitudinal clustering ,Diseases of the respiratory system ,RC705-779 - Abstract
Chunrui Zou,1,2 Frank Li,2,3 Jiwoong Choi,1,4 Babak Haghighi,5 Sanghun Choi,6 Prathish K Rajaraman,1,2 Alejandro P Comellas,7 John D Newell Jnr,8 Chang Hyun Lee,8,9 R Graham Barr,10 Eugene Bleecker,11 Christopher B Cooper,12 David Couper,13 Meilan Han,14 Nadia N Hansel,15 Richard E Kanner,16 Ella A Kazerooni,17 Eric C Kleerup,18 Fernando J Martinez,19 Wanda O’Neal,20 Robert Paine III,16 Stephen I Rennard,21 Benjamin M Smith,22,23 Prescott G Woodruff,24 Eirc A Hoffman,3,7,8 Ching-Long Lin1– 3,8 1Department of Mechanical Engineering, University of Iowa, Iowa City, IA, USA; 2IIHR-Hydroscience & Engineering, University of Iowa, Iowa City, IA, USA; 3Department of Biomedical Engineering, University of Iowa, Iowa City, IA, USA; 4Department of Internal Medicine, School of Medicine, University of Kansas, Kansas City, KS, USA; 5Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; 6School of Mechanical Engineering, Kyungpook National University, Daegu, Republic of Korea; 7Department of Internal Medicine, University of Iowa, Iowa City, IA, USA; 8Department of Radiology, University of Iowa, Iowa City, IA, USA; 9Department of Radiology, College of Medicine, Seoul National University, Seoul, Republic of Korea; 10Mailman School of Public Health, Columbia University, New York, NY, USA; 11Department of Medicine, The University of Arizona, Tucson, AZ, USA; 12Department of Physiology, UCLA, Los Angeles, CA, USA; 13Department of Biostatistics, University of North Carolina, Chapel Hill, NC, USA; 14Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA; 15School of Medicine, Johns Hopkins, Baltimore, MD, USA; 16School of Medicine, University of Utah, Salt Lake City, UT, USA; 17Department of Radiology, University of Michigan, Ann Arbor, MI, USA; 18Department of Medicine, UCLA, Los Angeles, CA, USA; 19Weill Cornell Medicine, Cornell University, New York, NY, USA; 20School of Medicine, University of North Carolina, Chapel Hill, NC, USA; 21Department of Internal Medicine, University of Nebraska College of Medicine, Omaha, NE, USA; 22Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA; 23Department of Medicine, McGill University Health Centre Research Institute, Montreal, Canada; 24Department of Medicine, University of California at San Francisco, San Francisco, CA, USACorrespondence: Ching-Long Lin 2406 Seamans Center for the Engineering Art and Science, Iowa City, IA, 52242, USATel +1 319 335 5673Email ching-long-lin@uiowa.eduPurpose: Quantitative computed tomography (qCT) imaging-based cluster analysis identified clinically meaningful COPD former-smoker subgroups (clusters) based on cross-sectional data. We aimed to identify progression clusters for former smokers using longitudinal data.Patients and Methods: We selected 472 former smokers from SPIROMICS with a baseline visit and a one-year follow-up visit. A total of 150 qCT imaging-based variables, comprising 75 variables at baseline and their corresponding progression rates, were derived from the respective inspiration and expiration scans of the two visits. The COPD progression clusters identified were then associated with subject demography, clinical variables and biomarkers.Results: COPD severities at baseline increased with increasing cluster number. Cluster 1 patients were an obese subgroup with rapid progression of functional small airway disease percentage (fSAD%) and emphysema percentage (Emph%). Cluster 2 exhibited a decrease of fSAD% and Emph%, an increase of tissue fraction at total lung capacity and airway narrowing over one year. Cluster 3 showed rapid expansion of Emph% and an attenuation of fSAD%. Cluster 4 demonstrated severe emphysema and fSAD and significant structural alterations at baseline with rapid progression of fSAD% over one year. Subjects with different progression patterns in the same cross-sectional cluster were identified by longitudinal clustering.Conclusion: qCT imaging-based metrics at two visits for former smokers allow for the derivation of four statistically stable clusters associated with unique progression patterns and clinical characteristics. Use of baseline variables and their progression rates enables identification of longitudinal clusters, resulting in a refinement of cross-sectional clusters.Keywords: computed tomography, emphysema, functional small airway disease, longitudinal clustering
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- 2021
5. Association between in vitro susceptibility and clinical outcomes in fungal keratitis.
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Lu, Louisa, Prajna, N, Lalitha, Prajna, Rajaraman, Revathi, Srinivasan, Muthiah, Arnold, Benjamin, Acharya, Nisha, Lietman, Thomas, and Rose-Nussbaumer, Jennifer
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Antifungals ,Fungal keratitis ,Microbial susceptibility ,Minimum inhibitory concentration ,Therapeutic penetrating keratoplasty - Abstract
PURPOSE: The purpose of this study was to assess the association between antifungal susceptibility as measured by minimum inhibitory concentration (MIC) and clinical outcomes in fungal keratitis. METHODS: This pre-specified secondary analysis of the Mycotic Ulcer Treatment Trial II (MUTT II) involved patients with filamentous fungal keratitis presenting to Aravind Eye Hospitals in South India. Antifungal susceptibility testing for natamycin and voriconazole was performed on all samples with positive fungal culture results according to Clinical and Laboratory Standards Institute Guidelines. The relationship between MIC and clinical outcomes of best-corrected visual acuity, infiltrate or scar size, corneal perforation, need for therapeutic penetrating keratoplasty, and time to re-epithelialization were assessed. RESULTS: We obtained MIC values from 141 patients with fungal keratitis. The most commonly cultured organisms were Aspergillus (46.81%, n = 66) and Fusarium (44.68%, n = 63) species. Overall, there was no association between antifungal MICs and clinical outcomes. Subgroup analysis revealed that among Fusarium-positive cases, higher voriconazole MIC was correlated with worse three-month best-corrected visual acuity (p = 0.03), increased need for therapeutic penetrating keratoplasty (p = 0.04), and time to re-epithelialization (p = 0.03). No significant correlations were found among Aspergillus-positive cases. There were no significant correlations found between natamycin MIC and clinical outcomes among organism subgroups. CONCLUSIONS: Decreased susceptibility to voriconazole was associated with increased odds of requiring a therapeutic penetrating keratoplasty in Fusarium-positive cases. Susceptibility to natamycin was not associated with any of the measured outcomes.
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- 2024
6. Competitive Capacitated Online Recoloring
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Rajaraman, Rajmohan and Wasim, Omer
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Computer Science - Data Structures and Algorithms ,Computer Science - Distributed, Parallel, and Cluster Computing - Abstract
In this paper, we revisit the online recoloring problem introduced recently by Azar et al. In online recoloring, there is a fixed set $V$ of $n$ vertices and an initial coloring $c_0: V\rightarrow [k]$ for some $k\in \mathbb{Z}^{>0}$. Under an online sequence $\sigma$ of requests where each request is an edge $(u_t,v_t)$, a proper vertex coloring $c$ of the graph $G_t$ induced by requests until time $t$ needs to be maintained for all $t$; i.e., for any $(u,v)\in G_t$, $c(u)\neq c(v)$. The objective is to minimize the total weight of vertices recolored for the sequence $\sigma$. We obtain the first competitive algorithms for capacitated online recoloring and fully dynamic recoloring. Our first set of results is for $2$-recoloring using algorithms that are $(1+\varepsilon)$-resource augmented where $\varepsilon\in (0,1)$ is an arbitrarily small constant. Our main result is an $O(\log n)$-competitive deterministic algorithm for weighted bipartite graphs, which is asymptotically optimal in light of an $\Omega(\log n)$ lower bound that holds for an unbounded amount of augmentation. We also present an $O(n\log n)$-competitive deterministic algorithm for fully dynamic recoloring, which is optimal within an $O(\log n)$ factor in light of a $\Omega(n)$ lower bound that holds for an unbounded amount of augmentation. Our second set of results is for $\Delta$-recoloring in an $(1+\varepsilon)$-overprovisioned setting where the maximum degree of $G_t$ is bounded by $(1-\varepsilon)\Delta$ for all $t$, and each color assigned to at most $(1+\varepsilon)\frac{n}{\Delta}$ vertices, for an arbitrary $\varepsilon > 0$. Our main result is an $O(1)$-competitive randomized algorithm for $\Delta = O(\sqrt{n/\log n})$. We also present an $O(\Delta)$-competitive deterministic algorithm for $\Delta \le \varepsilon n/2$. Both results are asymptotically optimal., Comment: Full version of an ESA '24 paper
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- 2024
7. Interaction of driven 'cold' electron plasma wave with thermal bulk mediated by spatial ion inhomogeneity
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Pandey, Sanjeev Kumar and Ganesh, Rajaraman
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Physics - Plasma Physics ,Physics - Computational Physics - Abstract
Using high resolution Vlasov - Poisson simulations, evolution of driven ``cold" electron plasma wave (EPW) in the presence of stationary inhomogeneous background of ions is studied. Mode coupling dynamics between ``cold'' EPW with phase velocity $v_{\phi}$ greater than thermal velocity i.e $v_{\phi} \gg v_{thermal}$ and its inhomogeneity induced sidebands is illustrated as an initial value problem. In driven cases, formation of BGK like phase space structures corresponding to sideband modes due to energy exchange from primary mode to bulk particles via wave-wave and wave-particle interactions leading to particle trapping is demonstrated for inhomogeneous plasma. Qualitative comparison studies between initial value perturbation and driven problem is presented, which examines the relative difference in energy transfer time between the interacting modes. Effect of variation in background ion inhomogeneity amplitude as well as ion inhomogeneity scale length on the driven EPWs is reported.
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- 2024
8. Transformers on Markov Data: Constant Depth Suffices
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Rajaraman, Nived, Bondaschi, Marco, Ramchandran, Kannan, Gastpar, Michael, and Makkuva, Ashok Vardhan
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Computer Science - Machine Learning ,Computer Science - Computation and Language ,Computer Science - Information Theory ,Statistics - Machine Learning - Abstract
Attention-based transformers have been remarkably successful at modeling generative processes across various domains and modalities. In this paper, we study the behavior of transformers on data drawn from \kth Markov processes, where the conditional distribution of the next symbol in a sequence depends on the previous $k$ symbols observed. We observe a surprising phenomenon empirically which contradicts previous findings: when trained for sufficiently long, a transformer with a fixed depth and $1$ head per layer is able to achieve low test loss on sequences drawn from \kth Markov sources, even as $k$ grows. Furthermore, this low test loss is achieved by the transformer's ability to represent and learn the in-context conditional empirical distribution. On the theoretical side, our main result is that a transformer with a single head and three layers can represent the in-context conditional empirical distribution for \kth Markov sources, concurring with our empirical observations. Along the way, we prove that \textit{attention-only} transformers with $O(\log_2(k))$ layers can represent the in-context conditional empirical distribution by composing induction heads to track the previous $k$ symbols in the sequence. These results provide more insight into our current understanding of the mechanisms by which transformers learn to capture context, by understanding their behavior on Markov sources., Comment: 29 pages, 10 figures
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- 2024
9. The Role of Helical and Non-Helical Drives on the evolution of Self-Consistent Dynamos
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Biswas, Shishir and Ganesh, Rajaraman
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Physics - Plasma Physics ,Astrophysics - Astrophysics of Galaxies ,Physics - Computational Physics ,Physics - Fluid Dynamics - Abstract
In the self-consistent dynamo limit, the magnetic feedback on the velocity field is sufficiently strong to induce a change in the topology of the magnetic field. Consequently, the magnetic energy reaches a state of non-linear saturation. Here, we investigate the role played by helical and non-helical drives in the triggering and the eventual saturation of a self-consistent dynamo. Evidence of small-scale dynamo (SSD) activity is found for both helical and non-helical forcing, driven at the largest possible scale. Based on the spectrum analysis, we find that the evolution of kinetic energy follows Kolmogorov's $k^-{\frac{5}{3}}$ law while that of magnetic energy follows Kazantsev's $k^{\frac{3}{2}}$ scaling. Also, we have verified that the aforementioned scalings remain valid for various magnetic Prandtl numbers (Pm). Statistical analysis is found to support our numerical finds.
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- 2024
10. A Starter's Kit for Concentric Tube Robots
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Bonofiglio, Kalina, Wang, Wenpeng, Wilke, Ethan R., Rajaraman, Adri, and Fichera, Loris
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Computer Science - Robotics - Abstract
Concentric Tube Robots (CTRs) have garnered significant interest within the surgical robotics community because of their flexibility, dexterity, and ease of miniaturization. However, mastering the unique kinematics and design principles of CTRs can be challenging for newcomers to the field. In this paper, we present an educational kit aimed at lowering the barriers to entry into concentric tube robot research. Our goal is to provide accessible learning resources for CTRs, bridging the knowledge gap between traditional robotic arms and these specialized devices. The proposed kit includes (1) An open-source design and assembly instructions for an economical (cost of materials $\approx$ 700 USD) modular CTR; (2) A set of self-study materials to learn the basics of CTR modeling and control, including automatically-graded assignments. To evaluate the effectiveness of our educational kit, we conducted a human subjects study involving first-year graduate students in engineering. Over a four-week period, participants -- none of whom had any prior knowledge of concentric tube robots -- successfully built their first CTR using the provided materials, implemented the robot's kinematics in MATLAB, and conducted a tip-tracking experiment with an optical tracking device. Our findings suggest that the proposed kit facilitates learning and hands-on experience with CTRs, and furthermore, it has the potential to help early-stage graduate students get rapidly started with CTR research. By disseminating these resources, we hope to broaden participation in concentric tube robot research to a wider a more diverse group of researchers.
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- 2024
11. Instabilities of Gauged Q-Balls
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Rajaraman, Arvind
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High Energy Physics - Theory - Abstract
We present the first analytical calculation that shows that perturbations with angular dependence can lead to an instability in gauged Q-balls. We find an explicit condition on the parameters for the Q-ball to become unstable. We compare our predictions to the numerical calculation in Kinach et al., and show agreement, including a correct prediction of the instability/stability of the two parameter points analyzed in that paper., Comment: 12 pages
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- 2024
12. Effects of ganaxolone on non-seizure outcomes in CDKL5 Deficiency Disorder: Double-blind placebo-controlled randomized trial.
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Downs, J, Jacoby, P, Specchio, N, Cross, H, Amin, S, Bahi-Buisson, N, Rajaraman, Rajsekar, Suter, B, Devinsky, O, Aimetti, A, Busse, G, Olson, H, Demarest, S, Benke, T, and Pestana-Knight, E
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Anti-Seizure medication ,CDKL5 deficiency disorder ,Epilepsy ,Patient-reported outcomes ,Humans ,Female ,Male ,Double-Blind Method ,Child ,Child ,Preschool ,Adolescent ,Quality of Life ,Young Adult ,Treatment Outcome ,Epileptic Syndromes ,Seizures ,Pregnanolone ,Spasms ,Infantile - Abstract
CDKL5 deficiency disorder (CDD) is a rare developmental and epileptic encephalopathy. Ganaxolone, a neuroactive steroid, reduces the frequency of major motor seizures in children with CDD. This analysis explored the effect of ganaxolone on non-seizure outcomes. Children (2-19 years) with genetically confirmed CDD and ≥ 16 major motor seizures per month were enrolled in a double-blind randomized placebo-controlled trial. Ganaxolone or placebo was administered three times daily for 17 weeks. Behaviour was measured with the Anxiety, Depression and Mood Scale (ADAMS), daytime sleepiness with the Child Health Sleep Questionnaire, and quality of life with the Quality of Life Inventory-Disability (QI-Disability) scale. Scores were compared using ANOVA, adjusted for age, sex, number of anti-seizure mediations, baseline 28-day major motor seizure frequency, baseline developmental skills, and behaviour, sleep or quality of life scores. 101 children with CDD (39 clinical sites, 8 countries) were randomized. Median (IQR) age was 6 (3-10) years, 79.2 % were female, and 50 received ganaxolone. After 17 weeks of treatment, Manic/Hyperactive scores (mean difference 1.27, 95%CI -2.38,-0.16) and Compulsive Behaviour scores (mean difference 0.58, 95%CI -1.14,-0.01) were lower (improved) in the ganaxolone group compared with the placebo group. Daytime sleepiness scores were similar between groups. The total change in QOL score for children in the ganaxolone group was 2.6 points (95%CI -1.74,7.02) higher (improved) than in the placebo group but without statistical significance. Along with better seizure control, children who received ganaxolone had improved behavioural scores in select domains compared to placebo.
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- 2024
13. Epileptic spasms relapse is associated with response latency but not conventional attributes of post-treatment EEG.
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Deckard, Emmi, Sathe, Rujuta, Tabibzadeh, David, Terango, Aria, Groves, Aran, Rajaraman, Rajsekar, Nariai, Hiroki, and Hussain, Shaun
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epileptiform discharges ,infantile spasms ,vigabatrin ,west syndrome ,Humans ,Electroencephalography ,Spasms ,Infantile ,Female ,Male ,Infant ,Recurrence ,Anticonvulsants ,Vigabatrin ,Child ,Preschool ,Risk Factors ,Treatment Outcome ,Cohort Studies - Abstract
OBJECTIVE: Relapse of epileptic spasms after initial treatment of infantile epileptic spasms syndrome (IESS) is common. However, past studies of small cohorts have inconsistently linked relapse risk to etiology, treatment modality, and EEG features upon response. Using a large single-center IESS cohort, we set out to quantify the risk of epileptic spasms relapse and identify specific risk factors. METHODS: We identified all children with epileptic spasms at our center using a clinical EEG database. Using the electronic medical record, we confirmed IESS syndrome classification and ascertained treatment, response, time to relapse, etiology, EEG features, and other demographic factors. Relapse-free survival analysis was carried out using Cox proportional hazards regression. RESULTS: Among 599 children with IESS, 197 specifically responded to hormonal therapy and/or vigabatrin (as opposed to surgery or other second-line treatments). In this study, 41 (21%) subjects exhibited relapse of epileptic spasms within 12 months of response. Longer duration of IESS prior to response (>3 months) was strongly associated with shorter latency to relapse (hazard ratio = 3.11; 95% CI 1.59-6.10; p = 0.001). Relapse was not associated with etiology, developmental status, or any post-treatment EEG feature. SIGNIFICANCE: This study suggests that long duration of IESS before response is the single largest clinical predictor of relapse risk, and therefore underscores the importance of prompt and successful initial treatment. Further study is needed to evaluate candidate biomarkers of epileptic spasms relapse and identify treatments to mitigate this risk. PLAIN LANGUAGE SUMMARY: Relapse of infantile spasms is common after initially successful treatment. With study of a large group of children with infantile spasms, we determined that relapse is linked to long duration of infantile spasms. In contrast, relapse was not associated with the cause of infantile spasms, developmental measures, or EEG features at the time of initial response. Further study is needed to identify tools to predict impending relapse of infantile spasms.
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- 2024
14. Locally Stationary Distributions: A Framework for Analyzing Slow-Mixing Markov Chains
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Liu, Kuikui, Mohanty, Sidhanth, Raghavendra, Prasad, Rajaraman, Amit, and Wu, David X.
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Computer Science - Data Structures and Algorithms ,Mathematics - Probability - Abstract
Many natural Markov chains fail to mix to their stationary distribution in polynomially many steps. Often, this slow mixing is inevitable since it is computationally intractable to sample from their stationary measure. Nevertheless, Markov chains can be shown to always converge quickly to measures that are locally stationary, i.e., measures that don't change over a small number of steps. These locally stationary measures are analogous to local minima in continuous optimization, while stationary measures correspond to global minima. While locally stationary measures can be statistically far from stationary measures, do they enjoy provable theoretical guarantees that have algorithmic implications? We study this question in this work and demonstrate three algorithmic applications of locally stationary measures: 1. We show that Glauber dynamics on the hardcore model can be used to find independent sets of size $\Omega\left(\frac{\log d}{d} \cdot n\right)$ in triangle-free graphs of degree at most $d$. 2. Let $W$ be a symmetric real matrix with bounded spectral diameter and $v$ be a unit vector. Given the matrix $M = \lambda vv^\top + W$ with a planted rank-one spike along vector $v$, for sufficiently large constant $\lambda$, Glauber dynamics on the Ising model defined by $M$ samples vectors $x \in \{\pm 1\}^n$ that have constant correlation with the vector $v$. 3. Let $M = A_{\mathbf{G}} - \frac{d}{n}\mathbf{1}\mathbf{1}^\top$ be a centered version of the adjacency matrix where the graph $\mathbf{G}$ is drawn from a sparse 2-community stochastic block model. We show that for sufficiently large constant signal-to-noise ratio, Glauber dynamics on the Ising model defined by $M$ samples vectors $x \in \{\pm 1\}^n$ that have constant correlation with the hidden community vector $\mathbf{\sigma}$., Comment: 36 pages
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- 2024
15. Fast Mixing in Sparse Random Ising Models
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Liu, Kuikui, Mohanty, Sidhanth, Rajaraman, Amit, and Wu, David X.
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Mathematics - Probability ,Computer Science - Data Structures and Algorithms ,Mathematics - Combinatorics - Abstract
Motivated by the community detection problem in Bayesian inference, as well as the recent explosion of interest in spin glasses from statistical physics, we study the classical Glauber dynamics for sampling from Ising models with sparse random interactions. It is now well-known that when the interaction matrix has spectral diameter less than $1$, Glauber dynamics mixes in $O(n\log n)$ steps. Unfortunately, such criteria fail dramatically for interactions supported on arguably the most well-studied sparse random graph: the Erd\H{o}s--R\'{e}nyi random graph $G(n,d/n)$, due to the presence of almost linearly many outlier eigenvalues of unbounded magnitude. We prove that for the \emph{Viana--Bray spin glass}, where the interactions are supported on $G(n,d/n)$ and randomly assigned $\pm\beta$, Glauber dynamics mixes in $n^{1+o(1)}$ time with high probability as long as $\beta \le O(1/\sqrt{d})$, independent of $n$. We further extend our results to random graphs drawn according to the $2$-community stochastic block model, as well as when the interactions are given by a "centered" version of the adjacency matrix. The latter setting is particularly relevant for the inference problem in community detection. Indeed, we use this to show that Glauber dynamics succeeds at recovering communities in the stochastic block model in a companion paper [LMR+24]. The primary technical ingredient in our proof is showing that with high probability, a sparse random graph can be decomposed into two parts -- a \emph{bulk} which behaves like a graph with bounded maximum degree and a well-behaved spectrum, and a \emph{near-forest} with favorable pseudorandom properties. We then use this decomposition to design a localization procedure that interpolates to simpler Ising models supported only on the near-forest, and then execute a pathwise analysis to establish a modified log-Sobolev inequality., Comment: 67 pages, 4 figures
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- 2024
16. Toward a Theory of Tokenization in LLMs
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Rajaraman, Nived, Jiao, Jiantao, and Ramchandran, Kannan
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Computer Science - Computation and Language ,Computer Science - Machine Learning - Abstract
While there has been a large body of research attempting to circumvent tokenization for language modeling (Clark et al., 2022; Xue et al., 2022), the current consensus is that it is a necessary initial step for designing state-of-the-art performant language models. In this paper, we investigate tokenization from a theoretical point of view by studying the behavior of transformers on simple data generating processes. When trained on data drawn from certain simple $k^{\text{th}}$-order Markov processes for $k > 1$, transformers exhibit a surprising phenomenon - in the absence of tokenization, they empirically fail to learn the right distribution and predict characters according to a unigram model (Makkuva et al., 2024). With the addition of tokenization, however, we empirically observe that transformers break through this barrier and are able to model the probabilities of sequences drawn from the source near-optimally, achieving small cross-entropy loss. With this observation as starting point, we study the end-to-end cross-entropy loss achieved by transformers with and without tokenization. With the appropriate tokenization, we show that even the simplest unigram models (over tokens) learnt by transformers are able to model the probability of sequences drawn from $k^{\text{th}}$-order Markov sources near optimally. Our analysis provides a justification for the use of tokenization in practice through studying the behavior of transformers on Markovian data., Comment: 58 pages, 10 figures
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- 2024
17. Aggregate morphing of self-aligining soft active disks in semi-confined geometry
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Chugh, Anshika, De Karmakar, Soumen, and Ganesh, Rajaraman
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Condensed Matter - Soft Condensed Matter - Abstract
We study the dependence of alignment and confinement on the aggregate morphology of self-aligning soft disks in a planer box geometry confined along y direction. We show that the wall accumulation of aggregates becomes non-uniform upon increase in alignment strength and decrease in box width. The height of these structures is found to be a non-monotonic function of alignment strength. Additionally, we identify two distinct categories of wall aggregates: layered and non-layered structures each exhibiting distinct local structural properties. For non-layered structures, local properties stay nearly constant as we move away from the boundary, while for layered structures, they increase with distance from the boundary. Our analysis shows that active pressure difference is a useful indicator for different aggregate morphologies and the peaks in the pressure curve are indicative of the average and minimum height of the structure.
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- 2024
18. Facilitating Greater Understanding of Trauma-Informed Care in Applied Behavior Analysis: An Introduction to the Special Issue
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Austin, Jennifer L., Rajaraman, Adithyan, and Beaulieu, Lauren
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- 2024
- Full Text
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19. Robust fault analysis in transmission lines using Synchrophasor measurements
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Rajaraman P., Sundaravaradan N.A., Mallikarjuna B., Jaya Bharata Reddy M., and Mohanta D.K.
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Transmission line faults ,Fault analysis ,Phasor measurement units ,Symmetrical components ,Distribution or transmission of electric power ,TK3001-3521 ,Production of electric energy or power. Powerplants. Central stations ,TK1001-1841 - Abstract
Abstract As more electric utilities and transmission system operators move toward the smart grid concept, robust fault analysis has become increasingly complex. This paper proposes a methodology for the detection, classification, and localization of transmission line faults using Synchrophasor measurements. The technique involves the extraction of phasors from the instantaneous three-phase voltages and currents at each bus in the system which are then decomposed into their symmetrical components. These components are sent to the phasor data concentrator (PDC) for real-time fault analysis, which is completed within 2–3 cycles after fault inception. The advantages of this technique are its accuracy and speed, so that fault information may be appropriately communicated to facilitate system restoration. The proposed algorithm is independent of the transmission system topology and displays high accuracy in its results, even with varying parameters such as fault distance, fault inception angle and fault impedance. The proposed algorithm is validated using a three-bus system as well as the Western System Coordinating Council (WSCC) nine bus system. The proposed algorithm is shown to accurately detect the faulted line and classify the fault in all the test cases presented.
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- 2018
- Full Text
- View/download PDF
20. Stability of P2P Networks Under Greedy Peering (Full Version)
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Kiffer, Lucianna and Rajaraman, Rajmohan
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Computer Science - Computer Science and Game Theory ,Computer Science - Networking and Internet Architecture - Abstract
Major cryptocurrency networks have relied on random peering choice rules for making connections in their peer-to-peer networks. Generally, these choices have good properties, particularly for open, permissionless networks. Random peering choices however do not take into account that some actors may choose to optimize who they connect to such that they are quicker to hear about information being propagated in the network. In this paper, we explore the dynamics of such greedy strategies. We study a model in which nodes select peers with the objective of minimizing their average distance to a designated subset of nodes in the network, and consider the impact of several factors including the peer selection process, degree constraints, and the size of the designated subset. The latter is particularly interesting in the context of blockchain networks as generally only a subset of nodes are the propagation source for content. We first analyze an idealized version of the game where each node has full knowledge of the current network and aims to select the $d$ best connections, and prove the existence of equilibria under various model assumptions. Since in reality nodes only have local knowledge based on their peers' behavior, we also study a greedy protocol which runs in rounds, with each node replacing its worst-performing edge with a new random edge. We exactly characterize stability properties of networks that evolve with this peering rule and derive regimes where stability is possible and even inevitable. We also run extensive simulations with this peering rule examining both how the network evolves and how different network parameters affect the stability properties of the network. Our findings generally show that the only stable networks that arise from greedy peering choices are low-diameter and result in disparate performance for nodes in the network.
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- 2024
21. Pseudo-spectral solver versus grid-based solver: A quantitative accuracy test using GMHD3D and PLUTO4.4
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Biswas, Shishir and Ganesh, Rajaraman
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Physics - Computational Physics ,Physics - Fluid Dynamics ,Physics - Plasma Physics - Abstract
We provide a thorough comparison of the GMHD3D code and the PLUTO4.4 code for both two and three-dimensional hydrodynamic and magnetohydrodynamic problems. The open-source finite-volume solver PLUTO4.4 and the in-house developed pseudo-spectral multi-GPU solver GMHD3D both can be used to model the dynamics and turbulent motions of astrophysical plasmas. Although GMHD3D and PLUTO4.4 utilize different implementations, it is found that simulation results for hydrodynamic and magnetohydrodynamic problems, such as the rate of instability growth, 3-dimensional turbulent dynamics, oscillation of kinetic & magnetic energy, and recurrence dynamics, are remarkably similar. However, it is shown that the pseudo spectral solver GMHD3D is significantly more superior than the grid based solver PLUTO4.4 for certain category of physics problems.
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- 2024
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22. Locality is the strongest predictor of expert performance in image-based differentiation of bacterial and fungal corneal ulcers from India.
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Rosenberg, Christopher, Prajna, Venkatesh, Srinivasan, Muthiah, Lalitha, Prajna, Krishnan, Tiru, Rajaraman, Revathi, Venugopal, Anitha, Acharya, Nisha, Seitzman, Gerami, Rose-Nussbaumer, Jennifer, Woodward, Maria, Lietman, Thomas, Campbell, John, Keenan, Jeremy, and Redd, Travis
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Humans ,Corneal Ulcer ,Ulcer ,Reproducibility of Results ,Eye Infections ,Bacterial ,Bacteria ,Eye Infections ,Fungal ,India - Abstract
PURPOSE: This study sought to identify the sources of differential performance and misclassification error among local (Indian) and external (non-Indian) corneal specialists in identifying bacterial and fungal keratitis based on corneal photography. METHODS: This study is a secondary analysis of survey data assessing the ability of corneal specialists to identify acute bacterial versus fungal keratitis by using corneal photography. One-hundred images of 100 eyes from 100 patients with acute bacterial or fungal keratitis in South India were previously presented to an international cohort of cornea specialists for interpretation over the span of April to July 2021. Each expert provided a predicted probability that the ulcer was either bacterial or fungal. Using these data, we performed multivariable linear regression to identify factors predictive of expert performance, accounting for primary practice location and surrogate measures to infer local fungal ulcer prevalence, including locality, latitude, and dew point. In addition, Brier score decomposition was used to determine experts reliability (calibration) and resolution (boldness) and were compared between local (Indian) and external (non-Indian) experts. RESULTS: Sixty-six experts from 16 countries participated. Indian practice location was the only independently significant predictor of performance in multivariable linear regression. Resolution among Indian experts was significantly better (0.08) than among non-Indian experts (0.01; P < 0.001), indicating greater confidence in their predictions. There was no significant difference in reliability between the two groups ( P = 0.40). CONCLUSION: Local cornea experts outperformed their international counterparts independent of regional variability in tropical risk factors for fungal keratitis. This may be explained by regional characteristics of infectious ulcers with which local corneal specialists are familiar.
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- 2024
23. Scheduling Splittable Jobs on Configurable Machines
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Casey, Matthew, Rajaraman, Rajmohan, and Stalfa, David
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Computer Science - Data Structures and Algorithms - Abstract
Motivated by deep neural network applications, we study the problem of scheduling splittable jobs (e.g., neural network inference tasks) on configurable machines (e.g., multi-instance GPUs). We are given $n$ jobs and a set $C$ of configurations (e.g, representing ways to configure a GPU) consisting of multisets of blocks (e.g., representing GPU instances). A schedule consists of a set of machines, each assigned some configuration in $C$ with each block in the configuration assigned to process one job. The amount of a job's demand that is satisfied by a given block is an arbitrary function of the job and block. The objective is to satisfy all demands on as few machines as possible. We provide a tight logarithmic approximation algorithm for this problem in the general setting, an asymptotic $(2 + \varepsilon)$-approximation with $O(1)$ input configurations for arbitrary $\varepsilon > 0$, and a polynomial time approximation scheme when both the number and size of configurations are $O(1)$.
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- 2023
24. A Generic NLI approach for Classification of Sentiment Associated with Therapies
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Kanagasabai, Rajaraman and Veeramani, Anitha
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Computer Science - Computation and Language ,Computer Science - Artificial Intelligence - Abstract
This paper describes our system for addressing SMM4H 2023 Shared Task 2 on "Classification of sentiment associated with therapies (aspect-oriented)". In our work, we adopt an approach based on Natural language inference (NLI) to formulate this task as a sentence pair classification problem, and train transformer models to predict sentiment associated with a therapy on a given text. Our best model achieved 75.22\% F1-score which was 11\% (4\%) more than the mean (median) score of all teams' submissions., Comment: Accepted in Workshop on Social Media Mining for Health 2023 (#SMM4H)
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- 2023
25. Sample Complexity of Opinion Formation on Networks with Linear Regression Models
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Liu, Haolin, Rajaraman, Rajmohan, Sundaram, Ravi, Vullikanti, Anil, Wasim, Omer, and Xu, Haifeng
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Computer Science - Computer Science and Game Theory ,Computer Science - Machine Learning ,Computer Science - Social and Information Networks - Abstract
Consider public health officials aiming to spread awareness about a new vaccine in a community interconnected by a social network. How can they distribute information with minimal resources, so as to avoid polarization and ensure community-wide convergence of opinion? To tackle such challenges, we initiate the study of sample complexity of opinion convergence in networks. Our framework is built on the recognized opinion formation game, where we regard the opinion of each agent as a data-derived model, unlike previous works that treat opinions as data-independent scalars. The opinion model for every agent is initially learned from its local samples and evolves game-theoretically as all agents communicate with neighbors and revise their models towards an equilibrium. Our focus is on the sample complexity needed to ensure that the opinions converge to an equilibrium such that the final model of every agent has low generalization error. Our paper has two main technical results. First, we present a novel polynomial time optimization framework to quantify the total sample complexity for arbitrary networks, when the underlying learning problem is (generalized) linear regression. Second, we leverage this optimization to study the network gain which measures the improvement of sample complexity when learning over a network compared to that in isolation. Towards this end, we derive network gain bounds for various network classes including cliques, star graphs, and random regular graphs. Additionally, our framework provides a method to study sample distribution within the network, suggesting that it is sufficient to allocate samples inversely to the degree. Empirical results on both synthetic and real-world networks strongly support our theoretical findings.
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- 2023
26. On Q-balls in Anti de Sitter Space
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Rajaraman, Arvind, Stewart, Alexander, and Verhaaren, Christopher B.
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High Energy Physics - Theory ,High Energy Physics - Phenomenology - Abstract
We perform a general analysis of thin-wall Q-balls in AdS space. We provide numeric solutions and highly accurate analytic approximations over much of the parameter space. These analytic solutions show that AdS Q-balls exhibit significant differences from the corresponding flat space solitons. This includes having a maximum radius beyond which the Q-balls are unstable to a new type of state where the Q-ball coexists with a gas of massive particles. The phase transition to this novel state is found to be a zero-temperature third-order transition. This, through the AdS/CFT correspondence, has implications for a scalar condensate in the boundary theory., Comment: 21 pages, 10 figures. Updated to published version
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- 2023
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27. Uncovering the effects of model initialization on deep model generalization: A study with adult and pediatric Chest X-ray images
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Rajaraman, Sivaramakrishnan, Zamzmi, Ghada, Yang, Feng, Liang, Zhaohui, Xue, Zhiyun, and Antani, Sameer
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Model initialization techniques are vital for improving the performance and reliability of deep learning models in medical computer vision applications. While much literature exists on non-medical images, the impacts on medical images, particularly chest X-rays (CXRs) are less understood. Addressing this gap, our study explores three deep model initialization techniques: Cold-start, Warm-start, and Shrink and Perturb start, focusing on adult and pediatric populations. We specifically focus on scenarios with periodically arriving data for training, thereby embracing the real-world scenarios of ongoing data influx and the need for model updates. We evaluate these models for generalizability against external adult and pediatric CXR datasets. We also propose novel ensemble methods: F-score-weighted Sequential Least-Squares Quadratic Programming (F-SLSQP) and Attention-Guided Ensembles with Learnable Fuzzy Softmax to aggregate weight parameters from multiple models to capitalize on their collective knowledge and complementary representations. We perform statistical significance tests with 95% confidence intervals and p-values to analyze model performance. Our evaluations indicate models initialized with ImageNet-pre-trained weights demonstrate superior generalizability over randomly initialized counterparts, contradicting some findings for non-medical images. Notably, ImageNet-pretrained models exhibit consistent performance during internal and external testing across different training scenarios. Weight-level ensembles of these models show significantly higher recall (p<0.05) during testing compared to individual models. Thus, our study accentuates the benefits of ImageNet-pretrained weight initialization, especially when used with weight-level ensembles, for creating robust and generalizable deep learning solutions., Comment: 40 pages, 8 tables, 7 figures, 3 supplementary figures and 4 supplementary tables
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- 2023
28. Semantically Redundant Training Data Removal and Deep Model Classification Performance: A Study with Chest X-rays
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Rajaraman, Sivaramakrishnan, Zamzmi, Ghada, Yang, Feng, Liang, Zhaohui, Xue, Zhiyun, and Antani, Sameer
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Deep learning (DL) has demonstrated its innate capacity to independently learn hierarchical features from complex and multi-dimensional data. A common understanding is that its performance scales up with the amount of training data. Another data attribute is the inherent variety. It follows, therefore, that semantic redundancy, which is the presence of similar or repetitive information, would tend to lower performance and limit generalizability to unseen data. In medical imaging data, semantic redundancy can occur due to the presence of multiple images that have highly similar presentations for the disease of interest. Further, the common use of augmentation methods to generate variety in DL training may be limiting performance when applied to semantically redundant data. We propose an entropy-based sample scoring approach to identify and remove semantically redundant training data. We demonstrate using the publicly available NIH chest X-ray dataset that the model trained on the resulting informative subset of training data significantly outperforms the model trained on the full training set, during both internal (recall: 0.7164 vs 0.6597, p<0.05) and external testing (recall: 0.3185 vs 0.2589, p<0.05). Our findings emphasize the importance of information-oriented training sample selection as opposed to the conventional practice of using all available training data., Comment: 3 Tables, 11 Figures, 20 pages
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- 2023
29. Probing muon g-2 at a future muon collider
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Arakawa, Jason, Rajaraman, Arvind, Sui, Taotao, and Tait, Tim MP
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Nuclear and Plasma Physics ,Particle and High Energy Physics ,Physical Sciences ,Mathematical sciences ,Physical sciences - Abstract
The 4.2σ discrepancy in the (g − 2) of the muon provides a hint that may indicate that physics beyond the standard model is at play. A multi-TeV scale muon collider provides a natural testing ground for this physics. In this paper, we discuss the potential to probe the BSM parameter space that is consistent with solving the (g − 2)µ discrepancy in the language of the SMEFT, utilizing the statistical power provided by fitting event rates collected running at multiple energies. Our results indicate the importance of including interference between the BSM and the SM amplitudes, and illustrates how a muon collider running at a handful of lower energies and with less total collected luminosity can better significantly constrain the space of relevant SMEFT coefficients than would be possible for a single high energy run.
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- 2024
30. Aggregate morphing of self-aligning soft active disks in semi-confined geometry
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Anshika Chugh, Soumen De Karmakar, and Rajaraman Ganesh
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Medicine ,Science - Abstract
Abstract We study the dependence of alignment and confinement on the aggregate morphology of self-aligning soft disks(particles) in a planer box (two dimensional) geometry confined along y direction using Langevin dynamics simulations. We show that when the box width decreases, the aggregate wall accumulation becomes non-uniform and displays non-monotonic behaviour in terms of phase behavior and height of these aggregates with an increase in alignment strength. Additionally, we identify two distinct categories of wall aggregates: layered and non-layered structures each exhibiting distinct local structural properties. For non-layered structures, local speed of the particles stay nearly constant as we move away from the boundary, while for layered structures, it increases with distance from the boundary. Our analysis shows that active pressure difference is a useful indicator for different aggregate morphologies and the peaks in the pressure curve are indicative of the average and minimum height of the structure.
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- 2024
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31. The diagnostic performance of neck ultrasound in follow-up of advanced stage differentiated thyroid cancer
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Vicki Munro, Syed Mustafa, Ferhan S. Siddiqi, Murali Rajaraman, Andreu F. Costa, and Syed Ali Imran
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Thyroid cancer ,Ultrasound ,Thyroglobulin ,Prognosis ,Recurrence ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Abstract Background Differentiated thyroid cancer (DTC) requires long-term follow-up due to the risk of delayed recurrence. Follow-up surveillance involves serial neck ultrasound (US) and thyroglobulin (Tg); however, the optimal frequency and diagnostic performance of neck US outside of specialized thyroid cancer centres in higher risk patients is not well defined. We sought to evaluate the diagnostic performance of US and serial Tg in advanced stage DTC. Methods We retrospectively reviewed our thyroid cancer database for patients with stage III and IV DTC from 2006 to 2018, total thyroidectomy, and at least 2 years follow-up to assess recurrence rates. Those with hemi-thyroidectomy or anti-Tg antibodies were excluded. Diagnostic performance of US and Tg were assessed using a composite reference standard of follow-up imaging and pathology. All relevant US were reviewed by a blinded expert radiologist for uniformity. Results Of 136 included patients (91 females, mean age 58.9), 26 (19%) had recurrence of DTC over median follow-up of 6.6 years (IQR 5.3–9.3). The sensitivity and specificity of US in diagnosing cervical recurrence were 73.3% (95% CI 0.51–0.96) and 68.3% (95% CI 0.60–0.77) based on historical reports, respectively, and 80% (95% CI 0.60-1.00) and 87.8% (95% CI 0.82–0.93) based on blinded expert review, respectively. Tg had a sensitivity of 95.5% (95% CI 0.89-1.0) and specificity of 96.2% (95% CI 0.92–0.99) in detecting cervical recurrence or distant metastases. False positive US findings on historical US and subsequent review occurred in 38 (28%) and 15 (11%) patients, respectively, while 5 (3.6%) had false positive Tg results. Conclusion Serial Tg has better sensitivity and specificity than US for detecting recurrence of advanced stage DTC. Furthermore, re-interpretation of abnormal findings using structured US reporting with a subspecialized reader may improve diagnostic performance of US and improve its utility in clinical care.
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- 2024
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32. Association between in vitro susceptibility and clinical outcomes in fungal keratitis
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Louisa Lu, N. Venkatesh Prajna, Prajna Lalitha, Revathi Rajaraman, Muthiah Srinivasan, Benjamin F. Arnold, Nisha Acharya, Thomas Lietman, and Jennifer Rose-Nussbaumer
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Fungal keratitis ,Microbial susceptibility ,Antifungals ,Minimum inhibitory concentration ,Therapeutic penetrating keratoplasty ,Ophthalmology ,RE1-994 - Abstract
Abstract Purpose The purpose of this study was to assess the association between antifungal susceptibility as measured by minimum inhibitory concentration (MIC) and clinical outcomes in fungal keratitis. Methods This pre-specified secondary analysis of the Mycotic Ulcer Treatment Trial II (MUTT II) involved patients with filamentous fungal keratitis presenting to Aravind Eye Hospitals in South India. Antifungal susceptibility testing for natamycin and voriconazole was performed on all samples with positive fungal culture results according to Clinical and Laboratory Standards Institute Guidelines. The relationship between MIC and clinical outcomes of best-corrected visual acuity, infiltrate or scar size, corneal perforation, need for therapeutic penetrating keratoplasty, and time to re-epithelialization were assessed. Results We obtained MIC values from 141 patients with fungal keratitis. The most commonly cultured organisms were Aspergillus (46.81%, n = 66) and Fusarium (44.68%, n = 63) species. Overall, there was no association between antifungal MICs and clinical outcomes. Subgroup analysis revealed that among Fusarium-positive cases, higher voriconazole MIC was correlated with worse three-month best-corrected visual acuity (p = 0.03), increased need for therapeutic penetrating keratoplasty (p = 0.04), and time to re-epithelialization (p = 0.03). No significant correlations were found among Aspergillus-positive cases. There were no significant correlations found between natamycin MIC and clinical outcomes among organism subgroups. Conclusions Decreased susceptibility to voriconazole was associated with increased odds of requiring a therapeutic penetrating keratoplasty in Fusarium-positive cases. Susceptibility to natamycin was not associated with any of the measured outcomes.
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- 2024
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33. One Tree to Rule Them All: Poly-Logarithmic Universal Steiner Tree
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Busch, Costas, Chen, Da Qi, Filtser, Arnold, Hathcock, Daniel, Hershkowitz, D Ellis, and Rajaraman, Rajmohan
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Computer Science - Data Structures and Algorithms - Abstract
A spanning tree $T$ of graph $G$ is a $\rho$-approximate universal Steiner tree (UST) for root vertex $r$ if, for any subset of vertices $S$ containing $r$, the cost of the minimal subgraph of $T$ connecting $S$ is within a $\rho$ factor of the minimum cost tree connecting $S$ in $G$. Busch et al. (FOCS 2012) showed that every graph admits $2^{O(\sqrt{\log n})}$-approximate USTs by showing that USTs are equivalent to strong sparse partition hierarchies (up to poly-logs). Further, they posed poly-logarithmic USTs and strong sparse partition hierarchies as open questions. We settle these open questions by giving polynomial-time algorithms for computing both $O(\log ^ 7 n)$-approximate USTs and poly-logarithmic strong sparse partition hierarchies. For graphs with constant doubling dimension or constant pathwidth we improve this to $O(\log n)$-approximate USTs and $O(1)$ strong sparse partition hierarchies. Our doubling dimension result is tight up to second order terms. We reduce the existence of these objects to the previously studied cluster aggregation problem and what we call dangling nets., Comment: @FOCS23
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- 2023
34. The development, content and response process validation of a caregiver-reported severity measure for CDKL5 deficiency disorder.
- Author
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Ziniel, Sonja, Mackie, Alexandra, Saldaris, Jacinta, Leonard, Helen, Jacoby, Peter, Marsh, Eric, Suter, Bernhard, Pestana-Knight, Elia, Olson, Heather, Price, Dana, Weisenberg, Judith, Rajaraman, Rajsekar, VanderVeen, Gina, Benke, Tim, Downs, Jenny, and Demarest, Scott
- Subjects
CDKL5 deficiency disorder ,Caregiver-report ,Developmental attainment ,Outcome measure ,Severity ,Validation ,Child ,Humans ,Infant ,Child ,Preschool ,Adolescent ,Young Adult ,Adult ,Caregivers ,Spasms ,Infantile ,Epileptic Syndromes ,Surveys and Questionnaires ,Protein Serine-Threonine Kinases - Abstract
BACKGROUND: CDKL5 Deficiency Disorder (CDD) is a severe X-linked developmental and epileptic encephalopathy. Existing developmental outcome measures have floor effects and cannot capture incremental changes in symptoms. We modified the caregiver portion of a CDD clinical severity assessment (CCSA) and assessed content and response-process validity. METHODS: We conducted cognitive interviews with 15 parent caregivers of 1-39-year-old children with CDD. Caregivers discussed their understanding and concerns regarding appropriateness of both questions and answer options. Item wording and questionnaire structure were adjusted iteratively to ensure questions were understood as intended. RESULTS: The CCSA was refined during three rounds of cognitive interviews into two measures: (1) the CDD Developmental Questionnaire - Caregiver (CDQ-Caregiver) focused on developmental skills, and (2) the CDD Clinical Severity Assessment - Caregiver (CCSA-Caregiver) focused on symptom severity. Branching logic was used to ensure questions were age and skill appropriate. Initial pilot data (n = 11) suggested no floor effects. CONCLUSIONS: This study modified the caregiver portion of the initial CCSA and provided evidence for its content and response process validity.
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- 2023
35. The diagnostic performance of neck ultrasound in follow-up of advanced stage differentiated thyroid cancer
- Author
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Munro, Vicki, Mustafa, Syed, Siddiqi, Ferhan S., Rajaraman, Murali, Costa, Andreu F., and Imran, Syed Ali
- Published
- 2024
- Full Text
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36. Allopolyploid origin and diversification of the Hawaiian endemic mints
- Author
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Tomlin, Crystal M., Rajaraman, Sitaram, Sebesta, Jeanne Theresa, Scheen, Anne-Cathrine, Bendiksby, Mika, Low, Yee Wen, Salojärvi, Jarkko, Michael, Todd P., Albert, Victor A., and Lindqvist, Charlotte
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- 2024
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37. Bone marrow-derived mesenchymal stem cells mitigate chronic colitis and enteric neuropathy via anti-inflammatory and anti-oxidative mechanisms
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Stavely, Rhian, Robinson, Ainsley M., Fraser, Sarah, Filippone, Rhiannon T., Stojanovska, Vanesa, Eri, Rajaraman, Apostolopoulos, Vasso, Sakkal, Samy, and Nurgali, Kulmira
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- 2024
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38. Effect of flow shear on the onset of dynamos
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Biswas, Shishir and Ganesh, Rajaraman
- Subjects
Physics - Plasma Physics ,Astrophysics - Astrophysics of Galaxies ,Physics - Computational Physics ,Physics - Fluid Dynamics - Abstract
Understanding the origin and structure of mean magnetic fields in astrophysical conditions is a major challenge. Shear flows often coexist in such astrophysical conditions and the role of flow shear on dynamo mechanism is only beginning to be investigated. Here, we present a direct numerical simulation (DNS) study of the effect of flow shear on dynamo instability for a variety of base flows with controllable mirror symmetry (i.e, fluid helicity). Our observations suggest that for helical base flow, the effect of shear is to suppress the small scale dynamo (SSD) action, i.e, shear helps the large scale magnetic field to manifest itself by suppressing SSD action. For non-helical base flows, flow shear has the opposite effect of amplifying the small-scale dynamo action. The magnetic energy growth rate ($\gamma$) for non-helical base flows are found to follow an algebraic nature of the form, $\gamma = - aS + bS^\frac{2}{3}$ , where a, b > 0 are real constants and S is the shear flow strength and $\gamma$ is found to be independent of scale of flow shear. Studies with different shear profiles and shear scale lengths for non-helical base flows have been performed to test the universality of our finding.
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- 2023
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39. Greedy Pruning with Group Lasso Provably Generalizes for Matrix Sensing
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Rajaraman, Nived, Devvrit, Mokhtari, Aryan, and Ramchandran, Kannan
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Computer Science - Machine Learning ,Statistics - Machine Learning - Abstract
Pruning schemes have been widely used in practice to reduce the complexity of trained models with a massive number of parameters. In fact, several practical studies have shown that if a pruned model is fine-tuned with some gradient-based updates it generalizes well to new samples. Although the above pipeline, which we refer to as pruning + fine-tuning, has been extremely successful in lowering the complexity of trained models, there is very little known about the theory behind this success. In this paper, we address this issue by investigating the pruning + fine-tuning framework on the overparameterized matrix sensing problem with the ground truth $U_\star \in \mathbb{R}^{d \times r}$ and the overparameterized model $U \in \mathbb{R}^{d \times k}$ with $k \gg r$. We study the approximate local minima of the mean square error, augmented with a smooth version of a group Lasso regularizer, $\sum_{i=1}^k \| U e_i \|_2$. In particular, we provably show that pruning all the columns below a certain explicit $\ell_2$-norm threshold results in a solution $U_{\text{prune}}$ which has the minimum number of columns $r$, yet close to the ground truth in training loss. Moreover, in the subsequent fine-tuning phase, gradient descent initialized at $U_{\text{prune}}$ converges at a linear rate to its limit. While our analysis provides insights into the role of regularization in pruning, we also show that running gradient descent in the absence of regularization results in models which {are not suitable for greedy pruning}, i.e., many columns could have their $\ell_2$ norm comparable to that of the maximum. To the best of our knowledge, our results provide the first rigorous insights on why greedy pruning + fine-tuning leads to smaller models which also generalize well., Comment: 49 pages, 2 figures
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- 2023
40. Undifferentiated Embryonal Sarcoma of Liver- A Rare Case Entity
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Gayathri B Rajaraman, K Chandramouleeswari, M Dougul Regis, and J Nivedita
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hepatic hydatid cyst ,malignant mesenchymal neoplasm ,tumour cell cytoplasm ,Microbiology ,QR1-502 ,Chemistry ,QD1-999 - Abstract
Undifferentiated Embryonal Sarcoma of the Liver (UESL) is a rare hepatic malignant mesenchymal neoplasm in the paediatric population, typically affecting children between 6-10 years of age without sex predilection. It accounts for 9-15% of paediatric liver malignancies, with an incidence of 0.6-1.2 cases per one million patients. Here, the authors present a case of an 11-year-old male, who presented with right upper quadrant pain, loss of appetite for the past one month, and high-grade fever for the past three days. On examination, a firm mass in the right hypochondrium and epigastrium, about 4 cm below the right costal margin, was noted, moving with respiration. Blood work showed normal values and normal alpha-fetoprotein levels. An ultrasonogram revealed a cystic lesion, while a contrast-enhanced Computed Tomography (CT) scan showed a large hepatic space-occupying lesion with cystic and solid architecture, with the following differential diagnosis as, embryonal sarcoma and hepatoblastoma. The patient underwent surgery for a hepatic hydatid cyst, and the procedure performed was percutaneous aspiration, irrigation and respiration. Gross examination revealed multiple grey-brown and grey-white fragments with a variegated appearance. Microscopic analysis showed a malignant neoplasm composed of spindle cells, stellate cells, multinucleated giant cells in a myxoid stroma, with many atypical mitoses present. Periodic Acid-Schiff (PAS) positive eosinophilic hyaline globules were observed in the tumour cell cytoplasm, along with extensive areas of haemorrhage and necrosis. The final diagnosis of embryonal sarcoma was made after a panel of Immunohistochemistry (IHC) markers. The present case is presented here due to its rarity and diagnostic challenge, arising from the lack of a characteristic clinical presentation, serological markers and inconclusive radiological findings.
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- 2024
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41. A theoretical approach on ADMET properties of an azo-ester based fluorophore (AEF), and it's energetics, binding stability and molecular interactions with select globular proteins
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Arumugam Gopalakrishnan, Ravichandran Keerthiga, Murugan Sreedevi Sangeetha, Seba Merin Vinod, Perumal Tamizhdurai, V.L. Mangesh, Rajaraman Vasanthi, Vaidyanathan Rajagopalan, Rajendran Kumaran, and Mahalingam Vanjinathan
- Subjects
Azo ester ,Serum albumins ,Hydrogen-bonding ,Hydrophobic interactions ,Molecular docking ,Binding energy ,Chemical engineering ,TP155-156 - Abstract
Molecular docking (Mol.Doc) approach of an azo-ester based fluorophore (AEF) with widely studied proteins like Human serum Albumin (HSA), Bovine serum Albumin (BSA), Beta lactoglobin (βLG) and Ovalbumin (OVA) were carried out. The binding affinity and strength of AEF-HSA complex is due to hydrogen-bonding (h-bonding) and hydrophobic interactions (predominantly attributed to pi-alkyl). AEF and HSA acts as h-bonding acceptor as well as donor. The energetically favored conformers of AEF-HSA complex are governed and stabilized by polar as well as non-polar amino acids. On the contrary, the pattern observed in all the conformers of AEF-BSA, AEF- βLG and AEF-OVA are energetically least favored (+ve ∆G) compared to that of HSA. The least binding affinity of AEF is towards OVA (Binding energy (BE) +581.15 Kcalmol−1 followed by βLG (+55.11) and BSA (+12.12) . Though BSA and HSA are structurally similar to each other, they vary in the binding stability with AEF. This is attributed to several unfavorable interactions that destabilize AEF-BSA complex which was not resulted in the complex existing between AEF-HSA. The energetically least stable complexes (AEF-BSA, AEF-βLG and AEF-OVA) are predominantly governed by hydrophobic interactions. However, several h-bonding interactions along with pi-sigma/pi-pi/pi-alkyl interactions result in destabilization of the above complexes. Interestingly, AEF-HSA complex stability is attributed to fewer number of hydrophobic interactions along with h-bonding interactions. The h-bonding interaction governs the stability of the complex which is the driving force. Docking studies illustrates that the binding of amino acids (AAs) in various subdomains play a significant role on the binding nature. The stability of AEF-HSA over other protein complexes in terms of BE is emphasized in the study. The energetically stable sites and sub-domains of AEF with HSA and BSA establish the site selective and site-specific nature of AEF with proteins. In silico studies provide an excellent and easier approach in establishing the molecular interactions existing between AEF with globular proteins. ADMET parameters of the guest molecule calculated exemplifies that AEF compound is less toxic and possesses high oral bioavailability. Based on the binding efficiency of AEF with albumins, the ADMET properties and drug likeliness approach of AEF provides an information on the application towards proteins in the concept of medicine and chemistry.
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- 2024
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42. Epileptic spasms relapse is associated with response latency but not conventional attributes of post‐treatment EEG
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Emmi Deckard, Rujuta Sathe, David Tabibzadeh, Aria Terango, Aran Groves, Rajsekar R. Rajaraman, Hiroki Nariai, and Shaun A. Hussain
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epileptiform discharges ,infantile spasms ,vigabatrin ,west syndrome ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Objective Relapse of epileptic spasms after initial treatment of infantile epileptic spasms syndrome (IESS) is common. However, past studies of small cohorts have inconsistently linked relapse risk to etiology, treatment modality, and EEG features upon response. Using a large single‐center IESS cohort, we set out to quantify the risk of epileptic spasms relapse and identify specific risk factors. Methods We identified all children with epileptic spasms at our center using a clinical EEG database. Using the electronic medical record, we confirmed IESS syndrome classification and ascertained treatment, response, time to relapse, etiology, EEG features, and other demographic factors. Relapse‐free survival analysis was carried out using Cox proportional hazards regression. Results Among 599 children with IESS, 197 specifically responded to hormonal therapy and/or vigabatrin (as opposed to surgery or other second‐line treatments). In this study, 41 (21%) subjects exhibited relapse of epileptic spasms within 12 months of response. Longer duration of IESS prior to response (>3 months) was strongly associated with shorter latency to relapse (hazard ratio = 3.11; 95% CI 1.59–6.10; p = 0.001). Relapse was not associated with etiology, developmental status, or any post‐treatment EEG feature. Significance This study suggests that long duration of IESS before response is the single largest clinical predictor of relapse risk, and therefore underscores the importance of prompt and successful initial treatment. Further study is needed to evaluate candidate biomarkers of epileptic spasms relapse and identify treatments to mitigate this risk. Plain Language Summary Relapse of infantile spasms is common after initially successful treatment. With study of a large group of children with infantile spasms, we determined that relapse is linked to long duration of infantile spasms. In contrast, relapse was not associated with the cause of infantile spasms, developmental measures, or EEG features at the time of initial response. Further study is needed to identify tools to predict impending relapse of infantile spasms.
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- 2024
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43. Slowly rotating Q-balls
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Almumin, Yahya, Heeck, Julian, Rajaraman, Arvind, and Verhaaren, Christopher B.
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High Energy Physics - Theory ,High Energy Physics - Phenomenology - Abstract
Q-balls are non-topological solitons arising in scalar field theories. Solutions for rotating Q-balls (and the related boson stars) have been shown to exist when the angular momentum is equal to an integer multiple of the Q-ball charge $Q$. Here we consider the possibility of classically long-lived metastable rotating Q-balls with small angular momentum, even for large charge, for all scalar theories that support non-rotating Q-balls. This is relevant for rotating extensions of Q-balls and related solitons such as boson stars as it impacts their cosmological phenomenology., Comment: 17 pages; major revision, matches EPJC version
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- 2023
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44. Statistical Complexity and Optimal Algorithms for Non-linear Ridge Bandits
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Rajaraman, Nived, Han, Yanjun, Jiao, Jiantao, and Ramchandran, Kannan
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Statistics - Machine Learning ,Computer Science - Information Theory ,Computer Science - Machine Learning ,Mathematics - Statistics Theory - Abstract
We consider the sequential decision-making problem where the mean outcome is a non-linear function of the chosen action. Compared with the linear model, two curious phenomena arise in non-linear models: first, in addition to the "learning phase" with a standard parametric rate for estimation or regret, there is an "burn-in period" with a fixed cost determined by the non-linear function; second, achieving the smallest burn-in cost requires new exploration algorithms. For a special family of non-linear functions named ridge functions in the literature, we derive upper and lower bounds on the optimal burn-in cost, and in addition, on the entire learning trajectory during the burn-in period via differential equations. In particular, a two-stage algorithm that first finds a good initial action and then treats the problem as locally linear is statistically optimal. In contrast, several classical algorithms, such as UCB and algorithms relying on regression oracles, are provably suboptimal., Comment: Revised Section 3 and added an upper bound agnostic to the link function $f$
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- 2023
45. Sample Efficient Deep Reinforcement Learning via Local Planning
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Yin, Dong, Thiagarajan, Sridhar, Lazic, Nevena, Rajaraman, Nived, Hao, Botao, and Szepesvari, Csaba
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence - Abstract
The focus of this work is sample-efficient deep reinforcement learning (RL) with a simulator. One useful property of simulators is that it is typically easy to reset the environment to a previously observed state. We propose an algorithmic framework, named uncertainty-first local planning (UFLP), that takes advantage of this property. Concretely, in each data collection iteration, with some probability, our meta-algorithm resets the environment to an observed state which has high uncertainty, instead of sampling according to the initial-state distribution. The agent-environment interaction then proceeds as in the standard online RL setting. We demonstrate that this simple procedure can dramatically improve the sample cost of several baseline RL algorithms on difficult exploration tasks. Notably, with our framework, we can achieve super-human performance on the notoriously hard Atari game, Montezuma's Revenge, with a simple (distributional) double DQN. Our work can be seen as an efficient approximate implementation of an existing algorithm with theoretical guarantees, which offers an interpretation of the positive empirical results., Comment: 25 pages, 11 figures
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- 2023
46. Does image resolution impact chest X-ray based fine-grained Tuberculosis-consistent lesion segmentation?
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Rajaraman, Sivaramakrishnan, Yang, Feng, Zamzmi, Ghada, Xue, Zhiyun, and Antani, Sameer
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Electrical Engineering and Systems Science - Image and Video Processing ,Computer Science - Computer Vision and Pattern Recognition - Abstract
Deep learning (DL) models are state-of-the-art in segmenting anatomical and disease regions of interest (ROIs) in medical images. Particularly, a large number of DL-based techniques have been reported using chest X-rays (CXRs). However, these models are reportedly trained on reduced image resolutions for reasons related to the lack of computational resources. Literature is sparse in discussing the optimal image resolution to train these models for segmenting the Tuberculosis (TB)-consistent lesions in CXRs. In this study, we investigated the performance variations using an Inception-V3 UNet model using various image resolutions with/without lung ROI cropping and aspect ratio adjustments, and (ii) identified the optimal image resolution through extensive empirical evaluations to improve TB-consistent lesion segmentation performance. We used the Shenzhen CXR dataset for the study which includes 326 normal patients and 336 TB patients. We proposed a combinatorial approach consisting of storing model snapshots, optimizing segmentation threshold and test-time augmentation (TTA), and averaging the snapshot predictions, to further improve performance with the optimal resolution. Our experimental results demonstrate that higher image resolutions are not always necessary, however, identifying the optimal image resolution is critical to achieving superior performance., Comment: 17 pages, 7 figures, 5 tables
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- 2023
47. Multidisciplinary Canadian consensus on the multimodal management of high-risk and radioactive iodine-refractory thyroid carcinoma
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Shereen Ezzat, Jesse D. Pasternak, Murali Rajaraman, Omar Abdel-Rahman, Andrée Boucher, Nicole G. Chau, Shirley Chen, Sabrina Gill, Martin D. Hyrcza, Nathan Lamond, Marie-Hélène Massicotte, Eric Winquist, and Ozgur Mete
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thyroid cancer ,targeted therapy ,molecular diagnosis ,radioiodine-refractory differentiated thyroid cancer ,multidisciplinary ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Most follicular cell-derived differentiated thyroid carcinomas are regarded as low-risk neoplasms prompting conservative therapeutic management. Here, we provide consensus recommendations reached by a multidisciplinary group of endocrinologists, medical oncologists, pathologists, radiation oncology specialists, a surgeon and a medication reimbursement specialist, addressing more challenging forms of this malignancy, focused on radioactive iodine (RAI)-resistant or -refractory differentiated thyroid carcinoma (RAIRTC). In this document we highlight clinical, radiographic, and molecular features providing the basis for these management plans. We distinguish differentiated thyroid cancers associated with more aggressive behavior from thyroid cancers manifesting as poorly differentiated and/or anaplastic carcinomas. Treatment algorithms based on risk-benefit assessments of different multimodal therapy approaches are also discussed. Given the scarcity of data supporting management of this rare yet aggressive disease entity, these consensus recommendations provide much needed guidance for multidisciplinary teams to optimally manage RAIRTC.
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- 2024
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48. Experiences & Perspectives on Injectable Contraceptive on Its Users in Tamil Nadu- A Qualitative Report
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Rajalakshmi Rajaraman, Sasi Vaithilingan, Rajeswari C, Selvavinayagam Thirumalaichiry Sivaprakasan, and Somasundaram Anavarathan
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Depot Medroxy Progesterone Acetate (DMPA) ,Injectable contraception ,Contraceptive method ,Perspectives towards DMPA ,Reproductive age women ,Public aspects of medicine ,RA1-1270 - Abstract
Background: Injectable contraception, Depot Medroxy-Progesterone Acetate (DMPA), is a popular birth control option due to its safety, effectiveness, and discretion. It offers three months protection with minimal impact on the daily lives, reducing the need for frequent visits to healthcare facilities. Understanding women’s experiences with DMPA is crucial for improving the quality of contraceptive services and their reproductive health outcomes. This study aimed to elucidate the experiences and perspectives of women using injectable contraceptive - Depot Medroxy-Progesterone Acetate. Methodology: The study employed a Phenomenological approach, with in-depth, semi-structured interviews among ten women, aged 21-40 years, who received DMPA at a Family Planning Clinic in Tamil Nadu, India. Participants who had used DMPA for at least three months to one year were selected using convenience sampling. Data were analysed and identified themes through the Colaizzi method. Results: Thematic analysis revealed eight key themes: reasons for choosing DMPA, decision-making process, concerns and discontinuation, information sources, management strategies, willingness to recommend, reluctance to recommend, and suggestions for improving DMPA utilization. Conclusions: This study highlights the need for enhancements in injectable contraceptive services, providing insights to inform future family planning policies and strategies.
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- 2024
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49. Methane emission, nitrogen excretion, and energy partitioning in Hanwoo steers fed a typical TMR diet supplemented with Pharbitis nil seeds
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Rajaraman Bharanidharan, Panyavong Xaysana, Woo Hyeong Hong, Taehoon Kim, Jun Suk Byun, Yookyung Lee, Byamungu Mayange Tomple, Kyoung Hoon Kim, and Ridha Ibidhi
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energy partitioning ,Hanwoo ,methane ,nitrogen utilization ,Pharbitis nil ,Veterinary medicine ,SF600-1100 - Abstract
Two in vivo experiments were conducted to evaluate the potential of Pharbitis nil seeds (PA) as an anti-methanogenic additive to ruminant feed. In experiment 1, six Hanwoo steers (459.0 ± 25.8 kg) were fed either a total mixed ration (TMR; 32-d period) or TMR supplemented with PA at 5% dry matter (DM) intake (TMR-PA; 45-d period) for two consecutive periods. Fecal and urine outputs were measured in an apparent digestibility trial in both periods. Methane (CH4) yield and heat energy (HE) were measured using respiratory chambers equipped with gas analyzers. In experiment 2, five rumen cannulated Holstein steers (744 ± 35 kg) were fed the same TMR or TMR-PA diets for 40 days; rumen samples were collected at 0, 1.5, and 3 h after feeding on the last day of the feeding period. In experiment 1, although there were no differences (p > 0.05) in nutrients or gross energy intake (GEI) between the groups, an increase (p < 0.05) in the apparent digestibility of DM (9.1%) and neutral detergent fiber (22.9%) was observed in the TMR-PA fed Hanwoo steers. Pronounced decreases (p < 0.05) in CH4 (g/Kg DM; 17.1%) and urinary N excretion (% N intake; 7.6%) were observed in the TMR-PA group, leading to a 14.7% increase in metabolizable energy intake (% GEI). However, only a numerical increase (p > 0.05) in retained energy was observed due to the increase in HE loss. In experiment 2, a drastic decrease (p < 0.05) in rumen ammonia concentration (56.3%) associated with an increased (p = 0.091) rumen short-chain fatty acid concentration 1.5 h after feeding were observed in TMR-PA fed Holstein steers. A 26.6% increase (p < 0.05) in the propionate proportion during the treatment period clearly reflected a shift in the ruminal H2 sink after 3 h of feeding. A 40% reduction (p = 0.067) in the relative abundance of rumen protozoa Entodinium caudatum was also observed. It was concluded that PA could be a natural feed additive for CH4 and N emission abatement.
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- 2024
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50. Effect of sodium formate and lactic acid bacteria treated rye silage on methane yield and energy balance in Hanwoo steers
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Yongjun Choi, Jayeon Kim, Geumhwi Bang, Nayeon Kim, Krishnaraj Thirugnanasambantham, Sangrak Lee, Kyoung Hoon Kim, and Rajaraman Bharanidharan
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Lactic acid inoculant ,Sodium formate ,Acid-based additives ,Silage ,Methane production ,Hanwoo. ,Medicine ,Biology (General) ,QH301-705.5 - Abstract
This study was performed to evaluate the effects of rye silage treated with sodium formate (Na-Fa) and lactic acid bacteria (LAB) inoculants on the ruminal fermentation characteristics, methane yield and energy balance in Hanwoo steers. Forage rye was harvested in May 2019 and ensiled without additives (control) or with either a LAB inoculant or Na-Fa. The LAB (Lactobacillus plantarum) were inoculated at 1.5 × 1010 CFU/g fresh matter, and the inoculant was sprayed onto the forage rye during wrapping at a rate of 4 L/ton of fresh rye forage. Sixteen percent of the Na-Fa solution was sprayed at a rate of approximately 6.6 L/ton. Hanwoo steers (body weight 275 ± 8.4 kg (n = 3, group 1); average body weight 360 ± 32.1 kg (n = 3, group 2)) were allocated into two pens equipped with individual feeding gates and used in duplicated 3 × 3 Latin square design. The experimental diet was fed twice daily (09:00 and 18:00) during the experimental period. Each period comprised 10 days for adaptation to the pen and 9 days for measurements in a direct respiratory chamber. The body weights of the steers were measured at the beginning and at the end of the experiment. Feces and urine were collected for 5 days after 1 day of adaptation to the chamber, methane production was measured for 2 days, and ruminal fluid was collected on the final day. In the LAB group, the ratio of acetic acid in the rumen fluid was significantly lower (p = 0.044) and the ratio of propionic acid in the rumen fluid was significantly higher (p = 0.017). Methane production per DDMI of the Na-FA treatment group was lower than that of the other groups (p = 0.052), and methane production per DNDFI of the LAB treatment group was higher than that of the other groups (p = 0.056). The use of an acid-based additive in silage production has a positive effect on net energy and has the potential to reduce enteric methane emissions in ruminants.
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- 2024
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