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2 results on '"Raherisson, C."'

1. Immune checkpoint inhibitors versus second line chemotherapy for patients with lung cancer refractory to first line chemotherapy

Author

Lefebvre, C., Lefebvre, C., Martin, E., Hendriks, L. E. L., Veillon, R., Puisset, F., Mezquita, L., Ferrara, R., Sabatier, M., Filleron, T., Dingemans, A-M C., Besse, B., Raherisson, C., Mazieres, J., Lefebvre, C., Lefebvre, C., Martin, E., Hendriks, L. E. L., Veillon, R., Puisset, F., Mezquita, L., Ferrara, R., Sabatier, M., Filleron, T., Dingemans, A-M C., Besse, B., Raherisson, C., and Mazieres, J.

Abstract

Purpose. - Anti Programmed Death-ligand (PD1/PD-L1) directed immune-checkpoint-inhibitors (ICI) are widely used to treat patients with advanced non-small cell lung cancer (NSCLC) who progress after first line chemotherapy. The best strategy after early progression under first line has not been specifically studied.Patients and methods. - We conducted a multicenter, retrospective study including all consecutive NSCLC patients progressing within the first 3 months following introduction of first-line chemotherapy and being treated with second line ICI monotherapy or chemotherapy between March 2010 and November 2017. We analysed the clinicopathological data and outcome under second line chemotherapy vs. second line ICI: objective response rate (ORR), progression-free survival (PFS), overall survival (OS.Results. - We identified 176 patients with refractory disease, 99 who received subsequent immunotherapy and 77 undergoing chemotherapy. The 2 populations were comparable regarding the main prognostic criteria, median age was 60, main histology was adenocarcimoma (68.2%). PFS was not significantly different between both treatments 1.9 [1.8-2.1] versus 1.6 month [1.4-2.0] (P = 0.125). Compared to chemotherapy, ICI treated patients had a superior OS (P= 0.03) (Median [95% CI] OS 4.6 [2.8-6.7] versus 4.2 months [3.4-5.9] and a non-significant improvement in ORR (17.2% versus 7.9%, respectively, P = 0.072). Poor performance status (ECOG PS >= 2) and a higher number of metastatic sites (>= 3) were associated with poorer prognosis. KRAS-mutated patients did not seem to benefit more from ICI than chemotherapy.Conclusions. - ICI appears to be the preferred second-line treatment for patients who are refractory to first line chemotherapy.

Published
2020

2. Factors related to under-diagnosis and under-treatment of childhood asthma in metropolitan France.

Author

Annesi-Maesano I, Sterlin C, Caillaud D, de Blay F, Lavaud F, Charpin D, and Raherisson C

Abstract

Background: Under-diagnosis and under-treatment of childhood asthma were investigated in France using data collected during the 6 Cities Study, the French contribution to the International Study of Asthma and Allergies in Childhood., Methods: 7,781 schoolchildren aged between 9 and 10 years underwent a medical visit including skin prick tests to common allergens and exercise test for Exercise-Induced Asthma (EIA) and their parents filled in a standardized questionnaire on asthma, management, treatment and potential risk factors., Results: 903 children reported asthma (11.6%), 377 without a doctor's diagnosis. Of the 526 participants with a diagnosis of asthma confirmed by a doctor (58.2%), 353 were treated and 76 were not treated during the year preceding the investigation despite their diagnosis. The information on the treatment was missing for the rest of individuals diagnosed with asthma (n = 97). Having a treatment was significantly associated with severe asthma and with the presence of other respiratory and allergic stigmata (atopic eczema, rhinitis, positive skin allergy tests, and EIA). In addition, having a treatment did not correspond to a good control of the disease. Similarly, children with asthma-like symptoms but without doctor-diagnosed asthma had asthma less well controlled than children with diagnosed asthma. They were also more exposed to passive smoking and traffic but had fewer pets. In contrast, diagnosed children reported more frequently a small weight at birth and a preterm birth., Conclusions: In France, childhood asthma is still under-diagnosed and under-treated and environmental factors play a role in these phenomena.

Published
2012
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