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This study aims to evaluate whether there is a correlation and unidirectional or bidirectional causality between terrorist incidents and foreign direct investment in Türkiye. Toda Yamamoto elucidates that there is no long-term relationship. RLS, on the other hand, reveals that there is a short-term relationship, and that produces a more fascinating result. While foreign direct investment does not increase terrorist incidents, terrorist incidents possess a positive effect on foreign direct investment. In this case, terrorist actions increase foreign direct investment to Türkiye in the short term. It also appears that terrorist incidents concentrated in big cities do not possess a deterrent effect on foreign direct investments concentrated in big cities. [ABSTRACT FROM AUTHOR]

To solve the problem that the poor accuracy of long-term prediction relying on model accuracy for the filter-based prediction method, a fusion fault prediction algorithm based on filter and long short-term memory (LSTM) network is proposed to achieve the prediction of spacecraft flywheel slowly growing faults. Firstly, a mini-batch normalization LSTM network and a trend recognition module are designed, which are connected in series to form a neural network predictor to improve the time series prediction accuracy. Then, the Kalman filter update process is improved by the recursive least square (RLS) parameter estimation principle to enhance the robustness for time series prediction error. On this basis, the predicted values output by the neural network predictor are fused with the improved filter. Prediction residual can be obtained for iterative updating and prediction, overcoming the dependence of the filter algorithm on the model and improving prediction accuracy. Finally, the time series predictive performance of three neural network predictors are analyzed by simulation experiments. And considering the degradation fault of flywheel bearing performance, the proposed fusion prediction algorithm is used to determine that the flywheel degrades to a threshold at 856 s, with a prediction time error of 36 s. The simulation results verify the effectiveness of the proposed algorithm for slowly growing fault.

Copyright of Aero Weaponry is the property of Aero Weaponry Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: Epidemiological evidence indicates a high correlation and comorbidity between Attention Deficit Hyperactivity Disorder (ADHD) and Restless Legs Syndrome (RLS). Objective: We aimed to investigate the causal relationship and shared genetic architecture between ADHD and RLS, as well as explore potential causal associations between both disorders and peripheral iron status. Methods: We performed two-sampleMendelian randomization (MR) analyses using summary statistics from genome-widemeta-analyses of ADHD, RLS, and peripheral iron status (serumiron, ferritin, transferrin saturation, and total iron binding capacity). Additionally, we employed linkage disequilibrium score regression (LDSC) to assess genetic correlations between ADHD and RLS using genetic data. Results: Our MR results supports a causal effect from ADHD (as exposure) to RLS (as outcome) (inverse variance weighted OR = 1.20, 95% CI: 1.08-1.34, p = 0.001). Conversely, we found no a causal association from RLS to ADHD (inverse variance weighted OR = 1.04, 95% CI: 0.99-1.09, p = 0.11). LDSC analysis did not detect a significant genetic correlation between RLS and ADHD (Rg = 0.3, SE = 0.16, p = 0.068). Furthermore, no evidence supported a causal relationship between peripheral iron deficiency and the RLS or ADHD onset. However, RLS may have been associated with a genetic predisposition to reduced serum ferritin levels (OR = 1.20, 95% CI: 1.00-1.04, p = 0.047). Conclusion: This study suggests that ADHD is an independent risk factor for RLS, while RLS may confer a genetic predisposition to reduced serum ferritin levels. Limitations: The GWAS summary data utilized originated from populations of European ancestry, limiting the generalizability of conclusions to other populations. Clinical implications: The potential co-occurrence of RLS in individuals with ADHD should be considered during diagnosis and treatment. Moreover, iron supplementation may be beneficial for alleviating RLS symptoms. [ABSTRACT FROM AUTHOR]

Restless legs syndrome (RLS), also called Willis–Ekbom disease (WED), affects approximately 3% of the global population, with higher incidence in Caucasians and women. This review explores the latest advancements in the diagnosis, pathophysiology, and management of RLS, and it highlights the recent changes in diagnostic criteria that improve specificity. The diagnostic spectrum now includes atypical presentations involving the upper limbs and other body parts. The new diagnostic specifiers categorize RLS more effectively into chronic-persistent or intermittent types, and a clinical significance specifier has been introduced to better address the disorder's effects on daily life. RLS management has shifted toward a balanced approach with non-pharmacological strategies and lifestyle changes, supported by updated pharmacological treatment protocols including iron therapy designed to mitigate risks such as augmentation. Notably, gabapentinoids have emerged as a superior treatment option over dopamine agonists owing to their lower risk of augmentation and superior safety profile. Innovative treatments, such as the FDA-approved tonic motor activation device and new pharmacological agents, serve as alternatives for treating medication-refractory RLS, thereby expanding the therapeutic landscape. Additionally, this review addresses the specific considerations for managing RLS in special groups, including pregnant women, individuals with chronic kidney disease, and patients with comorbid conditions such as Parkinson's disease and multiple sclerosis. We emphasizes the dynamic nature of RLS research and highlight the critical need for ongoing studies to further elucidate the complex mechanisms underlying RLS, as well as to refine the treatment modalities to enhance patient outcomes. [ABSTRACT FROM AUTHOR]

Background: The coronavirus disease 2019 (COVID-19) is critically affecting not only the physical health but also mental health globally. This study aimed to define the frequency of sleep disorders in COVID-19 positive patients in Aswan University Hospitals, Aswan Governorate, Egypt to clarify the different clinical types of them and to identify factors associated with sleep changes during the COVID-19. Methods: Our study recruited 280 positive COVID-19 patients. Their sleep disorders were diagnosed by using Global Sleep Assessment questionnaire (GSAQ). Their socioeconomic status was determined by using Revised Kuppuswamy Socioeconomic Status Scale (RK SSS). The severity of anxiety symptoms and insomnia were determined by using Hamilton Anxiety Rating Scale (HARS) and Insomnia Severity Index (ISI) respectively. Diagnosis of Restless Leg Syndrome (RLS) was completed according to Restless Leg Syndrome Diagnostic Index (RLS-DI). Results: Sleep disorders were documented in 35.7% of our patients. They were categorized into insomnia (24.6%), RLS (15%) and poor sleep quality (17.4%). Younger age and female sex were the predominate age and sex. Most of them had severe anxiety. Upper class of socioeconomic status was the commonest SES. Most of patients had CORADS I and II respectively. Conclusion: The present study recognized that female gender, younger population, COVID- 19 related stressors were the major factors associated with sleep disorder. Further investigation is needed to understand the changes in sleep pattern among the patients of the COVID-19 pandemic.

【Objective】Optical fiber dispersion, nonlinear impairments, and bandwidth limitation in high-speed passive optical access networks result in significant power budget loss with traditional intensity modulation and direct detection schemes, failing to meet the requirements of high-speed passive optical access networks.【Methods】In order to enhance the rate and performance of the intensity modulation and direct detection optical access system, this study explores the channel equalization method of VDFE-RLS based on Recursive Least Squares (RLS) algorithm, building upon the Volterra Decision Feedback Equalizer (VDFE), This equalizer uses RLS algorithm to update its tap coefficients. It includes a three-order Volterra series, allowing it to compensate for both linear and nonlinear impairments. VDFE-RLS is applied to the downlink optical access system with a single wavelength of 200 Gbit/s based on O-band intensity modulation and direct detection scheme after 20 km transmission.【Results】The experimental results show that the RLS outperforms the conventional Least Mean Square (LMS) algorithm in the equalization process. Moreover, VDFE-RLS achieves a power budget greater than 29 dB. When the length of the equalizer is the same, VDFE-RLS can increase the power budget by 2.2 dB compared with the conventional Volterra Feed Forward Equalization (VFFE)-RLS equalizer. When the length of VDFE-RLS equalizer is half that of VFFE-RLS, the VDFE-RLS can increase the power budget by 0.5 dB compared with the VFFE-RLS equalizer.【Conclusion】Compared with other traditional methods, the proposed method can shorten the length of the equalizer and increase the power budget of the system, ultimately restoring signals with better performance.

Major depressive disorder (MDD) and Restless legs syndrome (RLS) present complex clinical challenges, often coexisting and complicating treatment strategies. While the relationship between MDD and RLS remains somewhat elusive, emerging evidence suggests a potential interplay between antidepressant medications and the worsening of RLS symptoms. This case report illuminates an instance where mirtazapine, a tetracyclic antidepressant commonly used in MDD, precipitated a resurgence of RLS symptoms in a patient with a previously controlled presentation. [ABSTRACT FROM AUTHOR]

In the present study, to address the issue of flow rate instability in the flow boiling experimental system, a flow rate adaptive control system is developed using a single-neuron PID adaptive algorithm, enhanced with the whale optimization algorithm (WOA) for parameter tuning. A recursive least-squares online identification method is integrated to adapt to varying operating conditions. The simulation results demonstrate that in step response the WOA-improved single-neuron PID significantly mitigates the overshoot, with a mere 0.31% overshoot observed, marking a reduction of 98.27% compared to the traditional PID control. The output curve of the WOA-improved single-neuron PID closely aligns with the sinusoidal signal, exhibiting an average absolute error of 0.120, which is lower than that of the traditional PID (0.209) and fuzzy PID (0.296). The WOA-improved single-neuron PID (1.01 s) exhibited a faster return to a stable state compared to the traditional PID (2.46 s) and fuzzy PID (1.28 s). Finally, the effectiveness of the algorithm is validated through practical application. The results demonstrate that, compared to traditional PID and single-neuron PID algorithms, the WOA-improved single-neuron PID algorithm achieves an average flow stability of 9.9848 with a standard error of 0.0914394. It exhibits superior performance, including faster rise and settling times, and higher stability.

In this paper, an improved high-speed adaptive filter is proposed and implemented using a field-programmable gate array platform. Specifically, a new filter structure combining systolic and convex architectures has been analyzed and compared with conventional filter architectures. The new filter structure efficiently removes power line interference noise from electrocardiogram signals at high convergence speeds. The systolic architecture is used to improve the convergence speed of the filter, and the convex architecture is used in combination to improve the signal-to-noise ratio of the filter. One fast filter was designed using the retimed delay recursive least square algorithm (recursive least square filter design with systolic architecture), and it was combined with one slow filter designed using the least mean square algorithm based on convex combination architecture. The proposed filter architectures are assessed for electrocardiogram noise cancellation, obtained from the MIT-BIH database, and the performance is compared with various filter structures in terms of the signal-to-noise ratio, convergence speed, learning behaviors, and complexity. The results show an improvement in signal-to-noise ratio of 24.2% and an increase in convergence speed of 50% when compared with conventional filter structures. [ABSTRACT FROM AUTHOR]

Background: The coronavirus disease 2019 (COVID-19) is critically affecting not only the physical health but also mental health globally. This study aimed to define the frequency of sleep disorders in COVID-19 positive patients in Aswan University Hospitals, Aswan Governorate, Egypt to clarify the different clinical types of them and to identify factors associated with sleep changes during the COVID-19. Methods: Our study recruited 280 positive COVID-19 patients. Their sleep disorders were diagnosed by using Global Sleep Assessment questionnaire (GSAQ). Their socioeconomic status was determined by using Revised Kuppuswamy Socioeconomic Status Scale (RK SSS). The severity of anxiety symptoms and insomnia were determined by using Hamilton Anxiety Rating Scale (HARS) and Insomnia Severity Index (ISI) respectively. Diagnosis of Restless Leg Syndrome (RLS) was completed according to Restless Leg Syndrome Diagnostic Index (RLS-DI). Results: Sleep disorders were documented in 35.7% of our patients. They were categorized into insomnia (24.6%), RLS (15%) and poor sleep quality (17.4%). Younger age and female sex were the predominate age and sex. Most of them had severe anxiety. Upper class of socioeconomic status was the commonest SES. Most of patients had CORADS I and II respectively. Conclusion: The present study recognized that female gender, younger population, COVID-19 related stressors were the major factors associated with sleep disorder. Further investigation is needed to understand the changes in sleep pattern among the patients of the COVID-19 pandemic. [ABSTRACT FROM AUTHOR]

In this paper, Recursive Least Square (RLS) and Affine Projection (AP) adaptive filters are designed using Xilinx System Generator and implemented on the Spartan6 xc6slx16- 2csg324 FPGA platform. FPGA platform utilizes the non-restoring division algorithm and the COordinate Rotation DIgital Computer (CORDIC) division algorithm to perform the division task of the RLS and AP adaptive filters. The Non-restoring division algorithm demonstrates efficient performance in terms of convergence speed and signal-to-noise ratio. In contrast, the CORDIC division algorithm requires 31 cycles for division initialization, whereas the non-restoring algorithm initializes division in just one cycle. To validate the effectiveness of the proposed filters, a set of ten ECG records from the BIT-MIT database is used to test their ability to remove Power Line Interference (PLI) noise from the ECG signal. The proposed adaptive filters are compared with various adaptive algorithms in terms of Signal-to-Noise Ratio (SNR), convergence speed, residual noise, steady-state Mean Square Error (MSE), and complexity.

Autonomous remote sensing systems establish communication links between nodes. Ensuring coverage and seamless communication in highly dense environments is not a trivial task as localization, separation, and tracking of targets, as well as interference suppression, are challenging. Therefore, smart antenna systems fulfill these requirements by employing beamforming algorithms and are considered a key technology for autonomous remote sensing applications. Among many beamforming algorithms, the recursive least square (RLS) algorithm has proven superior convergence and convergence rate performances. However, the tracking performance of RLS degrades in the case of dynamic targets. The forgetting factor in RLS needs to be updated constantly for fast target tracking. Additionally, multiple beamforming algorithms can be combined to increase tracking performance. An improved hybrid constant modulus RLS beamforming algorithm with an adaptive forgetting factor and a variable regularization factor is proposed. The forgetting factor is updated using the low-complexity yet robust adaptive moment estimation method (ADAM). The sliding-window technique is applied to the proposed algorithm to mitigate the steady-state noise. The proposed algorithm is compared with existing RLS-based algorithms in terms of convergence, convergence rate, and computational complexity. Based on the results, the proposed algorithm has at least 10 times better convergence (accuracy) and a convergence rate two times faster than the compared RLS-based algorithms. [ABSTRACT FROM AUTHOR]

This paper proposes an improved Recursive Least Square (RLS) algorithm to address the limitations of the conventional RLS algorithm, which suffers from poor performance when dealing with non-stationary noise. The proposed algorithm, along with various algorithms, have been designed using Xilinx System Generator (XSG). These algorithms have been tested to denoise ECG signals that have been corrupted with four types of real noise obtained from the MIT-BIH dataset. The improved algorithm utilizes a systolic architecture that enables faster processing and better noise reduction capabilities. The experimental results demonstrate that the proposed algorithm with and without systolic architecture outperforms the conventional RLS algorithm and other state-of-the-art algorithms in terms of signal-to-noise ratio (SNR), mean squared error (MSE), and convergence speed.

IntroductionRestless legs syndrome (RLS) is a debilitating condition characterized by uncomfortable sensations in the legs, typically occurring during periods of rest or sleep. It is more prevalent during pregnancy and is linked to sleep disturbances, diminished quality of life, and pregnancy complications. However, previous studies yielded inconsistent findings among pregnant women in middle-income countries. Consequently, this systematic review and meta-analysis sought to determine the pooled prevalence of restless legs syndrome and its associated factors in these populations.MethodA systematic review and meta-analysis was conducted on published studies from middle-income countries until May 2023. The review strictly adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Relevant search terms were used to search for studies in PubMed, MEDLINE, EMBASE, and Google Scholar. Data extraction was performed using the Joanna Briggs Institute tool for prevalence studies. The meta-analysis was conducted using STATA 17 software, and heterogeneity was assessed using the I2 test, while publication bias was evaluated using Egger's test. Forest plots were also used to present the pooled prevalence and odds ratio (OR) with a 95% confidence interval (CI) using the random-effects model.ResultThis review included 22 studies from nine countries with a total of 17, 580 study participants. The overall pooled prevalence of RLS among pregnant women in middle-income countries was 13.82% (95% CI: 13.31, 14.32), and having low hemoglobin level (AOR: 1.68, 95% CI: 1.29, 2.18), history of RLS (AOR: 7.54, 95% CI: 3.02, 18.79), muscle cramps (AOR: 3.58, 95% CI: 1.21, 10.61), excessive day time sleepiness (AOR: 4.02, 95% CI: 1.34, 12.04), preeclampsia (AOR: 2.06, 95% CI: 1.28, 3.30), and taking prophylactic iron supplementation (AOR: 0.59, 95% CI: 0.50, 0.69) were the identified factors associated with it.ConclusionGenerally, nearly one in every eight pregnant women in middle-income countries develop restless legs syndrome during pregnancy. Having low hemoglobin level, a history of RLS, muscle cramps, excessive daytime sleepiness, preeclampsia, and taking prophylactic iron supplementation were the identified factors associated with it. These findings underscore the importance of addressing the identified factors associated with RLS in order to effectively mitigate its occurrence among pregnant women.

The aim of this study is to examine patients with restless legs syndrome (RLS) in terms of difficulty in emotion regulation and insomnia. A total of 52 patients with RLS and 57 healthy volunteers were enrolled. Difficulties in Emotion Regulation Scale Short Form (DERS-16), Insomnia Severity Index (ISI), Hospital Anxiety and Depression Scale (HADS), and International Restless Legs Syndrome rating scale were applied to participants. The mean age was 34.00 ± 8.27 years in patients and 31.70 ± 9.12 years in control. The scores of DERS-16, ISI, HADS-A, and HADS-D were significantly higher in the patients than the controls (p = 0.000). The DERS-16 total score showed a significant correlation with age (r = 0.404, p = 0.003), ISI (r = 0.281, p = 0.043), IRLS score (r = 0.422, p = 0.002), HADS-A (r = 0.409, p = 0.003), and HADS-D (r = 0.416, p = 0.002). The factors (age, gender, ferritin, ISI, and IRLS scores) that may be associated with the DERS-16 total scores were assessed with stepwise regression analysis. It was seen that the IRLSs variable had the most ability and could predict 45% (β = 0.625, p < 0.001, ∆R2 = 0.450) of difficulty in emotion regulation. In addition, the variable of insomnia could predict difficulty in emotion regulation by 17% (β = 0.097, p = 0.001, ∆R2 = 0.170). Patients with RLS may experience more emotion regulation difficulties than healthy controls. RLS severity and insomnia may be factors affecting emotion regulation difficulties in patients with RLS. According to our knowledge and our literature review, this finding seems to be the first report in the literature. [ABSTRACT FROM AUTHOR]

Background Restless legs syndrome (RLS) is a prevalent sensorimotor disorder that can dramatically impair sleep quality, daytime function, and quality of life. Although many patients benefit from standard pharmacological therapy, some patients suffer from insufficient treatment response or medication intolerance. Novel treatment approaches are therefore necessary. Objective Given the overlap between RLS and pain syndromes in both pathophysiological mechanisms and certain treatment options, we aimed to perform a scoping review of the available evidence on spinal cord stimulation (SCS) for RLS and discuss potential mechanistic implications. Methods We identified a total of 16 cases of patients with RLS who underwent SCS, all from case reports or case series. Discussion The published evidence is insufficient to assess SCS efficacy in patients with RLS, but SCS remains a promising investigational therapy in RLS on the basis of its potential mitigatory effects in the central hyperexcitability of the sensorimotor cortex through neuromodulation of spinal, subcortical, and cortical areas. A call for further research in this field is presented, with suggestions for future directions and trial designs. [ABSTRACT FROM AUTHOR]

The wind turbine (WT) dynamics are affected by wind variations and system parameter changes as well. To deal with the pitch control problem a Self-Tuning Controller (STC) with Proportional-Derivative (PD) structure has been proposed for the benchmark model (BM). This BM also models some sensors, actuators and system faults. The STC design herein is pivoted on a second-order auto-regressive exogenous (ARX) model. At first, three identification methods for the ARX model are presented: Recursive Least Square method (RLS), RLS with exponential forgetting (RLS-EF) and RLS with adaptive directional forgetting (RLS-ADF). In comparison, the performance of RLS-ADF is better than the rest two. The STC PD controller supersedes contemporary adaptive control approaches to fix up the generated power to its rating for above-rated wind. Secondly, on analysis, the proposed STC PD controller is fault-tolerant for nine types of faults. In the third stage, in extensive Monte Carlo Simulation (MCS), the sensitivity test to system parameter variation is carried out including the sensor faults. The result in the presence of a fault, as well as parameter variation, shows minimal deviation from normal conditions indicating the suitability of the STC PD controller to keep the system intact except in case of multiple faults. [ABSTRACT FROM AUTHOR]

Every year the number of IoT devices is growing, which gives a boost to development of such technology as Power Line Communication (PLC). The term PLC refers to the use of a power supply circuit to transmit data. Full-duplex technology can be applied to increase the data transfer rate in a PLC. The difficulty in using a full duplex is the need to suppress the transmitter's own signal (interference signal). Analog cancellation and digital cancellation are used for this purpose. Common algorithms for digital cancellation are adaptive algorithms. In this paper adaptive algorithms such as Particle Swarm Optimization (PSO) and Recursive Least Squares (RLS) are considered and a modification of the classical RLS is proposed. The proposed algorithm uses precalculated weight coefficients together with periodic reinitialization of the filter. This avoids the influence of significant changes in the input signal on the further process of filter adaptation and provides the highest level of echo suppression. The proposed algorithm provides an improvement of parameters such as Error Vector Magnitude (EVM) and Signal-to-Interference Ratio (SIR) in comparison with classical RLS and PSO, according to the results of the study. [ABSTRACT FROM AUTHOR]

In this paper, we study the problem of beam tracking of a multipath channel in millimeter-wave massive MIMO communication system using adaptive filters. We focus on the performance of least-mean-square filter (LMS) and recursive least-squares filter (RLS) algorithms, compared to a reference extended Kalman filter (EKF), in scenarios where the wireless channel is dominated by a single line of sight (LOS) path or a small number of strong paths. The signal direction and channel coefficients are tracked and updated using these filters. Our results recommend that beamforming systems at millimeter-wave bands should consider variable number of paths rather than a single dominant LOS path. Furthermore, we show that the mean squared-error (MSE) of the innovation process gives a better overall view of the tracking performance than the MSE of the state parameters.

Restless Legs Syndrome (RLS) is a common sensorimotor and a sleep disorder that affects 2.5–10% of the European and North American populations. RLS is also often associated with periodic leg movements during sleep (PLMS). Despite ample evidence of genetic contributions, the underlying mechanisms that elicit the sensory and motor symptoms remain unidentified. Clinically, RLS has been correlated with an altered central iron metabolism, particularly in the brain. While several animal models have been developed to determine the outcome of an altered iron homeostasis on brain function, the potential role of an altered iron homeostasis on sleep and sensorimotor circuits has not yet been investigated. Here, we utilize a mouse model to assess the effects of an iron-deficient (ID) but non-anemic state on sleep time and episodes, and sensorimotor reflexes in male and female mice. We found that animals on the ID diet displayed an increased expression of the transferrin receptor in the spinal cord, confirming the results of previous studies that focused only on the impact of ID in the brain. We also demonstrate that the ID diet reduced hematocrit levels compared to controls but not into the anemic range, and that animals on the ID diet exhibited RLS-like symptoms with regard to sleep onset and spinal cord reflex excitability. Interestingly, the effects on the spinal cord were stronger in females than in males, and the ID diet-induced behaviors were rescued by the return of the animals to the control diet. Taken together, these results demonstrate that diet-induced ID changes to CNS function are both inducible and reversible, and that they mimic the sleep and sensorimotor RLS symptoms experienced in the clinic. We therefore propose replacing the commonly used phrase “brain iron deficiency” (BID) hypothesis in the RLS research field with the term “iron deficiency in the central nervous system” (ID-CNS), to include possible effects of altered iron levels on spinal cord function.

Background: In addition to the gastrointestinal symptoms, inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), is associated with extraintestinal manifestations, including neurological disorders, which are gaining increasing attention due to a recently increased focus on the gut–brain axis. Here we aim to evaluate the association between IBD and restless legs syndrome (RLS) as well as Parkinson's disease (PD) in a cohort of primary care patients in Germany. Methods: The study included 17,994 individuals with a diagnosis of IBD (7544 with CD and 10,450 with UC) and 17,994 propensity-score-matched individuals without IBD from the Disease Analyzer database (IQVIA). An initial diagnosis of RLS or PD was assessed as a function of IBD. Associations between CD and UC with RLS and PD were analyzed using Cox regression models. Results: During the 10-year observation period, 3.6% of CD patients vs. 1.9% of matched non-IBD pairs (p < 0.001) and 3.2% of UC patients vs. 2.7% of matched pairs (p < 0.001) were diagnosed with RLS. The results were confirmed by Cox regression analysis, which showed a significant association between UC (HR: 1.26; 95% CI: 1.02–1.55) and CD (HR: 1.60; 95% CI: 1.23–2.09) and subsequent RLS. The incidence of PD in IBD patients was not significantly increased. However, we observed a non-significant trend towards a higher incidence of PD in male patients with CD but not UC (HR: 1.55; 95%CI: 0.98–2.45, p = 0.064). Conclusions: The present analysis suggests a significant association between IBD and the subsequent development of RLS. These findings should stimulate further pathophysiological research and may eventually lead to specific screening measures in patients with IBD. [ABSTRACT FROM AUTHOR]

aims to explore whether the degree of shunt is correlated with the degree of unexplained dizziness and looking for the possible clinical intervention for patients with unexplained dizziness. Methods: This study was a large single-center, prospective, controlled study. From March 2019 to March 2022, patients with unexplained dizziness and explained dizziness and healthy controls were recruited. Contrast-enhanced transcranial Doppler sonography (c-TCD) was performed to detect the existence of right-to-left shunt (RLS) and shunt grading. The dizziness handicap inventory (DHI) was completed to evaluate the dizziness. Unexplained dizziness patients with large amount of PFO were volunteered to receive medication treatment and transcatheter PFO closure and followed up six months. Results: A total of 387 patients (132 unexplained, 123 explained and 132 controls) were enrolled. There was a statistical difference in the RLS grading with three groups (p < 0.001). The Spearman correlation coefficient of RLS grading and DHI scores in unexplained dizziness patients (r=0.122, p=0.163) and explained dizziness patients (r=0.067, p=0.460). In the unexplained group, there were 49 cases with massive grading RLS. Of which 25 patients received percutaneous PFO closure treatment and 24 cases received medication treatment. Followed up six months after treatment, the amount of DHI scores change in patients who received the percutaneous PFO closure was significantly higher than that in the medication treatment group (p < 0.001). Conclusion: RLS may play an important role in unexplained dizziness. For unexplained dizziness patients, PFO closure may contribute to better outcomes. In the future, large-scale randomized controlled studies are still needed. [ABSTRACT FROM AUTHOR]

The global navigation satellite systems (GNSS) receivers suffer from determining an accurate position estimate in the indoor region due to non-line of sight (Non-LOS) conditions. This paper proposes a novel method of position estimation within the indoor region by using distributed GNSS sensors and a range-azimuth sensor setup. All the GNSS sensors are connected to a central node; the inaccurate position estimates evolved from the Kalman filter (KF) framework are transmitted to a central node as primary data. The deviation between the inaccurate position estimate and the GNSS sensor's actual position is the positional deviation (PD) vector, which needs to be estimated. In the same indoor region, a range-azimuth sensor is also deployed. It estimates the GNSS sensor's physical location in its local coordinates, and these estimates are being transmitted to a central node as secondary data. Further, by using the primary and secondary data, we formulated a PD vector compensation followed by a sequential fusion (SF) framework to derive the precise locations of both GNSS sensors and the range-azimuth sensor by recursively estimating the PD vector. Finally, the Cramer–Rao lower bound (CRLB) for the proposed framework is derived. The simulation results are quantified with the root mean square error (RMSE) and CRLB. • GNSS position estimation algorithm using distributed GNSS and range-azimuth sensor. • Position deviation compensation, sequential fusion proposed to estimate GNSS position. • Cramer–Rao lower bound (CRLB) for the proposed framework is derived. • Results are analyzed by varying number of satellite signals and position deviation. • Proposed algorithm find significant applications in indoor localization. [ABSTRACT FROM AUTHOR]

Copyright of Methodical Perspectives / Metodički Vidici is the property of Faculty of Philosophy, University of Novi Sad and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

With the rapid expansion of new energy in China, the large-scale grid connection of new energy is increasing, and the operating safety of the new energy power system is being put to the test. The static security and stability region (SSSR) with hyper-plane expression is an effective instrument for situational awareness and the stability-constrained operation of power systems. This paper proposes a hybrid improved particle swarm optimization (IPSO) and recursive least square (RLS) approach for rapidly approximating the SSSR boundary. Initially, the operating point data in the high-dimensional nodal injection space is examined using the IPSO algorithm to find the key generators, equivalent search space, and crucial points, which have a relatively large impact on static stability. The RLS method is ultimately utilized to fit the SSSR border that best suits the crucial spots. Consequently, the adopted algorithm technique was used to rapidly approximate the SSSR border in power injection spaces. Finally, the suggested algorithm is confirmed by simulating three kinds of generators of the new energy 118 bus system using the DIgSILENT/Power Factory. As a result, this method accurately characterized the stability border of the new energy power system and created the visualization space of the SSSR. Using the SSSR, a rapid state analysis could be undertaken on a variety of parameters, such as security evaluation with diverse energy supply capacities. This study's findings confirmed the accuracy and efficacy of the suggested modeling for the considered system and may thus give technical support for the new energy power system's stability. [ABSTRACT FROM AUTHOR]

Since the last decades, research has pointed out some challenges encountered in Physics Teaching, among which are decontextualized teaching, focusing on preparing students for tests, resulting in learning marked by the memorization of mathematical formulas and concepts. Seeking to minimize these challenges, research has been proposing alternative methodologies with the intention of helping the teacher during the teaching and learning process. Among the proposed methodologies, we highlight the teaching sequences in the format of Potentially Meaningful Teaching Units (PMTU), this didactic methodology is based on the principles of the theory of meaningful learning. Thus, the objective of this research is to identify the contributions and limitations of UEPS investigated in scientific works through a Systematic Literature Review. To achieve this objective, a search for publications was carried out through the Integrated Search Portal of the University of São Paulo (USP), using the keywords "Potentially Meaningful Teaching Units" and its terminology in English and Spanish, as well as the abbreviations "UEPS" and "PMTU". From an initial screening and skimming of the articles, inclusion, exclusion and quality criteria were created, with 12 articles being selected. From the results of the analysis, the articles were grouped into two categories: continuing education and construction of concepts, according to the purpose of applying the UEPS. Through the analysis, it was possible to identify the contributions and limitations of the UEPS presented in the articles, as well as to verify the existence of gaps present in the literature. For future work that intends to adopt a quantitative approach, it is suggested the formative evaluation of the participants throughout the research application. In addition to carrying out investigations seeking the initial or continued training of teachers. As well as research that investigates the construction of concepts in the final years of elementary school and in youth and adult education. [ABSTRACT FROM AUTHOR]

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Recently, with the advancement of technology, unmanned aerial vehicles (UAVs) have had a significant impact on our daily lives. UAVs have gained critical importance due to their potential threat. In this study, the problem of UAV tracks were investigated. The first study deals with a particle filter (PF) and a diffusion map with a Kalman filter (DMK). From the experimental analysis, it is found that both PF and DMK are very suitable for drone tracking because the trajectories of drones are highly uncertain in highly dynamic and noisy environments. To address this problem, we introduce a Kalman filter (KFUEA) for drone tracking based on uncertainty and error. The KFUEA uses regularized least squares (RLS) to minimize measurement errors and provides an appropriate balance between confidence in previous estimates and future measurements. The experiment was conducted to evaluate the performance of KFUEA compared to PF and DMK, taking into account the high uncertainty and noisy UAV tracking environment. The KFUEA algorithm achieved an excellent result in the root mean square error (RMSE) compared to the non-parametric filtering algorithms PF and DMK. [ABSTRACT FROM AUTHOR]

Introduction: We present a literature review on the clinical conundrums surrounding the differential diagnosis of restless legs syndrome (RLS, Willis Ekbom disease), as well as conditions that can mimic RLS. An extensive literature search showed that secondary causes of RLS ranged from commonly recognized causes, such as iron deficiency anemia, to less widely noted causes, such as rheumatoid disorders and hypothyroidism. There is a controversial association with Parkinson's disease, essential tremor and RLS, whereby RLS is proposed as a prodromal feature., Areas Covered: The clinical presentation of restless legs syndrome (RLS), a highly prevalent movement disorder usually during sleep with a circadian variation. The review highlights differences between commonly established secondary causes of RLS, RLS mimics, genetic and drug-induced RLS. A flowchart presents some key features of different and overlapping secondary RLS and mimics and genetic RLS., Expert Opinion: RLS is one of the commonest movement disorders and the International Restless Legs Syndrome Study Group have suggested a five-point criteria for robust diagnosis of RLS. However, even in expert hands diagnosis is accurate in about 85% and misdiagnosis, especially with 'RLS mimics' appears to be high. There are wide variations in the way RLS can present, and this includes different types of secondary RLS as well as drug induced or genetic patterns of RLS. Secondary RLS is highly complex and can be associated with Parkinson's disease as well as prodromal stage of Parkinson and essential tremor. Other known causes of secondary RLS are many and include end stage kidney disease as well as metabolic disorders to painful conditions such as rheumatic disorders and fibromyalgia and polyradiculopathy.

Myoclonus and other jerky movements form a large heterogeneous group of disorders. Clinical neurophysiology studies can have an important contribution to support diagnosis but also to gain insight in the pathophysiology of different kind of jerks. This review focuses on myoclonus, tics, startle disorders, restless legs syndrome, and periodic leg movements during sleep. Myoclonus is defined as brief, shock-like movements, and subtypes can be classified based the anatomical origin. Both the clinical phenotype and the neurophysiological tests support this classification: cortical, cortical-subcortical, subcortical/non-segmental, segmental, peripheral, and functional jerks. The most important techniques used are polymyography and the combination of electromyography-electroencephalography focused on jerk-locked back-averaging, cortico-muscular coherence, and the Bereitschaftspotential. Clinically, the differential diagnosis of myoclonus includes tics, and this diagnosis is mainly based on the history with premonitory urges and the ability to suppress the tic. Electrophysiological tests are mainly applied in a research setting and include the Bereitschaftspotential, local field potentials, transcranial magnetic stimulation, and pre-pulse inhibition. Jerks due to a startling stimulus form the group of startle syndromes. This group includes disorders with an exaggerated startle reflex, such as hyperekplexia and stiff person syndrome, but also neuropsychiatric and stimulus-induced disorders. For these disorders polymyography combined with a startling stimulus can be useful to determine the pattern of muscle activation and thus the diagnosis. Assessment of symptoms in restless legs syndrome and periodic leg movements during sleep can be performed with different validated scoring criteria with the help of electromyography.

In behavioral medicine, sleep disorders, insomnia in particular, may be considered comorbidities and precipitating factors to intellectual or developmental disabilities (IDD). Nevertheless, sleep alterations have often been neglected in favor of daytime features and symptoms, albeit simple behavioral nighttime observations may disclose hypermotor features that characterize restless sleep. The root of most hypermotor restlessness is linked to central iron deficiency. The latter is often exacerbated by vitamin D deficiency (VDD), which interferes with both dopaminergic and serotonergic mechanisms. In this way, an imbalance affecting daytime behavior and mood is created. Several sleep-related motor disorders such as bruxism, periodic and aperiodic leg movements, Restless Legs Syndrome (RLS), and Restless Sleep Disorder (RSD) are commonly seen in Attention Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorders (ASD). However, they are rarely diagnosed and often overlooked in affected children and adolescents. As a result, not only are these disorders not adequately addressed therapeutically, but their symptoms may be worsened by the side-effects of drugs used to contain disruptive daytime behavior, such as antipsychotics and antidepressants. In children with IDDs, obesity, inactivity and metabolic effects of antipsychotics often lead to Sleep Disordered Breathing (SDB), which is currently understood as an inflammatory state leading to "hyperactive" lethargy and further alterations of the hypoxic chain and vitamin D levels. Endorsing simple routine blood tests, including inflammatory markers such as C-reactive protein, ferritin, transferrin, and vitamin D levels, may favorably complement caregiver observations and ambulatory sleep recordings, leading to a sleep disorder diagnosis and consequent therapy. In fact, the treatment of SDB, RLS, and RSD has been copiously demonstrated to favorably impact vigilance, behavior, social competence, and academic skills in healthy and, to a greater extent, in IDD children. Thus, consulting and deliberating the root causes of functional and categorical diagnoses within a clinical framework may engender a more precise diagnosis and further benefit pediatric daytime and nighttime management of hyperactive behaviors. [ABSTRACT FROM AUTHOR]

In this paper, we study the problem of beam tracking of a multipath channel in millimeter-wave massive MIMO communication system using adaptive filters. We focus on the performance of least-mean-square filter (LMS) and recursive least-squares filter (RLS) algorithms, compared to a reference extended Kalman filter (EKF), in scenarios where the wireless channel is dominated by a single line of sight (LOS) path or a small number of strong paths. The signal direction and channel coefficients are tracked and updated using these filters. Our results recommend that beamforming systems at millimeter-wave bands should consider variable number of paths rather than a single dominant LOS path. Furthermore, we show that the mean squared-error (MSE) of the innovation process gives a better overall view of the tracking performance than the MSE of the state parameters. [ABSTRACT FROM AUTHOR]

Interior mounted permanent magnet (IPM) machines have superior features comparing to their counterparts for electric vehicle traction applications. Having relatively higher efficiency, high torque and power densities, low torque ripple and not requirement of regular maintenance are among their superior features. It is widely known that the precise torque control in practical IPM drives highly relies on accurate knowledge of machine parameters viz, inductance values and magnetic flux linkage. These machine parameters vary significantly in real time operation depending on manufacturing tolerance, operating temperature, inductance saturation, load torque and so on. It is known that d- and q- axis inductances and magnetic flux linkage at the full load operation may be approximately 20%, 35% and 20%, respectively, lower than their actual values at no-load operation. It is also commonly known in the literature for traction applications that these variations (considering wide range operation) have much influence on both drive system efficiency and output torque production compared to other system nonlinearities such as stator resistance variation. It has been achieved in this paper that these parameters are estimated online with fairly high accuracies of each, utilizing recursive least squares (RLS) algorithm. The superiority of the proposed drive achieving considerably higher output torque (∼28,7% of peak torque) is validated through extensive realistic simulations with nonlinear machine model of a 4.1 kW prototype IPM machine designed and manufactured for traction applications. Proposed strategy and its superiority among state-of-art drives are discussed in detail.

In behavioral medicine, sleep disorders, insomnia in particular, may be considered comorbidities and precipitating factors to intellectual or developmental disabilities (IDD). Nevertheless, sleep alterations have often been neglected in favor of daytime features and symptoms, albeit simple behavioral nighttime observations may disclose hypermotor features that characterize restless sleep. The root of most hypermotor restlessness is linked to central iron deficiency. The latter is often exacerbated by vitamin D deficiency (VDD), which interferes with both dopaminergic and serotonergic mechanisms. In this way, an imbalance affecting daytime behavior and mood is created. Several sleep-related motor disorders such as bruxism, periodic and aperiodic leg movements, Restless Legs Syndrome (RLS), and Restless Sleep Disorder (RSD) are commonly seen in Attention Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorders (ASD). However, they are rarely diagnosed and often overlooked in affected children and adolescents. As a result, not only are these disorders not adequately addressed therapeutically, but their symptoms may be worsened by the side-effects of drugs used to contain disruptive daytime behavior, such as antipsychotics and antidepressants. In children with IDDs, obesity, inactivity and metabolic effects of antipsychotics often lead to Sleep Disordered Breathing (SDB), which is currently understood as an inflammatory state leading to “hyperactive” lethargy and further alterations of the hypoxic chain and vitamin D levels. Endorsing simple routine blood tests, including inflammatory markers such as C-reactive protein, ferritin, transferrin, and vitamin D levels, may favorably complement caregiver observations and ambulatory sleep recordings, leading to a sleep disorder diagnosis and consequent therapy. In fact, the treatment of SDB, RLS, and RSD has been copiously demonstrated to favorably impact vigilance, behavior, social competence, and academic skills in healthy and, to a greater extent, in IDD children. Thus, consulting and deliberating the root causes of functional and categorical diagnoses within a clinical framework may engender a more precise diagnosis and further benefit pediatric daytime and nighttime management of hyperactive behaviors.

Abstract Objectives Restless Legs Syndrome (RLS) is commonly known to cause morbidity in patients on hemodialysis, making them prone to chronic mental health illnesses such as depression and anxiety, and also adversely impact quality of life. In this study, we examined the association of quality of life, anxiety, and depression with restless leg syndrome in the hemodialysis patients at Karachi Institute of Kidney Diseases. Results About 26.7% of the participants reported RLS among the sample size Presence of RLS was not associated with quality of life, depression, and anxiety. However, p-values

Introduction: Patent foramen ovale (PFO) is potentially associated with abnormal embolisms, and it results in mixing of arteriovenous blood when its right-to-left shunt (RLS) emerges. Present studies have found that PFO is a risk factor that can lead to many diseases. However, few studies have examined the relationship between PFO and dizziness. Methods: This study was a large single-center, prospective, controlled study. From March 2019 to March 2021, we recruited patients with dizziness were divided into two groups: "explained" and "unexplained". All patients were submitted to contrast-enhanced transcranial Doppler ultrasound and screened for PFO. Transesophageal heart ultrasound or right heart catheterization was used to confirm PFO. Additionally, multiple factors were collected and statistical analysis was performed between the two groups. Results: Among the 244 patients included, 123 were in the "explained" group and 121 were in the "unexplained" group. The prevalence of PFO in the "explained" group was 34 (27.4%) compared to 79 (64.7%) in the "unexplained" group. In the "explained" group, 7 were RLS level IV, 6 were level III, 7 were level II, and 14 were level I. For the "unexplained" group, the numbers of patients with levels IV, III, II and I were 27, 26, 12 and 14, respectively. Univariate analysis revealed that PFO (χ2= 34.77, P < 0.001) and age (t = − 3.49, P < 0.001) seemed to be potential risk factor candidates for "unexplained" dizziness. In multiple regression analysis, age (OR = 0.97; 95% CI 0.95– 0.99) and the prevalence of PFO (OR = 4.37; 95% CI 2.50– 7.63) were statistically significant. Massively shunted PFO showed more pronounced risk factors (OR = 8.76; 95% CI 4.04– 19.03). Conclusion: There was a high prevalence of PFO and a greater RLS level in unexplained dizziness. PFO and age were independent risk factors for unexplained dizziness. When treating with unexplained dizziness, especially among young people, we must pay attention to the presence of PFO. [ABSTRACT FROM AUTHOR]

Background: Several studies have reported the efficacy of intravenous (IV) iron for patients with restless legs syndrome (RLS), but little is known about the efficacy or safety of repeated IV iron treatment. The aim of this study was to evaluate the effectiveness of repeated doses of IV ferric carboxymaltose (FCM) in treating RLS symptoms. Methods: Patients who received FCM more than twice for RLS from April 2016 to January 2020 were retrospectively reviewed. Patients who had shown positive response to initial IV FCM re-visited the clinic when their symptoms returned, and received repeated IV FCM (1000 mg). Blood iron panels were measured before initial and repeated IV FCM. We defined 'responders' as patients with a greater than 40% decrease in International Restless Legs Study Group Severity Scale (IRLS) compared with pre-treatment levels. Results: A total of 42 patients, including 26 with primary RLS, 5 with gastrectomy, and 11 with anemia, completed the evaluation. Patients received IV FCM infusion 2–4 times. A total of 21 of 26 (80.8%) primary cases of RLS, 4 of 5 (80.0%) patients with a history of gastrectomy, and 9 of 11 (81.8%) patients with anemia responded to repeated FCM treatment. Serum ferritin levels of patients with primary RLS were higher before the second treatment than the baseline levels. There were no serious adverse events observed in the study. Conclusions: Repeated IV FCM for recurring symptoms is an effective treatment for primary RLS and RLS associated with iron deficiency. Serum ferritin might not be a reliable factor to monitor the sustained effects of IV iron for RLS. [ABSTRACT FROM AUTHOR]

Background: There are only limited reports on the prevalence of restless legs syndrome (RLS) in patients with psychiatric disorders. The present study aimed to evaluate the prevalence and clinical correlates in psychiatric inpatients in Germany and Switzerland. Methods: This is a multicenter cross-sectional study of psychiatric inpatients with an age above 18 years that were diagnosed and evaluated face-to-face using the International RLS Study Group criteria (IRLSSG) and the International RLS severity scale (IRLS). In addition to sociodemographic and biometric data, sleep quality and mood were assessed using the Pittsburgh Sleep Quality Index (PSQI), the Insomnia Severity Index (ISI), the Epworth Sleepiness Scale (ESS), and the Patient Health Questionnaire (PHQ-9). In addition to univariate statistics used to describe and statistically analyze differences in variables of interest between patients with and without RLS, a logistic model was employed to identify predictors for the occurrence of RLS. Results: The prevalence of RLS in a sample of 317 psychiatric inpatients was 16.4%, and 76.9% of these were diagnosed with RLS for the first time. RLS severity was moderate to severe (IRLS ± SD: 20.3 ± 8.4). The prevalences in women (p = 0.0036) and in first-degree relatives with RLS (p = 0.0108) as well as the body mass index (BMI, p = 0.0161) were significantly higher among patients with RLS, while alcohol consumption was significantly lower in the RLS group. With the exception of atypical antipsychotics, treatment with psychotropic drugs was not associated with RLS symptoms. Regarding subjective sleep quality and mood, scores of the PSQI (p = 0.0007), ISI (p = 0.0003), and ESS (p = 0.0005) were higher in patients with RLS, while PHQ-9 scores were not different. A logistic regression analysis identified gender (OR 2.67; 95% CI [1.25; 5.72]), first-degree relatives with RLS (OR 3.29; 95% CI [1.11; 9.73], ESS score (OR 1.09; 95% CI [1.01; 1.17]), and rare alcohol consumption (OR 0.45; 95% CI [0.22; 0.94] as predictors for RLS. Conclusions: Clinically significant RLS had a high prevalence in psychiatric patients. RLS was associated with higher BMI, impaired sleep quality, and lower alcohol consumption. A systematic assessment of restless legs symptoms might contribute to improve the treatment of psychiatric patients. [ABSTRACT FROM AUTHOR]

در سیستم‌های MIMO روش‌های متنوعی برای تخمین کانال وجود دارد که هر کدام نیز دارای عملکردهای متفاوتی هستند. سیستم‌های MIMO مانند یک دستگاه چند معادله و چند مجهول هستند که مجهولات، M سمبل ارسالی از فرستنده و معادلات، N سمبل دریافتی در گیرنده هستند، از این رو از روش‌های مختلف تجزیه ریاضی برای تجزیه ماتریس کانال استفاده می‌شود که تجزیه QRD یکی از این روش‌ها می‌باشد. استفاده از تجزیه ماتریس کانال به همراه الگوریتم‌های وفقی مانند LMS و RLS برای سیستم‌های MIMO سادگی و کاهش پیچیدگی را در پی خواهد داشت. در این مقاله با استفاده از دو الگوریتم LMS و RLS کانال MIMO مدل خواهد شد و به جای تخمین مستقیم ماتریس H کانال که پیچیدگی را به همراه دارد، ابتدا Q و بعد R از ماتریس QR تخمین زده می‌شود که همان تخمین ماتریس کانال می‌باشد. نتایج نشان می‌دهد که مدل کردن کانال با الگوریتم‌های وفقی LMS و RLS و استفاده از تجزیه ریاضی QR کاهش خطا در سیستم‌های MIMO را بدست می‌دهد.

This paper proposes an explicit adaptive controller to damp oscillations and to enhance the single machine infinite bus SMIB stability. Owing to the increasing requests for renewable energy and operating conditions, the identification for power systems has been increased recently. Changes in the power system parameters cause to use an explicit self-tuning control. The controller structure consists of combined on-line identifier and a feedback controller as PID and a radial basis function neural network (RBFNN) which acts as an adaptive power system stabilizer for SMIB. An adaptive linear neural network (ADALINE) depending on the input and output of open loop system is employed as on-line model identification to mimic on-line the SMIB output. The difference between SMIB and the identified model responses is used to adjust the ADALANN model weights on-line depending on a recursive least squares principle RLS and a recursive least square with adaptive directional forgetting RLSMadf. The particles swarm optimization (PSO) beside RLS and RLSMadf assess the weights of (RBFNN) and coefficients of PID controllers depending on the on-line ADALINE model weights. The proposed controller is validated with several operating conditions under various disturbances. The simulation results show the proposed controller whose parameters depend on on-line tuning techniques provides better performance than a conventional PID controller.

BackgroundThere are only limited reports on the prevalence of restless legs syndrome (RLS) in patients with psychiatric disorders. The present study aimed to evaluate the prevalence and clinical correlates in psychiatric inpatients in Germany and Switzerland.MethodsThis is a multicenter cross-sectional study of psychiatric inpatients with an age above 18 years that were diagnosed and evaluated face-to-face using the International RLS Study Group criteria (IRLSSG) and the International RLS severity scale (IRLS). In addition to sociodemographic and biometric data, sleep quality and mood were assessed using the Pittsburgh Sleep Quality Index (PSQI), the Insomnia Severity Index (ISI), the Epworth Sleepiness Scale (ESS), and the Patient Health Questionnaire (PHQ-9). In addition to univariate statistics used to describe and statistically analyze differences in variables of interest between patients with and without RLS, a logistic model was employed to identify predictors for the occurrence of RLS.ResultsThe prevalence of RLS in a sample of 317 psychiatric inpatients was 16.4%, and 76.9% of these were diagnosed with RLS for the first time. RLS severity was moderate to severe (IRLS ± SD: 20.3 ± 8.4). The prevalences in women (p = 0.0036) and in first-degree relatives with RLS (p = 0.0108) as well as the body mass index (BMI, p = 0.0161) were significantly higher among patients with RLS, while alcohol consumption was significantly lower in the RLS group. With the exception of atypical antipsychotics, treatment with psychotropic drugs was not associated with RLS symptoms. Regarding subjective sleep quality and mood, scores of the PSQI (p = 0.0007), ISI (p = 0.0003), and ESS (p = 0.0005) were higher in patients with RLS, while PHQ-9 scores were not different. A logistic regression analysis identified gender (OR 2.67; 95% CI [1.25; 5.72]), first-degree relatives with RLS (OR 3.29; 95% CI [1.11; 9.73], ESS score (OR 1.09; 95% CI [1.01; 1.17]), and rare alcohol consumption (OR 0.45; 95% CI [0.22; 0.94] as predictors for RLS.ConclusionsClinically significant RLS had a high prevalence in psychiatric patients. RLS was associated with higher BMI, impaired sleep quality, and lower alcohol consumption. A systematic assessment of restless legs symptoms might contribute to improve the treatment of psychiatric patients.

Study objectives: Studies on brain iron content in restless legs syndrome (RLS) using magnetic resonance imaging (MRI) are heterogeneous. In this study, we sought to leverage the availability of a large dataset including a range of iron-sensitive MRI techniques to reassess the association between brain iron content and RLS with added statistical power and to compare these results to previous studies. Methods: The relaxation rates R2, R2′, and R2* and quantitative susceptibility are MRI parameters strongly correlated to iron content. In general, these parameters are sensitive to magnetic field variations caused by iron particles. These parameters were quantified within iron-rich brain regions using a fully automatized approach in a cohort of 72 RLS patients and individually age and gender-matched healthy controls identified from an existing dataset acquired at the Sleep Laboratory of the Department of Neurology, Medical University of Innsbruck. 3 T-MRI measures were corrected for age and volume of the segmented brain nuclei and results were compared with previous findings in a meta-analysis. Results: In our cohort, RLS patients had increased R2* signal in the caudate and increased quantitative susceptibility signal in the putamen and the red nucleus compared to controls, suggesting increased iron content in these areas. The meta-analysis revealed no significant pooled effect across all brain regions. Furthermore, potential publication bias was identified for the substantia nigra. Conclusions: Normal and increased iron content of subcortical brain areas detected in this study is not in line with the hypothesis of reduced brain iron storage, but favors CSF investigations and post mortem studies indicating alteration of brain iron mobilization and homeostasis in RLS.

Independent joint control by disturbance observer schemes requires the information of an inertial mass and an angular acceleration of each joint of a robot manipulator in a real-time fashion. When both the inertial mass and acceleration information is available, we can easily estimate the joint disturbances. However, it is difficult and costly to mount a torque sensor on each joint and accelerometer. In addition, when the information obtained through the optical encoder is estimated by the finite difference method, the estimated angular velocity and acceleration may be noisy. In this paper, a costly effective data-driven approach for the identification of a link parameter of a robot is presented. Based on the input and output data, a joint model is estimated by the recursive least square (RLS) algorithm. Using the identified models, a state observer in the discrete domain is designed to estimate the joint acceleration signal of a robot manipulator. A combined structure of RLS and state observer is implemented in digital control hardware to estimate the inertial mass as well as the angular acceleration of each joint in a real-time fashion without adding any cost. The performance of estimating the angular acceleration and inertial mass of each joint of a robot manipulator are empirically compared with the finite difference method under the same hardware condition. [ABSTRACT FROM AUTHOR]